Flexible microelectrode implantation device, implantation equipment and implantation system

Abstract

The invention relates to a flexible microelectrode implantation device, implantation equipment and an implantation system. The implantation device comprises a base, a plurality of implantation needle assemblies, a plurality of flexible microelectrodes and an implantation control piece. Each implantation needle assembly comprises a fixed seat and an auxiliary implantation needle which are connected with each other, the multiple fixed seats are detachably connected to the base, and each auxiliary implantation needle is connected with one flexible microelectrode; the implantation control piece comprises a first magnetic piece, each fixing seat comprises a second magnetic piece, the implantation control piece is magnetically attracted to the second magnetic piece on each fixing seat through the first magnetic piece, then each fixing seat and the corresponding auxiliary implantation needle are driven to be separated from the base, and the corresponding flexible microelectrode is implanted to a preset position of a brain area. By means of the arrangement, the implantation area and the implantation depth of each auxiliary implantation needle can be dynamically selected, rapid implantation of a single auxiliary implantation needle can be achieved in a magnetic attraction control mode, and the implantation efficiency cannot be reduced.

Description

Technical Field

[0001] The present application relates to the technical field of electrode implantation, and in particular to a flexible microelectrode implantation device, an implantation apparatus and an implantation system. Background Art

[0002] As an interdisciplinary technology, brain-computer interface has received widespread attention from the scientific research and industrial communities around the world. As the first choice for brain-computer interface, flexible microelectrodes have the biggest advantage of not easily forming scars in brain tissue. However, since flexible microelectrodes themselves have low mechanical strength and are easy to deform, it is not easy for them to pass through the meninges and enter the tissue. Therefore, auxiliary implantation needles are usually used to assist the implantation of flexible microelectrodes.

[0003] Chinese patent application CN115736935A involves a brain electrode implantation device and a brain electrode implantation system, which utilizes a control circuit board to connect with multiple flexible microelectrodes, and utilizes a base to fix multiple auxiliary implantation needles, and utilizes the corresponding connection between the flexible microelectrodes and the auxiliary implantation needles to realize the implantation of the flexible microelectrodes into the brain area assisted by the implanter. Combined with its specification, it can be known that the problem that is more likely to occur in actual operation is that when there are multiple auxiliary implantation needles, the implantation area and implantation depth of each auxiliary implantation needle cannot be dynamically selected, and all auxiliary implantation needles can only be inserted into the brain area within the preset range, which may cause some flexible microelectrodes to be implanted outside the measured brain area, and cannot be too vertical and horizontal according to the needs. The implantation depth and implantation position of each flexible microelectrode may interfere with the blood vessels, thereby puncturing the blood vessels and causing bleeding. Summary of the invention

[0004] In view of this, the present application proposes a flexible microelectrode implantation device, an implantation apparatus and an implantation system, which can at least solve the technical problem of dynamically selecting the implantation area and implantation depth of each auxiliary implantation needle when a base is used to fix multiple auxiliary implantation needles without reducing the implantation efficiency.

[0005] According to one aspect of the present application, a flexible microelectrode implantation device is provided, the flexible microelectrode implantation device comprising a base, a plurality of implantation needle assemblies, a plurality of flexible microelectrodes and an implantation control member;

[0006] Each of the implant needle assemblies comprises a fixing seat and an auxiliary implant needle connected to each other, the fixing seats of the implant needle assemblies can be detachably connected to the base, and the auxiliary implant needle of each implant needle assembly is respectively connected to one of the flexible microelectrodes;

[0007] The implant control component includes a first magnetic component, and each of the fixing seats includes a second magnetic component. The implant control component is magnetically attracted to the second magnetic component on each of the fixing seats through the first magnetic component, thereby driving each of the fixing seats and the corresponding auxiliary implant needle to detach from the base, thereby realizing the implantation of the corresponding flexible microelectrode into a preset position in the brain area.

[0008] Furthermore, the auxiliary implantation needle is a silk protein needle, and the auxiliary implantation needle is connected to the fixing seat via a biosoluble glue;

[0009] Alternatively, the auxiliary implantation needle is a tungsten needle, and the auxiliary implantation needle is connected to the fixing seat via a non-biosoluble glue.

[0010] Furthermore, the base is provided with a plurality of slots, and the side wall of the base is provided with a plurality of through openings connected to each of the slots, each of the fixing seats is inserted into one of the slots along a preset direction, and the implant control member drives each of the fixing seats to disengage from the corresponding slot along the preset direction.

[0011] Furthermore, the preset direction is the axial direction of the slot, and in the axial direction of the slot, one end of each of the fixing seats is connected to the auxiliary implant needle, and the other end of each of the fixing seats is provided with a receiving groove;

[0012] The second magnetic component is a first magnetic body, and the first magnetic body is fixedly disposed in the receiving groove corresponding to the fixing seat, and the implant control component is magnetically attracted to the fixing seat through the first magnetic body.

[0013] Furthermore, the implant needle assembly also includes a cover, which is arranged on the end surface of the base through which the multiple fixing seats are inserted, and the cover can slide relative to the base to cover part of the slot holes on the base.

[0014] Furthermore, the plurality of slots are arranged in an array on the base along a target direction, and a direction in which the cover slides relative to the base is consistent with the target direction.

[0015] Furthermore, each of the fixing seats is a magnetic body, and each of the fixing seats is inserted into one of the slot holes along the radial direction of the slot hole through the through opening;

[0016] The second magnetic part is a second magnetic body, which is fixedly arranged inside each of the slots. In the axial direction of the slots, one end of each of the fixing seats is connected to the auxiliary implant needle, and the other end of each of the fixing seats is magnetically attracted to the second magnetic body in the corresponding slot.

[0017] Furthermore, the implant control component also includes an adjustment column, the first magnetic component is a third magnetic body, the third magnetic body is connected to the adjustment column, and the adjustment column can adjust the position of the third magnetic body to achieve magnetic attraction of the third magnetic body to the second magnetic component on each of the fixing seats.

[0018] Furthermore, the implant manipulation component also includes a magnet fixing frame, the magnet fixing frame is connected to the end of the adjustment column and can move relative to the adjustment column, and the third magnetic body is arranged on the magnet fixing frame.

[0019] According to another aspect of the present application, a flexible microelectrode implantation device is provided, the flexible microelectrode implantation device comprising:

[0020] The flexible microelectrode implantation device as described above;

[0021] A control circuit board, one end of each of the plurality of flexible microelectrodes is connected to the control circuit board, and the other ends of each of the plurality of flexible microelectrodes are respectively connected to the corresponding auxiliary implantation needles;

[0022] A fastening mechanism is used to locate and adjust the relative position of the control circuit board.

[0023] Furthermore, the fastening mechanism comprises:

[0024] A fastening frame, through which the fastening mechanism is connected to the base of the flexible microelectrode implantation device, and the fastening frame has two fastening parts arranged opposite to each other;

[0025] A tightening block, wherein the tightening block and the control circuit board are both arranged between the two tightening parts, and the tightening block can clamp and fix the control circuit board by adjusting the distance between the tightening block and the adjacent tightening parts.

[0026] Furthermore, threaded holes are correspondingly provided on the fixing block and the fixing portion adjacent thereto, and a pin hole is also provided on the fixing block, and the pin hole is perpendicular to and connected to the threaded hole on the fixing block;

[0027] The fastening mechanism also includes a modified screw and a pin shaft. The modified screw is provided with an annular groove. The modified screw passes through the threaded holes on the fastening portion and the fixing block in sequence. The pin shaft passes through the pin hole and is engaged in the annular groove.

[0028] Furthermore, the fastening mechanism includes a fastening body, the control circuit board is inserted into the fastening body, the fastening body is made of elastic material, and can apply a clamping force to the control circuit board under the action of an external force.

[0029] Furthermore, the fastening body and the base are integrally formed by 3D printing.

[0030] According to another aspect of the present application, a flexible microelectrode implantation system is provided, the flexible microelectrode implantation system comprising:

[0031] A flexible microelectrode implant device as described above;

[0032] A positioning device is connected to the implantation control member and the fastening mechanism of the flexible microelectrode implantation device, and can perform positioning and adjustment on the implantation control member and the fastening mechanism.

[0033] Furthermore, the positioning device includes an electromagnet, and the positioning device is connected to the implant control member through the electromagnet, and the electromagnet drives the implant control member to move through electromagnetic attraction and disconnection.

[0034] The beneficial effects of this application are:

[0035] By setting a base to pre-fix multiple fixing seats of multiple implant needle assemblies, the auxiliary implant needles connected to each fixing seat together with the corresponding flexible microelectrodes can also be fixed in position relative to the base, and then the first magnetic member on the implant control member and the second magnetic member on each fixing seat are magnetically attracted, so that the auxiliary implant needles connected to the magnetically attracted fixing seat are separated from the base, thereby assisting the corresponding flexible microelectrodes to be implanted into the preset position of the brain area to complete the implantation of a single electrode; through this setting, when it is necessary to implant multiple flexible microelectrodes, the implant control member can be used to individually control each fixing seat, thereby realizing dynamic selection of the implantation area and implantation depth of each auxiliary implant needle, and compared with other control methods, this magnetic control method can realize rapid implantation of a single electrode without reducing the efficiency of implantation. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] In order to more clearly illustrate the technical solution of the present application, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are merely embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0037] Figure 1 This is a schematic diagram of the overall structure of the flexible microelectrode implantation device of Example 1 of the present application.

[0038] Figure 2 This is a schematic diagram of the overall structure explosion of the flexible microelectrode implantation device of Example 1 of the present application.

[0039] Figure 3 This is a schematic diagram of the structure of the flexible microelectrode implantation device of Example 1 of the present application at the location of the implantation needle assembly.

[0040] Figure 4 This is a schematic diagram of the structure of the base in the flexible microelectrode implantation device of Example 1 of the present application (I).

[0041] Figure 5 This is a schematic diagram of the structure of the base in the flexible microelectrode implantation device of Example 1 of the present application (II).

[0042] Figure 6 This is a schematic diagram of the structure of the cover in the flexible microelectrode implantation device of Example 1 of the present application.

[0043] Figure 7 This is a schematic diagram of the assembly structure of four fixing seats and four auxiliary implantation needles in the flexible microelectrode implantation device of Example 1 of the present application.

[0044] Figure 8 This is a schematic diagram of the structure of the fixing seat in the flexible microelectrode implantation device of Example 1 of the present application.

[0045] Fig. 9 This is a schematic diagram of the structure of the implanted control component in the flexible microelectrode implantation device of Example 1 of the present application.

[0046] Fig.10 This is a schematic diagram of the connection between the control circuit board and the flexible microelectrode of Example 1 of the present application.

[0047] Fig.11 This is a schematic diagram of the structure of the flexible microelectrode implantation device in Example 1 of the present application at the location of the fastening mechanism.

[0048] Fig.12 This is a schematic structural diagram of the fastening frame in the fastening mechanism of Example 1 of the present application.

[0049] Fig.13 This is a schematic diagram of the mechanism of the fastening block in the fastening mechanism of Example 1 of the present application.

[0050] Fig.14 This is a schematic diagram of the structure of the modified screw in the fastening mechanism of Example 1 of the present application.

[0051] Fig.15 This is a schematic diagram of the assembly structure of four fixing seats and four auxiliary implantation needles in the flexible microelectrode implantation device of Example 2 of the present application.

[0052] Fig.16 This is a schematic diagram of the overall structure of the flexible microelectrode implantation device of Example 2 of the present application.

[0053] Fig.17This is a schematic exploded view of the overall structure of the flexible microelectrode implantation device of Example 3 of the present application.

[0054] Fig.18 This is a schematic diagram of the assembly structure of the base and the fastening mechanism of Example 3 of the present application.

[0055] Fig.19 This is a schematic diagram of the assembly structure of four fixing seats and four auxiliary implantation needles in the flexible microelectrode implantation device of Example 3 of the present application.

[0056] Fig. 20 This is a schematic diagram of the assembly structure of the flexible microelectrode implantation device, quick-change parts, and electromagnet of Example 3 of the present application.

[0057] Fig.21 This is a schematic diagram of the assembly structure of the quick-change component and the electromagnet of Example 3 of the present application.

[0058] Fig. 22 This is a structural explosion diagram of the flexible microelectrode implantation device of Example 4 of the present application at the location of the fastening mechanism.

[0059] Fig.23 This is a structural schematic diagram of the flexible microelectrode device of Example 4 of the present application at the location of the fastening mechanism (I).

[0060] Fig.24 This is a structural schematic diagram of the flexible microelectrode device of Example 4 of the present application at the location of the fastening mechanism (II).

[0061] Among them, the reference numerals in the figure correspond to: base-1, slot-11, guide block-12, adjustment hole-13, second fastening hole-14, implant needle assembly-2, cover-21, adjustment screw-211, guide groove-212, sliding groove-213, fixing seat-22, first magnetic body-221, accommodating groove-222, auxiliary implant needle-23, fixing column-3, flexible microelectrode-4, magnet fixing frame-51, adjustment column-52, third magnetic body-53, fixing frame-61, fixing part-611 , protrusion-612, threaded hole-613, column mounting hole-614, fastening screw mounting hole-615, first fastening hole-616, guide hole-617, fastening block-62, fixing protrusion-621, pin hole-622, modified screw-63, annular groove-631, guide screw-64, pin shaft-65, fastening screw-66, fastening body-67, insertion slot-671, first clamping screw-672, second clamping screw-673, control circuit board-7, electromagnet-8, quick change part-9. DETAILED DESCRIPTION

[0062] The following will be combined with the drawings in this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the described embodiments are only part of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0063] Example 1

[0064] like Figure 1 and Figure 2 As shown, this embodiment provides a flexible microelectrode implantation device including a flexible microelectrode implantation device. In addition to the flexible microelectrode implantation device, the flexible microelectrode implantation device also includes a fastening mechanism and a control circuit board 7. The fastening mechanism mainly includes a fastening frame 61 and a fastening block 62. The flexible microelectrode implantation device is described in detail below.

[0065] like Figure 1-Figure 3 As shown, the flexible microelectrode implantation device mainly includes a base 1, four implantation needle assemblies 2, four flexible microelectrodes 4 and an implantation control member, and the implantation control member mainly includes a magnet fixing frame 51, an adjustment column 52 and a first magnetic member (third magnetic body 53). Each implantation needle assembly 2 includes a fixing seat 22 and an auxiliary implantation needle 23 connected to each other. When the number of implantation needle assemblies 2 is set to four, the number of corresponding fixing seats 22 and auxiliary implantation needles 23 is also four respectively. These fixing seats 22 can be detachably connected to the base 1, and each auxiliary implantation needle 23 is respectively connected to one of the flexible microelectrodes 4. The first magnetic member in the implantation control member is specifically the third magnetic body 53 in this embodiment, and each fixing seat 22 includes a second magnetic member. In this embodiment, the second magnetic member is specifically the first magnetic body 221. It should be noted that the magnetic body mentioned in this embodiment mainly refers to an object with magnetic force, which is used to absorb and fix magnetic bodies such as iron, cobalt, and nickel. The implant control member is magnetically attracted to the first magnetic body 221 on each fixing seat 22 through the third magnetic body 53, thereby driving each fixing seat 22 and the corresponding auxiliary implant needle 23 to be separated from the base 1, so that the corresponding flexible microelectrode 4 is implanted into the preset position of the brain area.

[0066] By setting the base 1, the four fixing seats 22 of the four implant needle assemblies 2 are pre-fixed, so that the auxiliary implant needle 23 connected to each fixing seat 22, together with the corresponding flexible microelectrode 4, can also be fixed relative to the base 1, and then the third magnetic body 53 on the implant control member is magnetically attracted to the first magnetic body 221 on each fixing seat 22, so that the magnetically attracted fixing seat 22 together with the auxiliary implant needle 23 thereon is separated from the base 1, and the fixing seat 22 is driven to reach the preset position of the brain area to implant the auxiliary implant needle 23. When the auxiliary implant needle 23 is implanted, the corresponding flexible microelectrode 4 can be driven to be implanted to the preset position of the brain area to complete the implantation of a single flexible microelectrode 4; through this setting, when it is necessary to implant multiple flexible microelectrodes 4, each fixing seat 22 can be individually controlled by the implant control member, so that the implantation area and implantation depth of each auxiliary implant needle 23 can be dynamically selected, and compared with other control methods, this magnetic control method can achieve rapid implantation of a single one without reducing the efficiency of implantation.

[0067] In the present embodiment, the number of implantation needle assemblies 2 and flexible microelectrodes 4 is only an exemplary setting. In other alternative embodiments, the number of implantation needle assemblies 2 and flexible microelectrodes 4 can be adjusted according to actual needs. In addition, the number of implantation needle assemblies 2 and the number of flexible microelectrodes 4 may not be equal. For example, if five implantation needle assemblies 2 are arranged on the base 1, and only four flexible microelectrodes 4 need to be implanted, then the extra implantation needle assembly 2 can be left on the base 1, and will not affect the implantation of the flexible microelectrode 4. Alternatively, if three implantation needle assemblies 2 are arranged on the base 1, and four flexible microelectrodes 4 need to be implanted, then three of them can be implanted using three implantation needle assemblies 2, and then the implantation needle assembly 2 can be installed on the base 1, and the remaining flexible microelectrodes 4 can be implanted.

[0068] In addition, in this embodiment, the first magnetic member is the third magnetic body 53, and the second magnetic member is the first magnetic body 221, both of which have a certain suction force, so that the magnetic attraction is more stable when the fixed seat 22 is removed by the implanted manipulation member, thereby improving the stability of the operation. However, in other alternative embodiments, only one magnetic body can be set, and the other can be set as a magnetic member, as long as the two can be magnetically attracted to each other.

[0069] In this embodiment, the auxiliary implant needle 23 specifically adopts a silk protein needle, and in each implant needle assembly 2, the auxiliary implant needle 23 is connected to the corresponding fixing seat 22 by a biosoluble glue such as protein glue. With this arrangement, when each auxiliary implant needle 23 is implanted using the fixing seat 22, the auxiliary implant needle 23 can be self-degraded in the brain area, and the auxiliary implant needle 23 can be detached from the fixing seat 22 by itself, avoiding the need to remove the auxiliary implant needle 23 after assisting the corresponding flexible microelectrode 4 to be implanted in the brain area, reducing the risk of implantation failure and reducing secondary damage to brain tissue.

[0070] like Figure 4 and Figure 5 As shown, four slots 11 are provided on the base 1 of the flexible microelectrode implantation device, and the slotting directions of the four slots 11 are consistent. Four through openings are provided on the side wall of the base 1, which are connected to each slot 11 respectively. Each through opening is connected to the corresponding slot 11 to form a receiving groove 222 with an approximately "U-shaped" cross-section. A sealing plate support is provided at the bottom of each slot 11, and the base 1 is also provided with a bayonet structure at the position corresponding to each through opening. Each fixing seat 22 is inserted into one of the slots 11 along a preset direction. The sealing plate support and the bayonet structure can prevent the fixing seat 22 from falling from the bottom and side of the slot 11. At this time, the implant control member can drive each fixing seat 22 to detach from the corresponding slot 11 along the preset direction.

[0071] By inserting each fixing seat 22 into the slot 11 on the fixing seat 22 along a preset direction, the stability of the fixing seat 22 relative to the base 1 can be improved. A plurality of through openings connected to each slot 11 are provided on the side wall of the base 1 to facilitate the insertion and removal of the auxiliary implant needle 23 and the flexible microelectrode 4 after the fixing seat 22 is removed. At the same time, the insertion direction of the fixing seat 22 relative to the base 1 is set to limit the fixing seat 22 from being separated from the base 1 in other directions, so that when the multiple fixing seats 22 are magnetically sucked out by using the implant control member, a fixed moving path can be provided, which is more convenient and more efficient.

[0072] like Figure 7 and Figure 8As shown, the overall structure of each fixing seat 22 is a cylindrical structure, and the direction in which the fixing seat 22 penetrates the slot 11 is the axial direction of the slot 11, that is, the axial direction of the fixing seat 22. In the axial direction of the slot 11, one end of each fixing seat 22 is connected to the auxiliary implantation needle 23, and the other end of each fixing seat 22 is provided with a receiving groove 222, and the first magnetic body 221 is fixedly disposed in the receiving groove 222 of each fixing seat 22, and the third magnetic body 53 of the implanted control member is magnetically attracted to each fixing seat 22 through each first magnetic body 221. By setting the penetration direction of the fixing seat 22 relative to the base 1 to the axial direction of the slot 11, when the fixing seat 22 is penetrated and moved relative to the base 1, the fixing seat 22 can drive the auxiliary implantation needle 23 on its axial end to move, and move out of the base 1 through the through opening to avoid interference with the base 1. At the same time, a receiving groove 222 is provided at the other end away from the auxiliary implantation needle 23, and a first magnetic attraction component is fixedly arranged in the receiving groove 222. The implantable control component can be magnetically attracted to the first magnetic attraction component, thereby driving the fixing seat 22 to move and detach from the base 1, which is more convenient and reliable in operation.

[0073] Furthermore, the depth dimension of the receiving groove 222 opened on the fixing seat 22 satisfies: when the first magnetic body 221 is fixedly set in the receiving groove 222, there is a certain distance between the top of the first magnetic body 221 and the top of the fixing seat 22, and the distance dimension can be adjusted according to the size and strength of the first magnetic body 221, and is preferably set to between 0.3mm and 0.5mm, so that a groove space is formed between the first magnetic body 221 and the fixing seat 22. The groove space has a guiding function. When the third magnetic body 53 is magnetically attracted to the first magnetic body 221, the third magnetic body 53 can use the groove space for guidance, so that the third magnetic body 53 and the first magnetic body 221 will not move when they are magnetically attracted to each other, thereby avoiding affecting the implantation of the auxiliary implant needle 23. The first magnetic member can be fixed in the receiving groove 222 by liquid glue, double-sided tape, screws or dimensional tolerance.

[0074] like Figure 3 and Figure 6As shown, the auxiliary needle assembly further includes a cover 21, which is arranged on the end surface of the base 1 through which the plurality of fixing seats 22 are arranged. Since the overall structure of the cover 21 is an L-shaped structure, the cover 21 is also arranged on the adjacent end surface of the base 1 through which the plurality of fixing seats 22 are arranged. The cover 21 can slide relative to the base 1 to cover part of the slots 11 on the base 1. In the case where a first magnetic body 221 is provided at the axial end of each fixing seat 22, a cover 21 is provided on the end surface of the base 1 through which the multiple fixing seats 22 are provided, and the cover 21 slides relative to the base 1 to cover part of the slots 11 on the base 1. With this arrangement, whether the multiple fixing seats 22 are installed in the multiple slots 11 of the base 1 before the implantation operation, or each fixing seat 22 is taken out by the implantation control member during the implantation process, the cover 21 can be used to cover part of the slots 11 or the fixing seats 22 in real time, so as to avoid the first magnetic members on the multiple fixing seats 22 from attracting each other and causing influence, thereby improving the reliability of the implantation process.

[0075] Furthermore, the plurality of slots 11 on the base 1 are arranged in an array along a target direction on the base 1, and the direction in which the cover 21 slides relative to the base 1 is consistent with the target direction. Figure 3 As shown, the dotted line structure in the figure is the cover 21. When the four slots 11 are arranged in an array along the horizontal left-right direction on the base 1, the direction in which the cover 21 slides relative to the base 1 is the horizontal left-right direction. Through this arrangement, when multiple fixing seats 22 are installed on the base 1 or multiple fixing seats 22 are taken out one by one from the base 1, they can be installed or taken out along the sliding direction of the cover 21. In this process, the multiple fixing seats 22 can be gradually covered or detached by sliding the cover 21 along the sliding direction, which more effectively avoids the first magnetic suction parts on adjacent fixing seats 22 from attracting each other, and is more convenient to operate. However, it should be noted that in other alternative embodiments, the arrangement of the multiple slots 11 on the base 1 may not be arranged in an array along the target direction, and the direction in which the cover 21 slides relative to the base 1 may not be consistent with the target direction. Both can be adjusted according to actual needs without fixed restrictions.

[0076] In addition, if Figure 4-Figure 6As shown, in order to cooperate with the sliding and fixing of the cover 21 on the base 1, the base 1 is further provided with a guide block 12 on the side wall adjacent to the slot hole 11, and an adjustment hole 13 is further provided on the top wall of the base 1. In order to cooperate with the setting of the guide block 12 and the adjustment hole 13, the cover 21 is respectively provided with a guide groove 212 and a sliding groove 213 on the corresponding side. When the cover 21 is set on the base 1, the guide block 12 is accommodated in the guide groove 212 and can move along the extension direction of the guide groove 212, thereby limiting the movement path of the cover 21 relative to the base 1. At the same time, after the movement is completed, the adjustment screw 211 can be used to pass through the sliding groove 213 on the cover 21 and be connected to the adjustment hole 13 to fix the cover 21 relative to the base 1. In addition, the setting of the guide block 12 and the guide groove 212 can also cause the cover 21 to shake during the sliding process, affecting the stability during the operation. In other alternative embodiments, the cover 21 can slide smoothly by replacing the material of the cover 21 and the matching dimensions of the frame and the base 1.

[0077] like Figure 1 and Fig. 9 As shown, the implant control member in the flexible microelectrode implant device includes, in addition to the third magnetic body 53, an adjustment column 52 and a magnet fixing frame 51. The third magnetic body 53 is connected to the adjustment column 52, and the adjustment column 52 can adjust the position of the third magnetic body 53 to achieve the magnetic attraction of the third magnetic body 53 to the first magnetic body 221 on each fixing seat 22. Through this arrangement, the movement range of the third magnetic body 53 can be increased, and it is more convenient to magnetically attract the first magnetic body 221 on the fixing seat 22. At the same time, it is also convenient to adjust the position of each fixing seat 22 so that it can reach the preset position of the brain area after being separated from the base 1, thereby achieving rapid and accurate implantation. Furthermore, the magnet fixing frame 51 of the implant control member is connected to the end of the adjustment column 52 and can move relative to the adjustment column 52. The third magnetic body 53 is arranged on the magnet fixing frame 51, which further increases the movement flexibility of the third magnetic body 53, and thus is more convenient for mutual magnetic attraction with the first magnetic body 221, thereby driving the fixing seat 22 to reach the preset position of the brain area; at the same time, through the setting of the magnet fixing frame 51, the interference between the adjustment column 52 and the base 1 can also be reduced, thereby avoiding collision during operation and improving the reliability of the implantation process.

[0078] As described above, the flexible microelectrode implantation device in this embodiment includes not only the flexible microelectrode implantation device, but also a fastening mechanism and a control circuit board 7. Figure 1 , Figure 2 and Fig.10As shown, by setting a control circuit board 7, one end of the four flexible microelectrodes 4 are connected to the control circuit board 7, and the other ends of the four flexible microelectrodes 4 are respectively connected to the corresponding auxiliary implant needles 23, so that the control circuit board 7 is used to fix these flexible microelectrodes 4 and output signals. Fig.11 As shown, the fastening mechanism mainly includes a fastening frame 61 and a fastening block 62, and the control circuit board 7 and the fastening block 62 are matched with each other and fixed on the fastening frame 61. The relative position of the control circuit board 7 is positioned and adjusted by the fastening mechanism, so that the control circuit board 7 can be adjusted and positioned as needed during the implantation of the flexible microelectrode 4, and the stability during the implantation of multiple flexible microelectrodes 4 is ensured.

[0079] like Fig.12 and Fig.13 As shown, a first fastening hole 616 is provided on the fastening frame 61 of the fastening mechanism, and a second fastening hole 14 is provided on the base 1 corresponding to the first fastening hole 616. A fastening screw 66 is sequentially passed through and connected to the first fastening hole 616 and the second fastening hole 14 to connect the fastening frame 61 to the base 1. At the same time, the fastening frame 61 also has two fastening parts 611 arranged opposite to each other, and a "U-shaped" space is formed between the two fastening parts 611. The fastening block 62 and the control circuit board 7 are both arranged between the two fastening parts 611, and the fastening block 62 clamps and fixes the control circuit board 7 by adjusting the distance between the fastening block 62 and the adjacent fastening part 611. Through this arrangement, the fastening mechanism is connected to the base 1 of the flexible microelectrode implantation device through the fastening frame 61, so that the fastening mechanism and the flexible microelectrode implantation device can remain relatively fixed, thereby improving the stability of the entire device. At the same time, the fastening block 62 and the control circuit board 7 are both arranged between the two fastening parts 611 of the fastening frame 61. By adjusting the distance between the fastening block 62 and the fastening part 611, the control circuit board 7 is clamped and fixed, which is more convenient to operate. At the same time, the clamping force of the control circuit board 7 can be made more uniform and more stable.

[0080] Specifically, threaded holes 613 and guide holes 617 are correspondingly provided on the fixing block 62 and the fixing part 611 adjacent thereto, and two pin holes 622 are provided on the fixing block 62, and the two pin holes 622 are perpendicular to and connected to the threaded holes 613 on the fixing block 62. The fastening mechanism also includes a modified screw 63, a guide screw 64 and a pin 65, and the two guide screws 64 respectively pass through the corresponding guide holes 617 on the fixing block 62 and the fixing part 611 adjacent thereto, so as to realize the positioning between the fixing block 62 and the fixing part 611. Fig.14As shown, an annular groove 631 is formed at the end of the modified screw 63, and the modified screw 63 passes through the threaded holes 613 on the fixing portion 611 and the fixing block 62 in sequence. The two pins 65 pass through the pin holes 622 respectively and are engaged in the annular groove 631. Through this arrangement, the modified screw 63 in the fastening mechanism is passed through the threaded hole 613 on the fastening portion 611 and the fastening block 62 to achieve preliminary fixation between the fastening frame 61 and the fastening block 62, and then the pin shaft 65 is passed through the pin hole 622 on the fastening block 62 and clamped in the annular groove 631 of the modified screw 63. Since the pin hole 622 on the fastening block 62 is perpendicular to the threaded hole 613, when the modified screw 63 is rotated and screwed in and out, the fastening block 62 can be driven to move relative to the fastening frame 61, and then the distance between the two can be adjusted to achieve clamping and loosening of the control circuit board 7, and the fastening block 62 will not be separated from the fastening frame 61, so the structure is reliable and easy to operate.

[0081] In addition, if Figure 10-13 As shown, the tightening frame 61 and the tightening block 62 are respectively provided with a protrusion 612 and a fixing protrusion 621, so that when the control circuit board 7 is clamped, the protrusion 612 and the fixing protrusion 621 are used to clamp only the non-signal transmission area of ​​the control circuit board 7, avoiding affecting the function of the control circuit board 7. At the same time, the tightening frame 61 and the tightening block 62 are respectively provided with a protrusion 612 and a fixing protrusion 621, which can meet the requirements of positive and negative clamping of the control circuit board 7, avoiding damage to the control circuit board 7 due to wrong installation direction.

[0082] In addition, this embodiment also provides a flexible microelectrode implantation system, which includes the flexible microelectrode implantation device and the positioning device as described above. Figure 1 , Fig. 9 and Fig.11As shown, the flexible microelectrode implantation device includes a fixed column 3 and an adjustment column 52, wherein the adjustment column 52 is connected to the magnet fixing frame 51, and the fixed column 3 is connected to the fixing frame 61, and the fixing frame 61 is provided with a column mounting hole 614 and a fixing screw mounting hole 615. By connecting the end of the fixed column 3 to the column mounting hole 614, and then passing the screw through the fixing screw mounting hole 615 to connect to the end of the fixed column 3, the fixed column 3 can be stably connected to the fixing frame 61. The positioning device is connected to the fixed column 3 and the adjustment column 52 to manipulate the fixed column 3 and the adjustment column 52, thereby realizing the implantation of the auxiliary implantation needle 23 and the flexible microelectrode 4. It should be noted that the positioning device can be a manual device, or an automatic control device existing in the prior art, such as a double-arm brain stereotaxic instrument, to achieve automated implantation. By setting up a positioning device, the fixed column 3 and the adjustment column 52 of the microelectrode implant device are positioned and adjusted, thereby realizing the positioning and adjustment of the implant control member and the fastening mechanism, thereby making it more convenient to control multiple implant needle assemblies 2 and implant control members during the actual implantation process, thereby realizing automatic or manual positioning and adjustment of the microelectrode implant device.

[0083] The entire operation process is briefly described below to facilitate a better understanding of the above content, but this operation process is only an exemplary description and is not an operation process that cannot be changed or improved.

[0084] First, the implant needle assembly 2 formed by the fixing seat 22 and the auxiliary implant needle 23 is fixed in sequence in the control of the base 1. When the implant needle assembly 2 is installed in the slot 11, it is installed in sequence along a fixed direction, for example, from left to right. After each implant needle assembly 2 is installed, the sliding cover 21 covers it to prevent the second implant needle assembly 2 from interfering with the already installed implant needle assembly 2 when the second implant needle assembly 2 is installed, causing the already installed implant needle assembly 2 to be separated from the base 1 or the second implant needle assembly 2 to be inconvenient to install.

[0085] Second, the control circuit board 7 together with the plurality of flexible micro-electrodes 4 are fixed on the fixing frame 61 on the fixing mechanism, and the base 1 is fixed on the side of the fixing frame 61 .

[0086] Third, under a microscope, the ends of the flexible microelectrodes 4 connected to the control circuit board 7 are fixed to the ends of the auxiliary protein needles in sequence.

[0087] Fourth, the fixed column 3 and the adjustment column 52 are fixed on the double-arm brain stereotaxic instrument respectively, and the stereotaxic instrument is adjusted according to the different brain regions to be implanted to reach the vicinity of the corresponding brain region. The first magnetic body 221 on each fixed seat 22 is magnetically attracted by the third magnetic body 53 on the implant control member, and then moved to the implantation brain region for implantation.

[0088] Fifth, the flexible microelectrode 4 is implanted into the brain tissue under the drive of the auxiliary implant needle 23, and the auxiliary implant needle 23 is dissolved by physiological saline, and the implantation and detachment of multiple auxiliary implant needles 23 are completed in sequence. The order in which the third magnetic body 53 magnetically attracts the implant needle assembly 2 is opposite to the order in which the implant needle assembly 2 is installed on the base 1. For example, when the implant needle assembly 2 is installed in the slot 11, it is installed from left to right along the base 1. At this time, the third magnetic body 53 magnetically attracts the implant needle assembly 2 to be removed from the base 1, that is, from right to left along the base 1. When taking out the first implant needle assembly 2, the fixing seat 22 of the adjacent implant needle assembly 2 is covered with a cover 21 to prevent it from being affected by magnetism. After each implantation is completed, the fixing seat 22 can be manually removed to prevent it from being in the waste box.

[0089] Sixth, after all implants are completed, the control circuit board 7 is fixed with dental cement.

[0090] Seventh, rotate the reforming screw 63 to loosen the fixing block 62 to separate it from the control circuit board 7.

[0091] Example 2

[0092] This embodiment also provides a flexible microelectrode implantation device, and a flexible microelectrode implantation apparatus and a flexible microelectrode implantation system comprising the same. The flexible microelectrode implantation device in this embodiment is substantially the same as the flexible microelectrode implantation device in Example 1, and only the differences are described in detail below. The reference numerals in this embodiment may refer to the corresponding reference numerals in Example 1.

[0093] In this embodiment, the implant needle assembly 2 includes a fixed seat 22 and an auxiliary implant needle 23, and the fixed seat 22 is still placed in the slot 11 of the base 1. However, in this embodiment, the direction in which the fixed seat 22 is penetrated relative to the base 1 is the radial direction of the slot 11, that is, each fixed seat 22 is penetrated in one of the slots 11 along the radial direction of the slot 11 through a through opening connected to the slot 11. At the same time, one end of the fixed seat 22 along its axial direction is connected to the auxiliary implant needle 23, and the other end of the fixed seat 22 along its axial direction is not provided with a receiving groove 222, but the fixed seat 22 itself is set as a magnetic body that can be magnetically attracted. The second magnetic member on each fixed seat 22 specifically adopts a second magnetic body, and the second magnetic body is fixedly arranged in each slot 11, that is, the position of the second magnetic body relative to the slot 11 is fixed, and when the fixed seat 22 is placed in the slot 11, it can be magnetically attracted by the second magnetic body and relatively fixed. When the fixing seat 22 needs to be taken out from the slot 11 of the base 1, the third magnetic body 53 of the implanted control member can be directly magnetically attracted to the fixing seat 22 to separate the fixing seat 22 from the corresponding second magnetic body, thereby realizing the removal of the auxiliary implant needle 23 connected to the fixing seat 22 from the slot 11 of the base 1. In addition, a silicone pad is provided between the second magnetic body and the fixing seat 22, and the magnetic attraction of the second magnetic body relative to the fixing seat 22 is adjusted by the silicone pad. The silicone pad can be fixed to the second magnetic body by adhesive or other glue, thereby making it easier for the third magnetic body 53 to magnetically attract the fixing seat 22 and remove it.

[0094] Through this arrangement in the present embodiment, the second magnetic body is fixed in the corresponding slot 11. Even if the cover 21 is not provided, mutual interference between the second magnetic bodies during the installation and removal of the fixing seat 22 can be avoided. The structure is simpler and the operation is more reliable and convenient.

[0095] Further, such as Fig.15 As shown, since the fixing seat 22 in this embodiment directly adopts a magnetic body, and the direction in which the fixing seat 22 is penetrated relative to the base 1 is the radial direction of the slot 11, the auxiliary implantation needle 23 is connected to the lower side of the corresponding fixing seat 22, and the fixing seat 22 is inscribed inward at the position where the auxiliary implantation needle 23 is connected. The depth of the inscription depends on the thickness of the auxiliary implantation needle 23, so that when the auxiliary implantation needle 23 is attached to the fixing seat 22, the outer surface of the fixing seat 22 can be flush, which is convenient for the third magnetic body 53 of the implant control member to be better magnetically attracted to the side of the fixing seat 22; at the same time, this method of magnetic attraction from the side of the fixing seat 22 has a larger contact area, a greater magnetic attraction force, and is easier to maintain stability.

[0096] Example 3

[0097] This embodiment also provides a flexible microelectrode implantation device, and a flexible microelectrode implantation apparatus and a flexible microelectrode implantation system comprising the same. The flexible microelectrode implantation apparatus in this embodiment is substantially the same as the flexible microelectrode implantation apparatus in Example 1, and only the differences are described in detail below. The reference numerals in this embodiment may refer to the corresponding reference numerals in Example 1.

[0098] like Fig.16 and Fig.17 As shown, the fastening mechanism in this embodiment specifically includes a fastening body 67, the material of the fastening body 67 is an elastic material such as polyurethane, and the control circuit board 7 is inserted into the fastening body 67. The fastening body 67 can apply a clamping force to the control circuit board 7 under the action of an external force, so that the control circuit board 7 is fixed relative to the fastening body 67. Specifically, the implantation control component of the flexible microelectrode implantation device directly sets the third magnetic body 53 at the end of the adjustment column 52, so as to directly control the third magnetic body 53 by using the adjustment column 52. Fig.18 As shown, the base 1 of the flexible microelectrode implant device is directly integrated with the fastening body 67 by 3D printing to reduce the number of machined parts, reduce production costs, and facilitate assembly. At the same time, the fastening body 67 of elastic material is in direct contact with the control circuit board 7, which can also reduce damage to the control circuit board 7, and in actual operation, the hardness of polyurethane can be adjusted as needed.

[0099] Specifically, the fixing column 3 is connected to the fastening body 67, and the control circuit board 7 is inserted into the fastening body 67 through the insertion slot 671, and then the second clamping screw 673 outside the fastening body 67 is matched with the first clamping screw 672 inside the fastening body 67 to fix the control circuit board 7. At the same time, a slot 11 is provided on the base 1 integrally provided with the fastening body 67, and the fixing seats 22 of the implant needle assembly 2 are respectively inserted into the slot 11, and the fixing seats 22 are connected to the auxiliary implant needles 23, and the flexible microelectrode 4 connected to the control circuit board 7 is connected to the corresponding auxiliary implant needles 23. The third magnetic body 53 is controlled by the adjustment column 52 to magnetically attract each fixing seat 22, so that it drives the corresponding auxiliary implant needle 23 to detach from the slot 11 of the base 1, so that the corresponding flexible microelectrode 4 is implanted into the preset position of the brain area.

[0100] In addition, if Fig.19As shown, in this embodiment, the auxiliary implantation needle 23 is a tungsten needle, and the auxiliary implantation needle 23 is directly inserted into the fixing seat 22, and the auxiliary implantation needle 23 and the fixing seat 22 are connected by a non-biosoluble glue. Through this arrangement, when each auxiliary implantation needle 23 is used for auxiliary implantation by using the fixing seat 22, the connection between the auxiliary implantation needle 23 and the fixing seat 22 is more tightly connected, so as to avoid the auxiliary implantation needle 23 from being separated from the fixing seat 22 during the implantation process and when the auxiliary implantation needle 23 is taken out by using the fixing seat 22, thereby improving the stability and reliability of the implantation.

[0101] Since the auxiliary implantation needle 23 in this embodiment adopts a tungsten needle, after the flexible microelectrode 4 is implanted with the tungsten needle, the tungsten needle needs to be pulled out. Therefore, the positioning device in the flexible microelectrode implantation system in this embodiment also includes a quick-change part 9 and an electromagnet 8, such as Fig. 20 and Fig.21 As shown, the electromagnet 8 is connected to the main body of the positioning device through a quick-change part 9, and at the same time, the electromagnet 8 is used to connect to the adjustment column 52 of the implant control part, and the electromagnet 8 drives the implant control part to move through electromagnetic attraction and disconnection. By arranging the electromagnet 8 on the positioning device, and using the electromagnet 8 to connect to the adjustment column 52 of the implant control part, the implant control part can be driven to move quickly through electromagnetic attraction and disconnection, which is more convenient for implanting the auxiliary implant needle 23 and the flexible microelectrode 4. At the same time, when the auxiliary implant needle 23 needs to be pulled out, it can also be operated quickly to avoid the auxiliary implant needle 23 causing secondary damage to the brain tissue during the extraction process. However, it should be noted that in other alternative embodiments, even if the auxiliary implant needle 23 is a silk protein needle, the electromagnet 8 and the quick-change part 9 can be set in the positioning device to achieve the rapid implantation of the flexible microelectrode 4 driven by the auxiliary implant needle 23.

[0102] Example 4

[0103] This embodiment also provides a flexible microelectrode implantation device, and a flexible microelectrode implantation apparatus and a flexible microelectrode implantation system comprising the same. The flexible microelectrode implantation apparatus in this embodiment is substantially the same as the flexible microelectrode implantation apparatus in Example 3, and only the differences are described in detail below. The reference numerals in this embodiment may refer to the corresponding reference numerals in Example 1.

[0104] like Fig. 22 , Fig.23 and Fig.24As shown, in this embodiment, the fastening mechanism 6 specifically includes a fastening body 67, which is an integral structure, and the fixed column 3 is connected to one end face of the fastening body 67 in the axial direction. The control circuit board 7 is inserted and fixed in the fastening body 67 along the other end face of the fastening body 67 in the axial direction, and the end of the control circuit board 7 extending out of the fastening body 67 is connected to a plurality of flexible microelectrodes 4. Four slots are provided on the side wall of the fastening body 67, and the four fixing seats 22 corresponding to the implant needle assembly 2 are respectively placed in the corresponding slots along the radial direction of the fastening body 67, that is, the fixing seat 22 can be moved from the side of the fastening body 67. When the fixing seat 22 is placed in the slot, it can be fixed with an adhesive with suitable viscosity to prevent the fixing seat 22 from easily detaching from the fastening body 67. In addition, the fastening body 67 has an opening for the auxiliary protein needle 23 to move in or out in each corresponding slot, and each fixing seat 22 is connected to the auxiliary protein needle 23, and drives the auxiliary protein needle 23 to move synchronously. The flexible microelectrodes 4 connected to the control circuit board 7 are respectively connected to auxiliary protein needles 23. When the fixing seat 22 is moved and separated from the fastening body 67 by the magnetic body, the auxiliary protein needles 23 on the fixing seat 22 can drive the flexible microelectrode 4 to move and be implanted into the preset position of the brain area according to the operator's control. In addition, this kind of structural collective setting makes the overall structure more compact and more convenient to operate.

[0105] The embodiments of the present application have been described above, and the above description is exemplary, not exhaustive, and is not limited to the disclosed embodiments. Many modifications and changes will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The selection of terms used herein is intended to best explain the principles of the embodiments, practical applications, or improvements to the technology in the market, or to enable other persons of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

1. A flexible microelectrode implantation device, characterized in that: It comprises a base (1), a plurality of implantation needle assemblies (2), a plurality of flexible microelectrodes (4) and an implantation control member; Each of the implant needle assemblies (2) comprises a fixing seat (22) and an auxiliary implant needle (23) which are connected to each other, and the fixing seats (22) of the implant needle assemblies (2) can be detachably connected to the base (1), and the auxiliary implant needle (23) of each of the implant needle assemblies (2) is respectively connected to one of the flexible microelectrodes (4); The implant control component includes a first magnetic component, and each of the fixing seats (22) includes a second magnetic component. The implant control component is magnetically attracted to the second magnetic component on each of the fixing seats (22) through the first magnetic component, thereby driving each of the fixing seats (22) and the corresponding auxiliary implant needle (23) to be detached from the base (1), thereby achieving the implantation of the corresponding flexible microelectrode (4) into a preset position in the brain area.

2. The flexible microelectrode implantation device according to claim 1, characterized in that: The auxiliary implantation needle (23) is a silk protein needle, and the auxiliary implantation needle (23) is connected to the fixing seat (22) via a biosoluble glue; Alternatively, the auxiliary implantation needle (23) is a tungsten needle, and the auxiliary implantation needle (23) is connected to the fixing seat (22) via a non-biosoluble glue.

3. The flexible microelectrode implantation device according to claim 1, characterized in that: The base (1) is provided with a plurality of slots (11), and the side wall of the base (1) is provided with a plurality of through openings connected to each of the slots (11); each of the fixing seats (22) is inserted into one of the slots (11) along a preset direction, and the implant control member drives each of the fixing seats (22) to detach from the corresponding slot (11) along the preset direction.

4. The flexible microelectrode implantation device according to claim 3, characterized in that: The preset direction is the axial direction of the slot hole (11), and in the axial direction of the slot hole (11), one end of each of the fixing seats (22) is connected to the auxiliary implantation needle (23), and the other end of each of the fixing seats (22) is provided with a receiving groove (222); The second magnetic component is a first magnetic body (221), and the first magnetic body (221) is fixedly arranged in the receiving groove (222) corresponding to the fixing seat (22), and the implant control component is magnetically attracted to the fixing seat (22) through the first magnetic body (221).

5. The flexible microelectrode implantation device according to claim 4, characterized in that: The implant needle assembly (2) further comprises a cover (21), wherein the cover (21) is arranged on the end surface of the base (1) through which the plurality of fixing seats (22) are arranged, and the cover (21) can slide relative to the base (1) to cover part of the slot holes (11) on the base (1).

6. The flexible microelectrode implantation device according to claim 5, characterized in that: The plurality of slots (11) are arranged in an array along a target direction on the base (1), and the direction in which the cover (21) slides relative to the base (1) is consistent with the target direction.

7. The flexible microelectrode implantation device according to claim 3, characterized in that: Each of the fixing seats (22) is a magnetic body, and each of the fixing seats (22) is arranged in one of the slot holes (11) through the through opening along the radial direction of the slot hole (11); The second magnetic member is a second magnetic body, and the second magnetic body is fixedly arranged inside each of the slot holes (11). In the axial direction of the slot holes (11), one end of each of the fixing seats (22) is connected to the auxiliary implant needle (23), and the other end of each of the fixing seats (22) is magnetically attracted to the second magnetic body in the corresponding slot hole (11).

8. The flexible microelectrode implantation device according to any one of claims 1 to 7, characterized in that: The implant control component also includes an adjustment column (52), the first magnetic component is a third magnetic body (53), the third magnetic body (53) is connected to the adjustment column (52), and the adjustment column (52) can adjust the position of the third magnetic body (53) to achieve the magnetic attraction of the third magnetic body (53) to the second magnetic component on each of the fixing seats (22).

9. The flexible microelectrode implantation device according to claim 8, characterized in that: The implant manipulation component also includes a magnet fixing frame (51), the magnet fixing frame (51) is connected to the end of the adjustment column (52) and can move relative to the adjustment column (52), and the third magnetic body (53) is arranged on the magnet fixing frame (51).

10. A flexible microelectrode implantation device, characterized in that: It includes: The flexible microelectrode implantation device according to any one of claims 1 to 9; A control circuit board (7), one end of each of the plurality of flexible microelectrodes (4) is connected to the control circuit board (7), and the other ends of each of the plurality of flexible microelectrodes (4) are respectively connected to the corresponding auxiliary implantation needles (23); A fastening mechanism, the fastening mechanism is used to position and adjust the relative position of the control circuit board (7).

11. The flexible microelectrode implantation device according to claim 10, characterized in that: The fastening mechanism comprises: A fastening frame (61), wherein the fastening mechanism is connected to the base (1) of the flexible microelectrode (4) implantation device via the fastening frame (61), and the fastening frame (61) has two fastening parts arranged opposite to each other; A tightening block (62), wherein the tightening block (62) and the control circuit board (7) are both arranged between the two tightening portions, and the tightening block (62) can achieve clamping and fixing of the control circuit board (7) by adjusting the distance between the tightening block (62) and the adjacent tightening portions.

12. The flexible microelectrode implantation device according to claim 11, characterized in that: The fixing block (62) and the fixing portion adjacent thereto are provided with threaded holes (613) correspondingly, and the fixing block (62) is also provided with a pin hole (622), and the pin hole (622) is perpendicular to and communicated with the threaded hole (613) on the fixing block (62); The fastening mechanism also includes a modified screw (63) and a pin shaft (65). The modified screw (63) is provided with an annular groove (631). The modified screw (63) passes through the threaded holes (613) on the fastening portion and the fixing block (62) in sequence. The pin shaft (65) passes through the pin hole (622) and is engaged in the annular groove (631).

13. The flexible microelectrode implantation device according to claim 11, characterized in that: The fastening mechanism comprises a fastening body (67), the control circuit board (7) is inserted into the interior of the fastening body (67), the fastening body (67) is made of elastic material and can apply a clamping force to the control circuit board (7) under the action of an external force.

14. The flexible microelectrode implantation device according to claim 13, characterized in that: The fastening body (67) and the base (1) are integrally formed by 3D printing.

15. A flexible microelectrode implantation system, characterized in that: These include: The flexible microelectrode implantation device according to any one of claims 10 to 14; A positioning device is connected to the implantation control member and the fastening mechanism of the flexible microelectrode implantation device, and can perform positioning and adjustment on the implantation control member and the fastening mechanism.

16. The flexible microelectrode implantation system according to claim 15, characterized in that: The positioning device comprises an electromagnet (8), and the positioning device is connected to the implant control member via the electromagnet (8). The electromagnet (8) drives the implant control member to move by electromagnetic attraction and disconnection.

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