Electrode sheet, tumor electric field therapy system, and temperature detection and signal control method

Abstract

The present application provides an electrode sheet, a tumor electric field therapy system, and a temperature detection and signal control method. The electrode sheet includes a flexible circuit board, a plurality of electrode units disposed on the flexible circuit board, and a handshake chip. The plurality of electrode units are divided into a plurality of row groups and a plurality of column groups on the circuit. The flexible circuit board is embedded with multiple conductive traces, which include multiple ground lines corresponding one-to-one to each row group, multiple dual-purpose signal lines corresponding one-to-one to each column group, a communication line connected to a corresponding portion of the handshake chip, and a ground trace for grounding the handshake chip. The ground lines are short-circuited to ground each electrode unit in the corresponding row group. The dual-purpose signal lines transmit an alternating current signal to each electrode unit in a first mode and transmit a direct current signal to each electrode unit in a second mode for temperature signal acquisition.

Description

Technical Field

[0001] The present application relates to Tumor Treating Fields (TTF) technology, and in particular to an electrode sheet, a tumor treating field system, and a temperature detection and signal control method. Background Art

[0002] Tumor electric field therapy is a method of treating tumors by using low-intensity, medium- and high-frequency alternating electric fields to prevent the formation of spindle microtubules during mitosis in certain tumor cells, inhibit the separation of intracellular organelles during cell division, and induce apoptosis in cells during mitosis.

[0003] Compared with traditional cancer treatments, TTF has an innovative mechanism of action. Some physiological characteristics of tumor cells, such as geometric shape and high-frequency mitosis, make them susceptible to TTF. TTF disrupts the normal aggregation of tubulin by exerting directional forces on polar particles (such as macromolecules and organelles) in cells. These processes may lead to physical damage to the cell membrane and cell apoptosis. At the end of cell mitosis, the structural morphology of the cleavage furrow will lead to uneven distribution of the electric field around it. At the same time, under the influence of TTF, the electric field intensity at the cleavage furrow is significantly enhanced, and the charged substances in the cell move toward the cleavage furrow, which interferes with or even destroys the formation of the cell structure, and ultimately leads to cell division failure and apoptosis.

[0004] In existing tumor therapy field systems, an electric field generator transmits the alternating current (AC) signal for tumor therapy to electrodes, which then apply an alternating electric field to the patient's tumor. When the tumor therapy field is applied to the patient's body, heat accumulates at the application site, causing the temperature to rise accordingly. Therefore, the temperature at the application site must be monitored. If the temperature is too high, the electric field intensity must be adjusted promptly to avoid the risk of skin burns caused by excessive heat.

[0005] The tumor electric field therapy system includes at least one pair of electrode sheets, each of which contains multiple electrode units. Even if the same alternating current signal is applied to each electrode unit, the heat generated by each electrode unit will vary due to its different position, that is, the temperature of each electrode unit on the entire electrode sheet will not be completely consistent. In this way, it is possible that the temperature of some electrode units in the entire electrode sheet exceeds the preset temperature, while the temperature of other electrode units is normal. In order to ensure that the tumor electric field therapy has a sufficiently long application time while avoiding low-temperature burns on the patient's body surface, it is necessary to implement individual control of the overheated electrode units. However, for existing electrode sheets, implementing individual control of the electrode units requires providing a conductive trace for each electrode unit in the substrate of the electrode sheet. This will increase the number of conductive traces in the electrode sheet substrate, making the electrode sheet difficult to bend, and the cable electrically connected to the electrode sheet will also be thickened, which increases the overall weight of the electrode sheet, which is not conducive to the application of the electrode sheet.

[0006] Therefore, it is necessary to provide an electrode sheet, a tumor electric field therapy system, a temperature detection method, and a signal application method that use fewer conductive traces to perform partitioned control on multiple electrode units. Summary of the Invention

[0007] The first object of the present application is to provide an electrode sheet to solve or eliminate the problems in the related art.

[0008] The second object of this application is to provide a tumor electric field treatment system.

[0009] The third object of this application is to provide a temperature detection method.

[0010] The fourth object of this application is to provide a signal control method for tumor electric field therapy.

[0011] To achieve the above-mentioned purpose, the present application provides the following technical solutions: an electrode sheet for a tumor electric field therapy system, comprising: a plurality of electrode units, wherein the plurality of electrode units are divided into a plurality of row groups and a plurality of column groups in circuit connection and are arranged in at least two row groups or three column groups in circuit connection; and a handshake chip, wherein the handshake chip is configured to determine the connection status of the electrode sheet through handshake communication; and a flexible circuit board, which is configured for the handshake chip and the plurality of electrode units to be arranged thereon at intervals, and wherein a plurality of conductive traces are embedded in the flexible circuit board, and the plurality of conductive traces include: a plurality of ground wires, which correspond one to one with the plurality of row groups, each corresponding to a plurality of ground wires. The grounding lines are all configured to short-circuit the corresponding parts of each electrode unit in the corresponding row group to ground; and multiple dual-purpose signal lines correspond to the multiple column groups one by one, and each of the dual-purpose signal lines is configured to: transmit AC signals to each electrode unit in the corresponding column group in a first mode, and transmit DC signals or temperature detection signals detected by each electrode unit in the corresponding column group in a second mode; and ground traces, which are configured to ground the handshake chip; and communication lines, which are electrically connected to the corresponding parts of the handshake chip.

[0012] Furthermore, the number of the dual-purpose signal lines is related to the number of the column groups into which the electrode units are divided, and the number of the ground lines is related to the number of the row groups into which the electrode units are divided.

[0013] Furthermore, the number of the dual-purpose signal lines is equal to the number of column groups into which the electrode units are divided.

[0014] Furthermore, the number of the grounding lines is equal to the number of the row groups into which the electrode units are divided.

[0015] Furthermore, each of the electrode units includes a dielectric element for transmitting an alternating current signal and a temperature sensor having a signal terminal and a ground terminal, and the temperature sensor is used to detect the temperature of the corresponding electrode unit.

[0016] Furthermore, the dielectric element of each electrode unit is short-circuited with the signal end of the temperature sensor.

[0017] Furthermore, each of the electrode units further includes a diode connected in series with the temperature sensor, and the temperature sensor is grounded via the diode connected in series with the temperature sensor.

[0018] Furthermore, the dielectric elements of the plurality of electrode units in the same column group are connected in parallel to the same dual-purpose signal line of the flexible circuit board, the dielectric elements of the plurality of electrode units in different column groups are connected in parallel through different dual-purpose signal lines of the flexible circuit board, the dielectric elements of the plurality of electrode units in the same row group are connected in parallel through different dual-purpose signal lines of the flexible circuit board, and the dielectric elements of the plurality of electrode units in different row groups and different column groups are connected in parallel to different dual-purpose signal lines of the flexible circuit board.

[0019] Furthermore, the dielectric elements of the plurality of electrode units in the same column group are connected in parallel with the signal ends of the respective temperature sensors through the same dual-purpose signal line of the flexible circuit board, and the dielectric elements of the plurality of electrode units in different column groups are connected in parallel with the signal ends of the respective temperature sensors through different dual-purpose signal lines of the flexible circuit board.

[0020] Furthermore, the ground ends of the temperature sensors of the multiple electrode units located in the same row group are short-circuited through the same ground line of the flexible circuit board, and the ground ends of the temperature sensors of the multiple electrode units located in the same column group are connected in parallel through different ground lines of the flexible circuit board; the signal ends of the temperature sensors of the multiple electrode units located in the same row group are connected in parallel through different dual-purpose signal lines of the flexible circuit board, and the signal ends of the temperature sensors of the multiple electrode units located in the same column group are short-circuited through the same dual-purpose signal line of the flexible circuit board.

[0021] Furthermore, the dielectric elements of the plurality of electrode units located in the same row group are respectively connected in parallel through different dual-purpose signal lines of the flexible circuit board, and the dielectric elements of the plurality of electrode units located in the same column group are all short-circuited through the same dual-purpose signal line of the flexible circuit board.

[0022] Furthermore, the temperature signals detected by the temperature sensors in each row group are sampled simultaneously after the handshake chip completes the handshake communication.

[0023] Furthermore, the sampled temperature signal detected by the temperature sensor is used to characterize the type of the electrode sheet.

[0024] Furthermore, the handshake chip has a ground pin electrically connected to the ground trace and a communication pin electrically connected to the communication line, and the ground pin is connected to one ground line among the multiple ground lines through the ground trace.

[0025] Furthermore, the handshake chip stores energy when the communication line transmits a high level and releases energy when the communication line transmits a low level.

[0026] Furthermore, the sampled temperature signal detected by the temperature sensor is also used to indicate whether the electrode sheet has a temperature abnormality.

[0027] According to the electrode sheet of the present application, its flexible circuit board is provided with a plurality of dual-purpose signal lines, which can transmit AC signals in the first mode and transmit DC signals or collect temperature detection signals of each electrode unit in the second mode. There is no need to set up a separate conductive trace used only for transmitting AC signals, which can reduce the number of wire cores of the wires connecting the electrode sheet and the adapter, and simplify the wiring design of the flexible circuit board of the electrode sheet.

[0028] To achieve the above-mentioned purpose, the present application also provides the following technical solution: a tumor electric field treatment system, comprising at least one pair of the aforementioned electrode sheets.

[0029] Furthermore, it also includes: an electric field generator, configured to apply an alternating current signal to multiple electrode units of the electrode sheet via the dual-purpose signal line of the electrode sheet; and an adapter, connected between the electrode sheet and the electric field generator, and configured to transmit the alternating current signal generated by the electric field generator to the multiplexed dual-purpose signal line of the electrode sheet, and also configured to receive the temperature signal detected by the multiplexed dual-purpose signal line of the electrode sheet, and further configured to perform handshake communication with the handshake chip, and to sample the temperature signal detected by each electrode unit in each row group in a time-sharing manner after completing the handshake communication.

[0030] Furthermore, the adapter includes: an AC signal line configured to apply an alternating current signal to each of the electrode units in the corresponding column group through the multiple dual-purpose signal lines.

[0031] Furthermore, the adapter also includes the switch unit, which includes: multiple groups of grounding switches, each group of grounding switches is electrically connected to a corresponding electrode sheet and includes multiple grounding switches, and the multiple grounding switches in each group of grounding switches are respectively electrically connected to the multiple grounding lines of the corresponding electrode sheet and are configured to control the conduction or disconnection of the multiple grounding lines.

[0032] Furthermore, the adapter also includes: multiple groups of analog-to-digital converters, which are respectively electrically connected to the multiple dual-purpose signal lines of the corresponding electrode sheets, and are configured to receive the temperature signals detected by the multiple dual-purpose signal lines of the corresponding electrode sheets and convert the temperature signals from analog signals to digital signals, wherein each group of analog-to-digital converters includes multiple detection channels, and each detection channel is used to connect to a corresponding one dual-purpose signal line among the multiple dual-purpose signal lines.

[0033] Furthermore, the switch unit also includes: multiple groups of bidirectional switches, corresponding one-to-one to the multiple electrode sheets, each group of the bidirectional switches includes multiple bidirectional switches, and the multiple bidirectional switches in each group of bidirectional switches are electrically connected one-to-one to the multiple dual-purpose signal lines of the corresponding electrode sheets; wherein each of the bidirectional switches also has a sampling end electrically connected to a corresponding detection channel in the corresponding analog-to-digital converter and an input end electrically connected to the AC signal line.

[0034] Furthermore, the adapter also includes: a first controller, which is connected to the multiple groups of grounding switches and the multiple groups of bidirectional switching switches respectively, and is configured to: control the opening and closing states of the corresponding groups of grounding switches in a cyclic manner, and then conduct each of the multiple grounding lines of the corresponding electrode sheets in turn; and control the switching states of the corresponding groups of bidirectional switching switches, so that each of the bidirectional switching switches is placed at the sampling end to output the detected temperature signal or at the input end to transmit the AC signal; and configure the switching state of the corresponding group of grounding switches when receiving the handshake signal sent by the electric field generator. The handshake chip is powered on by configuring the switching state of each grounding switch in the corresponding group and the switching state of each double-cut switch in the corresponding group of bidirectional switches, and the switching state of each temperature sensor in the corresponding row group is configured. The temperature signals are sampled by the analog-to-digital converters in the corresponding group through the corresponding detection channels at the same time, and the temperature signals obtained are converted into analog-to-digital signals to obtain multiple digital signals.

[0035] Furthermore, the adapter further includes: a first communication unit configured to obtain digital signals output by the multiple groups of analog-to-digital converters and send the digital signals to the electric field generator.

[0036] Furthermore, the electric field generator is further configured to control or adjust the alternating current signal applied to the corresponding electrode unit among the plurality of electrode units of the corresponding electrode sheet according to the received digital signal.

[0037] Furthermore, the first communication unit is controlled by the first controller and serially transmits the digital signal converted by the analog-to-digital converter.

[0038] Furthermore, the first controller is also used to identify the type of the corresponding electrode sheet according to the multiple digital signals.

[0039] Furthermore, the first controller is also used to determine whether the temperature of the corresponding electrode sheet is abnormal based on the multiple digital signals during the process of the electric field generator transmitting the alternating electric signal to the corresponding electrode sheet.

[0040] Furthermore, the first controller is further configured to send the plurality of digital signals to the electric field generator so that the electric field generator identifies the type of the corresponding electrode sheet according to the plurality of digital signals.

[0041] Furthermore, the electric field generator is also used to determine whether the corresponding electrode sheet has temperature abnormality according to the multiple digital signals during the process of transmitting the alternating electric signal to the corresponding electrode sheet.

[0042] Furthermore, the adapter includes an AC signal line, and the AC signal line is configured to provide an alternating current signal to each of the electrode units in the corresponding column group through the multiple dual-purpose signal lines.

[0043] To achieve the above-mentioned purpose, the present application also provides the following technical solutions: a temperature detection method, applied to the aforementioned electrode sheet or to the aforementioned tumor electric field therapy system, the method comprising the following steps: performing handshake communication with the handshake chip through the adapter to determine the connection status of the corresponding electrode sheet; when each of the electrode sheets is normally connected to the adapter, the temperature signals detected by each electrode unit in each of the row groups are sampled in a time-sharing manner by configuring the on and off states of the multiple ground lines and the multiplexed signal lines of the electrode sheets.

[0044] Furthermore, the multiple dual-purpose signal lines of the electrode sheet are all led to their respective sampling ends, each of the multiple grounding lines of the electrode sheet is turned on in sequence, and the temperature signals detected by each electrode unit of the electrode sheet are collected row by row through the multiple dual-purpose signal lines.

[0045] To achieve the above-mentioned purpose, the present application also provides the following technical solution: a signal control method for tumor electric field therapy, applied to the aforementioned electrode sheet or to the aforementioned tumor electric field therapy system. When the handshake chip confirms that the electrode sheet is normally connected, the signal for tumor electric field therapy is achieved by combining and controlling the conduction and disconnection of multiple dual-purpose signal lines and multiple ground lines, and cyclically switching between applying an AC signal and applying a DC signal to each electrode unit of the electrode sheet for collecting or transmitting the detected temperature signal through the multiple dual-purpose signal lines.

[0046] Furthermore, the process of applying an AC signal to each electrode unit of the electrode sheet includes the following steps: disconnecting the multiple grounding lines that are electrically connected one-to-one to the electrode units in each row group of the electrode sheet, and at the same time, connecting the multiple dual-purpose signal lines that are electrically connected one-to-one to the electrode units in each column group of the electrode sheet to their respective input ends to transmit the AC signal to each electrode unit through the multiple dual-purpose signal lines electrically connected to the electrode sheet.

[0047] Furthermore, the process of transmitting the detected temperature signal to each electrode unit of the electrode sheet includes the following steps: connecting the multiple dual-purpose signal lines connected to the electrode units in each column group of the electrode sheet to their respective acquisition ends to transmit a DC signal to each electrode unit through the multiple dual-purpose signal lines electrically connected to the electrode sheet; and sequentially and time-sharingly connecting one of the multiple grounding lines electrically connected to the electrode units in each row group of the electrode sheet in a one-to-one manner to complete the transmission of the temperature signals detected by all the electrode units in each row group of the electrode sheet row by row through the multiple dual-purpose signal lines electrically connected to the electrode sheet.

[0048] The above description is only an overview of the technical solution of the present application. In order to more clearly understand the technical means of the present application, it can be implemented in accordance with the contents of the specification. In order to make the above and other purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are listed below. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] Figure 1 This is a schematic diagram of a tumor treating field system according to an embodiment of the present application, which shows a schematic diagram of the spatial structure of the electrode sheet according to the first embodiment;

[0050] Figure 2 For use in this application Figure 1 A schematic diagram of the structural layout of an alternative embodiment of the electrode sheet of the first embodiment of the tumor electric field treating system is shown;

[0051] Figure 3 For this application Figure 1The circuit connection diagram of the tumor electric field system is shown in FIG. Figure 1 The electrode sheet of the first embodiment shown in FIG. Figure 2 The electrode sheet of the modified embodiment shown in Figure 1 A circuit connection diagram of the adapter of the first embodiment shown in FIG;

[0052] Figure 4 For this application Figure 3 A schematic block diagram of the internal structure of the adapter shown;

[0053] Figure 5 For this application Figure 1 A schematic block diagram of the internal structure of an electric field generator of a tumor treating field system is shown;

[0054] Figure 6 and Figure 3 Similarly, the circuit connection diagram of the tumor electric field treatment system of the second embodiment of the present application is shown, which shows the electrode sheet and the second embodiment of the tumor electric field treatment system of the present application. Figure 3 The circuit connection diagram of the adapter shown;

[0055] Figure 7 and Figure 3 Similarly, the circuit connection diagram of the tumor electric field treatment system of the third embodiment of the present application is shown, which shows the electrode sheet and the third embodiment of the tumor electric field treatment system of the present application. Figure 3 The circuit connection diagram of the adapter shown;

[0056] Figure 8 and Figure 3 Similarly, the circuit connection diagram of the tumor electric field treatment system of the fourth embodiment of the present application is shown, which shows the electrode sheet and the fourth embodiment of the tumor electric field treatment system of the present application. Figure 3 The circuit connection diagram of the adapter shown;

[0057] Figure 9 and Figure 3 Similarly, the circuit connection diagram of the tumor electric field treatment system of the fifth embodiment of the present application is shown, which shows the electrode sheet and the fifth embodiment of the tumor electric field treatment system of the present application. Figure 3 The circuit connection diagram of the adapter shown;

[0058] Figure 10 A schematic flow chart of a temperature detection method for the tumor electric field therapy system of this application;

[0059] Figure 11 This is the workflow diagram of the tumor electric field treatment system for this application;

[0060] Figure 12This is another flow chart of the temperature detection method of the tumor electric field therapy system of the present application;

[0061] Figure 13 This is a flow chart of the method for controlling the application of alternating current signals for electric field therapy of tumors in this application;

[0062] Figure 14 This is a flow chart of the signal control method for tumor electric field therapy in this application;

[0063] Figure 15 This is a flow chart of the electrode temperature detection method of this application;

[0064] Figure 16 This is a flow chart of the method for applying alternating current signals for tumor electric field therapy in this application.

[0065] Description of reference numerals:

[0066] Tumor electric field therapy system 100, electrode sheets 10, 10', 10D, 10E, 10F, 10H, flexible circuit boards 11, 11D, 11E, 11F, 11H, connecting portions 111, 111', connecting portions 112, 112', bridging portions 113, 113', trunks 114, 114', branches 115, 115', first intervals D1, D1', second intervals D2, D2', electrode units 12, 12', first cables 13, 13', temperature sensor 14, ground terminal 1 4-1, signal terminal 14-2, dielectric element 15, diode 16, handshake chip 17, ground trace 171, communication line 172, ground line 18, first ground line 18-1, second ground line 18-2, third ground line 18-3, fourth ground line 18-4, dual-purpose signal line 19, first dual-purpose signal line 19-1, second dual-purpose signal line 19-2, third dual-purpose signal line 19-3, fourth dual-purpose signal line 19-4, fifth dual-purpose signal line 19-5, adapter 20, second cable 21, A controller 22, an analog-to-digital converter 23, a voltage divider resistor 24, a grounding switch 25, a first grounding switch 25-1, a second grounding switch 25-2, a third grounding switch 25-3, a fourth grounding switch 25-4, a bidirectional switch 26, a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3, a fourth bidirectional switch 26-4, a fifth bidirectional switch 26-5, a first communication unit 27, an AC signal line 28, a first power supply module 29, a communication Transmission line 211, electric field generator 30, second power supply module 31, second controller 32, second communication unit 33, AC signal generator 34, AC signal switch 35, first AC signal switch 35-1, first AC signal switch 35-2, first AC signal switch 35-3, first AC signal switch 35-4, first connectors 40, 40D, 40E, 40F, 40H, first plugs 41, 41', first socket 42, second connector 50, second plug 51, second socket 52. DETAILED DESCRIPTION

[0067] The following embodiments of the technical solution of the present application will be described in detail with reference to the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of the present application and are therefore only examples and are not intended to limit the scope of protection of the present application.

[0068] Figure 1 FIG. 1 is a schematic diagram of a tumor electric field treatment system 100 according to an embodiment of the present application. Figure 1As shown, the tumor electric field therapy system 100 includes: at least one pair of electrode sheets 10, an adapter 20 connected to the electrode sheets 10, and an electric field generator 30 connected to the adapter 20. The electric field generator 30 generates an alternating current signal for tumor treatment and applies the alternating current signal to the electrode sheets 10 through the adapter 20, so that a therapeutic electric field is generated between the paired electrode sheets 10. The adapter 20 is electrically connected between the electrode sheets 10 and the electric field generator 30, and is used to transmit the alternating current signal generated by the electric field generator 30 to the electrode sheets 10. In other words, the electric field generator 30 is capable of generating an alternating current signal, and the alternating current signal generated by the electric field generator 30 is transmitted to each electrode sheet 10 through the adapter 20, so that a therapeutic electric field for treating tumors is generated between the same pair of electrode sheets 10. As shown Figure 1 As shown, in this embodiment, the number of electrode sheets 10 is 4. From the perspective of spatial structural arrangement, each electrode sheet 10 includes a plurality of electrode units 12 that are both axially symmetrically arranged and centrally symmetrically arranged and of the same number, a plurality of connecting portions 111 located between two adjacent electrode units 12, a bridging portion 113 erected between two adjacent connecting portions 111, a wiring portion 112 connected to the bridging portion 113, and a first cable 13 connected to the wiring portion 112. The bridging portion 113 and the wiring portion 112 are arranged vertically to form a "T" shape. The bridging portion 113 is erected between two adjacent connecting portions 111. Each electrode unit 12 of the electrode sheet 10 is electrically connected to the adapter 20 via a first cable 13 having 10-core conductors.

[0069] Each electrode unit 12 has a temperature sensor 14 and a dielectric element 15. The temperature sensor 14 is used to detect the temperature of the part of the patient's body surface to which the electrode unit 12 is applied. It can be a thermistor element or a temperature sensor other than a thermistor, and can be set at any position on the electrode unit 12. The dielectric element 15 is used to apply an alternating current signal to the patient's tumor site. The dielectric element 15 can be a dielectric ceramic sheet or a polymer dielectric layer composed of a polymer material. In this embodiment, each dielectric element 15 has a through-hole (unnumbered) provided in the middle for accommodating a corresponding temperature sensor 14. Each electrode unit 12 can also include a diode 16 connected in series with the temperature sensor 14, which can prevent the reverse flow of current to prevent the detection signal from other electrode units 12 from affecting the temperature sensor 14. The ground terminal 14-1 of the temperature sensor 14 is connected in series with the anode of the diode 16 and is grounded through the cathode of the diode 16.

[0070] In a first mode, the electrode unit 12 applies an AC signal via the dielectric element 15. In a second mode, the temperature sensor 14 detects or collects the temperature of the patient's body surface to which the corresponding electrode unit 12 is applied. In a third mode, the application of the AC signal and temperature detection and collection cease. The first, second, and third modes do not overlap in time periods. That is, the time periods during which the dielectric element 15 of the electrode unit 12 applies the AC signal are staggered and do not overlap with the time periods during which the temperature sensor 14 detects temperature. The electrode unit 12 can cyclically switch between applying the AC signal via its dielectric element 15 and detecting temperature via its temperature sensor 14, that is, the electrode unit 12 can cyclically switch between the first and second modes. The electrode unit 12 can also cyclically switch between the first, second, and third modes, that is, the electrode unit 12 cyclically switches between applying the AC signal via the dielectric element 15, collecting or detecting temperature via the temperature sensor 14, and then cessation of applying the AC signal and collecting temperature.

[0071] Each electrode sheet 10 includes an electrode array (unnumbered) consisting of 20 electrode units 12. The electrode array (unnumbered) also has a flexible circuit board 11 including a connecting portion 111, a wiring portion 112, and a bridging portion 113. The 20 electrode units 12 are distributed in an electrode array (unnumbered) arranged in four rows and six columns. Specifically, the first and last rows each have four electrode units 12, and the middle two rows each have six electrode units 12. The four electrode units 12 in the first row are respectively located in each of the second to fifth columns, the six electrode units 12 in each of the middle two rows are respectively located in each of the first to sixth columns, and the four electrode units 12 in the last row are also respectively located in each of the second to fifth columns. The connecting portion 111 is located only between two adjacent electrode units 12 arranged in the column direction in each of the third and fourth columns, and between two adjacent electrode units 12 in the row direction, excluding the two electrode units 12 in the third and fourth columns. That is, the two adjacent electrode units 12 in the third and fourth columns are connected only in the column direction via the connecting portion 111, and are disconnected in the row direction, not connected by the connecting portion 111. The electrode units 12 in each of the first, second, fifth, and sixth columns are connected only to the electrode units 12 adjacent in the row direction via the horizontally arranged connecting portion 111, and are disconnected in the column direction from the electrode units 12 adjacent to them. In other words, the two adjacent electrode units 12 in the first, second, fifth, and sixth columns are disconnected.

[0072] The electrode units 12 in the third column and the longitudinally disposed connecting portions 111 between the electrode units 12 in that column, as well as the electrode units 12 in the fourth column and the longitudinally disposed connecting portions 111 between the electrode units 12 in that column, constitute the backbone 114 of the electrode array (unnumbered). The connecting portions 111 located on opposite sides of the electrode units 12 in the third and fourth columns, connected to the electrode units 12 in the third and fourth columns via the transversely disposed connecting portions 111, and the electrode units 12 connected to the transversely disposed connecting portions 111, constitute the branches 115 of the electrode array (unnumbered). In other words, in this embodiment, the electrode array (unnumbered) includes two backbones 114 and a plurality of branches 115 extending laterally from the two backbones 114. Each branch 115 has a free end distal from the backbone 114. The free ends of adjacent branches 115 are disconnected, and the position and distance between adjacent branches 115 can be freely adjusted according to actual usage scenarios. Specifically, one trunk 114 is composed of the electrode units 12 in the third column and the longitudinally arranged connecting portions 111 between adjacent electrode units 12 in the column. Another trunk 114 is composed of the electrode units 12 in the fourth column and the longitudinally arranged connecting portions 111 between adjacent electrode units 12 in the column. The remaining electrode units 12 connected to the trunk 114 via the transversely arranged connecting portions 111 and the transversely arranged connecting portions 111 are all branches 115.

[0073] Specifically, the branches 115 are: a connecting portion 111 extending laterally to the left from the electrode unit 12 in the first row of the third column and located in the first row, and an electrode unit 12 connected to the connecting portion 111 and located in the second column of the first row; two connecting portions 111 extending laterally to the left from the electrode unit 12 in the second row of the third column and located in the second row, and two electrode units 12 located in the first column of the second row and the second column of the second row; two connecting portions 111 extending laterally to the left from the electrode unit 12 in the third row of the third column and located in the third row, and two electrode units 12 located in the first column of the third row and the second column of the third row; a connecting portion 111 extending laterally to the left from the electrode unit 12 in the fourth row and located in the fourth row, and The electrode unit 12 in the second column of the fourth row; a connecting portion 111 extending laterally to the right from the electrode unit 12 in the first row of the fourth column and located in the first row, and the electrode unit 12 located in the fifth column of the first row; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the second row of the fourth column and located in the second row, and two electrode units 12 located in the fifth column of the second row and the sixth column of the second row; two connecting portions 111 extending laterally to the right from the electrode unit 12 in the third row of the fourth column and located in the third row, and two electrode units 12 located in the fifth column of the third row and the sixth column of the third row; a connecting portion 111 extending laterally to the right from the electrode unit 12 in the fourth row of the fourth column and located in the fourth row, and the electrode unit 12 located in the fifth column of the fourth row.

[0074] The electrode array (unnumbered) is divided into a symmetrical left portion comprising three columns on the left and a right portion comprising three columns on the right, and the left portion and the right portion are connected only by a bridge portion 113. The left portion is composed of a trunk 114 located in the third column and a plurality of branches 115 extending laterally to the left from the trunk 114, and the right portion is composed of a trunk 114 located in the fourth column and a plurality of branches 115 extending laterally to the right from the trunk 115. The two trunks 114 are connected by a bridge portion 113 provided therebetween. Specifically, the two trunks 114 are electrically connected by a bridge portion 113 provided between a connection portion 111 connecting the electrode unit 12 in the second row of the third column and the electrode unit 12 in the third row of the third column and a connection portion 111 connecting the electrode unit 12 in the second row of the fourth column and the electrode unit 12 in the third row of the fourth column. The connecting portion 111 connecting the electrode unit 12 in the second row of the third column with the electrode unit 12 in the third row of the third column, the connecting portion 111 connecting the electrode unit 12 in the second row of the fourth column with the electrode unit 12 in the third row of the fourth column, and the bridging portion 113 are generally arranged in an "H" shape. In other embodiments, the bridging portion 113 may also be provided between an electrode unit 12 in the third column and an electrode unit 12 in the fourth column. Alternatively, the bridging portion 113 may be provided between two electrode units 12 in the third and fourth columns that are adjacent in the row direction.

[0075] Each electrode unit 12 can be divided into an electrode unit 12 located at the periphery and an electrode unit 12 located at the center according to its position in the electrode array (unnumbered). The electrode units 12 located at the periphery include four electrode units 12 located in the first row, two electrode units 12 located at opposite ends of the second row, two electrode units 12 located at opposite ends of the third row, and four electrode units 12 located in the fourth row. The electrode units 12 located at the center include four electrode units 12 located in the middle of the second row and four electrode units 12 located in the middle of the third row. Some adjacent two electrode units 12 in the plurality of electrode units 12 located at the periphery are connected by a laterally arranged connecting portion 111, and some adjacent two electrode units 12 are arranged in a disconnected state. Among the plurality of electrode units 12 located at the periphery, the adjacent two electrode units 12 connected by the connecting portion 111 are two electrode units 12 that are adjacent in some rows. Specifically, among the plurality of electrode units 12 located at the periphery, two adjacent electrode units 12 in the column direction and two adjacent electrode units 12 in the diagonal direction are all disconnected; some adjacent electrode units 12 in the row direction are also disconnected; and only some adjacent electrode units 12 in the row direction are connected by a laterally extending connection portion 111. Among the plurality of electrode units 12 located at the center, only two adjacent electrode units 12 in the column direction on the trunk 114 are connected by a longitudinally arranged connection portion 111, and only two adjacent electrode units 12 in the row direction on the branches 115 are connected by a laterally arranged connection portion 111.

[0076] The electrode array (unnumbered) also includes spaces (unnumbered) formed between the spaced electrode units 12. These spaces allow moisture from the patient's body to escape, heat exchange between the patient's skin and the surrounding environment, and allow the patient's skin to breathe freely. They also allow for flexible adjustment of the position and spacing between the branches 115 and prevent wrinkles when the electrode sheet 10 is applied. The spaces (unnumbered) include a first space D1 between the two trunks 114 and a second space D2 between the branches 115. The first space D1 is located between the third and fourth columns of electrode units 12, while the second space D2 is located between adjacent rows of electrode units 12. That is, going up along the row, the electrode unit 12 located in the third column is disconnected from the adjacent electrode unit 12 located in the fourth column, and no connecting portion 111 is provided, but the aforementioned first interval D1 is formed; and going up along the column, only the two adjacent electrode units 12 in the third and fourth columns are connected by the connecting portion 111, and the two adjacent electrode units 12 in the column direction in each of the other four columns are not connected by the connecting portion 111 but form the aforementioned second interval D2. The setting of the first and second intervals D1 and D2 can also increase the degree of freedom of some electrode units 12, and can also avoid wrinkles when attaching the electrode sheet 10.

[0077] The electrode sheet 10 also includes a handshake chip 17 disposed on the flexible circuit board 11 and used to confirm its connection status. The handshake chip 17 can communicate with the electric field generator 30 through the adapter 20 to determine the connection status between the electrode sheet 10 and the adapter 20. The electric field generator 30 of the tumor electric field therapy system 100 first sends a handshake communication signal to the handshake chip 17 of the electrode sheet 10 through the adapter 20 and determines the connection status of the electrode sheet 10 based on whether it receives feedback from the handshake chip 17. After confirming that the electrode sheet 10 is properly connected through the handshake chip 17, the electric field generator 30 of the tumor electric field therapy system 100 applies an AC signal to the dielectric element 15 of the electrode sheet 10 or transmits a DC signal to each temperature sensor 14 of the electrode sheet 10 to collect temperature detection signals. The handshake chip 17 can be an EEPROM with encryption function.

[0078] In other embodiments, the tumor electric field therapy system 100 may also have more or fewer electrode sheets 10. In other embodiments, each pair of electrode sheets 10 has the same or different numbers of electrode units 12, and different pairs of electrode sheets 10 may also have different numbers of electrode units 12. In other embodiments, the 20 electrode units 12 may also be arranged in other ways. Of course, in other embodiments, the electrode sheet 10 may also have other numbers of electrode units 12. In other embodiments, the 20 electrode units 12 may also be arranged in other ways, such as Figure 2 Of course, in other embodiments, the electrode sheet 10 may also have other numbers of electrode units 12. In short, the implementation of the present application is not limited by the number and arrangement of the electrode units 12 of the electrode sheet 10.

[0079] Figure 2 The electrode sheet 10' shown is Figure 1A modified embodiment of the electrode sheet 10 shown in the figure has the same spatial structure as the electrode sheet 10 and also includes a plurality of electrode units 12' arranged at intervals, a plurality of connecting portions 111' located between two adjacent electrode units 12', a wiring portion 112' connected to the bridging portion 113', and a first cable 13' connected to the wiring portion 112', a first interval D1 formed between the third column electrode unit 12' and the fourth column electrode unit 12', and a second interval D2' formed between the electrode units 12' in adjacent rows; the connecting portion 111', the wiring portion 112', and the bridging portion 113' also constitute a flexible circuit board (not numbered), the electrode sheet 10' is also connected to the adapter 20 via the first plug 41' of the first cable 13' having 10 cores. The only difference is that the two adjacent electrode units 12' in the fourth column are disconnected and not connected by the longitudinal connection portion 111'. However, the two adjacent electrode units 12' in the fifth column are connected by the longitudinal connection portion 111'. Each electrode unit 12' in the fourth column is connected to the adjacent electrode unit 12' in the fifth column via a transverse connection portion 111'. The bridge portion 113' connects the two electrode units 12' in the third row and the third column with the two electrode units 12' in the third row and the fourth column. One trunk 114' is formed by the electrode units 12' in the third column and the connection portion 111' between the electrode units 12' in that column. Another trunk 114' is formed by the electrode units 12' in the fifth column and the connection portion 111' between the electrode units 12' in that column. The structure of the left part of the left three columns of the electrode array (not numbered) is similar to Figure 1 The left side of the electrode array (unnumbered) shown in the figure has the same structure, except that the right side has branches 115' extending from the left and right sides of the corresponding electrode units 12' in the main trunk 114' due to the position change from the fourth column to the fifth column.

[0080] Figure 3 for Figure 1 The electrode sheet 10 or the electrode sheet 100 of the first embodiment of the tumor electric field treatment system 100 is shown. Figure 2 The circuit connection diagram of the electrode sheet 10' of the modified embodiment and the adapter 20 of the first embodiment is shown. It is worth noting that: Figure 3 The arrangement of the electrode units 12 is shown to more clearly illustrate the electrical connection between an electrode sheet 10 and the adapter 20. Figure 3 The arrangement of the electrode units 12 shown does not represent the spatial arrangement of the electrode units 12. The following describes the circuit connection by taking the electrode sheet 10 in the first embodiment as an example.

[0081] Combine Figure 1 as well as Figure 3In this embodiment, each electrode sheet 10 is provided with 20 electrode units 12. The 20 electrode units 12 are arranged in the order of 1 to 20 for circuit connection, divided into four row groups and five column groups. That is, the 20 electrode units 12 are arranged in four rows and five columns for circuit connection. The temperature sensor 14 of each electrode unit 12 includes a ground terminal 14-1 and a signal terminal 14-2. The dielectric element 15 and temperature sensor 14 of each electrode unit 12 are soldered to the flexible circuit board 11, and the dielectric element 15 is short-circuited with the signal terminal 14-2 of the corresponding temperature sensor 14. Since the electrode units 12 are arranged in four rows and five columns for circuit connection, and each electrode unit includes a corresponding dielectric element 15 and a corresponding temperature sensor 14, the multiple temperature sensors 14 are also arranged in four rows and five columns for circuit connection, and the multiple dielectric elements 15 are also arranged in four rows and five columns for circuit connection. It should be noted that the arrangement here is to more clearly show the electrical connection between the electrode sheet 10 and the adapter 20, and does not represent the arrangement of the electrode unit 12 in the spatial structure. The spatial structure may be as follows: Figure 1 The illustrated structure is generally an array, but may also be other structures, such as petal-shaped or scattered, and may be regular or irregular. The dielectric element 15 is configured to apply an alternating electric field to the patient's tumor site. The temperature sensor 14 is configured to detect the temperature of the patient's body surface in contact with the electrode sheet 10 and output a temperature detection signal to the adapter 20.

[0082] The flexible printed circuit board 11 is embedded with multiple conductive traces 171, 172, 18, and 19. These traces include multiple ground lines 18, a multiplexed signal line 19, a ground trace 171, and a communication line 172. One end of ground trace 171 is connected to a ground pin of the handshake chip 17, and the other end is connected to any of the ground traces 18. The ground pin of the handshake chip 17 is connected to ground trace 171, and its communication pin is electrically connected to communication line 172. In other words, the handshake chip 17 is grounded via ground line 18 connected to ground trace 171, and communicates with external devices via communication line 172. Specifically, the handshake chip 17 is grounded via a ground trace 171 connected to a ground line 18 via its ground pin. The handshake chip 17 then communicates with the electric field generator 30 via a communication line 172 on the flexible circuit board 11, a conductor electrically connected to the communication line 172 on the first cable 13, an adapter 20 electrically connected to the first cable 13, and an electric field generator 30 electrically connected to the adapter 20, thereby determining the connection status of the electrode sheet 10. The first cable 13 includes multiple conductors (not shown) that are electrically connected to the communication line 172, multiple ground lines 18, and multiple dual-purpose signal lines 19 on the flexible circuit board 11 in a one-to-one correspondence. The total number of communication lines 172, ground lines 18, and dual-purpose signal lines 19 embedded in the flexible circuit board 11 does not exceed 10. Therefore, the number of conductors in the first cable 13 does not exceed 11.

[0083] The number of conductive lines electrically connected to the ground wire 18 in the tumor electric field therapy system 100 is related to the number M of row groups of the electrode units 12, which can be greater than or equal to the number of row groups of the electrode units 12, where M is a positive integer. The number of conductive lines electrically connected to the dual-purpose signal lines 19 in the tumor electric field therapy system 100 is related to the number N of column groups of the electrode units 12, which can be greater than or equal to the number of column groups of the electrode units 12, where N is a positive integer. In this embodiment, the number of ground wires 18 is equal to the number M of row groups of the electrode units 12; the dual-purpose signal lines 19 are equal to the number N of column groups of the electrode units 12. The number of lines L embedded in the flexible circuit board 11 is equal to the sum of the number of ground wires 18 and the number of dual-purpose signal lines 19 plus 2, that is, L = M + N + 2. The number of conductors in the first cable 13 is M + N + 1.

[0084] The flexible circuit board 11's dual-purpose signal lines 19 are arranged one-to-one with the multiple column groups of electrode units 12. They are configured to transmit the AC signal generated by the electric field generator 30 to the dielectric elements 15 in each electrode unit 12 within the corresponding column group. Specifically, the dielectric elements 15 in the same column group are short-circuited by the same dual-purpose signal line 19 on the flexible circuit board 11, while the dielectric elements 15 in different column groups are connected in parallel via different dual-purpose signal lines 19 on the flexible circuit board 11. The dual-purpose signal lines 19 on the flexible circuit board 11 are electrically connected to corresponding wires in the first cable 13, and then electrically connected to the electric field generator 30 via the adapter 20. In other words, the dual-purpose signal lines 19 on the flexible circuit board 11 receive the AC signal generated by the electric field generator 30 via the first cable 13 and the adapter 20.

[0085] Multiple grounding lines 18 are provided in a one-to-one correspondence with the multiple row groups of electrode units 12. These lines are used to sequentially short-circuit the temperature sensors 14 of each electrode unit 12 in each row group to ground. Specifically, the ground terminals 14-1 of the temperature sensors 14 in the same row group are all short-circuited via the same grounding line 18 on the flexible circuit board 11. The ground terminals 14-1 of the temperature sensors 14 in different row groups are connected in parallel via different grounding lines 18 on the flexible circuit board 11. During the temperature detection period or in the second mode, only one of the multiple grounding lines 18 is connected at any one time; the remaining grounding lines 18 are disconnected.

[0086] Each of the multiplexed dual-purpose signal lines 19 is further configured to transmit a DC signal to the temperature sensor 14 in each electrode unit 12 in the corresponding column group to collect and transmit the detected temperature detection signal. The signal terminals 14-2 of the multiple temperature sensors 14 in different column groups are connected in parallel via different dual-purpose signal lines 19 on the flexible circuit board 11. The signal terminals 14-2 of the multiple temperature sensors 14 in the same column group are all short-circuited to the same dual-purpose signal line 19 on the flexible circuit board 11, with the short-circuit point serving as a temperature sampling point. Specifically, each dual-purpose signal line 19 is configured to short-circuit the signal terminal 14-2 of the temperature sensor 14 in at most one electrode unit 12 in each row group to an external device for receiving detection signals. Each of the multiplexed dual-purpose signal lines 19 is connected to a different signal terminal 14-2 of each temperature sensor 14 to prevent duplicate signals from being subsequently output by the dual-purpose signal lines 19. That is, when the number of electrode units 12 in a row group is the same as the number of dual-purpose signal lines 19, each dual-purpose signal line 19 is electrically connected to the signal end 14-2 of the temperature sensor 14 of a different electrode unit 12 in the row group. When the number of electrode units 12 in a row group is less than the number of dual-purpose signal lines 19, at least one dual-purpose signal line 19 is not electrically connected to the signal end 14-2 of the temperature sensor 14 of an electrode unit 12, and each of the remaining dual-purpose signal lines 19 is electrically connected to the signal end 14-2 of the temperature sensor 14 of a different electrode unit 12 in the row group. In this embodiment, the external device for receiving the detection signal is an adapter 20. The dual-purpose signal lines 19 of the flexible circuit board 11 receive the DC signal from the adapter 20 or the electric field generator 30 via the first cable 13, and transmit the collected or detected temperature signal to the adapter 20, and then transmit it to the electric field generator 30 via the adapter 20.

[0087] In this embodiment, when each electrode unit 12 is equipped with a temperature sensor 14 for temperature detection, the above-mentioned circuit design is used to reduce the number of wires in the first cable 13, thereby avoiding the cable becoming thicker and the cable becoming harder, which increases the difficulty of fixing the cable; at the same time, the increase in the number of wires in the first cable 13 is avoided to prevent the adhesion effect between the electrode sheet 10 and the body surface corresponding to the tumor site of the patient from being affected.

[0088] The grounding wires 18 and dual-purpose signal wires 19 embedded in the flexible circuit board 11 are a total of 9 lines. In this embodiment, the grounding wires 18 embedded in the flexible circuit board 11 are 4 lines, and the dual-purpose signal wires 19 are 5 lines. Specifically, the electrode sheet 10 of this embodiment includes 4 grounding wires 18, each of which is used to ground the ground ends 14-1 of the temperature sensors 14 in the same row group. The 4 grounding wires 18 of the electrode sheet 10 are respectively a first grounding wire 18-1, a second grounding wire 18-2, a third grounding wire 18-3, and a fourth grounding wire 18-4. Among the 4 row groups of the electrode sheet 10, the first row group includes electrode units 12-1 to 12-5, the second row group includes electrode units 12-6 to 12-10, the third row group includes electrode units 12-11 to 12-15, and the fourth row group includes electrode units 12-16 to 12-20. Specifically, the first grounding wire 18-1 is used to ground the electrode units 12-1 to 12-5 in the first row group; the second grounding wire 18-2 is used to ground the electrode units 12-6 to 12-10 in the second row group; the third grounding wire 18-3 is used to ground the electrode units 12-11 to 12-15 in the third row group; and the fourth grounding wire 18-4 is used to ground the electrode units 12-16 to 12-20 in the fourth row group. It should be noted that these grounding wires 18 can be selectively closed or opened, which can be achieved by connecting each grounding wire 18 in series with a switch, which will be described in detail below. The above-mentioned "grounding the electrode unit 12" can refer to grounding the ground terminal 14-1 of the temperature sensor 14 in the electrode unit 12, or it can refer to connecting the diode 16 in series with the temperature sensor 14 of the same electrode unit 12 and grounding them together. In short, each ground line 18 short-circuits the ground terminals 14 - 1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group and connects them to ground.

[0089] Continue to refer Figure 3As shown, the electrode sheet 10 of this embodiment also includes five dual-purpose signal lines 19. One end of each dual-purpose signal line 19 is connected to all electrode units 12 in each column group, and the other end is connected to an adapter 20 for receiving temperature detection signals and transmitting AC signals. In other words, for each row group, each dual-purpose signal line 19 can choose to connect to one of the electrode units 12 or not connect to any electrode unit 12 in the row group to avoid the dual-purpose signal line 19 subsequently outputting duplicate signals. Specifically, the five dual-purpose signal lines 19 of the electrode sheet 10 include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-1, electrode unit 12-6, electrode unit 12-11, and electrode unit 12-16, and the signal end 14-2 of the temperature sensor 14 of each of the four electrode units 12; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-2, electrode unit 12-7, electrode unit 12-12, and electrode unit 12-17, and the signal end 14-2 of the temperature sensor 14 of each of the four electrode units 12; one end of the third dual-purpose signal line 19-3 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-3, electrode unit 12-8, and electrode unit 12-1, respectively. 3. Electrode units 12-18: The dielectric elements 15 of each of the four electrode units 12 and the signal terminals 14-2 of each temperature sensor 14. One end of a fourth dual-purpose signal line 19-4 is simultaneously connected to the dielectric elements 15 of each of the four electrode units 12, namely, electrode unit 12-4, electrode unit 12-9, electrode unit 12-14, and electrode unit 12-19, and the signal terminals 14-2 of each temperature sensor 14. One end of a fifth dual-purpose signal line 19-5 is simultaneously connected to the dielectric elements 15 of each of the four electrode units 12, namely, electrode unit 12-5, electrode unit 12-10, electrode unit 12-15, and electrode unit 12-20, and the signal terminals 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 parallel-circuits the dielectric elements 15 and the signal terminals 14-2 of each temperature sensor 14 of each electrode unit 12 in the same column group, and is used for connection to an external device. It should be noted that these dual-purpose signal lines 19 can selectively transmit AC signals or receive temperature detection signals. This can be achieved by connecting each dual-purpose signal line 19 in series with a bidirectional switch 26 and coordinating the closing or opening of the grounding line 18. This will be described in detail below.

[0090] In other embodiments, the grounding wires 18 and dual-purpose signal wires 19 embedded in the flexible circuit board 11 may have other numbers according to the circuit arrangement and number of electrode units 12 in different electrode sheets, which will be described in detail in subsequent embodiments.

[0091] In this embodiment, the ground pin of the handshake chip 17, used to confirm the connection status of the electrode sheet 10, is connected to a fourth ground line 18-4 via a ground trace 171 embedded in the flexible printed circuit board 11. The first cable 13 has 10 conductors: four ground lines 18, five dual-purpose signal lines 19, and one communication line 172. The specific connection relationship and operating principle of the handshake chip 17 are described in detail below.

[0092] The tumor electric field therapy system 100 of this embodiment includes at least one pair of the aforementioned electrode sheets 10, an adapter 20 electrically connected to the electrode sheets 10, and an electric field generator 30 electrically connected to the adapter 20. The adapter 20 is connected between the electrode sheets 10 and the electric field generator 30. When the ground pin of the electric field generator 30 or the adapter 20 controls the handshake chip 17 to be grounded, the electric field generator 30 sends a handshake communication signal to the handshake chip 17 of the electrode sheet 10 via the adapter 20 and the communication line 172 of the electrode sheet 10 to determine the connection status of the electrode sheet 10. When the electrode sheet 10 is connected normally, the electric field generator 30 provides an AC signal to the dielectric elements 15 in the multiple electrode units 12 of the electrode sheet 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode sheet 10, or provides a DC signal to the temperature sensors 14 in the multiple electrode units 12 of the electrode sheet 10 via the adapter 20 and the dual-purpose signal line 19 of the electrode sheet 10, and is used to receive the temperature detection signals output by the temperature sensors 14 in the multiple electrode units 12. The adapter 20 is configured to send a handshake communication signal to the communication line 172 of the electrode sheet 10 according to the communication instruction of the electric field generator 30, and is configured to transmit the AC signal generated by the electric field generator 30 to the dual-purpose signal line 19 of the electrode sheet 10, and is further configured to transmit a DC signal to the dual-purpose signal line 19 of the electrode sheet and receive the temperature detection signal output by the multiplexed dual-purpose signal line 19 of the electrode sheet 10.

[0093] Continue to refer Figure 3 and Figure 4As shown, the adapter 20 includes: a first controller 22, a multi-channel communication transmission line 211 electrically connected to the first controller 22, multiple sets of analog-to-digital converters 23 connected to the first controller 22, multiple sets of voltage transformers 24 and multiple sets of grounding switches 25 corresponding to the multiple sets of analog-to-digital converters 23, multiple sets of bidirectional switches 26 connected to the multiple sets of analog-to-digital converters 23, a first communication unit 27, an AC signal line 28 connected to each set of bidirectional switches 26 in a one-to-one correspondence, and a first power module 29 connected to the first communication unit 27, the first controller 22, and the multiple sets of analog-to-digital converters 23. The first power module 29 provides a DC power supply VCC to the electronic components of the adapter 20. The adapter 20 also includes multiple circuit lines (unnumbered). The multiple circuit lines (unnumbered) are electrically connected to the multiple grounding lines 18, the multiplexed signal lines 19, and the communication lines 172 in the flexible circuit board 11 of the corresponding electrode sheet 10 through the first cables 13 of the corresponding electrode sheet 10. The multiple circuit lines (not numbered) include multiple AC signal lines 28 that transmit alternating current signals to corresponding electrode sheets 10 and are electrically connected to the multiplexed signal lines 19 within the flexible circuit boards 11 of the corresponding electrode sheets 10; multiple circuit lines (not numbered) that are electrically connected one-to-one with the multiplexed signal lines 19 within the flexible circuit boards 11 of the corresponding electrode sheets 10 and are used to power the temperature sensors 14 of the electrode sheets 10 or transmit temperature detection signals of the electrode sheets 10; multiple circuit lines (not numbered) that are electrically connected one-to-one with the multiple ground lines 18 within the flexible circuit boards 11 of the corresponding electrode sheets 10; and multiple communication transmission lines 211 that are electrically connected one-to-one with the multiple communication lines 172 within the flexible circuit boards 11 of the corresponding electrode sheets 10. The multiple communication transmission lines 211 are all connected to the first controller 22. Each communication transmission line 211 is connected to the communication line 172 of the flexible circuit board 11 through the corresponding first connector 40. By closing the ground switch 25 corresponding to the ground line 18 that short-circuits the ground pin of the handshake chip 17 of the flexible circuit board 11, the first controller 22 can be electrically connected to the handshake chip 17, so that the handshake chip 17 can obtain power and enable data communication functions.

[0094] The number P of circuit lines electrically connected between the adapter 20 and one electrode sheet 10 is equal to the sum of the number of rows M and the number of columns N of the electrode units 12 of the electrode sheet 10 plus 2; the number H of circuits electrically connected between the adapter 20 and X electrode sheets 10 is equal to X times the number of circuit lines electrically connected to a single electrode sheet 10, that is, H=XP=X*(M+N+2). The number of groups of grounding switches 25, the number of groups of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all related to the number of electrode sheets 10. The number of groups of grounding switches 25, the number of groups of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all the same; and are not less than the number of electrode sheets 10. Preferably, the number of groups of grounding switches 25, the number of groups of bidirectional switching switches 26, the number of AC lines 28, and the number of communication transmission lines 211 are all the same as the number of electrode sheets 10. The following is a detailed description taking the electrical connection between an electrode sheet 10 having 20 electrode units 12 and the adapter 20 as an example.

[0095] Each group of grounding switches 25 is provided with a plurality of grounding switches 25, and the plurality of grounding switches 25 are respectively connected to the adapter 20 and are respectively electrically connected to the circuit lines (not numbered) corresponding to the multi-way grounding lines 18 of the corresponding electrode sheet 10, and are configured to control the conduction or disconnection of the multi-way grounding lines 18. The circuit lines (not numbered) that are electrically connected to the multi-way grounding lines 18 of the electrode sheet 10 are grounded at one end close to the grounding switch 25. The number of grounding switches 25 in each group of grounding switches 25 is related to the number of grounding lines 18 of the flexible circuit board 11 of the corresponding electrode sheet 10, and the two are equal in this embodiment. Figure 3As shown, in this embodiment, each group of grounding switches 25 includes a first grounding switch 25-1, a second grounding switch 25-2, a third grounding switch 25-3, and a fourth grounding switch 25-4. Each group of multiple grounding switches 25 controls the closing or opening of a corresponding grounding line 18 of a corresponding electrode sheet 10. Specifically, the first grounding switch 25-1 is used to control the closing or disconnection of the first grounding line 18-1 of the corresponding electrode sheet 10, and can then cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the five electrode units 12 from electrode unit 12-1 to electrode unit 12-5 in the first row group of the electrode sheet 10; the second grounding switch 25-2 is used to control the closing or disconnection of the second grounding line 18-2 of the electrode sheet 10, and can then cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the five electrode units 12 from electrode unit 12-6 to electrode unit 12-10 in the second row group of the electrode sheet 10; the third grounding switch 25-3 is used to control the third grounding line 18-2 of the electrode sheet 10, and can then cooperate with the corresponding group of two-way switching switches 26 to control the power on and off of each temperature sensor 14 of the five electrode units 12 from electrode unit 12-6 to electrode unit 12-10 in the second row group of the electrode sheet 10; The closing or opening of the ground wire 18-3 can cooperate with the corresponding set of two-way switches 26 to control the power on and off of each temperature sensor 14 of the five electrode units 12 in the third row group of the electrode sheet 10, namely, electrode unit 12-11 to electrode unit 12-15. The fourth ground switch 25-4 is used to control the closing or opening of the fourth ground wire 18-4 of the electrode sheet 10, thereby judging the connection status of the electrode sheet 10 through the electrical connection status of the communication line 172 of the handshake chip 17 and the communication transmission line 211 of the adapter 20, and can also cooperate with the corresponding set of two-way switches 26 to control the power on and off of each temperature sensor 14 of the five electrode units 12 in the fourth row group of the electrode sheet 10, namely, electrode unit 12-16 to electrode unit 12-20. The above-mentioned ground switch 25 can be a mechanical switch, such as a relay. The ground switch 25 can also be an electronic switch, and each ground switch 25 can be opened and closed by the first controller 22 of the adapter 20.

[0096] In this embodiment, the multiple groups of grounding switches 25 are all electronic switches. The first controller 22 is in communication with the multiple groups of grounding switches 25 and is configured to sequentially and cyclically control the opening and closing states of the multiple grounding switches 25 in each group of grounding switches 25. This in turn sequentially connects each of the multiple grounding wires 18 of the corresponding electrode sheet 10 and coordinates the switching of the corresponding bidirectional switch 26 to sequentially and time-share the patient's body surface temperature detected by all temperature sensors 14 on the electrode sheet 10. The number of grounding switches 25 in each group is greater than or equal to the number of grounding wires 18 on the flexible circuit board 11 of the corresponding electrode sheet 10. In this embodiment, the number of grounding switches 25 in each group is the same as the number of grounding wires 18 of the corresponding electrode sheet 10.

[0097] Each set of two-way switches 26 is provided with a plurality of two-way switches 26. The plurality of two-way switches 26 in each set are respectively connected to the adapter 20 and are respectively electrically connected to the circuit lines (not numbered) corresponding to the multiplexed dual-purpose signal lines 19 of the corresponding electrode sheet 10. The number of two-way switches 26 in each set of two-way switches 26 is related to the number of dual-purpose signal lines 19 of the flexible circuit board 11 of the corresponding electrode sheet 10, and is greater than or equal to the number of dual-purpose signal lines 19 of the flexible circuit board 11 of the corresponding electrode sheet 10. Figure 3 In the illustrated embodiment, the two are equal. Each bidirectional switch 26 has a sampling terminal 1 and an input terminal 2. The sampling terminals 1 of the multiple bidirectional switches 26 in the same group are electrically connected to corresponding detection channels of the multiple detection channels of the corresponding group of analog-to-digital converters 23, and each detection channel corresponds to a corresponding temperature sampling point. The input terminal 2 of each bidirectional switch 26 in the same group is electrically connected to the same corresponding AC signal line 28. Each bidirectional switch 26 is configured to control the multiplexer signal line 19 to connect to the corresponding AC signal line 28 to transmit an alternating current signal or to connect to the corresponding detection channel of the corresponding group of analog-to-digital converters 23 to receive the temperature detection signal output by the temperature sensor 14.

[0098] like Figure 3 As shown, taking the electrical connection between one electrode sheet 10 and the adapter 20 as an example, in this embodiment having 20 electrode units 12, the plurality of bidirectional switches 26 are respectively a first bidirectional switch 26-1, a second bidirectional switch 26-2, a third bidirectional switch 26-3, a fourth bidirectional switch 26-4, and a fifth bidirectional switch 26-5. The plurality of bidirectional switches 26 in the same group each control a corresponding one of the multiplexed signal lines 19 of the same electrode sheet 10 to switch between transmitting an AC signal and transmitting a temperature detection signal.

[0099] Specifically, the first bidirectional switch 26-1 is used to control the switching of the first dual-purpose signal line 19-1 of the corresponding electrode sheet 10 between transmitting an AC signal and transmitting a temperature detection signal, thereby controlling the switching between the conduction of the dielectric elements 15 of the electrode units 12-1, 12-6, 12-11, and 12-16 in the first column group of the electrode sheet 10 and the conduction of the signal ends 14-2 of the temperature sensors 14 of the electrode units 12-1, 12-6, 12-11, and 12-16 in the first column group, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the first column of electrode units 12-1, 12-6, 12-11, and 12-16 transmit AC signals to the patient or output the temperature signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23. the second bidirectional switch 26-2 is used to control the switching between the transmission of the AC signal and the transmission of the temperature detection signal by the second dual-purpose signal line 19-2 of the corresponding electrode sheet 10, thereby controlling the conduction of the dielectric elements 15 of the electrode units 12-2, 12-7, 12-12, and 12-17 in the second column group of the electrode sheet 10 and the conduction of the signal ends 14-2 of the temperature sensors 14 of the electrode units 12-2, 12-7, 12-12, and 12-17 in the second column group, and cooperating with the corresponding grounding switches 25-1, 25-2, 25-3, and 25-4, so that the second column of electrode units 12-2, 12-7, 12-12, and 12-17 transmit the AC signal to the patient or output the temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23;The third bidirectional switch 26-3 is used to control the switching of the third dual-purpose signal line 19-3 of the corresponding electrode sheet 10 between transmitting an AC signal and transmitting a temperature detection signal, thereby controlling the switching between the conduction of the dielectric elements 15 of the electrode units 12-3, 12-8, 12-13, and 12-18 in the third column group of the electrode sheet 10 and the conduction of the signal terminals 14-2 of the temperature sensors 14 of the electrode units 12-3, 12-8, 12-13, and 12-18 in the third column group, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the third column of electrode units 12-3, 12-8, 12-13, and 12-18 transmits an AC signal to the patient or outputs the temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23. The fourth bidirectional switch 26-4 is used to control the switching between the transmission of the AC signal and the transmission of the temperature detection signal by the fourth dual-purpose signal line 19-4 of the corresponding electrode sheet 10, thereby controlling the conduction of the dielectric elements 15 of the electrode units 12-4, 12-9, 12-14, and 12-19 in the fourth column group of the electrode sheet 10 and the conduction of the signal terminals 14-2 of the temperature sensors 14 of the electrode units 12-4, 12-9, 12-14, and 12-19 in the fourth column group, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the fourth column of electrode units 12-4, 12-9, 12-14, and 12-19 transmits the AC signal to the patient or outputs the temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the analog-to-digital converter 23;The fifth bidirectional switch 26-5 is used to control the switching of the fifth dual-purpose signal line 19-5 of the corresponding electrode sheet 10 between transmitting alternating current signals and transmitting temperature detection signals, thereby controlling the conduction of the dielectric elements 15 of the electrode units 12-5, 12-10, 12-15, and 12-20 in the fifth column group of the electrode sheet 10 and the conduction of the signal ends 14-2 of the temperature sensors 14 of the electrode units 12-5, 12-10, 12-15, and 12-20 in the fifth column group, and cooperating with the corresponding first grounding switch 25-1, second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4, so that the fifth column of electrode units 12-5, 12-10, 12-15, and 12-20 transmit alternating current signals to the patient or output the temperature detection signals collected by the temperature sensors 14 of these electrode units 12 to the corresponding analog-to-digital converter 23. ;

[0100] When each set of grounding switches 25 is disconnected and the input end 2 of each set of bidirectional switching switches 26 is conductive and the sampling end 1 is disconnected, an AC signal can be transmitted to the dielectric element 15 of each electrode unit 12 of the corresponding electrode sheet 10. When the sampling end 1 of each set of bidirectional switching switches 26 is conductive and the input end 2 is disconnected, it can cooperate with each grounding switch 25 in the corresponding set of grounding switches 25 to transmit the temperature detection signal collected by the temperature sensor 14 of each electrode unit 12 on the electrode sheet 10 in a time-sharing manner. The above-mentioned bidirectional switching switches 26 can be mechanical switches, such as relays. The bidirectional switching switches 26 can also be electronic switches. The switching between the sampling end 1 and the input end 2 of each bidirectional switching switch 26 can be controlled by the first controller 22 of the adapter 20.

[0101] In this embodiment, the multiple sets of bidirectional switches 26 are all electronic switches. The first controller 22 is in communication with the multiple sets of bidirectional switches 26 and is configured to control the switching of multiple bidirectional switches 26 in each set of bidirectional switches 26 between their respective sampling terminals 1 and input terminals 2, and to coordinate the closing or opening of the corresponding grounding switches 25 to continuously monitor the patient's body surface temperature detected by all temperature sensors 14 on the electrode sheet 10 or to transmit an AC signal to the patient. In this embodiment, the multiple sets of grounding switches 25 and the multiple sets of bidirectional switches 26 collectively constitute a switch unit (not numbered).

[0102] In this embodiment, each group of analog-to-digital converters 23 is electrically connected to the sampling terminals 1 of the multiple bidirectional switches 26 in the corresponding group of bidirectional switches 26 through a multi-channel circuit line (unnumbered) in the adapter 20, and is configured to receive the temperature detection signal transmitted by the multiplexed signal line 19 of the corresponding electrode sheet 10, and convert the temperature detection signal from an analog signal to a digital signal. Each group of analog-to-digital converters 23 includes multiple detection channels A, B, C, D, and E, and each detection channel A, B, C, D, and E is used to connect to a corresponding one-way dual-purpose signal line 19 in the multiplexed signal line 19 through the corresponding bidirectional switch 26. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of bidirectional switches 26 in the corresponding group. The number of detection channels in each group of analog-to-digital converters 23 is related to the number of column groups of electrode units 12 of the corresponding electrode sheet 10. Specifically, the number of detection channels in each group of analog-to-digital converters 23 is equal to the number of bidirectional switches 26 in the corresponding group of bidirectional switches 26, which is not less than the number of columns of electrode units 12 of the corresponding electrode sheet 10. Figure 3 As shown, each group of analog-to-digital converters 23 includes a total of five detection channels A, B, C, D, and E, namely the first detection channel A, the second detection channel B, the third detection channel C, the fourth detection channel D, and the fifth detection channel E. The first detection channel A is connected to the first dual-purpose signal line 19-1 via the sampling terminal 1 of the first bidirectional switch 26-1, the second detection channel B is connected to the second dual-purpose signal line 19-2 via the sampling terminal 1 of the second bidirectional switch 26-2, the third detection channel C is connected to the third dual-purpose signal line 19-3 via the sampling terminal 1 of the third bidirectional switch 26-3, the fourth detection channel D is connected to the fourth dual-purpose signal line 19-4 via the sampling terminal 1 of the fourth bidirectional switch 26-4, and the fifth detection channel E is connected to the fifth dual-purpose signal line 19-5 via the sampling terminal 1 of the fifth bidirectional switch 26-5. Each detection channel A, B, C, D, and E is used to receive the temperature detection signal collected by the temperature sensor 14 of the electrode unit 12 to which the corresponding dual-purpose signal line 19 is connected. In addition, each detection channel A, B, C, D, E is connected to a first power module 29 for providing a detection voltage to the detection channel A, B, C, D, E via a corresponding voltage divider resistor 24 in the adapter 20. The first power module 29 provides a DC signal.

[0103] In this embodiment, the first communication unit 27 is configured to obtain the digital signals output by the multiple analog-to-digital converters 23 and send the digital signals to the electric field generator 30. The electric field generator 30 is also configured to control and adjust the voltage, current, or power of the AC signal provided to the multiple electrode units 12 of the electrode sheet 10 based on the received digital signals. For example, when any of the multiple digital signals received exceeds a preset threshold, it indicates that the temperature of the human body surface to which the corresponding dielectric element 15 is applied, detected by at least one temperature sensor 14 in the electrode sheet 10, exceeds a preset threshold temperature (e.g., 41°C, 42°C, etc.). At this time, the voltage, current, or power of the AC signal output by the electric field generator 30 can be appropriately reduced to prevent the electrode units 12 of the electrode sheet 10 from becoming too hot when the AC signal is applied, thereby causing low-temperature burns to the patient's skin. The above-mentioned preset threshold temperature and preset threshold value can be determined based on the human body safety threshold. The first communication unit 27 is controlled by the first controller 22 and serially transmits the digital signals converted by the multiple analog-to-digital converters 23. In this embodiment, the preset temperature threshold may be a value within the range of 36°C-45°C.

[0104] One end of each of the multiple communication transmission lines 211 embedded in the adapter 20 is connected to the first controller 22, and the other end is electrically connected to a communication line 172 electrically connected to a communication pin of the handshake chip 17 of the corresponding electrode sheet 10 via a corresponding wire of the corresponding first cable 13. The ground pin GND of the adapter 22 is also connected to the ground pin of the handshake chip 17 of the corresponding electrode sheet 10 via a wire electrically connected to a corresponding ground switch 25 and connected to the corresponding wire of the corresponding first cable 13, a ground wire 18 connected to both the corresponding wire of the corresponding first cable 13 and the ground trace 171, and a ground trace 171 short-circuited with the ground wire 18. That is, the first controller 22 controls a grounding switch 25 corresponding to a grounding line 18-4 that is short-circuited to the ground pin of the handshake chip 17 of the electrode sheet 10 to close, and sends a handshake communication signal to the communication line 172 of the electrode sheet 10 through the communication transmission line 211, and determines whether the connection between the electrode sheet 10 and the adapter 20 is normal based on whether the first controller 22 can receive feedback from the communication line 172 of the electrode sheet 10.

[0105] refer to Figure 4 as well as Figure 5 In this embodiment, the first power supply module 29 is electrically connected to the second power supply module 31 of the electric field generator 30 and is configured to supply power to the first controller 22, the multiple analog-to-digital converters 23, and the first communication unit 27 of the adapter 20. A first connector 40 is provided between each electrode sheet 10 and the adapter 20. The first connector 40 is suitable for connecting the corresponding electrode sheet 10 to the adapter 20. Figure 1As shown, the first connector 40 includes a first plug 41 provided at the end of the first cable 13 away from the electrode sheet 10, and a first socket 42 provided on the adapter 20. The first plug 41 and the first socket 42 are press-type spring connectors, that is, the first connector 40 uses a connector to connect the adapter 20 to the electrode sheet 10. Each first cable 13 has five wires that are electrically connected to the two-way switches 26-1, 26-2, 26-3, 26-4, and 26-5 in the corresponding group of two-way switches 26, four wires that are electrically connected to the grounding switches 25-1, 25-2, 25-3, and 25-4 in the corresponding group of grounding switches 25, and one wire that is electrically connected to both the communication line 172 of the electrode sheet 10 and the communication transmission line 211 of the adapter 20. That is, each first connector 40 is electrically connected one-to-one with a corresponding set of bidirectional switches 26 of the adapter 20, a corresponding set of grounding switches 25, and a corresponding communication transmission line 211 connected to the first controller 22 through 10 wires; and is connected to the electric field generator 30 through a corresponding AC signal line 28 of the adapter 20.

[0106] A second connector 50 is provided between the adapter 20 and the electric field generator 30. The second connector 50 is suitable for connecting the electric field generator 30 to the adapter 20. The adapter 20 also includes a second cable 21 connected to the second connector 50. The second connector 50 includes a second plug 51 provided at the end of the second cable 21 away from the first controller 22, and a second socket 52 provided on the electric field generator 30. The second plug 51 and the second socket 52 are press-type spring connectors, that is, the second connector 50 uses a connector method to connect the adapter 20 and the electric field generator 30. Each first connector 40, such as X1, Y1, X2, and Y2, is connected to the second connector 50 via a corresponding AC signal line 28. The first connectors 40, such as X1, Y1, X2, and Y2, are respectively connected to a corresponding set of grounding switches 25, a corresponding set of analog-to-digital converters 23, and a corresponding communication transmission line 211. Each first connector 40 is connected to the second connector 50 and the corresponding set of analog-to-digital converters 23 via a corresponding set of bidirectional switches 26. Taking four electrode pads 10 as an example, the second cable 21 has eight conductors, including four conductors 1 to 4 that are electrically connected to the corresponding AC signal lines 28 and used to transmit alternating current signals, a conductor 5 that is electrically connected to the data receiving line RX of the first communication unit 27, a conductor 6 that is electrically connected to the data transmitting line TX of the first communication unit 27, a conductor 7 that is electrically connected to the VCC power line of the first power module 29, and a conductor 8 that is electrically connected to the GND line of the first power module 29. The second connector 50 is connected to the first communication unit 27 through the data receiving line RX and the data sending line TX. The VCC pin of the second connector 50 is connected to the VCC power line of the first power module 29. The GND pin of the second connector 50 is connected to the GND line of the first power module 29 and is grounded. The VCC pin of the second connector 50 is also connected to the corresponding group of voltage dividers 24 and the corresponding group of analog-to-digital converters 23 through the VCC power line of the first power module 29.

[0107] refer to Figure 5The electric field generator 30 includes a second power module 31, a second controller 32, an AC signal generator 34, a second communication unit 33, and a set of AC signal switches 35. The VCC pin of the second connector 50 is also electrically connected to the VCC power line of the second power module 31, and the GND pin of the second connector 50 is grounded via the GND line of the second power module 31. The second power module 31 is also connected to the second controller 32 and the AC signal generator 34, respectively, and provides power to them. The second communication unit 33 is electrically connected to the wire 5 of the second connector 50 via its data receiving line RX and to the wire 6 of the second connector 50 via its data transmitting line TX, thereby enabling information exchange between the electric field generator 30 and the adapter 20. The second controller 32 is also electrically connected to the second communication unit 33, the AC signal generator 34, and a set of AC signal switches 35. The second controller 32 is configured to control the opening and closing of each AC signal switch 35 in the set of AC signal switches 35 and adjust the parameters of the AC signal applied by the AC signal generator 34 based on the relevant digital signals received by the second communication unit 33 from the adapter 20. The relevant parameters of the AC signal include the voltage, current, and power of the AC signal. The AC signal generator 34 is electrically connected to the plurality of conductors 1, 2, 3, and 4 of the second connector 50 that transmit the AC signal through the set of AC signal switches 35. The set of AC signal switches 35 includes a plurality of AC signal switches 35, each of which is provided in a one-to-one correspondence with the plurality of electrode sheets 10. Each AC signal switch 35 is electrically connected to a corresponding conductor 1, 2, 3, or 4 of the second connector 50 that transmits the AC signal through an AC signal connection 36, and is electrically connected to the corresponding electrode sheet 10 through the corresponding conductor 1, 2, 3, or 4 of the second connector 50, thereby transmitting the AC signal to each electrode sheet 10. The AC signal generator 34 is electrically connected to the set of AC signal switches 35 through a set of AC signal connections 36 .

[0108] Specifically, the number of AC signal switches 35 of the electric field generator 30 is related to the number of electrode sheets 10. In this embodiment, the number of AC signal switches 35 is equal to the number of electrode sheets 10, and both are four. The AC signal switches 35 include a first AC signal switch 35-1, a second AC signal switch 35-2, a third AC signal switch 35-3, and a fourth AC signal switch 35-4, which are electrically connected to the wires 1 to 4 of the second connector 50 in a one-to-one correspondence, respectively.One end of the first AC signal switch 35-1 is electrically connected to the AC signal generator 34 through the first AC signal connection 36 of the electric field generator 30, and the other end is electrically connected to the corresponding conductor 1 for transmitting AC signals in the second connector 50 through the first AC signal connection 36-1 and electrically connected to the AC signal line 28 at the port X1 of the adapter 20 through the conductor 1 of the second connector 50, the AC signal line 28 at the port X1 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port X1 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits AC signals to the electrode sheet 10 electrically connected to the port X1 of the adapter 20; One end of the second AC signal switch 35-2 is electrically connected to the AC signal generator 34 through the second AC signal connection 36 of the electric field generator 30, and the other end is electrically connected to the corresponding conductor 2 for transmitting AC signals in the second connector 50 through the second AC signal connection 36-2 and electrically connected to the AC signal line 28 at the port Y1 of the adapter 20 through the conductor 2 of the second connector 50, the AC signal line 28 at the port Y1 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port Y1 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits AC signals to the electrode sheet 10 electrically connected to the port Y1 of the adapter 20; the second AC signal switch 35-2 One end of the third AC signal switch 35-3 is electrically connected to the AC signal generator 34 through the third AC signal connection 36-3 of the electric field generator 30, and the other end is electrically connected to the corresponding wire 3 for transmitting AC signals in the second connector 50 through the AC signal connection 36-3 and electrically connected to the AC signal line 28 at the port X2 of the adapter 20 through the wire 3 of the second connector 50, the AC signal line 28 at the port X2 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port X2 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits AC signals to the electrode sheet 10 electrically connected to the port X2 of the adapter 20; the fourth One end of the AC signal switch 35-4 is electrically connected to the AC signal generator 34 through the fourth AC signal connection 36-4 of the electric field generator 30, and the other end is electrically connected to the corresponding conductor 4 for transmitting AC signals in the second connector 50 through the fourth AC signal connection 36-4 and electrically connected to the AC signal line 28 at the port Y2 of the adapter 20 through the conductor 4 of the second connector 50, the AC signal line 28 at the port Y2 of the adapter 20 is electrically connected to the first connector 40, and the first connector 40 at the port Y2 of the adapter 20 is electrically connected to the corresponding electrode sheet 10, so as to control whether the AC signal generator 34 transmits AC signals to the electrode sheet 10 electrically connected to the port Y1 of the adapter 20.

[0109] The working principle of the handshake chip 17 is described in detail as follows. The handshake chip 17 can store electrical energy through an external energy storage element (not shown) when the communication line 172 transmits a high level, and release energy when the communication line 172 transmits a low level, so that the handshake chip 17 obtains sufficient power and operates normally. Optionally, the energy storage element is a capacitor. In this way, the handshake chip 17 only needs an additional core wire for communication to operate normally. The handshake chip 17 is suitable for handshake communication with an external device such as an electric field generator 30 or an adapter 20 to determine the connection status of each pair of electrode sheets 10, wherein, after the handshake chip 17 completes the handshake communication with the adapter 20 and / or the electric field generator 30, by combining the configuration of the state of the bidirectional switching switch 26 and the grounding switch 25, the electrode sheet 10 can be applied with an AC signal or temperature acquisition can be performed. When the electrode sheet 10 needs to collect or measure temperature, all bidirectional switches 26 on the flexible circuit board 11 of the electrode sheet 10 are located at the sampling end 1. The electric field generator 30 or the adapter 20 can sequentially close each grounding switch 25, so that the analog temperature signals of the corresponding temperature sensors 14 in each row group are sampled simultaneously at the corresponding temperature sampling points. The analog temperature signals detected by each sampled temperature sensor 14 can also be converted into a type that can be used to characterize the electrode sheet 10 if the electrode sheet 10 is qualified, and can also be used to indicate whether the electrode sheet 10 has temperature anomalies.

[0110] Specifically, upon receiving the handshake signal sent by the electric field generator 30, the first controller 22 of the adapter 20 controls the corresponding grounding switch 25 connected to the ground pin of the handshake chip 17 to close, thereby powering on the handshake chip 17 and sending the handshake signal to the handshake chip 17. The handshake chip 17 sends a feedback signal, and the first controller 22 on the adapter 20 sends the feedback signal of the handshake chip 17 to the second controller 32 of the electric field generator 30 through the second connector 50. The second controller 32 determines whether the corresponding first controller 22 and the handshake chip 17 have completed handshake communication based on the feedback signal of the handshake chip 17. After the handshake communication is completed, the second controller 32 configures the states of the grounding switches 25 and the bidirectional switches 26 in the switch unit (unnumbered) on the adapter 20 to transmit an AC signal to the dielectric element of each electrode unit 12 of the electrode sheet 10 or to measure the temperature through the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10. When the electrode sheet 10 is in the temperature collection state, the electric field generator 30 controls each bidirectional switch 26 of the adapter 20 through its second controller 32 so that each bidirectional switch 26 is at its respective collection end 1, and closes each grounding switch 25 in sequence, so that each detection channel of the corresponding analog-to-digital converter 23 collects temperature detection signals from each temperature sensor 14 in a row, and performs analog-to-digital conversion on the obtained temperature analog signals to obtain a plurality of AD sampling values, which correspond to digital temperatures. The first controller 22 can also send the plurality of AD sampling values ​​to the electric field generator 30 through the adapter 20 so that if the electrode sheet 10 is qualified, the electric field generator 30 can identify the type of the corresponding electrode sheet 10 based on the plurality of AD sampling values, and / or, in the process of transmitting the alternating electrical signal to the corresponding electrode sheet 10, determine whether the corresponding electrode sheet 10 has a temperature abnormality based on the plurality of AD sampling values.

[0111] The following will refer to Figures 3 to 5 The working principle of the tumor electric field treatment system 100 of this embodiment is described in detail.

[0112] The second controller 32 of the electric field generator 30 controls the grounding switch 25-4 corresponding to the fourth grounding line 18-4 connected to the handshake chip 17 of the electrode sheet 10 to be in a closed state through the first controller 22 of the adapter 20, and sends a handshake signal to the communication line 172 of the electrode sheet 10 through the first controller 22. The connection status between the electrode sheet 10 and the adapter 20 is determined based on whether feedback from the handshake chip 17 is received. If the electric field generator 30 can receive a feedback signal from the electrode sheet 10, it indicates that the connection between the electrode sheet 10 and the adapter 20 is normal; an alternating current signal can then be applied to the electrode sheet 10 or a temperature detection signal can be collected through the temperature sensor 14 of the electrode sheet 10. If the electric field generator 30 does not receive a feedback signal from the electrode sheet 10, it indicates that the connection between the electrode sheet 10 and the adapter 20 is abnormal, and the second controller 32 of the electric field generator 30 issues a connection abnormality prompt to alert the operator. After the operator handles the process, the second controller 32 continues to control the first controller 22 of the adapter 20 to send a handshake communication signal to the handshake chip 17 of the electrode sheet 10, and repeats the above-mentioned operation of judging the connection status of the electrode sheet 10 until the electrode sheet 10 and the adapter 20 are connected normally.

[0113] When the electrode sheet 10 is connected normally and the temperature of each electrode unit 12 of a certain electrode sheet 10 needs to be detected, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls the sampling end 1 of each of the multiple bidirectional switching switches 26 of a group of bidirectional switching switches 26 electrically connected to the electrode sheet 10 to be turned on and the input end 2 to be disconnected, so as to disconnect the AC signal applied to the electrode sheet 10; at the same time, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls each of the grounding switches 25 in a group of grounding switches 25 electrically connected to the electrode sheet 10 to be turned on in sequence. At this time, the temperature detection signals collected by each temperature sensor 14 of each electrode unit 12 of each row group of the electrode sheet 10 can be collected in sequence through multiple detection channels A, B, C, D, and E of a group of analog-to-digital converters 23 corresponding to the electrode sheet 10. Each detection channel A, B, C, D, and E of each group of analog-to-digital converters 23 only collects the temperature detection signal of the temperature sensor 14 corresponding to the electrode unit 12 in each electrode unit 12 of the electrode sheet 10 in the same row group at the same time. The above-mentioned temperature detection signal can be represented by a voltage value. Among the four grounding switches 25 in a group of grounding switches 25 corresponding to the electrode sheet 10, only one grounding switch 25 can be turned on at the same time, and the other three are turned off. The five bidirectional switching switches 26 in a group of bidirectional switching switches 26 corresponding to the group of analog-to-digital converters 23 are all switched to their respective sampling terminals 1 so that the dual-purpose signal lines 19 of the electrode sheet 10 are electrically connected to the corresponding detection channels A, B, C, D, and E of the corresponding analog-to-digital converters 23 in a one-to-one correspondence and turned on. With this arrangement, the group of analog-to-digital converters 23 can collect the voltage values ​​of all temperature sensors 14 of each electrode unit 12 in the same row group that are short-circuited with the grounding line 18 corresponding to the turned-on grounding switch 25.

[0114] Specifically, when the first grounding switch 25-1 is closed, the second grounding switch 25-2, the third grounding switch 25-3 and the fourth grounding switch 25-4 are all opened, and the first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4 and the fifth bidirectional switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-1 to 12-5 of the first row group are powered on, and the temperature sensors 14 of the electrode units 12-6 to 12-20 of the remaining row groups are powered off, and the electrode units 12-1, 12-6, 12-11 and 12-16 are short-circuited on the first detection channel A of the analog-to-digital converter 23 of the group. Regarding the signal terminal 14-2 of the temperature sensor 14, only the ground terminal 14-1 of the temperature sensor 14 of electrode unit 12-1 is connected to ground, while the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-6, 12-11, and 12-16 are disconnected. Furthermore, each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14. The remaining temperature sensors 14 in the first row do not affect the resistance of the temperature sensor 14 of electrode unit 12-1. Therefore, only the temperature sensor 14 of electrode unit 12-1 is effectively operating on the first detection channel A of the set of analog-to-digital converters 23. The temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of electrode unit 12-1. Similarly, the voltage value collected by the second detection channel B of the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-2. The voltage value collected by the third detection channel C of the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-3. The voltage value collected on the fourth detection channel D of the ADC 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-4. The voltage value collected on the fifth detection channel E of the ADC 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-5.

[0115] When the second grounding switch 25-2 is closed, the first grounding switch 25-1, the third grounding switch 25-3 and the fourth grounding switch 25-4 are all opened, and the first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4 and the fifth bidirectional switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-6 to 12-10 of the second row group are powered on, and the temperature sensors 14 of the electrode units 12-1 to 12-5 and the electrode units 12-11 to 12-20 of the remaining row groups are powered off, and the electrode units 12-1, 12-6, 12-11 and 12-20 of the first detection channel A of the analog-to-digital converter 23 of the group are short-circuited. Since only the ground terminal 14-1 of the temperature sensor 14 of electrode unit 12-6 is connected to the ground, and the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-1, electrode units 12-11, and electrode units 12-16 are all disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, the remaining temperature sensors 14 in the second row will not affect the resistance value of the temperature sensor 14 of electrode unit 12-6. Therefore, only the temperature sensor 14 of electrode unit 12-6 is effectively operating on the first detection channel A of the group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of electrode unit 12-6. Similarly, the voltage value collected by the second detection channel B in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-7. The voltage value collected by the third detection channel C in the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-8. The voltage value collected by the fourth detection channel D in the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-9. The voltage value collected by the fifth detection channel E in the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-10.

[0116] When the third grounding switch 25-3 is closed, the first grounding switch 25-1, the second grounding switch 25-2 and the fourth grounding switch 25-4 are all opened, and the first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4 and the fifth bidirectional switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-11 to 12-15 of the third row group are powered on, and the temperature sensors 14 of the electrode units 12-1 to 12-10 and the electrode units 12-16 to 12-20 of the remaining row groups are powered off, and the electrode units 12-1, 12-6, 12-11, and 12-20 of the first detection channel A of the analog-to-digital converter 23 of the group are short-circuited. Since only the ground terminal 14-1 of the temperature sensor 14 of electrode unit 12-11 is connected to the ground, and the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-1, electrode units 12-6, and electrode units 12-16 are all disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, the remaining temperature sensors 14 in the third row will not affect the resistance value of the temperature sensor 14 of electrode unit 12-11. Therefore, only the temperature sensor 14 of electrode unit 12-11 is effectively operating on the first detection channel A of the group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of electrode unit 12-11. Similarly, the voltage value collected by the second detection channel B in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of electrode unit 12-12. The voltage value collected by the third detection channel C in the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode units 12-13. The voltage value collected by the fourth detection channel D in the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode units 12-14. The voltage value collected by the fifth detection channel E in the set of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode units 12-15.

[0117] When the fourth grounding switch 25-4 is closed, the first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 are all opened, and the first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4, and the fifth bidirectional switch 26-5 are all switched to their respective sampling terminals 1, the temperature sensors 14 of the electrode units 12-16 to 12-20 of the fourth row group are powered on, and the temperature sensors 14 of the electrode units 12-1 to 12-15 of the remaining row groups are powered off, and the temperature sensors 14 of the electrode units 12-1 to 12-15 of the first detection channel A of the analog-to-digital converter 23 of the group are short-circuited. As for the signal end 14-2 of the sensor 14, since only the ground end 14-1 of the temperature sensor 14 of the electrode unit 12-16 is connected to the ground, and the ground ends 14-1 of the temperature sensors 14 of the electrode units 12-1, 12-6, and 12-11 are disconnected, and each electrode unit 12 is provided with a diode 16 connected in series with the temperature sensor 14, the remaining temperature sensors 14 in the fourth row will not affect the resistance value of the temperature sensor 14 of the electrode unit 12-16. Therefore, only the temperature sensor 14 of the electrode unit 12-16 is effectively operating on the first detection channel A of the group of analog-to-digital converters 23. At this time, the temperature detection signal (voltage value) collected by the first detection channel A is the voltage value of the temperature sensor 14 of the electrode unit 12-16. Similarly, the voltage value collected by the second detection channel B of the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-17. The voltage value collected on the third detection channel C in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-18. The voltage value collected on the fourth detection channel D in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-19. The voltage value collected on the fifth detection channel E in the group of analog-to-digital converters 23 is the voltage value of the temperature sensor 14 of the electrode unit 12-20. Thus, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 can realize the collection of temperature detection signals of the temperature sensors 14 of all electrode units 12 of a certain electrode sheet 10 by controlling a group of bidirectional switching switches 26 and a group of grounding switches 25 that are electrically connected to the electrode sheet 10. Similarly, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 of other electrode sheets 10 can be obtained.

[0118] The first controller 22, the plurality of analog-to-digital converters 23, and the plurality of bidirectional switches 26 can automatically perform operations according to pre-programmed program codes. For example, the first controller 22 first controls all the bidirectional switches 26 in the corresponding group of bidirectional switches 26 to switch to the sampling terminal 1, so that the sampling terminals 1 of the bidirectional switches 26 are all turned on and the input terminals 2 are all turned off, so that the dual-purpose signal lines 19 of the corresponding electrode sheets 10 are electrically connected to the corresponding group of analog-to-digital converters 23. Then, the first grounding switch 25-1 in the corresponding group of grounding switches 25 is closed, and the remaining second grounding switches 25-2, third grounding switches 25-3 to fourth grounding switches 25-4 in the group of grounding switches 25 are turned off. During this period, the group Each detection channel A, B, C, D, and E of the analog-to-digital converter 23 acquires the temperature detection signals of each temperature sensor 14 of each electrode unit 12 located in the first row group of the corresponding electrode sheet 10, converts them into digital signals, and stores them in a separately provided memory. Then, after a preset interval, the first controller 22 closes the second grounding switch 25-2 in the group of grounding switches 25 and opens the first grounding switch 25-1, the third grounding switch 25-3, and the fourth grounding switch 25-4 in the group of grounding switches 25. During this period, each detection channel A, B, C, D, and E of the analog-to-digital converter 23 acquires the temperature detection signals of each temperature sensor 14 of each electrode unit 12 located in the second row group. By sequentially opening each grounding switch 25 in the group of grounding switches 25, the temperature detection signals of all temperature sensors 14 located in each row group of the electrode sheet 10 can be obtained. Similarly, through this operation, the temperature detection signals of all temperature sensors 14 on at least one pair of electrode sheets 10 are obtained.

[0119] The tumor electric field therapy system 100 of the present application can realize real-time and comprehensive monitoring of the temperature of all electrode units 12 on the electrode sheet 10 without increasing the weight of the electrode sheet 10 or adding the core of the first cable 13 electrically connected to the electrode sheet 10, and then determine whether the electrode sheet 10 is qualified based on the obtained temperature detection signal; or determine whether the temperature sensor 14 of the electrode sheet 10 is faulty or abnormal based on the obtained temperature detection signal, and determine whether the electrode sheet 10 needs to be replaced based on the number of faulty or abnormal temperature sensors 14 obtained; or if the electrode sheet is qualified, identify the type of electrode sheet based on the obtained temperature detection signal; or if the electrode sheet is qualified, determine whether the electrode unit 12 of the electrode sheet 10 is overheated based on the obtained temperature detection signal, and then control the alternating electric signal applied to the electrode sheet 10 or the electrode unit 12 of the corresponding column of the electrode sheet 10, so as to avoid low-temperature burns on the patient's body surface when tumor treatment is performed through the electrode sheet 10. In addition, the flexible circuit board 11 of the electrode sheet 10 of the present application is electrically connected to the dielectric element 15 of the same electrode unit 12 and the signal terminal 14-2 of the temperature sensor 14 through the same dual-purpose signal line 19. While it can transmit both an AC signal and a DC signal for temperature signal acquisition and the collected temperature detection signal through the dual-purpose signal line 19, it also greatly reduces the number of conductive traces (grounding line 18, dual-purpose signal line 19) arranged thereon, thereby reducing the wiring difficulty of the flexible circuit board 11, simplifying the manufacturing process, reducing the weight of the flexible circuit board 11, and reducing manufacturing costs. The electrode sheet 10 of the present application can also switch between applying an AC signal for tumor treatment and transmitting a DC signal for temperature acquisition and the collected temperature detection signal through the combined control of a grounding switch 25 electrically connected to the grounding line 18 arranged thereon and a bidirectional switching switch 26 electrically connected to the dual-purpose signal line 19.

[0120] When the electrode sheet 10 is connected normally and an alternating current signal needs to be applied to the patient through each electrode unit 12 of a certain electrode sheet 10, the first controller 22 of the adapter 20 or the second controller 32 of the electric field generator 30 controls all the grounding switches 25 in a group of grounding switches 25 corresponding to the electrode sheet 10 to be disconnected, and at the same time controls all the bidirectional switching switches 26 in a group of bidirectional switching switches 26 corresponding to the electrode sheet 10 to be switched to their respective input ends 2, so that the sampling ends 1 of the bidirectional switching switches 26 are all disconnected and the input ends 2 are all turned on, so that all the dual-purpose signal lines 19 of the electrode sheet 10 are electrically connected to an AC signal line 28 corresponding to the adapter 20 and the electrode sheet 10, thereby transmitting the alternating current signal to each electrode unit 12 of the electrode sheet 10.When the temperature detection signals of the temperature sensors 14 of all the electrode units 12 of the electrode sheet 10 are much lower than the preset temperature threshold stored in the electric field generator 30 or the adapter 20, the electric field generator 30 controls the AC signal generator 34 through its second controller 32 to continue to generate an AC signal with an increased voltage or current amplitude or a constant voltage or current amplitude, and then transmits it to the corresponding pair of electrode sheets 10 through a corresponding AC signal line 28 of the adapter 20, so that the pair of electrode sheets 10 continue to apply the AC signal; when the temperature detection signals of the temperature sensors 14 of all the electrode units 12 of the electrode sheet 10 are lower than but close to the preset temperature threshold stored in the electric field generator 30 or the adapter 20, The electric field generator 30 can reduce the voltage or current of the alternating current signal generated by the AC signal generator 34 through the second controller 32, thereby reducing the voltage or current of the alternating current signal applied to the pair of electrode sheets 10; when it is detected that the temperature detection signal of the temperature sensor 14 of an electrode unit 12 in a certain electrode sheet 10 is greater than a preset temperature threshold, the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode sheet 10 to be disconnected through the second controller 32 to stop applying the alternating current signal to the electrode sheet 10; or the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls all the bidirectional switches in a group of bidirectional switches 26 electrically connected to the electrode sheet 10 The switches 26 are all switched from their input terminals 2 to the sampling terminals 1, that is, all the sampling terminals 1 of the two-way switching switches 26 electrically connected to the electrode sheet 10 are turned on and all the input terminals 2 are turned off, thereby temporarily stopping the application of the alternating electric signal to the electrode sheet 10; or, when it is detected that the temperature detection signal of the temperature sensor 14 of an electrode unit 12 of a certain electrode sheet 10 is greater than the preset temperature threshold, the second controller 32 of the electric field generator 30 controls the AC signal switch 35 electrically connected to the electrode sheet 10 to continue to be turned on, and the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 controls a two-way switch electrically connected to the electrode unit 12 of the electrode sheet 10 to continue to be turned on. Switch 26 switches from its input terminal 2 to its sampling terminal 1, and the second controller 32 of the electric field generator 30 or the first controller 22 of the adapter 20 simultaneously controls the input terminals 2 of the remaining bidirectional switches 26 electrically connected to the electrode units 12 of the electrode sheet 10 whose temperature detection signals do not exceed the preset temperature threshold and are in different columns from the electrode units 12 whose temperature detection signals exceed the preset temperature threshold to continue to maintain electrical connection, thereby stopping the application of the AC signal to all electrode units 12 in the column of the electrode unit 12 of the electrode sheet 10 whose temperature detection signals exceed the preset temperature threshold, and continuing to apply the AC signal to the electrode units 12 in the remaining columns of the electrode sheet 10 whose temperature detection signals do not exceed the preset temperature threshold. This implements the control method of the tumor electric field therapy system 100 for regional application of the AC signal based on the temperature detection signal.When an AC signal is applied, all grounding switches 25 are opened.

[0121] In the embodiment of the present application, the grounding switch 25 electrically connected to each of the multiple grounding lines 18 of the electrode sheet 10 and the bidirectional switch 26 electrically connected to each of the multiple dual-purpose signal lines 19 of the electrode sheet 10 are both provided in the adapter 20. However, in other embodiments, the grounding switch 25 electrically connected to the grounding line 18 and the bidirectional switch 26 electrically connected to the dual-purpose signal line 19 can also be provided on the electrode sheet 10 or provided in the electric field generator 30, which will not be described in detail here. In addition, the analog-to-digital converter 23 provided in the adapter 20 can also be provided in the electric field generator 30 and directly controlled by the second controller 32.

[0122] The present application also provides other embodiments of the electrode sheet 10 . The differences among the multiple embodiments mainly lie in the different numbers of electrode units 12 and / or the different circuit distribution methods of the electrode units 12 , which will be described below.

[0123] Figure 6 This is a circuit connection diagram of the tumor electric field treatment system according to the second embodiment of the present application, showing the electrode sheet 10D of the second embodiment and Figure 1 , which is a schematic diagram of the circuit connection of the adapter 20 of the first embodiment. The following describes the circuit by taking the electrode sheet 10D in the second embodiment as an example. In terms of electrical connection, the difference between the electrode sheet 10D and the electrode sheet 10 of the first embodiment lies in the number of electrode units 12 and the circuit arrangement. The electrode sheet 10D in this embodiment has 13 aforementioned electrode units 12. In terms of electrical connection, the flexible circuit board 11D of the electrode sheet 10D arranges these 13 electrode units 12 into three rows and five columns on the circuit, wherein two rows each have five electrode units 12, and the remaining row has three electrode units 12. The flexible circuit board 11D of the electrode sheet 10D is embedded with three grounding wires 18, five dual-purpose signal wires 19, one ground trace 171 connected to the ground pin of the handshake chip 17 and any one ground wire 28 at the same time, and one communication wire 172 connected to the communication pin of the handshake chip 17. Each ground line 18 is used to connect the ground terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in a corresponding row group to ground. Each dual-purpose signal line 19 short-circuits the dielectric element 15 of each electrode unit 12 and the signal terminal 14-2 of each temperature sensor 14 in each column group, respectively, for receiving temperature detection signals or transmitting AC signals. A ground line 18 connected to the ground trace 171 also connects the ground pin of the handshake chip 17 to ground.

[0124] The three grounding lines 18 of the flexible circuit board 11D are a first grounding line 18-1, a second grounding line 18-2, and a third grounding line 18-3. Of the three row groups of the electrode sheet 10D, the first row group includes electrode units 12-1 to 12-5, the second row group includes electrode units 12-6 to 12-10, and the third row group includes electrode units 12-11 to 12-13. Specifically, first ground line 18-1 is used to connect the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-1 to 12-5 in the first row group to ground; second ground line 18-2 is used to connect the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-6 to 12-10 in the second row group to ground; third ground line 18-3 is used to connect the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-11 to 12-13 in the third row group to ground, and is also used to connect the ground pin of handshake chip 17 to ground via ground trace 171 connected to the ground pin of handshake chip 17. In short, each ground line 18 short-circuits the ground terminals 14-1 of the temperature sensors 14 of all electrode units 12 in the corresponding row group to ground, and one of the ground lines 18 also short-circuits the ground pin of handshake chip 17 to ground.

[0125] The five dual-purpose signal lines 19 of the electrode sheet 10D include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric elements 15 of the three electrode units 12, namely, the electrode unit 12-1, the electrode unit 12-6, and the electrode unit 12-11, and the signal end 14-2 of the temperature sensor 14 of each; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric elements 15 of the three electrode units 12, namely, the electrode unit 12-2, the electrode unit 12-7, and the electrode unit 12-12, and the signal end 14-2 of the temperature sensor 14 of each; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the electrode unit 12-3, the electrode unit 12-6, and the electrode unit 12-11, and the signal end 14-2 of the temperature sensor 14 of each The fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the three electrode units 12 (electrode units 12-8 and 12-13) and the signal terminals 14-2 of the temperature sensors 14. One end of the fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the two electrode units 12 (electrode units 12-4 and 12-9) and the signal terminals 14-2 of the temperature sensors 14. One end of the fifth dual-purpose signal line 19-5 is connected to the dielectric elements 15 of the two electrode units 12 (electrode units 12-5 and 12-10) and the signal terminals 14-2 of the temperature sensors 14. In short, each dual-purpose signal line 19 parallel-circuits the dielectric elements 15 and the signal terminals 14-2 of the temperature sensors 14 of the electrode units 12 in the corresponding column group and is used to connect to the adapter 20.

[0126] The first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 on the adapter 20 are electrically connected to the first grounding line 18-1, the second grounding line 18-2, and the third grounding line 18-3 of the electrode sheet 10D, respectively, via a first connector 40D. The fourth grounding switch 25-4 is in an idle and disconnected state. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4, and the fifth bidirectional switch 26-5 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5 of the electrode sheet 10D, respectively, via a first connector 40D. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172 connected to the communication pin of the handshake chip 17 of the electrode sheet 10D.

[0127] The working mode of the tumor electric field therapy system formed by the electrode sheet 10D, the adapter 20 and the electric field generator 30 is the same as that of the aforementioned tumor electric field therapy system 100. The second controller 32 of the electric field generator 30 sends a handshake communication signal to the first controller 22 of the adapter 20, and the third grounding switch 25-3 electrically connected to the handshake chip 17 of the electrode sheet 10 is closed through the first controller 22 of the adapter 20 or directly controlled, and the handshake chip 17 is powered on. At this time, the first controller 22 sends a handshake communication signal to the handshake chip, and confirms that the electrode sheet 10 is connected normally after receiving the feedback signal from the handshake chip 17. When no feedback signal from the handshake chip 17 is received, it confirms that the electrode sheet 10 is connected abnormally. When the electrode sheet 10 is properly connected, the electric field transmitter 30 or adapter 20 controls all grounding switches 25 to be disconnected, and the input terminals 2 of all bidirectional switches 26 to be conductive, while the sampling terminals 1 are disconnected, so that all dual-purpose signal lines 19 and AC signal lines 28 are conductive. At this point, all electrode units 12 of the electrode sheet 10 can receive AC signals. 2) By connecting the sampling terminals 1 of all bidirectional switches 26 and disconnecting the input terminals 2, and sequentially connecting each grounding switch 25, the temperature detection signals of the temperature sensors 14 of each electrode unit 12 in each row group of the electrode sheet 10 can be obtained. No operation is required for the grounding switches 25 that are in an idle and disconnected state.

[0128] refer to Figure 7 FIG. 1 is a circuit connection diagram of the tumor electric field therapy system according to the third embodiment of the present application, showing the electrode sheet 10E of the third embodiment and Figure 1 , a circuit connection diagram of the adapter 20 is shown in FIG. This electrode sheet 10E, like the electrode sheet 10D in the second embodiment, is provided with 13 electrode units 12, but the specific circuit arrangement is different. The flexible circuit board 11E of the electrode sheet 10E also arranges these 13 electrode units 12 into three rows and five columns, except that two rows each have four electrode units 12, and the remaining row has five electrode units 12. The flexible circuit board 11E of the electrode sheet 10E is also embedded with three ground lines 18, five dual-purpose signal lines 19, a ground trace 171 connected to both the ground pin of the handshake chip 17 and any one of the ground lines 28, and a communication line 172 connected to the communication pin of the handshake chip 17. Each ground line 18 is used to connect the ground terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in a corresponding row group to ground. Each dual-purpose signal line 19 short-circuits the dielectric element 15 of each electrode unit 12 and the signal terminal 14-2 of each temperature sensor 14 in each column group, respectively, for receiving temperature detection signals or transmitting AC signals. A ground line 18 connected to the ground trace 171 also connects the ground pin of the handshake chip 17 to ground.

[0129] The three grounding lines 18 of the electrode sheet 10E include a first grounding line 18-1, a second grounding line 18-2, and a third grounding line 18-3. The first row group includes electrode units 12-1 to 12-4, the second row group includes electrode units 12-5 to 12-8, and the third row group includes electrode units 12-9 to 12-13. Specifically, the first grounding line 18-1 is used to ground the grounding ends 14-1 of the temperature sensors 14 of the electrode units 12-1 to 12-4 in the first row group; the second grounding line 18-2 is used to ground the grounding ends 14-1 of the temperature sensors 14 of the electrode units 12-5 to 12-8 in the second row group; and the third grounding line 18-3 is used to ground the grounding ends 14-1 of the temperature sensors 14 of the electrode units 12-9 to 12-13 in the third row group and to ground the ground pin of the handshake chip 17 through the ground trace 171 connected to the ground pin of the handshake chip 17. In short, each ground line 18 short-circuits the ground terminals 14 - 1 of the temperature sensors 14 of all electrode units 12 in each row group and connects them to ground. One of the ground lines 18 also short-circuits the ground pin of the handshake chip 17 to ground.

[0130] The five dual-purpose signal lines 19 of the electrode sheet 10E include a first dual-purpose signal line 19-1, a second dual-purpose signal line 19-2, a third dual-purpose signal line 19-3, a fourth dual-purpose signal line 19-4, and a fifth dual-purpose signal line 19-5. One end of the first dual-purpose signal line 19-1 is simultaneously connected to the dielectric elements 15 of the three electrode units 12, the electrode unit 12-1, the electrode unit 12-5, and the electrode unit 12-9, and the signal end 14-2 of the temperature sensor 14 of each; one end of the second dual-purpose signal line 19-2 is simultaneously connected to the dielectric elements 15 of the three electrode units 12, the electrode unit 12-2, the electrode unit 12-6, and the electrode unit 12-10, and the signal end 14-2 of the temperature sensor 14 of each; one end of the third dual-purpose signal line 19-3 is simultaneously connected to the dielectric elements 15 of the three electrode units 12, the electrode unit 12-6, and the electrode unit 12-10, and the signal end 14-2 of the temperature sensor 14 of each The fourth dual-purpose signal line 19-4 connects the dielectric elements 15 of the three electrode units 12 (electrode units 12-3, 12-7, and 12-11) and the signal terminals 14-2 of their respective temperature sensors 14. One end of the fourth dual-purpose signal line 19-4 is connected simultaneously to the dielectric elements 15 of the three electrode units 12 (electrode units 12-4, 12-8, and 12-12) and the signal terminals 14-2 of their respective temperature sensors 14. One end of the fifth dual-purpose signal line 19-5 is connected simultaneously to the dielectric element 15 of the electrode unit 12-13 and the signal terminal 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 parallel-circuits the dielectric elements 15 and the signal terminals 14-2 of the temperature sensors 14 of each electrode unit 12 in a corresponding column group and connects them to the adapter 20.

[0131] The first grounding switch 25-1, the second grounding switch 25-2, and the third grounding switch 25-3 on the adapter 20 are electrically connected to the first grounding line 18-1, the second grounding line 18-2, and the third grounding line 18-3 of the electrode sheet 10E, respectively, via the first connector 40E. The fourth grounding switch 25-4 is in an idle and disconnected state. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4, and the fifth bidirectional switch 26-5 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5 of the electrode sheet 10E, respectively, via the first connector 40E. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172 connected to the communication pin of the handshake chip 17 of the electrode sheet 10E.

[0132] The tumor electric field therapy system formed by the electrode sheet 10E, adapter 20, and electric field generator 30 operates in the same manner as the aforementioned tumor electric field therapy system 100. After the electric field generator 30 controls the adapter 20 to complete handshake communication with the handshake chip 17 of the electrode sheet 10E and confirms that the electrode sheet 10E is properly connected, all grounding switches 25 are disconnected, and the input terminals 2 of all bidirectional switches 26 are connected and the sampling terminals 1 are disconnected. All dual-purpose signal lines 19 and AC signal lines 28 are connected, allowing AC signals to be applied to all electrode units 12. When the sampling terminals 1 of all bidirectional switches 26 are connected and the input terminals 2 are disconnected, each grounding switch 25 is sequentially turned on to obtain temperature detection signals from the temperature sensors 14 of each electrode unit 12 in each row group. No operation is required for grounding switches 25 that are in an idle, disconnected state.

[0133] refer to Figure 8As shown, the electrode sheet 10F of the fourth embodiment has 13 electrode units 12, similar to the electrode sheet 10D of the third embodiment, but the specific circuit layout is different. The flexible circuit board 11F of the electrode sheet 10F arranges these 13 electrode units 12 into four rows and four columns. Three rows each have four electrode units 12, and the remaining row has one electrode unit 12. The electrode sheet 10F includes four ground lines 18, four dual-purpose signal lines 19, a ground trace 171 connected to both the ground pin of the handshake chip 17 and any ground line 28, and a communication line 172 connected to the communication pin of the handshake chip 17. Each ground line 18 is used to ground the ground terminal 14-1 of each temperature sensor 14 of each electrode unit 12 in a corresponding row group. Each dual-purpose signal line 19 short-circuits the dielectric element 15 of each electrode unit 12 and the signal terminal 14-2 of each temperature sensor 14 in each column group, thereby receiving temperature detection signals or transmitting AC signals. A ground line 18 connected to the ground trace 171 also connects the ground pin of the handshake chip 17 to ground.

[0134] The four ground lines 18 of the electrode sheet 10F include a first ground line 18-1, a second ground line 18-2, a third ground line 18-3, and a fourth ground line 18-4. The first row group includes electrode units 12-1 through 12-4, the second row group includes electrode units 12-5 through 12-8, the third row group includes electrode units 12-9 through 12-12, and the fourth row group includes electrode unit 12-13. Specifically, first ground line 18-1 is used to connect the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-1 through 12-4 in the first row group to ground; second ground line 18-2 is used to connect the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-5 through 12-8 in the second row group to ground; third ground line 18-3 is used to connect the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-9 through 12-12 in the third row group to ground; and fourth ground line 18-4 is used to connect the ground terminals 14-1 of the temperature sensors 14 of electrode units 12-13 in the fourth row group to ground. Fourth ground line 18-4 is also connected to ground trace 171, which is connected to the ground pin of handshake chip 17. In short, each ground line 18 short-circuits the ground terminals 14-1 of the temperature sensors 14 of all electrode units 12 in each row group to ground, with one ground line 18 also short-circuiting the ground pin of handshake chip 17 to ground.

[0135] The four dual-purpose signal lines 19 of the electrode sheet 10F include a first dual-purpose signal line 19 - 1 , a second dual-purpose signal line 19 - 2 , a third dual-purpose signal line 19 - 3 , and a fourth dual-purpose signal line 19 - 4 . One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the four electrode units 12, namely, electrode unit 12-1, electrode unit 12-5, electrode unit 12-9, and electrode unit 12-13, and the signal end 14-2 of the temperature sensor 14 of each; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the three electrode units 12, namely, electrode unit 12-2, electrode unit 12-6, and electrode unit 12-10, and the signal end 14-2 of the temperature sensor 14 of each; one end of the third dual-purpose signal line 19-3 is connected to the dielectric elements 15 of the three electrode units 12, namely, electrode unit 12-3, electrode unit 12-7, and electrode unit 12-11, and the signal end 14-2 of the temperature sensor 14 of each; one end of the fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the three electrode units 12, namely, electrode unit 12-4, electrode unit 12-8, and electrode unit 12-12, and the signal end 14-2 of the temperature sensor 14 of each. In short, each dual-purpose signal line 19 short-circuits the dielectric elements 15 and the signal terminals 14 - 2 of the temperature sensors 14 of the electrode units 12 in the same column group in parallel and is used to connect to the adapter 20 .

[0136] The first grounding switch 25-1, the second grounding switch 25-2, the third grounding switch 25-3, and the fourth grounding switch 25-4 on the adapter 20 are electrically connected to the first grounding line 18-1, the second grounding line 18-2, the third grounding line 18-3, and the fourth grounding line 18-4 of the electrode sheet 10F, respectively, via a first connector 40F. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, and the fourth bidirectional switch 26-4 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, and the fourth dual-purpose signal line 19-4, respectively, via a first connector 40F. The fifth bidirectional switch 26-5 is in an idle and disconnected state. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172 connected to the communication pin of the handshake chip 17 of the electrode sheet 10F.

[0137] The tumor therapy field system formed by the electrode sheet 10F, adapter 20, and electric field generator 30 operates in the same manner as the aforementioned tumor therapy field system 100. After handshake communication is completed with the first controller 22 of the adapter 20 via the handshake chip 17 and confirmation that the electrode sheet 10F is properly connected, when all grounding switches 25 are disconnected and the input terminals 2 of all bidirectional switches 26 are connected, all dual-purpose signal lines 19 and AC signal lines 28 are connected, and all electrode units 12 receive AC signals. When the sampling terminals 1 of all bidirectional switches 26 are connected, each grounding switch 25 is sequentially turned on to obtain the temperature detection signal of the temperature sensor 14 of each electrode unit 12 in each row group. However, no operation is performed on idle grounding switches 25 and / or idle bidirectional switches 26.

[0138] refer to Figure 9 , which is a schematic diagram of the circuit connection between an electrode sheet and an adapter 20 for another embodiment of the tumor electric field therapy system of the present application. In terms of electrical connection, the electrode sheet 10H in this embodiment differs from the aforementioned electrode sheet in the number of electrode units 12 and the arrangement of the electrode units 12 in the circuit connection. The electrode sheet 10H in this embodiment is provided with nine electrode units 12. The flexible circuit board 11H of the electrode sheet 10H arranges these nine electrode units 12 into two rows and five columns in the circuit connection, with one row having five electrode units 12 and the other row having four electrode units 12. The flexible circuit board 11H of the electrode sheet 10H is embedded with two ground wires 18, five dual-purpose signal wires 19, one ground trace 171 connected to the ground pin of the handshake chip 17 and any one ground wire 28, and one communication line 172 connected to the communication pin of the handshake chip 17. Each ground line 18 is used to ground the ground terminal 14-1 of the temperature sensor 14 of each electrode unit 12 in a corresponding row group. One of the ground lines 18 is also used to ground the ground pin of the handshake chip 17. Each dual-purpose signal line 19 short-circuits the dielectric element 15 of each electrode unit 12 in each column group and the signal terminal 14-2 of each temperature sensor 14 for receiving temperature detection signals or transmitting AC signals.

[0139] The two grounding lines 18 of the electrode sheet 10H are a first grounding line 18-1 and a second grounding line 18-2. Of the two row groups of the electrode sheet 10H, the first row group includes electrode units 12-1 to 12-5, and the second row group includes electrode units 12-6 to 12-9. Specifically, the first grounding line 18-1 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-1 to 12-5 in the first row group; the second grounding line 18-2 is used to ground the grounding terminals 14-1 of the temperature sensors 14 of the electrode units 12-6 to 12-9 in the second row group, and at the same time, ground the ground pin of the handshake chip 17 via a grounding trace 171 connected to the ground pin of the handshake chip 17. In short, each grounding line 18 short-circuits the grounding terminals 14-1 of the temperature sensors 14 of all electrode units 12 in each row group and grounds them, and one of the grounding lines 18 also grounds the ground pin of the handshake chip 17.

[0140] The five dual-purpose signal lines 19 of the electrode sheet 10H include a first dual-purpose signal line 19 - 1 , a second dual-purpose signal line 19 - 2 , a third dual-purpose signal line 19 - 3 , a fourth dual-purpose signal line 19 - 4 , and a fifth dual-purpose signal line 19 - 5 . One end of the first dual-purpose signal line 19-1 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-1 and electrode unit 12-6, and the signal end 14-2 of the temperature sensor 14 of each; one end of the second dual-purpose signal line 19-2 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-2 and electrode unit 12-7, and the signal end 14-2 of the temperature sensor 14 of each; one end of the third dual-purpose signal line 19-3 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-3 and electrode unit 12-8, and the signal end 14-2 of the temperature sensor 14 of each; one end of the fourth dual-purpose signal line 19-4 is connected to the dielectric elements 15 of the two electrode units 12, electrode unit 12-4 and electrode unit 12-9, and the signal end 14-2 of the temperature sensor 14 of each; one end of the fifth dual-purpose signal line 19-5 is connected to the dielectric element 15 of the electrode unit 12-5 and the signal end 14-2 of the temperature sensor 14. In short, each dual-purpose signal line 19 short-circuits the dielectric elements 15 and the signal terminals 14 - 2 of the temperature sensors 14 of the electrode units 12 in a corresponding column group in parallel and is used to connect to the adapter 20 .

[0141] The first grounding switch 25-1 and the second grounding switch 25-2 on the adapter 20 are electrically connected to the first grounding line 18-1 and the second grounding line 18-2 of the electrode sheet 10H, respectively, via the first connector 40H. The third grounding switch 25-3 and the fourth grounding switch 25-4 are in an idle and disconnected state. The first bidirectional switch 26-1, the second bidirectional switch 26-2, the third bidirectional switch 26-3, the fourth bidirectional switch 26-4, and the fifth bidirectional switch 26-5 on the adapter 20 are electrically connected to the first dual-purpose signal line 19-1, the second dual-purpose signal line 19-2, the third dual-purpose signal line 19-3, the fourth dual-purpose signal line 19-4, and the fifth dual-purpose signal line 19-5, respectively, via the first connector 40H. A communication transmission line 211 on the adapter 20 is electrically connected to the communication line 172 connected to the communication pin of the handshake chip 17 of the electrode sheet 10H.

[0142] The tumor therapy field system formed by the electrode sheet 10H, adapter 20, and electric field generator 30 operates in the same manner as the aforementioned tumor therapy field system 100. After the electric field generator 30 controls the adapter 20 to complete handshake communication with the handshake chip 17 of the electrode sheet 10E and confirms that the electrode sheet 10E is properly connected, all grounding switches 25 are disconnected, and the input terminals 2 of all bidirectional switches 26 are connected and the sampling terminals 1 are disconnected. All dual-purpose signal lines 19 and AC signal lines 28 are connected, and all electrode units 12 receive AC signals. When the sampling terminals 1 of all bidirectional switches 26 are connected and the input terminals 2 are disconnected, each grounding switch 25 is sequentially turned on to obtain the temperature detection signal from the temperature sensor 14 of each electrode unit 12 in each row group. No operation is required for grounding switches 25 that are in an idle, disconnected state.

[0143] In the previous embodiment, the adapter 20 has a fixed number of four grounding switches 25 for each electrode sheet 10, 10D, 10E, 10F, and 10H, and a fixed number of five bidirectional switches 26 for each electrode sheet 10, 10D, 10E, 10F, and 10H. This allows for various electrode sheets 10, 10D, 10E, 10F, and 10H with different numbers of electrode units 12. However, in some cases, grounding switches 25 and / or bidirectional switches 26 may be left unused and disconnected, complicating program control. To simplify the control program, specific adapters corresponding to the number of grounding wires 18 and dual-purpose signal wires 19 of the electrode sheet can be provided to avoid the occurrence of grounding switches 25 and / or bidirectional switches 26 left unused and disconnected, facilitating program control. That is, in other embodiments, the number of grounding switches 25 in each group of grounding switches 25 provided on the adapter 20 may be set according to the number of row groups into which the electrode units 12 of the corresponding electrode sheet are divided in circuit connection, or according to the number of grounding lines 18 on the flexible circuit board of the corresponding electrode sheet; the number of bidirectional switching switches 26 in each group of bidirectional switching switches 26 provided on the adapter 20 may be set according to the number of column groups into which the electrode units 12 of the corresponding electrode sheet are divided in circuit connection, or according to the number of dual-purpose signal lines 19 on the flexible circuit board of the corresponding electrode sheet. Preferably, the number of grounding switches 25 in each group of grounding switches 25 in the adapter 20 is equal to the number of row groups into which the electrode units 12 of the corresponding electrode sheet are divided in circuit connection, or equal to the number of grounding lines 18 on the flexible circuit board of the corresponding electrode sheet; the number of bidirectional switching switches 26 in each group of bidirectional switching switches 26 provided on the adapter 20 is equal to the number of column groups into which the electrode units 12 of the corresponding electrode sheet are divided in circuit connection, or equal to the number of dual-purpose signal lines 19 on the flexible circuit board of the corresponding electrode sheet.

[0144] The present invention also provides a method for detecting the temperature of the electrode sheet 10 used in the tumor electric field treatment system 100, referring to Figure 10 As shown, the method includes:

[0145] Step S10 : performing handshake communication with the handshake chip 17 of the electrode sheet 10 through the adapter 20 to determine the connection status of the corresponding electrode sheet 10 .

[0146] Step S20: When the electrode sheet 10 and the adapter 20 are connected normally, the switch states of each grounding switch 25 and each bidirectional switching switch 26 corresponding to the electrode sheet 10 are configured through the adapter 20, so that the temperature signals detected by each temperature sensor 14 in each row group are sampled in turn through the corresponding temperature sampling points.

[0147] The present invention also provides a method for identifying the type of an electrode sheet. The electrode sheet type identification is performed when all temperature sensors of the electrode sheet are normally connected. In addition to the above steps S10 and S20, the method further includes:

[0148] Step S30 : identifying the type of the corresponding electrode sheet 10 according to the sampled temperature signals detected by all the temperature sensors 14 of the corresponding electrode sheet 10 .

[0149] In step S30, the temperature signals detected by all the temperature sensors 14 of the corresponding electrode sheet 10 are sampled and obtained as temperature analog signals. Step S30 specifically includes the following steps:

[0150] Step S301: performing digital-to-analog conversion on all sampled temperature analog signals to obtain a number of AD sampling values;

[0151] Step S302: determining the number of electrode units 12 of the corresponding electrode sheet 10 according to a number of AD sampling values;

[0152] Step S303 : determining the type of the corresponding electrode sheet 10 according to the number of electrode units 12 .

[0153] The present invention also provides a method for determining an abnormal temperature of an electrode sheet. The abnormal temperature determination of the electrode sheet is performed during the process of applying an alternating current signal through each electrode unit of the electrode sheet to perform tumor electric field therapy. In addition to the above steps S10 and S20, the method further includes the following steps:

[0154] Step S40: determining whether a temperature abnormality occurs in the corresponding electrode sheet 10 based on the sampled temperature signals detected by all temperature sensors of the corresponding electrode sheet.

[0155] Step S40 specifically includes the following steps:

[0156] Step S401: comparing all sampled temperature signals with a preset temperature threshold;

[0157] Step S402: Determine whether there is temperature abnormality on the electrode sheet based on the comparison result.

[0158] The comparison results in step S402 include the temperature signal being less than a preset temperature threshold and the temperature signal being greater than or equal to the preset temperature threshold. The specific determination of temperature anomaly is as follows: if any of the sampled temperature signals is greater than or equal to the preset temperature threshold, the electrode sheet temperature is determined to be abnormal; if all the sampled temperature signals are less than the preset temperature threshold, the electrode sheet temperature is determined to be normal. The preset temperature threshold is 39°C to 44°C, preferably 41°C.

[0159] The present invention also includes a method for regulating an alternating electrical signal. In addition to steps S10 and S20, the method further includes regulating the alternating electrical signal applied to the corresponding electrode sheet based on the sampled temperature signals detected by all temperature sensors of the corresponding electrode sheet. The regulation is to adjust the voltage, current, or power of the alternating electrical signal.

[0160] refer to Figure 11 As shown, the present invention also provides an electric field control method applied to the tumor electric field treatment system 100, and the electric field control method includes the following steps:

[0161] In step 101 , the tumor treating field system 100 is connected.

[0162] Specifically, the four electrode sheets 10 are connected to the adapter 20 respectively, the adapter 20 is connected to the electric field generator 30, and the electric field generator 30 is connected to an adapted power source.

[0163] In step 102, it is detected whether the user issues a command to turn on the electric field. If no command to turn on the electric field is detected, step 102 is repeated; if a command to turn on the electric field is detected, step 103 is entered.

[0164] In step 103, the electric field generator 30 of the tumor electric field therapy system 100 sends a handshake signal to the electrode sheet 10 connected to the X1 port through the second connector 50, the adapter 20, and the first connector 40 connected to the X1 port. Then, the first controller 22 of the adapter 20 receives the feedback signal from the electrode sheet 10 of the X1 port through the corresponding communication transmission line 211 to determine whether the handshake is passed; if not, go to step 105; if passed, go to step 106.

[0165] This judgment step can occur in the adapter 20 or in the electric field generator 30. In this embodiment, the judgment step occurs in the adapter 20. Specifically, when the electrode sheet 10 at the X1 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feedback the handshake status to the first controller 22 of the adapter 20. The first controller 22 then determines that the handshake is successful. Conversely, when the electrode sheet 10 at the X1 port is connected abnormally, the first controller 22 of the adapter 20 cannot receive the feedback signal from its handshake chip 17, and the first controller 22 then determines that the handshake has failed.

[0166] In step 105 , the tumor therapeutic field system 100 issues an alarm due to handshake failure and then proceeds to step 101 .

[0167] In step 106, the electric field generator 30 sends a handshake signal to the electrode sheet 10 connected to the X2 port through the second connector 50, the adapter 20, and the first connector 40 connected to the X2 port. Then, the first controller 22 on the adapter 20 receives the feedback signal from the electrode sheet 10 of the X2 port through the corresponding communication transmission line 211, and determines whether the handshake is passed. If not, the process goes to step 105; if passed, the process goes to step 107.

[0168] This determination step can occur in the adapter 20 or in the electric field generator 30. In this embodiment, the determination step occurs in the adapter 20. Specifically, when the electrode sheet 10 at the X2 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feedback the handshake status to the first controller 22 of the adapter 20. The first controller 22 then determines that the handshake is successful. Conversely, when the electrode sheet 10 at the X2 port is connected abnormally, the first controller 22 of the adapter 20 cannot receive the feedback signal from its handshake chip 17, and the first controller 22 then determines that the handshake has failed.

[0169] In step 107, after the electric field generator 30 sends a handshake signal to the electrode sheet 10 connected to the Y1 port through the second connector 50, the adapter 20, and the first connector 40 connected to the Y1 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode sheet 10 of the Y1 port through the corresponding communication transmission line 211, and determines whether the handshake is passed. If not, go to step 105; if passed, go to step 108.

[0170] This judgment step can occur in the adapter 20 or in the electric field generator 30. In this embodiment, the judgment step occurs in the adapter 20. Specifically, when the electrode sheet 10 at the Y1 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feedback the handshake status to the first controller 22 of the adapter 20. The first controller 22 then determines that the handshake is successful. Conversely, when the electrode sheet 10 at the Y1 port is connected abnormally, the first controller 22 of the adapter 20 cannot receive the feedback signal from its handshake chip 17, and the first controller 22 then determines that the handshake has failed.

[0171] In step 108, after the electric field generator 30 sends a handshake signal to the electrode sheet 10 connected to the Y2 port through the second connector 50, the adapter 20, and the first connector 40 connected to the Y2 port, the first controller 22 on the adapter 20 receives the feedback signal from the electrode sheet 10 of the Y2 port through the corresponding communication transmission line 211, and determines whether the handshake is passed. If not, go to step 105; if passed, go to step 109.

[0172] This judgment step can occur in the adapter 20 or in the electric field generator 30. In this embodiment, the judgment step occurs in the adapter 20. Specifically, when the electrode sheet 10 at the Y1 port is connected normally, its handshake chip 17 can receive the handshake request signal from the electric field generator 30 and feedback the handshake status to the first controller 22 of the adapter 20. The first controller 22 determines that the handshake is successful. Conversely, when the electrode sheet 10 at the Y2 port is connected abnormally, the first controller 22 of the adapter 20 cannot receive the feedback signal from its handshake chip 17, and the first controller 22 determines that the handshake has failed.

[0173] In steps 103, 106, 107, and 108 above, after receiving the handshake signal from the tumor electric field therapy system 100, the adapter 20 needs to control the corresponding grounding switch 25 and bidirectional switch 26 through the first controller 22, so that only the grounding switch 25 electrically connected to the handshake chip 17 is closed, the remaining grounding switches 24 are all disconnected, and the sampling terminals 1 of the corresponding bidirectional switches 26 are all connected and the input terminals 2 are all disconnected, so that the handshake chip 17 is electrically connected to the ground pin GND of the adapter 20 through the first connector 40, so that the handshake chip 17 can operate normally. If the connections between the electric field generator 30 and the adapter 20, between the adapters 20 and the adapters 20, and between the adapter 20 and the electrode sheet 10 are all normal, then the handshake signal emitted by the electric field generator 30 will eventually reach the handshake chip 17 of the electrode sheet 10, and the handshake status of the handshake chip 17 can be fed back to the electric field generator 30. If there is at least one connection abnormality between the electric field generator 30 and the adapter 20, between the adapter 20 and the adapter 20, and between the adapter 20 and the electrode sheet 10, the handshake chip 17 cannot connect VCC and GND to form a loop, resulting in the adapter 20 and the electric field generator 30 receiving the handshake status as an empty signal, and the handshake fails.

[0174] In step 109, electric field generator 30 of tumor treating field system 100 sets electric field parameters and then proceeds to step 110. Electric field parameters include the frequency, voltage, current, or power amplitude of the alternating electric signal.

[0175] In step 110, the adapter 20 sends a temperature reading request to the first connector 40 at the Y1 port and the first connector 40 at the Y2 port to collect the temperature detection signals corresponding to the 40 temperature sensors 14 on the electrode sheet 10 at the Y1 port and the electrode sheet 10 at the Y2 port, and then enters step 111.

[0176] In step 111 , the tumor therapeutic field system 100 determines the types of the electrode sheet 10 at the Y1 port and the electrode sheet 10 at the Y2 port by collecting the obtained temperature signals and then proceeds to step 112 .

[0177] The types of the electrode sheet 10 at the Y1 port and the electrode sheet 10 at the Y2 port are determined by determining the number of temperature sensors 14 at the Y1 port and the Y2 port, respectively, based on the number of temperature detection signals collected from the electrode sheet 10 at the Y1 port and the temperature detection signals collected from the electrode sheet 10 at the Y2 port. This determination process can occur in the adapter 20 or in the electric field generator 30. In this embodiment, the electrode sheet 10 has 20 temperature sensors 14, and therefore has a total of 40 valid temperature signals.

[0178] In step 112, the tumor therapy field system 100 determines whether the temperature signal collected by the adapter 20 is abnormal. If so, the process proceeds to step 114. If the temperature signal is normal, the process proceeds to step 113.

[0179] In step 113 , the electric field generator 30 applies an alternating current signal to the pair of electrode sheets 10 connected to the Y1 and Y2 ports, and stops applying the alternating current signal to the pair of electrode sheets 10 connected to the X1 and X2 ports and proceeds to step 115 .

[0180] In step 114 , the tumor electric field therapy system 100 issues an alarm due to an abnormal temperature signal of the electrode sheet 10 connected to the Y1 port or the electrode sheet 10 connected to the Y2 port, and then immediately enters step 120 .

[0181] In step 115 , the adapter 20 sends a temperature reading request to the first connector 40 of the X1 port and the first connector 40 of the X2 port to collect the temperature signals corresponding to all temperature sensors 14 on the electrode sheet 10 at the X1 port and the electrode sheet 10 at the X2 port, and enters step 116 .

[0182] In step 116 , the tumor therapy field system 100 determines the types of the electrode sheet 10 at the X1 port and the electrode sheet 10 at the X2 port according to the temperature signal and then proceeds to step 117 .

[0183] The type of the electrode sheet 10 at the X1 port and the electrode sheet 10 at the X2 port is determined by determining the number of temperature sensors 14 connected to the electrode sheet 10 at the X1 port and the electrode sheet 10 connected to the X2 port. This determination process can occur in the adapter 20 or the electric field generator 30. In this embodiment, the electrode sheet 10 has 20 temperature sensors 14, so there are a total of 40 valid temperature signals.

[0184] In step 117 , the tumor therapy field system 100 determines whether the temperature signal collected by the adapter 20 is abnormal. If so, the process proceeds to step 114 . If all 40 valid temperature signals are normal, the process proceeds to step 118 .

[0185] In step 118, electric field generator 30 applies an alternating electrical signal to the pair of electrode sheets 10 connected to ports X1 and X2, and simultaneously stops applying the alternating electrical signal to the pair of electrode sheets 10 connected to ports Y1 and Y2, and proceeds to step 119. The total time for steps 113, 115, 116, 117, and 118 is fixed at 1 second.

[0186] In step 119, the tumor electric field therapy system 100 executes subsequent steps based on whether it detects that a shutdown command from the user has been received. If it is detected that a shutdown command has been received, it proceeds to step 120; if it is not detected that a shutdown command has been received, it proceeds to step 121.

[0187] In step 120, tumor therapeutic field system 100 turns off the electric field and then proceeds to step 101. At this point, the electric field therapy ends and the system waits for the next electric field turn-on command.

[0188] In step 121, the tumor therapeutic field system 100 determines whether electric field parameters need to be adjusted based on the current electric field amplitude and the collected temperature signal. If so, the system proceeds to step 109. If not, the system proceeds to steps 110 through 119, looping. The total duration of steps 118, 119, 121, 110, 111, 112, and 113 is fixed, and in this embodiment, is 1 second. This allows the tumor therapeutic field system 100 to continuously output alternating electrical signals, alternating between applying an alternating electrical signal in a first direction between a pair of electrodes 10 connected to ports X1 and X2 and applying an alternating electrical signal in a second direction between another pair of electrodes 10 connected to ports Y1 and Y2, with a 2-second period. At the same time, the tumor electric field therapy system 100 can reduce the time interval between turning off the alternating electric signal applied to a pair of electrode sheets 10 connected to the X1 and X2 ports and turning on the alternating electric signal applied to another pair of electrode sheets 10 connected to the Y1 and Y2 ports to 0s; and reduce the time interval between turning off the alternating electric signal applied to another pair of electrode sheets 10 connected to the Y1 and Y2 ports and turning on the alternating electric signal applied to a pair of electrode sheets 10 connected to the X1 and X2 ports to 0s, thereby extending the electric field therapy time while ensuring the accuracy of temperature collection.

[0189] The present application also provides some temperature detection methods and AC signal application control methods, which are described below using the electrode sheet 10 as an example.

[0190] The present application embodiment provides an electrode sheet temperature detection method, which is applied to the above-mentioned electrode sheet 10 or tumor electric field treatment system 100. Figure 12 As shown, it includes the following steps:

[0191] Step 210: After confirming that the electrode sheet is properly connected through the handshake chip, control the bidirectional switches 26 electrically connected to the electrode units 12 of the electrode sheet 10 to disconnect the AC signal applied to the dielectric element 15 of each electrode unit 12 of the electrode sheet 10 and connect the DC signal applied to the signal terminal 14-2 of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10;

[0192] Step 220 : sequentially turn on the grounding switches 25 electrically connected to the grounding terminals 14 - 1 of the temperature sensors 14 of the electrode units 12 of each row group of the electrode sheet 10 to obtain temperature detection signals from the temperature sensors 14 of each electrode unit 12 of the electrode sheet 10 .

[0193] Step 210 is specifically as follows: controlling the bidirectional switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 to switch from the end thereof electrically connected to the AC signal to the end thereof electrically connected to the DC signal, that is, controlling the bidirectional switch 26 electrically connected to the electrode sheet 10 to switch from its input end 2 to its sampling end 1; or

[0194] The bidirectional switching switch 26 electrically connected to each electrode unit 12 of the electrode sheet 10 is controlled to switch the dielectric element 15 of each electrode unit 12 of the electrode sheet 10 from the on state to the off state, and at the same time, the signal end 14-2 of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10 is switched from the off state to the on state.

[0195] The electrode sheet temperature detection method of the present application can quickly and accurately obtain the temperature detection signals of all electrode units of the electrode sheet; and based on the obtained temperature detection signals of all temperature sensors of the electrode sheet, it can be judged whether the temperature sensors of the electrode sheet are faulty, whether there is an abnormality, whether the electrode sheet is qualified, and whether it needs to be replaced; it can also be judged whether each electrode unit of the electrode sheet is overheated based on the obtained temperature detection signals of all temperature sensors of the electrode sheet when each temperature sensor of the electrode sheet is normal, and then control the AC signal applied to the electrode sheet or applied to each electrode unit of the electrode sheet; it can also be used to identify the type of electrode sheet when there is no abnormality in the temperature detection signals of each temperature sensor of the electrode sheet.

[0196] Ginseng Figure 13 As shown, the embodiment of the present application further provides a method for controlling application of an AC signal for tumor electric field therapy, which includes the above steps 210 and 220, and after step 220, further includes:

[0197] Step 260 : When it is determined that the electrode sheet 10 does not need to be replaced, the AC signal applied to each electrode unit 12 of the electrode sheet 10 is controlled or adjusted according to the temperature detection signal of the temperature sensor 14 of each electrode unit 12 of the electrode sheet 10 .

[0198] Controlling or adjusting the AC signal applied to each electrode unit 12 of the electrode sheet 10 in step 260 also includes:

[0199] Step 261: When the temperature detection signals of the electrode units 12 of the electrode sheet 10 obtained do not exceed the preset temperature threshold, continue to apply the AC signal to the electrode units 12 of the electrode sheet 10; or

[0200] Step 262 : When a temperature detection signal among the acquired temperature detection signals of all the electrode units 12 of the electrode sheet 10 exceeds a preset temperature threshold, stop applying the AC signal to the electrode units 12 of the electrode sheet 10 .

[0201] The stopping of applying the AC signal to the electrode unit 12 of the electrode sheet 10 described in step 262 includes stopping applying the AC signal to all electrode units 12 of the electrode sheet 10, stopping applying the AC signal to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold, and stopping applying the AC signal to all electrode units 12 in the column where the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold is located.

[0202] When the application of the AC signal to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal exceeds the preset temperature threshold is stopped, the AC signal continues to be applied to the electrode unit 12 in the electrode sheet 10 whose temperature detection signal does not exceed the preset temperature threshold.

[0203] When the application of the AC signal to all electrode units 12 in the column where the electrode unit 12 whose temperature detection signal exceeds the preset temperature threshold in the electrode sheet 10 is located is stopped, the AC signal continues to be applied to all electrode units 12 in the electrode sheet 10 where the temperature detection signal does not exceed the preset temperature threshold and is in a different column from the electrode unit 12 whose temperature detection signal exceeds the preset temperature threshold.

[0204] The process of continuing to apply the AC signal to the electrode sheet 10 in step 261 is specifically as follows:

[0205] Step 263: When the temperature detection signal is much lower than the preset temperature threshold, continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner of increasing the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 or continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner of keeping the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 unchanged; or

[0206] Step 264: When the temperature detection signal approaches a preset temperature threshold, continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that keeps the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10 unchanged, or continue to apply the AC signal to each electrode unit 12 of the electrode sheet 10 in a manner that reduces the voltage or current amplitude of the AC signal applied to each electrode unit 12 of the electrode sheet 10.

[0207] Ginseng Figure 14 As shown, the present application also provides a signal control method for tumor electric field therapy, which is used for the above-mentioned electrode sheet 10, and the method includes:

[0208] Step 310: Combining and controlling a set of grounding switches 25 and a set of bidirectional switches 26 electrically connected to the corresponding electrode sheets 10 to apply an AC signal to each electrode unit 12 of the electrode sheet 10 and executing step 320;

[0209] Step 320: Combining and controlling a set of grounding switches 25 and a set of bidirectional switches 26 electrically connected to the electrode sheet 10 to collect temperature detection signals of each electrode unit of the electrode sheet 10 in a row and executing step 330;

[0210] Step 330: Determine a combined control mode of a group of grounding switches 25 and a group of bidirectional switches 26 electrically connected to the electrode sheet 10 according to the collected temperature detection signal and execute step 340;

[0211] Step 340 : Control the working state of each electrode unit 12 of the electrode sheet 10 according to the determined combined control mode of the grounding switch 25 and the bidirectional switch 26 .

[0212] The operating state of each electrode unit 12 of the electrode sheet 10 described in step 340 includes one of: stopping applying the AC signal and continuing to collect the temperature detection signal; and stopping collecting the temperature detection signal and continuing to apply the AC signal. Continuing to apply the AC signal includes continuing to apply the AC signal in a manner of increasing the voltage or current amplitude of the currently applied AC signal, continuing to apply the AC signal in a manner of maintaining the voltage or current amplitude of the currently applied AC signal, or continuing to apply the AC signal in a manner of reducing the voltage or current amplitude of the currently applied AC signal.

[0213] The operating state of each electrode unit 12 of the electrode sheet 10 is determined by the temperature detection signal collected by the electrode unit 12. The electrode units 12 of the electrode sheet 10 are divided into different areas. The combination of the grounding switch 25 and the bidirectional switch 26 controls each electrode unit 12 in each area to cyclically switch between applying an AC signal and collecting a temperature detection signal.

[0214] This embodiment of the application provides another method for detecting the temperature of an electrode sheet in a tumor electric field therapy system. Figure 15 As shown, taking the electrode sheet 10 as an example, the temperature detection method includes:

[0215] Step 510: disconnect the AC signal input to the electrode sheet 10, perform combination control on the multiple grounding switches 25 and the multiple bidirectional switches 26, and obtain the temperature detection signal of the temperature sensor 14 of the electrode sheet 10 corresponding to each combination in all combinations;

[0216] Step 520: sampling and converting the temperature detection signal detected by each temperature sensor 14 in the electrode sheet 10 to obtain a digital temperature signal;

[0217] Step 530: Transmit the digital temperature signal to the electric field generator 30 of the tumor electric field therapy system 100, so that the electric field generator 30 determines the temperature at the corresponding electrode unit 12 according to the digital temperature signal.

[0218] In step 510, “combined control of the plurality of grounding switches 25 and the plurality of bidirectional switches 26” specifically includes:

[0219] Step 511: placing all bidirectional switches 26 at the sampling terminal 1 to conduct electrical connections between the signal terminals 14 - 2 of the temperature sensors 14 of all electrode units 12 and the corresponding analog-to-digital converters 23 ;

[0220] Step 512: Sequentially and individually closing one of the plurality of grounding switches 25 in a time-sharing manner to collect the temperature detection signals detected by the temperature sensors 14 of the electrode units 12 in the corresponding row group row by row.

[0221] In step 512 , sequentially and time-sharingly closing one of the plurality of grounding switches 25 can connect the detection channels electrically connected between the analog-to-digital converter 23 and each temperature sensor 14 in the row group corresponding to the closed grounding switch 25 .

[0222] In this way, the temperature detection signals of the corresponding temperature sensors 14 in each row group can be obtained in turn, and then after processing by the adapter 20 or the electric field generator 30, the corresponding temperatures of all electrode units 12 on the electrode sheet 10 can be obtained; thereby making the temperature detection of the patient's body surface more comprehensive and accurate.

[0223] For the tumor electric field therapy system 100 of the embodiment of the present application, the temperature of a single electrode unit 12 can also be detected as needed. The specific process of the method for performing temperature detection on a certain electrode unit 12 of the electrode sheet 10 is as follows: disconnect the input of the AC signal, place the bidirectional switch 26 corresponding to the column group where the electrode unit 12 that needs to be individually measured is located at the sampling end 1, and place the remaining bidirectional switches 26 at the input end 2; at the same time, turn on and ground the ground switch 25 corresponding to the row group where the electrode unit 12 that needs to be individually measured is located, and disconnect all the remaining ground switches 25. In this way, the temperature detection signal of the temperature sensor 14 in the electrode unit 12 that needs to be individually measured can be sampled to obtain the temperature of the electrode unit 12. For example, if the electrode unit 12 that requires independent temperature measurement is electrode unit 12-1, the first bidirectional switch 26-1 corresponding to electrode unit 12-1 is placed at sampling terminal 1, and the remaining bidirectional switches (second bidirectional switch 26-2, second bidirectional switch 26-3, third bidirectional switch 26-3, and fourth bidirectional switch 26-4) are all placed at input terminal 2. At the same time, the first grounding switch 25-1 corresponding to electrode unit 12-1 is closed and grounded, and the remaining grounding switches (second grounding switch 25-2, third grounding switch 25-3, and fourth grounding switch 25-4) are all opened. In this way, the temperature of electrode unit 12-1 can be detected.

[0224] The present application also provides another method for applying an alternating current signal for tumor electric field therapy, which is applied to the above-mentioned tumor electric field therapy system. Figure 1 The tumor electric field treatment system 100 in FIG. Figure 16 As shown, the AC signal applying method includes:

[0225] Step 610: Determine the area of ​​the electrode unit 12 in the electrode sheet 10 where the alternating current signal needs to be applied;

[0226] Step 611: Combining and controlling the plurality of grounding switches 25 and the plurality of bidirectional switches 26 electrically connected to the electrode sheet 10 to apply an alternating current signal.

[0227] In step 611, “combining and controlling the plurality of grounding switches 25 and the plurality of bidirectional switches 26 electrically connected to the electrode sheet 10” is specifically as follows:

[0228] Step 612: Disconnect all grounding switches 25 electrically connected to the electrode sheet 10;

[0229] Step 613: determining the column group where the electrode units 12 to which the AC signal needs to be applied are located according to the area where the electrode units 12 to which the AC signal needs to be applied are located;

[0230] Step 614: Determine the bidirectional switch 26 electrically connected to the electrode units 12 in the column group according to the column group where the electrode units 12 to which the AC signal needs to be applied are located;

[0231] In step 610, every four adjacent electrode units 12 in the electrode sheet 10 are divided into a region. The four electrode units 12 in each region correspond to a column group, which is connected to a dual-purpose signal line 19 corresponding to the same bidirectional switch 26. In other embodiments, the electrode units 12 can be divided in other ways, which will not be repeated here.

[0232] Step 615: Control the bidirectional switching switch 26 electrically connected to the electrode unit 12 to which an AC signal needs to be applied so that the electrode unit 12 to which an AC signal needs to be applied is electrically connected to the AC signal line 28 to apply the AC signal; at the same time, control the remaining bidirectional switching switches 26 so that the electrical connection between each electrode unit 12 in the area where no AC signal needs to be applied and the AC signal line 28 is disconnected to stop applying the AC signal.

[0233] In step 615, "electrically connecting the electrode units to which an AC signal needs to be applied to the AC signal line 28 to apply the AC signal and disconnecting the electrical connection between the electrode units 12 in the area where the AC signal does not need to be applied and the AC signal line 28 to stop applying the AC signal" is achieved by placing the bidirectional switching switch 26 electrically connected to the electrode units 12 in the column group corresponding to the area to which the AC signal is to be applied in the electrode sheet 10 at its input end 2, and placing all the bidirectional switching switches 26 electrically connected to the electrode units 12 in the remaining column groups at the sampling end 1.

[0234] When the above methods are applied to the electrode sheets 10D, 10E, 10F and 10H in other embodiments, since there are grounding switches 25 in an idle disconnected state and / or bidirectional switching switches 26 in an idle disconnected state on the adapter 20 that are not electrically connected to the corresponding electrode sheets 10D, 10E, 10F and 10H, the corresponding grounding switches 25 in an idle disconnected state and / or bidirectional switching switches 26 in an idle disconnected state do not need to be controlled accordingly.

[0235] While various operations are depicted in the drawings as following a particular order, this should not be understood as requiring that these operations be performed in the particular order shown or in sequential order, nor should it be understood that all illustrated operations must be performed to achieve desirable results.

[0236] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some or all of the technical features therein. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present application, and they should all be included in the scope of the claims and specification of the present application. In particular, as long as there is no structural conflict, the various technical features mentioned in the various embodiments can be combined in any way. The present application is not limited to the specific embodiments disclosed herein, but includes all technical solutions that fall within the scope of the claims.

Claims

1. An electrode sheet for a tumor electric field treatment system, characterized in that: include: A plurality of electrode units, each of the electrode units being divided into a plurality of row groups and a plurality of column groups in terms of circuit connection, and being arranged in at least two row groups or three column groups in terms of circuit connection, the electrode units comprising a dielectric element for transmitting an AC signal and a temperature sensor for detecting the temperature thereof and having a signal terminal and a ground terminal; a handshake chip, the handshake chip being configured to determine the connection status of the electrode sheet through handshake communication; as well as The flexible circuit board is configured to accommodate the handshake chip and the plurality of electrode units at intervals thereon, and has multiple conductive traces embedded therein, the multiple conductive traces comprising: Multiple grounding lines, corresponding one-to-one to the plurality of row groups, wherein the grounding ends of the temperature sensors in the same row group are short-circuited via the same grounding line, and the grounding ends of the temperature sensors in different row groups are connected in parallel via different grounding lines; Multiple dual-purpose signal lines correspond one-to-one to the plurality of column groups, wherein the signal ends of the temperature sensors in the same column group are short-circuited to the same dual-purpose signal line, and the signal ends of the temperature sensors in different column groups are connected in parallel via different dual-purpose signal lines; each of the dual-purpose signal lines is configured to: in a first mode, transmit an alternating current signal to the dielectric element of each electrode unit in the corresponding column group; and in a second mode, transmit a direct current signal or a temperature signal detected by the temperature sensor of each electrode unit in the corresponding column group to the signal end of the temperature sensor; a ground trace configured to connect the handshake chip to ground; and a communication line electrically connected to a corresponding portion of the handshake chip; Wherein, in the second mode, only one of the multiple grounding lines is connected at the same time, and the other grounding lines are disconnected.

2. The electrode sheet according to claim 1, characterized in that The number of the dual-purpose signal lines is related to the number of column groups into which the electrode unit is divided, and the number of the ground lines is related to the number of row groups into which the electrode unit is divided.

3. The electrode sheet according to claim 2, characterized in that: The number of the dual-purpose signal lines is equal to the number of column groups into which the electrode units are divided.

4. The electrode sheet according to claim 2, characterized in that The number of the grounding lines is equal to the number of the row groups into which the electrode units are divided.

5. The electrode sheet according to claim 1, characterized in that The dielectric element of each electrode unit is short-circuited with the signal end of the temperature sensor.

6. The electrode sheet according to claim 1, characterized in that Each of the electrode units further includes a diode connected in series with a temperature sensor, and the temperature sensor is grounded via the diode connected in series with the temperature sensor.

7. The electrode sheet according to claim 1, characterized in that The dielectric elements of the plurality of electrode units in the same column group are connected in parallel to the same dual-purpose signal line of the flexible circuit board; the dielectric elements of the plurality of electrode units in different column groups are connected in parallel through different dual-purpose signal lines of the flexible circuit board; the dielectric elements of the plurality of electrode units in the same row group are connected in parallel through different dual-purpose signal lines of the flexible circuit board; and the dielectric elements of the plurality of electrode units in different row groups and different column groups are connected in parallel to different dual-purpose signal lines of the flexible circuit board.

8. The electrode sheet according to claim 1, characterized in that The dielectric elements of the plurality of electrode units in the same column group and the signal ends of the respective temperature sensors are connected in parallel via the same dual-purpose signal line of the flexible circuit board, while the dielectric elements of the plurality of electrode units in different column groups and the signal ends of the respective temperature sensors are connected in parallel via different dual-purpose signal lines of the flexible circuit board.

9. The electrode sheet according to claim 1, characterized in that: The ground ends of the temperature sensors of the multiple electrode units located in the same column group are respectively connected in parallel through the ground lines of different paths of the flexible circuit board; the signal ends of the temperature sensors of the multiple electrode units located in the same row group are respectively connected in parallel through the dual-purpose signal lines of different paths of the flexible circuit board.

10. The electrode sheet according to claim 1, characterized in that The dielectric elements of the plurality of electrode units in the same row group are respectively connected in parallel via different dual-purpose signal lines of the flexible circuit board, and the dielectric elements of the plurality of electrode units in the same column group are all short-circuited via the same dual-purpose signal line of the flexible circuit board.

11. The electrode sheet according to claim 1, characterized in that The temperature signals detected by the temperature sensors in each row group are sampled simultaneously after the handshake chip completes the handshake communication.

12. The electrode sheet according to claim 1, characterized in that The sampled temperature signal detected by the temperature sensor is used to characterize the type of the electrode sheet.

13. The electrode sheet according to claim 1, characterized in that The handshake chip has a ground pin electrically connected to the ground trace and a communication pin electrically connected to the communication line. The ground pin is connected to one ground line among the multiple ground lines through the ground trace.

14. The electrode sheet according to claim 1, characterized in that The handshake chip stores energy when the communication line transmits a high level and releases energy when the communication line transmits a low level.

15. The electrode sheet according to claim 1, characterized in that The sampled temperature signal detected by the temperature sensor is also used to indicate whether the electrode sheet has a temperature abnormality.

16. A tumor electric field treatment system, characterized in that: The method comprises at least one pair of electrode sheets according to any one of claims 1 to 15.

17. The tumor electric field treatment system according to claim 16, wherein: Also includes: an electric field generator configured to apply an alternating current signal to the plurality of electrode units of the electrode sheet via the dual-purpose signal line of the electrode sheet; and The adapter is connected between the electrode sheet and the electric field generator, and is configured to transmit the alternating current signal generated by the electric field generator to the multiplexed signal line of the electrode sheet, and is also configured to receive the temperature signal detected by the multiplexed signal line of the electrode sheet, and is also configured to perform handshake communication with the handshake chip, and after completing the handshake communication, time-sharingly sample the temperature signal detected by each electrode unit in each row group.

18. The tumor electric field treatment system according to claim 17, characterized in that: The adapter comprises: An AC signal line is configured to apply an alternating current signal to each of the electrode units in the corresponding column group through the plurality of dual-purpose signal lines.

19. The tumor electric field treatment system according to claim 18, wherein: The adapter further includes a switch unit, which includes: Multiple groups of grounding switches, each group of grounding switches is electrically connected to a corresponding electrode sheet and includes multiple grounding switches, and the multiple grounding switches in each group of grounding switches are respectively electrically connected to the multiple grounding lines of the corresponding electrode sheet in a one-to-one correspondence and are configured to control the conduction or disconnection of the multiple grounding lines.

20. The tumor electric field treatment system according to claim 19, wherein: The adapter also includes: A plurality of analog-to-digital converters are electrically connected to the multiple dual-purpose signal lines of the corresponding electrode sheets, and are configured to receive the temperature signals detected by the multiple dual-purpose signal lines of the corresponding electrode sheets and convert the temperature signals from analog signals to digital signals. Wherein, each group of the analog-to-digital converters includes a plurality of detection channels, and each detection channel is used to connect to a corresponding dual-purpose signal line among the plurality of dual-purpose signal lines.

21. The tumor electric field treatment system according to claim 20, wherein: The switch unit further includes: a plurality of groups of bidirectional switches, each corresponding to the plurality of electrode sheets, each group of bidirectional switches including a plurality of bidirectional switches, wherein the plurality of bidirectional switches in each group of bidirectional switches are electrically connected one by one to the plurality of dual-purpose signal lines of the corresponding electrode sheets; Each of the bidirectional switches further comprises a sampling terminal electrically connected to a corresponding detection channel in the corresponding analog-to-digital converter and an input terminal electrically connected to the AC signal line.

22. The tumor electric field treatment system according to claim 21, wherein: The adapter also includes: The first controller is connected to the plurality of groups of grounding switches and the plurality of groups of bidirectional switches, and is configured to: for sequentially and cyclically controlling the on / off states of the corresponding groups of grounding switches, thereby sequentially and individually conducting each of the multiple grounding wires of the corresponding electrode sheet; and for controlling the switching state of the corresponding group of bidirectional switches, so that each bidirectional switch is placed at a sampling end to output a detected temperature signal or at an input end to transmit an AC signal; and It is used to configure the switch state of the grounding switches in the corresponding group and the switching state of the bidirectional switches in the corresponding group when receiving the handshake signal sent by the electric field generator so that the handshake chip is powered on and operates, and to send the handshake signal to the handshake chip and to judge whether the handshake communication with the handshake chip is completed according to the feedback signal of the handshake chip. After the handshake communication is completed, by configuring the switch state of each grounding switch in the corresponding group and the switching state of each bidirectional switch in the corresponding group, the analog-to-digital converter in the corresponding group simultaneously samples the temperature signals detected by each temperature sensor in the corresponding row group, and then performs analog-to-digital conversion on the temperature signals obtained to obtain multiple digital signals.

23. The tumor electric field treatment system according to claim 22, wherein: The adapter also includes: The first communication unit is configured to obtain a plurality of digital signals output by the analog-to-digital converters and send the digital signals to the electric field generator.

24. The tumor electric field treatment system according to claim 23, wherein: The electric field generator is further configured to control or adjust an alternating current signal applied to a corresponding electrode unit among the plurality of electrode units of the corresponding electrode sheet according to the received digital signal.

25. The tumor electric field treatment system according to claim 23, wherein: The first communication unit is controlled by the first controller and serially transmits the digital signal converted by the analog-to-digital converter.

26. The tumor electric field treatment system according to claim 22, wherein: The first controller is further configured to identify the type of the corresponding electrode sheet according to the plurality of digital signals.

27. The tumor electric field treatment system according to claim 22, wherein: The first controller is further configured to determine whether a temperature abnormality occurs in the corresponding electrode sheet according to a plurality of the digital signals during the process in which the electric field generator transmits the alternating current signal to the corresponding electrode sheet.

28. The tumor electric field treatment system according to claim 22, wherein: The first controller is further configured to send the plurality of digital signals to the electric field generator so that the electric field generator can identify the type of the corresponding electrode sheet according to the plurality of digital signals.

29. The tumor electric field treatment system according to claim 22, wherein: The electric field generator is further configured to determine whether a temperature abnormality occurs in the corresponding electrode sheet according to a plurality of the digital signals during the process of transmitting the alternating current signal to the corresponding electrode sheet.

30. A temperature detection method, characterized in that: Applied to the electrode sheet as described in any one of claims 1-15 or to the tumor electric field therapy system as described in any one of claims 16-29, the method comprises the following steps: determining the connection status of the corresponding electrode sheet by performing handshake communication with the handshake chip; and sampling the temperature signals detected by each electrode unit in each row group row by row in a time-sharing manner by configuring the on and off states of the multiple ground lines and the multiplexed signal lines of the electrode sheet when each electrode sheet is normally connected.

31. The temperature detection method according to claim 30, characterized in that: The multiple dual-purpose signal lines of the electrode sheet are all connected to their respective sampling ends, and each of the multiple grounding lines of the electrode sheet is connected in sequence and in time-sharing order. The temperature signals detected by each electrode unit of the electrode sheet are collected row by row through the multiple dual-purpose signal lines.

32. A tumor electric field treatment system, characterized in that: The invention comprises an electrode sheet according to any one of claims 1 to 15 and an electric field generator electrically connected to the electrode sheet, wherein the electric field generator is configured to: in a state where the electrode sheet is confirmed to be normally connected through a handshake chip, control the conduction and disconnection of multiple dual-purpose signal lines and multiple ground lines in combination, and realize cyclic switching between applying an alternating current signal and applying a direct current signal to each electrode unit of the electrode sheet for collecting or transmitting a temperature signal for detection through the multiple dual-purpose signal lines.

33. The tumor electric field treatment system according to claim 32, wherein: The electric field generator transmits an AC signal to each electrode unit through the multiple dual-purpose signal lines electrically connected to the electrode sheet by disconnecting the multiple ground lines electrically connected to the electrode units in each row group of the electrode sheet and simultaneously connecting the multiple dual-purpose signal lines electrically connected to the electrode units in each column group of the electrode sheet to their respective input ends.

34. The tumor electric field treatment system according to claim 32, wherein: The electric field generator transmits the temperature signals detected by all the electrode units in each row group of the electrode sheet in a time-sharing manner row by row through the multiple dual-purpose signal lines electrically connected to the electrode units in each column group of the electrode sheet, by conducting the multiple dual-purpose signal lines electrically connected to the electrode units in each column group of the electrode sheet to their respective collection ends and sequentially conducting one ground line among the multiple ground lines electrically connected to the electrode units in each row group of the electrode sheet in a time-sharing manner.

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