Bionic sebum film composition as well as preparation method and application thereof

Abstract

The invention discloses a bionic sebum film composition as well as a preparation method and application thereof, and relates to the technical field of cosmetics. According to the bionic sebum film composition provided by the invention, butyrospermum parkii butter, cholesterol and bis (lauramide glutamine) sodium lysine are mixed according to a specific proportion, so that a composition close to a cuticle intercellular lipid component can be obtained, and the composition is applied to cosmetics to obtain soothing and refreshing essence lotion; the moisturizing and soothing effects and the repairing effects are greatly improved, the water content of the cuticle of the skin of the human body can be increased by 50.97% or above after the facial mask is used for 28 days, the percutaneous loss moisture value is reduced by 10.3% or above, meanwhile, the heme content of the facial skin of the human body is reduced by 12.37% or above, and the facial red area can be at least reduced by 10.26%.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a bionic sebum film composition, a preparation method and application thereof. Background Art

[0002] The skin is the outermost protective organ of the human body and the first natural barrier of the human body to the outside world. It plays an important role in defending against external environmental invasion. In the stratum corneum of healthy skin, keratinocytes and intercellular lipids are arranged together in a form similar to a brick wall structure, in which keratinocytes are bricks and intercellular lipids are cement that fills the gaps between bricks. Intercellular lipids can be connected to each other through tight junction proteins, forming a tight lipid network between the "bricks". The orderly and tight combination of mature keratinocytes and intercellular lipids ensures the integrity of the skin barrier, which can not only seal and lock in moisture, but also resist the invasion of external substances such as chemicals and microorganisms.

[0003] The intercellular lipids in the stratum corneum are mainly composed of ceramides, cholesterol, and fatty acids, which account for approximately 50%, 25%, and 15%, respectively. When the stratum corneum of the skin is damaged, it often shows the characteristics of an imbalance in the proportion of intercellular lipid components, which can aggravate the invasion of irritants and cause skin sensitivity problems, or accelerate the loss of water in the body and cause skin dryness problems. By applying a bionic sebum composition or physiological lipids with similar ingredients and proportions, the problem of skin barrier damage can be repaired to a certain extent. Combining lipid compositions with other active ingredients and applying them to the field of skin care products and cosmetics can achieve convenient and daily repair. However, there is currently no essence lotion on the market that can effectively use bionic sebum compositions to moisturize and repair human skin. Summary of the invention

[0004] In order to solve the problems existing in the prior art, the present invention provides a bionic sebum film composition, which is obtained by mixing avocado tree fruit fat, cholesterol and sodium di(lauroyl glutamine) lysine in specific proportions to obtain a composition close to the intercellular lipid composition of the stratum corneum. Applying the composition in cosmetics can greatly improve the moisturizing, soothing and repairing effects of the cosmetics.

[0005] Another object of the present invention is to provide a method for preparing a bionic sebum film composition.

[0006] Another object of the present invention is to provide a soothing and revitalizing essence lotion.

[0007] The above-mentioned purpose of the present invention is achieved through the following technical solutions:

[0008] A bionic sebum film composition, comprising the following components calculated by mass:

[0009] 0.1-10 parts of avocado butter, 0.01-2 parts of cholesterol, and 0.0029-0.29 parts of sodium di(laurylamide glutamine) lysine.

[0010] In the bionic sebum film composition provided by the present invention, cholesterol is a substance originally existing in the stratum corneum of the skin, and together with ceramide and fatty acids, it constitutes the intercellular lipids in the stratum corneum, providing a barrier for the stratum corneum to prevent water loss and protecting the skin from the invasion of the external environment; avocado tree (BUTYROSPERMUM PARKII) fruit fat contains rich unsaturated fatty acids; sodium di(laurylamide glutamine) lysine has a structure similar to ceramide, but compared with ceramide, sodium di(laurylamide glutamine) lysine has better permeability and can more effectively enter the gaps between the keratinocytes of the stratum corneum, so that the bionic sebum film composition of the present invention can enter between the deeper keratinocytes after being applied to the surface of human skin, and then avocado tree (BUTYROSPERMUM PARKII) fruit fat, cholesterol and sodium di(laurylamide glutamine) lysine work synergistically, and the three can quickly build the structure of intercellular lipids, achieve the effect of deeply repairing the skin barrier, and can be used to prepare moisturizing and repairing skin care products.

[0011] Preferably, the biomimetic sebum film composition comprises the following components calculated by mass:

[0012] 1-5 parts of avocado butter, 0.1-1 parts of cholesterol, 0.0145-0.145 parts of sodium di(laurylamide glutamine) lysine.

[0013] More preferably, the biomimetic sebum film composition comprises the following components calculated by mass:

[0014] 3.5 parts of avocado butter, 0.2 parts of cholesterol, 0.029 parts of sodium di(laurylamide glutamine) lysine.

[0015] The present invention also protects a method for preparing the above-mentioned bionic sebum film composition, comprising the following steps:

[0016] A bionic sebum membrane composition can be obtained by uniformly mixing avocado tree fat, cholesterol and sodium di(laurylamide glutamine) lysine in a certain proportion at T°C, wherein T≥80°C.

[0017] The present invention also protects a soothing and revitalizing essence lotion, comprising the following components calculated by mass:

[0018] The bionic sebum film composition comprises 0.11 to 13 parts, a light protection component 0.201 to 13.3 parts, a soothing component 0.11 to 12 parts, a moisturizing component 0.0501 to 20 parts, a skin conditioner 0.021 to 3.3 parts, a chelating agent 0.01 to 0.1 parts, a thickener 0.01 to 0.1 parts, an emulsifier 0.1 to 3 parts, an emollient 0.5 to 41 parts, an antioxidant 0.11 to 3 parts and a solvent 65 to 80 parts.

[0019] Preferably, the photoprotective component in the soothing and revitalizing essence includes at least one of glucosylrutin, tara gum and biosaccharide gum-4.

[0020] Caesalpinia spirosa gum and biosaccharide gum-4 work synergistically to form a protective film on the skin surface, preventing external pollutants from damaging the skin, while also working in synergy with glucosylrutin to provide light protection.

[0021] More preferably, the light protection component includes the following components calculated by mass:

[0022] 0.001-0.3 parts of glucosylrutin, 0.01-0.5 parts of taro gum, and 0.1-3 parts of biosaccharide gum-4.

[0023] More preferably, the light protection component includes the following components calculated by mass:

[0024] 0.01-0.25 parts of glucosylrutin, 0.1-0.5 parts of taro gum, and 0.2-2 parts of biosaccharide gum-4.

[0025] More preferably, the light protection component includes the following components calculated by mass:

[0026] 0.03 parts of glucosylrutin, 0.3 parts of taro gum, and 1 part of biosaccharide gum-4.

[0027] Preferably, the soothing component in the soothing and revitalizing essence lotion includes at least one of artemisia annua extract and schizophyllan.

[0028] Artemisia annua extract and schizophyllan work synergistically to provide soothing effects.

[0029] More preferably, the soothing component includes the following components calculated by mass:

[0030] 0.01-2 parts of Artemisia annua extract and 0.1-10 parts of schizophyllanthus.

[0031] More preferably, the soothing component includes the following components calculated by mass:

[0032] 0.05-1 parts of Artemisia annua extract and 0.5-5 parts of schizophyllanthus.

[0033] More preferably, the soothing component includes the following components calculated by mass:

[0034] 0.8 parts of Artemisia annua extract and 3 parts of schizophyllanthus.

[0035] Preferably, the moisturizing component in the soothing and rejuvenating essence includes at least one of inositol, collagen, glycerin, betaine, panthenol, glyceryl acrylate / acrylic acid copolymer, PVM / MA copolymer, butylene glycol, and 1,2-hexanediol.

[0036] Inositol and collagen in the moisturizing components work synergistically to build the skin's moisturizing mechanism.

[0037] More preferably, the above collagen is recombinant type XVII collagen.

[0038] More preferably, the above-mentioned moisturizing component includes the following components calculated by mass:

[0039] Inositol 0.05-2 parts, collagen 0.0001-0.1 parts, glycerin 1-10 parts, betaine 0.1-5 parts, panthenol 0.1-10 parts, glyceryl acrylate / acrylic acid copolymer 0.00099-0.0297 parts, PVM / MA copolymer 0.00062-0.0186 parts 、 1 to 10 parts of butanediol and 0.1 to 2 parts of 1,2-hexanediol.

[0040] More preferably, the above-mentioned moisturizing component includes the following components calculated by mass:

[0041] Inositol 0.1-1 part, collagen 0.0002-0.05 part, glycerin 2-8 parts, betaine 0.2-3 parts, panthenol 0.2-5 parts, glyceryl acrylate / acrylic acid copolymer 0.00495-0.0198 parts, PVM / MA copolymer 0.0031-0.0124 parts 、 1.5 to 5 parts of butanediol and 0.2 to 1 part of 1,2-hexanediol.

[0042] More preferably, the above-mentioned moisturizing component includes the following components calculated by mass:

[0043] Inositol 1 part, collagen 0.001 part, glycerin 4 parts, betaine 1 part, panthenol 0.5 parts, glyceryl acrylate / acrylic acid copolymer 0.0099 parts, PVM / MA copolymer 0.0062 parts 、 3 parts of butanediol and 0.8 parts of 1,2-hexanediol.

[0044] Preferably, the skin conditioning agent in the soothing and revitalizing essence milk includes at least one of carboxymethyl chitosan, sodium hyaluronate, and buddleja buddleja extract.

[0045] It should be noted that the schizophyllan, biosaccharide gum-4, collagen, artemisia annua extract, sodium di(laurylamide glutamine) lysine and cholesterol in the soothing and revitalizing essence lotion provided by the present invention can also play a certain role as skin conditioners.

[0046] More preferably, the skin conditioning agent comprises the following components calculated by mass:

[0047] 0.01-1 parts of carboxymethyl chitosan, 0.01-0.3 parts of sodium hyaluronate, and 0.001-2 parts of Buddleja buddleja extract.

[0048] More preferably, the skin conditioning agent comprises the following components calculated by mass:

[0049] 0.05-0.5 parts of carboxymethyl chitosan, 0.02-0.2 parts of sodium hyaluronate, and 0.01-1 parts of Buddleja buddleja extract.

[0050] More preferably, the skin conditioning agent comprises the following components calculated by mass:

[0051] 0.2 parts of carboxymethyl chitosan, 0.101 parts of sodium hyaluronate, and 0.1 parts of Buddleja buddleja extract.

[0052] Preferably, the chelating agent in the soothing and revitalizing essence lotion includes disodium EDTA.

[0053] More preferably, the mass fraction of the chelating agent in the soothing and revitalizing essence lotion is 0.02-0.08 parts.

[0054] More preferably, the mass fraction of the chelating agent in the soothing and revitalizing essence lotion is 0.05 parts.

[0055] Preferably, the thickener in the soothing and revitalizing essence includes polyacrylate crosspolymer-6.

[0056] More preferably, the mass fraction of the thickener in the soothing and revitalizing essence milk is 0.1-0.8 parts.

[0057] More preferably, the mass fraction of the thickener in the soothing and rejuvenating essence milk is 0.5 parts.

[0058] More preferably, the emulsifier in the soothing and revitalizing essence milk includes an olive oil ester emulsifier.

[0059] More preferably, the mass fraction of the emulsifier in the soothing and revitalizing essence lotion is 0.2-2 parts.

[0060] More preferably, the mass fraction of the emulsifier in the soothing and rejuvenating essence lotion is 1.2 parts.

[0061] More preferably, the emollient in the soothing and revitalizing essence lotion includes at least one of dimethicone, olive (OLEAEUROPAEA) fruit oil, caprylic / capric triglyceride, rice (ORYZA SATIVA) germ oil, and hydrogenated polyisobutene.

[0062] It should be noted that the avocado tree (BUTYROSPERMUM PARKII) fruit butter in the soothing and revitalizing essence lotion of the present invention can also act as an emollient.

[0063] More preferably, the emollient comprises the following components calculated by mass:

[0064] 0.1-8 parts of polydimethylsiloxane, 0.1-10 parts of olive oil, 0.1-10 parts of caprylic / capric triglyceride, 0.1-5 parts of rice germ oil, and 0.1-8 parts of hydrogenated polyisobutene.

[0065] More preferably, the emollient comprises the following components calculated by mass:

[0066] 0.5-5 parts of polydimethylsiloxane, 1-8 parts of olive oil, 1-8 parts of caprylic / capric triglyceride, 0.2-3 parts of rice germ oil, and 0.5-5 parts of hydrogenated polyisobutene.

[0067] More preferably, the emollient comprises the following components calculated by mass:

[0068] 2.5 parts of polydimethylsiloxane, 4 parts of olive fruit oil, 5 parts of caprylic / capric triglyceride, 1.5 parts of rice germ oil, and 2 parts of hydrogenated polyisobutene.

[0069] More preferably, the antioxidant in the soothing and rejuvenating essence milk includes at least one of tocopherol acetate and p-hydroxyacetophenone.

[0070] It should be noted that the glucosylrutin in the soothing and revitalizing essence milk of the present invention can also act as an antioxidant.

[0071] More preferably, the antioxidant comprises the following components calculated by mass:

[0072] Tocopherol acetate 0.01-2 parts, p-hydroxyacetophenone 0.1-1 parts.

[0073] More preferably, the antioxidant comprises the following components calculated by mass:

[0074] Tocopherol acetate 0.1-1 part, p-hydroxyacetophenone 0.2-0.8 part.

[0075] It should be noted that the antioxidant p-hydroxyacetophenone in the soothing and revitalizing essence lotion of the present invention and the butylene glycol and 1,2-hexanediol in the moisturizing components can act synergistically to play the role of preservatives.

[0076] Preferably, the solvent in the soothing and revitalizing essence lotion includes water.

[0077] More preferably, the mass fraction of the above-mentioned solvent is 70 to 75 parts.

[0078] More preferably, the mass fraction of the above solvent is 72.328 parts.

[0079] In a specific embodiment of the present invention, the soothing and revitalizing essence milk may include the following components calculated by weight:

[0080] Water 65-80 parts, glycerin 1-10 parts, inositol 0.05-2 parts, sodium hyaluronate 0.01-0.3 parts, disodium EDTA 0.01-0.1 parts, betaine 0.1-5 parts, glyceryl acrylate / acrylic acid copolymer 0.00099-0.0297 parts, PVM / MA copolymer 0.00062-0.0186 parts, panthenol 0.1-10 parts, carboxymethyl deacetylated chitosan 0.01-1 parts, caesalpinia spinosa gum 0.01-0.5 parts, polyacrylate crosspolymer-6 0.01-1 parts, di(laurylamide glutamine) sodium lysine 0.0029-0.29 parts, olive oil ester emulsifier 0.1-3 parts, polydimethylsiloxane 0.1-8 parts, olive oil 0.1-10 parts, avocado tree butter 0.1-10 parts, caprylic / capric triglyceride 0.1-10 parts, rice germ oil 0.1-5 parts, hydrogenated polyisobutene 0.1-8 parts, cholesterol 0.01-2 parts, tocopherol acetate 0.01-2 parts, artemisia annua extract 0.01-2 parts, butylene glycol 1-10 parts, p-hydroxyacetophenone 0.1-1 parts, 1,2-hexanediol 0.1-2 parts, biosaccharide gum-4

[0081] 0.1-3 parts, schizophyllan 0.1-10 parts, buddleja extract 0.001-2 parts, glucosylrutin 0.001-0.3 parts, collagen 0.0001-0.1 parts.

[0082] In a specific embodiment of the present invention, the components in the soothing and revitalizing essence milk are divided into the following phases:

[0083] Phase A: Water, Glycerin, Inositol, Sodium Hyaluronate, Disodium EDTA, Betaine, Glyceryl Acrylate / Acrylic Acid Copolymer, PVM / MA Copolymer, Panthenol, Carboxymethyl Chitosan, Caesalpinia Spinosa Gum, Polyacrylate Crosspolymer-6, Sodium Di(Lauryl Glutamine) Lysine;

[0084] Phase B: Cetearyl Olivate, Sorbitan Olivate, Dimethicone, Olive Oil, Butyrospermum Parkii Butter, Caprylic / Capric Triglyceride, Rice Germ Oil, Hydrogenated Polyisobutene, Cholesterol, Tocopheryl Acetate, Artemisia Annua Extract;

[0085] Phase C: butanediol, p-hydroxyacetophenone, 1,2-hexanediol;

[0086] Phase D: biosaccharide gum-4, schizophyllan, buddleja extract;

[0087] Phase E: Glucosylrutin, collagen, water.

[0088] In a specific embodiment of the present invention, the preparation method of the soothing and revitalizing essence lotion comprises the following steps:

[0089] S1. Mix the components of phases A and B at 82 to 85° C. and homogenize to obtain emulsion 1;

[0090] S2. adding phase C to emulsion 1 at 60-65° C. to obtain emulsion 2;

[0091] S3. Add phases D and E to lotion 2 at 42-45°C to obtain a soothing and revitalizing essence lotion.

[0092] More specifically, in step S1, component A is first homogenized at 82-85° C., and then kept warm for 5-10 minutes. Phase B is then dissolved at 82-85° C., and phase B is added to phase A for homogenization for 5-10 minutes to obtain emulsion 1.

[0093] More specifically, in step S2, phase C is first dissolved at 80-85°C, and then phase C is added to emulsion 1 at 60-65°C.

[0094] Compared with the prior art, the present invention has the following beneficial effects:

[0095] The soothing and revitalizing essence lotion provided by the present invention has a significant moisturizing effect. After being used for 28 days, the water content of the stratum corneum of human skin can be increased by more than 50.97%, and the transepidermal water loss value can be reduced by more than 10.3%; because the bionic sebum film composition can repair the skin barrier, the essence lotion of the present invention also has an excellent soothing effect, which can reduce the hemoglobin content of human facial skin by more than 12.37%, and the facial red zone area can be reduced by at least 10.26%. DETAILED DESCRIPTION

[0096] The present invention is further described below in conjunction with specific embodiments, but the embodiments do not limit the present invention in any form. Unless otherwise specified, the raw materials and reagents used in the embodiments of the present invention are conventionally purchased raw materials and reagents.

[0097] The raw material information of the embodiments and comparative examples of the present invention are as follows:

[0098] Glycerin: SWAN BRAND GLYCERINE USP, purchased from PALMEDIA (M) SDN.BHD.;

[0099] Inositol: OSMS MI, purchased from Finnfeeds Finland Oy;

[0100] Sodium Hyaluronate: Sodium hyaluronate was purchased from Shandong Focus Freda Biological Co., Ltd.;

[0101] Disodium EDTA: Dissolvine Na2, purchased from Nouryon Chemicals (Ningbo) Co., Ltd.;

[0102] Betaine: OSMS BA, purchased from Finnfeeds Finland Oy;

[0103] Glyceryl acrylate / acrylic acid copolymer: lubrajel*oil pf hydrogel, purchased from UNITED-GUARDIAN, INC., the content of glyceryl acrylate / acrylic acid copolymer in this product is 0.99wt%;

[0104] PVM / MA copolymer: lubrajel*oil pf hydrogel, purchased from UNITED-GUARDIAN, INC., the content of PVM / MA copolymer in the product is 0.62wt%;

[0105] Panthenol: D-Panthenol / D-Panthenol 99USP (version number V01), purchased from DSM Nutritional Products Ltd. / DSM Nutritional Products Ltd.;

[0106] Carboxymethyl chitosan: MHA Micro (version 5.2), purchased from Shanghai Chunlu Biochemical Co., Ltd.;

[0107] CAESALPINIA SPINOSA glue: SOLAGUM TARA, purchased from SEPPIC SA;

[0108] Polyacrylate crosspolymer-6: SEPIMAX ZEN, purchased from SEPPIC SA;

[0109] Sodium di(lauryl glutamine) lysinate: PELLICER TM L-30, purchased from ASAHI KASEI FINECHEMCO., LTD., wherein the content of the active ingredient di(laurylamide glutamine) sodium lysine is 29wt%;

[0110] Olive oil ester emulsifier: Olivem 1000, purchased from Hallstar Beauty and Personal Care Solutions Company;

[0111] Dimethicone: XIAMETER TM PMX-200Silicone Fluid 350cSt, purchased from Dow (Zhangjiagang) Investment Co., Ltd.;

[0112] Olive Oil: Lipovol TM O, purchased from Vantage Specialty Chemicals, Inc.;

[0113] Avocado tree (BUTYROSPERMUM PARKII) butter: Shea, purchased from AAK Sweden AB;

[0114] Caprylic / capric triglyceride: purchased from Wilmar Oil Technology (Lianyungang) Co., Ltd. / DUBOIS-NATURALESTERS SDN.BHD;

[0115] Rice (ORYZA SATIVA) germ oil: RICE GERM OIL (PRO-15), purchased from TSUNO FOODINDUSTRIAL CO., LTD.;

[0116] Hydrogenated polyisobutylene: SQUALANE SYN, purchased from Yichang Mingya New Material Technology Co., Ltd.;

[0117] Cholesterol: NB-626, purchased from Guangdong Gexin Biotechnology Co., Ltd.;

[0118] Tocopherol acetate: Vitamin E-Acetate Care, purchased from BASF (China) Co., Ltd.;

[0119] Artemisia annua extract: purchased from Hunan Xirui New Materials Co., Ltd.;

[0120] Butanediol: 1,3-butanediol, purchased from OQ Chemicals corporation;

[0121] 4-Hydroxyacetophenone: H(672096) / H (979940), purchased from Dezhixin Flavors & Fragrances (Nantong) Co., Ltd. / Dezhixin Flavors & Fragrances (Nantong) Co., Ltd.;

[0122] 1,2-Hexanediol: 6O, purchased from Dezhixin Flavors & Fragrances (Nantong) Co., Ltd.;

[0123] Biosaccharide Gum-4: Sugar film protective agent UP, purchased from SOLABIA GROUP;

[0124] Schizophyllin: purchased from Ningbo Glucagon Biotechnology Co., Ltd.;

[0125] Buddleja officinalis extract: SOLIBERINE NAT (001173), purchased from GREENTECH SA;

[0126] Glucosylrutin: purchased from Qingdao Taidong Pharmaceutical Co., Ltd.;

[0127] Collagen: Recombinant type XVII collagen TTB01-02SC was purchased from Jiangsu Chuangjian Medical Technology Co., Ltd.

[0128] Examples 1 to 7

[0129] This embodiment provides a series of bionic sebum film compositions with different component proportions, and the specific component weight fractions are shown in the following Table 1:

[0130] Table 1. Mass fractions of each component in Examples 1 to 7

[0131] Mass fraction x y z Example 1 3.5 0.2 0.029 Example 2 3.646 0.073 0.011 Example 3 1.738 1.738 0.252 Example 4 3.724 0.0037 0.0011 Example 5 0.156 3.121 0.452 Example 6 2.891 0.826 0.0120 Example 7 3.485 0.100 0.144

[0132] Note: In Table 1 above, x represents the mass fraction of avocado oil, y represents the mass fraction of cholesterol, and z represents the mass fraction of sodium di(laurylamideglutamine)lysine.

[0133] Comparative Examples 1 to 9

[0134] This comparative example provides a series of bionic sebum film compositions with different component proportions, and the specific component weight fractions are shown in Table 2 below:

[0135] Table 2. Mass fractions of each component in Comparative Examples 1 to 9

[0136]

[0137]

[0138] Note: In Table 2 above, x represents the mass fraction of avocado oil, y represents the mass fraction of cholesterol, and z represents the mass fraction of sodium di(laurylamide glutamine) lysine.

[0139] Comparative Example 10

[0140] A bionic sebum film composition, which is different from Example 1 only in that:

[0141] Replace avocado butter with an equal amount of lecithin.

[0142] Comparative Example 11

[0143] A bionic sebum film composition, which is different from Example 1 only in that:

[0144] Replace avocado butter with an equal amount of cocoa (THEOBROMA CACAO) seed butter.

[0145] Comparative Example 12

[0146] A bionic sebum film composition, which is different from Example 1 only in that:

[0147] Sodium di(laurylamide glutamine) lysine was replaced with an equal mass of ceramide-1.

[0148] Examples 8 to 14 and Comparative Examples 13 to 24

[0149] The bionic sebum film compositions obtained in Examples 1 to 7 were mixed with other components to prepare the soothing and revitalizing essence lotions of Examples 8 to 14; the bionic sebum film compositions obtained in Comparative Examples 1 to 12 were mixed with other components to prepare the essence lotions of Comparative Examples 13 to 24.

[0150] The present embodiment and comparative example provide a series of methods for preparing essence milks with different component types and weight fractions, comprising the following steps:

[0151] S1. Add phase A material to an emulsifier, heat to 83°C, stir and homogenize, and keep warm for 8 minutes. Then add phase B material to an oil pan, heat to 83°C until completely dissolved, then pump into an emulsifier and mix with phase A. Stir and homogenize for 8 minutes until the material is uniform to obtain emulsion 1.

[0152] S2. dissolving phase C at 83°C and adding phase C to emulsion 1 at 62°C to obtain emulsion 2;

[0153] S3. Add phases D and E to emulsion 2 at 43°C to obtain essence emulsion.

[0154] The essence milks obtained in Examples 8 to 14 and Comparative Examples 13 to 24 specifically include the components calculated by mass as shown in Table 3 below:

[0155] Table 3. Components and their mass fractions in the essence milks of Examples 8 to 14 and Comparative Examples 13 to 24

[0156]

[0157]

[0158] Note:

[0159] 1. The mass fractions x, y, and z of the bionic sebum membrane components in the essence lotions obtained in Examples 8 to 14 in Table 3 above are respectively taken according to Table 1;

[0160] 2. The mass fractions x, y and z of the bionic sebum membrane components in the essence lotions obtained in Comparative Examples 13 to 24 in Table 3 above are respectively taken according to Table 2.

[0161] Performance Testing

[0162] Next, human body experiments were conducted using the essence lotions obtained in Examples 8 to 14 and Comparative Examples 13 to 24 to explore their moisturizing and repairing effects.

[0163] 1. Human experiments and related index determination:

[0164] 30 volunteers were recruited to continuously use the product provided by the present invention and to evaluate the moisturizing and repairing effects of the essence lotions obtained in the embodiments and comparative examples through instrument testing.

[0165] 1. The inclusion criteria are as follows:

[0166] 1.1. Subjects must be between 30 and 60 years old, in good general health, regardless of gender;

[0167] 1.2. Those who can strictly follow the requirements and schedule of the research plan, voluntarily participate in the trial and obtain informed consent;

[0168] 1.3. Those who feel that their skin is dry, flaky, red, or has other symptoms of impaired skin barrier function;

[0169] 1.4. Those who feel that their skin is sagging and have obvious crow's feet or wrinkles on their face.

[0170] 2. Test site: face.

[0171] 3.Related indicator test methods:

[0172] 3.1. Human body moisture content test: The skin moisture test probe Corneometer provided by Courage-Khazaka of Germany was used to test the moisture content of the skin stratum corneum of volunteers on the 0th day and the 28th day of continuous use of this product. The average value was taken to calculate the rate of change.

[0173] 3.2. Transepidermal water loss (TEWL) test: The transepidermal water loss probe Tewameter TM Hex provided by Courage-Khazaka of Germany was used to test the transepidermal water loss values ​​of volunteers on the 0th day and the 28th day of continuous use of this product. The change rate was calculated by taking the average value.

[0174] 3.3. Skin hemoglobin content test: The skin hemoglobin content of volunteers on the 0th day and the 28th day of continuous use of this product was tested using the skin hemoglobin tester Mexameter provided by Courage-Khazaka of Germany. The average value was taken to calculate the change rate of skin hemoglobin content.

[0175] 3.4. Facial red zone area test: The PRIMOS CR skin three-dimensional imaging system produced by CANFIELD of the United States was used to perform three-dimensional imaging of the faces of volunteers on day 0 and day 28 of continuous use of this product. The facial red zone area test was performed using VISIA 7, a facial imaging analysis system produced by CANFIELD of the United States. The rate of change was calculated by taking the average value.

[0176] The performance test data is shown in Table 4 below:

[0177] Table 4. Test data of the essence milk obtained in the examples and comparative examples

[0178]

[0179]

[0180] According to the data in Table 4 above, it can be seen that the soothing and revitalizing essence milk provided by the present invention has a significant moisturizing effect. After 28 days of use, the water content of the stratum corneum of human skin can be increased by more than 50.97%, and the transepidermal water loss value can be reduced by more than 10.3%; because the bionic sebum film composition can repair the skin barrier, the essence milk of the present invention also has an excellent soothing effect, which can reduce the hemoglobin content of human facial skin by more than 12.37%, and the facial red area can be reduced by at least 10.26%. Among them, according to the data of Examples 8 to 14, it can be seen that when the mass ratio of each component in the bionic sebum film composition is avocado tree fat: cholesterol: sodium di(laurylamide glutamine) lysine = (1 to 5): (0.1 to 1): (0.05 to 0.5) (Examples 8 to 10, 13 to 14), the obtained essence milk has a more excellent moisturizing and repairing effect. According to the data of Comparative Examples 13 to 15, it can be seen that the lack of any component in the bionic sebum film composition will result in the component being unable to fully exert the deep moisturizing and soothing effects in the essence milk system of the present invention, especially when avocado tree fat is lacking (Comparative Example 15, corresponding to Comparative Example 3), the moisturizing and soothing effect of the obtained essence milk is the worst. According to the data of Comparative Examples 16 to 21, it can be seen that the proportion of each component in the bionic sebum film composition of the present invention has an important influence on the moisturizing and repairing effect of the composition. The three components, no matter which one is too much or too little, will cause the moisturizing and soothing repair performance of the essence milk to be greatly reduced. According to the effects of Comparative Examples 22 to 24, when any component in the bionic sebum film composition of the present invention is replaced with other components with similar functions, the moisturizing and repairing performance of the essence milk is reduced, indicating that there is a synergistic effect between the components in the composition provided by the present invention.

[0181] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A bionic sebum film composition, characterized in that: It includes the following components calculated by mass: 0.1-10 parts of avocado butter, 0.01-2 parts of cholesterol, and 0.0029-0.29 parts of sodium di(laurylamide glutamine) lysine.

2. The biomimetic sebum film composition according to claim 1, characterized in that: It includes the following components calculated by mass: 1-5 parts of avocado butter, 0.1-1 parts of cholesterol, 0.0145-0.145 parts of sodium di(laurylamide glutamine) lysine.

3. The method for preparing the bionic sebum film composition according to claim 1 or 2, characterized in that: The steps include: A bionic sebum membrane composition can be obtained by uniformly mixing avocado tree fat, cholesterol and sodium di(laurylamide glutamine) lysine in a certain proportion at T°C, wherein T≥80°C.

4. A soothing and revitalizing essence lotion, characterized in that: It includes the following components calculated by mass: The bionic sebum film composition comprises 0.11 to 13 parts, a light protection component 0.201 to 13.3 parts, a soothing component 0.11 to 12 parts, a moisturizing component 0.0501 to 20 parts, a skin conditioner 0.021 to 3.3 parts, a chelating agent 0.01 to 0.1 parts, a thickener 0.01 to 0.1 parts, an emulsifier 0.1 to 3 parts, an emollient 0.5 to 41 parts, an antioxidant 0.11 to 3 parts and a solvent 65 to 80 parts.

5. The soothing and revitalizing essence lotion according to claim 4, characterized in that: Including at least one of the following (a) to (j): (a) the photoprotective component comprises at least one of glucosylrutin, taro gum and biosaccharide gum-4; (b) the soothing component comprises at least one of an Artemisia annua extract and schizophyllan; (c) the moisturizing component comprises at least one of inositol, collagen, glycerin, betaine, panthenol, glyceryl acrylate / acrylic acid copolymer, PVM / MA copolymer, butylene glycol, and 1,2-hexanediol; (d) the skin conditioning agent comprises at least one of carboxymethyl chitosan, sodium hyaluronate, and Buddleja buddleja extract; (e) the chelating agent comprises disodium EDTA; (f) the thickener comprises polyacrylate cross-linked polymer-6; (g) the emulsifier comprises an olive oil ester emulsifier; (h) the emollient comprises at least one of dimethicone, olive oil, caprylic / capric triglyceride, rice germ oil, and hydrogenated polyisobutene; (i) the antioxidant comprises at least one of tocopherol acetate and p-hydroxyacetophenone; (j) The solvent comprises water.

6. The soothing and revitalizing essence lotion according to claim 5, characterized in that: The light protection component includes the following components calculated by mass: 0.001-0.3 parts of glucosylrutin, 0.01-0.5 parts of taro gum, and 0.1-3 parts of biosaccharide gum-4.

7. The soothing and revitalizing essence lotion according to claim 5, characterized in that: The soothing component includes the following components calculated by mass: 0.01-2 parts of Artemisia annua extract and 0.1-10 parts of schizophyllanthus.

8. The soothing and revitalizing essence lotion according to claim 5, characterized in that: The moisturizing component includes the following components calculated by mass: Inositol 0.05-2 parts, collagen 0.0001-0.1 parts, glycerin 1-10 parts, betaine 0.1-5 parts, panthenol 0.1-10 parts, glyceryl acrylate / acrylic acid copolymer 0.00099-0.0297 parts, PVM / MA copolymer 0.00062-0.0186 parts 、 1 to 10 parts of butanediol and 0.1 to 2 parts of 1,2-hexanediol.

9. The soothing and revitalizing essence lotion according to claim 5, characterized in that: The skin conditioning agent comprises the following components calculated by mass: 0.01-1 parts of carboxymethyl chitosan, 0.01-0.3 parts of sodium hyaluronate, and 0.001-2 parts of Buddleja buddleja extract.

10. The soothing and revitalizing essence lotion according to claim 5, characterized in that: The emollient comprises the following components calculated by mass: 0.1-8 parts of polydimethylsiloxane, 0.1-10 parts of olive oil, 0.1-10 parts of caprylic / capric triglyceride, 0.1-5 parts of rice germ oil, and 0.1-8 parts of hydrogenated polyisobutene.

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