Hydrogel mask containing silk fibroin and preparation method thereof

Abstract

The invention provides a preparation method of a hydrogel mask containing silk fibroin, and relates to the technical field of cosmetics. The silk fibroin hydrogel mask comprises the following main components: silk fibroin, polyvinyl alcohol and D-sorbitol. The preparation method of the silk fibroin hydrogel mask comprises the following steps: dissolving polyvinyl alcohol at high temperature; and adding silk fibroin and D-sorbitol, uniformly mixing, injecting into a mold, carrying out circulating freezing and thawing, and obtaining the silk fibroin hydrogel mask through a physical cross-linking method. The silk fibroin hydrogel mask disclosed by the invention has the advantages of good mechanical property, good viscoelasticity and toughness, mildness, skin friendliness, high water-retaining property and remarkable moisturizing effect, and can be directly used as a mask.

Description

Technical Field

[0001] The invention relates to the field of cosmetic facial masks, and in particular to a hydrogel facial mask containing silk fibroin and a preparation method thereof. Background Art

[0002] Facial masks are a category of skin care products, which have many functions such as hydrating, moisturizing, providing nutrition to the skin, improving appearance, deep cleansing, etc. At present, ordinary non-woven fabrics and silk masks are more common on the market, but non-woven patch masks still have the following problems: First, in the rapid development of the facial mask market, it is inevitable that some businesses will add thickeners such as carbomer, preservatives such as phenoxyethanol and fragrances to make the essence viscous, long-lasting and fragrant in order to maximize profits, but this often leads to various skin problems, such as facial irritation and dermatitis; second, the essence is the main ingredient of the mask. Due to the insufficient water absorption and water retention of the membrane cloth, the essence is easy to drip and cannot be fully and effectively absorbed by the skin. In addition, the water contained in the membrane cloth will evaporate quickly, which is easy to cause reverse osmosis, causing the membrane cloth to obtain water from the skin instead. Silk mask cloth has good air permeability and water absorption, but real silk mask cloth is easy to break, has no stretchability, poor molding and high cost, which limits its use. Hydrogel mask can avoid the above problems and is increasingly favored by consumers.

[0003] Silk fibroin has high biocompatibility, low immunogenicity, good air permeability, excellent water absorption capacity, low cost and excellent physical and chemical properties, so it is very suitable as a substrate for hydrogel masks. However, single-component silk fibroin hydrogel still has some defects, such as its relative fragility and poor elasticity, so the mechanical properties are not ideal, the gel quality is poor, and the molding rate is low. Therefore, combining with some other natural or synthetic polymers is an effective way to improve the properties including elasticity, enhancing biological activity and adhesion. Polyvinyl alcohol (PVA) is a synthetic polymer with excellent water solubility. D-sorbitol is the most commonly used cosmetic moisturizer, and its hygroscopicity is less than glycerol. It can improve the cold stability of the mask and has excellent antifreeze properties. It can exert its moisturizing properties under low temperature conditions, and the moisturizing effect is very mild. Therefore, this experiment uses silk fibroin, polyvinyl alcohol and sorbitol as the substrate to prepare a hydrogel mask. Summary of the invention

[0004] The purpose of the present invention is to provide a hydrogel mask containing silk fibroin and a preparation method thereof, which is made from silk fibroin, polyvinyl alcohol and D-sorbitol and has good mechanical properties, good viscoelasticity and toughness, is mild and skin-friendly, has high water retention and significant moisturizing effect, and can be directly used as a facial mask.

[0005] A hydrogel mask containing silk fibroin and a preparation method thereof, comprising the following steps:

[0006] Step (1): Add polyvinyl alcohol (PVA) into deionized water and stir magnetically in a water bath at 80°C to 90°C for 1 h to 2 h until it is completely dissolved;

[0007] Step (2): Cooling the solution in step (1) to 50°C-60°C in a water bath;

[0008] Step (3): Add silk fibroin (SF) and D-sorbitol to the solution of step (2), and stir magnetically in a water bath at 50°C to 60°C for 1 h to 2 h until completely dissolved, to obtain a facial mask original solution;

[0009] Step (4): transfer the original mask solution obtained in step (3) into a mold, and freeze it at -20°C to -25°C for 2h to 3h, and then thaw it at room temperature for 1h to 2h;

[0010] Step (5): freeze-thaw the sample in step (4) for 4 to 5 times, and then take out the sample from the mold to obtain a hydrogel mask with silk fibroin as the main raw material.

[0011] In the step (1), the mass concentration of polyvinyl alcohol (PVA) is 5% to 6%;

[0012] In step (3), the mass concentration of silk fibroin (SF) is 1% to 4%;

[0013] The mass concentration of D-sorbitol in step (3) is 4% to 5%.

[0014] The present invention has the following beneficial effects:

[0015] The highly moisturizing, cooling and soothing, and antioxidant hydrogel mask prepared by the present invention uses raw material components with high biocompatibility, low immunogenicity, good air permeability, excellent water absorption capacity, low cost and excellent physical and chemical properties, and the surface viscosity and mechanical strength are suitable, the film-forming property and stretchability meet the use requirements, and the peeling integrity is good, so it is very suitable as a substrate for the hydrogel mask.

[0016] The mask of the present invention completely fits the face shape of the consumer, and solves the problems of the facial mask not being close enough to the skin, the mask cloth being too large, the material being too rough, the mask cloth being allergic, etc. The hydrogel mask prepared by the present invention will not dissolve in water after being formed, and has the advantages of good adhesion, elasticity and air permeability, etc., effectively reducing the risk of skin damage caused by peeling off the mask, and the mask can be peeled off completely and perfectly. DETAILED DESCRIPTION

[0017] To further illustrate the present invention, the hydrogel mask with polyvinyl alcohol, silk fibroin and D-sorbitol as main raw materials and the preparation method thereof provided by the present invention are described in detail below in conjunction with the examples.

[0018] Example 1

[0019] A hydrogel mask containing silk fibroin and a preparation method thereof, the method specifically comprising the following steps:

[0020] Step (1) Add 1.2 g of polyvinyl alcohol (PVA) into deionized water and stir magnetically in a water bath at 80°C to 90°C for 1 h to 2 h until it is completely dissolved;

[0021] Step (2) cooling the solution in step (1) to 50°C to 60°C in a water bath;

[0022] Step (3) adding 0.2 g of silk fibroin (SF) and 1 g of D-sorbitol to the solution of step (2), stirring magnetically in a water bath at 50°C to 60°C for 1 h to 2 h until completely dissolved, to obtain a facial mask original solution;

[0023] Step (4) transferring the mixed solution obtained in step (3) into a mold, and freezing it at -20°C to -25°C for 2h to 3h, and then thawing it at room temperature for 1h to 2h;

[0024] Step (5) freeze-thaw the sample in step (4) for 4 to 5 times, and then take out the sample from the mold to obtain a hydrogel mask with silk fibroin as the main raw material.

[0025] Example 2

[0026] A hydrogel mask containing silk fibroin and a preparation method thereof, the method specifically comprising the following steps:

[0027] Step (1) Add 1.2 g of polyvinyl alcohol (PVA) into deionized water and stir magnetically in a water bath at 80°C to 90°C for 1 h to 2 h until it is completely dissolved;

[0028] Step (2) cooling the solution in step (1) to 50°C to 60°C in a water bath;

[0029] Step (3) adding 0.4 g silk fibroin (SF) and 1 g D-sorbitol to the solution of step (2), stirring magnetically in a water bath at 50°C to 60°C for 1 h to 2 h until completely dissolved, to obtain a facial mask original solution;

[0030] Step (4) transferring the mixed solution obtained in step (3) into a mold, and freezing it at -20°C to -25°C for 2h to 3h, and then thawing it at room temperature for 1h to 2h;

[0031] Step (5) freeze-thaw the sample in step (4) for 4 to 5 times, and then take out the sample from the mold to obtain a hydrogel mask with silk fibroin as the main raw material.

[0032] Example 3

[0033] A hydrogel mask containing silk fibroin and a preparation method thereof, the method specifically comprising the following steps:

[0034] Step (1) Add 1.2 g of polyvinyl alcohol (PVA) into deionized water and stir magnetically in a water bath at 80°C to 90°C for 1 h to 2 h until it is completely dissolved;

[0035] Step (2) cooling the solution in step (1) to 50°C to 60°C in a water bath;

[0036] Step (3) adding 0.6 g of silk fibroin (SF) and 1 g of D-sorbitol to the solution of step (2), and stirring with a magnetic force in a water bath at 50°C to 60°C for 1 h to 2 h until completely dissolved, to obtain a facial mask original solution;

[0037] Step (4) transferring the mixed solution obtained in step (3) into a mold, and freezing it at -20°C to -25°C for 2h to 3h, and then thawing it at room temperature for 1h to 2h;

[0038] Step (5) freeze-thaw the sample in step (4) for 4 to 5 times, and then take out the sample from the mold to obtain a hydrogel mask with silk fibroin as the main raw material.

[0039] Example 4

[0040] A hydrogel mask containing silk fibroin and a preparation method thereof, the method specifically comprising the following steps:

[0041] Step (1) Add 1.2 g of polyvinyl alcohol (PVA) into deionized water and stir magnetically in a water bath at 80°C to 90°C for 1 h to 2 h until it is completely dissolved.

[0042] Step (2) cooling the solution in step (1) to 50°C to 60°C in a water bath;

[0043] Step (3) adding 0.8 g of silk fibroin (SF) and 1 g of D-sorbitol to the solution of step (2), and stirring with a magnetic force in a water bath at 50°C to 60°C for 1 h to 2 h until completely dissolved, to obtain a facial mask original solution;

[0044] Step (4) transferring the mixed solution obtained in step (3) into a mold, and freezing it at -20°C to -25°C for 2h to 3h, and then thawing it at room temperature for 1h to 2h;

[0045] Step (5) freeze-thaw the sample in step (4) for 4 to 5 times, and then take out the sample from the mold to obtain a hydrogel mask with silk fibroin as the main raw material.

[0046] Example 5

[0047] A hydrogel mask containing silk fibroin and a preparation method thereof, the method specifically comprising the following steps:

[0048] Step (1) Add 1.2 g of polyvinyl alcohol (PVA) into deionized water and stir magnetically in a water bath at 80°C to 90°C for 1 h to 2 h until it is completely dissolved;

[0049] Step (2) cooling the solution in step (1) to 50°C to 60°C in a water bath;

[0050] Step (3) adding 1 g of silk fibroin (SF) and 1 g of D-sorbitol to the solution of step (2), stirring magnetically in a water bath at 50°C to 60°C for 1 h to 2 h until completely dissolved, to obtain a facial mask original solution;

[0051] Step (4) transferring the mixed solution obtained in step (3) into a mold, and freezing it at -20°C to -25°C for 2h to 3h, and then thawing it at room temperature for 1h to 2h;

[0052] Step (5) freeze-thaw the sample in step (4) for 4 to 5 times, and then take out the sample from the mold to obtain a hydrogel mask with silk fibroin as the main raw material.

Claims

1. A method for preparing a hydrogel mask containing silk fibroin, characterized in that The method specifically comprises the following steps: (1) Add polyvinyl alcohol (PVA) to deionized water and stir magnetically in a water bath until completely dissolved; (2) Cooling the solution in step (1) to 50°C-60°C in a water bath; (3) adding silk fibroin (SF) and D-sorbitol to the solution of step (2), and stirring magnetically in a water bath until completely dissolved to obtain a mask original solution; (4) Transfer the original mask solution obtained in step (3) into a mold and freeze it at -20°C to -25°C for 2h to 3h, then dissolve it at room temperature for 1h to 2h after freezing; (5) The sample in step (4) is freeze-thawed repeatedly, and after completion, the sample is taken out from the mold to obtain a hydrogel mask with silk fibroin as the main raw material.

2. The method for preparing a hydrogel mask containing silk fibroin according to claim 1, characterized in that: The silk fibroin mass concentration described in step (3) is 1% to 4%.

3. The method for preparing a hydrogel mask containing silk fibroin according to claim 1, characterized in that: In the step (1), the mass concentration of polyvinyl alcohol (PVA) is 5% to 6%, the mass concentration of D-sorbitol is 4% to 5%, and the rest is water.

4. The method for preparing a hydrogel mask containing silk fibroin according to claim 1, characterized in that: In the step (1), the stirring temperature of polyvinyl alcohol (PVA) is 80°C-90°C, and the stirring time is 1 hour; in the step (3), the stirring temperature of silk fibroin (SF) and D-sorbitol is 50°C-60°C, and the stirring time is 1 hour.

5. The method for preparing a hydrogel mask containing silk fibroin according to claim 1, characterized in that: The number of freeze-thaw cycles in step (5) is 4 to 5 times.