Method for improving moisture absorption resistance of traditional Chinese medicine dry extract

Abstract

The invention relates to the technical field of anti-hygroscopicity of traditional Chinese medicine extract powder, and particularly discloses a traditional Chinese medicine dry extract anti-hygroscopicity improving method which comprises the following steps: measuring the solubility parameter delta cream of a traditional Chinese medicine dry extract; a matched solvent system is screened and comprises a good solvent I and a weak polar solvent II, the solubility parameter delta I of the good solvent I meets the following condition that delta I-delta paste is smaller than or equal to 3.5, and the solubility parameter delta II of the weak polar solvent II meets the following condition that delta I-delta II is larger than 1 and smaller than or equal to 7; adding the traditional Chinese medicine dry extract into the good solvent I for dissolution reaction, and then adding the weak polar solvent II for reaction to obtain a self-assembled gel supramolecular extract system; and drying the gel supramolecular extract system to obtain the self-assembled gel supramolecular dry extract. According to the method for improving the moisture absorption resistance of the traditional Chinese medicine dry extract, the moisture absorption resistance of the dry extract can be remarkably improved. In the drying process, only a solvent needs to be added for treatment, the solvent is evaporated in the drying process, the composition of the extract is not affected, additional equipment is not added, the method is simple, and the cost is low.

Description

Technical Field

[0001] The invention relates to the technical field of anti-hygroscopicity of traditional Chinese medicine extract powder, and in particular to a method for improving the anti-hygroscopicity of traditional Chinese medicine dry extract. Background Art

[0002] Chinese herbal medicine extract powder is a product obtained by extracting, separating, concentrating, and drying Chinese herbal medicines. It is an intermediate material for preparing solid preparations such as Chinese herbal medicine granules, tablets, capsules, and pills. Chinese herbal medicine extract powder has the characteristics of strong hygroscopicity. First, because Chinese herbal medicine extract powder is a collection of multiple chemical components and contains a large part of water-soluble components, the critical relative humidity of Chinese herbal medicine extract powder is low, which makes Chinese herbal medicine extract powder able to absorb moisture even when the air humidity is low. On the other hand, some Chinese herbal medicine extract powders contain hygroscopic components such as saponins, tannins, polysaccharides, proteins, and starch. These components contain a large number of polar groups such as hydroxyl groups and amino groups that are easy to combine with hydroxyl groups in water molecules. These components have a strong ability to bind water, which further enhances the hygroscopicity of the extract powder. The strong hygroscopicity of Chinese herbal medicine extract powder will affect the production process, transportation, storage, and product quality of Chinese herbal medicine solid preparations. For example, it will easily cause agglomeration, stickiness, softening of particles, and mildew during the preparation process of extract powder, affecting the stability of Chinese herbal medicine preparations. Therefore, in the production design process of traditional Chinese medicine preparations, not only the active ingredients of the medicine should be considered, but also the hygroscopicity resistance of the drug powder should be considered to ensure the stability of the drug quality.

[0003] At present, the main methods for improving the anti-hygroscopicity of Chinese medicine extracts include: alcohol precipitation method, excipient method, granulation technology and coating technology. The alcohol precipitation method is to add ethanol to the water extract to precipitate the high molecular impurities, thereby refining the drug and reducing the hygroscopic components to achieve a moisture-proof effect. This method is suitable for the extraction of a variety of Chinese medicinal materials, especially in the extraction of medicinal materials containing more water-soluble impurities such as mucus, protein, and sugar. However, the alcohol precipitation method has the following disadvantages: ① It is necessary to control the concentration and temperature of ethanol, and certain technical requirements are required during the operation. ② For some drug components, there may be a certain loss. Excipient method: Select excipients such as excipients, disintegrants, binders and additives, such as sucrose, dextrin, corn protein, magnesium stearate and sodium carboxymethyl cellulose, etc. to improve the hygroscopicity of Chinese medicine dry extracts. Disadvantages of the excipient method: ① The compatibility of the added excipients with the drug itself affects the efficacy. ② Change the dissolution rate of the active ingredient and increase the dosage. Granulation technology: rapid stirring, extrusion granulation, swing granulation, spray granulation and other methods are used to change the residual solvent content, capsule wall density, microcapsule particle size, particle morphology characteristics, etc. in the particles, thereby improving the hygroscopicity of the extract particles. Disadvantages of granulation technology: the physical stacking state of the particles is changed macroscopically, and the improvement of hygroscopicity is limited. Coating technology: capsules and film coatings are used to isolate the drug from contact with moisture. The current packaging materials mainly include plastic composite films, aluminized composite films, aluminum foil composite films, etc. Disadvantages of coating technology: additional packaging costs are increased, which puts pressure on environmental resources. The present invention develops a method for improving the hygroscopicity resistance of traditional Chinese medicine dry extracts. It adopts solvated self-assembly technology without changing the composition of the traditional Chinese medicine extract itself. Through the directional assembly of hydrophobic groups, a hydrophobic film is formed on the surface of the extract particles, thereby improving the hygroscopicity resistance of the extract particles. Summary of the invention

[0004] In view of the above shortcomings, the present invention provides a method for improving the hygroscopicity of a Chinese medicine dry extract, which can significantly improve the hygroscopicity of the dry extract through solvation treatment. The treatment method is simple and does not change the composition of the Chinese medicine extract itself. The specific technical solution is:

[0005] A method for improving the anti-hygroscopicity of a traditional Chinese medicine dry extract comprises the following steps:

[0006] (1) Determination of the solubility parameter δ of Chinese medicine dry extract 膏 ;

[0007] (2) Redissolution and solvation self-assembly of the extract: Screening a matching solvent system, wherein the solvent system includes a good solvent I and a weakly polar solvent II, and the solubility parameter δ of the good solvent I is I The following conditions are met: |δ I -δ 膏 |≤3.5, the solubility parameter δ of the weakly polar solvent II II Satisfy the following conditions: 1<δ I-δ II ≤7; adding the Chinese medicine dry extract to the good solvent I for dissolution reaction, and then adding the weak polar solvent II for reaction to obtain a self-assembled gel supramolecular extract system; through the above solvent treatment, the solute molecules-solute molecules and solute molecules-solvent molecules in the Chinese medicine extract meet appropriate equilibrium conditions, so that the polar solvent is adsorbed and dispersed in the extract supramolecular body, forming a gel supramolecular body with an ideal spatial configuration of non-polar groups on the periphery and polar groups on the inner layer;

[0008] (3) Drying: Drying the gel supramolecular extract system to obtain a self-assembled gel supramolecular dry extract.

[0009] The working principle of the technical scheme of the present invention is as follows: Chinese medicine extract is a supramolecular aggregate formed by the interaction of Chinese medicine guest molecules under the action of solvent according to the imprinting template characteristics of hydrophilic and lipophilic groups. The exposed polar groups in the extract particles obtained by direct drying of Chinese medicine water extracts are very easy to form hydrogen bonds with water in the air, resulting in poor anti-hygroscopicity. Through the action of solvent, the chain links in the supramolecular body of Chinese medicine extract are flipped and the hydrophilic and lipophilic groups are assembled, changing its supramolecular spatial configuration, thereby regulating the hygroscopicity of Chinese medicine extract particles; the present invention screens a matching solvent system, performs solvation treatment on the Chinese medicine extract, realizes the self-assembly process control of the hydrophobic micelles and supramolecular body of the Chinese medicine extract, dissolves the Chinese medicine extract in a good solvent with a certain solubility parameter, and then adds a weak polar solvent with a similar solubility parameter to form a gel supramolecular body with an ideal spatial configuration of non-polar groups on the periphery and polar groups on the inner layer.

[0010] Preferably, in the above-mentioned method for improving the hygroscopicity resistance of traditional Chinese medicine dry extract, in the step (1), the inverse gas chromatography (IGC method) is used for testing, and the testing method comprises: coating the extract on an inert carrier, and then filling it into a chromatographic column, using an inert gas as a carrier gas, and a solvent as a probe, and measuring the retention time of the probe molecule in the chromatographic column at different column temperatures, and calculating the solubility parameter of the extract according to the relationship between the free energy parameter and the solubility parameter of the polymer.

[0011] Preferably, in the above-mentioned method for improving the hygroscopicity resistance of traditional Chinese medicine dry extract, in step (1), the solvent is n-hexane, cyclohexane, toluene, benzene, chloroform, or isopropanol.

[0012] Preferably, in the above-mentioned method for improving the anti-hygroscopicity of traditional Chinese medicine dry extract, the solubility parameter δ of the weak polar solvent II is II Satisfy the following conditions: 2≤δ I -δ II ≤3.5.

[0013] Preferably, in the above-mentioned method for improving the anti-hygroscopicity of traditional Chinese medicine dry extract, the good solvent I and the weak polar solvent II are a single solvent or a multi-solvent system, and the solubility parameter of the multi-solvent system is: in is the volume fraction of each solvent component, δ1, δ2, δ n is the solubility parameter of each solvent component. The solubility parameter of a single solvent can be obtained by referring to the solubility parameter table of commonly used solvents.

[0014] Preferably, in the above-mentioned method for improving the hygroscopicity resistance of traditional Chinese medicine dry extract, the mass ratio of the traditional Chinese medicine dry extract, the good solvent I and the weak polar solvent II is 1:1-2:1-2.

[0015] Preferably, in the above-mentioned method for improving the anti-hygroscopicity of traditional Chinese medicine dry extract, in the step (2), the traditional Chinese medicine dry extract is added to the good solvent I for heating and ultrasonic dissolution reaction for 0.5 to 1.5 hours, the heating temperature is 60 to 80°C, and then the weak polar solvent II is added to react at 60 to 80°C for 0.5 to 1.5 hours.

[0016] Preferably, in the above-mentioned method for improving the hygroscopicity resistance of traditional Chinese medicine dry extract, in the step (3), the drying method is: distillation under reduced pressure until the extract system becomes viscous, then evaporating in a water bath to a paste, and then vacuum drying; or directly using spray drying.

[0017] Preferably, in the above-mentioned method for improving the hygroscopicity resistance of traditional Chinese medicine dry extract, the extract system is heated in a water bath at 80°C, the pressure in the decompression device is controlled to be 0.1MPa, and the extract liquid is evaporated under reduced pressure until it becomes viscous, transferred to a crucible and evaporated in a water bath at 90°C to a paste, and then dried in a vacuum drying oven at 100°C; the evaporation and escape rate of the solvent molecules are controlled by reduced pressure distillation, thereby maintaining the structure of the hydrophobic micelles or supramolecular bodies.

[0018] Preferably, in the above-mentioned method for improving the anti-hygroscopicity of traditional Chinese medicine dry extract, the spray drying is: atomization is performed by a high-speed atomizer, the rotation speed of the centrifugal atomizer is 3000 rpm, and the drying temperature in the spray drying tower is 105°C; due to the surface tension of the atomized small particles, hydrophobic micelles or supramolecular micro-droplets with smaller diameters are formed, which can better promote the in-situ evaporation and escape of solvent molecules.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] 1. The method for improving the hygroscopic resistance of a traditional Chinese medicine dry extract of the present invention realizes the self-assembly process control of hydrophobic micelles and supramolecular bodies of the traditional Chinese medicine extract through solvation treatment, thereby forming a gel supramolecular body with an ideal spatial configuration of non-polar groups on the periphery and polar groups on the inner layer, which can significantly improve the hygroscopic resistance of the dry extract.

[0021] 2. The method for improving the hygroscopicity resistance of the traditional Chinese medicine dry extract of the present invention only requires the addition of a solvent for treatment. The solvent is evaporated during the drying process and does not affect the composition of the extract itself. In the entire method, only the solvation treatment and the drying process are performed without adding additional equipment. The method is simple and the cost is low. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are some embodiments of the present invention, and for ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0023] Figure 1 The SEM images of the extracts of the embodiments and comparative examples of the present invention are as follows: (a) Control Example; (b) Embodiment 1; (c) Embodiment 2; (d) Comparative Example 1.

[0024] Figure 2 The hygroscopic performance diagrams of the extracts of the embodiments of the present invention and the comparative examples are as follows: (a) relative humidity-hygroscopicity curve diagram; (b) hygroscopicity-time curve diagram;

[0025] Figure 3 Graph showing critical relative humidity values ​​of embodiments and comparative examples of the present invention: (a) Control Example; (b) Embodiment 1; (c) Embodiment 2; (d) Comparative Example 1. DETAILED DESCRIPTION

[0026] The specific embodiments of the present invention are described in detail below, but it should be understood that the protection scope of the present invention is not limited by the specific embodiments. Unless otherwise defined, all professional terms used hereinafter have the same meaning as those generally understood by those skilled in the art. The professional terms used herein are only for the purpose of describing specific embodiments and are not intended to limit the protection scope of the present invention. Unless otherwise specifically stated, various raw materials, reagents, instruments and equipment used in the present invention, etc. can be purchased from the market or can be prepared by existing methods.

[0027] The extracts in the following embodiments and comparative examples take Yigan Ning extract as an example. Yigan Ning extract is made of thirteen Chinese medicinal materials such as Astragalus, Artemisia Capillaris, and Toosendan Fructus, and has the effects of invigorating the spleen and removing dampness, nourishing the kidney and liver, promoting blood circulation and removing blood stasis, clearing away heat and detoxifying. It is used for patients with internal dampness and heat, liver depression and spleen deficiency, and qi deficiency and blood stasis. It is a clinically effective prescription for treating chronic migratory hepatitis. Yigan Ning extract granules are prone to severe moisture absorption in an open environment during production, storage and transportation, causing them to become syrupy and viscous. It is a typical solid preparation of Chinese medicine with severe hygroscopicity.

[0028] prescription:

[0029] Astragalus 606g, Artemisia capillaris 606g, White Peony 408g, Toosendan Fructus 408g, Salvia miltiorrhiza 490g, Codonopsis pilosula 490g, Atractylodes macrocephala 408g, Processed Polygonum multiflorum 490g, Poria 408g, Hedyotis diffusa 408g, Taraxacum mongolicum 408g, Paeonia suffruticosa 408g, and Centella asiatica 408g.

[0030] The preparation of Yiganning extract includes:

[0031] Extraction of extract solution: Soak the Chinese herbal medicine slices in water for 30 minutes, add 10 times water and boil and reflux for 2 hours, collect the extract once, add 8 times water and boil and reflux for 2 hours to collect the water extract, and combine the two water extracts;

[0032] Initial drying of the extract: Concentrate and dry the Chinese medicine extract by reduced pressure evaporation; heat the Chinese medicine aqueous extract in a water bath at 80°C, control the pressure in the reduced pressure device to 0.1MPa, evaporate under reduced pressure until the extract liquid becomes viscous, transfer to a crucible and evaporate in a water bath at 90°C to a paste, and then dry in a vacuum drying oven at 100°C for 48 hours.

[0033] Example 1

[0034] The method for improving the anti-hygroscopicity of the traditional Chinese medicine dry extract of this embodiment comprises the following steps:

[0035] (1) Determination of the solubility parameter δ of Chinese medicine dry extract by IGC method 膏 :

[0036] After dissolving the Chinese medicine dry extract with acetone, it was evenly coated on a 101 white support (60-80 mesh), and the acetone was slowly evaporated. After static and dynamic aging, it was filled in a stainless steel filling column to obtain a chromatographic column with a certain coating concentration and coating quality. SP-6890 gas chromatograph (Shandong Lunan Ruihong Chemical Instrument Co., Ltd.) was used. Hexane, cyclohexane, toluene, benzene, chloroform, and isopropanol were used as probe molecules. Taking the toluene probe molecule as an example, the specific method is: after installing the chromatographic column, check the airtightness of the gas path, and determine the chromatographic conditions according to parameters such as the boiling point of toluene (110°C): TCD detector temperature 150°C, vaporization chamber temperature 120°C, column chamber temperature 37°C, 47°C, 56°C, 66°C, 75°C, 84°C, and inject toluene sample. The headspace injection method was used to determine the retention time of the probe molecule in the chromatographic column at different column temperatures. Then, according to the relationship between free energy parameter and polymer solubility parameter, the solubility parameter of the extract was calculated (refer to Liu Wenlong, He Fuyuan, Zhang Xili. Methodological study on determination of solubility parameter of amygdalin by IGC method [J]. Chinese Patent Medicine, 2008, 30(3): 415-417); the solubility parameter of Yiganning extract was determined to be (18.1cal 1 / 2 cm -3 / 2 );

[0037] (2) Redissolution and solvation self-assembly of the extract: Screening a matching solvent system, the solvent system consists of a good solvent I and a weak polar solvent II, and the good solvent I and the weak polar solvent II are selected according to the following conditions: |δ I -δ 膏 |≤3.5,1<δ I -δ II ≤7; According to step (1), the solubility parameter of Yiganning extract is 18.1cal 1 / 2 .cm -3 / 2 , ethanol aqueous solution was selected as good solvent I, the volume ratio of ethanol to water was 0.7:0.3, and the solubility parameter of ethanol aqueous solution was 16.05 cal 1 / 2 .cm -3 / 2 (The solubility parameter of water is 23.4 cal 1 / 2 .cm -3 / 2 , the solubility parameter of ethanol is 12.9 cal 1 / 2 .cm -3 / 2 , according to the solubility parameter calculation formula of the multi-solvent system δ 混 =φ1δ1+φ2δ2+…+φ n δ n ) to obtain the solubility parameters of ethanol aqueous solution, and select ethanol (solubility parameter is 12.9cal 1 / 2 .cm -3 / 2 ) is a weak polar solvent II; adding a Chinese medicine dry extract to a good solvent I, the weight ratio of the Chinese medicine dry extract to the good solvent I is 1:1, ultrasonically reacting at 80°C for 1h, and then adding a weak polar solvent II to react for 1h, the weight ratio of the Chinese medicine dry extract to the weak polar solvent II is 1:1, so that the solute molecules-solute molecules and the solute molecules-solvent molecules in the Chinese medicine extract meet appropriate equilibrium conditions, so that the polar solvent is adsorbed and dispersed in the extract supramolecular body, forming a gel supramolecular body with an ideal spatial configuration of non-polar groups on the periphery and polar groups on the inner layer, and obtaining a self-assembled gel supramolecular body extract system;

[0038] (3) Drying: The extract system obtained in step (2) is heated in a water bath at 80° C., the pressure in the decompression device is controlled to be 0.1 MPa, and the extract liquid is evaporated under reduced pressure until it becomes viscous, and then transferred to a crucible and evaporated in a water bath at 90° C. until it becomes a paste, and then dried in a vacuum drying oven at 100° C. for 48 hours to obtain a self-assembled gel supramolecular dry extract.

[0039] Example 2

[0040] The difference between this embodiment and embodiment 1 is that the weak polar solvent II is a mixed solvent of ethanol and petroleum ether, the volume ratio is 1:1, and the solubility parameter is 10.05 cal 1 / 2 cm -3 / 2 .

[0041] Comparative Example 1

[0042] The difference between this embodiment and embodiment 1 is that the weak polar solvent II is petroleum ether with a solubility parameter of 7.2 cal 1 / 2 cm -3 / 2 .

[0043] Comparison Example

[0044] The extract was not solvated.

[0045] The dry extracts prepared in Example 1, Example 2 and Comparative Example 1 and the extracts in the control group were characterized for their hygroscopic properties. In a humidistat with a relative humidity of 75%, the weight of the extract particles was weighed at different times to calculate the hygroscopicity. A hygroscopicity time curve was drawn with the measurement time as the horizontal axis and the sample hygroscopicity as the vertical axis. In a humidistat with relative humidity of 20%, 28.5%, 40.5%, 48.5%, 57.7%, 64%, 70%, 75.8%, 80%, 85%, and 92.2%, after the extract reached saturation, it was weighed and the hygroscopicity was calculated. A relative humidity-hygroscopicity curve was drawn with relative humidity as the horizontal axis and the sample hygroscopicity as the vertical axis. Two straight line equations were calculated from the first two points and the last two points of the curve corresponding to the sample hygroscopicity at different humidities at the 168th hour, and the horizontal axis corresponding to the intersection of the two straight lines was the critical relative humidity CRH value of the sample.

[0046] Figure 1 The SEM images of the extracts of the embodiments of the present invention and the comparative examples show that the extracts without solvent treatment have more pores with larger diameters, which is related to the evaporation of water molecules in the extract. The water molecules have a greater force on the polar groups in the extract supramolecular body, and the water molecules are evenly dispersed in the extract. As the water molecules evaporate and escape, channels are left in the extract to form pores. The polar groups are exposed in the pores, easily contacting the air and reacting with the water molecules in the air to cause moisture absorption. After solvent treatment, the pores in the extract are significantly smaller. This may be because the force between the solvent molecule and the solute molecule becomes smaller, and the force between the solute molecule and the solute molecule is greater than the force between the solvent molecule and the solute molecule, forming hydrogen bonds inside the supramolecular body, and some polar solvent molecules are adsorbed in the supramolecular body. Therefore, small pores are distributed in the extract. This structure is conducive to improving the anti-hygroscopic properties of the extract particles.

[0047] Figure 2 (a) is the relative humidity-hygroscopicity curve of the extract, Figure 2 (b) Moisture absorption-time curve of the extract, Figure 3is the critical relative humidity value of the extract. It can be seen from the figure that, compared with the untreated extract, the moisture absorption rate of the extract treated with the solvent at different humidity levels is significantly reduced, and the moisture absorption rate is also significantly reduced, and the critical relative humidity value of the extract becomes larger, which means that it starts to absorb moisture significantly under higher humidity conditions. In summary, it can be seen that the method for improving the hygroscopic resistance of traditional Chinese medicine dry extracts of the present invention can significantly improve the hygroscopic resistance of the extract.

[0048] The foregoing description of specific exemplary embodiments of the present invention is for the purpose of illustration and demonstration. These descriptions are not intended to limit the present invention to the precise form disclosed, and it is clear that many changes and variations can be made based on the above teachings. The purpose of selecting and describing the exemplary embodiments is to explain the specific principles of the present invention and its practical application, so that those skilled in the art can realize and utilize various different exemplary embodiments of the present invention and various different selections and changes. The scope of the present invention is intended to be limited by the claims and their equivalents.

Claims

1. A method for improving the hygroscopicity resistance of a traditional Chinese medicine dry extract, characterized in that: The following steps are involved: (1) Determination of the solubility parameter δ of Chinese medicine dry extract 膏 ; (2) Redissolution and solvation self-assembly of the extract: Screening a matching solvent system, wherein the solvent system includes a good solvent I and a weakly polar solvent II, and the solubility parameter δ of the good solvent I is I The following conditions are met: |δ I -δ 膏 |≤3.5, the solubility parameter δ of the weakly polar solvent II II The following conditions are met: 1<δ I -δ II ≤7; The Chinese medicine dry extract is added into the good solvent I for dissolution reaction, and then the weak polar solvent II is added for reaction to obtain a self-assembled gel supramolecular extract system; (3) Drying: Drying the gel supramolecular extract system to obtain a self-assembled gel supramolecular dry extract.

2. The method for improving the hygroscopicity resistance of a Chinese medicine dry extract according to claim 1, characterized in that: In the step (1), reverse gas chromatography is used for testing, and the testing steps include: coating the extract on an inert support, then filling it into a chromatographic column, using an inert gas as a carrier gas, and a solvent as a probe, measuring the retention time of the probe molecule in the chromatographic column at different column temperatures, and calculating the solubility parameter of the extract based on the relationship between the free energy parameter and the solubility parameter of the polymer.

3. The method for improving the hygroscopicity resistance of a Chinese medicine dry extract according to claim 2, characterized in that: In the step (1), the solvent is n-hexane, cyclohexane, toluene, benzene, chloroform, or isopropanol.

4. The method for improving the hygroscopicity resistance of a Chinese medicine dry extract according to claim 1, characterized in that: The solubility parameter δ of the weakly polar solvent II II The following conditions are met: 2≤δ I -δ II ≤3.

5.

5. The method for improving the hygroscopicity resistance of a Chinese medicine dry extract according to claim 1, characterized in that: The good solvent I and the weakly polar solvent II are a single solvent or a multi-solvent system, and the solubility parameter of the multi-solvent system is: in is the volume fraction of each solvent component, δ1, δ2, δ n is the solubility parameter of each solvent component.

6. The method for improving the hygroscopicity resistance of a traditional Chinese medicine dry extract according to claim 1, characterized in that: In the step (2), the Chinese medicine dry extract is added to the good solvent I and heated to carry out ultrasonic dissolution reaction for 1 to 1.5 hours, the heating temperature is 60 to 80° C., and then the weak polar solvent II is added to react at 60 to 80° C. for 1 to 1.5 hours.

7. The method for improving the anti-hygroscopicity of a Chinese medicine dry extract according to claim 1, characterized in that: The mass ratio of the traditional Chinese medicine dry extract, the good solvent I and the weak polar solvent II is 1:1-2:1-2.

8. The method for improving the hygroscopicity resistance of a Chinese medicine dry extract according to claim 1, characterized in that: In the step (3), the drying method is: vacuum distillation until the extract system becomes viscous, then evaporation in a water bath to a paste state, and then vacuum drying; or spray drying.

9. The method for improving the hygroscopicity resistance of a Chinese medicine dry extract according to claim 8, characterized in that: The extract system is heated in a water bath at 80°C, the pressure in the decompression device is controlled to be 0.1MPa, and the extract liquid is evaporated under reduced pressure until it becomes viscous, and then transferred to a crucible and evaporated in a water bath at 90°C to a paste state, and then dried in a vacuum drying oven at 100°C; the spray drying: atomization is performed by a high-speed atomizer, the rotation speed of the centrifugal atomizer is 3000 rpm, and the drying temperature in the spray drying tower is 105°C.

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