Sample adding needle cleaning device, sample adding needle cleaning system with same and cleaning method

Abstract

The invention relates to a sample needle cleaning device, a sample adding needle cleaning system with the same and a cleaning method. The sampling needle cleaning device comprises a first pipe body, a second pipe body and a third pipe body which are sequentially communicated, a cleaning channel is formed in the second pipe body and used for containing a to-be-cleaned sampling needle, and the second pipe body is provided with a plurality of ultrasonic generation modules. And each ultrasonic generation module can generate ultrasonic waves and superpose the ultrasonic waves in the cleaning channel to form an ultrasonic sound field. The sampling needle cleaning device is provided with a plurality of ultrasonic generation modules, has the advantages of turbulent flow cleaning and ultrasonic cleaning at the same time, and prevents damage to the sampling needle and improves the cleaning effect while achieving miniaturization of the device.

Description

Technical Field

[0001] The invention relates to the field of liquid cleaning, and in particular to a sample adding needle cleaning device, a sample adding needle cleaning system having the same, and a cleaning method. Background Art

[0002] In the fields of life science research, in vitro diagnostics, drug development, and chemical analysis, automated sample loading systems have gradually replaced traditional manual sample loading methods and become a very important tool, greatly improving experimental efficiency and accuracy, and reducing human errors and operational risks.

[0003] The sample needle is one of the core components of the automated sample injection system and plays a vital role in this process. However, due to the frequent contact between the sample needle and various reagents and samples, it is easy to be contaminated, thus affecting the accuracy and reliability of the experimental results. If the sample needle is not thoroughly cleaned, cross contamination between different samples will inevitably occur, which can easily lead to false positive results. Therefore, the cleaning of the sample needle has become an important link that cannot be ignored.

[0004] Existing cleaning devices for sample needles often use high-pressure turbulent cleaning or ultrasonic cleaning. Although turbulent cleaning causes less damage to the sample needle, it takes a long time to clean and it is difficult to ensure the cleaning effect of difficult-to-remove contaminants such as fibrin. In addition, in order to ensure the water pressure in the pipeline, the flow channel of the needle washing cup is thinner, which increases the precision requirements for inserting the sample needle into the needle washing cup, and a special cleaning fluid is also required.

[0005] Although ultrasonic cleaning does not require high requirements on the shape of the cleaning device, and can complete cleaning in a short time under normal water flow, it can also have a good cleaning effect on difficult-to-remove pollutants such as fibrin. However, existing ultrasonic cleaning devices are all single-vibrator excitation, requiring a larger-sized vibrator to provide cleaning energy, and the internal sound field in the cleaning channel chamber is an uneven field, resulting in a generally large device size and uneven cleaning. Summary of the invention

[0006] In view of this, the present invention provides a sample needle cleaning device, a sample needle cleaning system having the same, and a cleaning method, so as to solve or at least alleviate one or more of the above-mentioned problems and other problems existing in the prior art.

[0007] In order to achieve the above-mentioned object, the first aspect of the present invention provides a sample needle cleaning device, the sample needle cleaning device comprises a first tube body, a second tube body and a third tube body which are connected in sequence, the interiors of the first tube body, the second tube body and the third tube body are connected in sequence to form a cleaning channel, The second tube body is provided with a plurality of ultrasonic generating modules, each of which can generate ultrasonic waves respectively and superimpose them in the cleaning channel to form an ultrasonic sound field.

[0008] In the aforementioned sample needle cleaning device, optionally, both ends of the second tube body are provided with the ultrasonic generating modules, and the ultrasonic generating modules are used to provide ultrasonic sound fields to the corresponding areas of the second tube body of the cleaning channel from both ends respectively.

[0009] In the aforementioned sample needle cleaning device, optionally, the first tube body, the second tube body and the third tube body of the sample needle cleaning device are straight tubes that are connected in one piece.

[0010] In the aforementioned sample injection needle cleaning device, optionally, the first tube body and the second tube body, as well as the second tube body and the third tube body are respectively connected by connecting screws, and the connecting screws have an internal through hole, and the internal through hole is connected to the interior of the first tube body, the second tube body, and the third tube body to jointly form the cleaning channel.

[0011] In the aforementioned sample needle cleaning device, optionally, the ultrasonic generating module includes a piezoelectric ceramic and an electrode sheet connected to the piezoelectric ceramic, the piezoelectric ceramic is in the shape of a ring, and the outer diameter of the piezoelectric ceramic is the same as the outer diameter of the second tube body, and the electrode sheet is protruding from the outer periphery of the piezoelectric ceramic.

[0012] In the sample needle cleaning device as described above, optionally, the middle part of the connecting screw passes through the annular hole of the piezoelectric ceramic of the ultrasonic generating module, and the tube body connected to the two ends of the connecting screw presses the piezoelectric ceramic from both ends of the piezoelectric ceramic by cooperating with the connecting screw thread.

[0013] In the aforementioned sample needle cleaning device, optionally, the sample needle cleaning device is provided with a plurality of the second tube bodies, the plurality of the second tube bodies are interconnected to expand the cleaning channel, and the ultrasonic generating modules are provided at both ends of each of the second tube bodies.

[0014] In order to achieve the aforementioned object, the second aspect of the present invention provides a sample needle cleaning system, the sample needle cleaning system comprising the sample needle cleaning device as described above, a hydraulic pump, a cleaning liquid barrel, a vacuum pump and a waste liquid barrel; The first tube body of the sample needle cleaning device is connected to the cleaning liquid barrel through the hydraulic pump, the third tube body is connected to the waste liquid barrel through the vacuum pump, and the ultrasonic generating module located in the second tube body is connected to different ultrasonic excitation signals respectively.

[0015] In order to achieve the aforementioned object, the third aspect of the present invention provides a method for cleaning a sample needle, the method adopts the aforementioned sample needle cleaning system, and the method steps are as follows: Step A: placing the sample needle to be cleaned into the cleaning channel of the second tube body of the sample needle cleaning device; Step B: starting the vacuum pump to make the cleaning channel formed inside the first tube body, the second tube body and the third tube body of the sample needle cleaning device have a vacuum degree; At the same time, the hydraulic pump is operated to draw the cleaning fluid from the cleaning fluid barrel and enter the cleaning channel through the first tube body, and the pressure of the hydraulic pump and the vacuum pump are adjusted to control the flow rate of the cleaning fluid, so that the cleaning fluid forms turbulence in the cleaning channel to clean the sampling needle.

[0016] In the cleaning method as described above, optionally, the method further comprises the following steps: Step C: respectively stimulating the ultrasonic generating modules to generate ultrasonic waves with phase differences respectively, and the ultrasonic waves are superimposed in the cleaning channel to form an ultrasonic sound field to achieve ultrasonic cleaning of the sample adding needle.

[0017] The present invention provides a sample needle cleaning device, which comprises a first tube body, a second tube body and a third tube body which are connected in sequence, wherein a cleaning channel is provided inside the second tube body, and the cleaning channel is used to place the sample needle to be cleaned. The sample needle cleaning device can introduce a high-pressure cleaning liquid from the first tube body and form turbulence in the cleaning channel to clean the sample needle.

[0018] The second tube body is also provided with a plurality of ultrasonic generating modules, which can respectively generate ultrasonic waves with phase differences, and superimpose in the cleaning channel in the second tube body to form a uniform ultrasonic sound field with appropriate intensity, so as to vibrate the cleaning liquid in the cleaning channel to form supercavitation, and ultrasonic cleaning can be performed on the sample needle on the basis of turbulent cleaning. In this way, the sample needle cleaning device of the present invention has the advantages of turbulent and ultrasonic cleaning at the same time, and can prevent damage to the sample needle while ensuring the cleaning strength.

[0019] Furthermore, the present invention also provides a sample needle cleaning system, which includes the sample needle cleaning device, a hydraulic pump, a cleaning liquid barrel, a vacuum pump and a waste liquid barrel as described above, wherein the first tube body of the sample needle cleaning device is connected to the cleaning liquid barrel through the hydraulic pump, the third tube body is connected to the waste liquid barrel through the vacuum pump, and the plurality of ultrasonic generating modules located in the second tube body are respectively connected to different ultrasonic excitation signals. The sample needle cleaning system has various features of the aforementioned sample needle cleaning device, and thus also has its corresponding advantages.

[0020] Furthermore, the present invention also provides a method for cleaning a sample needle. The method adopts the sample needle cleaning system as described above and can achieve turbulent cleaning and turbulent combined with ultrasonic cleaning. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The disclosure of the present invention will become more apparent with reference to the accompanying drawings. It should be understood that these drawings are only for illustrative purposes and are not intended to limit the scope of protection of the present invention.

[0022] Figure 1 It is a three-dimensional schematic diagram of an embodiment of the sample needle cleaning device of the present invention.

[0023] Figure 2 for Figure 1 A schematic diagram of an exploded view of an embodiment of a sample needle cleaning device.

[0024] Figure 3 for Figure 1 A cross-sectional schematic diagram of an embodiment of a sample needle cleaning device.

[0025] Figure 4 for Figure 3 A partial enlarged view of an embodiment of a sample needle cleaning device is shown, wherein the first connecting screw is shown.

[0026] Figure 5 It is a schematic diagram of an embodiment of the sample needle cleaning system of the present invention.

[0027] Figure 6 This is a diagram showing the working principle of ultrasonic cleaning of the sample adding needle cleaning system of the present invention.

[0028] Figure 7 It is a three-dimensional schematic diagram of another embodiment of the sample needle cleaning device of the present invention.

[0029] Figure numerals: 1-first tube body; 11-first tube body; 12-overflow port; 13-liquid inlet; 14-port; 2-first ultrasonic generating module; 21-first piezoelectric ceramic; 22-first electrode sheet; 23-first ultrasonic excitation signal; 24-first ultrasonic wave; 3-second tube body; 31-indicator window; 4-second ultrasonic generating module; 41-second piezoelectric ceramic; 42-second electrode sheet; 43-second ultrasonic excitation signal; 44-second ultrasonic wave; 4 5-third ultrasonic generating module; 5-third tube body; 51-third tube body; 52-liquid outlet; 6-first connecting screw; 61-first connecting screw body; 62-circumferential sealing ring; 63-end sealing ring; 64-liquid inlet; 65-liquid outlet; 66-circumferential groove; 67-end groove; 7-second connecting screw; 8-cleaning channel; 81-hydraulic pump; 82-cleaning liquid barrel; 83-vacuum pump; 84-sample needle cleaning device; 86-waste liquid barrel. DETAILED DESCRIPTION

[0030] With reference to the accompanying drawings and specific embodiments, the structure, composition, characteristics and advantages of the sample needle cleaning device of the present invention and the sample needle cleaning system having the same will be described below in an exemplary manner. However, all descriptions should not be used to form any limitation on the present invention.

[0031] In addition, for any single technical feature described or implied in the embodiments mentioned in this document, or any single technical feature displayed or implied in the accompanying drawings, the present invention still allows for continued arbitrary combination or deletion between these technical features (or their equivalents) without any technical obstacles, and thus it should be considered that these more embodiments according to the present invention are also within the scope of the description of this document.

[0032] It should also be noted that the terms "inside", "outside", etc. indicate orientations or positional relationships based on the orientations or positional relationships of the sample needle cleaning device shown in the accompanying drawings, and are only for the convenience of describing the present disclosure and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present disclosure.

[0033] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features.

[0034] In the description of the present disclosure, “plurality” means at least two, such as two, three or more, etc., unless otherwise clearly and specifically defined.

[0035] Figure 1 It is a three-dimensional schematic diagram of an embodiment of the sample needle cleaning device of the present invention.

[0036] from Figure 1 It can be seen that the sample needle cleaning device 84 of the present invention comprises a first tube body 1, a second tube body 3 and a third tube body 5 which are connected in sequence, and the second tube body 3 has a cleaning channel 8 (such as Figure 3 The first tube body 1 is used to introduce high-pressure cleaning liquid into the cleaning channel of the second tube body 3 to generate turbulence, so as to clean the sample injection needle to be cleaned placed in the cleaning channel 8, and the waste liquid generated by the cleaning is discharged from the third tube body 5.

[0037] The cleaning channel 8 of the second tube body 3 may be provided with a plurality of ultrasonic generating modules, each of which may generate ultrasonic waves respectively, and superimpose to form an ultrasonic sound field in the cleaning channel 8. During cleaning, the ultrasonic sound field may vibrate the cleaning liquid in the cleaning channel 8 to generate supercavitation, and the supercavitation may extend into the tiny pores and complex internal structure of the sample needle to achieve cleaning without dead angles. The superposition of ultrasonic waves generated by a plurality of ultrasonic generating modules may make the formation of the ultrasonic sound field more uniform, and the intensity of the ultrasonic sound field may be adjusted to achieve deep cleaning of the sample needle without damaging the sample needle.

[0038] Optionally, the ultrasonic generating module may also generate an ultrasonic sound field toward the first tube body 1 and / or the third tube body 5 to clean objects in the first tube body 1 and / or the third tube body 5 .

[0039] It can be seen from this that the sample needle cleaning device 84 of the present invention can achieve turbulent cleaning, or turbulent cleaning combined with ultrasonic cleaning. Since ultrasonic cleaning is added to turbulent cleaning, the sample needle can be better cleaned without dead angles, the cleaning efficiency is improved, and the requirements for cleaning liquid are not high, and no special cleaning liquid is required. Therefore, the cleaning channel 8 of the sample needle cleaning device 84 of the present invention does not need to be designed to be smaller to ensure the turbulent water pressure. The shape and size of the cleaning channel 8 can be set according to the specifications of the sample needle, expanding the capacity of the cleaning channel 8, thereby reducing the accuracy requirements for the sample needle to be placed in the cleaning device.

[0040] exist Figure 1 In the embodiment, a first ultrasonic generating module 2 and a second ultrasonic generating module 4 are respectively provided at both ends of the second tube body 3. The first ultrasonic generating module 2 and the second ultrasonic generating module 4 can generate ultrasonic waves, which enter the regional cleaning channel 8 of the second tube body 3 from both ends respectively and are superimposed in the cleaning channel 8 to form an ultrasonic sound field.

[0041] The design of the first ultrasonic generating module 2 and the second ultrasonic generating module 4 at both ends of the second tube body 3 can facilitate the installation of the ultrasonic generating modules. The ultrasonic generating modules are respectively located at both ends of the second tube body 3 to completely cover the inside of the cleaning channel 8, which is convenient for control and achieves the required cleaning effect with a minimum number of ultrasonic generating modules.

[0042] In other embodiments, multiple ultrasonic generating modules may also be installed in other parts of the second tube body 3, such as but not limited to the middle part, the side part, etc., as long as they can be superimposed to generate an ultrasonic sound field in the cleaning channel 8.

[0043] from Figure 1It can also be seen from the embodiment that the first tube body 1, the second tube body 3 and the third tube body 5 of the sample needle cleaning device 84 are straight tubes that are connected as a whole. The straight tube design makes the overall structure of the sample needle cleaning device 84 more simple, small and compact, which is convenient for controlling turbulence and ultrasonic cleaning.

[0044] As shown in the figure, the first tube body 1 is provided with a liquid inlet 13 at the side near its port 14, and the end of the third tube body 5 is provided with a liquid outlet 52, the liquid inlet 13 is used to introduce cleaning liquid from the outside, and the liquid outlet 52 is used to discharge the waste liquid generated by cleaning. The port 14 of the first tube body 1 is used to communicate with external gas, and the external gas can be but not limited to the atmosphere, other gases that are helpful for cleaning, etc., so as to facilitate the circulation of the cleaning liquid in the sample needle cleaning device 84.

[0045] The straight tube of the sample needle cleaning device 84 from the liquid inlet 13 to the liquid outlet 52 is integrally connected, which can prevent the waste liquid generated by cleaning from remaining in the dead zone of the sample needle cleaning device 84, thereby preventing the residual waste liquid from contaminating the sample needle and reducing the difficulty of cleaning the sample needle cleaning device 84. Figure 1 As shown, the first tube body 1 may also be provided with an overflow port 12 on the side near its port. The overflow port 12 is closer to the port of the first tube body 1 than the liquid inlet 13. The overflow port 12 is used to prevent the cleaning liquid from overflowing from the port of the first tube body 1 and causing external pollution.

[0046] It should be noted here that the cleaning liquid can be a special cleaning liquid, or it can be pure water, deionized water, special cleaning liquid for sample injection needles, etc. Different cleaning liquids can be used in combination with the cleaning method.

[0047] Figure 2 for Figure 1 A schematic diagram of an exploded view of an embodiment of a sample needle cleaning device.

[0048] from Figure 2 It can be seen that the sample adding needle cleaning device 84 may further include a connecting screw, which is used for connecting the first tube body 1 and the second tube body 3 , and the second tube body 3 and the third tube body 5 .

[0049] Specifically, the connecting screw can be screwed into the interior of the sample needle cleaning device 84, combined with Figure 1 It can be seen that after the installation is completed, the connecting screw is completely embedded in the first tube body 1, the second tube body 3 and the third tube body 5, and the middle part of the connecting screw can pass through the ultrasonic generating module. The connecting screw has an internal through hole, which is a cleaning channel for the cleaning liquid, that is, the cleaning liquid can flow into the next pipeline through the through hole of the connecting screw.

[0050] The setting of the connecting screw being installed and connected inside the sample needle cleaning device 84 can make the connection between the first tube body 1, the second tube body 3 and the third tube body 5 tighter, making the structure of the sample needle cleaning device 84 compact, thereby facilitating the disassembly and installation of the cleaning channel of the sample needle cleaning device 84.

[0051] exist Figure 2 In the embodiment, the sample needle cleaning device 84 is provided with a first connecting screw 6 and a second connecting screw 7, the first tube body 1, the first ultrasonic generating module 2, and the second tube body 3 are connected by the first connecting screw 6, and the second tube body 3, the second ultrasonic generating module 4 and the third tube body 5 are connected by the second connecting screw 7.

[0052] Specifically, the liquid inlet end 64 of the first connecting screw 6 is threadedly connected to the interior of the first tube body 1, the middle part of the first connecting screw 6 passes through the first ultrasonic generating module 2, and the liquid outlet end 65 of the first connecting screw 6 is connected to the second tube body 3; the connection method of the second connecting screw 7 is the same as that of the first connecting screw 6, which will not be repeated here.

[0053] exist Figure 2 In the embodiment, the outer diameters of both ends of the first connecting screw 6 and the second connecting screw 7 are smaller than the outer diameters of the middle parts.

[0054] In other embodiments, the first tube body 1, the second tube body 3 and the third tube body 5 may be connected by other means, such as but not limited to flange connection, welding, clamping, etc.

[0055] Furthermore, if Figure 2 As shown, the second tube body 3 may be provided with an indication window 31 so that the cleaning condition of the sample adding needle inside the second tube body 3 can be observed from the outside.

[0056] Figure 3 for Figure 1 A cross-sectional schematic diagram of an embodiment of a sample needle cleaning device.

[0057] from Figure 3 It can be seen that the internal structure of the sample needle cleaning device 84 of the present invention is that the internal through holes of the first tube body 1, the second tube body 3, the third tube body 5, and the connecting screws between the tube bodies are connected to form an integrated through cleaning channel 8. The sample needle can be placed in the cleaning channel 8 and the cleaning liquid can flow through it.

[0058] It can be clearly seen from the figure that the cleaning channel 8 is a straight channel without dead zones such as bends, so that the cleaning liquid can pass through and be discharged from the cleaning channel 8 smoothly without cleaning pollution residue. At the same time, the straight channel design of the cleaning channel 8 can easily control the flow rate of the cleaning liquid passing through the cleaning channel 8 to achieve different turbulent cleaning degrees.

[0059] It can also be clearly seen from the figure that the first tube body 1 of the sample adding needle cleaning device 84 includes a first tube body main body 11 , and a liquid inlet 13 and an overflow port 12 are arranged on the side of the first tube body main body 11 .

[0060] As shown in the figure, the ultrasonic generating module of the second tube body 3 includes a piezoelectric ceramic and an electrode sheet connected to the piezoelectric ceramic. Figure 3 The embodiments are described in detail below.

[0061] exist Figure 3 In the embodiment, the two ends of the second tube body 3 are respectively provided with a first ultrasonic generating module 2 and a second ultrasonic generating module 4. The first ultrasonic generating module 2 includes a first piezoelectric ceramic 21 and a first electrode sheet 22. Similarly, the second ultrasonic generating module 4 includes a second piezoelectric ceramic 41 and a second electrode sheet 42. The shape and structure of the second ultrasonic generating module 4 are the same as those of the first ultrasonic generating module 2. Therefore, the first ultrasonic generating module 2 is taken as an example to illustrate the ultrasonic generating module.

[0062] The first electrode sheet 22 of the first ultrasonic wave generating module 2 is connected to the first piezoelectric ceramic 21 . The first electrode sheet 22 is used to transmit an external excitation signal to the first piezoelectric ceramic 21 to excite the first piezoelectric ceramic 21 to generate ultrasonic waves.

[0063] Optionally, combined Figure 2 As shown, the shape of the first piezoelectric ceramic 21 can be a ring, and the outer diameter of the ring is the same as the outer diameter of the second tube 3, so that the sample needle cleaning device 84 is a straight tube with a uniform outer diameter. The middle part of the first connecting screw 6 passes through the ring hole of the first piezoelectric ceramic 21, and the first tube 1 and the second tube 3 connected at both ends of the first connecting screw 6 are screwed together with the first connecting screw 6 to press the first piezoelectric ceramic 21 from both ends of the first piezoelectric ceramic 21, so that when the first piezoelectric ceramic 21 is subjected to an external excitation signal, it can send ultrasonic waves to the first tube 1 and / or the second tube 3 at both ends thereof.

[0064] Furthermore, as shown in the figure, the first electrode sheet 22 is protruded from the outer periphery of the first piezoelectric ceramic 21 to facilitate external connection of ultrasonic excitation signals.

[0065] The coordinated arrangement of the first piezoelectric ceramic 21 and the first electrode sheet 22 of the first ultrasonic generating module 2 makes the first ultrasonic generating module 2 compact and easy to install.

[0066] exist Figure 3In the embodiment of the present invention, the first electrode sheet 22 and the second electrode sheet 42 can be respectively arranged on the same side of the sample needle cleaning device 84 to facilitate connection with an external ultrasonic excitation signal. In other embodiments, the first electrode sheet 22 and the second electrode sheet 42 can also be arranged on different sides according to actual conditions, as long as it is convenient to connect with an external ultrasonic excitation signal.

[0067] It can also be seen from the figure that the third tube body 5 includes a third tube body main body 51 and a liquid outlet 52 , and the liquid outlet 52 is arranged at the end of the third tube body main body 51 .

[0068] It can also be clearly seen from the figure that the first connecting screw 6 and the second connecting screw 7 are completely embedded in the sample needle cleaning device 84 after installation.

[0069] Figure 4 for Figure 3 A partial enlarged view of an embodiment of a sample needle cleaning device is shown, wherein the first connecting screw is shown.

[0070] It can be clearly seen from the figure that the first connecting screw rod 6 includes a connecting first screw rod body 61. Figure 3 It can be seen that both ends of the first connecting screw body 61 are respectively provided with end grooves 67, and the end grooves (67) are used to place end sealing rings 63, and the end sealing rings 63 can prevent the cleaning liquid from leaking at the end connection of the first connecting screw 6.

[0071] Furthermore, circumferential grooves 66 are respectively provided near both ends of the first connecting screw body 61 , and the circumferential grooves 66 are used to place circumferential sealing rings 62 , and the circumferential sealing rings 62 are used to further prevent leakage of cleaning liquid at the end connection of the first connecting screw body 61 .

[0072] It should be noted that the shape, structure and connection method of the second connecting screw 7 are the same as those of the first connecting screw 6, and will not be described in detail here.

[0073] Figure 5 It is a schematic diagram of an embodiment of the sample needle cleaning system of the present invention.

[0074] from Figure 5 It can be seen that the sample needle cleaning system includes a sample needle cleaning device 84 , a hydraulic pump 81 , a cleaning liquid barrel 82 , a vacuum pump 83 and a waste liquid barrel 86 .

[0075] Specifically, the liquid inlet 13 of the first tube body 1 of the sample needle cleaning device 84 is connected to the cleaning liquid barrel 82 through the hydraulic pump 81, and the overflow port 12 of the first tube body 1 is connected to the waste liquid barrel 86, and the liquid outlet 52 of the third tube body 5 is connected to the waste liquid barrel 86 through the vacuum pump 83.

[0076] The first ultrasonic generating module 2 and the second ultrasonic generating module 4 respectively located at two ends of the second tube body 3 are connected to the first ultrasonic excitation signal 23 and the second ultrasonic excitation signal 43 respectively.

[0077] Figure 6 This is a diagram showing the working principle of ultrasonic cleaning of the sample adding needle cleaning system of the present invention.

[0078] Figure 6 The figure shows the first piezoelectric ceramic 21 of the first ultrasonic wave generating module 2 and the second piezoelectric ceramic 41 of the second ultrasonic wave generating module 4 of the sample needle cleaning device 84. It can be seen from the figure that the first ultrasonic wave 24 and the second ultrasonic wave 44 respectively generated by the first piezoelectric ceramic 21 and the second piezoelectric ceramic 41 have a phase difference, and are superimposed on each other during the transmission process in the cleaning channel 8 of the sample needle cleaning device 84. Since ultrasonic waves are directional, the farther away from the sound source, the weaker the sound intensity. Therefore, controlling the superposition between the ultrasonic waves generated by two or more groups of piezoelectric ceramics can make the cleaning channel 8 have a more uniform sound field, that is, the sound pressure distribution of the ultrasonic sound field in the cleaning channel 8 is more uniform.

[0079] The intensity of the ultrasonic sound field can also be adjusted by superimposing the first ultrasonic wave 24 and the second ultrasonic wave 44 with a phase difference, so that the supercavitation generated by the ultrasonic wave in the cleaning liquid in the sample needle cleaning device 84 is more uniform, and its intensity is appropriate to ensure the cleaning intensity without damaging the sample needle.

[0080] The first ultrasonic excitation signal 23 and the second ultrasonic excitation signal 43 may be voltage signals, and the sound field intensity of the ultrasonic wave may be controlled by the voltage amplitude.

[0081] The present invention further provides a method for cleaning a sample needle, which uses the aforementioned sample needle cleaning system. Figure 5 and Figure 6 Describe the needle cleaning method: Step A: Place the sample needle to be cleaned into the cleaning channel 8 of the second tube body 3 of the sample needle cleaning device 84 .

[0082] Step B: Start the vacuum pump 83 to make the cleaning channel 8 formed inside the first tube body 1, the second tube body 3 and the third tube body 5 of the sample adding needle cleaning device 84 have a vacuum degree.

[0083] At the same time, the hydraulic pump 81 is operated to draw the cleaning liquid from the cleaning liquid barrel 82 and enter the cleaning channel 8 through the first tube body 1. The pressure of the hydraulic pump 81 and the vacuum pump 83 can be adjusted to control the flow rate of the cleaning liquid in the cleaning channel 8, so that the cleaning liquid forms turbulence in the cleaning channel 8 to clean the sampling needle, thereby realizing turbulent cleaning.

[0084] Further, turbulent cleaning is combined with ultrasonic cleaning: Step C: The first ultrasonic excitation signal 23 and the second ultrasonic excitation signal 43 are used to respectively excite the first ultrasonic generating module 2 and the second ultrasonic generating module 4, so that they respectively generate the first ultrasonic wave 24 and the second ultrasonic wave 44 with a phase difference.

[0085] The first ultrasonic wave 24 and the second ultrasonic wave 44 are superimposed in the cleaning channel 8 to form an ultrasonic sound field, so that the cleaning liquid generates supercavitation, thereby realizing turbulent flow combined with ultrasonic cleaning of the sample adding needle, ensuring the cleaning strength while preventing damage to the sample adding needle. Figure 7 It is a three-dimensional schematic diagram of another embodiment of the sample needle cleaning device of the present invention.

[0086] It is understandable that the first tube body 1, the second tube body 3 and the third tube body 5 of the sample needle cleaning device 84 of the present invention are connected by a screw (such as Figure 2 The components are connected as shown in the figure, so that these components can be easily disassembled and installed.

[0087] Therefore, according to the situation of the sample needle, for example, the sample needle is long or the sample needle cleaning area requires a larger area, the number of second tube bodies 3 can be increased, so that multiple second tube bodies 3 are interconnected to expand the cleaning channel 8 and expand the cleaning area of ​​the sample needle, and ultrasonic generating modules are provided at both ends of each second tube body 3, so as to further ensure that the ultrasonic sound field in the cleaning channel 8 of each second tube body 3 is uniform and of appropriate intensity.

[0088] exist Figure 7 In the embodiment, the sample needle cleaning device 84 is provided with two second tube bodies 3, the two second tube bodies 3 are in contact with each other, and are respectively connected to the first tube body 1 and the second tube body 3. The two second tube bodies 3 are provided with a first ultrasonic generating module 2 at the connection with the first tube body 1, and a second ultrasonic generating module 4 at the connection with the third tube body 5, and a third ultrasonic generating module 45 is also provided between the two second tube bodies 3, so that the ultrasonic generating modules at both ends of each second tube body 3 can generate ultrasonic waves, and the two second tube bodies 3 are superimposed to form an ultrasonic sound field.

[0089] The technical scope of the present invention is not limited to the contents of the above description. Those skilled in the art can make various deformations and modifications to the above implementation without departing from the technical idea of ​​the present invention, and these deformations and modifications should all fall within the scope of the present invention.

Claims

1. A sample needle cleaning device, characterized in that: The sample needle cleaning device (84) comprises a first tube body (1), a second tube body (3) and a third tube body (5); the interiors of the first tube body (1), the second tube body (3) and the third tube body (5) are connected in sequence to form a cleaning channel (8); the second tube body (3) is provided with a plurality of ultrasonic generating modules (2, 4); each of the ultrasonic generating modules (2, 4) can generate ultrasonic waves respectively and superimpose them in the cleaning channel to form an ultrasonic sound field.

2. The sample needle cleaning device according to claim 1, characterized in that: The ultrasonic generating modules (2, 4) are provided at both ends of the second tube body (3), and the ultrasonic generating modules (2, 4) are used to provide an ultrasonic sound field to the area of ​​the cleaning channel corresponding to the second tube body (3) from both ends respectively.

3. The sample needle cleaning device according to claim 1, characterized in that: The first tube body (1), the second tube body (3) and the third tube body (5) of the sample adding needle cleaning device (84) are straight tubes that are connected to each other as a whole.

4. The sample needle cleaning device according to claim 1, characterized in that: The first tube body (1) and the second tube body (3), as well as the second tube body (3) and the third tube body (5) are connected via connecting screws (6, 7), respectively. The connecting screws (6, 7) have internal through holes, and the internal through holes are connected to the interiors of the first tube body (1), the second tube body (3), and the third tube body (5) to form the cleaning channel.

5. The sample needle cleaning device according to claim 4, characterized in that: The ultrasonic generating module (2, 4) comprises a piezoelectric ceramic (21, 41) and an electrode sheet (22, 42) connected to the piezoelectric ceramic (21, 41); the piezoelectric ceramic (21, 41) is in the shape of a ring, and the outer diameter of the piezoelectric ceramic (21, 41) is the same as the outer diameter of the second tube body (3); the electrode sheet (22, 42) is protruding from the outer periphery of the piezoelectric ceramic (21, 41).

6. The sample needle cleaning device according to claim 5, characterized in that: The middle portion of the connecting screw (6, 7) passes through the annular hole of the piezoelectric ceramic (21, 41) of the ultrasonic generating module, and the tube bodies connected to the two ends of the connecting screw (6, 7) press the piezoelectric ceramic (21, 41) from both ends of the piezoelectric ceramic (21, 41) by cooperating with the thread of the connecting screw.

7. The sample needle cleaning device according to claim 1, characterized in that: The sample needle cleaning device (84) is provided with a plurality of second tube bodies (3), the plurality of second tube bodies (3) are interconnected to extend the cleaning channel (8), and the ultrasonic wave generating modules (2, 4, 45) are provided at both ends of each second tube body (3).

8. A sample needle cleaning system, characterized in that: The sample needle cleaning system comprises a sample needle cleaning device (84) as claimed in any one of claims 1 to 7, a hydraulic pump (81), a cleaning liquid barrel (82), a vacuum pump (83) and a waste liquid barrel (86); The first tube body (1) of the sample needle cleaning device (84) is connected to the cleaning liquid barrel (82) via the hydraulic pump (81), the third tube body (5) is connected to the waste liquid barrel (86) via the vacuum pump (83), and the ultrasonic generating modules (2, 4) located in the second tube body (3) are respectively connected to different ultrasonic excitation signals (23, 43).

9. A method for cleaning a sample needle, characterized in that: The method adopts the sample needle cleaning system as claimed in claim 9, and the method steps are as follows: Step A: placing the sample needle to be cleaned into the cleaning channel (8) of the second tube body (3) of the sample needle cleaning device (84); Step B: starting the vacuum pump (83) so that the cleaning channel (8) formed inside the first tube body (1), the second tube body (3) and the third tube body (5) of the sample needle cleaning device (84) has a vacuum degree; At the same time, the hydraulic pump (81) is operated to draw the cleaning liquid from the cleaning liquid barrel (82) and allow the cleaning liquid to enter the cleaning channel (8) through the first tube body (1), and the pressure of the hydraulic pump (81) and the vacuum pump (83) is adjusted to control the flow rate of the cleaning liquid, so that the cleaning liquid forms a turbulent flow in the cleaning channel (8) to clean the sample injection needle.

10. The cleaning method according to claim 9, characterized in that: The method further comprises the steps of: Step C: respectively stimulating the ultrasonic wave generating modules (2, 4) to respectively generate ultrasonic waves (24, 44) with phase differences, wherein the ultrasonic waves (24, 44) are superimposed in the cleaning channel (8) to form an ultrasonic sound field, so as to achieve ultrasonic cleaning of the sample addition needle.

Images