Microbial separation device for biological drug detection

Abstract

The invention discloses a microbial separation device for biological drug detection, and belongs to the technical field of microbial separation devices. The temperature adjusting mechanism comprises a panel arranged on the inner wall of the box body, an annular clamping groove is formed in the panel, a bimetallic strip is installed on the panel in a clamping and fixing mode, an annularly-arranged passive layer is connected to the edge of the outer wall of the bimetallic strip, an active layer is connected to the passive layer in an integrally-formed mode, and the active layer is connected to the inner wall of the box body in an integrally-formed mode. A movable opening formed in the panel is formed in one end of the active layer, a pull rope is connected to the active layer through a lifting rod, and a guide groove is connected to the outer wall of the lifting rod in the height direction of the sleeve. The technical problems that an existing culture environment cannot achieve automatic intelligent adjustment on temperature and water supply, people need to continuously observe and adjust, manual operation is inconvenient, the working efficiency is reduced, and effective separation between microorganisms is not facilitated are solved.

Description

Technical Field

[0001] The present invention belongs to the technical field of microbial separation equipment, and in particular relates to a microbial separation device for biological drug detection. Background Art

[0002] Microorganisms are a general term for a class of organisms, including bacteria, viruses, fungi, actinomycetes, rickettsia, mycoplasma, chlamydia and spirochetes. These microorganisms are widely distributed in nature. Most of them can only be seen with a microscope, and a few can be seen with the naked eye, such as mushrooms and other fungi.

[0003] When testing drugs, microorganisms need to be separated from the organisms inside them. Existing methods for separating microorganisms include dilution plate method, streak method, and plate coating method. For example, the enrichment culture method creates specific conditions for the growth of the desired microorganisms, making them far superior to other microorganisms in terms of growth capacity. If some obligate parasites are to be separated, the sample must be inoculated into the corresponding sensitive host cell population, and pure parasites can be obtained by repeated transplantation.

[0004] During the cultivation process, the enrichment culture method has high requirements for the temperature and the water content on the culture dish. The temperature and water content need to be kept within a certain range, and the concentration of airborne particulates in the culture environment is controlled within a certain range to ensure the dust-free effect of the culture environment. However, the existing culture environment cannot achieve automatic intelligent adjustment for the temperature and water supply, and requires personnel to constantly observe and adjust. Manual operation is inconvenient, which also reduces work efficiency and is not conducive to the effective separation of microorganisms. Summary of the invention

[0005] The purpose of the present invention is to provide a microbial separation device for biological drug detection to solve the technical problem that the existing culture environment cannot realize automatic intelligent adjustment of temperature and water supply, requires personnel to constantly observe and adjust, is inconvenient for manual operation, reduces work efficiency, and is not conducive to the effective separation of microorganisms.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions: A microbial separation device for biopharmaceutical testing, comprising: Box; A temperature regulating mechanism, the temperature regulating mechanism comprising a panel placed on the inner wall of the box, the panel being provided with an annular slot and being provided with a bimetallic strip by means of a snap-fitting fixation, a passive layer arranged in an annular manner being connected to the edge of the outer wall of the bimetallic strip, an active layer being integrally connected to the passive layer, a movable opening placed on the panel being provided at one end of the active layer, and a pull rope being connected to the active layer via a lifting rod, a guide groove being connected to the outer wall of the lifting rod along the height direction of the sleeve, and the extension ends on both sides of the sleeve being fixed to the bottom of the panel; One end of the pull rope is connected to the lifting ring on the first movable plate through the guide wheel, the top of the first movable plate is electrically connected to a double-axis motor fixed on the support plate through a power supply component, and the support plate and the inner wall of the box are fixedly connected through a crossbeam; The power supply assembly includes a first spring fixed between the two sides of the top of the first movable plate and the shell, and a plug rod fixed to the first movable plate is provided between the first springs. The top of the plug rod passes through the shell and extends to the gap between the battery packs, and the top of the plug rod is set in a cone shape. One end of the dual-axis motor is connected to a movable shaft through a reciprocating screw, and the other end extends to the cam. A scraper placed at the ventilation hole is installed on the movable shaft.

[0007] Furthermore, the reciprocating screw is spirally driven with a slider fixed on the cleaning brush, and the cleaning brush is in contact with the ventilation duct along the length direction of the box body. The ventilation duct is arranged in a Y shape, and the bottom of the ventilation duct extends into the collection box. The edge of the outer wall of the scraper is close to the reciprocating screw and a filter is detachably installed on the ventilation hole, and the scraper is connected to the movable shaft by plugging and fixing.

[0008] Furthermore, the ventilation duct is fixedly connected to the inner wall of the box by means of a fastening bolt, the collection box is of a push-pull movable design, and a handle is integrally formed and connected to the outer wall of the collection box.

[0009] Furthermore, it also includes a water supply mechanism, which includes a movable plate that abuts against the top of the cam, one end of the movable plate passes through the box body and extends to the second movable plate, and the movable plate is provided with a strip groove along the height direction of the inner wall of the box body, the top of the second movable plate and the fixed plate installed on the inner wall of the box body are connected by a second spring, and the bottom of the second movable plate is connected to a retaining ring placed on the inner wall of the conduit through a bracket.

[0010] Furthermore, one end of the conduit is connected to a water storage tank disposed inside the box body through a U-shaped tube, and the other end is connected to a water outlet through a multi-way tube.

[0011] Furthermore, a culture dish placed inside the box is provided below the water outlet, the culture dishes are connected by columns, and the bottom of the column passes through the culture dish and extends to the bottom end of the inner wall of the box.

[0012] Furthermore, cushion blocks are installed around the bottom end of the box body, and elastic plates are connected to the cushion blocks by means of adhesive installation.

[0013] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are: (1) A temperature regulating mechanism is provided. When the ambient temperature in the culture dish rises, the active layer is deformed and bent by the heat, and drives the lifting rod to pass through the sleeve and move upward synchronously with the pull rope. The pull rope transmits the pulling force to the first movable plate through the transmission action of the guide wheel and moves it downward. In this way, the tapered portion on the plug rod is separated from the battery pack, so that the battery packs can be connected and the dual-axis motor can be powered normally and perform corresponding heat dissipation. When the temperature in the box cools down, the active layer can return the lifting rod to its original position, and under the action of the elastic restoring force of the first spring, the plug rod can be inserted between the battery packs for isolation, so that it can automatically adjust to different ambient temperatures adaptively without starting the cooler, effectively saving resources and being beneficial to environmental protection. In addition, the ambient temperature outside the culture dish can be controlled within a suitable range, so that the microorganisms can grow well.

[0014] (2) A heat dissipation mechanism is provided. When the dual-axis motor is started, it can drive the reciprocating screw and the movable shaft to rotate synchronously. During the rotation of the movable shaft, the scraper on the filter screen can be driven to rotate. In this way, the impurities adsorbed on the filter screen can be removed while the heat is dissipated, thereby avoiding affecting the filtering effect of the filter screen and improving the stability of the device. In addition, during long-term use, dust and impurities in the air will adhere to the inner wall of the ventilation duct. Since the ventilation duct is set in a Y shape and with the help of the spiral transmission action of the reciprocating screw, the dust particles can be swept into the collection box, thereby playing an automatic cleaning role. Moreover, the collection box is a push-pull movable design, which is conducive to the cleaning work of the personnel and improves the work efficiency. At the same time, it effectively ensures the dust-free effect of the culture environment and can control the concentration of air suspended particles in the culture environment within a certain range.

[0015] (3) A water supply mechanism is provided. When the temperature rises, it means that the water on the culture dish evaporates to a certain extent. At this time, after the dual-axis motor is started, it can drive the cam to rotate. In conjunction with the second movable plate on the second spring, the rotational motion of the cam can be converted into the up and down reciprocating motion of the second movable plate. At the same time, when the second movable plate is moving, the retaining ring can be used to perform intermittent conveying of the water in the conduit to prevent excessive discharge due to excessive water flow. At the same time, the U-shaped pipe on the water storage tank can play the role of automatic water replenishment by using the principle of communicating vessels. It has a high degree of intelligence and ensures the stable operation of the device.

[0016] (4) A supporting mechanism is provided. A culture dish connected to a column is provided inside the box. Multiple culture dishes are provided in the height direction of the column. On the one hand, space resources can be effectively utilized. On the other hand, the supporting mechanism can be matched with the water supply mechanism, thereby realizing water supply operations at multiple water outlets through multi-way pipes, thereby ensuring normal water supply operations on the culture dishes. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0018] Figure 1 It is a schematic structural diagram of a microorganism separation device for biological drug detection according to the present invention; Figure 2 It is a schematic diagram of the interior of the box of the present invention; Figure 3 It is a front view of the interior of the box of the present invention; Figure 4 The present invention Figure 1 A magnified image of point A; Figure 5 The present invention Figure 2 The enlarged view of point B; Figure 6 It is a connection diagram of the battery pack of the plug rod of the present invention; Figure 7 It is a connection schematic diagram of the reciprocating screw of the present invention; Figure 8 The present invention Figure 2 Enlarged view of point C; Fig. 9 It is a structural schematic diagram of the box body of the present invention.

[0019] Figure numerals: 1. box body; 2. temperature regulating mechanism; 3. bimetallic strip; 4. passive layer; 5. active layer; 6. lifting rod; 7. pull rope; 8. sleeve; 9. guide wheel; 10. first movable plate; 11. lifting ring; 12. power supply assembly; 13. dual-axis motor; 14. first spring; 15. plug rod; 16. battery pack; 17. reciprocating screw; 18. movable shaft; 19. cam; 20. scraper; 21. cleaning brush; 22. slider; 23. ventilation duct; 24. collecting box; 25. filter; 26. water supply mechanism; 27. movable plate; 28. second movable plate; 29. ​​fixed plate; 30. second spring; 31. conduit; 32. retaining ring; 33. U-shaped tube; 34. water storage tank; 35. culture dish. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] Reference Manual Attached Figure 1 and Figure 2 As shown, a microorganism separation device for biological drug detection comprises: a box body 1; a temperature regulating mechanism 2, the temperature regulating mechanism 2 comprises a panel placed on the inner wall of the box body 1, an annular slot is provided on the panel and a bimetallic strip 3 is installed by a snap-fitting manner, a passive layer 4 arranged in an annular manner is connected to the edge of the outer wall of the bimetallic strip 3, an active layer 5 is integrally formed and connected to the passive layer 4, one end of the active layer 5 is provided with a movable opening placed on the panel, and a pull rope 7 is connected to the active layer 5 through a lifting rod 6, the outer wall of the lifting rod 6 is connected with a guide groove along the height direction of a sleeve 8, and the extension ends on both sides of the sleeve 8 are fixed to the bottom of the panel; Among them, one end of the pull rope 7 is pulled and connected to the lifting ring 11 on the first movable plate 10 through the guide wheel 9. The top of the first movable plate 10 is electrically connected to the dual-axis motor 13 fixed on the support plate through the power supply component 12. The support plate and the inner wall of the box body 1 are fixedly connected by a cross beam.

[0022] Specifically, the temperature regulating mechanism 2 utilizes the bimetallic strip 3. Since the thermal expansion coefficients of the component layers are different, when the temperature changes, the deformation of the active layer 5 is greater than the deformation of the passive layer 4, so that the bimetallic strip 3 as a whole will bend toward the passive layer 4. The curvature of the composite material changes and thus produces deformation, which can drive the lifting rod 6 to move up and down during the change process. At the same time, the setting of the sleeve 8 can prevent the lifting rod 6 from deviating from its position during the movement.

[0023] A temperature regulating mechanism 2 is provided. When the ambient temperature in the culture dish 35 rises, the active layer 5 is deformed and bent by the heat, and drives the lifting rod 6 to pass through the sleeve 8 and move upward synchronously with the pull rope 7. The pull rope 7 transmits the pulling force to the first movable plate 10 through the transmission action of the guide wheel 9 and moves it downward, so that the tapered portion on the insertion rod 15 will be separated from the battery pack 16, so that the battery packs 16 can be connected and the dual-axis motor 13 can be powered normally and the corresponding heat dissipation work can be performed. When the temperature in the box body 1 cools down, the active layer 5 can return the lifting rod 6 to its original position, and under the action of the elastic restoring force of the first spring 14, the insertion rod 15 can be inserted between the battery packs 16 for isolation, so that different ambient temperatures can be adaptively and automatically adjusted without starting the cooler, which effectively saves resources and is beneficial to environmental protection. Moreover, the ambient temperature outside the culture dish 35 can be controlled within a suitable range, so that the microorganisms can grow well.

[0024] In addition, the guide wheel 9 inside the box body 1 can play a corrective role on the pull rope 7 during the movement, and can effectively transmit the power of the pull rope 7 to the first movable plate 10.

[0025] A heat dissipation mechanism is provided. When the dual-axis motor 13 is started, it can drive the reciprocating screw 17 and the movable shaft 18 to rotate synchronously. During the rotation process, the movable shaft 18 can drive the scraper 20 on the filter 25 to rotate, so that the impurities adsorbed on the filter 25 can be removed while the heat is dissipated, so as to avoid affecting the filtering effect of the filter 25 and improve the stability of the device. In addition, during long-term use, dust and impurities in the air will adhere to the inner wall of the ventilation duct 23. Since the ventilation duct 23 is Y-shaped, and with the help of the spiral transmission action of the reciprocating screw 17, the dust particles can be swept into the collection box 24, thereby playing an automatic cleaning role. Moreover, the collection box 24 is a push-pull movable design, which is conducive to the cleaning work of the personnel and improves the work efficiency. At the same time, it effectively ensures the dust-free effect of the culture environment and can control the concentration of air suspended particles in the culture environment within a certain range.

[0026] refer to Figure 2 , Figure 3 and Figure 6 The power supply assembly 12 includes a first spring 14 fixed between the two sides of the top of the first movable plate 10 and the shell, and a plug rod 15 fixed to the first movable plate 10 is provided between the first springs 14. The top of the plug rod 15 passes through the shell and extends to the gap between the battery packs 16, and the top of the plug rod 15 is set in a cone shape. One end of the dual-axis motor 13 is connected to a movable shaft 18 through a reciprocating screw 17, and the other end extends to a cam 19. A scraper 20 placed at the ventilation hole is installed on the movable shaft 18.

[0027] The power supply assembly 12 can realize power-off and power-on operation by separating and closing the battery packs 16 , so that the dual-axis motor 13 can be started or stopped accordingly.

[0028] refer to Figure 2 , Figure 3 , Figure 4 , Figure 5 and Figure 7 A slider 22 fixed on a cleaning brush 21 is spirally driven on the reciprocating screw 17. The cleaning brush 21 contacts and fits on a ventilation duct 23 along the length direction of the box body 1. The ventilation duct 23 is arranged in a Y shape, and the bottom of the ventilation duct 23 extends to the collecting box 24. A filter screen 25 placed at the ventilation hole is detachably installed on the outer wall edge of the scraper 20 near the reciprocating screw 17, and the scraper 20 is connected to the movable shaft 18 by plugging and fixing.

[0029] The ventilation duct 23 is fixedly connected to the inner wall of the box body 1 by means of a fastening bolt, and the collection box 24 is designed to be push-pull movable, and a handle is integrally formed on the outer wall of the collection box 24.

[0030] After the dual-axis motor 13 is started, it can drive the reciprocating screw 17 and the scraper 20 on the movable shaft 18 to rotate simultaneously. With the help of the spiral transmission action, the cleaning brush 21 can clean the attached particulate impurities into the collection box 24 during the movement. In this way, the filter 25 can start the secondary cleaning in conjunction with the cleaning brush 21 during the initial cleaning work, effectively ensuring the dust-free effect inside the box 1.

[0031] refer to Figure 2 , Figure 8 and Fig. 9 , and also includes a water supply mechanism 26, which includes a movable plate 27 that contacts and fits with the top of the cam 19, one end of the movable plate 27 passes through the box body and extends to the second movable plate 28, and the movable plate 27 is provided with a strip groove along the height direction of the inner wall of the box body, the top of the second movable plate 28 and a fixed plate 29 installed on the inner wall of the box body are connected by a second spring 30, and the bottom of the second movable plate 28 is connected to a retaining ring 32 placed on the inner wall of the conduit 31 through a bracket.

[0032] A supporting mechanism is provided, and a culture dish 35 connected to a column is provided inside the box body 1. A plurality of culture dishes 35 are provided in the height direction of the column. On the one hand, space resources can be effectively utilized, and on the other hand, they can be matched with the water supply mechanism 26, so that water supply operations at multiple water outlets can be realized through multi-way pipes, thereby ensuring normal water supply operations on the culture dishes 35.

[0033] One end of the conduit 31 is connected to a water storage tank 34 placed inside the box body through a U-shaped tube 33, and the other end is connected to a water outlet through a multi-way tube. A culture dish 35 placed inside the box body 1 is provided below the water outlet. The culture dishes 35 are connected by columns, and the bottom of the columns penetrates the culture dishes 35 and extends to the bottom end of the inner wall of the box body 1. Pads are installed around the bottom end of the box body 1, and elastic plates are connected to the pads by adhesive mounting.

[0034] A water supply mechanism 26 is provided. When the temperature rises, it means that the water on the culture dish 35 evaporates to a certain extent. At this time, after the dual-axis motor 13 is started, it can drive the cam 19 to rotate. In conjunction with the second movable plate 28 on the second spring 30, the rotational motion of the cam 19 can be converted into the up and down reciprocating motion of the second movable plate 28. At the same time, when the second movable plate 28 is moving, the retaining ring 32 can be used to perform interval conveying work on the water in the conduit 31 to prevent excessive discharge due to excessive water flow. At the same time, the U-shaped pipe 33 on the water storage tank 34 can play a role of automatic water replenishment by using the principle of communicating vessels. It has a high degree of intelligence and ensures the stable operation of the device.

[0035] The above are only preferred specific implementation modes of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical solutions and inventive concepts of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

[0036] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to only specific implementation methods. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A microbial separation device for biopharmaceutical testing, characterized in that: include: Box (1); A temperature regulating mechanism (2), the temperature regulating mechanism (2) comprising a panel placed on the inner wall of a box body (1), the panel being provided with an annular slot and having a bimetallic strip (3) mounted thereon by means of a snap-fitting manner, the outer wall edge of the bimetallic strip (3) being connected to an annularly arranged passive layer (4), the passive layer (4) being integrally formed with an active layer (5), one end of the active layer (5) being provided with a movable opening placed on the panel, and the active layer (5) being connected to a pull rope (7) via a lifting rod (6), the outer wall of the lifting rod (6) being connected to a guide groove along the height direction of a sleeve (8), and both side extension ends of the sleeve (8) being fixed to the bottom of the panel; One end of the pull rope (7) is pulled and connected to a lifting ring (11) on the first movable plate (10) through a guide wheel (9); the top of the first movable plate (10) is electrically connected to a dual-axis motor (13) fixed on a support plate through a power supply component (12); and the support plate and the inner wall of the box body (1) are fixedly connected through a crossbeam; The power supply assembly (12) comprises a first spring (14) fixed between the two sides of the top of the first movable plate (10) and the housing, a plug rod (15) fixed to the first movable plate (10) is provided between the first springs (14), the top of the plug rod (15) passes through the housing and extends to the gap between the battery packs (16), and the top of the plug rod (15) is arranged in a conical shape, one end of the dual-axis motor (13) is connected to a movable shaft (18) via a reciprocating screw (17), and the other end extends to a cam (19), and a scraper (20) placed at the ventilation hole is installed on the movable shaft (18).

2. A microbial separation device for biopharmaceutical detection according to claim 1, characterized in that: The reciprocating screw (17) is spirally driven with a slider (22) fixed on the cleaning brush (21); the cleaning brush (21) is in contact with the ventilation duct (23) along the length direction of the box (1); the ventilation duct (23) is arranged in a Y shape, and the bottom of the ventilation duct (23) extends into the collection box (24); a filter screen (25) disposed at the ventilation hole is detachably mounted on the outer wall edge of the scraper (20) near the reciprocating screw (17), and the scraper (20) is connected to the movable shaft (18) by plugging and fixing.

3. A microorganism separation device for biopharmaceutical detection according to claim 2, characterized in that: The ventilation duct (23) is fixedly connected to the inner wall of the box body (1) by means of a fastening bolt, and the collection box (24) is of a push-pull movable design, and a handle is integrally formed and connected to the outer wall of the collection box (24).

4. A microorganism separation device for biopharmaceutical detection according to claim 1, characterized in that: The water supply mechanism (26) further comprises a water supply mechanism (26), wherein the water supply mechanism (26) comprises a movable plate (27) which contacts and fits with the top of the cam (19), one end of the movable plate (27) passes through the box body and extends to the second movable plate (28), and the movable plate (27) is provided with a strip groove along the height direction of the inner wall of the box body, the top of the second movable plate (28) and a fixed plate (29) installed on the inner wall of the box body are connected via a second spring (30), and the bottom of the second movable plate (28) is connected to a retaining ring (32) arranged on the inner wall of the guide tube (31) via a bracket.

5. A microorganism separation device for biopharmaceutical detection according to claim 4, characterized in that: One end of the conduit (31) is connected to a water storage tank (34) disposed inside the box body via a U-shaped tube (33), and the other end is connected to a water outlet via a multi-way tube.

6. A microorganism separation device for biopharmaceutical detection according to claim 5, characterized in that: A culture dish (35) is provided below the water outlet and is placed inside the box (1); the culture dishes (35) are connected to each other via columns, and the bottom of the column passes through the culture dish (35) and extends to the bottom end of the inner wall of the box (1).

7. A microorganism separation device for biopharmaceutical detection according to claim 1, characterized in that: Cushion blocks are installed around the bottom of the box body (1), and elastic plates are connected to the cushion blocks by means of adhesive installation.

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