Medicine and instrument combined device for quantitative administration of temperature-sensitive gel preparation and administration method

Abstract

The invention provides a medicine and instrument combined device for quantitative administration of a temperature-sensitive gel preparation and an administration method. The device comprises a medicine cylinder, a base is arranged on the lower side of the medicine cylinder, the longitudinal center line of the medicine cylinder coincides with the longitudinal center line of the base, and the outline of the outer side face of the medicine cylinder is matched and consistent with the outline of the outer side face of the base; a medicine storage system is symmetrically arranged in the middle of the interior of the medicine cylinder, a cooling system is symmetrically arranged in the middle of the interior of the base and is in contact connection with the medicine storage system, and a temperature adjusting control system is arranged on the upper end face of the medicine cylinder and is in contact connection with the medicine storage system. Through the combined matching design of the cooling system, the temperature adjusting control system and the medicine storage system, the phase change temperature of the temperature-sensitive gel preparation is accurately adjusted, the fluidity of the temperature-sensitive gel preparation is guaranteed, convenience is provided for delivery of the temperature-sensitive gel preparation medicine, convenience is provided for storage and administration of the temperature-sensitive gel preparation medicine, the structure is compact and reasonable, the manufacturing process is simple, and the cost is low. The clinical use is convenient, and the administration experience feeling of a patient is enhanced.

Description

Technical Field

[0001] The present invention relates to the technical field of thermosensitive gel preparation administration, and in particular to a drug-machine combination device and an administration method for quantitative administration of thermosensitive gel preparations. Background Art

[0002] Thermosensitive gel refers to a preparation that, after being administered in a solution state, utilizes the polymer material to undergo a phase transition in response to the external temperature, transforming from a liquid state into a non-chemically cross-linked semisolid gel.

[0003] Thermosensitive gel materials can undergo certain phase changes as the ambient temperature changes, have a minimum critical dissolution temperature, and produce characteristics such as controlled release, sustained release, targeting, and reduced toxicity in the human body. They can be injected, implanted, and released for a long time, and are widely used in ocular, nasal, rectal, and injection administration.

[0004] Most thermosensitive gel preparations need to be stored at a certain low temperature to ensure their fluidity, so as to achieve more convenient drug delivery. However, since different thermosensitive gel preparations have different corresponding suitable storage temperatures, different storage temperatures need to be set for the storage of various thermosensitive gel preparations, which increases the storage cost. If a single storage temperature is set, it is usually set to the lower limit of the low temperature, and the patient's experience when taking the medicine is poor.

[0005] Therefore, the storage temperature needs to be adjusted according to the phase transition temperature required by the stored thermosensitive gel preparation. At present, the common practice is to control the ambient temperature of the thermosensitive gel preparation through external heating or cooling equipment, such as a heating plate, a cooler or a constant temperature water bath. However, this method has low accuracy in controlling and adjusting the temperature and is only suitable for small-scale applications in the laboratory, which is inconvenient for clinical use. Summary of the invention

[0006] In view of this, the first purpose of the present invention is to provide a drug-device combination device for quantitative administration of thermosensitive gel preparations. Through the combined matching design of a cooling system, a temperature control system and a drug storage system, the phase change temperature of the thermosensitive gel preparation can be accurately adjusted to ensure the fluidity of the thermosensitive gel preparation, so as to achieve more convenient delivery of thermosensitive gel preparation drugs, provide convenience for the storage and administration of thermosensitive gel preparation drugs, and make the device compact and reasonable in structure, simple in manufacturing process, and convenient for clinical use.

[0007] The second purpose of the present invention is to provide a method for quantitative administration of a thermosensitive gel preparation, which can arbitrarily adjust the temperature according to the phase change temperature of the thermosensitive gel preparation and achieve stable temperature control, thereby providing favorable temperature conditions for the storage of various thermosensitive gel preparations and improving the comfort of patients when taking medicine. When the phase change temperature needs to be lower, when the thermosensitive gel preparation drug is delivered to the device outlet, it is quickly heated to close to the body surface temperature, thereby enhancing the patient's medication experience.

[0008] In order to achieve the above-mentioned purpose of the present invention, the following technical solutions are particularly adopted: The present invention provides a drug-device combination device for quantitative administration of a temperature-sensitive gel preparation, comprising: a cartridge, a base is arranged on the lower side of the cartridge, the longitudinal center line of the cartridge coincides with the longitudinal center line of the base, and the outer side profile of the cartridge matches the outer side profile of the base; a drug storage system is symmetrically arranged in the center of the cartridge, a cooling system is symmetrically arranged in the center of the base, the cooling system is in contact with the drug storage system, and a temperature control system is arranged on the upper end surface of the cartridge, and the temperature control system is in contact with the drug storage system.

[0009] The drug storage system is installed symmetrically in the center of the cartridge, so that the thermosensitive gel preparation drugs are evenly contained in the cartridge, avoiding the impact of uneven filling on drug delivery. The cooling system is installed symmetrically in the center of the base, and achieves heat conduction through contact with the drug storage system, so that the periphery of the thermosensitive gel preparation drugs is subjected to a uniform heat transfer rate, ensuring the balance of the overall cooling of the drug storage system and the thermosensitive gel preparation drugs, and improving the cooling efficiency. The drug-device combination device has a smooth and simple shape. The longitudinal center line of the cartridge and the base is coaxially arranged, and the outer side surfaces are conformally matched and have consistent contours, which facilitates the clamping operation of the drug-device combination device and facilitates quantitative drug delivery.

[0010] The cooling system transfers heat and cools the drug storage system through heat conduction, provides storage temperature conditions for thermosensitive gel preparations, ensures the fluidity of thermosensitive gel preparations, and makes it easier to deliver thermosensitive gel preparations. For thermosensitive gel preparations with different phase change temperatures, the temperature control system heats up or cools down accordingly, facilitating the storage of a variety of thermosensitive gel preparations and improving the patient's experience when taking medicine.

[0011] Furthermore, the longitudinal center portion of the drug storage system is a thermosensitive gel drug storage area, and the outer side of the thermosensitive gel drug storage area is symmetrically wrapped and bonded with two or more heat transfer and cooling medium storage areas, and the interior of the heat transfer and cooling medium storage area is provided with a heat transfer and cooling storage medium, and the bottom of each of the heat transfer and cooling medium storage areas is soaked with the same volume of steel ice.

[0012] A heat transfer and cooling medium storage area is symmetrically arranged on the outside of the thermosensitive gel drug storage area, and the heat transfer and cooling medium storage area is soaked with the same volume of steel ice, which can evenly transfer heat and cool the periphery of the thermosensitive gel preparation drug, quickly reach the phase change temperature required by the thermosensitive gel preparation drug, and meet the storage conditions of the thermosensitive gel preparation drug.

[0013] The heat of the thermosensitive gel drug storage area is transferred to the steel ice through the heat transfer and cooling storage medium (such as water) in the heat transfer and cooling medium storage area wrapped on the outside. The structure of the steel ice is hollow and filled with special freezing liquid. The physical cooling principle is used to reduce the temperature of the heat transfer and cooling medium storage area and the thermosensitive gel drug storage area. The freezing effect lasts for a long time and can be recycled indefinitely.

[0014] Furthermore, the temperature control system includes two or more symmetrically arranged heating metal rods, the lower ends of the heating metal rods are inserted into the upper part of the heat transfer and cooling medium storage area, and are in contact with the heat transfer and cooling storage medium; the upper ends of the heating metal rods are connected to a control chip, and the control chip is embedded in the upper end surface of the cartridge.

[0015] When the required phase change temperature is higher, the heating metal rod feeds back the temperature detection to the control chip, and the control chip sends a heating instruction to the heating metal rod to heat the heat transfer and cooling storage medium (water) in the heat transfer and cooling medium storage area. After the heat transfer and cooling storage medium is heated to the specified temperature, it transfers the heat to the thermosensitive gel preparation drug in the thermosensitive gel drug storage area, causing the drug temperature to rise.

[0016] Furthermore, the cooling system includes a cooling water pipe, which is arranged through the transverse cross-section of the base, and the cooling water pipe extends from both sides of the base as a cooling inlet and a cooling outlet; at least one U-shaped cooling circulation pipe is symmetrically arranged relative to the transverse center of the cooling water pipe, and the closed section of the U of the cooling circulation pipe is tightly fitted with the outer surface of the cooling water pipe, and the open section of the U is tightly fitted with the heat transfer and cooling medium storage area. When the required phase change temperature is low, the heating metal rod stops heating, and cooling water is introduced into the cooling water pipe through the cooling inlet at the same time. After heat conduction between the cooling water and the cooling circulation pipe in the cooling water pipe, the cooling water is discharged from the cooling outlet. The cooling circulation pipe is symmetrically arranged relative to the cooling water pipe, so that the heat of the heat transfer and cooling medium storage area absorbed in the cooling circulation pipe is evenly released into the cooling water pipe, and the heat transfer and cooling storage medium (such as water) in the heat transfer and cooling medium storage area is quickly cooled. The opening section of the U-shaped structure is respectively connected to the heat transfer and cooling medium storage areas on both sides, and the heat between the heat transfer and cooling medium storage areas on both sides is circulated to achieve temperature balance of the heat transfer and cooling medium storage areas on both sides; after the heat transfer and cooling storage medium is cooled to the specified temperature, the thermosensitive gel preparation drugs in the thermosensitive gel drug storage area are cooled.

[0017] Optionally, the cooling inlet and the cooling outlet can be blocked or automatically controlled by means of a solenoid valve.

[0018] Furthermore, a cartridge grid is provided at the lower part of the heat transfer and cooling medium storage area, the steel ice is provided below the cartridge grid, the side length of the steel ice is less than the grid hole diameter of the cartridge grid, and the edge of the steel ice is a rounded structure.

[0019] The cartridge grille can both allow the heat transfer and cooling storage medium to pass through without affecting the immersion of the heat transfer and cooling storage medium in the steel ice, and block the steel ice to prevent the steel ice from being carried to the upper part of the heat transfer and cooling medium storage area due to the circulation of the heat transfer and cooling storage medium and touching the heating metal rod, thereby protecting the heating metal rod from being damaged by impact; the edge of the steel ice is designed to be chamfered to prevent the steel ice from scratching the inner wall of the heat transfer and cooling medium storage area and the cartridge grille.

[0020] Furthermore, an interface for connecting a needle or an atomizer head is provided at the upper center of the cartridge, the interface is connected to the thermosensitive gel drug storage area, a piston is provided on the inner lower side of the thermosensitive gel drug storage area, and the center lines of the interface, the thermosensitive gel drug storage area and the piston coincide.

[0021] The piston, the thermosensitive gel drug storage area, and the center of the interface from bottom to top are all aligned, so that the drug delivery process is evenly stressed and flows smoothly without retention, turbulence, etc. By pushing the piston downward or pulling it upward, the thermosensitive gel preparation drug is injected into or extracted from the thermosensitive gel drug storage area, which facilitates the delivery of the drug.

[0022] The material of the interface is a metal material with good thermal conductivity. Preferably, the material of the interface is copper.

[0023] Furthermore, a temperature-detecting metal rod is embedded in the upper end of the cartridge, an interface heating plate is provided on the interface, the temperature-detecting metal rod and the control chip are symmetrically arranged relative to the interface, the interface heating plate is connected to the temperature-detecting metal rod, and the temperature-detecting metal rod is connected to the control chip.

[0024] Specifically, the interface heating plate is connected to the temperature-detecting metal rod through a wire, and the temperature-detecting metal rod feeds back the detected temperature of the thermosensitive gel preparation drug to the control chip through a signal line. The temperature-detecting metal rod and the control chip are symmetrically arranged on both sides of the interface, so that the temperature-detecting metal rod and the control chip are at equal distances from the interface, so the lengths of the connected wires are also equal, which is conducive to the manufacture of the wires and makes the layout of the drug-device combination device compact and the structure simple; the control chip sends a command to the interface heating plate to heat the interface (preferably, the material of the interface is copper with good thermal conductivity) to the set temperature (preferably, the human body temperature of 37°C). When the thermosensitive gel preparation liquid passes through the interface, it is heated, which improves the comfort of the human body.

[0025] Furthermore, a heating metal rod temperature probe port is provided below the control chip, the heating metal rod temperature probe port is located on the inner upper side of the heat transfer and cooling medium storage area, the heating metal rod is connected to the heating metal rod temperature probe port, and the heating metal rod temperature probe port is connected to the control chip.

[0026] Specifically, the temperature detection port of the heating metal rod is connected to the heating metal rod through a wire, and the control chip sends a heating instruction to the heating metal rod through a signal line through the temperature detection feedback of the temperature detection port of the heating metal rod, thereby heating the heat transfer and cooling storage medium (such as water) in the heat transfer and cooling medium storage area.

[0027] Furthermore, a long strip of thermal conductive copper sheet laid in the up-and-down direction is provided at the center of the joining point between the heat transfer and cooling medium storage area and the temperature sensitive gel drug storage area.

[0028] After the heat transfer and cooling storage medium in the heat transfer and cooling medium storage area is heated or cooled to a specified temperature, heat is transferred to the thermosensitive gel preparation drug in the thermosensitive gel drug storage area through the long strip of thermal conductive copper sheet in large-area contact with the thermosensitive gel drug storage area. The thermal conductive copper sheet has an excellent thermal conductivity of 397W / m·K, so that the temperature of the thermosensitive gel drug storage area rises or falls rapidly.

[0029] The present invention also provides a method for quantitative administration of a thermosensitive gel preparation, which is applied to the drug-device combination device for quantitative administration of the thermosensitive gel preparation as described above, comprising: When the phase change temperature required for storing the thermosensitive gel preparation drug is high, the drug storage system feeds back the temperature detection to the temperature control system, and the temperature control system issues a heating instruction to heat the drug storage system, transfer the heating heat to the thermosensitive gel preparation drug, and raise the temperature of the thermosensitive gel preparation drug to the specified temperature; When the phase change temperature required for storing the thermosensitive gel preparation is low, the drug storage system feeds back the temperature detection to the temperature control system, and the temperature control system issues a stop heating instruction to stop heating the drug storage system; at the same time, the cooling system cools down the drug storage system, and transfers the cooling capacity to the thermosensitive gel preparation, so as to reduce the temperature of the thermosensitive gel preparation to the specified temperature; When the temperature of the thermosensitive gel reagent drug at the drug delivery site of the drug cartridge needs to be raised, the temperature of the thermosensitive gel reagent drug is fed back to the temperature control system, which issues a heating command to heat the drug delivery site of the drug cartridge, thereby raising the temperature of the thermosensitive gel reagent drug passing through the drug delivery site to the set temperature.

[0030] Compared with the prior art, the present invention has the following beneficial effects: The drug-mechanical combination device and drug administration method for quantitative administration of a thermosensitive gel preparation provided by the present invention accurately adjust the phase change temperature of the thermosensitive gel preparation through a combined matching design of a cooling system, a temperature control system and a drug storage system, thereby ensuring the fluidity of the thermosensitive gel preparation and achieving more convenient delivery of thermosensitive gel preparation drugs, providing convenience for the storage and administration of thermosensitive condensation preparation drugs, and the drug-mechanical combination device has a compact and reasonable structure, a simple manufacturing process, and is convenient for clinical use; the temperature can be adjusted at will according to the phase change temperature of the thermosensitive gel preparation, and stable temperature control can be achieved, providing favorable temperature conditions for the storage of various thermosensitive gel preparations, improving the patient's comfort when taking the medicine, and when the phase change temperature needs to be low, when the thermosensitive gel preparation drug is delivered to the device outlet, it is quickly heated to close to the body surface temperature, thereby enhancing the patient's drug administration experience. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Various other advantages and benefits will become apparent to those of ordinary skill in the art by reading the following detailed description of the preferred embodiment.The drawings are only for the purpose of illustrating the preferred embodiments and are not to be construed as limiting the invention.

[0032] In the attached picture: Figure 1 This is an overall structural appearance diagram of the drug-device combination device according to an embodiment of the present invention; Figure 2 This is an enlarged view of the upper part of the drug-device combination device according to an embodiment of the present invention; Figure 3 It is a side elevation view of the drug-device combination device according to an embodiment of the present invention; Figure 4 It is a side cross-sectional view of the drug-device combination device according to an embodiment of the present invention; Figure 5 It is a side elevation view of the base of the drug-device combination device according to an embodiment of the present invention; Figure 6 This is an internal structural diagram of the base of the drug-device combination device according to an embodiment of the present invention; Figure 7 This is a diagram showing the internal structure of a cartridge of a drug-device combination device according to an embodiment of the present invention; Figure 8 A structural view of a control system of an embodiment of the present invention located above the upper end surface of the cartridge; Fig. 9 This is a structural view of a control system according to an embodiment of the present invention, located below the upper end surface of the cartridge.

[0033] The symbols in the accompanying drawings are: 1. Cartridge, 101. Heat transfer and cooling medium storage area, 102. Cartridge grid, 103. Temperature sensitive gel drug storage area, 104. Temperature conductive copper sheet, 2. Base, 201. Cooling circulation pipe, 202. Base thread, 203. Cooling water pipeline, 3. Cooling inlet, 4. Heating metal rod, 401. Heating metal rod temperature detection port, 5. Interface, 501. Interface heating plate, 6. Control chip, 7. Steel ice, 8. Cooling outlet, 9. Temperature detection metal rod, 10. Piston. DETAILED DESCRIPTION

[0034] Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although exemplary embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided in order to enable a more thorough understanding of the present disclosure and to be able to fully convey the scope of the present disclosure to those skilled in the art. It should be noted that, in the absence of conflict, the embodiments of the present invention and the features described in the embodiments can be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0035] In the description of the present invention, it should be noted that the terms "inside", "outside", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0036] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the term "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be a connection between two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0037] Example The present invention provides a drug-device combination device for quantitative administration of a thermosensitive gel preparation, such as Figure 1 , 5 As shown, it includes a cartridge 1, the lower side of which is connected to the base 2 through a base thread 202, the longitudinal center line of the cartridge 1 coincides with the longitudinal center line of the base 2, and the outer side profile of the cartridge 1 matches the outer side profile of the base 2; a drug storage system is symmetrically arranged in the center of the cartridge 1, a cooling system is symmetrically arranged in the center of the base 2, the cooling system is in contact with and connected to the drug storage system, and a temperature control system is arranged on the upper end surface of the cartridge 1, the temperature control system is in contact with and connected to the drug storage system. The cooling system transfers heat and cools the drug storage system through heat conduction, provides storage temperature conditions for thermosensitive gel preparations, ensures the fluidity of thermosensitive gel preparations, and realizes more convenient delivery of thermosensitive gel preparations. For thermosensitive gel preparations with different phase change temperatures, the temperature control system performs corresponding heating or cooling, which facilitates the storage of a variety of thermosensitive gel preparations and improves the patient's experience when taking medicine. As shown Figure 3 , 4 As shown, the longitudinal center of the drug storage system is a temperature-sensitive gel drug storage area 103, and the outer side of the temperature-sensitive gel drug storage area 103 is symmetrically wrapped and attached to two heat transfer and cooling medium storage areas 101, such as Figure 7 As shown, a long strip of thermal conductive copper sheet 104 laid in the up-down direction is provided at the center of the joint of the heat transfer and cooling medium storage area 101 and the thermosensitive gel drug storage area 103. After the heat transfer and cooling storage medium in the heat transfer and cooling medium storage area 101 is heated or cooled to a specified temperature, heat is transferred to the thermosensitive gel preparation drug in the thermosensitive gel drug storage area 103 through the long strip of thermal conductive copper sheet 104 in contact with the thermosensitive gel drug storage area 103 over a large area, so that the temperature of the thermosensitive gel drug storage area rises or falls rapidly.

[0038] A heat transfer and cooling storage medium is arranged inside the heat transfer and cooling medium storage area 101, and the bottom of each heat transfer and cooling medium storage area 101 is soaked with the same volume of steel ice 7. The heat of the thermosensitive gel drug storage area 103 is transferred to the steel ice 7 through the heat transfer and cooling storage medium (water) in the heat transfer and cooling medium storage area 101 wrapped on the outside. The steel ice 7 uses the physical cooling principle to reduce the temperature of the heat transfer and cooling medium storage area 101 and the thermosensitive gel drug storage area 103, and the freezing effect lasts for a long time. A cartridge grille 102 is arranged at the lower part of the heat transfer and cooling medium storage area 101, and the steel ice 7 is arranged below the cartridge grille 102. The side length of the steel ice 7 is smaller than the grid hole diameter of the cartridge grille 102, and the edge of the steel ice 7 is designed as a rounded structure to prevent the steel ice 7 from scratching the inner wall of the heat transfer and cooling medium storage area and the cartridge grille. The cartridge grid 102 can not only pass the heat transfer and cooling storage medium without affecting the immersion of the heat transfer and cooling storage medium (water) into the steel ice 7, but also block the steel ice 7 to prevent the steel ice 7 from being carried to the upper part of the heat transfer and cooling medium storage area 101 due to the circulation of the heat transfer and cooling storage medium and touching the heating metal rod 4, thereby protecting the heating metal rod 4 from being damaged by impact.

[0039] like Figure 2 As shown, the temperature control system includes two symmetrically arranged heating metal rods 4. The lower ends of the heating metal rods 4 are inserted into the upper part of the heat transfer and cooling medium storage area 101 and are in contact with the heat transfer and cooling storage medium. The upper ends of the heating metal rods 4 are connected to the control chip 6, and the control chip 6 is embedded in the upper end surface of the cartridge 1. When the phase change temperature required by the thermosensitive gel preparation drug is high, the heating metal rods 4 will feed back the temperature detection to the control chip 6. The control chip 6 will issue a heating instruction to the heating metal rods 4 to heat the heat transfer and cooling storage medium (water) in the heat transfer and cooling medium storage area 101. After the water is heated to the specified temperature, it transfers the heat to the thermosensitive gel preparation drug in the thermosensitive gel drug storage area 103, so that the drug temperature rises. Fig. 9 As shown, a heating metal rod temperature probe port 401 is provided below the control chip 6, and the heating metal rod temperature probe port 401 is located on the upper side of the heat transfer and cooling medium storage area 101. The heating metal rod 4 is connected to the heating metal rod temperature probe port 401 through a wire, and the heating metal rod temperature probe port 401 is connected to the control chip 6 through a signal line. The control chip 6 sends a heating instruction to the heating metal rod 4 through the temperature detection feedback of the heating metal rod temperature probe port 401, and heats the heat transfer and cooling storage medium (water) in the heat transfer and cooling medium storage area 101.

[0040] like Figure 6As shown, the cooling system includes a cooling water pipe 203, which is arranged in the transverse section of the base 2, and the cooling water pipe 203 extends from both sides of the base 2 as a cooling inlet 3 and a cooling outlet 8; at least one U-shaped cooling circulation pipe 201 is symmetrically arranged relative to the transverse center of the cooling water pipe 203, and the U-shaped closed section of the cooling circulation pipe 201 is tightly fitted with the outer surface of the cooling water pipe 203, and the U-shaped open section is tightly fitted with the heat transfer and cooling medium storage area 101. When the phase change temperature required by the thermosensitive gel preparation drug is low, the heating metal rod 4 stops heating, and at the same time, the cooling water is passed into the cooling water pipe 203 through the cooling inlet 3. After the cooling water is heat-conducted with the cooling circulation pipe 201 in the cooling water pipe 203, it is discharged from the cooling outlet 8. After the cooling circulation pipe 201 cools the water of the heat transfer and cooling storage medium to a specified temperature, the thermosensitive gel preparation drug in the thermosensitive gel drug storage area 103 is cooled.

[0041] like Figure 1 , 4 As shown, an interface 5 for connecting a needle or an atomizing head is provided at the upper center of the cartridge 1, and the material of the interface 5 is copper. The interface 5 is connected to the thermosensitive gel drug storage area 103, and a piston 10 is provided on the inner lower side of the thermosensitive gel drug storage area 103, and the center lines of the interface 5, the thermosensitive gel drug storage area 103, and the piston 10 coincide. The piston 10, the thermosensitive gel drug storage area 103, and the interface 5 are all centrally arranged so that the force is evenly distributed during drug delivery, and the drug flows smoothly without retention, turbulence, and the like. By pushing the piston downward or pulling it upward, the thermosensitive gel preparation drug is injected into or extracted from the thermosensitive gel drug storage area, which facilitates the delivery of the drug. Figure 2 , 3 As shown, a temperature-detecting metal rod 9 is embedded in the upper end of the cartridge 1, and an interface heating plate 501 is provided on the interface 5. The temperature-detecting metal rod 9 and the control chip 6 are symmetrically arranged relative to the position of the interface 5, and the interface heating plate 501 is connected to the temperature-detecting metal rod 9 through a wire. Figure 8 As shown, the temperature detection metal rod 9 is connected to the control chip 6 through a signal line. The temperature detection metal rod 9 feeds back the detected temperature 9 of the thermosensitive gel preparation drug to the control chip 6; the control chip 6 sends a command to the interface heating plate 501 to heat, and the interface 5 is heated to 37°C, which improves the comfort of the human body.

[0042] The embodiment of the present invention further provides a method for quantitative administration of a thermosensitive gel preparation, which is applied to the drug-device combination device for quantitative administration of a thermosensitive gel preparation as described above, and specifically comprises: When the phase change temperature required for storing thermosensitive gel preparation drugs is high, the temperature detection feedback of the heat transfer and cooling medium storage area is obtained through the control chip, and a heating instruction is issued to the heating metal rod; the heat transfer and cooling storage medium in the heat transfer and cooling medium storage area is heated by the heating metal rod; after the heat transfer and cooling storage medium is heated to the specified temperature, the heat is transferred to the thermosensitive gel preparation drugs in the thermosensitive gel preparation drug storage area to increase the temperature of the thermosensitive gel preparation drugs; When the phase change temperature required for storing thermosensitive gel preparation drugs is low, the temperature detection feedback of the heat transfer and cooling medium storage area is obtained through the control chip, and a stop heating instruction is issued to the heating metal rod, so that the heating metal rod stops heating the heat transfer and cooling storage medium in the heat transfer and cooling medium storage area; at the same time, cooling water enters the cooling water pipeline through the cooling and cooling inlet, and the cooling water is discharged from the cooling and cooling outlet after heat conduction with the cooling circulation pipe in the cooling water pipeline, and the heat transfer and cooling storage medium in the heat transfer and cooling medium storage area is cooled through the cooling circulation pipe. After the heat transfer and cooling storage medium is cooled to the specified temperature, the thermosensitive gel preparation drugs in the thermosensitive gel drug storage area are cooled; When the temperature of the thermosensitive gel reagent drug flowing through the interface needs to be raised, the temperature of the thermosensitive gel reagent drug detected by the temperature detection metal rod is fed back to the control chip, and the control chip sends a heating instruction to the interface heating plate, which heats the interface through the interface heating plate to raise the temperature of the thermosensitive gel reagent drug passing through the interface to the set temperature.

[0043] So far, the technical solutions of the present invention have been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

[0044] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A drug-device combination device for quantitative administration of a thermosensitive gel preparation, characterized in that: include: A cartridge, wherein a base is arranged at the lower side of the cartridge, the longitudinal center line of the cartridge coincides with the longitudinal center line of the base, and the outer side profile of the cartridge matches the outer side profile of the base; a drug storage system is symmetrically arranged in the center of the cartridge, a cooling system is symmetrically arranged in the center of the base, the cooling system is in contact with and connected to the drug storage system, and a temperature control system is arranged on the upper end face of the cartridge, and the temperature control system is in contact with and connected to the drug storage system.

2. The drug-machine combination device for quantitative administration of a thermosensitive gel preparation according to claim 1, characterized in that: The longitudinal center of the drug storage system is a thermosensitive gel drug storage area, and the outer side of the thermosensitive gel drug storage area is symmetrically wrapped and bonded with two or more heat transfer and cooling medium storage areas, and the interior of the heat transfer and cooling medium storage area is provided with a heat transfer and cooling storage medium, and the bottom of each of the heat transfer and cooling medium storage areas is soaked with the same volume of steel ice.

3. The drug-machine combination device for quantitative administration of a thermosensitive gel preparation according to claim 2, characterized in that: The temperature control system includes two or more symmetrically arranged heating metal rods, the lower ends of the heating metal rods are inserted into the upper part of the heat transfer and cooling medium storage area and are in contact with the heat transfer and cooling storage medium; the upper ends of the heating metal rods are connected to a control chip, and the control chip is embedded in the upper end surface of the cartridge.

4. The drug-machine combination device for quantitative administration of a thermosensitive gel preparation according to claim 2, characterized in that: The cooling system includes a cooling water pipeline, which is arranged through the transverse cross-section of the base. The cooling water pipeline extends from both sides of the base as a cooling inlet and a cooling outlet. At least one U-shaped cooling circulation pipe is symmetrically arranged relative to the transverse center of the cooling water pipeline. The closed section of the U of the cooling circulation pipe fits tightly with the outer surface of the cooling water pipeline, and the open section of the U fits tightly with the heat transfer and cooling medium storage area.

5. The drug-machine combination device for quantitative administration of a thermosensitive gel preparation according to claim 2, characterized in that: A cartridge grid is arranged at the lower part of the heat transfer and cooling medium storage area, the steel ice is arranged below the cartridge grid, the side length of the steel ice is less than the grid hole diameter of the cartridge grid, and the edge of the steel ice is a rounded structure.

6. The drug-machine combination device for quantitative administration of a thermosensitive gel preparation according to claim 3, characterized in that: An interface for connecting a needle or an atomizer head is provided at the upper center of the cartridge, the interface is connected to the thermosensitive gel drug storage area, a piston is provided on the lower inner side of the thermosensitive gel drug storage area, and the center lines of the interface, the thermosensitive gel drug storage area, and the piston coincide.

7. The drug-machine combination device for quantitative administration of a thermosensitive gel preparation according to claim 6, characterized in that: A temperature-detecting metal rod is embedded in the upper end of the cartridge, an interface heating plate is provided on the interface, the temperature-detecting metal rod and the control chip are symmetrically arranged relative to the interface, the interface heating plate is connected to the temperature-detecting metal rod, and the temperature-detecting metal rod is connected to the control chip.

8. The drug-machine combination device for quantitative administration of a thermosensitive gel preparation according to claim 3, characterized in that: A heating metal rod temperature probe port is provided below the control chip, and the heating metal rod temperature probe port is located on the inner upper side of the heat transfer and cooling medium storage area. The heating metal rod is connected to the heating metal rod temperature probe port, and the heating metal rod temperature probe port is connected to the control chip.

9. The drug-machine combination device for quantitative administration of a thermosensitive gel preparation according to claim 3 or 4, characterized in that: A long strip of thermal conductive copper sheet laid in the up-and-down direction is arranged at the center of the joining point between the heat transfer and cooling medium storage area and the temperature sensitive gel drug storage area.

10. A method for quantitative administration of a thermosensitive gel preparation, applied to the drug-machine combination device for quantitative administration of a thermosensitive gel preparation as claimed in any one of claims 1 to 9, characterized in that: include: When the phase change temperature required for storing the thermosensitive gel preparation drug is high, the drug storage system feeds back the temperature detection to the temperature control system, and the temperature control system issues a heating instruction to heat the drug storage system, transfer the heating heat to the thermosensitive gel preparation drug, and raise the temperature of the thermosensitive gel preparation drug to the specified temperature; When the phase change temperature required for storing the thermosensitive gel preparation is low, the drug storage system feeds back the temperature detection to the temperature control system, and the temperature control system issues a stop heating instruction to stop heating the drug storage system; at the same time, the cooling system cools down the drug storage system, and transfers the cooling capacity to the thermosensitive gel preparation, so as to reduce the temperature of the thermosensitive gel preparation to the specified temperature; When the temperature of the thermosensitive gel reagent drug at the drug delivery site of the drug cartridge needs to be raised, the temperature of the thermosensitive gel reagent drug is fed back to the temperature control system, which issues a heating command to heat the drug delivery site of the drug cartridge, thereby raising the temperature of the thermosensitive gel reagent drug passing through the drug delivery site to the set temperature.

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