Traditional Chinese medicine hair growth composition and external hair growth liquid and preparation method thereof

Abstract

The invention relates to the field of cosmetics, and particularly provides a traditional Chinese medicine hair-growing composition and an external hair-growing liquid and a preparation method thereof, the traditional Chinese medicine hair-growing composition comprises cortex phellodendri, raw rhubarb, raw cacumen biotae, turmeric and white willow bark, and the external hair-growing liquid is prepared by extracting the traditional Chinese medicine hair-growing composition through a water extraction and alcohol precipitation method and then adding proper pharmaceutic adjuvants. The traditional Chinese medicine hair-growing composition has a good treatment effect on alopecia in green and middle-aged years, and has the characteristics of hair growth and development, oil removal and dandruff stopping, mildness and safety.

Description

Technical Field

[0001] The invention relates to the field of cosmetics, and in particular to a traditional Chinese medicine hair growth composition and an external hair growth liquid and a preparation method thereof. Background Art

[0002] In recent years, the problem of hair loss among young and middle-aged people has become increasingly prominent, and its incidence rate has shown a rising trend. The fast-paced life and huge work and study pressure in modern society have caused more and more young and middle-aged people to suffer from hair loss. For example, among young and middle-aged working people in some big cities, hair loss is no longer a rare phenomenon. A large amount of survey data shows that the incidence of hair loss among people aged 20-45 has increased year by year, and the growth rate has a tendency to accelerate.

[0003] Traditional Chinese medicine has unique advantages and rich methods in treating hair loss in young and middle-aged people. Currently, the commonly used traditional Chinese medicines that have an effect on hair growth include: Polygonum multiflorum, Platycladus orientalis, ginseng, etc. However, in recent years, the research on raw (processed) Polygonum multiflorum causing liver damage has continued to increase. Most studies believe that the material basis of raw Polygonum multiflorum and processed Polygonum multiflorum causing liver toxicity includes water extract, alcohol extract, diphenylethylene glycosides, anthraquinone compounds and gallic acid. The 2010 edition of the Chinese Pharmacopoeia adjusted the dosage of raw Polygonum multiflorum from 6 to 12g to 3 to 6g. Although it improves its safety, it also affects the normal clinical application of Polygonum multiflorum to a certain extent. External use has little effect on the human body. However, this does not mean that there is no risk at all when using Polygonum multiflorum in shampooing and hair care. In the case of long-term use, a small amount of harmful ingredients may be absorbed into the human body through the scalp. As a precious traditional Chinese medicine, ginseng is expensive, which makes it not widely used. In addition, ginseng contains a variety of chemical components, such as ginsenosides, polysaccharides, volatile oils, etc. When ginseng is used externally, these ingredients may cause allergic reactions in some people.

[0004] Therefore, it is extremely necessary to develop a green, mild, safe and reliable Chinese herbal hair growth composition that can be beneficial to hair loss in young and middle-aged people, and urgently address the unmet needs of clinical hair loss treatment. Summary of the invention

[0005] The purpose of the present invention is to overcome the above technical problems, provide a Chinese medicine hair growth composition and its external hair growth liquid and preparation method, for treating hair loss in young and middle-aged people. The external hair growth liquid prepared by the Chinese medicine hair growth composition can not only grow hair, remove oil and stop dandruff, but also achieve the effect of gentleness and safety for long-term use.

[0006] In a first aspect, the present invention provides a traditional Chinese medicine hair growth composition, which comprises the following components: phellodendron chinense, raw rhubarb, raw arborvitae leaves, turmeric, and white willow bark.

[0007] In some embodiments, the traditional Chinese medicine hair growth composition is composed of 50-150 parts of Phellodendron chinense, 30-60 parts of raw rhubarb, 250-350 parts of raw Platycladus orientalis leaves, 50-150 parts of turmeric, and 150-300 parts of white willow bark.

[0008] In some embodiments, the traditional Chinese medicine hair growth composition is composed of 100 parts of Phellodendron chinense, 50 parts of raw rhubarb, 300 parts of raw Platycladus orientalis leaves, 100 parts of turmeric, and 250 parts of white willow bark.

[0009] In some embodiments, the traditional Chinese medicine hair growth composition is composed of 50-150g of Phellodendron amurense, 30-60g of raw rhubarb, 250-350g of raw Platycladus orientalis leaves, 50-150g of turmeric, and 150-300g of white willow bark.

[0010] Preferably, 100g of Phellodendron chinense, 50g of raw rhubarb, 300g of raw Platycladus orientalis leaves, 100g of turmeric, and 250g of white willow bark.

[0011] In a second aspect, the present invention provides an external hair growth liquid, which is prepared from the above-mentioned traditional Chinese medicine hair growth composition and salicylic acid, benzoic acid and eucalyptol.

[0012] In some embodiments, the external hair growth liquid is prepared by preparing the Chinese medicine hair growth composition through water extraction and alcohol precipitation to obtain a Chinese medicine extract and salicylic acid, benzoic acid, and eucalyptol.

[0013] In some embodiments, 1-1.8% salicylic acid, 0.05-0.2% benzoic acid, and 0.05% eucalyptol are added to every 100 ml of the traditional Chinese medicine extract.

[0014] The third aspect of the present invention provides a method for preparing an external hair growth liquid, comprising the following steps:

[0015] (1) Weigh each component of the Chinese medicine composition and crush the Chinese medicine into coarse powder;

[0016] (2) Using water extraction and alcohol precipitation method to obtain the stock solution;

[0017] (3) distilling and diluting the stock solution to obtain a Chinese medicine extract;

[0018] (4) Add salicylic acid, benzoic acid and eucalyptol.

[0019] In some embodiments, the method for preparing the external hair growth liquid comprises the following steps:

[0020] (1) Weigh Phellodendron amurense, raw rhubarb, raw Platycladus orientalis leaves, turmeric, and white willow bark, and grind the Chinese medicines into coarse powder;

[0021] (2) The stock solution is obtained by water extraction and alcohol precipitation method: 2-3 times water is added to decoct the crude Chinese medicine powder, decoct 1-2 times, filter the filtrate, concentrate it according to the weight ratio of filtrate to Chinese medicine composition of 1:2-1:6, add 75%-95% ethanol, let it stand for 1-5 days, filter and remove the residue to obtain the stock solution.

[0022] (3) Distilling and diluting the stock solution: distilling the stock solution to remove alcohol, adding water to dilute it, and preparing a Chinese medicine extract with a concentration of 10%-50%;

[0023] (4) Add 1-1.8% salicylic acid, 0.05-0.2% benzoic acid, and 0.05% eucalyptol to every 100 ml of the traditional Chinese medicine extract.

[0024] The fourth aspect of the present invention provides the use of the above-mentioned Chinese medicine composition or external hair growth liquid in medicines or cosmetics for treating hair loss.

[0025] Preferably, the treatment of hair loss is the treatment of hair loss in young and middle-aged people.

[0026] The beneficial effects achieved by the present invention are as follows:

[0027] The present invention provides a Chinese medicine hair growth composition and an external hair growth liquid, which have the effect of hair growth and development, and have a good therapeutic effect on hair loss in young and middle-aged people. White willow bark can be used as a natural exfoliating ingredient, and has anti-inflammatory and analgesic effects. For young and middle-aged people with scalp problems caused by inflammation, white willow bark extract can also play an improvement role and help reduce inflammatory reactions. Turmeric contains ingredients such as curcumin, which have a good vasodilatory effect. Turmeric also has a certain improvement effect on androgenic alopecia, and can inhibit the adverse effects of androgens on hair follicles. The present invention selects white willow bark and turmeric on the basis of Phellodendron chinense, raw rhubarb and raw Platycladus orientalis leaves, which can produce unexpected effects on hair growth and development.

[0028] Meanwhile, the external hair growth liquid of the present invention can be made into an external product, has the effects of removing oil and stopping dandruff, and is green, mild, safe and reliable for long-term use.

[0029] The raw materials used in the present invention are commonly used drugs, economical and affordable, can be mass-produced, and have no toxic side effects. The present invention optimizes the prescription through experimental research to prepare the most suitable external liquid, which is easy to use, easy to apply, has no greasy feeling, and is highly safe. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 :Comparison of hair before and after treatment in case 1

[0031] Figure 2 :Comparison of hair before and after treatment in case 2

[0032] Figure 3 :Comparison of hair before and after treatment in case 3

[0033] Figure 4 :Case 4 hair comparison before and after treatment

[0034] Figure 5 :Case 5 hair comparison before and after treatment

[0035] Figure 6 :Comparison of hair before and after treatment of case 6

[0036] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0037] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0038] The experimental methods in the following examples are conventional methods unless otherwise specified; the experimental materials used in the following examples are purchased from commercial channels unless otherwise specified.

[0039] Example 1

[0040] Prepare the external hair growth solution 1 as follows:

[0041] 1. Composition

[0042] (1) Ingredient 1: Phellodendron amurense 100g, raw rhubarb 50g, raw Platycladus orientalis leaves 300g, turmeric 100g, white willow bark 250g.

[0043] (2) Ingredient 2: salicylic acid, benzoic acid, eucalyptol.

[0044] 2. Preparation

[0045] (1) Crush the Chinese medicine in ingredient 1 into coarse powder.

[0046] (2) Water extraction and alcohol precipitation method: add 2 times water to decoct the crude Chinese medicine powder, decoct twice, filter the filtrate, concentrate it according to the weight ratio of filtrate to Chinese medicine composition 1:4, add 75% ethanol, let it stand for 3 days, filter and remove the residue to obtain the original solution.

[0047] (3) distilling and diluting the stock solution: distilling the stock solution to remove alcohol, adding water to dilute it, and preparing a Chinese medicine extract with a concentration of 30%;

[0048] (4) Add ingredient 2 until every 100 ml of the Chinese herbal extract contains 1-1.8% salicylic acid, 0.05-0.2% benzoic acid, and 0.05% eucalyptol; thus, the external hair growth solution 1 is obtained.

[0049] Example 2

[0050] Prepare external hair growth solution 2 as follows:

[0051] 1. Composition

[0052] (1) Ingredient 1: 150g Phellodendron amurense, 50g raw rhubarb, 350g raw Platycladus orientalis leaves, 50g turmeric, 200g white willow bark.

[0053] (2) Ingredient 2: salicylic acid, benzoic acid, eucalyptol.

[0054] According to the method of Example 1, prepare external hair growth liquid 2.

[0055] Example 3

[0056] Prepare external hair growth solution 3 as follows:

[0057] 1. Composition

[0058] (1) Ingredient 1: Phellodendron amurense 100g, raw rhubarb 50g, raw Platycladus orientalis leaves 300g, Isatis indigotica leaves 200g, Portulaca oleracea 200g.

[0059] (2) Ingredient 2: salicylic acid, benzoic acid, eucalyptol.

[0060] According to the method of Example 1, prepare external hair growth liquid 3.

[0061] Example 4

[0062] Prepare external hair growth solution 4 as follows:

[0063] 1. Composition

[0064] (1) Ingredient 1: 250g Phellodendron amurense, 150g raw rhubarb, 400g raw Platycladus orientalis leaves.

[0065] (2) Ingredient 2: salicylic acid, benzoic acid, eucalyptol.

[0066] According to the method of Example 1, prepare external hair growth liquid 4.

[0067] Experimental Example 1 Clinical Trial

[0068] The external hair growth liquid of Examples 1-4 was used to conduct corresponding clinical trials, and the specific tests are as follows:

[0069] Clinical observation and efficacy: 100 patients with hair loss were selected, all of whom met the clinical diagnostic criteria. Among them, there were 54 males and 46 females, aged 18-45 years, with a course of disease of 1 month-3 years, and chemotherapy-induced hair loss was excluded. There were no patients with hypertension, diabetic aldosteronism, hypokalemia, liver and kidney dysfunction, pregnant women, or lactating women. Among them, 29 patients had androgenic alopecia, 35 patients had female pattern alopecia, 18 patients had alopecia areata, and the rest had other types of hair loss.

[0070] Treatment method: Apply the hair growth liquid to the hair loss area and massage gently with your fingertips for 2 to 3 minutes, twice a day. A course of treatment is 3 months, and the effect will be evaluated after 2 courses of treatment.

[0071] Treatment criteria and treatment effects: refer to Weiss criteria, cured: all new hair grows and is the same as normal hair; markedly effective: more than 50% of new hair grows, and more vellus hair becomes terminal hair; effective: more than 10% of new hair grows but grows slowly; ineffective: no new hair regeneration or less than 10% of new hair grows, or hair grows and falls off at the same time;

[0072] Total effective rate: (number of cured cases + number of markedly effective cases + number of effective cases) / total number of cases * 100%

[0073] The test results are shown in Table 1:

[0074] Table 1 Effects of each group on the treatment of hair loss

[0075]

[0076]

[0077] It can be seen from the results in Table 1 that the total effective rate of the external hair growth liquid of the present invention on young and middle-aged hair loss patients is more than 80%, and the hair loss problem can be effectively alleviated.

[0078] Experimental Example 2 Clinical Case

[0079] Some of the patients treated in Example 1 exhibited:

[0080] Case 1: Wang, female, 18 years old, diagnosed with female pattern hair loss, used the external hair growth solution 1 of the present invention for 2 courses of treatment. After treatment, more than 10% of new hair grew, and new vellus hair was visible. Efficacy evaluation: effective. Comparison of hair before and after treatment is shown in Figure 1 .

[0081] Case 2: Zhang, male, 25 years old, diagnosed with seborrheic dermatitis combined with early androgenic alopecia, after two courses of treatment with the topical hair growth solution 1 of the present invention, more than 50% of new hair grew after treatment, more vellus hair became terminal hair, and more vellus hair was visible. Efficacy evaluation: markedly effective. Comparison of hair before and after treatment: Figure 2 .

[0082] Case 3: Li, female, 31 years old, diagnosed with female pattern hair loss, used the external hair growth solution 1 of the present invention for 2 courses of treatment. After treatment, more than 50% of new hair grew, more vellus hair became terminal hair, and more vellus hair was visible. Efficacy evaluation: markedly effective. Comparison of hair before and after treatment: Figure 3 .

[0083] Case 4: Zhou, female, 31 years old, diagnosed with female pattern hair loss, used the external hair growth solution 1 of the present invention for 2 courses of treatment, and all new hair grew after treatment and was the same as normal hair. Efficacy evaluation: cured. Comparison of hair before and after treatment is shown in Figure 4 .

[0084] Case 5: Yang, male, 38 years old, diagnosed with androgenic alopecia, used the topical hair growth solution 1 of the present invention for 2 courses of treatment. After treatment, more than 50% of new hair grew, more vellus hair became terminal hair, and more vellus hair was visible. Efficacy evaluation: markedly effective. Comparison of hair before and after treatment: Figure 5 .

[0085] Case 6: Tang, female, 27 years old, diagnosed with alopecia areata, used the external hair growth solution 1 of the present invention for 2 courses of treatment. After treatment, more than 50% of new hair grew, more vellus hair became terminal hair, and more vellus hair was visible. Efficacy evaluation: markedly effective. Comparison of hair before and after treatment: Figure 6 .

[0086] It can be seen that the external hair growth liquid of the present invention has a good effect on female pattern hair loss, androgenic alopecia and alopecia areata, can grow hair and solve the problem of hair loss in young and middle-aged people.

[0087] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

Claims

1. A Chinese medicine hair growth composition, characterized in that: The traditional Chinese medicine hair growth composition consists of 50-150 parts of phellodendron, 30-60 parts of raw rhubarb, 250-350 parts of raw arborvitae leaves, 50-150 parts of turmeric and 150-300 parts of white willow bark.

2. The Chinese medicine hair growth composition according to claim 1, characterized in that: The traditional Chinese medicine hair growth composition is composed of 100 parts of phellodendron, 50 parts of raw rhubarb, 300 parts of raw arborvitae leaves, 100 parts of turmeric and 250 parts of willow bark.

3. The Chinese medicine hair growth composition according to claim 2, characterized in that: The traditional Chinese medicine hair growth composition is composed of 50-150g of Phellodendron chinense, 30-60g of raw rhubarb, 250-350g of raw Platycladus orientalis leaves, 50-150g of turmeric, and 150-300g of white willow bark; Preferably, 100g of Phellodendron chinense, 50g of raw rhubarb, 300g of raw Platycladus orientalis leaves, 100g of turmeric, and 250g of white willow bark.

4. A hair growth liquid for external use, characterized in that: The external hair growth liquid is prepared from the traditional Chinese medicine hair growth composition according to any one of claims 1 to 3 and salicylic acid, benzoic acid and eucalyptol.

5. The external hair growth liquid according to claim 4, characterized in that: The external hair growth liquid is prepared by preparing the Chinese medicine hair growth composition into a Chinese medicine extract through a water extraction and alcohol precipitation method, and then adding salicylic acid, benzoic acid and eucalyptol.

6. The external hair growth liquid according to claim 4, characterized in that: 1-1.8% salicylic acid, 0.05-0.2% benzoic acid and 0.05% eucalyptol are added to every 100ml of the traditional Chinese medicine extract.

7. The method for preparing the external hair growth liquid according to any one of claims 4 to 6, characterized in that: The steps include: (1) Weigh each component of the Chinese medicine composition and crush the Chinese medicine into coarse powder; (2) Using water extraction and alcohol precipitation method to obtain the stock solution; (3) distilling and diluting the stock solution to obtain a Chinese medicine extract; (4) Add salicylic acid, benzoic acid and eucalyptol.

8. The preparation method according to claim 7, characterized in that: The steps include: (1) Weigh 50-150 g of Phellodendron chinense, 30-60 g of raw rhubarb, 250-350 g of raw Platycladus orientalis leaves, 50-150 g of turmeric, and 150-300 g of white willow bark, and crush the Chinese medicines into coarse powder; (2) The stock solution is obtained by water extraction and alcohol precipitation method: 2-3 times water is added to decoct the crude Chinese medicine powder, decoct 1-2 times, filter the filtrate, concentrate it according to the weight ratio of filtrate to Chinese medicine composition of 1:2-1:6, add 75%-95% ethanol, let it stand for 1-5 days, filter and remove the residue to obtain the stock solution. (3) Distilling and diluting the stock solution: distilling the stock solution to remove alcohol, adding water to dilute it, and preparing a Chinese medicine extract with a concentration of 10%-50%; (4) Add 1-1.8% salicylic acid and 0.05-0.2% benzoic acid to every 100 ml of the Chinese herbal extract. 0.05% eucalyptol.

9. Use of the Chinese medicine composition according to any one of claims 1 to 3 or the external hair growth liquid according to any one of claims 4 to 6 in the preparation of a medicine or cosmetic for treating hair loss.

10. The use according to claim 9, wherein the treatment of hair loss is the treatment of hair loss in young and middle-aged people.

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