Difluorobenzenesulfonyl morroniside derivative as well as synthesis method and application thereof

Abstract

The invention belongs to the technical field of organic chemistry and organic compound synthesis, and particularly relates to a difluoro benzene sulfonyl morroniside derivative and a synthesis method and application thereof. The derivative has a structure as shown in the specification, and the difluorobenzene sulfonyl morroniside derivative with a novel structure is synthesized by taking morroniside and 2, 5-difluorobenzene sulfonyl chloride as raw materials and carrying out esterification reaction under the catalysis of a catalyst DMAP (Dimethylaminopyridine) and regulating and controlling reaction conditions. The synthesis method has the advantages of easily available raw materials, simple steps and high product purity, and is suitable for industrial production. Moreover, according to a DPPH free radical scavenging experiment, an ABTS free radical scavenging experiment, an iron ion reduction antioxidant capacity determination, a superoxide anion free radical scavenging experiment and a PC12 cell experiment, the antioxidant capacity of the difluorobenzenesulfonyl morroniside derivative is superior to that of morroniside; the compound can be used as a novel antioxidant for deep development and application in the fields of medicine, health care products and food, and has a good application prospect. # imgabs0 #

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