External traditional Chinese medicine composition for treating traumatic injury as well as preparation method and application of external traditional Chinese medicine composition

Abstract

The invention discloses an external traditional Chinese medicine composition for treating traumatic injury and a preparation method and application thereof, belongs to the technical field of traditional Chinese medicine, and particularly comprises the following raw materials: paniculate swallowwort root, radix angelicae, liquorice, semen brassicae and borneol. The total amount of the semen brassicae and the borneol is 30-40% of the total amount of the radix cynanchi paniculati, the radix angelicae and the liquorice root. The traditional Chinese medicine composition is developed on the basis of the original paniculate swallowwort root, radix angelicae and liquorice root, on one hand, the semen brassicae and the borneol are added to synergistically increase the transdermal absorption of the medicine; on the other hand, the semen brassicae has the effects of activating meridians to stop pain, the borneol has the effects of relieving pain and clearing heat, and the semen brassicae and the borneol are matched with the radix cynanchi paniculati, the radix angelicae dahuricae and the liquorice, so that a synergistic interaction effect is generated in the aspects of relieving pain and improving traumatic injuries. Compared with the prior art, the traditional Chinese medicine composition has better effects on relieving pain and treating traumatic injuries.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to an external Chinese medicine composition for treating traumatic injuries, and a preparation method and application thereof. Background Art

[0002] Traumatic injuries include injuries caused by knives, guns, beatings, sprains, stab wounds, abrasions, sports injuries, etc. The injuries are usually painful, swollen, bleeding, or fractures, dislocations, etc. They also include some internal organ injuries, mainly soft tissue injuries. Clinical manifestations: pain, swelling, deformity, dysfunction, extremely serious harm to people's health. Due to severe pain and a long course of illness, patients suffer great pain and have long-term inconvenience in activities.

[0003] CN10127908A discloses a pharmaceutical composition for treating cervical spondylosis, lumbar spondylosis and traumatic injury and a preparation method thereof, wherein the raw materials of the medicine are composed of: angelica, frankincense, myrrh, chuanxiong, angelica dahurica, motherwort, fructus aurantii, cinnamon bark, acanthopanax bark, sophora flavescens, schizonepeta, chinensis bark, siler, tangerine peel, notoginseng, herba zedoariae, white peony root, radix polygoni multiflori, spatholobi, bupleurum, curcuma, and liquorice. The pharmaceutical composition of the invention has the effects of treating traumatic injury, cervical spondylosis and lumbar spondylosis, and has the effects of promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, removing toxins and removing rot, promoting tissue regeneration and healing sores, transforming hard masses and dispersing nodules, and dispersing blood stasis and promoting new growth. CN105012750A discloses a Chinese herbal wine for relieving pain in traumatic injuries, and its raw medicinal materials are: 45 parts of Chuanwu, 45 parts of Caowu, 45 parts of Baizhi, 45 parts of Fangji, 45 parts of Ligusticum chuanxiong, 45 parts of Smilax glabra, 45 parts of Cynanchum wilfordii, 40 parts of Lophatherum gracile, 40 parts of Morus alba, 40 parts of Rehmannia glutinosa, 40 parts of Epimedium, 40 parts of White Peony, 50 parts of Angelica sinensis, 50 parts of Cinnamomum cassia, 50 parts of Eucommia ulmoides, 50 parts of Liquorice, 50 parts of Dipsacus asper, and 3000 parts of liquor. The Chinese herbal wine for relieving pain in traumatic injuries has the effects of relaxing muscles and activating blood circulation, removing blood stasis and relieving pain, and dispelling wind and dampness, and is effective in treating traumatic injuries, muscle and bone pain, limb numbness, soreness of waist and legs, and the like.

[0004] In daily life, traumatic injuries often occur, and there is a great market demand for products that reduce swelling and relieve pain, and promote blood circulation and dissipate blood stasis. It is of great significance to develop a more effective external Chinese medicine composition for treating traumatic injuries based on traditional prescriptions.

[0005] CN116763834A discloses a Chinese medicine composition for treating joint pain, wherein the raw materials of the composition are composed of the following components: Cynanchum chinense, Angelica dahurica and Licorice. The composition has certain analgesic and anti-inflammatory effects and can be used for pain caused by joint pain, scapulohumeral periarthritis and lumbar disc herniation. At present, its use in treating traumatic injuries has not been found. Summary of the invention

[0006] In order to solve the above technical problems, the present invention provides a Chinese medicine composition for external use for treating traumatic injuries, and a preparation method and application thereof.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides a Chinese medicine composition for external use for treating traumatic injuries, comprising the following raw materials: Cynanchum chinense, Angelica dahurica, Licorice, Sinapis alba and Borneol.

[0009] In some embodiments, the total amount of white mustard seeds and borneol is 30-40% of the total amount of Cynanchum chinense, Angelica dahurica and Licorice; preferably 32-38%; further preferably 35-37%.

[0010] In some embodiments, the mass ratio of white mustard seeds to borneol is 2-7:1; preferably 2.3-7:1; and further preferably 4:1.

[0011] In some embodiments, the mass ratio of Cynanchum chinense, Angelica dahurica and Licorice is: 20-40:20-40:8-20; preferably 25-35:25-35:8-15; further preferably 28-32:28-32:8-12.

[0012] In some embodiments, the total amount of white mustard and borneol in the external Chinese medicine composition is 30% of the total amount of Cynanchum chinense, Angelica dahurica and Licorice; the mass ratio of white mustard and borneol is 4:1; the mass ratio of Cynanchum chinense, Angelica dahurica and Licorice is: 20-40:20-40:8-20.

[0013] In some embodiments, the total amount of white mustard and borneol in the traditional Chinese medicine composition is 30% of the total amount of Cynanchum chinense, Angelica dahurica and Licorice; the mass ratio of white mustard and borneol is 4:1; the mass ratio of Cynanchum chinense, Angelica dahurica and Licorice is: 28-32:28-32:8-12.

[0014] In a second aspect, the present invention provides a method for preparing the external Chinese medicine composition, comprising the following steps:

[0015] (1) extracting the formulated amount of Cynanchum chinense, Angelica dahurica and Glycyrrhiza uralensis with alcohol, separating the solid and the liquid, and obtaining an alcohol extract and a residue;

[0016] (2) mixing the residue obtained in step (1) with a formulated amount of white mustard seeds, extracting with water, and separating the solid from the liquid to obtain a water extract;

[0017] (3) concentrating the aqueous extract obtained in step (2), and precipitating with alcohol to obtain a supernatant;

[0018] (4) The supernatant obtained in step (3) and the alcohol extract obtained in step (1) are combined and concentrated, and a formulated amount of borneol is added and mixed to obtain the external Chinese medicine composition.

[0019] In some embodiments, the alcohol extraction in step (1) is: extracting at least once with 80-95% ethanol by volume; preferably, the extraction temperature is 50-70°C, and the amount of ethanol added is 5-12 times the total amount of Cynanchum chinense, Angelica dahurica and Glycyrrhiza uralensis.

[0020] In some embodiments, the water extraction in step (2) is: decocting with water at least once; preferably, the amount of water added is 6-8 times the total amount of Cynanchum chinense, Angelica dahurica, Glycyrrhiza uralensis and Sinapis alba.

[0021] In some embodiments, the concentration in step (3) is: concentration under reduced pressure (-0.08 to -0.09 MPa) at 50-70°C to a relative density of 1.03-1.05.

[0022] In some embodiments, the alcohol precipitation in step (3) is as follows: adding 60-95% ethanol by volume to make the alcohol content 60-70 v / v%, mixing well and letting stand overnight.

[0023] In some embodiments, the concentration in step (4) is: concentration under reduced pressure (-0.08 to -0.09 MPa) at 50-70°C to a relative density of 1.10-1.12.

[0024] The solid-liquid separation mentioned in the present invention is a conventional technical means in the art, and its purpose is to achieve separation of solid and liquid. Therefore, the present invention is not limited to its specific implementation method, and centrifugation, filtration or filter pressing can be selected according to actual needs.

[0025] In a third aspect, the present invention also provides the use of the above-mentioned external Chinese medicine composition in the preparation of a medicament for treating traumatic injuries.

[0026] In a fourth aspect, the present invention further provides a medicament for treating traumatic injuries, comprising the above-mentioned external Chinese medicine composition and pharmaceutically acceptable excipients.

[0027] Preferably, the medicament is a spray, a liniment, a tincture, a plaster, an ointment, a wet compress, a paste or a lotion.

[0028] The beneficial effects of the present invention are:

[0029] (1) The present invention is developed on the basis of the original Cynanchum chinense, Angelica dahurica and Licorice. On the one hand, by adding white mustard seeds and borneol, the transdermal absorption of the drug is synergistically increased; on the other hand, white mustard seeds have the effect of dredging meridians and relieving pain, and borneol has the effect of relieving pain and clearing heat. The combination of white mustard seeds and borneol with Cynanchum chinense, Angelica dahurica and Licorice produces a synergistic effect in relieving pain and improving traumatic injuries.

[0030] (2) Compared with the prior art, the present invention has better effects in relieving pain and treating traumatic injuries. DETAILED DESCRIPTION

[0031] The following examples are only used to help understand the method of the present invention and its core idea. It should be noted that for those of ordinary skill in the art, without departing from the principles of the present invention, the present invention may also be subjected to several improvements and modifications, which also fall within the scope of protection of the claims of the present invention. The following description of the disclosed embodiments enables professionals and technicians in this field to implement or use the present invention. It will be apparent to professionals and technicians in this field that various modifications to these embodiments, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but may be applied to a wider range consistent with the principles and novel features disclosed herein. Although any methods and materials similar or equivalent to those described in the present invention may be used in the implementation or testing of the present invention, preferred methods and materials are listed herein.

[0032] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention belongs. The white mustard seeds in the present invention are raw white mustard seeds that have not been roasted.

[0033] Example 1 A Chinese medicine composition for external use for treating traumatic injury

[0034] Table 1: Formula of the external Chinese medicine composition of Example 1

[0035]

[0036]

[0037] The preparation method of the Chinese medicine combination is:

[0038] (1) adding 10 times the amount of 90% ethanol to the formulated amount of Cynanchum chinense, Angelica dahurica and Glycyrrhiza uralensis, extracting with alcohol at 70° C. for 2 h, filtering to obtain an alcohol extract and a residue;

[0039] (2) mixing the residue obtained in step (1) with the formulated amount of white mustard seeds, adding 7 times the amount of water, boiling for 1 hour, filtering, and obtaining a water extract;

[0040] (3) The aqueous extract obtained in step (2) was concentrated at 60° C. under reduced pressure (−0.08 MPa) to a relative density of 1.04, 80% ethanol was added to make the alcohol content 65%, and the mixture was mixed and allowed to stand overnight to obtain a supernatant;

[0041] (4) The supernatant obtained in step (3) and the alcohol extract obtained in step (1) are combined, concentrated under reduced pressure (-0.08 MPa) at 60° C. to a relative density of 1.11, and the formulated amount of borneol is added and mixed to obtain the external Chinese medicine composition.

[0042] Example 2 A Chinese medicine composition for external use for treating traumatic injuries

[0043] Table 2: Formula of the external Chinese medicine composition of Example 2

[0044] raw material Dosage Xu Changqing 20 servings Angelica dahurica 20 servings Licorice 8 servings The proportion of white mustard and borneol in the above three 30％ White mustard seeds 10 servings Borneol 4.4 servings

[0045] The preparation method of the Chinese medicine combination is basically the same as that of Example 1.

[0046] Example 3 A Chinese medicine composition for external use for treating traumatic injuries

[0047] Table 3: Formula of the external Chinese medicine composition of Example 3

[0048] raw material Dosage Xu Changqing 40 servings Angelica dahurica 40 servings Licorice 20 servings The proportion of white mustard and borneol in the above three 40％ White mustard seeds 35 servings Borneol 5 servings

[0049] The preparation method of the external Chinese medicine combination is basically the same as that of Example 1.

[0050] Comparative Example 1: A Chinese medicine composition for external use for treating traumatic injuries

[0051] Table 4: Formula of the external Chinese medicine composition of the comparative example

[0052] raw material Dosage Xu Changqing 0 copies Angelica dahurica 0 copies Licorice 0 copies The proportion of white mustard and borneol in the above three 100％ White mustard seeds 20 servings Borneol 5 servings

[0053] The preparation method of the external Chinese medicine combination is basically the same as that of Example 1.

[0054] Comparative Example 2: A Chinese medicine composition for external use for treating traumatic injuries

[0055] Table 5: Formula of the external Chinese medicine composition of the comparative example

[0056] raw material Dosage Xu Changqing 30 servings Angelica dahurica 30 servings Licorice 10 servings The proportion of white mustard and borneol in the above three 30％ White mustard seeds 25 servings Borneol 0 copies

[0057] The preparation method of the external Chinese medicine combination is basically the same as that of Example 1.

[0058] Comparative Example 3: A Chinese medicine composition for external use for treating traumatic injuries

[0059] Table 6: Formula of the external Chinese medicine composition of the comparative example

[0060] raw material Dosage Xu Changqing 30 servings Angelica dahurica 30 servings Licorice 10 servings The proportion of white mustard and borneol in the above three 30％ White mustard seeds 0 copies Borneol 25 servings

[0061] The preparation method of the external Chinese medicine combination is basically the same as that of Example 1.

[0062] Comparative Example 4: A Chinese medicine composition for external use for treating traumatic injuries

[0063] Table 7 Comparative Example of external Chinese medicine composition formula

[0064] raw material Dosage Xu Changqing 30 servings Angelica dahurica 30 servings Licorice 10 servings The proportion of white mustard and borneol in the above three 20％ White mustard seeds 10 servings Borneol 4 servings

[0065] The preparation method of the external Chinese medicine combination is basically the same as that of Example 1.

[0066] Comparative Example 5: A Chinese medicine composition for external use for treating traumatic injuries

[0067] Table 8: Formula of the external Chinese medicine composition of the comparative example

[0068] raw material Dosage Xu Changqing 30 servings Angelica dahurica 30 servings Licorice 10 servings The proportion of white mustard and borneol in the above three 50％ White mustard seeds 30 servings Borneol 5 servings

[0069] The preparation method of the external Chinese medicine combination is basically the same as that of Example 1.

[0070] Comparative Example 6 A Chinese medicine composition for treating joint pain was prepared by referring to the preparation method of Example 1 in CN116763834A to obtain an extract with a relative density of 1.10-1.30.

[0071] 1. Evaluation of analgesic effect

[0072] 1. Test samples

[0073] The external Chinese medicine compositions prepared in Examples 1-3 and Comparative Examples 1-6.

[0074] 2. Experimental Animals

[0075] ICR mice, weighing 20-26 g, male, were purchased from Guangdong Weitonglihua Experimental Animal Technology Co., Ltd.

[0076] 3. Test methods

[0077] ICR mice were randomly divided into normal group, model group and drug group according to body weight. The drug group was smeared with 0.1 mL of the corresponding drug (2.6 g crude drug / mL) on the two hind toes of the mice once a day for 3 consecutive days. The other groups were smeared with 0.1 mL of normal saline.

[0078] One hour after the last administration, except for the normal control group, which was injected with saline, 25 μL of 4% formaldehyde-saline solution was subcutaneously injected into the plantar of the right hind paw of mice in the other groups. Immediately after the injection, the mice were placed in a large beaker for observation for 30 minutes. Each 5-minute period was recorded as a time period. The cumulative time of pain response in each time period was recorded, that is, the cumulative time when the right hind paw of the mouse was not in contact with the bottom of the beaker and was in the state of licking, lifting or biting the paw. The cumulative pain response time of phase I reaction (0-5 minutes, neuralgia) and phase II reaction (10-30 minutes, inflammatory pain) was calculated.

[0079] The results are shown in Table 9.

[0080] Table 9 Effects of external Chinese medicine composition on formaldehyde analgesia model mice (mean ± standard deviation)

[0081] Group Number Phase I reaction time (s) Phase II reaction time (s) normal 8 0d 0d Model 8 182±46a 612±97a Example 1 8 35±18c 30±19c Example 2 8 46±25c 35±18c Example 3 8 40±20c 31±16c Comparative Example 1 8 173±50a 586±90a Comparative Example 2 8 74±39b 48±27b Comparative Example 3 8 70±40b 42±31b Comparative Example 4 8 65±35b 43±28b Comparative Example 5 8 85±42b 56±20b Comparative Example 6 8 81±37b 50±24b

[0082] Note: Different letters in the same column indicate significant differences among the groups (P < 0.05).

[0083] The results showed that compared with the normal group, the cumulative pain reaction time of phase I reaction and the cumulative pain reaction time of phase II reaction in the model group mice were significantly different (P < 0.05), indicating that the model was successfully established.

[0084] Compared with the model group, except for Comparative Example 1, the cumulative pain reaction time of Phase I reaction and the cumulative pain reaction time of Phase II reaction of each group of mice showed significant differences (P<0.05), indicating that except for the external Chinese medicine composition provided in Comparative Example 1, the external Chinese medicine compositions provided by other groups all have analgesic effects.

[0085] By comparing the example group and the comparative example group, it was found that compared with comparative example 6, the cumulative pain reaction time of phase I reaction and the cumulative pain reaction time of phase II reaction of mice in each group of examples 1-3 were significantly different (P < 0.05), indicating that the analgesic effect of the external Chinese medicine composition provided by examples 1-3 is better than that of the prior art.

[0086] By comparing the comparative example 1-5 groups with the comparative example 6 group, it was found that compared with the comparative example 6 group, there was no significant difference in the cumulative pain reaction time of phase I reaction and the cumulative pain reaction time of phase II reaction in the mice in each group of comparative examples 1-5 (P>0.05), indicating that the analgesic effect of the external Chinese medicine composition provided by comparative examples 1-5 is basically the same as that of the prior art.

[0087] Comparison of Example 1 and Comparative Examples 1-3 shows that the combination of white mustard seeds and borneol with Cynanchum chinense, Angelica dahurica and Licorice produces a synergistic effect in analgesia.

[0088] 2. Evaluation of the effect of traumatic injury

[0089] 1. Test samples

[0090] The external Chinese medicine compositions prepared in Examples 1-3, Comparative Examples 1-3 and Comparative Example 6.

[0091] 2. Experimental Animals

[0092] SD rats, weighing 180-200 g, half male and half female.

[0093] 3. Test methods

[0094] After SD rats were anesthetized, the left and right forelimbs (from the foot to the knee joint) were depilated. After depilation, the rats' limbs were fixed, and the left forelimb was externally rotated so that the posterior group muscle was placed inside the tibia and fibula. The muscle contusion of the left forelimb of the rat was performed by free fall of a weight, which was repeated 15 times to cause blunt soft tissue injury to the left forelimb of the rat.

[0095] The rats were randomly divided into a model group and a drug group after modeling. The drug group was smeared with 0.5 ml of the corresponding drug (2.6 g crude drug / ml), and the model group was smeared with an equal volume of normal saline. Every morning and evening (8:00 and 20:00), the injured part of the rat was wiped with a cotton ball dipped in the drug, and the injured part of the rat was covered to prevent the rat from licking it. The drug was administered for 5 consecutive days.

[0096] 12 hours after the last administration, the left forelimb of the rats was evaluated for injury:

[0097] Injury scoring standards and injury index

[0098] Swelling degree: no swelling is 0 points, mild swelling is 1 point, and severe swelling is 2 points.

[0099] Subcutaneous hemorrhage: no hemorrhage is 0 points, a small amount of dot-like hemorrhage is 1 point, and the rest are 2 points; among them, hemorrhage less than 5 dots is a small amount, and the dot-like hemorrhage radius is less than 0.5mm.

[0100] Functional impairment: no lameness: 0 points, mild lameness: 1 point, severe lameness: 2 points.

[0101] Tenderness response: no tenderness was 0 points, mild tenderness was 1 point, and severe tenderness was 2 points.

[0102] Injury index = 0.2 × average score of swelling degree + 0.2 × average score of subcutaneous congestion + 0.3 × average score of functional impairment + 0.3 × average score of tenderness reaction.

[0103] Among them, a damage index greater than 1.5 indicates that the modeling is successful. The smaller the damage index after treatment, the better the treatment effect. When the damage index is less than 1, it indicates that the drug has a therapeutic effect. The smaller the damage index, the better the treatment effect.

[0104] The results are shown in Table 10.

[0105] Table 10 Effect of external Chinese medicine composition on traumatic injury in rats

[0106] Group Number Pre-treatment injury index Post-treatment injury index Model 8 1.59 1.23 Example 1 8 1.62 0.26 Example 2 8 1.56 0.30 Example 3 8 1.65 0.34 Comparative Example 1 8 1.61 1.20 Comparative Example 2 8 1.64 0.84 Comparative Example 3 8 1.60 0.80 Comparative Example 6 8 1.57 0.86

[0107] The results showed that the external Chinese medicine compositions prepared in Examples 1-3 of the present invention all had therapeutic effects on rats with acute soft tissue injury models, and the injury index after treatment was less than 1. At the same time, Example 1 had the best therapeutic effect.

[0108] By comparing Comparative Examples 1-3 with Example 1, it can be seen that the injury index of rats with acute soft tissue injury model treated with the external Chinese medicine composition of white mustard and borneol, Cynanchum chinense, Angelica dahurica, licorice and white mustard, or Cynanchum chinense, Angelica dahurica, licorice and borneol is much lower than that of the external Chinese medicine composition provided in Example 1, indicating that the white mustard and borneol of the present invention cooperate with Cynanchum chinense, Angelica dahurica and licorice to produce a synergistic effect in improving traumatic injuries, and the effect of treating soft tissue injuries is better.

[0109] The above is a further description of the present invention in conjunction with specific embodiments, but these embodiments are merely exemplary and do not constitute any limitation on the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the technical solution of the present invention may be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for external use for treating traumatic injury, characterized in that: Including the following ingredients: Cynanchum cynanchum, Angelica dahurica, Licorice, White Mustard Seed and Borneol; the total amount of the White Mustard Seed and Borneol is 30-40% of the total amount of Cynanchum cynanchum, Angelica dahurica and Licorice.

2. The external Chinese medicine composition according to claim 1, characterized in that: The total amount of white mustard seeds and borneol is 32-38% of the total amount of Cynanchum cyrtonema, Angelica dahurica and Licorice.

3. The external Chinese medicine composition according to claim 1, characterized in that: The mass ratio of white mustard seeds to borneol is 2-7:

1.

4. The external Chinese medicine composition according to claim 1, characterized in that: The mass ratio of Cynanchum cyrtonema, Angelica dahurica and Licorice is 20-40:20-40:8-20.

5. The external Chinese medicine composition according to claim 1, characterized in that: The total amount of white mustard seeds and borneol is 30% of the total amount of Cynanchum cyrtonema, Angelica dahurica and Licorice; The mass ratio of white mustard seeds to borneol is 4:1; The mass ratio of Cynanchum chinense, Angelica dahurica and Licorice is: 20-40: 20-40: 8-20.

6. The method for preparing the external Chinese medicine composition according to any one of claims 1 to 5, characterized in that: The steps include: (1) extracting the formulated amount of Cynanchum chinense, Angelica dahurica and Glycyrrhiza uralensis with alcohol, separating the solid and the liquid, and obtaining an alcohol extract and a residue; (2) mixing the residue obtained in step (1) with a formulated amount of white mustard seeds, extracting with water, and separating the solid from the liquid to obtain a water extract; (3) concentrating the aqueous extract obtained in step (2), and precipitating with alcohol to obtain a supernatant; (4) The supernatant obtained in step (3) and the alcohol extract obtained in step (1) are combined and concentrated, and a formulated amount of borneol is added and mixed to obtain the external Chinese medicine composition.

7. The preparation method according to claim 6, characterized in that: The alcohol extraction in step (1) is: extracting at least once with 80-95% ethanol by volume; the extraction temperature is 50-70° C.; And / or, the water extraction in step (2) is: boiling with water at least once; And / or, the concentration in step (3) is: concentrating under reduced pressure at 50-70° C. to a relative density of 1.03-1.05; and / or, the alcohol precipitation in step (3) is: adding 60-95% ethanol by volume to make the alcohol content 60-70 v / v%, mixing and letting stand overnight.

8. Use of the Chinese medicine composition for external use according to any one of claims 1 to 5 or the Chinese medicine composition for external use prepared by the preparation method according to any one of claims 6 to 7 in preparing a medicament for treating traumatic injuries.

9. A medicament for treating traumatic injuries, characterized in that: The invention comprises the external Chinese medicine composition according to any one of claims 1 to 5 or the external Chinese medicine composition prepared by the preparation method according to any one of claims 6 to 7 and pharmaceutically acceptable excipients.

10. The drug according to claim 9, characterized in that The medicament is a spray, liniment, tincture, plaster, ointment, wet compress, paste or lotion.

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