Beauty composition and application thereof

Abstract

The invention discloses a beautifying composition and application thereof. The beautifying composition is prepared from camphane glycol and dandelion extract. The composition can play a very good synergistic effect in the aspect of improving skin microcirculation, so that the dosage of camphanediol can be reduced, and the aims of low cost, high efficacy and high safety are achieved.

Description

Technical Field

[0001] The invention relates to a cosmetic composition and application thereof, belonging to the technical field of cosmetics. Background Art

[0002] Skin microcirculation is a system that participates in the exchange of substances, energy, and biological information between cells and tissues, and capillaries are the basis for achieving microcirculation. The capillary network of the skin is a complex power system that plays a very important role in skin color, temperature regulation, skin metabolism, and transdermal transport. In the facial skin, the density of nerve fibers and capillaries around the eyes is high, and they are significantly affected by blood circulation. Damage to the microcirculation around the eyes can easily lead to vascular dark circles and edema-type eye bags. In addition, aging, irregular living habits, lack of exercise, smoking, alcoholism, etc. will slow down blood circulation, making it easier to have aesthetic defects or discomfort such as local edema, pale complexion, dark circles, redness / itching of the skin, etc.

[0003] WO2011097617A2 discloses a composition for reducing dark circles, which comprises at least one bicyclic monoterpene diol and at least one skin lightening agent, wherein the bicyclic monoterpene diol comprises camphanediol. The prior art claims that the combination of the two achieves a synergistic effect of reducing dark circles, but the effect is not actually verified, nor is there any content on obtaining a better effect by targeting skin microcirculation.

[0004] In addition, since camphanediol is very expensive, its practical application is limited. How to better improve skin microcirculation at a low dosage of camphanediol is still a technical problem to be solved. Summary of the invention

[0005] After extensive research, the inventors found that the combined use of camphanediol and dandelion extract can play a good synergistic role in improving skin microcirculation, thereby solving the above technical problems.

[0006] The present invention has the following technical solutions:

[0007] A cosmetic composition comprises camphanediol and dandelion extract in a physiologically acceptable medium, wherein the mass ratio of the camphanediol to the dandelion extract is 1:0.1-1:30.

[0008] Furthermore, the concentration of camphanediol in the cosmetic composition is 0.0001-1 wt %.

[0009] Furthermore, the concentration of the dandelion extract in the cosmetic composition is 0.0001-1 wt %.

[0010] The present invention also provides application of the cosmetic composition in improving skin microcirculation.

[0011] The present invention also provides application of the cosmetic composition in promoting skin blood circulation.

[0012] The present invention also provides the use of the cosmetic composition in preventing and / or improving skin redness and / or skin itching and / or skin edema and / or dark circles and / or edema-type eye bags caused by skin blood vessels.

[0013] The present invention also provides application of the cosmetic composition in preparing cosmetics.

[0014] The present invention also provides a method for improving skin microcirculation, the method comprising applying the above cosmetic composition on the skin. The method of the present invention is for non-therapeutic purposes and can be used for human beauty.

[0015] The present invention has the following beneficial effects:

[0016] The present invention shows a synergistic effect in improving skin microcirculation after compounding camphanediol and dandelion extract, thereby the amount of camphanediol used can be well reduced, the cost is reduced, and the efficacy will not be reduced. The present invention has a good application prospect in cosmetics for improving skin microcirculation, promoting skin blood circulation, preventing and / or improving skin redness, skin itching, skin edema and / or dark circles and / or edema-type eye bags caused by skin blood vessels, etc. DETAILED DESCRIPTION

[0017] The following is a description of exemplary embodiments of the present invention, including various details of the embodiments of the present invention to aid understanding, which should be considered as merely exemplary. Therefore, it should be appreciated by those of ordinary skill in the art that various changes and modifications may be made to the embodiments described herein without departing from the scope and spirit of the present invention. Likewise, for clarity and simplicity, descriptions of well-known functions and structures are omitted in the following description.

[0018] Unless otherwise defined, the technical and scientific terms in this specification have the same meaning as those commonly understood by those skilled in the art. Although similar or identical methods and materials as those described herein may be used in experiments or practical applications, the present invention still describes the materials and methods below. In the event of a conflict, the present specification, including definitions, shall prevail.

[0019] The present invention relates to a composition, and the "composition" can achieve the effects of the present invention, and the "composition" includes but is not limited to using the components simultaneously or sequentially. The "simultaneous use" includes using them together in the same preparation or using them separately in different preparations. The "sequential use" includes using them sequentially in different preparations, and there is no restriction on the order of sequential use.

[0020] The present invention provides a cosmetic composition, wherein the effective ingredients of the composition include camphanediol and dandelion extract. The dandelion extract and camphanediol have a synergistic effect, can significantly increase blood flow velocity, improve skin microcirculation, and thus alleviate skin problems such as redness, itching, edema, dark circles, eye bags, etc. The use of this composition can reduce the amount of camphanediol used, and achieve the goals of low cost, high efficacy, and high safety.

[0021] In the experiment, it was found that when the mass ratio of camphanediol to dandelion extract was 1:0.1-1:30, the two showed obvious synergistic effect, for example, 1:0.1, 1:0.2, 1:0.3, 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8, 1:0.9, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:21, 1:22, 1:23, 1:24, 1:25, 1:26, 1:27, 1:28, 1:29, 1:30.

[0022] In a specific embodiment of the present invention, the mass percentage concentration of camphanediol in the cosmetic composition is 0.0001-1%, for example, 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.0015%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.0015%, 0.002%, 0.003%, 0.004%, 0.005%, 0.006%, 0.006%, 0.007 ... %, 0.002%, 0.0025%, 0.003%, 0.0035%, 0.004%, 0.0045%, 0.005%, 0.0055%, 0.006%, 0.0065%, 0.007%, 0.0075%, 0.008%, 0.0085%, 0.009%, 0.0095%, 0.01%, 0. 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, 0.20%, 0.21%, 0.22%, 0.23%, 0.24%, 0.25%, 0.26%, 0.27%, 0.28%, 0.29%, 0.30%, 0.35%, 0.40%, 0.45%, 0.50%, 0.55%, 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, 0.95%, 1.0%, and any range therebetween.

[0023] In a specific embodiment of the present invention, the mass percentage concentration of dandelion extract in the cosmetic composition is 0.0001-1%, for example, 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%, 0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.001%, 0.0015%, 0.002%, 0.0025%, 0.003%, 0.0035%, 0.004%, 0.0045%, 0.005%, 0.0055%, 0.006%, 0.0065%, 0.007%, 0.0075%, 0.008%, 0.0085%, 0.009%, 0.001%, 0.0015%, 0.002%, 0.0025%, 0.003%, 0.0035%, 0.004%, 0.0045%, 0.005%, 0.0055%, 0.006%, 0.0065%, 0.007%, 0.0075%, 0.008%, 0.0085%, 0.009%, 0.0095%, 0.01%, 0.010%, 0.011%, 0.012%, 0.013%, 0.014%, 0.015%, 0.016%, 0.017%, 0.018%, 0.019%, 0.020%, .02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, 0.20%, 0.21%, 0.22%, 0.23%, 0.24%, 0.25%, 0.26%, 0.27%, 0.28%, 0.29%, 0.30%, 0.35%, 0.40%, 0.45%, 0.50%, 0.55%, 0.60%, 0.65%, 0.70%, 0.75%, 0.80%, 0.85%, 0.90%, 0.95%, 1.0%, and any range therebetween.

[0024] The camphanediol used in the present invention has a CAS number of 56614-57-4, a serial number of 04090 in the "Catalogue of Used Cosmetic Raw Materials (2015 Edition)" in China, and an English INCI name of CAMPHANEDIOL.

[0025] The dandelion extract used in the present invention is extracted from the whole dandelion plant as raw material, and the dandelion extract can be in a solid state or a liquid state. The dandelion extract used in the present invention can be commercially available or extracted by a preparation method disclosed in the prior art.

[0026] In a specific embodiment of the present invention, the dandelion extract used in the present invention is obtained by water extraction using the whole dandelion plant as raw material.

[0027] In a specific embodiment of the present invention, the dandelion extract used in the present invention is obtained by extracting the whole dandelion plant with water as raw material.

[0028] In a specific embodiment of the present invention, the dandelion extract used in the present invention is extracted with water from the whole dandelion plant as raw material, and then processed through one, two or three steps of filtering, concentrating, drying, etc. to obtain the extract.

[0029] In a specific embodiment of the present invention, the extraction temperature during water extraction is 80-100°C, such as 85°C, 86°C, 87°C, 88°C, 89°C, 90°C, 91°C, 92°C, 93°C, 94°C, 95°C, 96°C, 97°C, 98°C, 99°C, 100°C. The extraction time can be 0.5-5h, such as 0.5h, 1h, 1.5h, 2h, 2.5h, 3h, 3.5h, 4h, 4.5h, 5h. The amount of water used and the number of extractions can be selected with reference to the decoction method and water extraction method of traditional Chinese medicine disclosed in the prior art.

[0030] In a specific embodiment of the present invention, the cosmetic composition may include, in addition to camphanediol and dandelion extract, other cosmetic active agents in a physiologically acceptable medium to provide multiple skin care benefits.

[0031] The physiologically acceptable medium may be selected from oils, solvents, cosolvents, surfactants, thickeners, rheological agents, buffers, preservatives, pH regulators, fragrances, pigments, etc., or mixtures thereof.

[0032] As cosmetic active agents, they can be selected from the following substances:

[0033] - agents that stimulate skin firmness, such as peptides that stimulate collagen synthesis (type I, III or VII collagen), GABA, oat extracts, ginsenosides or notoginsenosides;

[0034] - agents that condition the pores and sebum, such as rice ferment filtrate, salicylic acid, capryloylsalicylic acid, retinoids, zinc salts, vitamin B6 or pyridoxine;

[0035] --Agents designed to combat pigmentation, such as kojic acid, extracts of blackberry or licorice, arbutin, phenylethylresorcinol;

[0036] - Agents for protection against UV radiation, such as physical sunscreens, chemical sunscreens;

[0037] - agents for protection against free radicals or anti-inflammatory agents, such as extracts of Artemisia capillaris, extracts of Sanguisorba officinalis, resveratrol and its derivatives, turmeric or curcumin or tetrahydrocurcumin, polyphenols extracted from grape seeds, tocopherol and its esters (for example tocopheryl acetate), BHT, BHA, ergothioneine or its derivatives, or idebenone;

[0038] - agents for improving blood circulation in the skin, such as tocopheryl nicotinate, niacinamide, or C-glycoside derivatives (especially C-xylosyl), caffeine, etc.;

[0039] and any mixture of the above substances.

[0040] The preparation method of the above cosmetic composition is not particularly limited, and the components can be mixed evenly. The mixing method and order of the components are not limited.

[0041] The present invention also provides the use of the above cosmetic composition in improving skin microcirculation, and the application mode thereof can be used as a raw material in preparing a product for improving skin microcirculation.

[0042] The present invention also provides the use of the above-mentioned cosmetic composition in promoting skin blood circulation, and the application mode thereof can be used as a raw material in preparing a product that promotes skin blood circulation.

[0043] The present invention also provides the use of the above-mentioned cosmetic composition in preventing and / or improving skin redness and erythema originating from skin blood vessels, and the application mode thereof can be used as a raw material in preparing a product for preventing and / or improving skin redness and erythema.

[0044] The present invention also provides the use of the above cosmetic composition in preventing and / or improving skin itching originating from skin blood vessels, and the application mode thereof can be used as a raw material in preparing a product for preventing and / or improving skin itching.

[0045] The present invention also provides the use of the above cosmetic composition in preventing and / or improving skin edema originating from skin blood vessels, and the application mode thereof can be used as a raw material in preparing a product for preventing and / or improving skin edema.

[0046] The present invention also provides the use of the above cosmetic composition in preventing and / or improving dark circles of skin blood vessel origin, and the application mode can be used as a raw material in preparing products for preventing and / or improving dark circles.

[0047] The present invention also provides the use of the above-mentioned cosmetic composition in preventing and / or improving eye bags caused by skin blood vessels, and the application mode thereof can be used as a raw material in preparing products for preventing and / or improving eye bags caused by skin blood vessels.

[0048] The present invention also provides application of the cosmetic composition in preparing cosmetics.

[0049] In a specific embodiment of the present invention, the cosmetic is a cosmetic having the effect of improving skin microcirculation.

[0050] In a specific embodiment of the present invention, the cosmetic is a cosmetic having the effect of promoting skin blood circulation.

[0051] In a specific embodiment of the present invention, the cosmetic is a cosmetic having the effect of preventing and / or improving skin redness.

[0052] In a specific embodiment of the present invention, the cosmetic is a cosmetic having the effect of preventing and / or improving skin itching.

[0053] In a specific embodiment of the present invention, the cosmetic is a cosmetic having the effect of preventing and / or improving skin edema.

[0054] In a specific embodiment of the present invention, the cosmetic is a cosmetic having the effect of preventing and / or improving dark circles.

[0055] In a specific embodiment of the present invention, the cosmetic is a cosmetic having the effect of preventing and / or improving edema-type eye bags.

[0056] The present invention also provides a cosmetic comprising the above cosmetic composition.

[0057] The present invention also provides a method for improving skin microcirculation, the method comprising applying the above cosmetic composition or the above cosmetics on the skin. The method is a cosmetic method and does not have the purpose of treating diseases.

[0058] Experimental verification

[0059] The efficacy of the present invention is verified by several specific examples and comparative examples. In the following experiments, unless otherwise specified, the concentrations are all mass percentage concentrations, and the reagents or instruments without indicating the manufacturer are all conventional reagent products that can be purchased commercially.

[0060] In the following experiments, the raw materials used are as follows:

[0061]

[0062] Example

[0063] Camphanediol, DF464 dandelion extract and water were mixed to prepare a series of compositions. The contents of camphanediol and dandelion extract in each composition are shown in Table 1.

[0064] Comparative Example

[0065] The components shown in Table 1 were mixed with water to prepare a series of compositions.

[0066] Table 1

[0067]

[0068]

[0069] Note: In Table 1 above, dandelion extract refers to the dandelion extract contained in dandelion extract, and salvia miltiorrhiza extract refers to the salvia miltiorrhiza extract contained in salvia miltiorrhiza extract.

[0070] Test Case

[0071] The effects of different test samples on the blood flow velocity of zebrafish intersegmental vessels were tested.

[0072] 1. Materials

[0073] Standard dilution water, 6-well plates, zebrafish larvae.

[0074] 2. Test samples

[0075] Compositions prepared in Examples and Comparative Examples.

[0076] 3. Experimental methods

[0077] 3.1 Principle

[0078] Microcirculation refers to the blood circulation between arterioles and venules. The blood flow velocity of the zebrafish can be detected by using a heartbeat blood flow analysis system (ZebraBlood 3.4, ViewPoint Life Sciences, France), and the improvement of microcirculation can be analyzed to evaluate whether the sample has the effect of improving microcirculation.

[0079] 3.2 Experimental method

[0080] 1) Before the experiment, pretreat the 6-well plate with standard dilution water, 3 mL / well.

[0081] 2) Fifteen 2 dpf zebrafish larvae of the same developmental stage were used in each well for testing.

[0082] 3) Experimental group: The compositions prepared in the examples and comparative examples were added into the wells of the experimental group as test samples, 3 mL / well.

[0083] 4) Normal control group: Add standard dilution water to the wells of the normal control group, 3 mL / well.

[0084] 3.3 Observation

[0085] 1) The experiment ends at 24h after the addition of each test sample.

[0086] 2) At the end of the experiment, 10 zebrafish were randomly selected from each experimental group, and the zebrafish intersegmental blood flow video was recorded under the heartbeat blood flow analysis system to analyze the zebrafish intersegmental blood flow velocity (V).

[0087] 4. Statistical analysis of results

[0088] 4.1 The microcirculation improvement rate is calculated according to the following formula:

[0089]

[0090] Among them, V(experimental group) is the average blood flow velocity of intersegmental vessels of zebrafish in the experimental group;

[0091] V(normal control group) is the average blood flow velocity of intersegmental vessels of zebrafish in the normal control group.

[0092] 4.2 Statistical analysis

[0093] Student's t test was used to perform statistical analysis on the blood flow velocity of zebrafish intersegmental vessels. When the blood flow velocity of zebrafish intersegmental vessels in the experimental group was compared with that in the normal control group, p≤0.05 was considered significant, p≤0.01 was considered very significant, and p≤0.005 was considered highly significant.

[0094] 4.3 Criteria for judging synergy:

[0095] When the actual microcirculation improvement rate (Eactual) after treatment with the combination is significantly greater than Etheoretical, it is synergistic;

[0096] When the actual microcirculation improvement rate (Eactual) after treatment with the composition is significantly less than Etheoretical, it is antagonistic;

[0097] When the actual microcirculation improvement rate after treatment with the composition (Eactual) = Etheoretical, it is additive.

[0098] The theoretical calculation formula of E is as follows:

[0099] Etheory = (X + YX * Y) / 100

[0100] In the above formula, X and Y are the microcirculation improvement rates when a single component is used alone.

[0101] 5. Experimental results

[0102] The effects of the samples of various embodiments and comparative examples on the blood flow velocity of zebrafish intersegmental vessels are shown in Table 2 below.

[0103] Table 2

[0104]

[0105]

[0106] From the data in Table 2, it can be seen that when camphanediol and dandelion extract are used in combination in a certain proportion, they show obvious synergistic effects. On the basis of using a lower content of active ingredients, it can promote skin blood circulation and achieve a higher effect of improving skin microcirculation, which is beneficial to reduce the use of high-cost camphanediol and reduce production costs.

[0107] Although the embodiments of the present invention are described above, the present invention is not limited to the above specific embodiments and application fields, and the above specific embodiments are only illustrative and instructive, but not restrictive. A person skilled in the art can make many forms under the guidance of this specification and without departing from the scope of protection of the claims of the present invention, all of which belong to the protection of the present invention.

Claims

1. A cosmetic composition, characterized in that: The physiologically acceptable medium comprises camphanediol and dandelion extract, wherein the mass ratio of the camphanediol to the dandelion extract is 1:0.1-1:

30.

2. The cosmetic composition according to claim 1, characterized in that: The concentration of camphanediol in the cosmetic composition is 0.0001-1 wt%.

3. The cosmetic composition according to claim 1, characterized in that: The concentration of dandelion extract in the cosmetic composition is 0.0001-1 wt %.

4. Use of the cosmetic composition according to any one of claims 1 to 3 in improving skin microcirculation.

5. Use of the cosmetic composition according to any one of claims 1 to 3 in promoting skin blood circulation.

6. Use of the cosmetic composition according to any one of claims 1 to 3 for preventing and / or improving skin redness and / or skin itching and / or skin edema and / or dark circles and / or edematous eye bags of skin vascular origin.

7. Use of the cosmetic composition according to any one of claims 1 to 3 in the preparation of cosmetics.

8. A method for improving skin microcirculation, the method comprising applying the cosmetic composition according to any one of claims 1 to 3 to the skin.

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