Plant seed meal sourced red-removing and whitening transporter for skin as well as preparation method and application of plant seed meal sourced red-removing and whitening transporter

Abstract

The invention discloses a red-removing and whitening conveying body for skin and a preparation method and application of the red-removing and whitening conveying body. The red-removing and whitening conveying body is prepared from special liquid serving as a phase A; an ionic liquid mixture of plant seed meal active matters serves as a phase B, an emulsifier and water are mixed to serve as a phase C, micro-emulsion is prepared according to a pseudo-ternary phase diagram method, the plant seed meal active matters comprise grape seed meal, peony seed meal and tea seed meal in a ratio of 2: 1: 1, and the transporter can be applied to cosmetics as a red-removing and whitening component.

Description

Technical Field

[0001] The invention belongs to the technical field of micro-nano carriers, and in particular relates to a skin redness-removing and whitening carrier derived from plant seed cakes, and a preparation method and application thereof. Background Art

[0002] Grape seed meal is rich in polyphenols, linoleic acid, amino acids, multiple vitamins, crude fat, and trace elements. Among them, proanthocyanidins (OPC) are the main substance in polyphenols and have super antioxidant capacity, which is 50 times that of vitamin E and 20 times that of vitamin C.

[0003] Peony seed meal is the remaining cake after peony seed oil production, which contains a large amount of unsaturated fatty acids, phytosterols, monoterpenoids (peonidin, oxypeonidin, etc.), flavonoids (apigenin, quercetin, etc.), stilbene compounds (resveratrol, polydatin, etc.), polysaccharides, etc. Tea seed meal is a by-product after tea extraction, rich in tea saponins, tea polysaccharides, tea polyphenols, flavonoids and other active ingredients.

[0004] At present, these plant seed meals are used as by-products in feed, food, medicine and other industries. Their comprehensive utilization and development are gradually attracting people's attention. However, there are few reports on their application in the cosmetics industry, mainly due to the problems of low bioavailability and poor efficacy targeting. Summary of the invention

[0005] The purpose of this section is to summarize some aspects of embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the specification abstract and the invention title of this application to avoid blurring the purpose of this section, the specification abstract and the invention title, and such simplifications or omissions cannot be used to limit the scope of the present invention.

[0006] In view of the above problems and / or the problems existing in the prior art, the present invention is proposed.

[0007] Therefore, the purpose of the present invention is to overcome the deficiencies in the prior art and provide a method for preparing a skin redness-removing and whitening transporter derived from plant seed meal.

[0008] In order to solve the above technical problems, the present invention provides the following technical solutions: a method for preparing a skin redness-removing and whitening transporter derived from plant seed meal, comprising:

[0009] Take the oil as phase A;

[0010] The ionic liquid mixture of plant seed meal active ingredients is used as phase B;

[0011] Mix the emulsifier and water as phase C;

[0012] A, B and C were used as the three vertices of the pseudo-ternary phase diagram, and a pseudo-ternary phase diagram was drawn. The microemulsion was prepared according to the pseudo-ternary phase diagram method.

[0013] Wherein, based on the total mass percentage of the raw materials, the phase A is 3-10%, the phase B is 10-20%, and the balance is the phase C to make up to 100%;

[0014] The microemulsion preparation temperature is 60-70°C.

[0015] As a preferred embodiment of the preparation method of the present invention, the plant seed meal active ingredients include one or more of grape seed meal extract, peony seed meal extract and tea seed meal extract.

[0016] As a preferred embodiment of the preparation method of the present invention, the plant seed meal extract is a composition of grape seed meal, peony seed meal and tea seed meal, wherein the mass ratio of grape seed meal, peony seed meal and tea seed meal is 2:1:1.

[0017] As a preferred embodiment of the preparation method of the present invention, the preparation method of the plant seed meal extract comprises:

[0018] Weigh the plant seed meal, crush it, and sieve it to obtain fine powder, use petroleum ether to defatting treatment, collect the solid residue, and place it in a ventilated place to allow the residual solvent to evaporate naturally, so as to obtain defatted plant seed meal powder;

[0019] The defatted plant seed meal powder is mixed with a phosphate buffer solution with a pH of 8.0 at a mass ratio of 1:5, and 2% to 3% of papain is added, and the mixture is reacted at 40 to 45°C for 4 to 6 hours;

[0020] After the reaction was completed, the reaction was inactivated under high pressure at 121°C for 20 minutes;

[0021] The inactivated enzyme solution is filtered and concentrated, and the concentrated liquid is rotary dried to obtain a milky white powder, which is the plant seed meal extract.

[0022] As a preferred embodiment of the preparation method of the present invention, the ionic liquid comprises lysophosphatidylcholine, glutamic acid, proline and deionized water;

[0023] The molar ratio of lysophosphatidylcholine, glutamic acid and proline is 2:4:3.

[0024] As a preferred embodiment of the preparation method of the present invention, the preparation method of the ionic liquid comprises:

[0025] Lysophosphatidylcholine, glutamic acid and proline were mixed, dissolved in water, stirred at 60°C to obtain a light yellow liquid, and stirred and balanced at room temperature for 24 hours. The mixture was vacuum dried to obtain a yellow viscous transparent ionic liquid after removing moisture.

[0026] As a preferred embodiment of the preparation method of the present invention, the preparation method of phase B comprises:

[0027] The plant seed meal active ingredients were added into the ionic liquid at a mass ratio of 1:4, and stirred at room temperature until completely transparent to obtain phase B.

[0028] As a preferred embodiment of the preparation method of the present invention, the oil includes one or more of polyperfluoromethyl isopropyl ether and cyclopentasiloxane, and the emulsifier includes one or more of PPG-6-decyltetradecyl alcohol polyether-30, cetearyl alcohol polyoxyethylene ether-6, cetearyl alcohol polyoxyethylene ether-25 and PEG-20 phytosterol.

[0029] Another object of the present invention is to overcome the deficiencies in the prior art and provide a skin redness-removing and whitening delivery medium derived from plant seed meal.

[0030] Another object of the present invention is to overcome the deficiencies in the prior art and provide a plant seed meal-derived skin redness-removing and whitening transporter for use in the preparation of redness-removing and whitening cosmetics, wherein the redness-removing and whitening cosmetics are selected from one or more of facial cleansers, facial masks, lotions, emulsions, creams, and essences.

[0031] Beneficial effects of the present invention:

[0032] (1) The plant seed meal-derived skin whitening carrier prepared by the present invention can combine the dual advantages of microemulsion and ionic liquid by introducing ionic liquid into the microemulsion system. On the basis of maintaining the characteristics of traditional microemulsion, it can also significantly improve its solubilization and penetration-promoting ability and thermal stability, thus overcoming the defect that traditional microemulsion cannot dissolve a variety of water-insoluble drugs.

[0033] (2) The plant seed meal-derived skin whitening carrier prepared by the present invention can be dissolved in water to obtain a transparent solution, which can be applied to various dosage forms of cosmetic formulas and is easy to add and store.

[0034] (3) The plant seed meal-derived skin whitening carrier of the present invention has the effect of whitening and whitening, can greatly increase the solubility of active substances in water, and at the same time improve its transdermal effect and increase its bioavailability. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative labor. Among them:

[0036] Figure 1 This is the pseudo ternary phase diagram of the microemulsion sample prepared in Example 1 of the present invention.

[0037] Figure 2 This is a diagram showing the transdermal results of the sample in Example 2 of the present invention.

[0038] Figure 3 The particle size measurement results of the samples in Example 3 of the present invention are shown in FIG.

[0039] Figure 4 This is the TEM image of the sample in Example 3 of the present invention.

[0040] Figure 5 The stability test results of the samples in Example 4 of the present invention are shown.

[0041] Figure 6 This is the test result of melanin content in Example 6 of the present invention.

[0042] Figure 7 It is the pseudo ternary phase diagram of the microemulsion sample prepared in Comparative Example 1 of the present invention.

[0043] Figure 8 This is the test result of melanin content in comparative example 1 of the present invention. DETAILED DESCRIPTION

[0044] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the embodiments of the specification.

[0045] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0046] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The term "in one embodiment" that appears in different places in this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive with other embodiments.

[0047] Example 1

[0048] The samples were prepared according to the raw material ratios in Table 1.

[0049] Table 1 Raw material ratio table (unit: %)

[0050]

[0051] Note: ●: turbid; ○: transparent

[0052] Mix and dissolve the liquid oil to obtain phase A;

[0053] Preparation of ionic liquids:

[0054] Lysophosphatidylcholine, glutamate, and proline were purchased from the MacLean reagent platform.

[0055] A total of 100 g of lysophosphatidylcholine, glutamic acid and proline were mixed in a molar ratio of 2:4:3, dissolved in 100 g of water, and stirred at 60°C to obtain a light yellow liquid. The mixture was stirred and balanced at room temperature for 24 hours, and dried in vacuo to remove moisture to obtain a yellow viscous transparent ionic liquid.

[0056] A mixture obtained by dissolving the plant seed meal active ingredient in the ionic liquid is used as phase B;

[0057] Preparation of plant seed meal active ingredients: 100 g of plant seed meal (grape seed meal, peony seed meal, tea seed meal) were weighed respectively, according to a mass ratio of 2:1:1, and then crushed and sieved through a 300-mesh sieve to obtain fine powder, and then defatted with petroleum ether, and then the solid residue was collected and placed in a ventilated place to allow the residual solvent to evaporate naturally;

[0058] The defatted plant seed meal was mixed with a phosphate buffer solution with a pH of 8.0 at a ratio of 1:5, and 3% papain (100 KU) was added, and then reacted at 42°C for 5 hours;

[0059] After the reaction was completed, the reaction was inactivated under high pressure at 121°C for 20 min;

[0060] Afterwards, the mixture was filtered using PES (polyethersulfone)-1000KDa and PES-10KDa membranes in turn, and the filtrate was concentrated using RC (regenerated fiber)-5KDa. Finally, the concentrated liquid was dried using a rotary evaporator to obtain a milky white powder, which was the plant seed meal active ingredient.

[0061] Mix the emulsifier and water to form phase C;

[0062] The phase A and phase B were mixed at a mass ratio of 1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 7:3, 8:2, and 9:1, and phase C was added dropwise under stirring to record the mass fraction of each phase at the critical point. The phase A, phase B, and phase C were used to prepare a microemulsion according to the pseudo-ternary phase diagram method.

[0063] The pseudo-ternary phase diagram of the microemulsion sample prepared from sample 1 is shown in Figure 1 .

[0064] The results show that the emulsifier, oil and active ingredient content in samples 3, 4 and 5 is not appropriate, and the emulsions formed have no transparent phase region. Samples 1 and 2 can form microemulsions and can achieve transparency after water dilution.

[0065] Example 2

[0066] For transdermal experiments, the sample settings are shown in Table 2.

[0067] Table 2

[0068] Sample A Proanthocyanidin aqueous solution Sample B Sample No. 1 in Example 1

[0069] Experimental methods:

[0070] The content of proanthocyanidins in sample B was determined by high performance liquid chromatography. An aqueous solution of proanthocyanidins with the same mass content was prepared and the proanthocyanidins were weighed and dissolved in pure water.

[0071] In the whole experiment, intact and undamaged pig skin of equal thickness was selected for transdermal experiment. The pig skin was cut into pieces of about 2.5 cm × 2.5 cm in size and placed between the receiving pool and the supply pool of the Franz diffusion cell, with the stratum corneum facing the supply pool.

[0072] The receiving pool contained PBS buffer (pH = 7.4) containing 5% Tween 80;

[0073] Add 2 mL of the sample to be tested into the supply cell;

[0074] The assembled Franz diffusion cell was placed in the transdermal diffusion instrument, and the experimental conditions were set as follows: temperature was 37°C, stirring speed was 400 rpm, and transdermal time was 12 h.

[0075] After the transdermal test, the pigskin was taken out of the diffusion cell, and the residual sample on the surface of the pigskin was wiped clean with absorbent cotton. Then, the tape stripping method was used to determine the content of Dendrobium polysaccharide in the stratum corneum. 21 layers of skin on the surface of the pigskin were taped with 3M tape, the first layer was discarded, and the remaining 20 layers were placed in a 15mL centrifuge tube. 2mL of isopropanol was first added to the tube, ultrasonicated for 30min, and centrifuged at 5000rpm for 30min. The supernatant was filtered with a 0.22μm organic filter membrane, and the content of proanthocyanidins was determined, which was the content of proanthocyanidins in the stratum corneum.

[0076] The remaining skin surface was heated at 60°C for 15s, and the viable epidermis was carefully cut off with a scalpel, shredded and placed in a 15mL centrifuge tube, 2mL of isopropanol was added, ultrasonicated for 30min, and centrifuged at 5000rpm for 30min. The supernatant was filtered with a 0.22μm organic filter membrane and the proanthocyanidin content was determined, which was the proanthocyanidin content in the viable epidermis.

[0077] The remaining skin was cut into pieces and placed in a 15 mL centrifuge tube. 2 mL of isopropanol was added and ultrasonicated for 30 min. Then, the tube was centrifuged at 5000 rpm for 30 min. The supernatant was filtered with a 0.22 μm organic filter membrane and the content of proanthocyanidins was determined. This was the content of proanthocyanidins in the dermis.

[0078] The content of proanthocyanidins was determined by high performance liquid chromatography.

[0079] The results of the transdermal test were as follows Figure 2 As shown, it can be seen from the results that the transdermal effect of the composition is greatly improved compared with the proanthocyanidin aqueous solution, both in the active epidermis and the dermis; the system effectively improves the transdermal absorption effect of the active substance proanthocyanidin and increases its bioavailability.

[0080] Example 3

[0081] Particle size determination and morphology characterization:

[0082] The particle size of the sample in Example 1 was measured using a nanoparticle size analyzer. Figure 3 .

[0083] The morphology of the sample in Example 1 was observed by TEM. Figure 4 .

[0084] from Figure 3 It can be seen that the average particle size of this sample is 55 nm.

[0085] from Figure 4 It can be seen that the sample is nanoparticles with uniform particle size.

[0086] Example 4

[0087] Stability test:

[0088] To investigate the stability of active ingredients in skin redness-removing and whitening delivery vehicles derived from plant seed meal.

[0089] Test method:

[0090] 1. Sample A: Sample 1 of Example 1, the contents of active ingredients proanthocyanidins and resveratrol in Sample 1 of Example 1 were determined by high performance liquid chromatography;

[0091] Proanthocyanidin content in sample 1: 0.0834% (mass content);

[0092] Resveratrol content in sample 1: 0.0506% (mass content).

[0093] 2. Sample B: aqueous solution of proanthocyanidins (proanthocyanidins dissolved in water, mass content 0.0834%)

[0094] 3. Sample C: ethanol solution of resveratrol (resveratrol dissolved in ethanol, mass content 0.0506%)

[0095] 4. Samples ABC were placed at 45°C for one month, and the content of active ingredients was determined by high performance liquid chromatography to investigate the stability of active ingredients under high temperature conditions.

[0096] The test results are shown in Figure 5 From the experimental results, it can be seen that under high temperature conditions, the stability of active ingredients in skin anti-redness and whitening carriers derived from plant seed meal is significantly improved compared to the free active ingredients.

[0097] Example 5

[0098] Determination of redness-removing activity:

[0099] HUVEC (human umbilical vein endothelial cell) cells were grown in complete ECM medium;

[0100] According to 1×10 5 The cells were seeded in a 6-well plate at a density of 1 mL / mL per well and cultured in a 37°C, 5% CO2 incubator. After incubation for 24 h, the cells were washed twice with PBS.

[0101] Sample preparation: 1 mg of each extract was dissolved in 1 mL of DMSO and diluted 10 times with ECM. Sample A1 was prepared by taking 400 μL of the grape seed meal extract dilution and making up the remainder to 1 mL with ECM.

[0102] Similarly, sample A5 was prepared by taking 100 μL of grape seed meal extract dilution, 200 μL of peony seed meal extract, and 100 μL of tea seed meal extract dilution, and the remainder was made up to 1 mL with ECM;

[0103] Samples A2, A3, A4, A6-A9 were also prepared in the same manner.

[0104] In the model group and sample group, 10 μL of ECM culture medium containing 10 μg / mL TNF-α was added to each well;

[0105] The sample group was added with 100 μL of the above sample ECM dilution solution;

[0106] After 24 hours, the culture medium was collected and centrifuged at 10,000 rpm for 10 minutes. The supernatant was taken and the VEGF level was detected using an ELISA kit (NOVUS). BSA was used to measure the protein content for calibration. Finally, the VEGF inhibition rate of the sample was calculated using the following formula:

[0107] VEGF inhibition rate % = (1-As / Ac) × 100%;

[0108] Among them, As and Ac are the VEGF levels in the sample group and model group, respectively.

[0109] The results are shown in Table 3.

[0110] Table 3

[0111] sample Grape Seed Meal Extract Peony Seed Meal Extract Tea seed meal extract VEGF inhibition rate% A1 4 0 0 30.17 A2 0 4 0 8.35 A3 0 0 4 10.98 A4 2 1 1 86.36 A5 1 2 1 63.91 A6 1 1 2 31.62 A7 2 2 0 18.84 A8 2 0 2 22.34 A9 0 2 2 19.06

[0112] It can be seen that the inhibition rate of VEGF after the three extracts were compounded was improved, especially the grape seed meal extract: peony seed meal extract: tea seed meal extract, which had the highest improvement at 2:1:1.

[0113] Example 6

[0114] Determination of melanin content:

[0115] To investigate the possibility of whitening activity of grape seed meal extract: peony seed meal extract: tea seed meal extract in a 2:1:1 ratio, the melanin content was determined by cell method.

[0116] Mouse skin melanoma cells (B16-F10) 1.5×10 51 μg / mL IBMX solution and 100 μL of sample solution diluted to 4000 / 2000 / 1000 ppm in DMEM medium were added to make the final system 400 / 200 / 100 ppm. After incubation for 48 hours, the 12-well plate was taken out, and the cells in each well were gently scraped with a cell scraper and collected into a centrifuge tube. Centrifuged at 8000 rpm for 10 minutes, the supernatant was discarded, and 100 μL of 1M NaOH solution containing 10% DMSO was added. The cells were resuspended by shaking and placed in a water bath at 80°C for 1 hour.

[0117] After cooling at room temperature, transfer to a 96-well plate and measure the absorbance at 405 nm using an ELISA reader. The ratio of the absorbance of the sample group to the absorbance of the blank group is used to represent the relative content of melanin.

[0118] Results Figure 6 It can be seen that the composition at a concentration of 100 ppm is equivalent to the drug control group of arbutin 200 ppm.

[0119] Comparative Example 1

[0120] Mix and dissolve the liquid oil to obtain phase A;

[0121] Preparation of plant seed meal active ingredients: Weigh 100g of plant seed meal, crush it and pass it through a 300-mesh sieve to obtain fine powder, then use petroleum ether to defatted it, then collect the solid residue and place it in a ventilated place to allow the residual solvent to evaporate naturally;

[0122] The defatted plant seed meal powder is mixed with a phosphate buffer solution with a pH of 8.0 at a ratio of 1:5, and 2%-3% of papain (100KU) is added, and then reacted at 40-45 degrees for 4-6 hours;

[0123] After the reaction was completed, the reaction was inactivated under high pressure at 121°C for 20 minutes;

[0124] Afterwards, PES (polyethersulfone)-1000KDa and PES-10KDa membranes were used for filtration in turn, and the filtrate was concentrated using RC (regenerated fiber)-5KDa. Finally, the concentrated liquid was dried using a rotary evaporator to obtain a milky white powder.

[0125] The plant seed meal active substance was dissolved in ethanol, stirred at 40°C for 4 hours, and the supernatant was taken as the mixture as phase B;

[0126] Mix the emulsifier and water to form phase C;

[0127] The phase A and phase B were mixed at a mass ratio of 1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 7:3, 8:2, and 9:1, and phase C was added dropwise under stirring to record the mass fraction of each phase at the critical point. The phase A, phase B, and phase C were used to prepare a microemulsion according to the pseudo-ternary phase diagram method.

[0128] The amount of raw materials added in this comparative example is consistent with the content in sample 1 in the embodiment, and its phase diagram is as follows Figure 7 shown.

[0129] Comparison of efficacy between sample 1 and comparison 1 in Example 1:

[0130] Melanin determination:

[0131] Mouse skin melanoma cells (B16-F10) 1.5×10 5 100 μL of 1 μg / mL IBMX solution and 100 μL of sample solution diluted to 4000 / 2000 / 1000 ppm in DMEM medium were added to make the final system 400 / 200 / 100 ppm. After incubation for 48 hours, the 12-well plate was taken out, and the cells in each well were gently scraped with a cell scraper and collected into a centrifuge tube. Centrifuge at 8000 rpm for 10 minutes, discard the supernatant, add 100 μL of 1M NaOH solution containing 10% DMSO, shake to resuspend the cells, and water bath at 80°C for 1 hour. Compare the color of the cells at the bottom of the centrifuge tube. The lighter the color, the better the whitening effect.

[0132] The positive control in the above sample is 200 ppm of arbutin.

[0133] Results Figure 8 The results showed that the whitening effect of the skin anti-redness and whitening carrier derived from plant seed meal (Example 1) prepared by combining ionic liquid and microemulsion technology was significantly better than that of the whitening composition prepared by alcohol extraction (Comparative Example 1).

[0134] In view of the problems of low plant extraction efficiency, poor solubility and low bioavailability, the present invention invents a skin redness-removing and whitening carrier derived from plant seed meal, which is dissolved in water to obtain a transparent solution, and can be applied to various dosage forms of cosmetic formulas, which is convenient for addition and storage. The present invention adopts a preparation method combining ionic liquid and microemulsion, and the prepared carrier can retain the effective ingredients of the active substance to a large extent. The carrier has the effect of removing spots and whitening, can greatly improve the solubility of the active substance in water, and at the same time improve its transdermal effect and improve its bioavailability.

[0135] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention can be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the present invention.

Claims

1. A method for preparing a skin redness-removing and whitening transporter derived from plant seed meal, characterized in that: include, Take the oil as phase A; The ionic liquid mixture of plant seed meal active ingredients is used as phase B; Mix the emulsifier and water as phase C; A, B and C were used as the three vertices of the pseudo-ternary phase diagram, and a pseudo-ternary phase diagram was drawn. The microemulsion was prepared according to the pseudo-ternary phase diagram method. Wherein, based on the total mass percentage of the raw materials, the phase A is 3-10%, the phase B is 10-20%, and the balance is the phase C to make up to 100%; The microemulsion preparation temperature is 60-70°C.

2. The preparation method according to claim 1, characterized in that: The plant seed meal active ingredients include one or more of grape seed meal extract, peony seed meal extract and tea seed meal extract.

3. The preparation method according to claim 1 or 2, characterized in that: The plant seed meal extract is a composition of grape seed meal, peony seed meal and tea seed meal, wherein the mass ratio of grape seed meal, peony seed meal and tea seed meal is 2:1:

1.

4. The preparation method according to claim 3, characterized in that: The preparation method of the plant seed meal extract comprises: Weigh the plant seed meal, crush it, and sieve it to obtain fine powder, use petroleum ether to defatting treatment, collect the solid residue, and place it in a ventilated place to allow the residual solvent to evaporate naturally, so as to obtain defatted plant seed meal powder; The defatted plant seed meal powder is mixed with a phosphate buffer solution with a pH of 8.0 at a mass ratio of 1:5, and 2% to 3% of papain is added, and the mixture is reacted at 40 to 45°C for 4 to 6 hours; After the reaction was completed, the reaction was inactivated under high pressure at 121°C for 20 minutes; The inactivated enzyme solution is filtered and concentrated, and the concentrated liquid is rotary dried to obtain a milky white powder, which is the plant seed meal extract.

5. The preparation method according to claim 1, characterized in that: The ionic liquid comprises lysophosphatidylcholine, glutamic acid, proline and deionized water; The molar ratio of lysophosphatidylcholine, glutamic acid and proline is 2:4:

3.

6. The preparation method according to claim 5, characterized in that: The preparation method of the ionic liquid comprises: Lysophosphatidylcholine, glutamic acid and proline were mixed, dissolved in water, stirred at 60°C to obtain a light yellow liquid, and stirred and balanced at room temperature for 24 hours. The mixture was vacuum dried to obtain a yellow viscous transparent ionic liquid after removing moisture.

7. The preparation method according to claim 6, characterized in that: The preparation method of the phase B comprises: The plant seed meal active ingredients were added into the ionic liquid at a mass ratio of 1:4, and stirred at room temperature until completely transparent to obtain phase B.

8. The preparation method according to claim 7, characterized in that: The oil includes one or more of polyperfluoromethyl isopropyl ether and cyclopentasiloxane, and the emulsifier includes one or more of PPG-6-decyltetradecyl alcohol polyether-30, cetearyl alcohol polyoxyethylene ether-6, cetearyl alcohol polyoxyethylene ether-25 and PEG-20 plant sterol.

9. The skin redness-removing and whitening delivery medium derived from plant seed meal obtained by the preparation method according to any one of claims 1 to 8.

10. Use of the plant seed meal-derived skin redness-removing and whitening carrier according to claim 9 in the preparation of redness-removing and whitening cosmetics, characterized in that: The redness-removing and whitening cosmetics are selected from one or more of facial cleansers, facial masks, lotions, emulsions, creams, and essences.

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