Traditional Chinese medicine composition for invigorating qi and blood as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to a traditional Chinese medicine composition and a preparation method and application thereof. The traditional Chinese medicine extract is prepared from the following traditional Chinese medicinal materials in parts by weight: 20-40 parts of radix rehmanniae praeparata, 20-40 parts of poria cocos, 30-50 parts of radix scutellariae, 15-35 parts of rhizoma atractylodis macrocephalae, 30-50 parts of radix angelicae pubescentis, 15-35 parts of fried fructus gardeniae, 15-35 parts of wine-prepared fructus corni, 15-35 parts of rhizoma alismatis, 15-35 parts of Chinese dates, 15-35 parts of radix saposhnikoviae, 30-50 parts of semen boitae and 15-35 parts of bunge cherry seeds. The traditional Chinese medicine composition is prepared from, by weight, 30-50 parts of Chinese yam, 15-35 parts of safflower carthamus, 15-35 parts of codonopsis pilosula, 15-35 parts of bupleurum chinense, 10-30 parts of moutan bark, 20-40 parts of angelica sinensis, 5-25 parts of salted eucommia ulmoides, 5-25 parts of radix cyathulae, 10-30 parts of vine of multiflower knotweed, 20-40 parts of fructus cannabis, 10-30 parts of gypsum and 20-40 parts of deer-horn glue. The traditional Chinese medicine extract can be used for invigorating qi and blood, promoting blood circulation to remove blood stasis, regulating and nourishing liver and kidney and / or strengthening tendons and bones.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition and a preparation method thereof and an application thereof in replenishing qi and blood. Background Art

[0002] There are many common complications after major orthopedic surgery. Postoperative complications refer to the occurrence of another or several diseases related to the treatment of a disease during the treatment of a certain disease. Common postoperative complications include infection. Because surgery is a traumatic treatment, the patient's resistance will decrease, and postoperative infection and postoperative fever will occur. Postoperative fever is the most common symptom. For example, incision infection, which occurs a few days after surgery, is related to the patient's physique and the nature of the lesion; poor incision healing, postoperative incision infection or fat liquefaction, cannot heal on time; deep vein thrombosis of the lower limbs, intraoperative trauma, slow venous return of patients who are bedridden after surgery, and surgically damaged tissues release a large amount of coagulation substances into the blood, which can all cause deep vein thrombosis and affect postoperative recovery. These diseases seriously affect people's work and life. Existing methods for conditioning the above-mentioned diseases include treatment by taking chemical drugs, regulating physical condition through a reasonable diet, balanced nutrition and increasing outdoor physical exercise activities, adjusting life patterns, ensuring adequate sleep, increasing leisure time, travel time and adjusting psychological state.

[0003] However, the use of chemical drugs for treatment will produce various toxic side effects, is not safe, and may also have a secondary impact on human health.

[0004] Treatment with traditional Chinese medicine is safe and reliable, has no toxic side effects, avoids problems caused by Western medicine hormones, is low-cost, and is convenient for long-term use. The bottled paste is easy to carry and take. It can replenish qi and blood, promote blood circulation and remove blood stasis, regulate the liver and kidneys, strengthen the tendons and bones, and at the same time can greatly replenish vitality, enhance the body's resistance, and also has the effect of preventing diseases. Summary of the invention

[0005] One or more embodiments of the present application provide a Chinese medicine composition, which is prepared from the following Chinese medicinal materials in parts by weight:

[0006] 20-40 weight parts of Rehmannia glutinosa, 20-40 weight parts of Poria cocos, 30-50 weight parts of Scutellaria baicalensis, 10-20 weight parts of Atractylodes macrocephala 5-35 weight parts, 30-50 weight parts of Angelica dahurica, 15-35 weight parts of stir-fried Gardenia jasminoides, 15-35 weight parts of wine cornus fruit, 15-35 weight parts of oriental rhizome, 15-35 weight parts of jujube, 15-35 weight parts of siler, 30-50 weight parts of cypress seed, 15-35 weight parts of Prunus mume seed, 30-50 weight parts of yam, 15-35 weight parts of safflower, 15-35 weight parts of Codonopsis pilosula, 15-35 weight parts of Bupleurum chinense, 10-30 weight parts of Paeonia suffruticosa, 20-40 weight parts of Angelica sinensis, 5-25 weight parts of salt Eucommia ulmoides, 5-25 weight parts of Cyathula officinalis, 10-30 weight parts of Polygonum multiflorum, 20-40 weight parts of hemp seed, 10-30 weight parts of gypsum, and 20-40 weight parts of antler glue.

[0007] In one or more embodiments, the Chinese medicine composition is prepared from the following Chinese medicinal materials in parts by weight:

[0008] 25-35 weight parts of Rehmannia glutinosa, 25-35 weight parts of Poria cocos, 35-45 weight parts of Scutellaria baicalensis, 20-30 weight parts of Atractylodes macrocephala, 35-45 weight parts of Angelica dahurica, 20-30 weight parts of stir-fried Gardenia jasminoides, 20-30 weight parts of wine-brewed Cornus officinalis, 20-30 weight parts of Alisma orientalis, 20-30 weight parts of jujube, 20-30 weight parts of Saposhnikovia divaricata, 35-45 weight parts of Platycladus orientalis seeds, 20-30 weight parts of Prunus mume seeds, 20-30 weight parts of 35-45 weight parts of medicine, 20-30 weight parts of safflower, 20-30 weight parts of Codonopsis pilosula, 20-30 weight parts of Bupleurum chinense, 15-25 weight parts of Paeonia suffruticosa, 25-35 weight parts of Angelica sinensis, 10-20 weight parts of Salt Eucommia ulmoides, 10-20 weight parts of Cyathula officinalis, 15-25 weight parts of Polygonum multiflorum, 20-30 weight parts of Cannabis sativa seed, 15-25 weight parts of gypsum, and 20-30 weight parts of antler glue.

[0009] In one or more embodiments, the Chinese medicine composition is prepared from the following Chinese medicinal materials in parts by weight:

[0010] 30 weight parts of Rehmannia glutinosa, 30 weight parts of Poria, 40 weight parts of Scutellaria baicalensis, 25 weight parts of Atractylodes macrocephala, 40 weight parts of Angelica dahurica, 25 weight parts of stir-fried Gardenia jasminoides, 25 weight parts of wine cornus fruit, 25 weight parts of Alisma orientalis, 25 weight parts of jujube, 25 weight parts of Saposhnikovia divaricata, 40 weight parts of Platycladus orientalis, 25 weight parts of Prunus mume, 40 weight parts of Dioscorea opposita, 25 weight parts of Carthamus tinctorius, 25 weight parts of Codonopsis pilosula, 25 weight parts of Bupleurum chinense, 20 weight parts of Paeonia suffruticosa, 30 weight parts of Angelica sinensis, 15 weight parts of Salt Eucommia ulmoides, 15 weight parts of Cyathula capitata, 20 weight parts of Polygonum multiflorum, 20 weight parts of Fructus hemp, 20 weight parts of Gypsum, and 25 weight parts of Deer Horn Glue.

[0011] In one or more embodiments, the Chinese medicine composition is prepared by the following method:

[0012] The gypsum is boiled with water to obtain a gypsum decoction; the gypsum decoction is mixed with Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica dahurica, stir-fried Gardenia jasminoides, Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seed, Prunus mume seed, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides salt, Cyathula officinalis, Polygonum multiflorum and Fructus hemp, boiled with water for extraction, filtered and obtained an extract;

[0013] The extract is concentrated to a viscous state, the viscous extract is mixed with deer antler glue, filtered, heated and stirred to obtain an ointment.

[0014] In one or more embodiments, the relative density of the viscous extract is 1.2-1.6, such as 1.3, 1.4 or 1.5.

[0015] In one or more embodiments, the antler glue is preheated and boiled into a viscous state.

[0016] In one or more embodiments, the Chinese medicine composition is prepared by the following method:

[0017] (1) decocting gypsum with water to obtain gypsum decoction;

[0018] (2) soaking Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica pubescens, stir-fried Gardenia jasminoides, wine-soaked Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seed, Prunus mume seed, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides, Cyathula officinalis, Polygonum multiflorum, and Fructus hemp in water; preferably, soaking for 1-10 hours (e.g., 2, 3, 4, 5, 6, 7, 8, or 9 hours);

[0019] (3) mixing the gypsum decoction with the medicinal materials soaked in step (2), decocting with water, and filtering to obtain an extract;

[0020] (4) heating and stirring the extract in step (3) until the extract becomes viscous with a relative density of 1.2-1.6 (e.g., 1.3, 1.4 or 1.5);

[0021] (5) The viscous extract in step (4) is mixed with deer antler glue, filtered, heated and stirred to obtain an ointment.

[0022] One or more embodiments of the present application provide a method for preparing a Chinese medicine composition, comprising:

[0023] Take the following medicinal materials by weight:

[0024] 20-40 weight parts of Rehmannia glutinosa, 20-40 weight parts of Poria cocos, 30-50 weight parts of Scutellaria baicalensis, 10-20 weight parts of Atractylodes macrocephala 5-35 weight parts, 30-50 weight parts of Angelica dahurica, 15-35 weight parts of stir-fried Gardenia jasminoides, 15-35 weight parts of wine cornus fruit, 15-35 weight parts of orientalis, 15-35 weight parts of jujube, 15-35 weight parts of Saposhnikovia divaricata, 30-50 weight parts of Platycladus orientalis, 15-35 weight parts of Prunus mume, 30-50 weight parts of yam, 15-35 weight parts of safflower, 15-35 weight parts of Codonopsis pilosula, 15-35 weight parts of Bupleurum chinense, 10-30 weight parts of Paeonia suffruticosa, 20-40 weight parts of Angelica sinensis, 5-25 weight parts of salt Eucommia ulmoides, 5-25 weight parts of Cyathula officinalis, 10-30 weight parts of Polygonum multiflorum, 20-40 weight parts of Cannabis sativa seeds, 10-30 weight parts of gypsum, and 20-40 weight parts of antler glue;

[0025] The gypsum is boiled with water to obtain a gypsum decoction; the gypsum decoction is mixed with Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica dahurica, stir-fried Gardenia jasminoides, Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seed, Prunus mume seed, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides salt, Cyathula officinalis, and Polygonum multiflorum, boiled with water for extraction, and filtered to obtain an extract;

[0026] The extract is concentrated to a viscous state, the viscous extract is mixed with deer antler glue, filtered, heated and stirred to obtain an ointment.

[0027] In one or more embodiments, the following weight portions of medicinal materials are taken:

[0028] 25-35 weight parts of Rehmannia glutinosa, 25-35 weight parts of Poria cocos, 35-45 weight parts of Scutellaria baicalensis, 20-30 weight parts of Atractylodes macrocephala, 35-45 weight parts of Angelica dahurica, 20-30 weight parts of stir-fried Gardenia jasminoides, 20-30 weight parts of wine-brewed Cornus officinalis, 20-30 weight parts of Alisma orientalis, 20-30 weight parts of jujube, 20-30 weight parts of Saposhnikovia divaricata, 35-45 weight parts of Platycladus orientalis seeds, 20-30 weight parts of Prunus mume seeds, 20-30 weight parts of 35-45 parts by weight of Chinese medicine, 20-30 parts by weight of safflower, 20-30 parts by weight of codonopsis pilosula, 20-30 parts by weight of bupleurum chinense, 15-25 parts by weight of peony bark, 25-35 parts by weight of angelica sinensis, 10-20 parts by weight of salt eucommia, 10-20 parts by weight of cyathula, 15-25 parts by weight of radix polygoni multiflori, 20-30 parts by weight of canna seed, 15-25 parts by weight of gypsum, and 20-30 parts by weight of antler glue;

[0029] In one or more embodiments, the following weight portions of medicinal materials are taken:

[0030] 30 parts by weight of Rehmannia root, 30 parts by weight of Poria, 40 parts by weight of Scutellaria baicalensis, 25 parts by weight of Atractylodes macrocephala, 40 parts by weight of Angelica dahurica, 25 parts by weight of stir-fried Gardenia jasminoides, 25 parts by weight of wine-boiled Cornus officinalis, 25 parts by weight of Rhizoma Alismatis, 25 parts by weight of jujube, 25 parts by weight of Saposhnikovia divaricata, 40 parts by weight of Semen Platycladi, 25 parts by weight of Semen Pruni, 40 parts by weight of Dioscorea opposita, 25 parts by weight of Carthamus tinctorius, 25 parts by weight of Codonopsis pilosula, 25 parts by weight of Bupleurum chinense, 20 parts by weight of Paeonia suffruticosa, 30 parts by weight of Angelica sinensis, 15 parts by weight of Eucommia ulmoides, 15 parts by weight of Cyathula capitata, 20 parts by weight of Caulis Polygoni Multiflori, 20 parts by weight of Fructus Cannabis, 20 parts by weight of Gypsum, and 25 parts by weight of Deer Horn Glue;

[0031] In one or more embodiments, the relative density of the viscous extract is 1.2-1.6, such as 1.3, 1.4 or 1.5.

[0032] In one or more embodiments, the antler glue is preheated and boiled into a viscous state.

[0033] In one or more embodiments, the method for preparing the Chinese medicine composition comprises the following:

[0034] (1) decocting gypsum with water to obtain gypsum decoction;

[0035] (2) soaking Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica pubescens, stir-fried Gardenia jasminoides, wine-soaked Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seed, Prunus mume seed, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides, Cyathula officinalis, Polygonum multiflorum, and Fructus hemp in water; preferably, soaking for 1-10 hours (e.g., 2, 3, 4, 5, 6, 7, 8, or 9 hours);

[0036] (3) mixing the gypsum decoction with the medicinal materials soaked in step (2), decocting with water, and filtering to obtain an extract;

[0037] (4) heating and stirring the extract in step (3) until the extract becomes viscous with a relative density of 1.2-1.6 (e.g., 1.3, 1.4 or 1.5);

[0038] (5) The viscous extract in step (4) is mixed with deer antler glue, filtered, heated and stirred to obtain an ointment.

[0039] One or more embodiments of the present application provide the use of the Chinese medicine composition of the present application in the preparation of a medicine for replenishing qi and blood, promoting blood circulation and removing blood stasis, regulating the liver and kidneys and / or strengthening tendons and bones.

[0040] One or more embodiments of the present application provide the use of the Chinese medicine composition of the present application in the preparation of a medicine for replenishing qi and blood, promoting blood circulation and removing blood stasis, regulating the liver and kidneys and / or strengthening tendons and bones after surgery.

[0041] One or more embodiments of the present application provide use of the Chinese medicine composition of the present application in the preparation of a medicament for treating and / or preventing surgical wound infection or poor healing of surgical wounds.

[0042] One or more embodiments of the present application provide the use of the Chinese medicine composition of the present application in the preparation of a medicament for treating and / or preventing decreased resistance, decreased immunity, poor spirits, pain in the surgical area, swelling in the surgical area, congestion in the surgical area, systemic symptoms, poor appetite, nausea, vomiting, constipation, anemia, fatigue, palpitations, irritability, panic, chest tightness, anxiety, dizziness, sweating, forgetfulness, fatigue, insomnia and / or thrombosis after surgery.

[0043] One or more embodiments of the present application provide use of the Chinese medicine composition of the present application in the preparation of a medicament for treating and / or preventing perioperative complications of surgery.

[0044] In one or more embodiments, the complications are decreased resistance, decreased immunity, poor spirits, pain in the surgical area, swelling in the surgical area, congestion in the surgical area, systemic symptoms, poor appetite, nausea, vomiting, constipation, anemia, fatigue, palpitations, irritability, panic, chest tightness, anxiety, dizziness, sweating, forgetfulness, fatigue, insomnia and / or thrombosis.

[0045] In one or more embodiments, the perioperative complications of surgery are perioperative complications of orthopedic surgery.

[0046] In one or more embodiments, the surgery is an orthopedic surgery.

[0047] In one or more embodiments, the orthopedic surgery is a fracture repair surgery or a joint replacement surgery.

[0048] In one or more embodiments, the joint replacement surgery is a knee or hip replacement surgery.

[0049] In one or more embodiments, the thrombus is a deep vein thrombosis of a lower extremity.

[0050] One or more embodiments of the present application provide a Chinese medicine composition and an ointment and a preparation method thereof that can replenish qi and blood for people who need to regulate human functions after surgery and suffer a large loss of qi and blood.

[0051] One or more embodiments of the present application provide a traditional Chinese medicine ointment that can be used to replenish qi and blood, and promote blood circulation and remove blood stasis after surgery, and a preparation method thereof.

[0052] One or more embodiments of the present application provide a Chinese medicine ointment that has the effects of replenishing qi and blood, promoting blood circulation and removing blood stasis, regulating the liver and kidneys, and strengthening tendons and bones. It is mainly used for major orthopedic surgeries, during and after which a large amount of qi and blood is lost, and for people who need to regulate their body functions to replenish qi and blood.

[0053] In one or more embodiments, the Chinese medicine ointment of the present application is prepared from the following components: Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica dahurica, stir-fried Gardenia jasminoides, Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seed, Prunus mume seed, Dioscorea batatas, Safflower, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides salt, Cyathula officinalis, Polygonum multiflorum, Fructus hemp, Gypsum, and Deer antler glue.

[0054] In one or more embodiments, the preparation method of the Chinese medicine composition of the present application comprises:

[0055] (1) Soaking Radix Rehmanniae Preparata, Poria, Radix Scutellariae, Atractylodes macrocephala, Radix Angelicae Pubescentis, stir-fried Gardenia jasminoides, Fructus Corni in wine, Rhizoma Alismatis, jujube, Saposhnikovia divaricata, Semen Platycladi, Semen Pruni, Rhizoma Dioscoreae, Carthamus Tinctorius, Codonopsis pilosula, Radix Bupleuri, Cortex Moutan, Radix Angelicae Sinensis, Eucommia ulmoides, Cyathula officinalis, Caulis Polygoni Multiflori, and Fructus Cannabis in 4-10 times (ratio of the weight of the medicinal materials to the weight of the water (g / g or kg / kg), e.g., 5 times) of water for 1-10 hours;

[0056] (2) decocting gypsum (pre-decocted) with 4-6 times the amount of water (ratio of the weight of the medicinal material to the weight of water (g / g or kg / kg), for example, 5 times the amount) for 0.2-2 hours, and keeping warm for later use;

[0057] (3) boiling the soaked medicinal materials in step (1) and the gypsum solution previously boiled in step (2) for 1-4 times, extracting for 0.5-3 hours respectively, filtering the decoction and keeping warm, combining the two decoctions, and then squeezing the residues, combining the squeezed decoction with the above decoction, and placing the decoction in a medium container and allowing it to settle for no less than 2-10 hours;

[0058] (4) filtering the precipitated drug solution in step (3) through a 100-300 mesh filter cloth, heating all the drug solution to boiling, switching to a low heat (80-100° C.), and continuously stirring the drug solution to a thick paste (relative density of 1.2-1.6);

[0059] (5) Add the pre-treated antler glue to the concentrated liquid medicine, stir continuously until the antler glue is completely melted (mixed evenly), filter, pour into the pot and continue heating, stirring continuously, stirring until the liquid medicine "hangs flag" when the stirring rod is lifted, turn off the heat and stop cooking, and the ointment is ready;

[0060] (6) Divide into dry sterilized containers.

[0061] In one or more embodiments, "flagging" refers to the phenomenon that some semi-fluid thick liquid medicinal materials are shaped like flags and are continuous when picked up. Generally, the melted medicine is picked up with a fixed tool. If the medicine can form a transparent gelatinous layer and does not flow down like a liquid, the "flagging" is successful.

[0062] Chinese medicinal materials in this application:

[0063] Rehmannia glutinosa is a processed product of Rehmannia glutinosa Libosch., a plant of the genus Rehmannia in the family Scrophulariaceae.

[0064] Poria cocos is the dried sclerotium of the Polyporaceae fungus Poria cocos (Schw.) Wolf.

[0065] Scutellaria baicalensis is a processed product of the dried root of Scutellaria baicalensis Georgi, a plant of the Lamiaceae family.

[0066] Atractylodes is the dried rhizome of Atractylodes macrocephala Koidz., a plant of the Asteraceae family.

[0067] Angelica pubescens Maxim.f.biserrata Shanet Yuan is the dried root of Angelica pubescens Maxim.f.biserrata Shanet Yuan, a plant of the Umbelliferae family.

[0068] Fried gardenia, gardenia is the dried mature fruit of Gardenia jasminoides Ellis, a plant of the Rubiaceae family. Fried gardenia is a product prepared by stir-frying gardenia until it turns yellowish brown.

[0069] Wine-cured cornus flesh is a processed product made from the dried mature pulp of Cornus officinalis Sieb.etZucc., a plant of the Cornaceae family. Cornus officinalis fruits are harvested, baked over a slow fire or slightly blanched in boiling water, and the core is removed in time and dried to obtain cornus flesh. Clean cornus flesh is stewed or steamed with wine until the wine is completely absorbed to obtain wine-cured cornus flesh.

[0070] Alisma is the dried tuber of Alisma orientale (Sam.) Juzep. or Alisma plantago-aquatica Linn. of the Oriental Alismataceae family.

[0071] Jujube is the dried mature fruit of Ziziphus jujuba Mill., a plant of the Rhamnaceae family.

[0072] Saposhnikovia is the dried root of Saposhnikovia divaricate (Turcz.) Schischk. of the Umbelliferae family.

[0073] Platyladus orientalis (L.) Franco, a plant of the Cupressaceae family, is a dried mature seed kernel.

[0074] Prunus humilis Bge., Prunus japonica Thunb. or Prunus pedunculata Maxium., are the dried mature seeds of the Rosaceae plants.

[0075] Yam is the dried rhizome of Dioscorea opposite Thunb., a plant of the Dioscoreaceae family.

[0076] Safflower is the dried flower of Carthamus tinctorius L., a plant of the Asteraceae family.

[0077] Codonopsis pilosula is the dried root of Codonopsis pilosula (Franch.) Nannf., Codonopsis pilosula Nannf. var. modesta (Nannf.) LTShen or Codonopsis tangshen Oliv. of the Campanulaceae family.

[0078] Bupleurum chinense DC. or Bupleurumscorzonerifolium Willd., both of which are plants of the Apiaceae family, are dried roots. Bupleurum chinense DC. or Bupleurumscorzonerifolium Willd. Bupleurum chinense DC. is cylindrical or oblong-conical, with a swollen root head, dark brown or light brown surface, longitudinal wrinkles, root scars and lenticels, hard and tough, not easy to break, with fibrous cross section, light brown cortex and yellowish-white wood.

[0079] Paeonia suffruticosa Andr. is the dried root bark of Paeonia suffruticosa Andr., a plant of the Ranunculaceae family.

[0080] Angelica sinensis is the dried root of Angelica sinensis (Oliv.) Diels of the Umbelliferae family.

[0081] Salted Eucommia is a processed product of the dried bark of Eucommia ulmoides Oliv., a plant of the Eucommia family. Take Eucommia pieces or shreds, and stir-fry them with salt until the shreds break and the surface turns black, to obtain Salted Eucommia.

[0082] Sichuan Cyathula is the dried root of Cyathula officinalis Kuan, a plant of the Amaranthaceae family.

[0083] Shouwu vine is the dried vine stem of Polygonum multiflorum Thunb., a plant of the Polygonaceae family.

[0084] Gypsum is a sulfate mineral, gypsum family gypsum, mainly containing hydrated calcium sulfate (CaSO4·2H2O).

[0085] Deer antler glue is a solid glue made by boiling and concentrating the ossified horns of Cervus elaphus Linnaeus or Cervus nippon Temminck, animals of the Cervidae family, or the horn bases that fall off in the spring of the following year after antler sawing.

[0086] Hemp seed is the dried mature fruit of the cannabis plant Cannabis sativa L.

[0087] In one or more embodiments, it is confirmed in long-term clinical application that the composition of the present application is suitable for patients in the perioperative period of knee or hip replacement surgery with liver and kidney deficiency syndrome as the main clinical manifestation, and has a significant effect on improving the clinical symptoms of postoperative patients. The Chinese medicine combination of the present application is an empirical prescription accumulated in long-term clinical application, suitable for long-term postoperative use by patients in the perioperative period of knee or hip replacement surgery and with liver and kidney deficiency syndrome, and has a wide range of clinical application value.

[0088] The Chinese medicine explanation of the prescription and compatibility of the Chinese medicine composition of the present application is as follows:

[0089] Rehmannia root enters the kidney meridian, has a thick taste and is pure yin. It is used to nourish yin and tonify the kidney, replenish essence and benefit marrow, and is the main medicine.

[0090] Cornus officinalis (Cornus officinalis) enters the liver and kidney meridians, nourishes the liver and kidneys, and consolidates the essence and Qi. Chinese yam enters the spleen and kidney meridians, both nourishes the spleen and kidneys, nourishes yin and consolidates essence. Both are ministerial medicines.

[0091] Alisma orientalis can promote diuresis and eliminate kidney turbidity, and can control the disadvantage of Rehmannia glutinosa's greasy effect. Peony bark can eliminate virtual fire and control the warm and astringent effect of Cornus officinalis. Poria can infiltrate dampness and strengthen the spleen. It can be combined with Chinese yam to nourish the spleen and help to promote health. It can be combined with Alisma orientalis to eliminate kidney turbidity and lead virtual heat downward, so that the true yin can be restored. Angelica can promote blood circulation and replenish blood, Scutellaria baicalensis can clear heat and dry dampness, safflower and jujube can remove blood stasis and replenish deficiency, Saposhnikovia divaricata, Atractylodes macrocephala and Polygonum multiflorum can dispel wind and dredge meridians, Eucommia ulmoides can warm the kidney and strengthen yang, Achyranthes bidentata can lead heat and stasis downward, Gypsum can clear heat and remove blood stasis, Bupleurum can reconcile the exterior and interior, soothe the liver and raise yang; Deer antler glue is sweet, salty and warm in nature, enters the liver and kidney meridians, warms and nourishes the liver and kidney, and nourishes the essence and blood. Platycodon grandiflorum, Prunus mume and Fructus hemp can carry blood stasis downward; all the medicines are combined as adjuvants, that is, they assist the monarch and minister, enhance the power of nourishing the liver and kidney, and have the effect of treating concurrent symptoms. The combination of these medicines complements each other and has the effects of nourishing the liver and kidney, promoting blood circulation and removing blood stasis, regulating qi and relieving pain.

[0092] The modern pharmacological studies of the various medicinal materials of the Chinese medicine composition of this application are as follows:

[0093] Rehmannia root: Its chemical components mainly include cyclopentane glycosides, amino acids, phenylethanol glycosides, trace elements, polysaccharides, ionones, etc. It has the following pharmacological effects: affecting the blood system, anti-aging, anti-tumor, enhancing immunity, preventing and treating osteoporosis, lowering blood sugar, improving the cardiovascular system, improving memory, sedation, treating Parkinson's disease, anti-inflammatory, anti-fatigue, etc.

[0094] Cornus officinalis: The main active ingredients are iridoid ether terpenes and their glycosides, triterpenes, flavonoids, tannins, organic acids, polysaccharides, etc. Cornus officinalis can act on many aspects of the body, but its main effects are concentrated on the immune system, circulatory system, nervous system and urinary system. It has multiple pharmacological effects such as anti-tumor, myocardial protection, blood sugar reduction, bone metabolism regulation, neuron protection, anti-oxidation, liver protection, retinol regulation, anti-aging, and anti-inflammatory.

[0095] Chinese Yam: Modern research shows that the main chemical components of Chinese Yam include polysaccharides, amino acids, fatty acids, yam compounds, allantoin, trace elements, starch, etc. It has pharmacological effects such as lowering blood sugar, lowering blood lipids, anti-oxidation, regulating spleen and stomach, anti-tumor, and immune regulation.

[0096] Peony bark: Modern research and application of the chemistry, extraction, analysis and pharmacology of peony bark have found that peony bark contains a large number of complex chemical components such as phenols and phenolic glycosides, monoterpenes and their glycosides, triterpenes, etc., and that peony bark and the paeonol and its glycoside components it contains have strong antibacterial and anti-inflammatory, anti-tumor, anti-arrhythmic, hypoglycemic, immune system activation and cardiovascular protection effects.

[0097] Poria: Poria polysaccharides and triterpenes have been successfully isolated and extracted from Poria, which are the main active ingredients. Studies have found that it has therapeutic effects on the urinary system, digestive system, central nervous system, immune system, etc., and has multiple pharmacological effects such as diuresis, liver protection, sedation, immunity enhancement, anti-inflammatory, anti-tumor and lipid-lowering.

[0098] Alisma: More than 220 compounds have been isolated from Alisma, including triterpenes, sesquiterpenes, diterpenes, sugars, nitrogen-containing compounds, phenylpropanoids, flavonoids, steroids, etc. Pharmacological studies have shown that Alisma alcohol extract, water extract and some monomer components have diuretic, anti-stone and kidney protection, lipid-lowering and liver protection, blood sugar-lowering, anti-cancer, anti-oxidative damage, anti-inflammatory, anti-complement and other effects.

[0099] Deer antler glue: The chemical composition of deer antler glue mainly contains animal protein, various amino acids, peptides, hormones, sugars and a small amount of trace elements. Deer antler glue has the effects of nourishing blood and promoting blood circulation, strengthening yang, anti-inflammatory and analgesic, protecting gastric mucosa, resisting breast hyperplasia, and preventing osteoporosis.

[0100] Angelica: Angelica and its main chemical components have pharmacological effects on multiple systems of the body, including the hematopoietic system, circulatory system, nervous system, and immune system; its main biological activities include hematopoiesis, anti-platelet aggregation, anti-arrhythmia, anti-radiation, anti-tumor, analgesia, smooth muscle regulation, and protection of internal organs.

[0101] Scutellaria baicalensis: It mainly contains flavonoids and their glycosides, terpenoid compounds and volatile oils. It has pharmacological effects such as antipyretic, anti-inflammatory, antimicrobial, anti-tumor and antioxidant. It has certain therapeutic effects on diseases of the digestive system, cardiovascular system, nervous system and other systems.

[0102] Jujube: contains carbohydrates, proteins, alkaloids, triterpenes, saponins, flavonoids, cyclic adenosine monophosphate, cyclic guanosine monophosphate, amino acids, vitamins, minerals, etc. Jujube polysaccharides are an important class of active ingredients. From the perspective of chemical structure, they are divided into water-soluble neutral polysaccharides and acidic polysaccharides. They have the effects of protecting the liver, anti-oxidation, anti-aging, anti-fatigue, lowering blood lipids, regulating blood sugar, anti-inflammatory, improving immunity and anti-tumor, so they have broad application prospects.

[0103] Safflower: Its chemical components include flavonoids, alkaloids, polyacetylene, spermidine, lignans, sesquiterpenes, organic acids, sterols and alkyl diols, among which quinone chalcone is a rare component in other plants. Safflower has a variety of physiological activities, and studies have found that it has certain effects on the cardiovascular and cerebrovascular systems, nervous system, immune system, etc.

[0104] Eucommia ulmoides: The main resources of Eucommia ulmoides are in China, and it is a second-level rare protected plant in my country. The chemical components extracted from Eucommia ulmoides can be divided into lignans, iridoids, flavonoids, phenylpropanoids, terpenes, polysaccharides, etc. according to their structures. Eucommia ulmoides has pharmacological effects such as lowering blood pressure, lowering blood lipids, lowering blood sugar, anti-tumor, antibacterial and antiviral, anti-inflammatory, antioxidant, liver and kidney protection, and anti-osteoporosis.

[0105] Atractylodes macrocephala: contains a variety of active ingredients, has a variety of pharmacological effects, and is widely used in clinical practice. A review of the chemical composition and pharmacological effects of Atractylodes macrocephala in recent years found that the main active ingredients in Atractylodes macrocephala are volatile components, polysaccharides, lactones, flavonoids, glycosides, etc., and the research on the chemical composition of Atractylodes macrocephala is mostly focused on lactones, volatile components and polysaccharides. Atractylodes macrocephala can act on many aspects of the body, but its main effects are concentrated on the gastrointestinal system, immune system and urinary system. It has a variety of pharmacological effects such as anti-tumor, repairing gastric mucosa, anti-inflammatory and analgesic, adjusting water metabolism, protecting the liver, improving memory, regulating lipid metabolism, lowering blood sugar, anti-platelet, antibacterial, and immunomodulation.

[0106] Saposhnikovia divaricata: Its chemical components mainly include volatile oils, chromones and coumarins, which have the effects of dispelling wind, removing dampness, relieving pain and relieving spasm. Modern research believes that its pharmacological effects related to traditional effects are mainly reflected in antipyretic, analgesic and anti-inflammatory aspects, and the main active ingredients are chromone compounds. Based on the summary of the research progress on the material basis and pharmacological effects of Saposhnikovia divaricata, the potential quality markers (Q-markers) of Saposhnikovia divaricata were predicted from the perspectives of chemical component specificity, measurability, correlation between efficacy and properties, authenticity and production standardization. 5-O-methylvisaminol glycosides, cimicifuga, and hyaluronic acid glycosides were preliminarily determined as potential Q-markers that can distinguish the authenticity of Saposhnikovia divaricata, and 5-O-methylvisaminol glycosides, cimicifuga, hyaluronic acid glycosides, and 5-O-methylvisaminol glycosides are potential Q-markers that can distinguish the efficacy of Saposhnikovia divaricata, which can provide a reference for comprehensive control of Saposhnikovia divaricata quality and improvement of Saposhnikovia divaricata quality standards.

[0107] Codonopsis pilosula: It mainly contains sugars, alkaloids, polyacetylene, glycosides and terpenes. It has multiple pharmacological effects such as regulating blood sugar, promoting hematopoietic function, resisting hypoxia, stress, fatigue, enhancing the body's immunity, delaying aging, regulating gastric contraction, protecting gastrointestinal mucosa and anti-ulcer.

[0108] Achyranthes bidentata: The active ingredients are mainly triterpenoid saponins, sterones, polysaccharides and polypeptides. In addition, Achyranthes bidentata also contains chemical components such as organic acids, alkaloids, flavonoids, sterols, amino acids and volatile oils. The pharmacological effects of Achyranthes bidentata were mainly focused on the cardiovascular system, immune system, reproductive system, as well as its anti-tumor, anti-viral, anti-inflammatory and analgesic effects in the early days. In recent years, people have paid more attention to its positive effects on osteoporosis, diabetes, nerve growth and other aspects.

[0109] Angelica dahurica: It mainly contains coumarin, volatile oil and other chemical components, and has pharmacological activities such as antioxidant, anti-inflammatory, anti-tumor, and anti-Alzheimer's. In recent years, domestic and foreign research reports have shown that 94 compounds have been isolated from Angelica dahurica, including 69 coumarin compounds and 25 other compounds.

[0110] Platycladus chinensis kernel: Platycladus chinensis kernel contains effective ingredients such as lipids, amino acids, saponins, terpenes and polysaccharides, which have the effects of calming the nerves, anti-depression, reducing the number of autonomous activities of mice, improving Alzheimer's disease, strengthening intestinal motility, and treating infertility.

[0111] Polygonum multiflorum: It mainly contains anthraquinones (mononuclear anthraquinone and binuclear anthraquinone), diphenylethylenes, flavonoids and polyphenols.

[0112] Gardenia: Contains a large amount of terpenoid compounds, as well as some organic acids, flavonoids, coumarins, volatile oils, saponins, lignans, polysaccharides and other compounds; modern pharmacological research shows that gardenia has multiple pharmacological activities such as anti-inflammatory, antioxidant, choleretic, diuretic, anti-tumor, antipyretic, analgesic, radiation protection, and lipid-lowering.

[0113] Bupleurum: Bupleurum has a complex chemical composition, among which saponins, volatile oils, flavonoids and polysaccharides are the main active ingredients of Bupleurum. It has pharmacological effects such as immunomodulation, anti-depression, liver protection, anti-tumor, antipyretic and anti-inflammatory.

[0114] Gypsum: It is composed of hydrated calcium sulfate (CaSO2·2H2O), which can inhibit the hyperactivity of the thermoregulatory center and produce a strong antipyretic effect. At the same time, the sweating center is also inhibited, so it can relieve fever without sweating and without the disadvantage of damaging body fluids. After being acted upon by gastric acid, part of the gypsum becomes a soluble calcium salt, which is absorbed into the blood in the small intestine. Calcium can inhibit the excitability of nerves and muscles and play an antispasmodic role, and can reduce the permeability of blood vessels. Therefore, gypsum can neutralize gastric acid and prevent dehydration.

[0115] Prunus mume seed: Contains chemical components such as flavonoids, organic acids, triterpenes, etc., has pharmacological effects such as laxative, anti-inflammatory, and analgesic. It is often used clinically to treat diseases such as constipation, edema, and bronchial asthma.

[0116] Hemp seed: Its main active ingredients include a variety of unsaturated fatty acids, proteins, polysaccharides, phenylpropanamide compounds and phenolic compounds. These ingredients play a role in treating diseases by regulating the structure of intestinal flora, reducing the release of inflammatory factors, regulating the activity of various enzymes in the body, and regulating the body's own immune response.

[0117] In one or more embodiments, the present application has one or more of the following advantages:

[0118] The Chinese medicine composition of the present application can nourish qi and blood, promote blood circulation and remove blood stasis, regulate liver and kidney, strengthen tendons and bones, and regulate the body. It can not only nourish qi and blood, regulate liver and kidney, but also comprehensively regulate various organs of the human body and improve the body's immunity.

[0119] The Chinese medicine composition of the present application is easy to use, has stable efficacy, a wide range of treatment, and no toxic or side effects, thus solving the toxic or side effects caused by other similar drugs;

[0120] The Chinese medicine ointment of the present application can replenish qi and blood, promote blood circulation and remove blood stasis, regulate the liver and kidneys, strengthen tendons and bones, and regulate human functions. For example, it can improve immunity, fight bacteria and inflammation, inhibit cancer cells, reduce fat and protect the heart, promote tissue regeneration, promote cell regeneration, and delay aging. For example, in the preparation of anti-rheumatic, inhibit platelet aggregation, improve blood circulation, regulate the immune system, reduce swelling, relieve pain, anti-inflammatory, reduce blood lipids, anti-oxidation, anti-radiation, anti-fatigue, etc.;

[0121] The Chinese medicine composition of the present application can nourish qi and blood, promote blood circulation and remove blood stasis, regulate liver and kidney, and strengthen tendons and bones;

[0122] The Chinese medicine composition of the present application can be used to replenish qi and blood, promote blood circulation and remove blood stasis, regulate the liver and kidneys, and strengthen tendons and bones after surgery; for example, it can be used to replenish qi and blood for people who have lost a lot of qi and blood after major orthopedic surgery and need to regulate human body functions;

[0123] The Chinese medicine composition of the present application exhibits excellent biological effects;

[0124] The method for preparing the Chinese medicine composition of the present application has excellent ointment preparation effect. DETAILED DESCRIPTION

[0125] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0126] Example 1: Preparation of Chinese medicine ointment

[0127] Recipe: 30g Rehmannia root, 30g Poria, 40g Scutellaria baicalensis, 25g Atractylodes macrocephala, 40g Angelica dahurica, 25g stir-fried Gardenia jasminoides, 25g wine-soaked Cornus officinalis, 25g Alisma orientalis, 25g jujube, 25g Saposhnikovia divaricata, 40g Torreya grandis seed, 25g Prunus mume seed, 40g Dioscorea batatas, 25g Safflower, 25g Codonopsis pilosula, 25g Bupleurum chinense, 20g Paeonia suffruticosa, 30g Angelica sinensis, 15g Salt Eucommia ulmoides, 15g Cyathula capitata, 20g Polygonum multiflorum, 20g Cannabis seed, 20g Gypsum (fried first).

[0128] Preparation method:

[0129] (1) Soak Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica pubescens, stir-fried Gardenia jasminoides, wine-boiled Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seed, Prunus mume seed, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides, Cyathula officinalis, Polygonum multiflorum, and Fructus hemp in 4-16 times the amount of water for 1-10 hours;

[0130] (2) Gypsum (pre-decocted): decoct with 4-6 times the amount of water for 0.2-2 hours, and keep warm for later use;

[0131] (3) boiling the soaked medicinal materials in step (1) together with the gypsum decoction in step (2) for 1-4 times, extracting for 0.5-3 hours respectively, filtering the decoction and keeping warm, combining the two decoctions, and then squeezing the residues, combining the squeezed juice into the above decoction, placing in a medium container and leaving to precipitate for not less than 2-10 hours;

[0132] (4) After the precipitated liquid is filtered through a 100-300 mesh filter cloth, all the liquid is heated to boiling, then switched to a low heat, and the liquid is continuously stirred until it becomes a thick paste (relative density is 1.2-1.6);

[0133] (5) Add the pre-treated antler glue to the concentrated liquid medicine, stir continuously until the antler glue is completely melted, filter, pour into the pot and continue heating, stirring continuously, stirring until the liquid medicine "hangs flag" when the stirring rod is lifted, turn off the heat and stop cooking, and the ointment is ready;

[0134] (6) Dispense into dry sterilized containers.

[0135] Example 2: Preparation of Chinese medicine ointment

[0136] Recipe: 45g of Rehmannia root, 45g of Poria cocos, 60g of Scutellaria baicalensis, 30g of Atractylodes macrocephala, 60g of Angelica dahurica, 30g of stir-fried Gardenia jasminoides, 30g of wine-soaked Cornus officinalis, 30g of Alisma orientalis, 30g of jujube, 30g of Saposhnikovia divaricata, 60g of Torreya grandis seed, 30g of Prunus mume seed, 60g of Dioscorea batatas, 30g of Safflower, 30g of Codonopsis pilosula, 30g of Bupleurum chinense, 30g of Moutan bark, 30g of Angelica sinensis, 20g of Salt Eucommia ulmoides, 20g of Cyathula capitata, 20g of Polygonum multiflorum, 20g of Cannabis seed, and 20g of Gypsum (fried first).

[0137] Preparation method:

[0138] (1) Soak Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica pubescens, stir-fried Gardenia jasminoides, wine-boiled Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seed, Prunus mume seed, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides, Cyathula officinalis, Polygonum multiflorum, and Fructus hemp in 4-16 times the amount of water for 1-10 hours;

[0139] (2) Gypsum (pre-decocted): decoct with 4-6 times the amount of water for 0.2-2 hours, and keep warm for later use;

[0140] (3) boiling the soaked medicinal materials in step (1) and the gypsum solution previously boiled in step (2) for 1-4 times, extracting for 0.5-3 hours respectively, filtering the decoction and keeping warm, combining the two decoctions, and then squeezing the residues, combining the squeezed decoction with the above decoction, and placing the decoction in a medium container and allowing it to settle for no less than 2-10 hours;

[0141] (4) After the precipitated liquid is filtered through a 100-300 mesh filter cloth, all the liquid is heated to boiling, then switched to a low heat, and the liquid is continuously stirred until it becomes a thick paste (relative density is 1.2-1.6);

[0142] (5) Add the pre-treated antler glue to the concentrated liquid medicine, stir continuously until the antler glue is completely melted, filter, pour into the pot and continue heating, stirring continuously, stirring until the liquid medicine "hangs flag" when the stirring rod is lifted, turn off the heat and stop cooking, and the ointment is ready;

[0143] (6) Dispense into dry sterilized containers.

[0144] Example 3: Preparation of Chinese medicine ointment

[0145] Recipe: 5g of Rehmannia root, 5g of Poria cocos, 6g of Scutellaria baicalensis, 2.5g of Atractylodes macrocephala, 6g of Angelica dahurica, 2.5g of stir-fried Gardenia jasminoides, 2.5g of Cornus officinalis, 2.5g of Alisma orientalis, 2.5g of jujube, 2.5g of Saposhnikovia divaricata, 7g of Torreya grandis seed, 3g of Prunus mume seed, 7g of Dioscorea batatas, 2.5g of Carthamus tinctorius, 2.5g of Codonopsis pilosula, 2.5g of Bupleurum chinense, 3g of Paeonia suffruticosa, 5g of Angelica sinensis, 3g of Eucommia ulmoides, 3g of Cyathula capitata, 7g of Polygonum multiflorum, 7g of Cannabis sativa seed, and 6g of Gypsum (fried first).

[0146] Preparation method:

[0147] (1) Soak Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica pubescens, stir-fried Gardenia jasminoides, wine-boiled Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seed, Prunus mume seed, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides, Cyathula officinalis, Polygonum multiflorum, and Fructus hemp in 4-16 times the amount of water for 1-10 hours;

[0148] (2) Gypsum (pre-decocted): decoct with 4-6 times the amount of water for 0.2-2 hours, and keep warm for later use;

[0149] (3) The medicinal materials soaked in step (1) are decocted with the gypsum decoction in step (2) for 1-4 times, respectively, and the decoctions are extracted for 0.5-3 hours, the decoctions are filtered and stored warm, the two decoctions are combined, the residues are fully squeezed, the squeezed decoction is added to the above decoction, and the decoctions are placed in a medium container and allowed to settle for no less than 2-10 hours;

[0150] (4) After the precipitated liquid is filtered through a 100-300 mesh filter cloth, all the liquid is heated to boiling, then switched to a low heat, and the liquid is continuously stirred until it becomes a thick paste (relative density is 1.2-1.6);

[0151] (5) Add the pre-treated antler glue to the concentrated liquid medicine, stir continuously until the antler glue is completely melted, filter, pour into the pot and continue heating, stirring continuously, stirring until the liquid medicine "hangs flag" when the stirring rod is lifted, turn off the heat and stop cooking, and the ointment is ready;

[0152] (6) Dispense into dry sterilized containers.

[0153] Example 4: Preparation of Chinese medicine ointment

[0154] Recipe: 75g of Rehmannia root, 75g of Poria cocos, 100g of Scutellaria baicalensis, 50g of Atractylodes macrocephala, 100g of Angelica dahurica, 50g of stir-fried Gardenia jasminoides, 50g of Cornus officinalis, 50g of Alisma orientalis, 50g of jujube, 50g of Saposhnikovia divaricata, 100g of Torreya grandis seed, 50g of Prunus mume seed, 100g of Dioscorea batatas, 50g of Safflower, 50g of Codonopsis pilosula, 50g of Bupleurum chinense, 50g of Paeonia suffruticosa, 75g of Angelica sinensis, 50g of Salt Eucommia ulmoides, 50g of Cyathula capitata, 50g of Polygonum multiflorum, 50g of Cannabis seed, and 50g of Gypsum (fried first).

[0155] Preparation method: (1) Soak Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica pubescens, stir-fried Gardenia jasminoides, wine-soaked Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seed, Prunus mume seed, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides salt, Cyathula officinalis, Polygonum multiflorum, and Cannabis sativa seed in 4-16 times the amount of water for 1-10 hours;

[0156] (2) Gypsum (pre-decocted): decoct with 4-6 times the amount of water for 0.2-2 hours, and keep warm for later use;

[0157] (3) The soaked medicinal materials in step (1) are decocted together with the gypsum decoction in step (2) for 1-4 times, and the extraction is performed for 0.5-3 hours respectively. The decoction is filtered and stored warm, and the two decoctions are combined. The medicinal residues are fully squeezed, and the squeezed medicinal juice is added to the above-mentioned medicinal solution, and placed in a medium container and allowed to settle for no less than 2-10 hours;

[0158] (4) After the precipitated liquid is filtered through a 100-300 mesh filter cloth, all the liquid is heated to boiling, then switched to a low heat, and the liquid is continuously stirred until it becomes a thick paste (relative density is 1.2-1.6);

[0159] (5) Add the pre-treated antler glue to the concentrated liquid medicine, stir continuously until the antler glue is completely melted, filter, pour into the pot and continue heating, stirring continuously, stirring until the liquid medicine "hangs flag" when the stirring rod is lifted, turn off the heat and stop cooking, and the ointment is ready;

[0160] (6) Dispense into dry sterilized containers.

[0161] Clinical Trials

[0162] The beneficial effects of the present invention are described below in conjunction with clinical experimental data.

[0163] 1. General information:

[0164] A total of 140 patients who underwent joint replacement surgery were collected from January 2020 to January 2024. Among them, the clinical manifestations were decreased resistance after surgery, poor immunity, poor spirits, local pain in the surgical area, swelling, subcutaneous congestion, systemic symptoms, poor appetite, nausea, vomiting, constipation, anemia, fatigue, palpitations, restlessness, anxiety, dizziness, forgetfulness, fatigue and insomnia. Two or more symptoms, aged 50-80 years old, and the condition lasted for 1 month to 1 year. They were randomly divided into: 70 cases in the treatment group and 70 cases in the control group. There was no significant difference in age and other data between the two groups, and they were comparable.

[0165] Gender:

[0166]

[0167] Note: × 2 The test showed that there was no significant difference in gender between the two groups (P>0.05), and they were comparable.

[0168] age:

[0169]

[0170] Note: The age distribution of the two groups was compared by ×2 test, P=0.267>0.05, and there was no significant difference in age distribution between the two groups, so they were comparable.

[0171] Course of disease:

[0172]

[0173] Note: There was no significant difference in the course of disease between the two groups of patients (P=0.086>0.05), so they were comparable.

[0174] 2. How to take the medicine:

[0175] Treatment group: took the ointment described in Example 1 twice a day, 5-8 grams each time.

[0176] Control group: Take Bazhen Decoction, 1 to 2 times a day, 10g each time. Prescription ingredients: Ginseng, Atractylodes macrocephala, White Poria, Angelica sinensis, Chuanxiong, White Peony Root, Rehmannia glutinosa, Roasted Licorice. Effect: Invigorates Qi and replenishes blood, mainly treats Qi and blood deficiency. Source: Ruizhutang Experience Prescription.

[0177] 3. Efficacy criteria

[0178] Recovery: All clinical symptoms disappear.

[0179] Improvement: Clinical symptoms are alleviated and the condition is under control.

[0180] Ineffective: Clinical symptoms did not improve or worsen significantly.

[0181] The effectiveness rate is calculated based on the number of cures and improvements.

[0182] 4. Treatment Statistical Results

[0183] Comparison of WOMAC knee function assessment scores between the two groups before and after treatment: (mean ± standard deviation)

[0184]

[0185] Note: There was no significant difference in WOMAC knee function assessment scores between the treatment group and the control group before treatment (t=0.436, P=0.664>0.05); there was a significant difference in WOMAC knee function assessment scores before and after treatment in the treatment group (t=7.973, P=0.000<0.05); there was a significant difference in WOMAC knee function assessment scores before and after treatment in the control group (t=5.599, P=0.000<0.05); there was a significant difference in WOMAC knee function assessment scores between the treatment group and the control group after treatment (t=-2.502, P=0.020<0.05); both the treatment group and the experimental group were effective in alleviating functional impairment, and the treatment group was better than the control group in improving functional impairment.

[0186] Comparison of VAS scores of knee pain between the two groups before and after treatment (mean ± SD)

[0187]

[0188] Note: There was no significant difference in VAS scores of knee joint pain between the treatment group and the control group before treatment (t=1.178, P=0.243>0.05); there was a significant difference in VAS scores of knee joint pain before and after treatment in the treatment group (t=8.733, P=0.000<0.05); there was a significant difference in VAS scores of knee joint pain before and after treatment in the control group (t=6.113, P=0.000<0.05); there was a significant difference in VAS scores of knee joint pain between the treatment group and the control group after treatment (t=2.146, P=0.036<0.05); both the treatment group and the experimental group were effective in relieving knee joint pain, and the treatment group was better than the control group in improving knee joint pain.

[0189] Comparison of clinical efficacy between the two groups after treatment:

[0190]

[0191] Note: Zc=2.12, check the standard normal distribution table, and get P=0.02<0.05, indicating that the difference in the efficacy of drugs in the treatment group and the control group on knee arthritis is statistically significant. Combined with the above table, it can be seen that the efficacy of the treatment group is better than that of the control group.

[0192] After taking the Chinese medicine composition of the present application, questionnaires and blood index tests showed that in terms of pain management: the proportion of severe pain decreased by 30%, the amount of morphine decreased by 27%, the use of other analgesics decreased by 4%, and adverse reactions decreased by 19%; blood tests: red blood cells increased by 11.6%, hemoglobin increased by 5.3%, hematocrit increased by 14.2%, bleeding decreased by 8%, blood transfusion decreased by 6.3%, and D-2 polymer decreased by 18%; the incidence of nausea and vomiting decreased by 25%; swelling time decreased by 15.2%, and the incidence of venous thrombosis decreased by 1.5%.

[0193] Monitor liver function and coagulation-related indicators one month after taking the Chinese medicine composition of the present application:

[0194]

[0195]

[0196]

[0197]

[0198] No cases of liver or kidney damage were found, and the drug had no effect on coagulation factors, proving that it is safe and effective.

[0199] Typical Case Studies

[0200] Patient Case 1

[0201] Male, 67 years old, diagnosed during hospitalization: osteoarthritis of both knees, prostatitis with kidney deficiency, accompanied by insomnia, poor appetite, and dizziness. The day after the knee replacement surgery, he developed abdominal distension, constipation, swelling, congestion, and pain around the surgery area. He took the ointment of this application the day after the surgery and recovered after 25 days.

[0202] Patient Case 2

[0203] Female, 80 years old, admitted to hospital with diagnosis: right knee osteoarthritis, hypertension, right knee joint pain for 10 years, pain accompanied by long-term insomnia, anxiety, anemia symptoms. On the third day after right knee replacement surgery, she started taking the Chinese medicine composition of the present application. After taking the medicine for 30 days, the anemia and insomnia symptoms improved.

[0204] Patient Case 3

[0205] Female, 77 years old, diagnosed with right knee osteoarthritis during hospitalization, accompanied by poor appetite and dizziness. On the third day after right knee replacement surgery, she developed swelling, congestion and pain around the surgery area. On the fourth day after surgery, she took the Chinese medicine composition of the present application. After taking the medicine for 1 week, the swelling and congestion around the surgery area improved, and after 20 days, the dizziness and poor appetite were cured.

[0206] Patient Case 4

[0207] Female, 72 years old, diagnosed with left knee osteoarthritis and type 2 diabetes during hospitalization, had left knee replacement, and had congestion around the surgical area on the second day after surgery, accompanied by poor appetite, constipation, and vomiting. On the second day after surgery, she took the Chinese medicine composition of the present application. After taking the medicine for 3 days, the poor appetite, vomiting, and constipation were relieved, and she recovered after 30 days.

[0208] Patient Case 5

[0209] Female, 64 years old, diagnosed with left knee osteoarthritis accompanied by severe anxiety during hospitalization, had left knee replacement, and had congestion around the surgical area on the second day after surgery, accompanied by poor appetite, constipation, sweating, and insomnia. She took the Chinese medicine composition of the present application on the third day after surgery and recovered after taking the medicine for 15 days.

[0210] Patient Case 6

[0211] Male, 68 years old, diagnosed with osteoarthritis of both knees during hospitalization, underwent bilateral knee replacement, and experienced swelling around the surgical area and subcutaneous congestion on the second day after surgery, accompanied by poor appetite and constipation. He took the Chinese medicine composition of the present application on the second day after surgery and recovered after taking the medicine for 20 days.

[0212] Patient Case 7

[0213] Male, 63 years old, diagnosed with osteoarthritis of both knees during hospitalization, accompanied by severe overweight, underwent left knee replacement, and developed subcutaneous congestion around the surgical area, pain, sweating, and insomnia on the second day after surgery. He took the Chinese medicine composition of the present application on the third day after surgery. After taking the medicine for 30 days, he got better.

[0214] Patient Case 8

[0215] Female, 65 years old, diagnosed with osteoarthritis of both knees, anxiety disorder, neurosis, accompanied by anorexia and dizziness during hospitalization. On the third day after left knee replacement surgery, she developed pain in the surgical area, insomnia, panic, chest tightness and other symptoms. On the fourth day after surgery, she took the Chinese medicine composition of the present application. After taking the medicine for 2 weeks, the related symptoms improved significantly.

[0216] Patient Case 9

[0217] Female, 72 years old, diagnosed with femoral head necrosis during hospitalization, underwent total hip replacement surgery after hospitalization. The patient had mild cough, anxiety and other symptoms after surgery. After taking the Chinese medicine composition of the present application for one week, the cough was relieved and the symptoms of lung infection disappeared. The patient's mental state improved and recovered well.

[0218] Patient Case 10

[0219] Male, 65 years old, diagnosed with left femoral neck fracture during hospitalization, underwent total hip replacement surgery after hospitalization, and the patient developed leg edema, limited mobility, poor appetite, abdominal distension, etc. after the operation. After taking the Chinese medicine composition of the present application for one week, the patient's edema was significantly reduced, leg mobility was restored, mental state improved, and abdominal distension was reduced.

[0220] Patient Case 11

[0221] A 74-year-old male patient was diagnosed with left humeral fracture during hospitalization and underwent internal fixation surgery for the humeral fracture. After the surgery, the patient felt pain all over the body, increased wound pain, and poor sleep. After taking the Chinese medicine composition of the present application for one week, the patient's sleep quality improved and symptoms of generalized anxiety were alleviated.

[0222] 5. Conclusion

[0223] Taking the Chinese medicine composition of the present application has a good effect on decreased resistance and poor immunity after surgery, deep vein thrombosis, infection, fever, poor appetite, nausea, vomiting, constipation, anemia, fatigue, palpitations, irritability, anxiety, dizziness, forgetfulness, fatigue and insomnia. For mild patients, taking the medicine for 3-5 days can improve the symptoms, and taking it for about 2 weeks can cure it. For moderate or severe patients, taking the medicine for about a week can improve the symptoms, and taking it for three to five weeks can cure it. In addition, the Chinese medicine composition of the present application has no toxic and side effects such as liver and kidney damage.

Claims

1. A Chinese medicine composition, which is prepared from the following Chinese medicinal materials in parts by weight: 20-40 weight parts of Rehmannia root, 20-40 weight parts of Poria, 30-50 weight parts of Scutellaria baicalensis, 15-35 weight parts of Atractylodes macrocephala, 30-50 weight parts of Angelica dahurica, 15-35 weight parts of stir-fried Gardenia jasminoides, 15-35 weight parts of wine-boiled Cornus officinalis, 15-35 weight parts of Alisma orientalis, 15-35 weight parts of jujube, 15-35 weight parts of Saposhnikovia divaricata, 30-50 weight parts of Platycladus orientalis seeds, 15-35 weight parts of Prunus mume seeds, 30-50 parts by weight of yam, 15-35 parts by weight of safflower, 15-35 parts by weight of codonopsis pilosula, 15-35 parts by weight of bupleurum chinense, 10-30 parts by weight of peony bark, 20-40 parts by weight of angelica sinensis, 5-25 parts by weight of salt eucommia bark, 5-25 parts by weight of cyathula, 10-30 parts by weight of Polygonum multiflorum, 20-40 parts by weight of hemp seed, 10-30 parts by weight of gypsum, and 20-40 parts by weight of antler glue; Preferably, the Chinese medicine composition is prepared from the following Chinese medicinal materials in parts by weight: 25-35 weight parts of Rehmannia glutinosa, 25-35 weight parts of Poria cocos, 35-45 weight parts of Scutellaria baicalensis, 20-30 weight parts of Atractylodes macrocephala, 35-45 weight parts of Angelica dahurica, 20-30 weight parts of stir-fried Gardenia jasminoides, 20-30 weight parts of wine-brewed Cornus officinalis, 20-30 weight parts of Alisma orientalis, 20-30 weight parts of jujube, 20-30 weight parts of Saposhnikovia divaricata, 35-45 weight parts of Platycladus orientalis seeds, 20-30 weight parts of Prunus mume seeds, 20-30 weight parts of 35-45 parts by weight of Chinese medicine, 20-30 parts by weight of safflower, 20-30 parts by weight of codonopsis pilosula, 20-30 parts by weight of bupleurum chinense, 15-25 parts by weight of peony bark, 25-35 parts by weight of angelica sinensis, 10-20 parts by weight of salt eucommia, 10-20 parts by weight of cyathula, 15-25 parts by weight of radix polygoni multiflori, 20-30 parts by weight of canna seed, 15-25 parts by weight of gypsum, and 20-30 parts by weight of antler glue; More preferably, the Chinese medicine composition is prepared from the following Chinese medicinal materials in parts by weight: 30 weight parts of Rehmannia glutinosa, 30 weight parts of Poria, 40 weight parts of Scutellaria baicalensis, 25 weight parts of Atractylodes macrocephala, 40 weight parts of Angelica dahurica, 25 weight parts of stir-fried Gardenia jasminoides, 25 weight parts of wine cornus fruit, 25 weight parts of Alisma orientalis, 25 weight parts of jujube, 25 weight parts of Saposhnikovia divaricata, 40 weight parts of Platycladus orientalis, 25 weight parts of Prunus mume, 40 weight parts of Dioscorea opposita, 25 weight parts of Carthamus tinctorius, 25 weight parts of Codonopsis pilosula, 25 weight parts of Bupleurum chinense, 20 weight parts of Paeonia suffruticosa, 30 weight parts of Angelica sinensis, 15 weight parts of Salt Eucommia ulmoides, 15 weight parts of Cyathula capitata, 20 weight parts of Polygonum multiflorum, 20 weight parts of Fructus hemp, 20 weight parts of Gypsum, and 25 weight parts of Deer Horn Glue.

2. The Chinese medicine composition according to claim 1, which is prepared by the following method: The gypsum is boiled with water to obtain a gypsum decoction; the gypsum decoction is mixed with Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica dahurica, stir-fried Gardenia jasminoides, Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seed, Prunus mume seed, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides salt, Cyathula officinalis, Polygonum multiflorum and Fructus hemp, boiled with water for extraction, filtered and obtained an extract; The extract is concentrated to a viscous state, the viscous extract is mixed with antler glue, filtered, heated and stirred to obtain an ointment; Preferably, the relative density of the viscous extract is 1.2-1.6; preferably, the antler glue is pre-heated and boiled into a viscous state.

3. The Chinese medicine composition according to claim 1, which is prepared by the following method: (1) decocting gypsum with water to obtain gypsum decoction; (2) soaking Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica pubescens, stir-fried Gardenia jasminoides, wine-soaked Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seeds, Prunus mume seeds, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides salt, Cyathula officinalis, Polygonum multiflorum, and Fructus hemp in water; preferably, soaking for 1-10 hours; (3) mixing the gypsum decoction with the medicinal materials soaked in step (2), decocting with water, and filtering to obtain an extract; (4) heating and stirring the extract in step (3) until it becomes viscous with a relative density of 1.2-1.6; (5) The viscous extract in step (4) is mixed with deer antler glue, filtered, heated and stirred to obtain an ointment.

4. A method for preparing a Chinese medicine composition, comprising: Take the following medicinal materials by weight: 20-40 weight parts of Rehmannia glutinosa, 20-40 weight parts of Poria cocos, 30-50 weight parts of Scutellaria baicalensis, 10-20 weight parts of Atractylodes macrocephala 5-35 weight parts, 30-50 weight parts of Angelica dahurica, 15-35 weight parts of stir-fried Gardenia jasminoides, 15-35 weight parts of wine cornus fruit, 15-35 weight parts of orientalis, 15-35 weight parts of jujube, 15-35 weight parts of Saposhnikovia divaricata, 30-50 weight parts of Platycladus orientalis, 15-35 weight parts of Prunus mume, 30-50 weight parts of yam, 15-35 weight parts of safflower, 15-35 weight parts of Codonopsis pilosula, 15-35 weight parts of Bupleurum chinense, 10-30 weight parts of Paeonia suffruticosa, 20-40 weight parts of Angelica sinensis, 5-25 weight parts of salt Eucommia ulmoides, 5-25 weight parts of Cyathula officinalis, 10-30 weight parts of Polygonum multiflorum, 20-40 weight parts of Cannabis sativa seeds, 10-30 weight parts of gypsum, and 20-40 weight parts of antler glue; Preferably, 25-35 parts by weight of Rehmannia glutinosa, 25-35 parts by weight of Poria cocos, 35-45 parts by weight of Scutellaria baicalensis, 20-30 parts by weight of Atractylodes macrocephala, 35-45 parts by weight of Angelica dahurica, 20-30 parts by weight of stir-fried Gardenia jasminoides, 20-30 parts by weight of wine-boiled Cornus officinalis, 20-30 parts by weight of Alisma orientalis, 20-30 parts by weight of jujube, 20-30 parts by weight of Saposhnikovia divaricata, 35-45 parts by weight of Platycladus orientalis, and 20-30 parts by weight of Prunus mume , 35-45 parts by weight of yam, 20-30 parts by weight of safflower, 20-30 parts by weight of codonopsis pilosula, 20-30 parts by weight of bupleurum, 15-25 parts by weight of peony bark, 25-35 parts by weight of angelica, 10-20 parts by weight of salt eucommia, 10-20 parts by weight of cyathula, 15-25 parts by weight of Polygonum multiflorum, 20-30 parts by weight of hemp seed, 15-25 parts by weight of gypsum, and 20-30 parts by weight of antler glue; More preferably, 30 parts by weight of Rehmannia glutinosa, 30 parts by weight of Poria cocos, 40 parts by weight of Scutellaria baicalensis, 25 parts by weight of Atractylodes macrocephala, 40 parts by weight of Angelica dahurica, 25 parts by weight of stir-fried Gardenia jasminoides, 25 parts by weight of wine-boiled Cornus officinalis, 25 parts by weight of Rhizoma Alismatis, 25 parts by weight of jujube, 25 parts by weight of Saposhnikovia divaricata, 40 parts by weight of Platycladus orientalis, 25 parts by weight of Semen Platycladi, 25 parts by weight of Semen Pruni, 40 parts by weight of Dioscorea opposita, 25 parts by weight of Carthamus tinctorius, 25 parts by weight of Codonopsis pilosula, 25 parts by weight of Bupleurum chinense, 20 parts by weight of Paeonia suffruticosa, 30 parts by weight of Angelica sinensis, 15 parts by weight of Eucommia ulmoides, 15 parts by weight of Cyathula capitata, 20 parts by weight of Caulis Polygoni Multiflori, 20 parts by weight of Fructus Cannabis, 20 parts by weight of Gypsum, and 25 parts by weight of Deer Horn Glue; The gypsum is boiled with water to obtain a gypsum decoction; the gypsum decoction is mixed with Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica dahurica, stir-fried Gardenia jasminoides, Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seed, Prunus mume seed, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides salt, Cyathula officinalis, and Polygonum multiflorum, boiled with water for extraction, and filtered to obtain an extract; The extract is concentrated to a viscous state, the viscous extract is mixed with antler glue, filtered, heated and stirred to obtain an ointment; Preferably, the relative density of the viscous extract is 1.2-1.6; Preferably, the deer antler glue is preheated and boiled into a viscous state.

5. The method of claim 4, comprising: (1) decocting gypsum with water to obtain gypsum decoction; (2) soaking Rehmannia root, Poria, Scutellaria baicalensis, Atractylodes macrocephala, Angelica pubescens, stir-fried Gardenia jasminoides, wine-soaked Cornus officinalis, Alisma orientalis, jujube, Saposhnikovia divaricata, Platycladus orientalis seeds, Prunus mume seeds, Dioscorea opposita, Carthamus tinctorius, Codonopsis pilosula, Bupleurum chinense, Paeonia suffruticosa, Angelica sinensis, Eucommia ulmoides salt, Cyathula officinalis, Polygonum multiflorum, and Fructus hemp in water; preferably, soaking for 1-10 hours; (3) mixing the gypsum decoction with the medicinal materials soaked in step (2), decocting with water, and filtering to obtain an extract; (4) heating and stirring the extract in step (3) until it becomes viscous with a relative density of 1.2-1.6; (5) The viscous extract in step (4) is mixed with deer antler glue, filtered, heated and stirred to obtain an ointment.

6. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicine for replenishing qi and blood, promoting blood circulation and removing blood stasis, regulating liver and kidney and / or strengthening tendons and bones.

7. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for replenishing qi and blood, promoting blood circulation and removing blood stasis, regulating liver and kidney and / or strengthening tendons and bones after surgery; preferably, the surgery is an orthopedic surgery; more preferably, the orthopedic surgery is a fracture repair surgery or a joint replacement surgery; more preferably, the joint replacement surgery is a knee joint or hip joint replacement surgery.

8. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating and / or preventing surgical wound infection or poor surgical wound healing; preferably, the surgery is an orthopedic surgery; more preferably, the orthopedic surgery is a fracture repair surgery or a joint replacement surgery; more preferably, the joint replacement surgery is a knee or hip replacement surgery.

9. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating and / or preventing decreased resistance, decreased immunity, poor spirits, pain in the surgical area, swelling in the surgical area, congestion in the surgical area, systemic symptoms, poor appetite, nausea, vomiting, constipation, anemia, fatigue, palpitations, irritability, panic, chest tightness, anxiety, dizziness, sweating, forgetfulness, fatigue, insomnia and / or thrombosis after surgery; preferably, the surgery is an orthopedic surgery; more preferably, the orthopedic surgery is a fracture repair surgery or a joint replacement surgery; more preferably, the joint replacement surgery is a knee or hip replacement surgery; more preferably, the thrombus is a deep vein thrombosis of the lower extremities.

10. Use of the Chinese medicine composition according to any one of claims 1-3 in the preparation of a medicament for treating and / or preventing perioperative complications of surgery; the complications are decreased resistance, decreased immunity, poor spirits, pain in the surgical area, swelling in the surgical area, congestion in the surgical area, systemic symptoms, poor appetite, nausea, vomiting, constipation, anemia, fatigue, palpitations, irritability, panic, chest tightness, anxiety, dizziness, sweating, forgetfulness, fatigue, insomnia and / or thrombosis; preferably, the thrombosis is deep vein thrombosis of the lower extremities; preferably, the perioperative complications of surgery are perioperative complications of orthopedic surgery; more preferably, the orthopedic surgery is fracture repair surgery or joint replacement surgery; more preferably, the joint replacement surgery is knee or hip replacement surgery.

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