Externally applied traditional Chinese medicine ointment for rheumatism and preparation method of externally applied traditional Chinese medicine ointment

Abstract

The invention relates to a traditional Chinese medicine external application ointment for rheumatism and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine external application ointment. The externally-applied traditional Chinese medicine ointment is prepared from the following raw materials: 20 to 25 parts of rhizoma arisaematis powder, 20 to 25 parts of rhizoma pinelliae powder, 20 to 25 parts of rhizoma chuanxiong powder, 20 to 25 parts of radix aconiti kusnezoffii powder, 10 to 15 parts of menthol powder, 10 to 15 parts of camphor powder, 10 to 15 parts of pepper powder, 50 to 70 parts of rosin powder, 20 to 25 parts of honeysuckle flower extracting solution, 30 to 40 parts of beewax and 30 to 40 parts of peanut oil. A preparation process of the honeysuckle flower extracting solution comprises the following steps: (1) crushing honeysuckle flowers, putting the crushed honeysuckle flowers into a distillation kettle of a distillation device, and then adding water, so that the honeysuckle flower powder is fully soaked in the water; by adding anti-allergy components into the externally-applied traditional Chinese medicine ointment, the function of an immune system is adjusted, release of allergy media is reduced, irritation of the ointment to skin is reduced, allergic reactions are effectively reduced, and the safety of the ointment is effectively improved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine external application ointment, and particularly relates to a traditional Chinese medicine external application ointment for rheumatism and a preparation method thereof. Background Art

[0002] Rheumatism is a disease that affects bones, joints, muscles and their surrounding soft tissues such as bursae, tendons, fascia, blood vessels, nerves, etc. It can cause pain, swelling and movement disorders, and may even lead to damage to internal organs. Chinese herbal external application ointments are based on the principles of meridians in traditional Chinese medicine. They coordinate with each other and combine multiple drugs to exert their therapeutic effects. Chinese herbal external application ointments often contain drugs with strong odors, that is, aromatic drugs. These drugs penetrate through the skin and can produce anti-inflammatory, analgesic, and blood-activating effects, which help relieve symptoms such as pain and swelling of rheumatism.

[0003] However, in the process of these drugs penetrating through the skin, some patients may be allergic to the drugs due to their own reasons, or may have skin allergies due to environmental reasons, resulting in symptoms such as redness, swelling, and itching of the patient's skin due to drug irritation. Summary of the invention

[0004] The purpose of the present invention is to provide a Chinese medicine external application ointment for rheumatism and a preparation method thereof in order to solve the above problems.

[0005] The present invention achieves the above-mentioned purpose through the following technical solutions:

[0006] The invention provides a traditional Chinese medicine external application plaster for rheumatism. The preparation raw materials of the traditional Chinese medicine external application plaster include, by weight, 20-25 parts of arisaema powder, 20-25 parts of pinellia powder, 20-25 parts of chuanxiong powder, 20-25 parts of aconite powder, 10-15 parts of menthol powder, 10-15 parts of camphor powder, 10-15 parts of pepper powder, 50-70 parts of rosin powder, 20-25 parts of honeysuckle extract, 30-40 parts of beeswax and 30-40 parts of peanut oil.

[0007] As a further optimization scheme of the present invention, the preparation process of the honeysuckle extract is as follows: (i) crushing the honeysuckle and putting it into a distillation kettle of a distillation device, and then adding water to fully immerse the honeysuckle pollen in the water; (ii) heating the distillation kettle, and cooling the water vapor containing the honeysuckle pollen components through a condenser to obtain a honeysuckle pre-liquid; (iii) dripping a precipitant solution into the honeysuckle pre-liquid, adding 5-10 mL of the precipitant solution to every 100 mL of the extract; (iv) in the process of dripping the precipitant, continuously stirring the extract to allow chlorogenic acid to fully react with the precipitant, and in the process of dripping the precipitant solution, the reaction time of chlorogenic acid and the precipitant solution is 1 hour; (v) after the reaction is completed, separating the generated precipitate from the supernatant by a centrifugal filtration process, and cooling the supernatant to 5°C to obtain a honeysuckle extract.

[0008] As a further optimization scheme of the present invention, the raw materials for preparing the honeysuckle extract include: 5-10 parts of water, 40-50 parts of honeysuckle, and 20-30 parts of precipitant solution, and the precipitant solution is a calcium chloride solution.

[0009] As a further optimization scheme of the present invention, the raw materials for preparing the Chinese medicine external application ointment also include: 20-25 parts of soothing extract.

[0010] As a further optimization scheme of the present invention, the raw materials of the soothing extract include: 10-20 parts of coptis root powder, 10-20 parts of sophora flavescens powder, 10-20 parts of gentian powder, 10-20 parts of scutellaria powder, and 40-50 parts of gaseous carbon dioxide.

[0011] As a further optimization scheme of the present invention, the preparation process of the soothing extract is as follows: (i) placing coptis root powder, sophora flavescens powder, gentiana powder and scutellaria baicalensis powder into an extraction kettle of a supercritical extraction device, and injecting gaseous carbon dioxide, while adjusting the parameter temperature to 31.1°C and the critical pressure to 7.38MPa to make it in a supercritical state; (ii) the supercritical carbon dioxide fluid is fully in contact with the medicinal materials through the extraction kettle, and is extracted through a 1.5h extraction process, cooled to 5°C, to obtain a soothing extract.

[0012] The present invention also provides a method for preparing a Chinese medicine external application ointment for rheumatism, comprising the following steps:

[0013] S1, adjust the boiling temperature of rosin, beeswax and peanut oil to 80℃, and the boiling time is 30min;

[0014] S2, add arisaema powder, pinellia powder, chuanxiong powder, and aconite powder, stir and knead thoroughly for 15 minutes;

[0015] S3, then add honeysuckle extract and soothing extract and let stand for 7 days, then add menthol powder, camphor powder and pepper powder and fully blend to obtain a traditional Chinese medicine external application ointment.

[0016] The beneficial effects of the present invention are: by adding anti-allergic ingredients to the traditional Chinese medicine external application ointment, the function of the immune system is regulated, the release of allergic mediators is reduced, the irritation of the ointment to the skin is reduced, the occurrence of allergic reactions is effectively reduced, and the safety of the ointment is effectively improved. DETAILED DESCRIPTION

[0017] The present application is described in further detail below. It is necessary to point out that the following specific implementation methods are only used to further illustrate the present application and cannot be understood as limiting the scope of protection of the present application. Technicians in this field can make some non-essential improvements and adjustments to the present application based on the above application content.

[0018] 1. Materials

[0019] Unless otherwise specified, the methods used in the present invention are conventional methods known to those skilled in the art, and the reagents and other materials used are commercially available products unless otherwise specified.

[0020] The water used in the present invention is pure water.

[0021] Example 1

[0022] The raw materials for preparing the Chinese medicine external application ointment include: 20 parts of arisaema powder, 20 parts of pinellia powder, 20 parts of chuanxiong powder, 20 parts of aconite powder, 10 parts of menthol powder, 10 parts of camphor powder, 10 parts of pepper powder, 50 parts of rosin powder, 20 parts of honeysuckle extract, 30 parts of beeswax, 30 parts of peanut oil and 20 parts of soothing extract;

[0023] The raw materials of honeysuckle extract include: 5 parts of water, 40 parts of honeysuckle, and 20 parts of calcium chloride solution;

[0024] The soothing extract includes: 10 parts of coptis root powder, 10 parts of sophora flavescens powder, 10 parts of gentian powder, 10 parts of scutellaria powder, 40 parts of gaseous carbon dioxide;

[0025] The preparation process of honeysuckle extract is as follows: (i) crush the honeysuckle and put it into the distillation kettle of the distillation device, add 5L of water to fully soak the honeysuckle pollen in the water; (ii) heat the distillation kettle, and the water vapor containing the honeysuckle pollen components is cooled through a condenser to obtain a honeysuckle pre-liquid; (iii) add a precipitant solution dropwise to the honeysuckle pre-liquid, and add 8mL of the precipitant solution to every 100mL of the extract; (iv) in the process of adding the precipitant, continuously stir the extract to allow chlorogenic acid to fully react with the precipitant; (v) after the reaction is completed, separate the generated precipitate from the supernatant by a centrifugal filtration process, and cool the supernatant to 5°C to obtain a honeysuckle extract.

[0026] During the process of adding the precipitant solution dropwise, the reaction time of chlorogenic acid and the precipitant solution is 1 hour.

[0027] The preparation process of the soothing extract is as follows: (i) placing coptis root powder, sophora flavescens powder, gentian powder and scutellaria baicalensis powder into an extraction kettle of a supercritical extraction device, and injecting gaseous carbon dioxide, while adjusting the parameter temperature to 31.1°C and the critical pressure to 7.38MPa to make it in a supercritical state; (ii) the supercritical carbon dioxide fluid is fully in contact with the medicinal materials through the extraction kettle, and is extracted through a 1.5h extraction process, cooled to 5°C, to obtain a soothing extract.

[0028] First, boil rosin, beeswax, and peanut oil until the temperature reaches 80°C for 30 minutes, then add arisaema powder, pinellia powder, chuanxiong powder, and aconite powder, stir and rub for 15 minutes, then add honeysuckle extract and soothing extract and let stand for 7 days, finally add menthol powder, camphor powder, and pepper powder and fully blend to obtain a Chinese medicine external application ointment.

[0029] Example 2

[0030] The raw materials for preparing the Chinese medicine external application ointment include: 22 parts of arisaema powder, 22 parts of pinellia powder, 22 parts of chuanxiong powder, 22 parts of aconite powder, 12 parts of menthol powder, 12 parts of camphor powder, 12 parts of pepper powder, 60 parts of rosin powder, 22 parts of honeysuckle extract, 35 parts of beeswax, 35 parts of peanut oil and 22 parts of soothing extract;

[0031] The raw materials of honeysuckle extract include: 7.5 parts of water, 45 parts of honeysuckle, and 25 parts of calcium chloride solution;

[0032] The soothing extract includes: 15 parts of Coptis chinensis powder, 15 parts of Sophora flavescens powder, 15 parts of Gentiana scabra powder, 15 parts of Scutellaria baicalensis powder, and 45 parts of gaseous carbon dioxide;

[0033] The preparation process of honeysuckle extract is as follows: (i) crush the honeysuckle and put it into the distillation kettle of the distillation device, add 5L of water to fully soak the honeysuckle pollen in the water; (ii) heat the distillation kettle, and the water vapor containing the honeysuckle pollen components is cooled through a condenser to obtain a honeysuckle pre-liquid; (iii) add a precipitant solution dropwise to the honeysuckle pre-liquid, and add 8mL of the precipitant solution to every 100mL of the extract; (iv) in the process of adding the precipitant, continuously stir the extract to allow chlorogenic acid to fully react with the precipitant; (v) after the reaction is completed, separate the generated precipitate from the supernatant by a centrifugal filtration process, and cool the supernatant to 5°C to obtain a honeysuckle extract.

[0034] During the process of adding the precipitant solution dropwise, the reaction time of chlorogenic acid and the precipitant solution is 1 hour.

[0035] The preparation process of the soothing extract is as follows: (i) placing coptis root powder, sophora flavescens powder, gentian powder and scutellaria baicalensis powder into an extraction kettle of a supercritical extraction device, and injecting gaseous carbon dioxide, while adjusting the parameter temperature to 31.1°C and the critical pressure to 7.38MPa to make it in a supercritical state; (ii) the supercritical carbon dioxide fluid is fully in contact with the medicinal materials through the extraction kettle, and is extracted through a 1.5h extraction process, cooled to 5°C, to obtain a soothing extract.

[0036] First, boil rosin, beeswax, and peanut oil until the temperature reaches 80°C for 30 minutes, then add arisaema powder, pinellia powder, chuanxiong powder, and aconite powder, stir and rub for 15 minutes, then add honeysuckle extract and soothing extract and let stand for 7 days, finally add menthol powder, camphor powder, and pepper powder and fully blend to obtain a Chinese medicine external application ointment.

[0037] Example 3

[0038] The raw materials for preparing the Chinese medicine external application ointment include: 25 parts of arisaema powder, 25 parts of pinellia powder, 25 parts of chuanxiong powder, 25 parts of aconite powder, 15 parts of menthol powder, 15 parts of camphor powder, 15 parts of pepper powder, 70 parts of rosin powder, 25 parts of honeysuckle extract, 40 parts of beeswax and 40 parts of peanut oil, 25 parts of soothing extract;

[0039] The raw materials of honeysuckle extract include: 10 parts of water, 50 parts of honeysuckle, and 30 parts of calcium chloride solution;

[0040] The soothing extract includes: 20 parts of Coptis chinensis powder, 20 parts of Sophora flavescens powder, 20 parts of Gentiana scabra powder, 20 parts of Scutellaria baicalensis powder, and 50 parts of gaseous carbon dioxide;

[0041] The preparation process of honeysuckle extract is as follows: (i) crush the honeysuckle and put it into the distillation kettle of the distillation device, add 5L of water to fully soak the honeysuckle pollen in the water; (ii) heat the distillation kettle, and the water vapor containing the honeysuckle pollen components is cooled through a condenser to obtain a honeysuckle pre-liquid; (iii) add a precipitant solution dropwise to the honeysuckle pre-liquid, and add 8mL of the precipitant solution to every 100mL of the extract; (iv) in the process of adding the precipitant, continuously stir the extract to allow chlorogenic acid to fully react with the precipitant; (v) after the reaction is completed, separate the generated precipitate from the supernatant by a centrifugal filtration process, and cool the supernatant to 5°C to obtain a honeysuckle extract.

[0042] During the process of adding the precipitant solution dropwise, the reaction time of chlorogenic acid and the precipitant solution is 1 hour.

[0043] The preparation process of the soothing extract is as follows: (i) placing coptis root powder, sophora flavescens powder, gentian powder and scutellaria baicalensis powder into an extraction kettle of a supercritical extraction device, and injecting gaseous carbon dioxide, while adjusting the parameter temperature to 31.1°C and the critical pressure to 7.38MPa to make it in a supercritical state; (ii) the supercritical carbon dioxide fluid is fully in contact with the medicinal materials through the extraction kettle, and is extracted through a 1.5h extraction process, cooled to 5°C, to obtain a soothing extract.

[0044] First, boil rosin, beeswax, and peanut oil until the temperature reaches 80°C for 30 minutes, then add arisaema powder, pinellia powder, chuanxiong powder, and aconite powder, stir and rub for 15 minutes, then add honeysuckle extract and soothing extract and let stand for 7 days, finally add menthol powder, camphor powder, and pepper powder and fully blend to obtain a Chinese medicine external application ointment.

[0045] Comparative Example 1

[0046] The raw materials for preparing the Chinese medicine external application ointment include: 22 parts of arisaema powder, 22 parts of pinellia powder, 22 parts of chuanxiong powder, 22 parts of aconite powder, 12 parts of camphor powder, 12 parts of pepper powder, 60 parts of rosin powder, 32 parts of honeysuckle extract, 35 parts of beeswax, 35 parts of peanut oil and 22 parts of soothing extract;

[0047] The raw materials of honeysuckle extract include: 7.5 parts of water, 40 parts of honeysuckle, and 30 parts of calcium chloride solution;

[0048] The soothing extract includes: 15 parts of Coptis chinensis powder, 15 parts of Sophora flavescens powder, 15 parts of Gentiana scabra powder, 15 parts of Scutellaria baicalensis powder, and 45 parts of gaseous carbon dioxide;

[0049] The preparation process of honeysuckle extract is as follows: (i) crush the honeysuckle and put it into the distillation kettle of the distillation device, add 5L of water to fully soak the honeysuckle pollen in the water; (ii) heat the distillation kettle, and the water vapor containing the honeysuckle pollen components is cooled through a condenser to obtain a honeysuckle pre-liquid; (iii) add a precipitant solution dropwise to the honeysuckle pre-liquid, and add 8mL of the precipitant solution to every 100mL of the extract; (iv) in the process of adding the precipitant, continuously stir the extract to allow chlorogenic acid to fully react with the precipitant; (v) after the reaction is completed, separate the generated precipitate from the supernatant by a centrifugal filtration process, and cool the supernatant to 5°C to obtain a honeysuckle extract.

[0050] During the process of adding the precipitant solution dropwise, the reaction time of chlorogenic acid and the precipitant solution is 1 hour.

[0051] The preparation process of the soothing extract is as follows: (i) placing coptis root powder, sophora flavescens powder, gentian powder and scutellaria baicalensis powder into an extraction kettle of a supercritical extraction device, and injecting gaseous carbon dioxide, while adjusting the parameter temperature to 31.1°C and the critical pressure to 7.38MPa to make it in a supercritical state; (ii) the supercritical carbon dioxide fluid is fully in contact with the medicinal materials through the extraction kettle, and is extracted through a 1.5h extraction process, cooled to 5°C, to obtain a soothing extract.

[0052] First, boil rosin, beeswax, and peanut oil until the temperature reaches 80°C for 30 minutes, then add arisaema powder, pinellia powder, chuanxiong powder, and aconite powder, stir and rub for 15 minutes, then add honeysuckle extract and soothing extract and let stand for 7 days, finally add camphor powder and pepper powder and fully blend to obtain a Chinese medicine external application ointment.

[0053] Comparative Example 2

[0054] The raw materials for preparing the Chinese medicine external application ointment include: 22 parts of arisaema powder, 22 parts of pinellia powder, 22 parts of chuanxiong powder, 22 parts of aconite powder, 32 parts of menthol powder, 12 parts of camphor powder, 12 parts of pepper powder, 60 parts of rosin powder, 35 parts of beeswax, 35 parts of peanut oil and 22 parts of soothing extract;

[0055] The soothing extract includes: 15 parts of Coptis chinensis powder, 15 parts of Sophora flavescens powder, 15 parts of Gentiana scabra powder, 15 parts of Scutellaria baicalensis powder, and 45 parts of gaseous carbon dioxide;

[0056] The preparation process of the soothing extract is as follows: (i) placing coptis root powder, sophora flavescens powder, gentian powder and scutellaria baicalensis powder into an extraction kettle of a supercritical extraction device, and injecting gaseous carbon dioxide, while adjusting the parameter temperature to 31.1°C and the critical pressure to 7.38MPa to make it in a supercritical state; (ii) the supercritical carbon dioxide fluid is fully in contact with the medicinal materials through the extraction kettle, and is extracted through a 1.5h extraction process, cooled to 5°C, to obtain a soothing extract.

[0057] First, boil rosin, beeswax, and peanut oil until the temperature reaches 80°C for 30 minutes, then add arisaema powder, pinellia powder, chuanxiong powder, and aconite powder, stir and rub for 15 minutes, then add soothing extract and let stand for 7 days, finally add menthol powder, camphor powder, and pepper powder and fully blend to obtain a Chinese medicine external application ointment.

[0058] Comparative Example 3

[0059] The raw materials for preparing the Chinese medicine external application ointment include: 23 parts of arisaema powder, 23 parts of pinellia powder, 23 parts of chuanxiong powder, 23 parts of aconite powder, 14 parts of camphor powder, 14 parts of pepper powder, 62 parts of rosin powder, 37 parts of beeswax, 37 parts of peanut oil and 22 parts of soothing extract;

[0060] The soothing extract includes: 15 parts of Coptis chinensis powder, 15 parts of Sophora flavescens powder, 15 parts of Gentiana scabra powder, 15 parts of Scutellaria baicalensis powder, and 45 parts of gaseous carbon dioxide;

[0061] The preparation process of the soothing extract is as follows: (i) placing coptis root powder, sophora flavescens powder, gentian powder and scutellaria baicalensis powder into an extraction kettle of a supercritical extraction device, and injecting gaseous carbon dioxide, while adjusting the parameter temperature to 31.1°C and the critical pressure to 7.38MPa to make it in a supercritical state; (ii) the supercritical carbon dioxide fluid is fully in contact with the medicinal materials through the extraction kettle, and is extracted through a 1.5h extraction process, cooled to 5°C, to obtain a soothing extract.

[0062] First, boil rosin, beeswax, and peanut oil until the temperature reaches 80°C for 30 minutes, then add arisaema powder, pinellia powder, chuanxiong powder, and aconite powder, stir and rub for 15 minutes, then add honeysuckle extract and soothing extract and let stand for 7 days, finally add camphor powder and pepper powder and fully blend to obtain a Chinese medicine external application ointment.

[0063] Comparative Example 4

[0064] The raw materials for preparing the Chinese medicine external application ointment include: 22 parts of arisaema powder, 22 parts of pinellia powder, 22 parts of chuanxiong powder, 22 parts of aconite powder, 12 parts of menthol powder, 12 parts of camphor powder, 12 parts of pepper powder, 60 parts of rosin powder, 44 parts of honeysuckle extract, 35 parts of beeswax, and 35 parts of peanut oil;

[0065] The raw materials of honeysuckle extract include: 7.5 parts of water, 45 parts of honeysuckle, and 25 parts of calcium chloride solution;

[0066] The preparation process of honeysuckle extract is as follows: (i) crush the honeysuckle and put it into the distillation kettle of the distillation device, add 5L of water to fully soak the honeysuckle pollen in the water; (ii) heat the distillation kettle, and the water vapor containing the honeysuckle pollen components is cooled through a condenser to obtain a honeysuckle pre-liquid; (iii) add a precipitant solution dropwise to the honeysuckle pre-liquid, and add 5-10mL of the precipitant solution to every 100mL of the extract; (iv) in the process of adding the precipitant, continuously stir the extract to allow chlorogenic acid to fully react with the precipitant; (v) after the reaction is completed, separate the generated precipitate from the supernatant by a centrifugal filtration process, and cool the supernatant to 5°C to obtain a honeysuckle extract.

[0067] During the process of adding the precipitant solution dropwise, the reaction time of chlorogenic acid and the precipitant solution is 1 hour.

[0068] First, boil rosin, beeswax, and peanut oil until the temperature reaches 80°C for 30 minutes, then add arisaema powder, pinellia powder, chuanxiong powder, and aconite powder, stir and knead thoroughly for 15 minutes, then add honeysuckle extract and let stand for 7 days, finally add menthol powder, camphor powder, and pepper powder and fully blend to obtain a Chinese medicine external application ointment.

[0069] III. Methods

[0070] 3.1 Anti-allergy test

[0071] 1) Experimental subjects: 240 patients with rheumatic diseases.

[0072] 2) Experimental steps:

[0073] ①) applying the prepared external application ointment to the diseased parts of 240 patients, and the diseased parts of the patients were in the same position;

[0074] ②) 240 people were divided into six groups, with 40 people in each group, and were tested in six different environments: high temperature environment, normal temperature environment, low temperature environment, humid environment, relative humidity environment, and dry environment;

[0075] ③) Each person enters the testing environment at 8 o'clock in the morning. The testing time is 8 hours. During the testing period, the patient is not allowed to leave the testing environment.

[0076] ④) Everyone's meal time, portion, and ingredients are the same. In addition, the patient must be informed of the ingredients they will eat during the experiment before the experiment, and it must be ensured that the ingredients do not cause allergies in the patient;

[0077] The records are as follows Table 1:

[0078]

[0079] As can be seen from the above table, the number of people suffering from allergies in the six different environments are relatively large for the Chinese medicine external application ointments prepared in Example 1, Example 3 and Comparative Examples 1-3. It can be seen that the honeysuckle extract and menthol powder added in Example 2 have a good anti-allergic effect, and Example 2 is relatively stable in the six different environments.

[0080] 3.2 Soothing Experiment

[0081] 1) Experimental subjects: 240 patients with rheumatic diseases.

[0082] 2) Experimental steps:

[0083] ①) applying the prepared external application ointment to the diseased parts of 240 patients, and the diseased parts of the patients were in the same position;

[0084] ②) 240 people were divided into six groups, with 40 people in each group, and were tested in six different environments: high temperature environment, normal temperature environment, low temperature environment, humid environment, relative humidity environment, and dry environment;

[0085] ③) Each person enters the testing environment at 8 o'clock in the morning. The testing time is 8 hours. During the testing period, the patient is not allowed to leave the testing environment.

[0086] ④) Everyone's meal time, portion, and ingredients are the same. In addition, the patient must be informed of the ingredients they will eat during the experiment before the experiment, and it must be ensured that the ingredients do not cause allergies in the patient;

[0087] The records are as follows Table 1:

[0088]

[0089] As can be seen from the above table, the number of people suffering from allergies in the six different environments is relatively large for the prepared Chinese medicine external application ointments in Example 1, Example 3 and Comparative Example 4. It can be seen that the soothing extract added in Example 2 has a good soothing effect, and Example 2 is relatively stable in the six different environments. In addition, the soothing extract interacts with the honeysuckle extract and menthol powder to effectively improve the effect of the Chinese medicine external application ointment, inhibit allergic reactions, and reduce skin irritation, which helps to improve the safety of the ointment.

[0090] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A Chinese medicine external application ointment for rheumatism, characterized in that: The raw materials for preparing the traditional Chinese medicine external application ointment include, by weight: 20-25 parts of arisaema powder, 20-25 parts of pinellia powder, 20-25 parts of chuanxiong powder, 20-25 parts of aconite powder, 10-15 parts of menthol powder, 10-15 parts of camphor powder, 10-15 parts of pepper powder, 50-70 parts of rosin powder, 20-25 parts of honeysuckle extract, 30-40 parts of beeswax and 30-40 parts of peanut oil.

2. A Chinese medicine external application ointment for rheumatism according to claim 1, characterized in that: The preparation process of the honeysuckle extract is as follows: (i) crushing the honeysuckle and putting it into a distillation kettle of a distillation device, and then adding water to fully immerse the honeysuckle powder in the water; (ii) heating the distillation kettle, and cooling the water vapor containing the honeysuckle powder components through a condenser to obtain a honeysuckle pre-liquid; (iii) dripping a precipitant solution into the honeysuckle pre-liquid, adding 5-10 mL of the precipitant solution to every 100 mL of the extract; (iv) in the process of dripping the precipitant, continuously stirring the extract to allow chlorogenic acid to fully react with the precipitant, and in the process of dripping the precipitant solution, the reaction time of chlorogenic acid and the precipitant solution is 1 hour; (v) after the reaction is completed, separating the generated precipitate from the supernatant by a centrifugal filtration process, and cooling the supernatant to 5° C. to obtain a honeysuckle extract.

3. A Chinese medicine external application ointment for rheumatism according to claim 2, characterized in that: The raw materials for preparing the honeysuckle extract include: 5-10 parts of water, 40-50 parts of honeysuckle, and 20-30 parts of precipitant solution, wherein the precipitant solution is a calcium chloride solution.

4. A Chinese medicine external application ointment for rheumatism according to claim 2, characterized in that: The raw materials for preparing the traditional Chinese medicine external application ointment also include: 20-25 parts of soothing extract.

5. A Chinese medicine external application ointment for rheumatism according to claim 4, characterized in that: The soothing extract comprises raw materials of: 10-20 parts of coptis root powder, 10-20 parts of sophora flavescens powder, 10-20 parts of gentiana powder, 10-20 parts of scutellaria baicalensis powder, and 40-50 parts of gaseous carbon dioxide.

6. A Chinese medicine external application ointment for rheumatism according to claim 4, characterized in that: The preparation process of the soothing extract is as follows: (i) placing coptis root powder, sophora flavescens powder, gentian powder and scutellaria baicalensis powder into an extraction kettle of a supercritical extraction device, and injecting gaseous carbon dioxide, while adjusting the parameter temperature to 31.1°C and the critical pressure to 7.38MPa to make it in a supercritical state; (ii) the supercritical carbon dioxide fluid is fully in contact with the medicinal materials through the extraction kettle, and is extracted through a 1.5h extraction process, cooled to 5°C, to obtain a soothing extract.

7. A method for preparing the Chinese medicine external application ointment for rheumatism according to any one of claims 1 to 6, characterized in that: The following steps are involved: S1, boil rosin, beeswax and peanut oil until the temperature reaches 80°C and the boiling time is 30 minutes; S2, add arisaema powder, pinellia powder, chuanxiong powder, and aconite powder, stir and knead thoroughly for 15 minutes; S3, then add honeysuckle extract and soothing extract and let stand for 7 days, then add menthol powder, camphor powder and pepper powder and fully blend to obtain a traditional Chinese medicine external application ointment.

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