Preparation method of traditional Chinese medicine composition for reducing blood pressure

Abstract

A preparation method of a traditional Chinese medicine composition for reducing blood pressure comprises the following raw materials: fresh plantain herb, fresh motherwort, fresh herba siegesbeckiae, fresh radix paeoniae rubra, fresh selfheal, fresh rhizoma polygonati, fresh rehmannia and lumbricus, and comprises the following steps: (1) selecting the fresh plantain herb, the fresh motherwort, the fresh herba siegesbeckiae, the fresh radix paeoniae rubra, the fresh selfheal, the fresh rhizoma polygonati and the fresh rehmannia, cleaning, cutting into sections while fresh, adding water, breaking walls, and filtering to obtain filtrate; centrifuging to obtain supernate; (2) performing ultrafiltration, concentration, freeze-drying and crushing on a product obtained in the step (1); (3) cleaning, cutting, freeze-drying, crushing and sieving the earthworms; and (4) uniformly mixing the materials obtained in the steps (2) and (3), performing vacuum packaging, and performing sterilization to obtain the traditional Chinese medicine composition for reducing blood pressure, the traditional Chinese medicine composition has the effects of clearing heat, calming liver, activating blood and inducing diuresis, is effectively used for treating hypertension, reducing complications and effectively controlling blood pressure, the preparation method is convenient to operate, safe and environment-friendly, active ingredients in the traditional Chinese medicines can be reserved to the greatest extent, and the economic and social benefits are huge.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a method for preparing a blood pressure lowering traditional Chinese medicine composition. Background Art

[0002] Hypertension is a common cardiovascular disease, a clinical syndrome characterized by a sustained increase in circulating arterial blood pressure. It is also the main risk factor for diseases such as stroke, coronary heart disease, and heart failure. Typical symptoms of hypertension include headache, fatigue or restlessness, arrhythmia, palpitations, and tinnitus. However, many patients with hypertension may have other complications without any symptoms, such as stroke, blurred vision, loss of consciousness, and amnesia, which seriously endanger human health and cannot be cured, requiring lifelong medication. According to statistics, the prevalence, treatment rate, and control rate of hypertension in people over 18 years old in my country are 46.9%, 40.7%, and 15.3%, respectively. At present, most clinical treatments are with Western medicine, including angiotensin-converting enzyme inhibitors, calcium antagonists, vasodilators, and antihypertensive drugs acting on the sympathetic nervous system. However, long-term use of Western medicine can lead to multiple adverse reactions such as electrolyte disorder, bradycardia, and renal fibrosis. Traditional Chinese medicine has the advantages of multiple targets, good antihypertensive effect, good safety, and few adverse effects in the treatment of hypertension.

[0003] In traditional Chinese medicine, hypertension belongs to the categories of "dizziness", "headache", "wind vertigo" and "tinnitus". The "Guidelines for the Diagnosis and Treatment of Hypertension in Traditional Chinese Medicine" summarizes it into 7 types of traditional Chinese medicine syndromes, including liver yang hyperactivity, phlegm and dampness congestion, blood stasis blocking the orifices, yin deficiency and yang hyperactivity, yin and yang deficiency, phlegm and fluid retention, and kidney yin deficiency, and the yin deficiency and yang hyperactivity type is the most common. Fresh Chinese medicine has unique efficacy in the clinical treatment of critical and difficult diseases, and its efficacy is better than that of dry products. So whether fresh medicinal materials can be used to develop a Chinese medicine composition for lowering blood pressure has not been publicly reported so far. Summary of the invention

[0004] In view of the above situation, in order to overcome the deficiencies of the prior art, the purpose of the present invention is to provide a method for preparing a Chinese medicine composition for lowering blood pressure, which can effectively control blood pressure and solve the problem of medication for treating Yin deficiency and Yang hyperactivity type hypertension.

[0005] The technical solution solved by the present invention is a method for preparing a Chinese medicine composition for lowering blood pressure. The Chinese medicine composition is composed of the following raw materials in parts by weight: 30-100 parts of fresh plantain, 30-100 parts of fresh motherwort, 30-100 parts of fresh siegetable herb, 30-70 parts of fresh red peony root, 30-100 parts of fresh selfheal, 30-100 parts of fresh polygonatum, 30-70 parts of fresh rehmannia root and 2-5 parts of earthworm. The preparation method is:

[0006] (1) The fresh plantain is selected and washed 1 to 3 times, cut into segments while fresh, and added with water 1 to 5 times the weight volume of the original drug, where the weight volume refers to the solid in kg and the liquid in L (the same below), broken for 1 to 10 minutes, filtered, and the filtrate is centrifuged at 2000 to 8000 r / min for 5 to 30 minutes to obtain the first supernatant; then water is added and the broken and centrifuged are repeated 1 to 4 times according to the above method to obtain the second to fifth supernatants, and the supernatants of each time are combined;

[0007] Fresh red peony root is selected and washed 1 to 3 times, cut into sections or slices while fresh, add water 1 to 5 times the weight and volume of the original drug, break the wall for 1 to 20 minutes, filter, and centrifuge the filtrate at 2000 to 8000 r / min for 5 to 30 minutes to obtain the first supernatant; then add water and repeat the above method of breaking the wall and centrifuging 1 to 4 times to obtain the second to fifth supernatants, and combine the supernatants of each time;

[0008] After selecting, fresh Rehmannia root is washed 1 to 3 times, cut into pieces or slices while fresh, add 0.5 to 4 times of water, break the wall for 1 to 10 minutes, filter to remove solid residues, and then centrifuge at 2000 to 8000 r / min for 5 to 30 minutes to obtain a supernatant; repeat the wall breaking process of the residue 1 to 4 times to obtain the second to fifth supernatants, and combine the supernatants of each time;

[0009] Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant;

[0010] (2) ultrafiltration of each supernatant obtained in step (1) using a 10000D ultrafiltration membrane to remove macromolecular substances, and collecting each ultrafiltration permeate; then concentrating using a 200D nanofiltration membrane to obtain each nanofiltration concentrate; then freeze-drying each nanofiltration concentrate, collecting each freeze-dried product, and pulverizing to obtain each freeze-dried powder;

[0011] (3) Wash and cut the earthworm medicinal material into sections, freeze-dry, first grind into coarse powder, pass through an 80-100 mesh sieve, and then ultrafine grind and pass through a 150-300 mesh sieve to obtain earthworm ultrafine powder;

[0012] (4) The freeze-dried powders obtained in step (2) and the superfine earthworm powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure. The composition is stored at -20°C for later use and filled into capsules, with 0.5 g per capsule. The sterilization method includes but is not limited to ultra-high pressure sterilization, pasteurization, radiation sterilization, gas sterilization, filtration sterilization, etc.

[0013] The application of the blood pressure lowering Chinese medicine composition in the preparation of blood pressure lowering drugs.

[0014] The blood pressure lowering Chinese medicine composition is further added with pharmaceutically acceptable excipients to prepare blood pressure lowering drugs in different Chinese medicine dosage forms.

[0015] The traditional Chinese medicine dosage forms are granules, tablets and capsules.

[0016] The application of the blood pressure lowering Chinese medicinal composition in the preparation of drugs for preventing, alleviating and treating hypertension.

[0017] The Chinese medicine composition of the present invention plays a synergistic role according to the primary and secondary relationship of monarch, minister, assistant and envoy, has the effects of clearing away heat, calming the liver, promoting blood circulation and promoting diuresis, is effectively used for treating hypertension and reducing complications, and long-term use of the Chinese medicine composition of the present invention can effectively control blood pressure and keep it within a normal range. At the same time, the drug composition and preparation method with blood pressure lowering effect of the present invention have simple process, convenient operation, safety and environmental protection, can retain the active ingredients in the Chinese medicine to the greatest extent, ensure the efficacy of the medicine, and have no toxic side effects when taken for a long time, have good practical clinical application value and development and application prospects, and have huge economic and social benefits. DETAILED DESCRIPTION

[0018] The specific implementation modes of the present invention are described in detail below in combination with embodiments and specific situations.

[0019] Example 1

[0020] The invention discloses a method for preparing a Chinese medicine composition for lowering blood pressure. The Chinese medicine composition is composed of the following raw materials in parts by weight: 65 parts of fresh plantain, 65 parts of fresh motherwort, 65 parts of fresh siegetable herb, 50 parts of fresh red peony root, 65 parts of fresh selfheal, 65 parts of fresh polygonatum, 50 parts of fresh rehmannia root and 4 parts of earthworm. The preparation method is as follows:

[0021] (1) The fresh plantain is selected and washed twice, cut into segments while fresh, and water twice the weight volume of the original drug is added, the cell wall is broken for 5 minutes, filtered, and the filtrate is centrifuged at 4000r / min for 20 minutes to obtain the first supernatant; then 4 times the amount of water is added and the cell wall is broken and centrifuged twice according to the above method to obtain the second and third supernatants, and the supernatants of each time are combined;

[0022] Fresh red peony root is selected and washed twice, cut into sections or 2-4 mm thick slices while fresh, add water twice the weight volume of the original drug, break the wall for 8 minutes, filter, and centrifuge the filtrate at 4000r / min for 20 minutes to obtain the first supernatant; then add 4 times the amount of water and repeat the above method for breaking the wall and centrifugation twice to obtain the second to third supernatants, and combine the supernatants of each time;

[0023] Fresh Rehmannia root was selected and washed twice, cut into pieces or 2-4 mm thick slices while fresh, added with water of 1 times the weight of the original drug, broken for 2.5 minutes, filtered, and the filtrate was centrifuged at 4000r / min for 20 minutes to obtain the first supernatant; then 3 times the amount of water was added and the wall was broken and centrifuged twice according to the above method to obtain the second and third supernatants, and the supernatants of each time were combined;

[0024] Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant;

[0025] (2) ultrafiltration of each supernatant obtained in step (1) using a 10000D ultrafiltration membrane to remove macromolecular substances, and collecting each ultrafiltration permeate; then concentrating using a 200D nanofiltration membrane to obtain each nanofiltration concentrate; then freeze-drying each nanofiltration concentrate, collecting each freeze-dried product, and pulverizing to obtain each freeze-dried powder;

[0026] (3) Wash and cut the earthworm medicinal material into sections, freeze-dry, first grind into coarse powder, pass through a 100-mesh sieve, and then ultrafine grind and pass through a 300-mesh sieve to obtain earthworm ultrafine powder;

[0027] (4) The freeze-dried powders obtained in step (2) and the superfine earthworm powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure.

[0028] Example 2

[0029] The invention discloses a method for preparing a Chinese medicine composition for lowering blood pressure. The Chinese medicine composition is composed of the following raw materials in parts by weight: 100 parts of fresh plantain, 100 parts of fresh motherwort, 100 parts of fresh siegetable herb, 70 parts of fresh red peony root, 100 parts of fresh selfheal, 100 parts of fresh polygonatum, 30 parts of fresh rehmannia root and 5 parts of earthworm. The preparation method is as follows:

[0030] (1) The fresh plantain is selected and washed twice, cut into segments while fresh, and water 4 times the weight volume of the original drug is added to break the wall for 5 minutes, filtered, and the filtrate is centrifuged at 6000r / min for 15 minutes to obtain a first supernatant; then water is added and the wall is broken and centrifuged again according to the above method to obtain a second supernatant, and the supernatants of each time are combined;

[0031] Fresh red peony root was selected and washed twice, cut into sections while fresh, added with water 4 times the weight and volume of the original drug, broken for 10 minutes, filtered, and the filtrate was centrifuged at 6000r / min for 15 minutes to obtain the first supernatant; then water was added and the wall was broken and centrifuged again according to the above method to obtain the second supernatant, and the supernatants of each time were combined;

[0032] Fresh Rehmannia root was selected and washed twice, cut into pieces while fresh, added with water 3 times the weight of the original drug, broken for 5 minutes, filtered, and the filtrate was centrifuged at 6000r / min for 15 minutes to obtain the first supernatant; then water was added and the wall was broken and centrifuged again according to the above method to obtain the second supernatant, and the supernatants of each time were combined;

[0033] Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant;

[0034] (2) ultrafiltration of each supernatant obtained in step (1) using a 10000D ultrafiltration membrane to remove macromolecular substances, and collecting each ultrafiltration permeate; then concentrating using a 200D nanofiltration membrane to obtain each nanofiltration concentrate; then freeze-drying each nanofiltration concentrate, collecting each freeze-dried product, and pulverizing to obtain each freeze-dried powder;

[0035] (3) Wash and cut the earthworm medicinal material into sections, freeze-dry, first grind into coarse powder, pass through a 100-mesh sieve, and then ultrafine grind and pass through a 220-mesh sieve to obtain earthworm ultrafine powder;

[0036] (4) The freeze-dried powders obtained in step (2) and the superfine earthworm powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure.

[0037] Example 3

[0038] The invention discloses a method for preparing a Chinese medicine composition for lowering blood pressure. The Chinese medicine composition is composed of the following raw materials in parts by weight: 30 parts of fresh plantain, 30 parts of fresh motherwort, 30 parts of fresh siegetable herb, 30 parts of fresh red peony root, 30 parts of fresh selfheal, 30 parts of fresh polygonatum, 30 parts of fresh rehmannia root and 2 parts of earthworm. The preparation method is as follows:

[0039] (1) The fresh plantain is selected and washed once, cut into segments while fresh, and water 5 times the weight volume of the original drug is added, the wall is broken for 10 minutes, filtered, and the filtrate is centrifuged at 6000 r / min for 30 minutes to obtain a supernatant;

[0040] Fresh red peony root and scutellaria baicalensis were selected and washed once, cut into 2-4 mm thick slices while fresh, added with water 5 times the weight volume of the original drug, broken the wall for 20 minutes, filtered, and the filtrate was centrifuged at 6000r / min for 30 minutes to obtain the supernatant;

[0041] Fresh Rehmannia root was selected and washed once, cut into 2-4 mm thick slices while fresh, added with water 4 times the weight and volume of the original drug, broken for 10 minutes, filtered, and the filtrate was centrifuged at 6000r / min for 30 minutes to obtain the supernatant;

[0042] Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant;

[0043] (2) ultrafiltration of each supernatant obtained in step (1) using a 10000D ultrafiltration membrane to remove macromolecular substances, and collecting each ultrafiltration permeate; then concentrating using a 200D nanofiltration membrane to obtain each nanofiltration concentrate; then freeze-drying each nanofiltration concentrate, collecting each freeze-dried product, and pulverizing to obtain each freeze-dried powder;

[0044] (3) Wash and cut the earthworm medicinal material into sections, freeze-dry, first grind into coarse powder, pass through an 80-mesh sieve, and then ultrafine grind and pass through a 150-mesh sieve to obtain earthworm ultrafine powder;

[0045] (4) The freeze-dried powders obtained in step (2) and the superfine earthworm powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure.

[0046] Example 4

[0047] The invention discloses a method for preparing a Chinese medicine composition for lowering blood pressure. The Chinese medicine composition is composed of the following raw materials in parts by weight: 80 parts of fresh plantain, 50 parts of fresh motherwort, 80 parts of fresh siegetable herb, 40 parts of fresh red peony root, 80 parts of fresh selfheal, 50 parts of fresh polygonatum, 60 parts of fresh rehmannia root and 3 parts of earthworm. The preparation method is as follows:

[0048] (1) The fresh plantain is selected and washed twice, cut into segments while fresh, and water of 1 times the weight volume of the original drug is added, the cell wall is broken for 5 minutes, filtered, and the filtrate is centrifuged at 2000 r / min for 30 minutes to obtain a first supernatant; then water of 3 times the weight volume of the original drug is added, the cell wall is broken for 2.5 minutes, filtered, and the filtrate is centrifuged at 5000 r / min for 15 minutes to obtain a second supernatant, and water is added according to the above method and the cell wall is broken and centrifuged twice to obtain the third to fourth supernatants, and the supernatants of each time are combined;

[0049] After selecting, wash the fresh red peony root for 1 to 3 times, cut into sections or slices while fresh, add water with a volume of 1 times the weight of the original drug, break the wall for 10 minutes, filter, and centrifuge the filtrate at 2000r / min for 30 minutes to obtain the first supernatant; then add water with a volume of 3 times the weight of the original drug, break the wall for 5 minutes, filter, and centrifuge the filtrate at 5000r / min for 15 minutes to obtain the second supernatant, add water and repeat the wall breaking and centrifugation 2 times according to the above method to obtain the 3rd to 4th supernatant, and combine the supernatants of each time;

[0050] Fresh Rehmannia root was selected and washed twice, cut into sections while fresh, added with water 0.5 times the weight volume of the original drug, broken for 5 minutes, filtered, and the filtrate was centrifuged at 2000r / min for 30 minutes to obtain the first supernatant; then added with water 3 times the weight volume of the original drug, broken for 2.5 minutes, filtered, and the filtrate was centrifuged at 5000r / min for 15 minutes to obtain the second supernatant, and then added with water and repeated the wall breaking and centrifugation twice according to the above method to obtain the third to fourth supernatants, and the supernatants of each time were combined;

[0051] Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant;

[0052] (2) ultrafiltration of each supernatant obtained in step (1) using a 10000D ultrafiltration membrane to remove macromolecular substances, and collecting each ultrafiltration permeate; then concentrating using a 200D nanofiltration membrane to obtain each nanofiltration concentrate; then freeze-drying each nanofiltration concentrate, collecting each freeze-dried product, and pulverizing to obtain each freeze-dried powder;

[0053] (3) Wash and cut the earthworm medicinal material into sections, freeze-dry, first grind into coarse powder, pass through a 100-mesh sieve, and then ultrafine grind and pass through a 280-mesh sieve to obtain earthworm ultrafine powder;

[0054] (4) The freeze-dried powders obtained in step (2) and the superfine earthworm powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure.

[0055] Example 5

[0056] The invention discloses a method for preparing a Chinese medicine composition for lowering blood pressure. The Chinese medicine composition is composed of the following raw materials in parts by weight: 60 parts of fresh plantain, 80 parts of fresh motherwort, 50 parts of fresh siegetable herb, 40 parts of fresh red peony root, 50 parts of fresh selfheal, 80 parts of fresh polygonatum, 40 parts of fresh rehmannia root and 4 parts of earthworm. The preparation method is as follows:

[0057] (1) The fresh plantain is selected and washed three times, cut into segments while fresh, and water twice the weight volume of the original drug is added to break the wall for 3 minutes, filtered, and the filtrate is centrifuged at 8000r / min for 5 minutes to obtain the first supernatant; then water is added and the wall is broken and centrifuged four times according to the above method to obtain the second to fifth supernatants, and the supernatants of each time are combined;

[0058] Fresh red peony root was selected and washed 3 times, cut into segments while fresh, added with water twice the weight volume of the original drug, broken for 10 minutes, filtered, and the filtrate was centrifuged at 8000r / min for 5 minutes to obtain the first supernatant; then water was added and the wall was broken and centrifuged 4 times according to the above method to obtain the second to fifth supernatants, and the supernatants of each time were combined;

[0059] Fresh Rehmannia root was selected and washed 3 times, cut into pieces while fresh, added with water twice the weight of the original drug, broken for 5 minutes, filtered, and the filtrate was centrifuged at 8000r / min for 5 minutes to obtain the first supernatant; then water was added and the wall was broken and centrifuged 4 times according to the above method to obtain the second to fifth supernatants, and the supernatants of each time were combined;

[0060] Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant;

[0061] (2) ultrafiltration of each supernatant obtained in step (1) using a 10000D ultrafiltration membrane to remove macromolecular substances, and collecting each ultrafiltration permeate; then concentrating using a 200D nanofiltration membrane to obtain each nanofiltration concentrate; then freeze-drying each nanofiltration concentrate, collecting each freeze-dried product, and pulverizing to obtain each freeze-dried powder;

[0062] (3) Wash and cut the earthworm medicinal material into sections, freeze-dry, first grind into coarse powder, pass through an 80-mesh sieve, and then ultrafine grind and pass through a 180-mesh sieve to obtain earthworm ultrafine powder;

[0063] (4) The freeze-dried powders obtained in step (2) and the superfine earthworm powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure.

[0064] The application of the blood pressure lowering Chinese medicine composition in the preparation of blood pressure lowering drugs.

[0065] The blood pressure lowering Chinese medicine composition is further added with pharmaceutically acceptable excipients to prepare blood pressure lowering drugs in different Chinese medicine dosage forms.

[0066] The traditional Chinese medicine dosage forms are granules, tablets and capsules.

[0067] The application of the blood pressure lowering Chinese medicinal composition in the preparation of drugs for preventing, alleviating and treating hypertension.

[0068] In the above-mentioned Chinese medicine composition, wherein:

[0069] Fresh plantain: sweet in taste, cold in nature. Enters the liver, lung, kidney and small intestine meridians. Clears away heat, promotes urination, eliminates dampness and stops diarrhea, improves eyesight and removes phlegm.

[0070] Fresh motherwort: bitter, slightly cold in nature. Enters the liver, pericardium, and bladder meridians. Promotes blood circulation and regulates menstruation, clears away heat and detoxifies, and promotes diuresis and reduces swelling.

[0071] Fresh Siegesbeckia: bitter, cold in nature. Enters the liver and kidney meridians. Clears away heat and detoxifies, removes rheumatism, benefits joints, unblocks tendons and activates collaterals, calms the mind.

[0072] Fresh red peony root: bitter, sour, slightly cold. Enters the liver and spleen meridians. Nourishes blood and regulates menstruation, restrains yin and stops sweating, softens the liver and relieves pain, and calms liver yang.

[0073] Fresh Polygonatum: sweet in taste, neutral in nature. Enters the spleen, lung and kidney meridians. Replenishes qi and nourishes yin, strengthens the spleen, moistens the lungs and benefits the kidneys.

[0074] Fresh Prunella Vulgaris: bitter and pungent, cold in nature, enters the liver and gallbladder meridians. Clears the liver and purges fire, improves eyesight, and relieves swelling.

[0075] Fresh Rehmannia root: sweet, bitter, cold in nature, enters the lung, stomach, liver, and large intestine meridians. Clears away heat, cools blood, nourishes yin and produces body fluid.

[0076] Fresh earthworm: salty in taste, cold in nature, enters the liver, spleen, and bladder meridians. Clears away heat and calms wind, dredges meridians, relieves asthma, and promotes urination.

[0077] The compatibility of the Chinese medicine composition of the present invention is perfect and rigorous, and is scientifically and rationally combined according to the compatibility principle of the Chinese medicine monarch, minister, assistant and envoy, and each medicine can play a synergistic role after being combined. Patients with Yin deficiency and Yang hyperactivity syndrome have liver qi depression, which turns into fire for a long time, consumes liver yin, makes yin unable to restrain yang, and liver yang is hyperactive, disturbing the head, and causing symptoms such as headache, dizziness, irritability, etc. Fresh Prunella Vulgaris has the effects of clearing the liver and purging fire, improving eyesight, dispersing nodules and reducing swelling. It can lower blood pressure and improve headaches and dizziness by clearing the liver and dispersing nodules, and calming liver yang; fresh Motherwort can not only promote blood circulation and remove blood stasis, but also promote diuresis to help lower blood pressure. It has a good effect on symptoms such as hypertension, dizziness and limb numbness caused by hyperactivity of liver yang. The two can be used together to clear liver fire, calm liver yang, promote blood circulation and remove blood stasis, promote diuresis and clear the liver, and are the main medicine; fresh Plantain can clear away heat and promote diuresis, discharge excess water and salt from the human body, thereby reducing the volume in blood vessels and achieving the effect of lowering blood pressure. Fresh Siegesbeckia has the effects of clearing away heat and detoxifying, removing rheumatism, which can improve symptoms such as dizziness and headaches in patients with hypertension, and can also help relieve limb numbness caused by hypertension by promoting tendons and activating collaterals. Symptoms such as numbness of the body, the two are ministerial drugs in total, enhancing diuresis and collateral dredging effects; fresh red peony root can suppress liver yang, relieve hypertension caused by hyperactivity of liver yang, and can also improve the systemic symptoms of hypertensive patients through the effects of nourishing blood, regulating menstruation, softening the liver and relieving pain, fresh rehmannia root can nourish yin and moisten dryness, can improve the yin deficiency symptoms of hypertensive patients, and can also clear away heat and cool blood to lower blood pressure, fresh polygonatum sibiricum replenishes qi and nourishes yin, nourishes spleen, lung and kidney, and is used with fresh rehmannia root and fresh red peony root to nourish yin and clear away heat, especially to relieve hypertension caused by yin deficiency and yang hyperactivity, the three are adjuvant drugs in total, can nourish yin and nourish blood, and relieve the related symptoms caused by hypertension; earthworm is good at wandering, can dredge the meridians and activate the collaterals, guide other drugs to directly reach the diseased area, and can also lower blood pressure through diuresis, which is to make drugs. All medicines are used together, with the effects of clearing heat, soothing the liver, activating blood circulation, diuresis, etc., and the effect of lowering blood pressure is comprehensively exerted from multiple ways, and a very good beneficial technical effect is achieved, and the relevant test data are as follows (taking embodiment 1 as an example):

[0078] 1. Source of case selection

[0079] Hypertension is defined as systolic blood pressure >140 mmHg (1 mmHg = 0.133 kPa) and / or diastolic blood pressure >90 mmHg when blood pressure is measured three times on different days without the use of antihypertensive drugs. At the same time, the patient will experience symptoms such as dizziness, headache, palpitations, and insomnia. Patients with the above clinical symptoms will be selected as the source of cases.

[0080] 2. Diagnostic criteria

[0081] 2.1. Western medicine diagnostic criteria

[0082] With reference to the "Chinese Consensus on Hypertension Prevention and Treatment" and the "2018 ESC / ESH Guidelines for the Management of Arterial Hypertension", without the use of antihypertensive drugs, the blood pressure in the clinic was measured three times on different days. According to the level of blood pressure increase, systolic blood pressure>140mmHg (1mmHg=0.133kPa) and (or) diastolic blood pressure>90mmHg, blood pressure was further divided into 1, 2 and 3 levels.

[0083] 2.2 TCM diagnostic criteria

[0084] The differentiation standard of Yin deficiency and Yang hyperactivity syndrome is formulated with reference to the "Guidelines for Clinical Research of New Chinese Medicines (Trial)". Main symptoms: dizziness, headache, irritability, crying, and restlessness; secondary symptoms: palpitations, insomnia, dry mouth, constipation, backache, tinnitus, night sweats, red urine, and fever in the five hearts; tongue and pulse: red tongue with little coating, stringy and fine pulse. If there are 3 or more main symptoms and secondary symptoms, combined with tongue and pulse, the syndrome can be clearly differentiated. The main and secondary symptoms are subdivided into 4 levels according to the degree of none, mild, moderate, and severe, and are scored 0, 2, 4, 6 points and 0, 1, 2, 3 points respectively; normal tongue and pulse are scored 0 points, abnormal ones are scored 1 point, and the higher the score, the more severe the syndrome.

[0085] 2.3 Inclusion and Exclusion Criteria

[0086] 2.3.1 Inclusion criteria

[0087] ① Meet the above-mentioned diagnostic criteria for hypertension; ② Meet the above-mentioned TCM differentiation criteria for Yin deficiency and Yang hyperactivity syndrome; ③ Aged 35 to 85 years old, regardless of gender; ④ Stop taking other similar Chinese medicines and Chinese patent medicines during the clinical observation period; ⑤ Be able to cooperate in filling out relevant questionnaires or scales; ⑥ Give informed consent and voluntarily participate in this study.

[0088] 2.3.2 Exclusion criteria

[0089] ① Patients with heart function grade > Ⅲ of the New York Heart Association; ② Patients with poorly controlled hypertension (blood pressure > 170 / 105 mmHg after taking antihypertensive drugs); ③ Patients with acute myocardial infarction or unstable angina; ④ Patients with severe arrhythmias (such as persistent rapid atrial fibrillation, atrial flutter, frequent ventricular premature beats or ventricular tachycardia); ⑤ Patients with other systemic severe primary diseases; ⑥ Patients with severe mental illness (such as panic, hallucinations or suicidal behavior); ⑦ Patients who are allergic to the test drugs; ⑧ Pregnant or lactating women, and men and women of childbearing age who have planned to get pregnant in the past year.

[0090] 2.4 Elimination conditions

[0091] ①Those who received other treatments during the study and had an impact on the research results; ②All cases completed the entire study without dropout; ③According to the principle of comparability of baseline data between groups, they were divided into a control group and an observation group, with 25 cases in each group. There was no statistically significant difference in the basic data of the two groups of patients (P﹥0.05), see Table 1.

[0092] 3. Treatment options

[0093] A total of 50 cases were observed, including 25 males and 25 females, with an age range of 18 to 75 years.

[0094] The confirmed patients were treated with the composition of the present invention, and a control group was set up during the treatment. 100 cases were randomly divided into 2 groups (experimental group and control group), with 50 people in each group.

[0095] Experimental group: The Chinese medicine composition of the present invention was taken three times a day, 2 g (4 capsules) each time, with warm water.

[0096] Control group: nifedipine tablets, oral, 10-20 mg each time, 3 times a day.

[0097] One month constituted one course of treatment. After one course of treatment, the efficacy of the two groups was observed.

[0098] Measurement: Measure blood pressure on an empty stomach every morning after waking up, and take a rest within half an hour before measurement.

[0099] 4. Criteria for determining the efficacy of hypertension

[0100] Refer to the criteria for determining the efficacy of hypertension in the "Guidelines for Clinical Research of New Chinese Medicines (Trial)".

[0101] Markedly effective: diastolic blood pressure drops to the normal range, with a decrease of >10 mmHg, or diastolic blood pressure does not reach the normal range, but the decrease is >20 mmHg, and the accompanying symptoms basically disappear or are significantly improved;

[0102] Effective: Diastolic blood pressure drops to the normal range, with a decrease of less than 10 mmHg; or diastolic blood pressure does not reach the normal range, but drops by 10-19 mmHg; or systolic blood pressure drops by more than 30 mmHg, accompanied by improvement of symptoms, and treatment needs to be continued;

[0103] Ineffective: The above criteria are not met, and the accompanying symptoms do not improve or even tend to worsen.

[0104] 5. Statistical processing

[0105] 5.1 General Data Comparison

[0106] 5.1.1 Age distribution of subjects

[0107] According to the treatment scheme of the present invention, 100 outpatients diagnosed with the disease were randomly divided into an experimental group and a control group with 50 cases in a ratio of 1:1 using a random number table method: the experimental group had 29 females and 21 males, aged 25 to 70 years old, with a course of disease of 2 to 24 months; the control group had 28 females and 22 males, aged 29 to 70 years old, with a course of disease of 3 to 23 months. There was no significant difference in the general data of the two groups of patients in gender, age, etc. after statistical analysis (P>0.05), and they were comparable, as shown in Table 1.

[0108] 5.1.2 Comparison of blood pressure levels

[0109] Before treatment, there was no significant difference in systolic and diastolic blood pressure between the two groups (P>0.05). After treatment, the systolic and diastolic blood pressure levels of the experimental group were lower than those before treatment (P<0.05), and lower than those of the control group (P>0.05). See Table 2.

[0110] 5.1.3 Comparison of total scores of TCM syndromes

[0111] Before treatment, there was no significant difference in the total score of TCM syndrome between the two groups (P>0.05). After treatment, the total score of TCM syndrome in the experimental group was significantly lower than that before treatment (P<0.01), and lower than that in the control group (P>0.05). See Table 3.

[0112] 5.1.4 Comparison of antihypertensive efficacy between the two groups after intervention

[0113] After intervention, the blood pressure treatment effect of the observation group was better than that of the control group, and the difference between the two groups was statistically significant (P<0.05), as shown in Table 4.

[0114] 5.1.5 Data Analysis Methods

[0115] SPSS 25.0 statistical software was used to process the data. Normally distributed quantitative data were expressed as "mean ± standard deviation", and count data were calculated as percentages. The chi-square test was used to compare the rates between groups. P < 0.05 was considered statistically significant.

[0116] Table 1 Comparison of baseline data between the two groups of patients

[0117]

[0118] Table 2 Comparison of blood pressure levels between the two groups of patients (mmHg)

[0119]

[0120] Note: Compared with the group before treatment, *P<0.05; compared with the control group after treatment, #P<0.05.

[0121] Table 3 Comparison of total TCM syndrome scores between the two groups of patients ( point)

[0122]

[0123] Note: Compared with the group before treatment, **P<0.01; compared with the control group after treatment, ##P<0.01.

[0124] Table 4 Comparison of antihypertensive efficacy between the two groups of patients after treatment

[0125]

[0126] The experimental results show that the total effective rate of lowering blood pressure in the experimental group (pharmaceutical composition of the present invention) is 92%, and the total effective rate of lowering blood pressure in the control group is 76%. At the same time, it can be seen from the experimental results of Tables 2 and 3 that the blood pressure level of patients taking the present invention is lower than that of patients taking the control group, and is within the normal range. This shows that the pharmaceutical composition of the present invention has a good effect of lowering blood pressure, and the therapeutic effect is significantly better than that of the control group.

[0127] Typical cases:

[0128] Case 1: Zhang, female, 59 years old, from XX City, Henan Province. Hypertensive patient, before taking the present invention, had headache, dizziness, emotional restlessness, and accompanied by palpitations, insomnia, dry mouth, constipation and other symptoms. Systolic blood pressure was 155mmHg, diastolic blood pressure was 110mmHg; after taking the present invention for a course of treatment, headache, dizziness, emotional restlessness and complications were significantly improved, systolic blood pressure was 125mmHg, diastolic blood pressure was 85mmHg, and blood pressure was maintained in the normal range after continuous use.

[0129] Case 2: Wang, male, 63 years old, from XX City, Henan Province. Hypertensive patient, before taking the present invention, had headache, irritability, crying, emotional restlessness, and accompanied by palpitations, insomnia, backache, tinnitus, night sweats and other symptoms. Systolic blood pressure was 160mmHg, diastolic blood pressure was 115mmHg; after taking the present invention for a course of treatment, headache, irritability, crying, emotional restlessness, and complications were significantly improved, systolic blood pressure was 120mmHg, diastolic blood pressure was 82mmHg, and blood pressure was maintained within the normal range after continuous use.

[0130] Case 3: Li, male, 48 years old, from XX City, Henan Province. Hypertensive patients, before taking the present invention, had dizziness, headache, irritability, crying, emotional restlessness, and accompanied by palpitations, insomnia, dry mouth, night sweats, red urine, fever in the five hearts, red tongue with less coating and other symptoms. Systolic blood pressure 150mmHg, diastolic blood pressure 105mmHg; after taking the present invention for a course of treatment, dizziness, headache, irritability, crying, emotional restlessness and complications were significantly improved. Systolic blood pressure 124mmHg, diastolic blood pressure 86mmHg, continuous use, blood pressure maintained in the normal range.

[0131] Case 4: Zhu, female, 47 years old, from XXX city, Henan. Hypertensive patient, before taking the present invention, had headache, irritability, crying, emotional restlessness, accompanied by backache, tinnitus, night sweats, dark urine, fever in the five hearts, red tongue with little coating, stringy and thin pulse and other symptoms. Systolic blood pressure 145mmHg, diastolic blood pressure 110mmHg; after taking the present invention for one course of treatment, headache, irritability, crying, emotional restlessness and complications were significantly improved. Systolic blood pressure 114mmHg, diastolic blood pressure 80mmHg, continuous use, blood pressure maintained in the normal range.

[0132] Case 5: Han, male, 35 years old, from XXX city, Henan. Hypertensive patient, before taking the present invention, had symptoms such as dizziness, headache, irritability, crying, restlessness, accompanied by tinnitus, night sweats, fever in the five hearts, red and thin fur, stringy and thin pulse. Systolic blood pressure 160mmHg, diastolic blood pressure 115mmHg; after taking the present invention for one course of treatment, soreness of waist and knees, loss of libido and complications were significantly improved. Systolic blood pressure 120mmHg, diastolic blood pressure 85mmHg, continuous use, blood pressure maintained in the normal range.

[0133] Case 6: Xu, male, 30 years old, from Zhoukou, Henan. Hypertensive patient, before taking the present invention, had symptoms such as dizziness, headache, emotional restlessness accompanied by palpitations, insomnia, night sweats, red tongue with little coating, stringy and thin pulse. Systolic blood pressure 140mmHg, diastolic blood pressure 105mmHg; after taking the present invention for one course of treatment, dizziness, headache, emotional restlessness and complications were significantly improved. Systolic blood pressure 125mmHg, diastolic blood pressure 85mmHg, continuous use, blood pressure maintained in the normal range.

[0134] Case 7: Shang Moumou, female, 51 years old, from XXX City, Henan Province. Hypertensive patients, before taking the present invention, had symptoms such as dizziness, headache, restlessness, palpitations, insomnia, backache, tinnitus, night sweats, red tongue with little coating, and stringy and thin pulse. The systolic blood pressure was 155mmHg and the diastolic blood pressure was 115mmHg; after taking the present invention for one course of treatment, the dizziness, headache, restlessness and complications were significantly improved. The systolic blood pressure was 120mmHg and the diastolic blood pressure was 85mmHg. After continuous use, the blood pressure was maintained in the normal range.

[0135] Case 8: Ren, male, 38 years old, from XX City, Henan Province. Hypertensive patient, before taking the present invention, had headache, irritability, crying, emotional restlessness, accompanied by insomnia, dry mouth, constipation, backache, tinnitus, night sweats, red tongue with little coating, stringy and thin pulse and other symptoms. The systolic blood pressure was 145mmHg, and the diastolic blood pressure was 105mmHg; after taking the present invention for a course of treatment, headache, irritability, crying, emotional restlessness and complications were significantly improved. The systolic blood pressure was 122mmHg, and the diastolic blood pressure was 80mmHg. After continuous use, the blood pressure was maintained in the normal range.

[0136] Case 9: Sun, female, 60 years old, from XX City, Henan Province. Hypertensive patient, before taking the present invention, had symptoms such as dizziness, headache, irritability and crying accompanied by palpitations, insomnia, dry mouth, red tongue with little coating, stringy and thin pulse. The systolic blood pressure was 150 mmHg and the diastolic blood pressure was 115 mmHg. After taking the present invention for one course of treatment, the dizziness, headache, irritability and crying and complications were significantly improved. The systolic blood pressure was 120 mmHg and the diastolic blood pressure was 79 mmHg. After continuous use, the blood pressure was maintained in the normal range.

[0137] Case 10: Zhao Moumou, male, 42 years old, from XX City, Henan Province. Hypertensive patients, before taking the present invention, had symptoms such as dizziness, headache, irritability, crying, restlessness, backache, tinnitus, night sweats, red tongue with little coating, stringy and thin pulse. The systolic blood pressure was 155mmHg and the diastolic blood pressure was 110mmHg. After taking the present invention for one course of treatment, the soreness of the waist and knees, loss of libido, chills and cold limbs and complications were significantly improved. The systolic blood pressure was 120mmHg and the diastolic blood pressure was 75mmHg. After continuous use, the blood pressure was maintained within the normal range.

[0138] While conducting experiments on Example 1, the same experiments were also conducted on other examples, and the same or similar results were obtained, which will not be listed here one by one.

[0139] 6. Conclusion

[0140] In summary, the pharmaceutical composition of the present invention is compatible according to the primary and secondary relationship of monarch, minister, assistant and envoy, and the prescription is scientific and reasonable. Fresh Prunella Vulgaris and fresh Leonurus japonicus can clear liver fire, calm liver yang, promote blood circulation and remove blood stasis, and promote diuresis and clear liver, which are monarch drugs; fresh plantain and fresh Siegesbeckia sibiricum have enhanced heat-clearing effects, and the two are minister drugs, which enhance diuresis and collateral-clearing effects; fresh red peony root can calm liver yang and relieve hypertension caused by hyperactivity of liver yang, fresh Rehmannia root can nourish yin and moisten dryness, can improve the yin deficiency symptoms of hypertensive patients, and can also clear heat and cool blood to lower blood pressure, and fresh Polygonatum odoratum can be used together to nourish qi and nourish yin, improve the merit of nourishing yin and clearing heat, and the three are assistant drugs, which can nourish yin and nourish blood, and relieve the related symptoms caused by hypertension; earthworm is good at wandering, can clear meridians and activate collaterals, and guide other drugs to directly reach the diseased area. All the drugs are used together to clear heat, calm the liver, promote blood circulation, and promote diuresis, and multi-channel comprehensive hypotensive effects are effectively used for hypertension of yin deficiency and yang hyperactivity type, with an effective rate of up to 92%. At the same time, the Chinese medicine composition of the present invention forms a stable fresh medicine preparation process. After wall breaking and pulverization, the effective ingredients of each raw material medicine can be fully released, making full use of them, saving medicinal material resources, having the effect of lowering blood pressure, significantly improving the therapeutic effect, having no toxic side effects, and being able to keep blood pressure within a normal range. Moreover, the Chinese medicine composition of the present invention can be prepared into pharmaceutically permitted dosage forms such as granules, tablets and capsules according to actual needs, having strong practical application value, being conducive to industrial production and development, promotion and application, and having huge economic and social benefits.

Claims

1. A method for preparing a Chinese medicine composition for lowering blood pressure, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 30-100 parts of fresh plantain, 30-100 parts of fresh motherwort, 30-100 parts of fresh siegetable herb, 30-70 parts of fresh red peony root, 30-100 parts of fresh selfheal, 30-100 parts of fresh polygonatum, 30-70 parts of fresh rehmannia root and 2-5 parts of earthworm, and the preparation method is: (1) The fresh plantain is selected and washed 1 to 3 times, cut into segments while fresh, and added with water 1 to 5 times the weight volume of the original drug, where the weight volume refers to the solid in kg and the liquid in L, and the cell wall is broken for 1 to 10 minutes, filtered, and the filtrate is centrifuged at 2000 to 8000 r / min for 5 to 30 minutes to obtain the first supernatant; then water is added and the cell wall is broken and centrifuged 1 to 4 times according to the above method to obtain the second to fifth supernatants, and the supernatants of each time are combined; After selecting, wash the fresh red peony root 1 to 3 times, cut into sections or slices while fresh, add 1 to 5 times the weight and volume of water of the original drug, break the wall for 1 to 20 minutes, filter, and centrifuge the filtrate at 2000 to 8000 r / min for 5 to 30 minutes to obtain the first supernatant; then add water and repeat the above method of breaking the wall and centrifuging 1 to 4 times to obtain the second to fifth supernatants, and combine the supernatants of each time; After selecting, fresh Rehmannia root is washed 1 to 3 times, cut into pieces or slices while fresh, add 0.5 to 4 times of water, break the wall for 1 to 10 minutes, filter to remove solid residues, and then centrifuge at 2000 to 8000 r / min for 5 to 30 minutes to obtain supernatant; repeat the wall breaking process of the residue 1 to 4 times to obtain the second to fifth supernatant, and combine the supernatants of each time; Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant; (2) The supernatants obtained in step (1) are respectively ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates are collected; then, the supernatants are concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; then, the nanofiltration concentrates are freeze-dried, and the freeze-dried products are collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the earthworm into segments, freeze-dry, grind into coarse powder, pass through an 80-100 mesh sieve, and then ultrafine grind and pass through a 150-300 mesh sieve to obtain earthworm ultrafine powder; (4) The freeze-dried powders obtained in step (2) and the earthworm superfine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure.

2. The method for preparing the blood pressure lowering Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 65 parts of fresh plantain, 65 parts of fresh motherwort, 65 parts of fresh siegetable herb, 50 parts of fresh red peony root, 65 parts of fresh selfheal, 65 parts of fresh polygonatum, 50 parts of fresh rehmannia root and 4 parts of earthworm, and the preparation method is: (1) The fresh plantain is selected and washed twice, cut into segments while fresh, and added with water twice the weight volume of the original drug, broken for 5 minutes, filtered, and the filtrate is centrifuged at 4000 r / min for 20 minutes to obtain the first supernatant; then 4 times the amount of water is added and the cell wall is broken and centrifuged twice according to the above method to obtain the second and third supernatants, and the supernatants of each time are combined; Fresh red peony root was selected and washed twice, cut into sections or 2-4 mm thick slices while fresh, added with water twice the weight volume of the original drug, broken for 8 minutes, filtered, and the filtrate was centrifuged at 4000 r / min for 20 minutes to obtain the first supernatant; then 4 times the amount of water was added and the wall was broken and centrifuged twice according to the above method to obtain the second and third supernatants, and the supernatants of each time were combined; Fresh Rehmannia root was selected and washed twice, cut into pieces or 2-4 mm thick slices while fresh, added with water of 1 times the weight of the original drug, broken for 2.5 minutes, filtered, and the filtrate was centrifuged at 4000 r / min for 20 minutes to obtain the first supernatant; then 3 times the amount of water was added and the wall was broken and centrifuged twice according to the above method to obtain the second and third supernatants, and the supernatants of each time were combined; Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant; (2) The supernatants obtained in step (1) are respectively ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates are collected; then, the supernatants are concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; then, the nanofiltration concentrates are freeze-dried, and the freeze-dried products are collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the earthworm into sections, freeze-dry, grind into coarse powder, pass through a 100-mesh sieve, and then ultrafine grind and pass through a 300-mesh sieve to obtain ultrafine earthworm powder; (4) The freeze-dried powders obtained in step (2) and the earthworm superfine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure.

3. The method for preparing the blood pressure lowering Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 100 parts of fresh plantain, 100 parts of fresh motherwort, 100 parts of fresh siegetable herb, 70 parts of fresh red peony root, 100 parts of fresh selfheal, 100 parts of fresh polygonatum, 30 parts of fresh rehmannia root and 5 parts of earthworm, and the preparation method is: (1) The fresh plantain is selected and washed twice, cut into segments while fresh, and water 4 times the weight and volume of the original drug is added to break the wall for 5 minutes, filtered, and the filtrate is centrifuged at 6000 r / min for 15 minutes to obtain the first supernatant; then water is added and the wall is broken and centrifuged again according to the above method to obtain the second supernatant, and the supernatants of each time are combined; Fresh red peony root was selected and washed twice, cut into sections while fresh, and added with water 4 times the weight and volume of the original drug, broken for 10 minutes, filtered, and the filtrate was centrifuged at 6000 r / min for 15 minutes to obtain the first supernatant; then water was added and the wall was broken and centrifuged again according to the above method to obtain the second supernatant, and the supernatants of each time were combined; Fresh Rehmannia root was selected and washed twice, cut into pieces while fresh, and water 3 times the weight of the original drug was added to break the cell wall for 5 minutes, filtered, and the filtrate was centrifuged at 6000 r / min for 15 minutes to obtain the first supernatant; then water was added and the cell wall was broken and centrifuged again according to the above method to obtain the second supernatant, and the supernatants of each time were combined; Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant; (2) The supernatants obtained in step (1) are respectively ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates are collected; then, the supernatants are concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; then, the nanofiltration concentrates are freeze-dried, and the freeze-dried products are collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the earthworm into sections, freeze-dry, grind into coarse powder, pass through a 100-mesh sieve, and then ultrafine grind and pass through a 220-mesh sieve to obtain ultrafine earthworm powder; (4) The freeze-dried powders obtained in step (2) and the earthworm superfine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure.

4. The method for preparing the blood pressure lowering Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 30 parts of fresh plantain, 30 parts of fresh motherwort, 30 parts of fresh siegetable herb, 30 parts of fresh red peony root, 30 parts of fresh selfheal, 30 parts of fresh polygonatum, 30 parts of fresh rehmannia root and 2 parts of earthworm, and the preparation method is: (1) The fresh plantain is selected and washed once, cut into segments while fresh, and water 5 times the weight volume of the original drug is added to break the wall for 10 minutes, filtered, and the filtrate is centrifuged at 6000 r / min for 30 minutes to obtain a supernatant; Fresh red peony root and scutellaria baicalensis were selected and washed once, cut into 2-4 mm thick slices while fresh, added with water 5 times the weight volume of the original drug, broken the wall for 20 minutes, filtered, and the filtrate was centrifuged at 6000 r / min for 30 minutes to obtain the supernatant; Fresh Rehmannia root was selected and washed once, cut into 2-4 mm thick slices while fresh, added with water 4 times the weight and volume of the original drug, broken for 10 minutes, filtered, and the filtrate was centrifuged at 6000 r / min for 30 minutes to obtain the supernatant; Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant; (2) The supernatants obtained in step (1) are respectively ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates are collected; then, the supernatants are concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; then, the nanofiltration concentrates are freeze-dried, and the freeze-dried products are collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the earthworm medicinal material into sections, freeze-dry it, grind it into coarse powder, pass it through an 80-mesh sieve, and then ultrafine grind it and pass it through a 150-mesh sieve to obtain ultrafine earthworm powder; (4) The freeze-dried powders obtained in step (2) and the earthworm superfine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure.

5. The method for preparing the blood pressure lowering Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 80 parts of fresh plantain, 50 parts of fresh motherwort, 80 parts of fresh siegetable herb, 40 parts of fresh red peony root, 80 parts of fresh selfheal, 50 parts of fresh polygonatum, 60 parts of fresh rehmannia root and 3 parts of earthworm. The preparation method is: (1) The fresh plantain is selected and washed twice, cut into segments while fresh, and water of 1 times the weight volume of the original drug is added, the cell wall is broken for 5 minutes, filtered, and the filtrate is centrifuged at 2000 r / min for 30 minutes to obtain the first supernatant; then water of 3 times the weight volume of the original drug is added, the cell wall is broken for 2.5 minutes, filtered, and the filtrate is centrifuged at 5000 r / min for 15 minutes to obtain the second supernatant, and water is added again according to the above method to repeat the cell wall breaking and centrifugation twice to obtain the third and fourth supernatants, and the supernatants of each time are combined; After selecting, wash the fresh red peony root 1 to 3 times, cut into sections or slices while fresh, add water with a volume of 1 times the weight of the original drug, break the wall for 10 minutes, filter, and centrifuge the filtrate at 2000 r / min for 30 minutes to obtain the first supernatant; then add water with a volume of 3 times the weight of the original drug, break the wall for 5 minutes, filter, and centrifuge the filtrate at 5000 r / min for 15 minutes to obtain the second supernatant, and then add water and repeat the wall breaking and centrifugation twice according to the above method to obtain the third to fourth supernatants, and combine the supernatants of each time; Fresh Rehmannia root was selected and washed twice, cut into segments while fresh, added with water 0.5 times the weight volume of the original drug, broken for 5 minutes, filtered, and the filtrate was centrifuged at 2000 r / min for 30 minutes to obtain the first supernatant; then added with water 3 times the weight volume of the original drug, broken for 2.5 minutes, filtered, and the filtrate was centrifuged at 5000 r / min for 15 minutes to obtain the second supernatant, and then added water and repeated the wall breaking and centrifugation twice according to the above method to obtain the 3rd to 4th supernatants, and the supernatants of each time were combined; Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant; (2) The supernatants obtained in step (1) are respectively ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates are collected; then, the supernatants are concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; then, the nanofiltration concentrates are freeze-dried, and the freeze-dried products are collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the earthworm into sections, freeze-dry, grind into coarse powder, pass through a 100-mesh sieve, and then ultrafine grind and pass through a 280-mesh sieve to obtain ultrafine earthworm powder; (4) The freeze-dried powders obtained in step (2) and the earthworm superfine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure.

6. The method for preparing the blood pressure lowering Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 60 parts of fresh plantain, 80 parts of fresh motherwort, 50 parts of fresh siegetable herb, 40 parts of fresh red peony root, 50 parts of fresh selfheal, 80 parts of fresh polygonatum, 40 parts of fresh rehmannia root and 4 parts of earthworm. The preparation method is: (1) The fresh plantain is selected and washed three times, cut into segments while fresh, and added with water twice the weight volume of the original drug, broken for 3 minutes, filtered, and the filtrate is centrifuged at 8000 r / min for 5 minutes to obtain the first supernatant; then water is added and the cell wall is broken and centrifuged four times according to the above method to obtain the second to fifth supernatants, and the supernatants of each time are combined; Fresh red peony root was selected and washed 3 times, cut into segments while fresh, added with water twice the weight of the original drug, broken for 10 minutes, filtered, and the filtrate was centrifuged at 8000 r / min for 5 minutes to obtain the first supernatant; then water was added and the wall was broken and centrifuged 4 times according to the above method to obtain the second to fifth supernatants, and the supernatants of each time were combined; Fresh Rehmannia root was selected and washed 3 times, cut into pieces while fresh, and water twice the weight of the original drug was added to break the wall for 5 minutes, filtered, and the filtrate was centrifuged at 8000 r / min for 5 minutes to obtain the first supernatant; then water was added and the wall was broken and centrifuged 4 times according to the above method to obtain the second to fifth supernatants, and the supernatants of each time were combined; Fresh motherwort, fresh siegetable herb and fresh selfheal are prepared into corresponding supernatants according to the preparation method of fresh plantain supernatant; fresh polygonatum is prepared into corresponding supernatants according to the preparation method of fresh rehmannia supernatant; (2) The supernatants obtained in step (1) are respectively ultrafiltered using a 10000D ultrafiltration membrane to remove macromolecular substances, and the ultrafiltration permeates are collected; then, the supernatants are concentrated using a 200D nanofiltration membrane to obtain nanofiltration concentrates; then, the nanofiltration concentrates are freeze-dried, and the freeze-dried products are collected and pulverized to obtain freeze-dried powders; (3) Wash and cut the earthworm medicinal material into sections, freeze-dry it, grind it into coarse powder, pass it through an 80-mesh sieve, and then ultrafine grind it and pass it through a 180-mesh sieve to obtain ultrafine earthworm powder; (4) The freeze-dried powders obtained in step (2) and the earthworm superfine powder obtained in step (3) are uniformly mixed, vacuum-packed, and sterilized to obtain a Chinese medicine composition for lowering blood pressure.

7. Use of the blood pressure lowering Chinese medicinal composition prepared by the method according to any one of claims 1 to 6 in the preparation of blood pressure lowering drugs.

8. Use of the blood pressure lowering Chinese medicine composition prepared by the method according to claim 7 in the preparation of blood pressure lowering drugs, characterized in that: The medicine is a traditional Chinese medicine composition for lowering blood pressure, which is added with pharmaceutically acceptable auxiliary materials to prepare granules, tablets or capsules.

9. Use of the blood pressure lowering Chinese medicinal composition prepared by the method according to any one of claims 1 to 6 in preparing drugs for preventing, alleviating and treating hypertension.

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