Traditional Chinese medicine application product with cough relieving effect

Abstract

The invention relates to the field of cough-relieving traditional Chinese medicine application, in particular to a traditional Chinese medicine application product with a cough-relieving effect and a preparation method of the traditional Chinese medicine application product. The traditional Chinese medicine application product comprises the following raw materials: 10-15 parts of honey-fried ephedra, 2-6 parts of tussilago farfara, 2-6 parts of salvia miltiorrhiza, 2-6 parts of perilla leaf, 2-6 parts of corydalis tuber, 2-6 parts of semen brassicae, 4-8 parts of radix stemonae, 4-8 parts of rhizoma pinellinae praeparata, 4-8 parts of scutellaria baicalensis, 4-8 parts of aster, 5-10 parts of asarum, 4-8 parts of houttuynia cordata, 2-6 parts of schizonepeta and 15-30 parts of folium artemisiae argyi. According to the preparation method of the traditional Chinese medicine application product, different extraction technological processes are designed according to the characteristics of the traditional Chinese medicines, and the preparation method comprises the five steps of alcohol extraction, water extraction and alcohol precipitation, volatile oil extraction, medicine powder preparation and mixing concentration. The product relieves cough through traditional Chinese medicine acupoint application and transdermal administration absorption, oral administration is not needed, harm caused by side effects is avoided, the cough relieving effect is better than that of existing similar products, meanwhile, the defect that application type products are poor in effect is overcome, and the preparation process is safe and efficient.

Description

Technical Field

[0001] The invention relates to the field of Chinese medicine patch application, and in particular to a Chinese medicine patch application product with cough relieving effect. Background Art

[0002] In today's fast-paced life, people's daily routines are often disrupted. Bad living habits such as staying up late to work overtime, excessive entertainment, and irregular diet gradually reduce the body's resistance. The weakening of the immune system makes people more vulnerable to various diseases, among which coughing is one of the common symptoms. When the seasons change, the climate changes dramatically, the sudden rise and fall of temperature, and the obvious change of humidity have a huge impact on the human respiratory tract. From the hot summer to the cool autumn, or from the cold winter to the warm spring, the human body often finds it difficult to adapt to this change in a short period of time, and the respiratory mucosa is easily irritated, causing coughing. Especially for some people with weak constitutions and sensitive people, the change of seasons is a high incidence period of coughing. Moreover, after the epidemic, many people have experienced damage to the lungs caused by the virus. Although most patients gradually recover after recovery, some people still have different degrees of lung problems. Impaired lung function makes coughing one of the common sequelae. For the common symptom of cough, whether it is caused by colds, allergies or other respiratory diseases, it has brought great trouble to people's lives. These people with coughs not only face physical discomfort, but also suffer tremendous psychological pressure, worrying that coughing will cause more serious health problems.

[0003] In this context, the number of people suffering from coughs is increasing and becoming more frequent. People are in urgent need of a safe and effective treatment method to relieve cough symptoms and restore a healthy life. Existing oral cough suppressants are addictive or toxic, and side effects such as nausea, vomiting, and dizziness may occur after taking them, causing damage to the kidneys, liver, spleen, and stomach. Cough patch products have a single ingredient and a low proportion of Chinese medicine; or they are directly mixed with Chinese medicine powder without purification and have impurities, low concentration of effective substances, and large-particle powder is difficult to penetrate; or there is no heating pack to assist drug penetration, the drug's transdermal speed is low, and the effect is not obvious. Ordinary cough patch products are slow to take effect in the immediate improvement of coughs, and cannot immediately relieve customer discomfort. They are not effective in conditioning people with long-term coughs, and cannot eliminate the cold and dampness that has accumulated in the lungs for a long time from the root and deep. Summary of the invention

[0004] The purpose of the present invention is to provide a Chinese medicine patch product with antitussive effect and a preparation method to solve the problems existing in the prior art, and is suitable for coughs caused by various reasons. The present invention is aimed at the current situation that the number of people with coughs is increasing, oral cough suppressants have side effects, and ordinary cough patch products are not effective, and provides a safe and efficient Chinese medicine patch product with antitussive effect and a preparation method. By scientifically selecting medicinal materials and designing an extraction process according to the characteristics of each medicinal material, the prepared Chinese medicine patch product does not require oral administration, avoids side effects, and can effectively relieve coughs, which is better than existing similar products in terms of effect.

[0005] The invention provides a Chinese medicine patch product with an antitussive effect. The raw material Chinese medicine dressing product comprises: 10-15 parts of roasted ephedra, 2-6 parts of coltsfoot flowers, 2-6 parts of salvia miltiorrhiza, 2-6 parts of perilla leaves, 2-6 parts of corydalis, 2-6 parts of white mustard seeds, 4-8 parts of stemona, 4-8 parts of pinellia, 4-8 parts of scutellaria, 4-8 parts of aster, 5-10 parts of asarum, 4-8 parts of houttuynia, 2-6 parts of schizonepeta and 15-30 parts of wormwood.

[0006] Preferably, the composition and dosage ratio of the Chinese medicine patch dressing product include: 11-14 parts of roasted ephedra, 3-5 parts of coltsfoot flower, 3-5 parts of salvia miltiorrhiza, 3-5 parts of perilla leaves, 3-5 parts of Corydalis yanhusuo, 3-5 parts of white mustard seeds, 5-7 parts of Stemona, 5-7 parts of Pinellia, 5-7 parts of Scutellaria, 5-7 parts of Aster, 6-9 parts of Asarum, 5-7 parts of Houttuynia cordata, 3-5 parts of Schizonepeta, and 14-26 parts of Artemisia argyi.

[0007] The raw material composition of the Chinese medicine patch product of the present invention is determined based on the theory of traditional Chinese medicine and clinical practice experience, and the raw materials that strongly stimulate the skin are removed at the same time. Roasted ephedra has the effects of sweating and relieving the exterior symptoms, ventilating the lungs and relieving asthma; coltsfoot flower can moisten the lungs and lower the qi, relieve cough and resolve phlegm; salvia miltiorrhiza can promote blood circulation and remove blood stasis, promote menstruation and relieve pain; perilla leaf can relieve the exterior symptoms and dispel cold, promote qi and relieve fullness; corydalis has the effects of promoting blood circulation, promoting qi and relieving pain; white mustard can warm the lungs and dispel phlegm, promote qi and disperse knots; radix stemonae can moisten the lungs and relieve cough, kill insects and kill lice; pinellia can dry dampness and resolve phlegm, descend adverse and stop vomiting; scutellaria can clear away heat and dry dampness, purge fire and detoxify; aster can moisten the lungs and lower the qi, relieve cough and resolve phlegm; asarum can dispel wind and dissipate cold, open the orifices and relieve pain, warm the lungs and resolve phlegm; houttuynia can clear away heat and detoxify, eliminate carbuncle and discharge pus, promote diuresis and relieve stranguria; schizonepeta can relieve the exterior symptoms and dissipate wind, penetrate rash and eliminate sores; wormwood can warm the meridians and dissipate cold, regulate menstruation and relieve pain, and stabilize the fetus. These herbs work together synergistically to relieve cough.

[0008] The raw materials of the Chinese medicine prescription of the present invention are as follows: Roasted Ephedra: The herbaceous stems of Ephedra sinica, Ephedra intermedia or Ephedra equisetum of the Ephedraceae family are roasted with honey; Nature and flavor: pungent, slightly bitter, warm; enters the lung and bladder meridians. It has the effects of clearing the lungs and relieving asthma, promoting diuresis and reducing swelling. It is mainly used to treat colds, chest tightness, asthma and cough, and edema caused by wind and water.

[0009] Coltsfoot flower: the flower bud of the plant Coltsfoot of the Asteraceae family; nature and flavor: pungent, slightly bitter, warm; enters the lung meridian. It has the effects of moistening the lungs and lowering qi, relieving cough and reducing phlegm. It is mainly used to treat new and long-term cough, wheezing, coughing with phlegm, and coughing up blood due to fatigue.

[0010] Danshen: The root and rhizome of the plant Danshen of the Labiatae family; Nature and flavor: bitter, slightly cold; enters the heart and liver meridians. It has the effects of promoting blood circulation and removing blood stasis, relieving pain by promoting menstruation, clearing the heart and eliminating vexation, cooling blood and eliminating carbuncle. It is mainly used to treat chest pain, abdominal pain, accumulation of lumps, pain caused by heat, restlessness and insomnia, irregular menstruation, dysmenorrhea, amenorrhea, and swelling and pain of sores.

[0011] Perilla leaf: The leaves of the Lamiaceae plant Perilla; Nature and flavor: pungent, warm; enter the lung and spleen meridians. It has the effects of dispelling cold, promoting qi and harmonizing the stomach. It is mainly used to treat colds, coughs, nausea, vomiting during pregnancy, and fish and crab poisoning.

[0012] Corydalis yanhusuo: The tuber of Corydalis yanhusuo, a plant of the poppy family; nature and flavor: pungent, bitter, warm; belongs to the liver and spleen meridians. It has the effects of promoting blood circulation, promoting qi, and relieving pain. It is mainly used to treat chest and flank pain, abdominal pain, chest obstruction and heart pain, amenorrhea and dysmenorrhea, postpartum blood stasis, and swelling and pain due to falls.

[0013] White mustard seeds: seeds of the white mustard plant of the cruciferous family; nature and flavor: pungent, warm; enter the lung meridian. It has the effects of warming the lungs, dispelling phlegm and promoting qi, dispersing nodules and relieving pain. It is mainly used to treat asthma and cough caused by cold phlegm, distension and pain in the chest and ribs, phlegm stagnation in the meridians, numbness and pain in the joints, phlegm and dampness, and swelling and poison in the yin.

[0014] Stemona: The root of the plant Stemona erecta, Stemona creeping or Stemona opposite leaves of the Stemonaceae family; Nature and flavor: sweet, bitter, slightly warm; enters the lung meridian. It has the effects of moistening the lungs, lowering qi, relieving cough, killing insects and lice. It is mainly used to treat new and long-term cough, cough caused by tuberculosis, whooping cough; it is used externally to treat head lice, body lice, pinworm disease, and vaginal itching.

[0015] French Pinellia: processed Pinellia; Nature and flavor: pungent, warm; enters the spleen, stomach, and lung meridians. Has the effect of drying dampness and resolving phlegm. Indications: cough and asthma due to excessive phlegm, dizziness and palpitations due to phlegm, dizziness due to wind phlegm, and headache due to phlegm.

[0016] Scutellaria baicalensis: The root of the Lamiaceae plant Scutellaria baicalensis; Nature and flavor: bitter, cold; enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. It has the effects of clearing away heat and dampness, purging fire and detoxifying, stopping bleeding, and calming the fetus. It is mainly used to treat damp-heat, summer dampness, chest tightness and nausea, damp-heat fullness, diarrhea, jaundice, lung heat cough, high fever and thirst, blood heat vomiting and bleeding, carbuncle, sore, and fetal movement disorder.

[0017] Aster: The root and rhizome of Aster tataricus, a plant of the Asteraceae family; Nature and flavor: pungent, bitter, warm; enters the lung meridian. It has the effects of moistening the lungs and lowering qi, eliminating phlegm and relieving cough. It is mainly used to treat cough with excessive phlegm, new and long-term cough, and cough with blood due to fatigue.

[0018] Asarum: the whole herb of Asarum sieboldii, Asarum hanseungensis or Asarum chinense of the Aristolochiaceae family; nature and flavor: pungent, warm; enters the lung, kidney and heart meridians. It has the effects of dispelling cold, expelling wind and relieving pain, opening the orifices, warming the lungs and transforming fluid. It is mainly used to treat colds caused by wind and cold, headaches, toothaches, nasal congestion and runny nose, allergic rhinitis, sinusitis, rheumatic pain, phlegm and cough.

[0019] Houttuynia cordata: the aerial part of the plant Houttuynia cordata of the Saururaceae family; nature and flavor: pungent, slightly cold; enters the lung meridian. It has the effects of clearing away heat and detoxifying, eliminating carbuncle and draining pus, and promoting diuresis and relieving stranguria. It is mainly used to treat lung carbuncle with vomiting pus, phlegm-heat cough, heat dysentery, heat stranguria, carbuncle, swelling and ulcer.

[0020] Nepeta: The aerial part of Nepeta, a plant of the Labiatae family; Nature and flavor: pungent, slightly warm; enters the lung and liver meridians. It has the effects of dispelling wind, clearing rashes, and eliminating sores. It is mainly used to treat colds, headaches, measles, rubella, and the initial stage of sores.

[0021] Artemisia argyi: leaves of the plant Artemisia argyi of the Asteraceae family; nature and flavor: pungent, bitter, warm; slightly toxic; enters the liver, spleen, and kidney meridians. It has the effects of warming the meridians to stop bleeding, dispelling cold and relieving pain, and externally removing dampness and relieving itching. It is mainly used to treat vomiting blood, epistaxis, metrorrhagia, menorrhagia, fetal bleeding, cold pain in the lower abdomen, irregular menstruation, uterine cold and infertility, and external treatment of skin itching.

[0022] The Chinese medicine formula of the present invention is derived from the acupoint plaster therapy of Luo's secret recipe for relieving cough, clearing lungs and resolving phlegm. The above Chinese medicine raw materials work synergistically to completely remove various pathogenic factors in the lungs, and are suitable for treating coughs caused by various reasons; it comprehensively takes into account the basic causes of cold and dampness damaging the lungs, invasion of wind evils, and complications such as cold and dampness blocking the movement of yang qi leading to depression and heat, cold and dampness affecting the rise and fall of qi and blood circulation leading to blood stasis, and the inability of water and grain essence to be normally transported and transformed leading to phlegm and dampness, that is, it removes cold and dampness from the root, and simultaneously regulates various complications caused by cold and dampness, treats the symptoms and the root causes at the same time, and takes into account all lung problems.

[0023] The present invention also provides a method for preparing a Chinese medicine patch product with antitussive effect, comprising the following steps: S1 alcohol extraction: extracting effective ingredients from coltsfoot flower, salvia miltiorrhiza and perilla leaf by alcohol extraction method, wherein the alcohol extraction method adopts countercurrent extraction system: adding 60-85% ethanol, the solid-liquid ratio is 1:10-15g / ml, the extraction temperature is 50-70°C, and the extraction time is 2-4 hours; S2 water extraction and alcohol precipitation: extracting effective ingredients from Corydalis yanhusuo, white mustard seeds, Stemona tuber, Pinellia ternata, Scutellaria baicalensis, and Aster radix by water extraction and alcohol precipitation, wherein the water extraction and alcohol precipitation method is to first decoct in water for 1.5-3 hours, the amount of water used is 8-12 times the weight of the medicinal materials, filter to obtain a filtrate, and then perform alcohol precipitation on the filtrate, and the amount of ethanol used during the alcohol precipitation is 2-5 times the volume of the filtrate; S3 volatile oil extraction: extracting effective ingredients from Asarum, Houttuynia cordata and Nepeta tenuifolia by a volatile oil extraction method, wherein the volatile oil extraction method comprises adding water 8-12 times the weight of the medicinal materials, soaking for 2-4 hours and then performing steam distillation; S4 Preparation of medicinal powder: preparing medicinal powder by roasting ephedra and wormwood leaves; S5 Mixing and concentration: Mix the above-extracted active ingredients and powder, add licorice extract, stir and mix continuously until evenly mixed, and then concentrate to make an ointment.

[0024] The preparation method of the present invention designs different extraction process flows according to the characteristics of each Chinese medicine, obtains effective ingredients to the maximum extent, and finally mixes and concentrates to make ointments. The purification of Chinese medicine avoids the side effects caused by impurities, increases the content of effective substances, and ensures the high permeability of small molecule extracts, with better effects. In the preparation method provided by the present invention, alcohol extraction is performed on medicinal materials suitable for alcohol extraction, corresponding treatment is performed on medicinal materials suitable for water extraction and alcohol precipitation, and volatile oil extraction is performed on medicinal materials from which volatile oil can be extracted. Finally, the extracted effective ingredients are mixed and concentrated to make ointments for acupoint application, and the drugs are applied to specific acupoints through transdermal administration to exert the effects of cough relief and the like. The specific extraction method is: roasted ephedra is powder; coltsfoot flower, salvia miltiorrhiza, perilla leaf, corydalis, white mustard, stemona, pinellia ternata, scutellaria baicalensis, and aster are extracted by alcohol; corydalis, white mustard, stemona, pinellia ternata, scutellaria baicalensis, and aster are also extracted by water extraction and alcohol precipitation; asarum, houttuynia cordata, and schizonepeta are extracted by volatile oil; wormwood leaf is powder. The preparation method of the present invention utilizes the synergistic effect of multiple drugs to achieve comprehensive effects such as warming the lungs and dispelling cold, resolving phlegm and relieving cough, promoting blood circulation and removing blood stasis. The prepared ointment can be used as a traditional Chinese medicine patch product through local application to allow the effective ingredients of the drugs to be absorbed through the skin and exert their effects.

[0025] The countercurrent extraction system is used to make the ethanol solvent contact with the medicinal materials in a countercurrent manner. Fresh ethanol solvent is constantly in contact with medicinal materials with higher concentrations of active ingredients, while the extracted solution is in contact with medicinal materials with lower active ingredients, so that a larger concentration difference can be maintained and the extraction efficiency can be improved. Compared with the traditional alcohol extraction method, the countercurrent extraction system can more effectively promote the mass transfer process between the ethanol solvent and the medicinal materials. By reasonably controlling parameters such as flow rate and temperature, the contact between the solvent and the medicinal materials is more sufficient and uniform, reducing the situation of local excessive or low concentration, and further improving the extraction efficiency. During the entire extraction process, all parts of the medicinal materials can be fully contacted with the fresh ethanol solvent, avoiding the problem of incomplete extraction of active ingredients of some medicinal materials that may occur in the traditional alcohol extraction method, thereby improving the extraction rate of active ingredients. Because the extraction process is more uniform and sufficient, the loss of active ingredients during the extraction process is relatively small. The ketone components in the extraction of coltsfoot flower, salvia miltiorrhiza and perilla leaves will be destroyed due to local overheating or incomplete extraction in the traditional alcohol extraction process. They can be better extracted in the countercurrent extraction system, improving the quality and efficacy of the product.

[0026] The countercurrent extraction system can use ethanol solvent more efficiently by optimizing the contact mode and flow direction between the solvent and the medicinal materials. Under the premise of ensuring the extraction effect, compared with the traditional alcohol extraction method, less solvent can be used to achieve the same extraction effect, thereby saving the amount of solvent and reducing production costs. Less solvent usage not only saves costs, but also reduces the burden of subsequent processing steps such as concentration. In the process of concentrating the extract to make ointment, the lower solvent content means that less energy and time are required for concentration, which improves production efficiency.

[0027] At the same time, the countercurrent extraction system can ensure the uniformity of the extraction process, making the content and quality of the active ingredients obtained each time more stable. This is crucial for the production of high-quality Chinese medicine patch products, because stable product quality can ensure that its efficacy in cough relief and other aspects is more reliable and consistent. As the stability of the extraction process is improved, the differences between different batches of products will also be reduced accordingly. This helps to improve the market competitiveness of the product and meet consumers' requirements for product quality stability.

[0028] Preferably, the alcohol extraction method in step S1 adopts a countercurrent extraction system: adding ethanol with a concentration of 65-80%, a solid-liquid ratio of 1:11-14 g / ml, an extraction temperature of 55-65°C, and an extraction time of 3-4 hours; under this condition, the effective ingredients can be extracted to the maximum extent, while avoiding component loss and resource waste caused by over-extraction.

[0029] The specific operation of the countercurrent extraction system is as follows: slowly add the pretreated medicinal materials from the medicinal material feed port of the countercurrent extractor, and at the same time add the prepared ethanol solution from the solvent feed port at a certain flow rate, set the medicinal material feed flow rate to 1-3kg / h, and the solvent feed flow rate to 3-6kg / h; adjust the feed flow rates of the medicinal materials and the solvent so that the two maintain a suitable ratio and relative speed, so as to achieve a good countercurrent contact effect, and the flow rate of the solvent should be slightly higher than the flow rate of the medicinal materials, so as to ensure that the fresh solvent can fully contact the medicinal materials. Set the temperature of the countercurrent extractor to 55-65°C, keep the temperature stable through the heating device, use the temperature sensor to monitor the temperature in real time, and link with the heating device to ensure that the extraction process is carried out at an appropriate temperature. Control the countercurrent extraction time to 3-4 hours, record the extraction time through a timer or time monitoring device, and stop the extraction process when the set time is reached. After the extraction is completed, the extract flows out from the extract discharge port, and the extract is collected for subsequent treatment.

[0030] In the alcohol extraction step, by selecting the appropriate ethanol concentration, solid-liquid ratio, extraction temperature and time, the effective ingredients in coltsfoot flower, salvia miltiorrhiza and perilla leaf can be extracted to the maximum extent. The 70% ethanol concentration can dissolve the effective ingredients in the medicinal materials well, the 1:12 solid-liquid ratio ensures the adequacy of the extraction, and the 60°C extraction temperature and 3 hours of extraction time ensure the extraction effect while avoiding the loss of ingredients and waste of resources caused by over-extraction.

[0031] Preferably, the water extraction and alcohol precipitation method in step S2 is: first add water and boil for 2-3 hours, the amount of water used is 9-11 times the weight of the medicinal material, filter to obtain a filtrate, separate it using a microfiltration membrane and an ultrafiltration membrane, and then perform alcohol precipitation on the filtrate, the amount of ethanol used during alcohol precipitation is 2-3 times the volume of the filtrate; the microfiltration membrane is selected with a pore size of 0.1-1μm, and the transmembrane pressure can be set at 0.1-0.5MPa; the ultrafiltration membrane is selected with a molecular weight cutoff of 10-100kDa, a transmembrane pressure of 0.2-1MPa, and a membrane flux of 10-100L / (m²・h).

[0032] Through water extraction and alcohol precipitation, the active ingredients in medicinal materials can be effectively extracted, impurities can be removed, and the purity of the active ingredients can be improved.

[0033] In the water extraction and alcohol precipitation step, first add water to decoct for a suitable time and dosage, so that the effective ingredients in Corydalis yanhusuo, white mustard seeds, Stemona tuber, French pinellia, scutellaria baicalensis, and Aster radix can be fully dissolved in water. In the water extraction and alcohol precipitation process, after adding water to decoct and filtering to obtain the filtrate, microfiltration and ultrafiltration membranes are successively used to separate, and suspended particles, macromolecular impurities and impurities with larger molecular weight in the decoction are effectively removed, the purity of the filtrate is improved, and the interference of impurities in the subsequent alcohol precipitation process is reduced, thereby improving the purity and recovery rate of the effective ingredients. After filtering, the filtrate is subjected to alcohol precipitation treatment, impurities can be removed, and the purity of the effective ingredients can be improved. Add water to decoct for 2 hours, the amount of water is 10 times the weight of the medicinal material, and the amount of ethanol during alcohol precipitation is 2.5 times the volume of the filtrate, which can effectively extract the effective ingredients in the medicinal material, remove impurities, and improve the purity of the effective ingredients.

[0034] Use microfiltration membrane and ultrafiltration membrane for separation. Select a microfiltration membrane with a suitable pore size according to the characteristics of the medicinal materials and the properties of the filtrate. For the removal of suspended particles and larger molecular impurities in the decoction, a microfiltration membrane with a pore size between 0.1-1μm is selected. For extracts of medicinal materials such as Corydalis yanhusuo and white mustard containing more fibrous impurities, a microfiltration membrane with a pore size of 0.5μm can be selected. Microfiltration operation is carried out under appropriate pressure conditions, and the transmembrane pressure of microfiltration operation can be set between 0.1-0.5MPa. The filtrate after decoction is slowly introduced into the microfiltration device. Under the action of pressure, the suspended particles and large molecular impurities in the filtrate are retained on the surface of the microfiltration membrane, and the filtrate that passes through the microfiltration membrane enters the subsequent treatment link. During the microfiltration process, pay close attention to pressure changes and filtrate flow to ensure the stability and effectiveness of the operation.

[0035] For the removal of impurities with large molecular weights such as proteins and polysaccharides, select an ultrafiltration membrane with a suitable molecular weight cutoff, and select an ultrafiltration membrane with a molecular weight cutoff between 10-100kDa. For protein and polysaccharide impurities in the extracts of medicinal materials such as Stemona tuberosa and Pinellia ternata, select an ultrafiltration membrane with a molecular weight cutoff of 50kDa. Set appropriate ultrafiltration operating conditions, the transmembrane pressure of ultrafiltration is between 0.2-1MPa, and the membrane flux can be adjusted according to the properties of the filtrate and the processing volume, between 10-100L / (m²・h). The filtrate after microfiltration is introduced into the ultrafiltration device. Under the action of pressure, impurities with molecular weights greater than the molecular weight cutoff are retained on the surface of the ultrafiltration membrane, and the filtrate that passes through the ultrafiltration membrane is a further purified filtrate that can be used for subsequent alcohol precipitation treatment. During the ultrafiltration process, pay attention to monitoring pressure changes and filtrate flow to ensure smooth operation.

[0036] Preferably, the volatile oil extraction method in step S3 is: adding 9-11 times the weight of the medicinal material and 0.2%-2.0% of the weight of the medicinal material of a complex enzyme of cellulase and pectinase, adjusting the pH to 4.0-5.5 with a citric acid-sodium citrate buffer solution, and performing steam distillation after enzymatic soaking at 30-50°C for 3-4 hours. The volatile oil components in the medicinal material are extracted by steam distillation, and these volatile oil components play an important role in relieving cough.

[0037] In the volatile oil extraction step, add 10 times the weight of the medicinal material water, soak for 3 hours and then perform steam distillation to extract the volatile oil components in Asarum, Houttuynia cordata and Nepeta. These volatile oil components play an important role in relieving cough. The volatile oil components of Asarum, Houttuynia cordata and Nepeta can stimulate the respiratory mucosa and promote mucus secretion, thereby relieving cough. The enzymatic hydrolysis process can decompose or change the binding state of some substances bound to volatile oils in the cell, making it easier to extract volatile oils. The plant cell walls of Asarum, Houttuynia cordata and Nepeta contain components such as cellulose and pectin, which can limit the release of volatile oils. Cellulase and pectinase can specifically decompose cellulose and pectin in the cell wall, making the cell wall structure loose, thereby increasing the channel for volatile oils to be released from the cell into the surrounding solvent, improving the extraction rate of volatile oils, and releasing more volatile oils. Enzymatic hydrolysis can decompose some impurities such as cell wall fragments that may be extracted with volatile oils during the extraction process, which can improve the purity of volatile oils and reduce the impact of impurities on the quality of volatile oils. Enzymatic hydrolysis under appropriate temperature and pH conditions can avoid chemical changes in volatile oil components caused by overly drastic extraction conditions. Some volatile oil components will decompose and become ineffective under extreme high temperatures, while the enzymatic hydrolysis process is relatively mild, which helps to maintain the stability of volatile oil components during dissolution.

[0038] Traditional volatile oil extraction methods require a long soaking time to achieve a good extraction effect. After adding the enzymatic hydrolysis step, the volatile oil can be released faster because the cell wall is destroyed, thus shortening the overall extraction time and improving production efficiency. The enzymatic hydrolysis process is carried out under relatively mild temperature and pH conditions. Compared with some traditional extraction methods that require higher temperatures or more extreme pH conditions, this mild condition has relatively low requirements on equipment, while also reducing energy consumption and environmental impact, thereby optimizing extraction conditions.

[0039] Preferably, in the preparation of the medicinal powder in step S4, the preparation method of the roasted ephedra medicinal powder is: placing the roasted ephedra in a drying device, drying it in an electric blast drying oven at 40-60°C for 12-24 hours, coarsely crushing the dried roasted ephedra in a traditional Chinese medicine crusher, pulverizing it at 1000-2000 rpm for 1-3 minutes, and then placing it in a universal grinder for fine grinding, pulverizing it at 3000-5000 rpm for 5-10 minutes, and then passing it through an 80-100 mesh sieve; the preparation method of the wormwood powder is: placing the wormwood in a drying device, drying it in an electric blast drying oven at 40-60°C for 10-20 hours, coarsely crushing the dried wormwood in a traditional Chinese medicine crusher, pulverizing it at 1000-2000 rpm for 1-3 minutes, and then placing it in a universal grinder for fine grinding, pulverizing it at 2000-4000 rpm for 5-10 minutes, and then passing it through a 60-80 mesh sieve.

[0040] Making roasted ephedra and wormwood into powder can maintain their original efficacy, and when mixed and concentrated to make ointment, the powder can be better mixed with other extracted active ingredients to jointly exert the effect of relieving cough. Mixing and concentrating the above-mentioned extracted active ingredients and powder to make ointment can make the product more uniform and the active ingredients more concentrated, thereby improving the cough relieving effect of the product.

[0041] During the production of powder, when drying in an electric blast drying oven, maintaining 40-60°C can not only ensure that the active ingredients are not destroyed, but also effectively remove moisture. Too high a temperature will not only destroy the active ingredients, but also easily cause local overheating.

[0042] During the powder production process, the crushing time and speed are controlled to avoid excessive crushing. Excessive crushing may generate too much heat, causing the effective ingredients of the roasted ephedra powder to change and preventing ephedrine and other ingredients from decomposing at high temperatures. At the same time, excessive crushing will also cause the particles of the roasted ephedra powder and the wormwood powder to be too fine, increase electrostatic adsorption, make the powder easy to agglomerate, and affect subsequent mixing and other operations. The speed of the coarse crushing stage is controlled at 1000-2000 rpm, which can effectively crush the larger pieces of roasted ephedra medicinal materials and wormwood medicinal materials into smaller particles and avoid the entanglement of wormwood, and at the same time, the medicinal materials will not be over-crushed or generate too much heat due to excessive speed. The speed of 3000-5000 rpm for crushing roasted ephedra powder and 2000-4000 rpm for crushing wormwood powder in the fine crushing stage helps to further crush the coarsely crushed particles into finer powders, and the time is controlled at 5-10 minutes to avoid the heat generated by the machine affecting the quality of the roasted ephedra powder due to the long crushing time.

[0043] Preferably, in the step S5 mixing and concentration method, the amount of glycyrrhizic acid added to the licorice extract is 0.5-3% based on the total weight of the above-mentioned Chinese medicine dressing formula, and glycyrrhizic acid is gradually added during the stirring process, and stirring is continued for 15-30 minutes.

[0044] Licorice is a commonly used Chinese herbal medicine for harmonizing various medicines. It has many functions such as tonifying the spleen and replenishing qi, clearing away heat and detoxifying, and removing phlegm and relieving cough. From the perspective of detoxification, the glycyrrhizic acid and other ingredients contained in licorice can absorb poisons. The glycyrrhizic acid in licorice extract has a strong detoxification effect. By combining with some toxin components in the body, it reduces the absorption of toxic substances and can antagonize the toxic effects of drugs to a certain extent. In the process of making Chinese medicine dressings, after the other Chinese medicine ingredients are mixed in a predetermined ratio, the licorice extract is gradually and slowly added during the stirring process, and the stirring is continued for 15-30 minutes to ensure that it is evenly distributed throughout the dressing.

[0045] The present invention provides a Chinese medicine patch product with cough relieving effect, which is comprehensive and suitable for treating cough caused by various reasons. Roasted ephedra has the effects of sweating and relieving exterior symptoms, ventilating the lungs and relieving asthma; coltsfoot flower can moisten the lungs and lower the qi, relieve cough and resolve phlegm; salvia miltiorrhiza can promote blood circulation and remove blood stasis, promote menstruation and relieve pain; perilla leaf can relieve exterior symptoms and dispel cold, promote qi and relieve fullness; corydalis has the effects of promoting blood circulation, promoting qi and relieving pain; white mustard can warm the lungs and dispel phlegm, promote qi and relieve stagnation; radix stemonae can moisten the lungs and relieve cough, kill insects and kill lice; pinellia can dry dampness and resolve phlegm, reduce adverse reactions and stop vomiting; scutellaria baicalensis can clear away heat and dry dampness, purge fire and detoxify; aster can moisten the lungs and lower the qi, relieve cough and resolve phlegm; asarum can dispel wind and dissipate cold, open the orifices and relieve pain, warm the lungs and resolve fluid; houttuynia cordata can clear away heat and detoxify, eliminate carbuncle and discharge pus, promote diuresis and relieve stranguria; schizonepeta can relieve exterior symptoms and dissipate wind, clear rash and eliminate sores; wormwood can warm the meridians and dissipate cold, regulate menstruation and relieve pain, and stabilize pregnancy. These medicinal materials are compatible with each other and work synergistically to jointly exert the effect of relieving cough and provide comprehensive conditioning. They are suitable for coughs caused by various reasons.

[0046] In summary, the present invention has the following beneficial effects: 1. The Chinese medicine formula is derived from the acupuncture point application therapy of Luo's secret recipe for relieving cough, clearing lungs and resolving phlegm. It does not require oral administration. After scientific research and technological innovation, the formula has been optimized, and the raw materials that strongly irritate the skin in the original formula have been removed. The basic causes such as cold and dampness damaging the lungs, wind evil invasion, and complications such as depression and heat, blood stasis, and phlegm caused by cold and dampness have been comprehensively considered. The present invention provides a Chinese medicine application product with cough relieving effect, which is comprehensive and suitable for treating coughs caused by various reasons; 2. The preparation method of the Chinese medicine patch product provided by the present invention designs different extraction process flows according to the characteristics of each Chinese medicine, obtains the effective ingredients to the maximum extent, and finally mixes and concentrates them to make ointments. The side effects caused by impurities are avoided by purifying the Chinese medicine, the content of effective substances is increased, and the high permeability of small molecule extracts is ensured, so that the effect is better. The countercurrent extraction system is adopted in the alcohol extraction method, the microfiltration membrane and the ultrafiltration membrane are used for separation in the water extraction and alcohol precipitation method, and the enzymatic hydrolysis and soaking process of the composite enzyme of cellulase and pectinase is added to the volatile oil extraction method, so as to improve the extraction process flow, which is different from the traditional process, has better extraction effect, higher efficiency, and is safer, energy-saving and environmentally friendly. 3. After the active ingredients extracted in the preparation method of the present invention are mixed with the powder, an appropriate amount of licorice extract is added, stirred evenly and concentrated to form an ointment. The toxicity is alleviated by adding glycyrrhizic acid, and the cough suppressant effect is improved at the same time; 4. The present invention provides a new type of Chinese medicine patch product with antitussive effect. The drug is administered by acupuncture point application without oral administration, thus avoiding the addiction and toxicity of existing oral cough suppressants and the harm caused by side effects such as nausea, vomiting, dizziness, etc. DETAILED DESCRIPTION

[0047] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

[0048] Example 1

[0049] The composition and dosage ratio of the Chinese medicine patch dressing product include: 12.8 parts of roasted ephedra, 4.8 parts of coltsfoot flower, 4.8 parts of salvia miltiorrhiza, 4.8 parts of perilla leaves, 4.8 parts of Corydalis yanhusuo, 4.8 parts of white mustard seeds, 6.4 parts of Stemona, 6.4 parts of Pinellia, 4.8 parts of Scutellaria, 4.8 parts of Aster, 9.6 parts of Asarum, 6.4 parts of Houttuynia cordata, 4.8 parts of Schizonepeta, and 20 parts of Artemisia argyi.

[0050] S1 alcohol extraction: extract the effective ingredients from coltsfoot flower, salvia miltiorrhiza and perilla leaf by alcohol extraction method, the alcohol extraction method adopts countercurrent extraction system: add 70% ethanol, the solid-liquid ratio is 1:12g / ml, the extraction temperature is 60°C, the extraction time is 3 hours, the medicinal material feed flow rate is set to 2kg / h, and the solvent feed flow rate is set to 4kg / h; S2 water extraction and alcohol precipitation: extract the effective ingredients from Rhizoma Corydalis, Semen Sinapis, Radix Stemonae, Rhizoma Pinelliae, Radix Scutellariae, and Rhizoma Asteris by water extraction and alcohol precipitation, wherein the water extraction and alcohol precipitation method is to first boil them in water for 2 hours, the amount of water used is 10 times the weight of the medicinal materials, filter the filtrate, separate them by microfiltration membrane and ultrafiltration membrane, and then precipitate the filtrate by alcohol, the amount of ethanol used during the alcohol precipitation is 2.5 times the volume of the filtrate; the microfiltration membrane is selected with a pore size of 0.5μm and a transmembrane pressure of 0.3MPa; the ultrafiltration membrane is selected with a molecular weight cutoff of 50kDa, a transmembrane pressure of 0.5MPa, and a membrane flux of 50L / (m²・h); S3 volatile oil extraction: extract the active ingredients from Asarum, Houttuynia cordata and Nepeta tenuifolia by a volatile oil extraction method, wherein the volatile oil extraction method comprises adding 10 times the weight of the medicinal materials with water and 1.0% of the weight of the medicinal materials with a complex enzyme of cellulase and pectinase, adjusting the pH to 5.0 with a citric acid-sodium citrate buffer solution, and performing enzymolysis and soaking at 40°C for 3 hours before steam distillation; S4 preparation of medicinal powder: preparing medicinal powder from roasted ephedra and wormwood leaf, wherein the preparation method of roasted ephedra medicinal powder is as follows: placing roasted ephedra in a drying device, drying in an electric blast drying oven at 50°C for 18 hours, coarsely crushing the dried roasted ephedra in a traditional Chinese medicine crusher, pulverizing at 1500 rpm for 2 minutes, and then placing in a universal grinder for fine pulverization, pulverizing at 4000 rpm for 7 minutes, and then passing through a 90-mesh sieve; the preparation method of wormwood leaf medicinal powder is as follows: placing wormwood leaf in a drying device, drying in an electric blast drying oven at 50°C for 15 hours, coarsely crushing the dried wormwood leaf in a traditional Chinese medicine crusher, pulverizing at 15000 rpm for 2 minutes, and then placing in a universal grinder for fine pulverization, pulverizing at 3000 rpm for 7 minutes, and then passing through a 70-mesh sieve; S5 Mixing and concentration: Mix the above-extracted active ingredients and powder, add licorice extract, and calculate based on the total weight of the above-mentioned Chinese medicine dressing formula that the amount of glycyrrhizic acid added to the licorice extract is 2%. Gradually add glycyrrhizic acid during stirring, and continue stirring for 20 minutes. After continuous stirring and mixing evenly, concentrate to make an ointment.

[0051] Example 2

[0052] The composition and dosage ratio of the Chinese medicine patch dressing product include: 10 parts of roasted ephedra, 2 parts of coltsfoot flower, 2 parts of salvia miltiorrhiza, 2 parts of perilla leaves, 2 parts of Corydalis yanhusuo, 2 parts of white mustard seeds, 4 parts of Stemona, 4 parts of Pinellia, 4 parts of Scutellaria, 4 parts of Aster, 5 parts of Asarum, 4 parts of Houttuynia cordata, 2 parts of Schizonepeta, and 15 parts of Artemisia argyi.

[0053] S1 alcohol extraction: extracting effective ingredients from coltsfoot flower, salvia miltiorrhiza and perilla leaf by alcohol extraction method, wherein the alcohol extraction method adopts countercurrent extraction system: adding 60% ethanol, the solid-liquid ratio is 1:15g / ml, the extraction temperature is 50°C, the extraction time is 2 hours, the medicinal material feed flow rate is set to 1kg / h, and the solvent feed flow rate is set to 3kg / h; S2 water extraction and alcohol precipitation: extract the effective ingredients from Rhizoma Corydalis, Semen Sinapis, Radix Stemonae, Rhizoma Pinelliae, Radix Scutellariae, and Rhizoma Asteris by water extraction and alcohol precipitation, wherein the water extraction and alcohol precipitation method is to first decoct in water for 1.5 hours, the amount of water used is 8 times the weight of the medicinal materials, filter to obtain the filtrate, separate by microfiltration membrane and ultrafiltration membrane, and then perform alcohol precipitation on the filtrate, the amount of ethanol used during alcohol precipitation is 2 times the volume of the filtrate; the microfiltration membrane is selected with a pore size of 0.1μm and a transmembrane pressure of 0.1MPa; the ultrafiltration membrane is selected with a molecular weight cutoff of 10kDa, a transmembrane pressure of 0.2MPa, and a membrane flux of 10L / (m²・h); S3 volatile oil extraction: extract the active ingredients from Asarum, Houttuynia cordata and Nepeta tenuifolia by a volatile oil extraction method, wherein water 8 times the weight of the medicinal materials and 0.2% of the weight of the medicinal materials are added to a complex enzyme of cellulase and pectinase, the pH is adjusted to 4.0 with a citric acid-sodium citrate buffer solution, and the enzymatic hydrolysis is soaked at 30°C for 2 hours before steam distillation; S4 preparation of medicinal powder: preparing medicinal powder from roasted ephedra and wormwood leaf, wherein the preparation method of roasted ephedra medicinal powder is as follows: placing roasted ephedra in a drying device, drying in an electric blast drying oven at 40°C for 12 hours, coarsely crushing the dried roasted ephedra in a traditional Chinese medicine crusher, pulverizing at 1000 rpm for 1 minute, and then placing in a universal grinder for fine pulverization, pulverizing at 3000 rpm for 5 minutes, and then passing through an 80-mesh sieve; the preparation method of wormwood leaf powder is as follows: placing wormwood leaf in a drying device, drying in an electric blast drying oven at 40°C for 10 hours, coarsely crushing the dried wormwood leaf in a traditional Chinese medicine crusher, pulverizing at 1000 rpm for 1 minute, and then placing in a universal grinder for fine pulverization, pulverizing at 2000 rpm for 5 minutes, and then passing through a 60-mesh sieve; S5 Mixing and concentration: Mix the above-extracted active ingredients and powder, add licorice extract, and calculate based on the total weight of the above-mentioned Chinese medicine dressing formula that the amount of glycyrrhizic acid added to the licorice extract is 0.5%. Gradually add glycyrrhizic acid during stirring, and continue stirring for 15 minutes. After continuous stirring and mixing evenly, concentrate to make an ointment.

[0054] Example 3

[0055] The composition and dosage ratio of the Chinese medicine patch dressing product include: 15 parts of roasted ephedra, 6 parts of coltsfoot flower, 6 parts of salvia miltiorrhiza, 6 parts of perilla leaves, 6 parts of Corydalis yanhusuo, 6 parts of white mustard seeds, 8 parts of Stemona, 8 parts of Pinellia, 8 parts of Scutellaria, 8 parts of Aster, 10 parts of Asarum, 8 parts of Houttuynia cordata, 6 parts of Schizonepeta, and 30 parts of Artemisia argyi.

[0056] S1 alcohol extraction: extracting effective ingredients from coltsfoot flower, salvia miltiorrhiza and perilla leaf by alcohol extraction method, the alcohol extraction method adopts countercurrent extraction system: adding ethanol with a concentration of 85%, a solid-liquid ratio of 1:10g / ml, an extraction temperature of 70°C, an extraction time of 4 hours, setting the medicinal material feed flow rate to 3kg / h, and the solvent feed flow rate to 6kg / h; S2 water extraction and alcohol precipitation: extract the effective ingredients from Rhizoma Corydalis, Semen Sinapis, Radix Stemonae, Rhizoma Pinelliae, Radix Scutellariae, and Rhizoma Asteris by water extraction and alcohol precipitation, wherein the water is first decocted for 3 hours, the amount of water used is 12 times the weight of the medicinal materials, the filtrate is filtered, separated by microfiltration membrane and ultrafiltration membrane, and then the filtrate is subjected to alcohol precipitation treatment, the amount of ethanol used during alcohol precipitation is 5 times the volume of the filtrate; the microfiltration membrane is selected with a pore size of 1μm and a transmembrane pressure of 0.5MPa; the ultrafiltration membrane is selected with a molecular weight cutoff of 100kDa, a transmembrane pressure of 1MPa, and a membrane flux of 100L / (m²・h); S3 volatile oil extraction: extract the active ingredients from Asarum, Houttuynia cordata and Nepeta tenuifolia by a volatile oil extraction method, wherein the volatile oil extraction method comprises adding 12 times the weight of the medicinal materials with water and 2.0% of the weight of the medicinal materials with a complex enzyme of cellulase and pectinase, adjusting the pH to 5.5 with a citric acid-sodium citrate buffer solution, and performing enzymolysis and soaking at 50°C for 4 hours before steam distillation; S4 preparation of medicinal powder: preparing medicinal powder from roasted ephedra and wormwood leaf, wherein the preparation method of roasted ephedra medicinal powder is as follows: placing roasted ephedra in a drying device, drying in an electric blast drying oven at 60°C for 24 hours, coarsely crushing the dried roasted ephedra in a traditional Chinese medicine crusher, pulverizing at 2000 rpm for 3 minutes, and then placing in a universal grinder for fine pulverization, pulverizing at 5000 rpm for 10 minutes, and then passing through a 100-mesh sieve; the preparation method of wormwood leaf medicinal powder is as follows: placing wormwood leaf in a drying device, drying in an electric blast drying oven at 60°C for 20 hours, coarsely crushing the dried wormwood leaf in a traditional Chinese medicine crusher, pulverizing at 2000 rpm for 3 minutes, and then placing in a universal grinder for fine pulverization, pulverizing at 4000 rpm for 10 minutes, and then passing through a 60-80 mesh sieve; S5 Mixing and concentration: Mix the above-extracted active ingredients and powder, add licorice extract, and calculate based on the total weight of the above-mentioned Chinese medicine dressing formula that the amount of glycyrrhizic acid added to the licorice extract is 3%. Gradually add glycyrrhizic acid during stirring, and continue stirring for 30 minutes. After continuous stirring and mixing evenly, concentrate to make an ointment.

[0057] Example 4

[0058] The composition and dosage ratio of the Chinese medicine patch dressing product include: 10 parts of roasted ephedra, 2 parts of coltsfoot flower, 2 parts of salvia miltiorrhiza, 2 parts of perilla leaves, 2 parts of Corydalis yanhusuo, 2 parts of white mustard seeds, 4 parts of Stemona, 4 parts of Pinellia, 4 parts of Scutellaria, 4 parts of Aster, 5 parts of Asarum, 4 parts of Houttuynia cordata, 2 parts of Schizonepeta, and 15 parts of Artemisia argyi.

[0059] S1 alcohol extraction: extracting effective ingredients from coltsfoot flower, salvia miltiorrhiza and perilla leaf by alcohol extraction method, the alcohol extraction method adopts countercurrent extraction system: adding ethanol with a concentration of 85%, a solid-liquid ratio of 1:10g / ml, an extraction temperature of 70°C, an extraction time of 4 hours, setting the medicinal material feed flow rate to 3kg / h, and the solvent feed flow rate to 6kg / h; S2 water extraction and alcohol precipitation: extract the effective ingredients from Rhizoma Corydalis, Semen Sinapis, Radix Stemonae, Rhizoma Pinelliae, Radix Scutellariae, and Rhizoma Asteris by water extraction and alcohol precipitation, wherein the water is first decocted for 3 hours, the amount of water used is 12 times the weight of the medicinal materials, the filtrate is filtered, separated by microfiltration membrane and ultrafiltration membrane, and then the filtrate is subjected to alcohol precipitation treatment, the amount of ethanol used during alcohol precipitation is 5 times the volume of the filtrate; the microfiltration membrane is selected with a pore size of 1μm and a transmembrane pressure of 0.5MPa; the ultrafiltration membrane is selected with a molecular weight cutoff of 100kDa, a transmembrane pressure of 1MPa, and a membrane flux of 100L / (m²・h); S3 volatile oil extraction: extract the active ingredients from Asarum, Houttuynia cordata and Nepeta tenuifolia by a volatile oil extraction method, wherein the volatile oil extraction method comprises adding 12 times the weight of the medicinal materials with water and 2.0% of the weight of the medicinal materials with a complex enzyme of cellulase and pectinase, adjusting the pH to 5.5 with a citric acid-sodium citrate buffer solution, and performing enzymolysis and soaking at 50°C for 4 hours before steam distillation; S4 preparation of medicinal powder: preparing medicinal powder from roasted ephedra and wormwood leaf, wherein the preparation method of roasted ephedra medicinal powder is as follows: placing roasted ephedra in a drying device, drying in an electric blast drying oven at 60°C for 24 hours, coarsely crushing the dried roasted ephedra in a traditional Chinese medicine crusher, pulverizing at 2000 rpm for 3 minutes, and then placing in a universal grinder for fine pulverization, pulverizing at 5000 rpm for 10 minutes, and then passing through a 100-mesh sieve; the preparation method of wormwood leaf medicinal powder is as follows: placing wormwood leaf in a drying device, drying in an electric blast drying oven at 60°C for 20 hours, coarsely crushing the dried wormwood leaf in a traditional Chinese medicine crusher, pulverizing at 2000 rpm for 3 minutes, and then placing in a universal grinder for fine pulverization, pulverizing at 4000 rpm for 10 minutes, and then passing through a 60-80 mesh sieve; S5 Mixing and concentration: Mix the above-extracted active ingredients and powder, add licorice extract, and calculate based on the total weight of the above-mentioned Chinese medicine dressing formula that the amount of glycyrrhizic acid added to the licorice extract is 3%. Gradually add glycyrrhizic acid during stirring, and continue stirring for 30 minutes. After continuous stirring and mixing evenly, concentrate to make an ointment.

[0060] Comparative Example 1 The main raw materials of the commercially available compound licorice tablets (Sinopharm Group Industrial Co., Ltd., approval number: H11020671) include: licorice extract powder, opium powder, camphor, star anise oil, and sodium benzoate.

[0061] Comparative Example 2 The commercially available Kyoto Ninjiom Chuanbei Loquat Paste (Kyoto Ninjiom Co., Ltd., approval number: National Medicine Standard ZC20160005) has the following main ingredients: Fritillaria cirrhosa, loquat leaf, Adenophora australis, Poria, Citrus aurantium, Platycodon grandiflorum, Pinellia ternata, Schisandra chinensis, Trichosanthes fruit, Coltsfoot flower, Polygala tenuifolia, bitter almond, ginger, licorice, almond water, and menthol.

[0062] The main ingredient of commercially available ketotifen (Jinghua Pharmaceutical Group Co., Ltd., approval number: National Medicine Standard H32023509) is: ketotifen fumarate.

[0063] Comparative Example 3 The main raw materials of the commercially available Yumei Granules (Nanjing Chengong Pharmaceutical Co., Ltd., approval number: National Medicine Standard H19990040) are: dextromethorphan hydrobromide and guaifenesin glyceryl ether.

[0064] Raw materials for Chinese herbal patch: 10g of Rehmannia root, 10g of Ophiopogon japonicus, 10g of Schisandra chinensis, 6g of Ginseng, and 10g of Saposhnikovia divaricata are ground into powder. Each dose of the decoction pieces is made into 45g of powder and divided into 9 bags, 5g / bag.

[0065] Comparative Example 4 Raw materials for Chinese herbal patch: roasted ephedra 12.8g, coltsfoot flower 4.8g, salvia miltiorrhiza 4.8g, perilla leaf 4.8g, Corydalis 4.8g, white mustard seed 4.8g, Stemona 6.4g, Pinellia 6.4g, Scutellaria 4.8g, Aster 4.8g, Asarum 9.6g, Houttuynia cordata 6.4g, Schizonepeta tenuifolia 4.8g, and Artemisia argyi 20g are ground into powder. Each dose of the decoction pieces is made into 45g of powder and divided into 9 bags, 5g / bag.

[0066] 1. Experimental Methods 400 subjects who volunteered to receive treatment were screened, all of whom were cough patients. All subjects were clearly diagnosed and had relevant clinical manifestations (sore throat, nasal congestion, sneezing, fever, etc.). Patients were first given conventional drug treatment, and those whose condition did not improve after a period of time still had cough symptoms. X-ray chest films and blood routine tests were normal, and patients with cough variant asthma, bronchial asthma, gastroesophageal reflux and other diseases, as well as breastfeeding or pregnant women, and those with heart, lung, and liver dysfunction were excluded.

[0067] The severity of the patient's cough was scored, and the cough scoring standard was a point system: ①0 points: no cough; ②1 point: occasional cough; ③2 points: frequent cough; ④3 points: frequent cough, affecting daily life. The efficacy evaluation standard was formulated with reference to the "Guidelines for Clinical Research of New Chinese Medicines". Cough score improvement rate = (cough score before treatment - cough score after treatment) / cough score before treatment × 100%. After one week of continuous treatment, the cough efficacy of the patient was evaluated. The effect evaluation criteria are shown in Table 1.

[0068] Table 1 Evaluation criteria for cough suppressant efficacy

[0069] 2. Experimental results The subjects were randomly divided into 8 groups, each with 50 people. Groups 1-4 were Example groups, and the ointments prepared in Examples 1-4 were used as Chinese medicine patch products to directly apply to the Tiantu and Tanzhong acupoints, once a day, 4 hours each time, for 7 consecutive days. The other 4 groups were control groups: patients in control group 1 were treated with compound licorice tablets in control group 1, orally, 3 times a day, 3 tablets each time, for 7 consecutive days; patients in control group 2 were treated with Kyoto Nissin Jiom Chuanbei Loquat Paste in control group 2, orally, 3 times a day, 1 tablespoon about 15 mL each time, and ketotifen was given at the same time, 1 mg orally before going to bed, once a day, for 7 consecutive days; patients in control group 3 were treated with Yumei Granules in control group 3, orally, 3 times a day, 2 bags each time, and the powder prepared in control group 3 was mixed with warm water and applied to Tiantu and Tanzhong acupoints, once a day, 4 hours each time, for 7 consecutive days; patients in control group 4 were treated with powder prepared in control group 4, mixed with warm water and applied to Tiantu and Tanzhong acupoints, once a day, 4 hours each time, for 7 consecutive days. After one week of continuous treatment, the antitussive effect of the patients was evaluated, as shown in Table 2.

[0070] Table 2 Antitussive effect (unit: case)

[0071] 3. Results Analysis From the experimental results, it can be seen that the number of cured patients in Examples 1-4 is 14, indicating that the Chinese medicine patch product prepared by the present invention has a high success rate in promoting complete recovery of patients, and the effect is relatively stable; in the comparative example groups, the number of cured patients in Comparative Example 1 is 9, which is relatively small; the number of cured patients in Comparative Example 2 is 11; the number of cured patients in Comparative Example 3 is 10; the number of cured patients in Comparative Example 4 is 12; the number of cured patients in the comparative example groups is generally lower than that in the embodiment groups, indicating that the effects of these treatment methods in promoting complete recovery of patients are relatively weak.

[0072] The number of effective people in Examples 1-4 is 18-19, indicating that the ointment is more prominent in significantly improving cough symptoms; in the comparative group, the number of effective people in Comparative Example 1 is 16; Comparative Example 2 is 16; Comparative Example 3 is 17; Comparative Example 4 is 17; the number of effective people in the comparative group is not much different from that in the embodiment group, but considering the total sample size, its effective rate is relatively lower than that in the embodiment group. The number of people who improved in Examples 1-4 is between 15-17, which further reflects that the product has a relatively wide effect on relieving cough symptoms. The number of invalid people in Example 1 is 0, and the number of invalid people in Examples 2, 3, and 4 is relatively small, namely 3, 1, and 2, respectively, indicating that the number of invalid people in the embodiment group is relatively small; in the comparative group, the number of invalid people in Comparative Example 1 is 13, which is relatively large; Comparative Example 2 is 7; Comparative Example 3 is 11; Comparative Example 4 is 5; the number of invalid people in the comparative group is higher than that in the embodiment group as a whole, which shows that the total effective rate of the Chinese medicine patch product is extremely high and the therapeutic effect on cough is significant.

[0073] From the cough-relieving efficacy results, it can be seen that the total effective rates of the groups of Examples 1-4 of the present invention are higher than those of the groups of Comparative Examples 1-4, with Example 1 being as high as 100%, and Examples 2, 3, and 4 also reaching 94.00%, 98.00%, and 96.00%, respectively, which indicates that the secret ointment Chinese medicine patch products of the Example groups are effective in the overall treatment of cough; while the total effective rates of the Comparative Example groups are relatively low, with Comparative Example 1 being 74.00%, Comparative Example 2 being 86.00%, Comparative Example 3 being 78.00%, and Comparative Example 4 being 90.00%. Although the total effective rate of Comparative Example 4 is relatively high, it is still lower than that of Example 1; Comparative Example 1 adopts oral treatment with compound licorice tablets, which has a certain effect, but the total effective rate is relatively low, indicating that the compound licorice tablets are not highly targeted for the cough symptoms of some patients; In comparative example 2, the total effective rate was improved by taking Kyoto Nisjiom Chuanbei Loquat Paste orally and combining it with ketotifen for treatment, which showed that the combined medication could enhance the therapeutic effect, but it was still not as good as that in the example group; in comparative example 3, Yumei Granules were taken orally and combined with homemade powder for acupoint application, which combined the methods of oral medication and acupoint application, but the effect was still not as good as that in the example group, indicating that the efficacy of Yumei Granules and the formula and application effect of homemade powder were not as good as those of the ointment in the example group; in comparative example 4, only homemade powder was used for acupoint application, and the total effective rate was higher, but there was still a gap compared with example 1, indicating that homemade powder had a certain effect in acupoint application, but further improvement was needed in the formula and production process. The preparation method of the Chinese medicine patch product provided by the present invention can more effectively exert the effect of the effective ingredients and improve cough symptoms.

Claims

1. A Chinese medicine patch product with antitussive effect, characterized in that: The raw materials of Chinese herbal dressing products include: 10-15 parts of roasted ephedra, 2-6 parts of coltsfoot flower, 2-6 parts of salvia miltiorrhiza, 2-6 parts of perilla leaves, 2-6 parts of Corydalis yanhusuo, 2-6 parts of white mustard seeds, 4-8 parts of Stemona, 4-8 parts of Pinellia, 4-8 parts of Scutellaria, 4-8 parts of Aster, 5-10 parts of Asarum, 4-8 parts of Houttuynia cordata, 2-6 parts of Schizonepeta, and 15-30 parts of Artemisia argyi.

2. A Chinese medicine patch product with antitussive effect according to claim 1, characterized in that: The composition and dosage ratio of the Chinese medicine patch dressing product include: 11-14 parts of roasted ephedra, 3-5 parts of coltsfoot flower, 3-5 parts of salvia miltiorrhiza, 3-5 parts of perilla leaves, 3-5 parts of Corydalis yanhusuo, 3-5 parts of white mustard seeds, 5-7 parts of Stemona, 5-7 parts of Pinellia, 5-7 parts of Scutellaria, 5-7 parts of Aster, 6-9 parts of Asarum, 5-7 parts of Houttuynia cordata, 3-5 parts of Schizonepeta, and 14-26 parts of Artemisia argyi.

3. A Chinese medicine patch product with antitussive effect according to claim 1, characterized in that: The preparation method of the Chinese medicine patch product comprises the following steps: S1 alcohol extraction: extracting effective ingredients from coltsfoot flower, salvia miltiorrhiza and perilla leaf by alcohol extraction method, wherein the alcohol extraction method comprises: using a countercurrent extraction system, adding ethanol with a volume concentration of 60-85%, a solid-liquid ratio of 1:10-15 g / ml, an extraction temperature of 50-70°C, and an extraction time of 2-4 hours; S2 water extraction and alcohol precipitation: extracting effective ingredients from Corydalis yanhusuo, white mustard seeds, Stemona tuber, Pinellia ternata, Scutellaria baicalensis, and Aster radix by water extraction and alcohol precipitation, wherein the water extraction and alcohol precipitation method is to first decoct in water for 1.5-3 hours, the amount of water used is 8-12 times the weight of the medicinal materials, filter to obtain a filtrate, and then perform alcohol precipitation on the filtrate, and the amount of ethanol used during the alcohol precipitation is 2-5 times the volume of the filtrate; S3 volatile oil extraction: extracting effective ingredients from Asarum, Houttuynia cordata and Nepeta tenuifolia by a volatile oil extraction method, wherein the volatile oil extraction method comprises adding water 8-12 times the weight of the medicinal materials, soaking for 2-4 hours and then performing steam distillation; S4 Preparation of medicinal powder: preparing medicinal powder by roasting ephedra and wormwood leaves; S5 Mixing and concentration: Mix the above-extracted active ingredients and powder, add licorice extract, stir and mix continuously until evenly mixed, and then concentrate to make an ointment.

4. A Chinese medicine patch product with antitussive effect according to claim 3, characterized in that: The alcohol extraction method in step S1 adopts a countercurrent extraction system: adding ethanol with a concentration of 65-80%, a solid-liquid ratio of 1:11-14g / ml, an extraction temperature of 55-65°C, and an extraction time of 3-4 hours; The specific operation of the countercurrent extraction system is as follows: slowly adding the pretreated medicinal materials from the medicinal material feed port of the countercurrent extractor, and adding the prepared ethanol solution from the solvent feed port at a certain flow rate, setting the medicinal material feed flow rate to 1-3kg / h, and the solvent feed flow rate to 3-6kg / h; setting the temperature of the countercurrent extractor to 55-65°C, controlling the countercurrent extraction time to 3-4 hours, and after the extraction is completed, the extract flows out from the extract discharge port, and the extract is collected for subsequent processing.

5. A Chinese medicine patch product with antitussive effect according to claim 3, characterized in that: The water extraction and alcohol precipitation method in step S2 is: first add water and boil for 2-3 hours, the amount of water used is 9-11 times the weight of the medicinal material, filter to obtain a filtrate, separate it using a microfiltration membrane and an ultrafiltration membrane, and then perform alcohol precipitation on the filtrate, the amount of ethanol used during alcohol precipitation is 2-3 times the volume of the filtrate; the microfiltration membrane is selected with a pore size of 0.1-1μm, and the transmembrane pressure is set at 0.1-0.5MPa; the ultrafiltration membrane is selected with a molecular weight cutoff of 10-100kDa, a transmembrane pressure of 0.2-1MPa, and a membrane flux of 10-100L / (m²・h).

6. A Chinese medicine patch product with antitussive effect according to claim 3, characterized in that: The volatile oil extraction method in step S3 is as follows: adding 9-11 times of the weight of the medicinal material with water and 0.2%-2.0% of the weight of the medicinal material with a complex enzyme of cellulase and pectinase, adjusting the pH to 4.0-5.5 with a citric acid-sodium citrate buffer solution, enzymolysis and soaking at 30-50° C. for 3-4 hours, and then performing steam distillation.

7. A Chinese medicine patch product with antitussive effect according to claim 3, characterized in that: In the step S4 of preparing the medicinal powder, the preparation method of the roasted ephedra medicinal powder is as follows: the roasted ephedra is placed in a drying device, dried in an electric blast drying oven at 40-60° C. for 12-24 hours, the dried roasted ephedra is coarsely crushed in a traditional Chinese medicine crusher, crushed at 1000-2000 rpm for 1-3 minutes, and then placed in a universal grinder for fine crushing, crushed at 3000-5000 rpm for 5-10 minutes, and then passed through an 80-100 mesh sieve; the preparation method of the wormwood leaf powder is as follows: the wormwood leaf is placed in a drying device, dried in an electric blast drying oven at 40-60° C. for 10-20 hours, the dried wormwood leaf is coarsely crushed in a traditional Chinese medicine crusher, crushed at 1000-2000 rpm for 1-3 minutes, and then placed in a universal grinder for fine crushing, crushed at 2000-4000 rpm for 5-10 minutes, and then passed through a 60-80 mesh sieve.

8. A Chinese medicine patch product with antitussive effect according to claim 3, characterized in that: In the step S5 mixing and concentration method, the amount of glycyrrhizic acid added to the licorice extract is 0.5-3.0% based on the total weight of the above-mentioned Chinese medicine dressing formula. Glycyrrhizic acid is gradually added during the stirring process and stirring is continued for 15-30 minutes.

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