Wet mixing liquid stabilizing system and application thereof in premature / low birth weight infant formula food

Abstract

The invention relates to a wet mixing feed liquid stabilizing system and application thereof in premature / low birth weight infant formula food, and belongs to the technical field of formula food. In order to solve the problems of easy protein flocculation, poor thermal stability and poor brewing performance in the processing process of formula food for infants with premature birth / low birth weight, the invention provides a wet mixing liquid stabilizing system. The raw materials comprise raw milk, demineralized whey powder, whey protein powder, edible plant blend oil, maltodextrin, a compound vitamin nutritional supplement and a compound mineral nutritional supplement. According to the invention, on the basis of the mineral nutritional supplement in the wet mixed feed liquid with high protein content and high whey protein ratio, the nutritional composition and proportion in the mineral nutritional supplement are optimized and adjusted, so that the wet mixed feed liquid keeps good thermal stability under the key processing procedure of high-temperature sterilization; the problem of processing stability of the formula food for the premature / low-birth-weight infants is solved, and the brewing characteristic of the formula food is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of formula foods, and in particular relates to a wet mix liquid stabilization system and application thereof in formula foods for premature / low birth weight infants. Background Art

[0002] Adequate and balanced nutrition for premature / low birth weight infants is an important material basis for ensuring their quality of life. Formula foods for premature / low birth weight infants for special medical purposes are mainly formula milk powder. To ensure the freshness of the raw materials, fresh milk is usually used for production. The use of wet process or dry-wet composite process can make the nutrients mixed more evenly and ensure the activity of heat-sensitive nutrients.

[0003] Wet mix liquid refers to the mixture obtained by mixing liquid fresh milk raw materials with various nutrients in a liquefied state during the production process of wet process or dry-wet composite process. Special medical purpose premature / low birth weight infant formula has higher requirements for nutrients such as energy, protein, fat, carbohydrates, vitamins and minerals than ordinary infant formula, including increased protein content, a ratio of casein and whey protein closer to breast milk levels, and increased demand for vitamins and minerals. The increase in vitamin content will reduce the overall pH value of the wet mix liquid, which is likely to cause the protein in the wet mix liquid to become more unstable under the dual influence of the lower system pH and the increase in the content of divalent cations such as calcium and magnesium. In the subsequent sterilization, concentration and other heating processes, protein flocculation and decreased thermal stability are likely to occur, which will lead to a large number of small white spots after protein denaturation after the spray-dried product is reconstituted, affecting the reconstitution quality of the product.

[0004] The application document with publication number CN117223848A provides a powdered nutritional composition suitable for premature infants and a preparation method thereof. The method uses ceramic membrane microfiltration to treat skimmed milk technology combined with online fat addition to overcome the denaturation and flocculation problems of high-protein and high-whey protein formulas after heat treatment from the perspective of production process adjustment and optimization, but does not pay attention to the processing thermal stability of the ingredient milk system.

[0005] The application document with publication number CN117137130A provides a whey protein-bean protein co-stabilized complete nutritional special medical purpose formula food emulsion and its preparation method. This method solves the problem of emulsion instability and gelation caused by thermal polymerization when the whey protein emulsion and mineral ions coexist from the perspective of protein raw material adjustment by adding unhydrolyzed bean protein and adjusting the ratio of whey protein to bean protein. However, it restricts the use of protein raw materials and has limitations in product application, and is not suitable for special medical purpose infant formula.

[0006] The application document with publication number CN116406785 A provides a stabilizing system for emulsions of special medical purpose formula foods. The invention improves the stability of the emulsion by adding additional composite aqueous solution emulsifiers, colloids, etc., but the use of food additives in special medical purpose infant formula foods is strictly controlled, and food additives such as colloid stabilizers and acidity regulators cannot be added and used at will. Summary of the invention

[0007] In order to solve the problems of protein flocculation, decreased thermal stability and poor reconstitution performance that are prone to occur during the processing of formula foods for premature / low birth weight infants, the present invention provides a wet mix liquid stabilization system and its application in formula foods for premature / low birth weight infants.

[0008] The technical solution of the present invention:

[0009] A wet mix liquid stabilizing system. 1000 parts by weight of the powdered wet mix liquid stabilizing system comprises raw materials for preparing 1650-3250 parts of raw cow milk, 30-450 parts of desalted whey powder, 20-200 parts of whey protein powder, 60-300 parts of edible vegetable blending oil, 80-350 parts of maltodextrin, 3-15 parts of compound vitamin nutritional supplements and 10-40 parts of compound mineral nutritional supplements. The 1000 parts by weight of the powdered wet mix liquid stabilizing system contains citrate provided by a compound derived from sodium and potassium elements, and the content of the citrate is 2.13-3.77 parts.

[0010] Furthermore, the pH of the wet mix liquid stabilization system is 6.40-7.00.

[0011] Furthermore, the dry matter content of the raw cow's milk is 12%; the whey protein powder is one or more of whey protein powder type 80, whey protein powder containing α-lactalbumin, whey protein powder containing milk fat globule membrane protein or hydrolyzed whey protein powder; the edible vegetable blending oil is one or more of vegetable oil, medium-chain triglycerides or 1,3-dioleyl-2-palmityl triglyceride.

[0012] Furthermore, the components of the compound vitamin nutritional supplement include one or more of retinyl acetate, cholecalciferol, tocopherol acetate, phytonadione, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, hydrocobalamin, niacinamide, folic acid, D-calcium pantothenate, sodium L-ascorbate, biotin, inositol, sulfonic acid, choline and L-carnitine.

[0013] Furthermore, the compound vitamin nutritional supplement contains 0.50-5.00wt% retinyl acetate, 0.60-4.00wt% cholecalciferol, 3.00-22.00wt% dl-α-tocopherol acetate, 0.05-0.60wt% phytonadione, 0.05-0.50wt% thiamine hydrochloride, 0.20-5.00wt% riboflavin, 1.00-8.00wt% pyridoxine hydrochloride, 0-0.10wt% Hydrogen cobalamin, 0.50-6.00wt% nicotinamide, 0.10-0.80wt% folic acid, 0.30-1.80wt% D-calcium pantothenate, 7.00-40.00wt% L-sodium ascorbate, 0.10-1.00wt% D-biotin, 5.00-30.00wt% inositol, 2.00-15.00wt% taurine, 9.00-35.00wt% choline chloride and 0.50-5.00wt% L-carnitine.

[0014] Furthermore, the compound as a source of sodium in the compound mineral nutritional supplement is sodium citrate and / or sodium chloride; the compound as a source of potassium is potassium citrate and / or potassium chloride; the compound mineral nutritional supplement contains 3.00-43.00wt% of sodium citrate and / or potassium citrate, 0-23.00wt% of sodium chloride and 3-46wt% of potassium chloride.

[0015] Furthermore, the composite mineral nutritional supplement also contains 0-3.00wt% copper sulfate, 1.50-12.00wt% magnesium sulfate, 0.50-10.00wt% ferrous sulfate, 0.40-5.50wt% zinc sulfate, 0.05-0.70wt% manganese sulfate, 0.50-3.50wt% potassium iodide, 0.10-1.50wt% sodium selenite, 2.00-35.00wt% calcium carbonate and 5.00-45.00wt% tricalcium phosphate.

[0016] Application of a wet mix liquid stabilization system in formula food for premature / low birth weight infants.

[0017] Furthermore, the preparation method of the powdered semi-finished product / finished product of the premature / low birth weight infant formula food is as follows: all raw materials of the wet mixed liquid stabilization system are mixed by a vacuum mixing system to obtain a wet mixed liquid, wherein the dry matter content of the obtained wet mixed liquid is 15.5-18.5%; the obtained wet mixed liquid is homogenized at a homogenization temperature of 35-65° C. and a homogenization pressure of 140-210 bar, and after homogenization, the wet mixed liquid is cooled to 0-8° C. for standby use; the homogenized wet mixed liquid is sterilized at a sterilization temperature of 85-100° C., and the dry matter content of the concentrated liquid after concentration by an evaporator is 38-45%, and the obtained concentrated liquid is sent to a spray drying tower for spray drying to obtain a powdered semi-finished product / finished product prepared by the wet mixed liquid stabilization system.

[0018] Furthermore, the osmotic pressure of the standard preparation solution of the premature / low birth weight infant formula is less than 300 mOsmol / kg.

[0019] Beneficial effects of the present invention:

[0020] The present invention provides a wet mix liquid stabilization system and its application in premature / low birth weight infant formula food. The present invention is based on a mineral nutritional supplement in a wet mix liquid with a high protein content and a high whey protein ratio, optimizes and adjusts the citrate composition and proportion in the mineral nutritional supplement, and combines the pH of the wet mix liquid to ensure that the osmotic pressure of the final product is suitable for the needs of premature infants. The wet mix liquid maintains good thermal stability under the key processing steps of high-temperature sterilization, solves the problem of processing stability of premature / low birth weight infant formula food, reduces the phenomenon of a large number of white spots after the formula food is prepared after spray drying, and improves the preparation characteristics of the formula food.

[0021] The present invention does not use any additional food additives and is suitable for special medical purpose premature / low birth weight infant formula food produced with high-quality raw cow's milk or other fresh milk as raw materials by wet process / dry-wet composite process (wet part). At the same time, the osmotic pressure of the product is maintained within a reasonable range and does not impose a burden on the intestines of premature infants. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a photograph of the appearance of the wet mixed liquid after the DSI sterilization process in Example 1;

[0023] Figure 2 This is a photograph of the appearance of the wet mixed liquid of Example 2 after the DSI sterilization process;

[0024] Figure 3 This is a photograph of the appearance of the wet mixed liquid of Example 3 after the DSI sterilization process;

[0025] Figure 4 This is a photograph of the appearance of the wet mixed liquid of Example 4 after the DSI sterilization process;

[0026] Figure 5 This is a photograph of the appearance of the wet mixed liquid of Comparative Example 1 after the DSI sterilization process;

[0027] Figure 6 This is a photograph of the appearance of the wet mixed liquid of Comparative Example 2 after the DSI sterilization process;

[0028] Figure 7 This is a photograph of the appearance of the wet mixed liquid of Comparative Example 3 after the DSI sterilization process;

[0029] Figure 8This is a photograph of the appearance of the wet mixed liquid of Comparative Example 4 after the DSI sterilization process;

[0030] Fig. 9 This is a photograph of the appearance of a powdered semi-finished product / finished standard dispensing liquid prepared by the wet mix liquid stabilization system of Example 1;

[0031] Fig.10 This is a photograph of the appearance of the powdered semi-finished / finished standard dispensing liquid prepared by the wet mix liquid stabilization system of Comparative Example 33. DETAILED DESCRIPTION

[0032] The technical solution of the present invention is further described below in conjunction with the embodiments, but it is not limited thereto. Any modification or equivalent replacement of the technical solution of the present invention without departing from the spirit and scope of the technical solution of the present invention shall be included in the protection scope of the present invention. The process equipment or devices not specifically noted in the following embodiments are all conventional equipment or devices in the art. If not specifically specified, the raw materials used in the embodiments of the present invention can be obtained commercially; if not specifically specified, the technical means used in the embodiments of the present invention are all conventional means well known to those skilled in the art.

[0033] Example 1

[0034] This embodiment provides a wet mix liquid stabilization system and a preparation method thereof.

[0035] In this embodiment, the raw materials for preparing 1000 parts by weight of the powdered wet mix liquid stabilization system include 2105 parts of raw cow's milk, 247 parts of maltodextrin, 210 parts of edible vegetable blending oil, 150 parts of desalted whey powder, 65 parts of type 80 whey protein powder, 55 parts of α-lactalbumin whey protein powder, 7.54 parts of compound vitamin nutritional supplements and 28 parts of compound mineral nutritional supplements.

[0036] The pH of the wet mix liquid stabilization system of this embodiment is 6.86.

[0037] The compound vitamin nutritional supplement in this embodiment contains the following components: 2.49wt% retinyl acetate, 1.34wt% cholecalciferol, 10.73wt% dl-α-tocopherol acetate, 0.15wt% phytonadione, 0.17wt% thiamine hydrochloride, 2.29wt% riboflavin, 3.57wt% pyridoxine hydrochloride, 0.0013wt% hydrocobalamin, 2.73wt% niacinamide, 0.38wt% folic acid, 0.88wt% D-calcium pantothenate, 19.85wt% L-sodium ascorbate, 0.32wt% D-biotin, 21.41wt% inositol, 5.07wt% taurine, 19.23wt% choline chloride and 1.19wt% L-carnitine, and the remaining parts are made up by maltodextrin to 7.54 parts of compound vitamin nutritional supplements contained in the formula food.

[0038] The compound mineral nutritional supplement in this embodiment contains the following components: 21.43wt% sodium citrate, 5.5wt% sodium chloride, 10.16wt% potassium chloride, 1.34wt% copper sulfate, 3.61wt% magnesium sulfate, 1.73wt% ferrous sulfate, 0.82wt% zinc sulfate, 0.10wt% manganese sulfate, 1.06wt% potassium iodide, 0.30wt% sodium selenite, 4.94wt% calcium carbonate and 34.69wt% tricalcium phosphate, and the remaining parts are made up by maltodextrin to make up 28 parts of compound mineral nutritional supplements contained in the formula food.

[0039] The amount of sodium citrate added to the composite mineral nutritional supplement of this embodiment is equivalent to providing 3.77 parts of citrate for 1000 parts by weight of the powdered wet mix liquid stabilization system.

[0040] The specific method for preparing the powdered semi-finished product / finished product of premature / low birth weight infant formula food by the wet mixed liquid stabilization system of this embodiment is as follows: all the raw materials of the wet mixed liquid stabilization system of this embodiment are mixed by a vacuum mixing system to obtain a wet mixed liquid, and the dry matter content of the obtained wet mixed liquid is 17.1%; the obtained wet mixed liquid is homogenized at a homogenization temperature of 40° C. and a homogenization pressure of 180 bar; the homogenized wet mixed liquid is cooled to 4° C., and the homogenized wet mixed liquid is sterilized at a sterilization temperature of 95° C. The dry matter content of the concentrated liquid after concentration by an evaporator is 43%; the obtained concentrated liquid is sent to a spray drying tower for spray drying to obtain a powdered semi-finished product / finished product prepared by the wet mixed liquid stabilization system.

[0041] Example 2

[0042] This embodiment provides a wet mix liquid stabilization system and a preparation method thereof.

[0043] In this embodiment, the raw materials for preparing 1000 parts by weight of the powdered wet mix liquid stabilization system include 2700 parts of raw cow's milk, 235 parts of maltodextrin, 130 parts of edible vegetable blending oil, 170 parts of desalted whey powder, 70 parts of type 80 whey protein powder, 60 parts of α-lactalbumin whey protein powder, 4.8 parts of compound vitamin nutritional supplements and 17.5 parts of compound mineral nutritional supplements.

[0044] The pH of the wet mix liquid stabilization system of this embodiment is 6.78.

[0045] The compound vitamin nutritional supplement in this embodiment contains the following components: 1.28wt% retinyl acetate, 1.68wt% cholecalciferol, 6.83wt% dl-α-tocopherol acetate, 0.29wt% phytonadione, 0.21wt% thiamine hydrochloride, 0.50wt% riboflavin, 2.69wt% pyridoxine hydrochloride, 0.0396wt% hydrocobalamin, 1.13wt% niacinamide, 0.29wt% folic acid, 0.83wt% D-calcium pantothenate, 25.00wt% L-sodium ascorbate, 0.48wt% D-biotin, 11.67wt% inositol, 10.42wt% taurine, 31.25wt% choline chloride and 2.08wt% L-carnitine, and the remaining parts are made up by maltodextrin to 4.8 parts of compound vitamin nutritional supplements contained in the formula food.

[0046] The compound mineral nutritional supplement in this embodiment contains the following components: 30.86wt% sodium citrate, 8.00wt% sodium chloride, 9.71wt% potassium chloride, 0.20wt% copper sulfate, 5.71wt% magnesium sulfate, 2.46wt% ferrous sulfate, 2.13wt% zinc sulfate, 0.27wt% manganese sulfate, 1.47wt% potassium iodide, 0.59wt% sodium selenite, 17.14wt% calcium carbonate and 11.43wt% tricalcium phosphate, and the remaining parts are made up by maltodextrin to make up 17.5 parts of compound mineral nutritional supplements contained in the formula food.

[0047] The amount of sodium citrate added to the composite mineral nutritional supplement of this embodiment is equivalent to providing 3.40 parts of citrate for 1000 parts by weight of the powdered wet mix liquid stabilization system.

[0048] The specific method for preparing the powdered semi-finished product / finished product of premature / low birth weight infant formula food by the wet mix liquid stabilization system of this embodiment is as follows: the dry matter content of the wet mix liquid obtained by the wet mix liquid stabilization system of this embodiment is 17.1%; the obtained wet mix liquid is homogenized at a homogenization temperature of 40° C. and a homogenization pressure of 180 bar; the homogenized wet mix liquid is cooled to 4° C., the homogenized wet mix liquid is sterilized at a sterilization temperature of 95° C., the dry matter content of the concentrated liquid after concentration by an evaporator is 43%, and the obtained concentrated liquid is sent to a spray drying tower for spray drying to obtain a powdered semi-finished product / finished product prepared by the wet mix liquid stabilization system.

[0049] Example 3

[0050] This embodiment provides a wet mix liquid stabilization system and a preparation method thereof.

[0051] In this embodiment, the raw materials for preparing 1000 parts by weight of the powdered wet mix liquid stabilization system include 1650 parts of raw cow's milk, 300 parts of maltodextrin, 300 parts of edible vegetable blending oil, 200 parts of desalted whey powder, 20 parts of type 80 whey protein powder, 70 parts of α-lactalbumin whey protein powder, 5.2 parts of compound vitamin nutritional supplements and 18 parts of compound mineral nutritional supplements.

[0052] The pH of the wet mix liquid stabilization system of this embodiment is 6.57.

[0053] The compound vitamin nutritional supplement in this embodiment contains the following components: 1.18wt% retinyl acetate, 1.55wt% cholecalciferol, 6.30wt% dl-α-tocopherol acetate, 0.27wt% phytonadione, 0.19wt% thiamine hydrochloride, 0.46wt% riboflavin, 2.49wt% pyridoxine hydrochloride, 0.0365wt% hydrocobalamin, 1.04wt% niacinamide, 0.27wt% folic acid, 0.77wt% D-calcium pantothenate, 30.77wt% L-sodium ascorbate, 0.44wt% D-biotin, 10.77wt% inositol, 9.62wt% taurine, 28.85wt% choline chloride and 1.92wt% L-carnitine, and the remaining parts are made up by maltodextrin to 5.2 parts of the compound vitamin nutritional supplement contained in the formula food.

[0054] The compound mineral nutritional supplement in this embodiment contains the following components: 26.86wt% sodium citrate, 11.43wt% sodium chloride, 13.14wt% potassium chloride, 0.20wt% copper sulfate, 5.71wt% magnesium sulfate, 2.46wt% ferrous sulfate, 2.13wt% zinc sulfate, 0.27wt% manganese sulfate, 1.47wt% potassium iodide, 0.59wt% sodium selenite, 17.14wt% calcium carbonate and 11.43wt% tricalcium phosphate, and the remaining parts are made up by maltodextrin to make up 18 parts of compound mineral nutritional supplements contained in the formula food.

[0055] The amount of sodium citrate added to the composite mineral nutritional supplement of this embodiment is equivalent to providing 3.0 parts of citrate to 1000 parts by weight of the powdered wet mixed liquid stabilization system.

[0056] The specific method for preparing the powdered semi-finished product / finished product of premature / low birth weight infant formula food by the wet mix liquid stabilization system of this embodiment is as follows: the dry matter content of the wet mix liquid obtained by the wet mix liquid stabilization system of this embodiment is 17.1%; the obtained wet mix liquid is homogenized at a homogenization temperature of 40° C. and a homogenization pressure of 180 bar; the homogenized wet mix liquid is cooled to 4° C., the homogenized wet mix liquid is sterilized at a sterilization temperature of 95° C., the dry matter content of the concentrated liquid after concentration by an evaporator is 43%, and the obtained concentrated liquid is sent to a spray drying tower for spray drying to obtain a powdered semi-finished product / finished product prepared by the wet mix liquid stabilization system.

[0057] Example 4

[0058] This embodiment provides a wet mix liquid stabilization system and a preparation method thereof.

[0059] In this embodiment, the raw materials for preparing 1000 parts by weight of the powdered wet mix liquid stabilization system include 3200 parts of raw cow's milk, 350 parts of maltodextrin, 60 parts of edible vegetable blending oil, 50 parts of desalted whey powder, 140 parts of type 80 whey protein powder, 20 parts of α-lactalbumin whey protein powder, 4.8 parts of compound vitamin nutritional supplements and 14 parts of compound mineral nutritional supplements.

[0060] The pH of the wet mix liquid stabilization system of this embodiment is 6.74.

[0061] The compound vitamin nutritional supplement in this embodiment contains the following components: 1.49wt% retinyl acetate, 1.68wt% cholecalciferol, 6.83wt% dl-α-tocopherol acetate, 0.30wt% phytonadione, 0.21wt% thiamine hydrochloride, 0.50wt% riboflavin, 2.74wt% pyridoxine hydrochloride, 0.0396wt% hydrocobalamin, 1.13wt% niacinamide, 0.27wt% folic acid, 0.83wt% D-calcium pantothenate, 25.00wt% L-sodium ascorbate, 0.48wt% D-biotin, 11.67wt% inositol, 10.42wt% taurine, 31.25wt% choline chloride and 2.08wt% L-carnitine, and the remaining parts are made up by maltodextrin to 4.8 parts of compound vitamin nutritional supplements contained in the formula food.

[0062] The compound mineral nutritional supplement in this embodiment contains the following components: 19.43wt% sodium citrate, 3.71wt% potassium chloride, 0.15wt% copper sulfate, 2.86wt% magnesium sulfate, 3.73wt% ferrous sulfate, 2.06wt% zinc sulfate, 0.27wt% manganese sulfate, 1.35wt% potassium iodide, 0.51wt% sodium selenite, 20.00wt% calcium carbonate and 11.43wt% tricalcium phosphate, and the remaining parts are made up by maltodextrin to make up 14 parts of compound mineral nutritional supplements contained in the formula food.

[0063] The amount of sodium citrate added to the composite mineral nutritional supplement of this embodiment is equivalent to providing 2.13 parts of citrate for 1000 parts by weight of the powdered wet mix liquid stabilization system.

[0064] The specific method for preparing the powdered semi-finished product / finished product of premature / low birth weight infant formula food by the wet mix liquid stabilization system of this embodiment is as follows: the dry matter content of the wet mix liquid obtained by the wet mix liquid stabilization system of this embodiment is 17.1%; the obtained wet mix liquid is homogenized at a homogenization temperature of 40° C. and a homogenization pressure of 180 bar; the homogenized wet mix liquid is cooled to 4° C., the homogenized wet mix liquid is sterilized at a sterilization temperature of 95° C., the dry matter content of the concentrated liquid after concentration by an evaporator is 43%, and the obtained concentrated liquid is sent to a spray drying tower for spray drying to obtain a powdered semi-finished product / finished product prepared by the wet mix liquid stabilization system.

[0065] Comparative Example 1

[0066] The only difference between this comparative example and Example 1 is that the composite mineral nutritional supplement in this comparative example contains the following components: 22.25wt% sodium citrate, 4.79wt% sodium chloride and 9.45wt% potassium chloride, the amount of sodium citrate added in the composite mineral nutritional supplement in this comparative example is equivalent to providing 3.9 parts of citrate for 1000 parts by weight of the powdered wet mix liquid stabilization system, and the pH of the wet mix liquid stabilization system in this comparative example is 6.78.

[0067] Comparative Example 2

[0068] This comparative example provides a wet mix liquid stabilization system and a preparation method thereof.

[0069] In this comparative example, the raw materials for preparing 1000 parts by weight of the powdered wet mix liquid stabilization system include 2105 parts of raw cow's milk, 245 parts of maltodextrin, 210 parts of edible vegetable blending oil, 150 parts of desalted whey powder, 65 parts of type 80 whey protein powder, 55 parts of α-lactalbumin whey protein powder, 9 parts of compound vitamin nutritional supplements and 28 parts of compound mineral nutritional supplements.

[0070] The pH of the wet mixed liquid stabilization system of this comparative example is 6.48.

[0071] The compound vitamin nutritional supplement in this comparative example contains the following components: 2.30wt% retinyl acetate, 1.35wt% cholecalciferol, 8.99wt% dl-α-tocopherol acetate, 0.13wt% phytonadione, 0.14wt% thiamine hydrochloride, 1.92wt% riboflavin, 2.99wt% pyridoxine hydrochloride, 0.0011wt% hydrogen cobalamin, 2.29wt% niacinamide, 0.31wt% folic acid, 0.74wt% D-calcium pantothenate, 14.97wt% L-ascorbic acid, 0.27wt% D-biotin, 17.93wt% inositol, 4.25wt% taurine, 29.72wt% choline bitartrate and 1.46wt% L-carnitine tartrate, and the remaining parts are made up by maltodextrin to make up the 9 parts of compound vitamin nutritional supplements contained in the formula food.

[0072] The compound mineral nutritional supplement in this comparative example contains the following components: 11.79wt% sodium citrate, 10.25wt% sodium chloride, 10.16wt% potassium chloride, 1.34wt% copper sulfate, 3.61wt% magnesium sulfate, 1.73wt% ferrous sulfate, 0.82wt% zinc sulfate, 0.10wt% manganese sulfate, 1.06wt% potassium iodide, 0.30wt% sodium selenite, 4.94wt% calcium carbonate and 34.69wt% tricalcium phosphate, and the remaining parts are supplemented by maltodextrin to make up 28 parts of compound mineral nutritional supplements contained in the formula food.

[0073] The amount of sodium citrate added in the composite mineral nutritional supplement of this comparative example is equivalent to providing 2.10 parts of citrate roots for 1000 parts by weight of the powdered wet mixed liquid stabilization system.

[0074] The specific method for preparing the powdered semi-finished / finished product of premature / low birth weight infant formula food from the wet mix liquid stabilization system of this comparative example is the same as that in Example 1.

[0075] Comparative Example 3

[0076] The difference between this comparative example and Example 1 is that potassium hydroxide is used to adjust the pH of the wet mixed liquid stabilization system to 7.10.

[0077] Comparative Example 4

[0078] The difference between this comparative example and Example 1 is that the composite mineral nutritional supplement in this comparative example contains the following components: 12.50wt% sodium citrate, 9.53wt% sodium chloride and 8.81wt% potassium chloride, the amount of sodium citrate added in the composite mineral nutritional supplement in this comparative example is equivalent to providing 2.2 parts of citrate for 1000 parts by weight of the powdered wet mix liquid stabilization system, and the pH of the wet mix liquid stabilization system in this comparative example is 6.37.

[0079] Effect Example 1

[0080] Observation and statistics were performed on Examples 1 to 4 and Comparative Examples 1 to 4, and the results are shown in Table 1.

[0081] Table 1

[0082]

[0083]

[0084] As can be seen from Table 1, only Examples 1 to 4 using the method of the present invention can obtain a stable wet mix liquid without protein denaturation, while Comparative Examples 1 to 4 not using the method of the present invention all have varying degrees of protein denaturation and flocculation in the wet mix liquid. It can be seen that the present invention has unexpectedly improved the heat resistance and thermal stability of the wet mix liquid system with high protein content and high whey protein content by adjusting the citrate content and pH value in the wet mix liquid system.

[0085] Effect Example 2

[0086] Figure 1 The following is a photograph of the appearance of the wet mix liquid after the DSI sterilization process in Example 1; as shown in the figure, when 3.77 parts of citric acid are provided by the wet mix liquid with a high whey protein content and the pH of the wet mix liquid is 6.86, the wet mix liquid is uniformly milky white after high-temperature sterilization, and no foreign matter, small particles, flocculation or agglomeration is observed. This proves that the present invention greatly improves the heat resistance and stability of the wet mix liquid with a high whey protein content after high-temperature sterilization.

[0087] Figure 7 This is a photograph of the appearance of the wet mix liquid of Comparative Example 3 after the DSI sterilization process; as shown in the figure, the 3.77 parts of citrate provided by the wet mix liquid with a high whey protein content is the same as the citrate content provided in Example 1, but when the pH of the wet mix liquid is 7.10, a large amount of coagulum is generated after the wet mix liquid is sterilized at high temperature, proving that a wet mix liquid system with a high whey protein content having heat resistance and stability cannot be prepared at this pH value.

[0088] Figure 2 This is a photo of the appearance of the wet mix of Example 2 after the DSI sterilization process; as shown in the figure, when 3.40 parts of citric acid are provided by the wet mix with a high whey protein content and the pH of the wet mix is ​​6.78, the wet mix is ​​uniformly milky white after high-temperature sterilization, and no foreign matter, small particles, flocculation or agglomeration is observed. This proves that the present invention greatly improves the heat resistance and stability of the wet mix with a high whey protein content after high-temperature sterilization.

[0089] Figure 5This is a photograph of the appearance of the wet mix liquid of Comparative Example 1 after the DSI sterilization process; as shown in the figure, when 3.90 parts of citrate are provided by the wet mix liquid with a high whey protein content and the pH is the same as that in Example 2, both are 6.78, small white particles visible to the naked eye appear in the wet mix liquid after high-temperature sterilization, proving that it is impossible to prepare a wet mix liquid system with a high whey protein content that is heat-resistant and stable at this citrate content.

[0090] Figure 3 The following is a photograph of the appearance of the wet mix of Example 3 after the DSI sterilization process; as shown in the figure, when 3.00 parts of citric acid are provided by the wet mix with a high whey protein content and the pH of the wet mix is ​​6.57, the wet mix is ​​uniformly milky white after high-temperature sterilization, and no foreign matter, small particles, flocculation or agglomeration is observed. This proves that the present invention greatly improves the heat resistance and stability of the wet mix with a high whey protein content after high-temperature sterilization.

[0091] Figure 4 The following is a photograph of the appearance of the wet mix of Example 4 after the DSI sterilization process; as shown in the figure, when 2.13 parts of citric acid are provided by the wet mix with a high whey protein content and the pH of the wet mix is ​​6.74, the wet mix is ​​uniformly milky white after high-temperature sterilization, and no foreign matter, small particles, flocculation or agglomeration is observed. This proves that the present invention greatly improves the heat resistance and stability of the wet mix with a high whey protein content after high-temperature sterilization.

[0092] Figure 6 This is a photo of the appearance of the wet mix of Comparative Example 2 after the DSI sterilization process; as shown in the figure, when 2.10 parts of citrate are provided from the wet mix with a high whey protein content and the pH is 6.48, a large amount of floccules visible to the naked eye are produced after the wet mix is ​​sterilized at high temperature. It is proved that it is impossible to prepare a wet mix system with a high whey protein content that is heat-resistant and stable at this citrate content.

[0093] Figure 8 This is a photo of the appearance of the wet mix of Comparative Example 4 after the DSI sterilization process; as shown in the figure, when 2.13 parts of citrate are provided by the wet mix with high whey protein content and the pH is 6.35, a large amount of floccules visible to the naked eye are produced after the wet mix is ​​sterilized at high temperature. It is proved that it is impossible to prepare a wet mix system with high whey protein content that is heat-resistant and stable at this pH value.

[0094] Effect Example 3

[0095] The powdery semi-finished product / finished product prepared by the wet mix liquid stabilization system of Example 1 was prepared by standard preparation. Specifically, 15.9 g of the powdery semi-finished product / finished product was accurately weighed and fully dissolved in 90 mL of warm water at about 45°C to obtain a preparation liquid. The appearance of the preparation liquid was observed. The results were as follows: Fig. 9As shown, the standard preparation liquid is uniform milky white, and no obvious foreign matter or small white particles are found, which proves that the present invention greatly improves the problem of a large number of white spots generated after the spray-dried formula food is prepared.

[0096] The powdered semi-finished product / finished product prepared by the wet mixed liquid stabilization system of Comparative Example 3 was prepared by standard preparation, and the appearance of the prepared liquid of Comparative Example 3 was observed. The results are as follows: Fig.10 As shown, there are very small visible white granular substances suspended in the standard dissolving liquid, which proves that the wet mixed liquid with the citrate content and pH value cannot prepare a product with good dissolving properties after spray drying.

[0097] Effect Example 4

[0098] The powdery semi-finished products / finished products obtained in Examples 1 to 4 of the present invention and Comparative Examples 1 to 4 were used for standard preparation, and the osmotic pressure of the standard preparation liquid was observed and statistically analyzed. The results are shown in Table 2:

[0099] Table 2

[0100]

[0101]

[0102] The results of the osmotic pressure measurement of the above-mentioned standard reconstituted liquid indicate that, under the premise of ensuring that the osmotic pressure of the final product is suitable for the needs of premature infants, the citrate content and pH value in the wet mix liquid system can be adjusted by the method of the present invention, thereby achieving unexpected effects such as improving the heat resistance of the wet mix liquid system with high protein content and high whey protein content, and the stability with other proteins at high temperatures.

[0103] The wet mix liquid stabilization system provided by the invention and the application thereof in formula food for premature / low birth weight infants can be implemented in industry.

[0104] The above disclosure is only a preferred embodiment of the present invention, which cannot be used to limit the scope of rights of the present invention. Therefore, any changes, modifications, combinations, and simplifications made according to the claims and principles of the present invention are equivalent changes and still fall within the protection scope of the present invention.

Claims

1. A wet mix liquid stabilization system, characterized in that: The raw materials for preparing 1000 parts by weight of a powdered wet mix liquid stabilizing system include 1650-3250 parts of raw cow milk, 30-450 parts of desalted whey powder, 20-200 parts of whey protein powder, 60-300 parts of edible vegetable blending oil, 80-350 parts of maltodextrin, 3-15 parts of compound vitamin nutritional supplements and 10-40 parts of compound mineral nutritional supplements; the 1000 parts by weight of the powdered wet mix liquid stabilizing system contains citrate provided by compounds derived from sodium and potassium elements, and the content of the citrate is 2.13-3.77 parts.

2. A wet mix liquid stabilization system according to claim 1, characterized in that: The pH of the wet mixed liquid stabilization system is 6.40-7.

00.

3. A wet mix liquid stabilization system according to claim 1 or 2, characterized in that: The dry matter content of the raw cow's milk is 12%; the whey protein powder is one or more of whey protein powder type 80, whey protein powder containing α-lactalbumin, whey protein powder containing milk fat globule membrane protein or hydrolyzed whey protein powder; the edible vegetable blending oil is one or more of vegetable oil, medium-chain triglyceride or 1,3-dioleyl-2-palmityl triglyceride.

4. A wet mix liquid stabilization system according to claim 3, characterized in that: The components of the compound vitamin nutritional supplement include one or more of retinyl acetate, cholecalciferol, tocopherol acetate, phytonadione, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, hydrocobalamin, niacinamide, folic acid, D-calcium pantothenate, L-sodium ascorbate, biotin, inositol, sulfonic acid, choline and L-carnitine.

5. A wet mix liquid stabilization system according to claim 4, characterized in that: The compound vitamin nutritional supplement contains 0.50-5.00wt% retinyl acetate, 0.60-4.00wt% cholecalciferol, 3.00-22.00wt% dl-α-tocopherol acetate, 0.05-0.60wt% phytonadione, 0.05-0.50wt% thiamine hydrochloride, 0.20-5.00wt% riboflavin, 1.00-8.00wt% pyridoxine hydrochloride, and 0-0.10wt% hydrocobalamin. , 0.50-6.00wt% niacinamide, 0.10-0.80wt% folic acid, 0.30-1.80wt% D-calcium pantothenate, 7.00-40.00wt% L-sodium ascorbate, 0.10-1.00wt% D-biotin, 5.00-30.00wt% inositol, 2.00-15.00wt% taurine, 9.00-35.00wt% choline chloride and 0.50-5.00wt% L-carnitine.

6. A wet mix liquid stabilization system according to claim 5, characterized in that: The compound of the sodium element source in the compound mineral nutritional supplement is sodium citrate and / or sodium chloride; the compound of the potassium element source is potassium citrate and / or potassium chloride; the compound mineral nutritional supplement contains 3.00-43.00wt% of sodium citrate and / or potassium citrate, 0-23.00wt% of sodium chloride and 3-46wt% of potassium chloride.

7. A wet mix liquid stabilization system according to claim 6, characterized in that: The composite mineral nutritional supplement also contains 0-3.00wt% copper sulfate, 1.50-12.00wt% magnesium sulfate, 0.50-10.00wt% ferrous sulfate, 0.40-5.50wt% zinc sulfate, 0.05-0.70wt% manganese sulfate, 0.50-3.50wt% potassium iodide, 0.10-1.50wt% sodium selenite, 2.00-35.00wt% calcium carbonate and 5.00-45.00wt% tricalcium phosphate.

8. Use of the wet mix liquid stabilizing system according to claims 1 to 7 in formula food for premature / low birth weight infants.

9. The use of a wet mix liquid stabilization system according to claim 8 in formula food for premature / low birth weight infants, characterized in that: The method for preparing the powdered semi-finished product / finished product of the formula food for premature / low birth weight infants comprises the following steps: mixing all raw materials of the wet mixed liquid stabilization system as described in claims 1 to 7 through a vacuum mixing system to obtain a wet mixed liquid, wherein the dry matter content of the obtained wet mixed liquid is 15.5-18.5%; homogenizing the obtained wet mixed liquid at a homogenization temperature of 35-65° C. and a homogenization pressure of 140-210 bar, and cooling the wet mixed liquid to 0-8° C. for standby use after homogenization; sterilizing the homogenized wet mixed liquid at a sterilization temperature of 85-100° C., and the dry matter content of the concentrated liquid after concentration by an evaporator is 38-45%, and sending the obtained concentrated liquid to a spray drying tower for spray drying to obtain a powdered semi-finished product / finished product prepared by the wet mixed liquid stabilization system.

10. The use of the wet mix liquid stabilization system according to claim 9 in formula food for premature / low birth weight infants, characterized in that: The osmotic pressure of the standard preparation solution of the premature / low birth weight infant formula food is less than 300 mOsmol / kg.

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