Absorption column exhaust device and method

Abstract

The invention provides an adsorption column exhaust device and method, and relates to the technical field of blood purification. The adsorption column exhaust device comprises a flushing device, a vacuumizing device and a waste liquid tank, the flushing device is connected to one end of the adsorption column, the vacuumizing device is connected to the other end of the adsorption column, and the vacuumizing device is connected to the waste liquid tank; wherein the vacuumizing device can vacuumize the adsorption column, so that negative pressure is generated in the adsorption column, and bubbles in the adsorption column are expanded under the negative pressure; in the process of vacuumizing the adsorption column, when the pressure in the adsorption column meets the preset pressure condition, the flushing device can convey flushing fluid into the adsorption column, and conveying of the flushing fluid into the adsorption column is stopped after a preset duration; the vacuumizing device can also extract the flushing fluid in the adsorption column and convey the flushing fluid to the waste liquid tank, and meanwhile, the bubbles in the adsorption column are taken away. On the basis, the gas in the adsorption column can be effectively discharged, the adsorption efficiency of the adsorption column on pathogenic substances is improved, and the safety of immunoadsorption is ensured.

Description

Technical Field

[0001] The present application relates to the technical field of blood purification, and in particular to an adsorption column exhaust device and method. Background Art

[0002] Blood purification is a technology that uses extracorporeal circulation to remove certain pathogenic substances from the patient's blood. Specifically, the patient's blood is drawn out of the body, purified through a purification device (i.e., certain pathogenic substances are removed from the blood), and the purified blood is returned to the patient's body, ultimately achieving the purpose of treating diseases, such as kidney disease, poisoning, autoimmune diseases, and liver diseases. There are many ways to purify blood, such as hemodialysis, hemofiltration, hemoperfusion, plasma exchange, and immunoadsorption, but in recent years, immunoadsorption has been used more and more widely.

[0003] Immunoadsorption refers to combining highly specific antigens, antibodies or substances with specific physical and chemical affinity (called ligands) with adsorption materials (called carriers) to form adsorbents, and then loading the adsorbents into columns to form adsorption columns, and selectively or specifically removing pathogenic substances in the blood through the adsorption columns, thereby achieving the purpose of purifying blood and treating diseases. In related technologies, adsorption columns are usually prepared using fine granular adsorbents, which makes it difficult to discharge air once it is mixed into the adsorption column, and the air remaining in the adsorption column will seriously affect the flushing of the adsorption column. The residual air will block the liquid flushing flow path, resulting in insufficient flushing of the adsorption column. The residual harmful substances may cause coagulation, allergies, stress reactions, etc., causing serious damage. When the adsorption column is used, bubbles enter the blood, exceeding the carrying and dissolving capacity of the blood, which may cause coagulation and symptoms of air embolism. The patient will experience discomfort such as dyspnea and headache, and severe cases may be life-threatening. This not only reduces the adsorption efficiency of the adsorption column for pathogenic substances, but also cannot guarantee the safety of immunoadsorption. Summary of the invention

[0004] The present application provides an adsorption column exhaust device and method, aiming to solve the problems in the related art that the adsorption column has low adsorption efficiency for pathogenic substances and insufficient safety of immunoadsorption.

[0005] In order to solve the above-mentioned drawbacks existing in the related art, the first aspect of the present application provides an adsorption column exhaust device, including a flushing device, a vacuum device and a waste liquid tank, wherein the flushing device is used to connect one end of the adsorption column, the vacuum device is used to connect the other end of the adsorption column, and the vacuum device is connected to the waste liquid tank. Among them, the vacuum device is used to vacuum the adsorption column, so that a negative pressure is generated in the adsorption column, and the bubbles in the adsorption column expand under the negative pressure; the flushing device is used to transport flushing liquid into the adsorption column when the pressure in the adsorption column meets the preset pressure condition during the process of vacuuming the adsorption column, and stop transporting flushing liquid into the adsorption column after a preset time; the vacuum device is also used to extract the flushing liquid in the adsorption column and transport it to the waste liquid tank, while taking away the bubbles in the adsorption column.

[0006] In some implementation schemes, the adsorption column exhaust device also includes a central controller that is communicatively connected to the flushing device and the vacuuming device, and the central controller is used to control the operation of the flushing device and the vacuuming device.

[0007] In some implementation schemes, the vacuum pump includes a first connector, a vacuum pump, a liquid extraction tube and a liquid delivery tube. The vacuum pump is communicatively connected to the central controller. One end of the liquid delivery tube is connected to the waste liquid tank and the other end is connected to the vacuum pump. One end of the liquid extraction tube is connected to the first connector and the other end is connected to the vacuum pump. The first connector is used to connect one end of the adsorption column.

[0008] In some implementations, the vacuum pumping device further includes a balance chamber and a pressure detector, wherein the balance chamber is connected between the first connector and the vacuum pump via a liquid extraction tube, the pressure detector is connected to the balance chamber, and the pressure detector is communicatively connected to the central controller. The balance chamber is used to balance the pressure fluctuations in the adsorption column by accommodating and releasing its own gas during the process of vacuuming the adsorption column; the pressure detector is used to detect the pressure data in the balance chamber in real time; the central controller is used to determine whether the pressure data meets the preset pressure conditions, and control the flushing device to deliver flushing liquid to the adsorption column when the preset pressure conditions are met.

[0009] In some implementations, the vacuum device further includes a timing module, which is communicatively connected to the central controller. On this basis, the central controller is further configured to control the timing module to start timing after the flushing liquid is delivered to the adsorption column, and to control the flushing device to stop delivering the flushing liquid to the adsorption column after the time counted by the timing module reaches a preset time.

[0010] In some implementations, the vacuum device further includes a sterilizing filter, and the sterilizing filter is connected between the first connector and the vacuum pump via a liquid extraction tube.

[0011] In some implementations, the vacuum pumping device further includes a first solenoid valve, which is communicatively connected to the central controller, and the first solenoid valve is connected between the first connector and the vacuum pump via a liquid extraction pipe. The first solenoid valve is used to connect the liquid extraction pipe when it is opened, or to disconnect the liquid extraction pipe when it is closed; the central controller is used to control the first solenoid valve to open to connect the liquid extraction pipe before vacuuming the adsorption column.

[0012] In some implementations, the vacuum pumping device further includes a liquid extraction one-way valve, which is connected between the first connector and the vacuum pump via a liquid extraction tube.

[0013] In some implementation schemes, the vacuum pumping device further includes a liquid delivery one-way valve, which is connected between the vacuum pump and the waste liquid tank through a liquid delivery pipe.

[0014] In some implementation schemes, the vacuum pump includes a first vacuum pump and a second vacuum pump, the liquid delivery pipe includes a first liquid delivery pipe, a second liquid delivery pipe and a third liquid delivery pipe, the liquid delivery one-way valve includes a first liquid delivery one-way valve and a second liquid delivery one-way valve, the first vacuum pump is connected to the liquid extraction pipe, one end of the first liquid delivery pipe is connected to the first vacuum pump, and the other end is connected to the second vacuum pump, one end of the second liquid delivery pipe is connected to the second vacuum pump, and the other end is connected to the waste liquid tank, one end of the third liquid delivery pipe is connected to the first liquid delivery pipe, and the other end is connected to the waste liquid tank, the first liquid delivery one-way valve is connected between the second vacuum pump and the waste liquid tank through the second liquid delivery pipe, and the second liquid delivery one-way valve is connected between the first liquid delivery pipe and the waste liquid tank through the third liquid delivery pipe.

[0015] In some implementation schemes, the flushing device includes a second connector, an infusion tube, an infusion pump and a liquid storage tank for storing flushing liquid. The second connector is used to connect to one end of the adsorption column. The liquid storage tank, the infusion pump and the second connector are connected in sequence through the infusion tube. The infusion pump is communicatively connected to the central controller.

[0016] In some implementations, the flushing device further includes a second solenoid valve, which is connected between the second connector and the infusion pump through an infusion tube and is communicatively connected to the central controller. The second solenoid valve is used to connect the infusion tube when it is opened, or to disconnect the infusion tube when it is closed; the central controller is used to control the second solenoid valve to open to connect the infusion tube before delivering the flushing liquid into the adsorption column.

[0017] The second aspect of the present application provides an adsorption column exhaust method, which is applied to the adsorption column exhaust device mentioned in the first aspect of the present application, including: a vacuum device vacuums the adsorption column, so that a negative pressure is generated in the adsorption column, and the bubbles in the adsorption column expand under the negative pressure; in the process of vacuuming the adsorption column, when the pressure in the adsorption column meets the preset pressure condition, the flushing device transports flushing liquid into the adsorption column, and stops transporting flushing liquid into the adsorption column after a preset period of time; the vacuum device extracts the flushing liquid in the adsorption column and transports it to a waste liquid tank, while taking away the bubbles in the adsorption column.

[0018] The adsorption column exhaust device provided in the first aspect of the present application includes a flushing device, a vacuum device and a waste liquid tank. The flushing device is used to connect one end of the adsorption column, the vacuum device is used to connect the other end of the adsorption column, and the vacuum device is connected to the waste liquid tank. During the actual exhaust process of the adsorption column, the vacuum pumping device can vacuum the adsorption column to exhaust the air in the adsorption column. At the same time, negative pressure will be generated in the adsorption column, and the bubbles in the adsorption column will expand under the negative pressure. As the volume of the bubbles increases, the bubbles will migrate from the inside of the adsorption column to the outer surface of the adsorption column, and finally be discharged from the adsorption column. However, since there are a large number of fine granular adsorbents in the adsorption column, some bubbles will still be trapped between these granular adsorbents and thus remain in the adsorption column; thereafter, as the vacuum pumping device continues to vacuum the adsorption column, when the pressure in the adsorption column meets the preset pressure conditions, the flushing device can transport flushing liquid to the adsorption column within a preset time period, and the flushing liquid entering the adsorption column will occupy the space in the adsorption column and have an exclusion effect on the bubbles remaining in the adsorption column. As the vacuum pumping device extracts the flushing liquid in the adsorption column, the bubbles remaining in the adsorption column will be pushed toward the vacuum pumping device by the flushing liquid, and will eventually be transported to the waste liquid tank together with the flushing liquid by the vacuum pumping device. It can be seen that when venting the adsorption column, the present application first performs preliminary venting of the adsorption column through a vacuum device to expel the air and most of the bubbles in the adsorption column, and then performs secondary venting of the adsorption column through a flushing device combined with a vacuum device to expel the bubbles remaining in the adsorption column. The venting of the adsorption column is more thorough and can avoid coagulation. It not only improves the adsorption efficiency of the adsorption column for pathogenic substances, but also ensures the safety of immunoadsorption.

[0019] Regarding the adsorption column exhaust method provided in the second aspect of the present application, since the exhaust method is implemented based on the adsorption column exhaust device provided in the first aspect of the present application, the exhaust method has all the advantages of the adsorption column exhaust device provided in the first aspect of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the related technologies or the embodiments of the present application, the drawings required for use in the description of the related technologies or the embodiments of the present application will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present application, not all embodiments. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0021] Figure 1 A module block diagram of an adsorption column exhaust device provided in an embodiment of the present application;

[0022] Figure 2 A schematic diagram of the structure of the adsorption column exhaust device provided in an embodiment of the present application;

[0023] Figure 3 A schematic diagram of the process of the adsorption column exhaust method provided in an embodiment of the present application.

[0024] The symbols in the above drawings represent:

[0025] 100-flushing device, 200-vacuuming device, 300-waste liquid tank, 400-central controller, 101-second connector, 102-infusion tube, 103-infusion pump, 104-liquid storage tank, 105-second solenoid valve, 201-first connector, 202-liquid extraction tube, 203-liquid delivery tube, 204-vacuum pump, 205-balance chamber, 206-pressure detector, 207-sterilizing filter, 208-first solenoid valve, 209-liquid extraction check valve, 210-liquid delivery check valve, 2031-first liquid delivery tube, 2032-second liquid delivery tube, 2033-third liquid delivery tube, 2041-first vacuum pump, 2042-second vacuum pump, 2101-first liquid delivery check valve, 2102-second liquid delivery check valve. DETAILED DESCRIPTION

[0026] In the related art, fine granular adsorbents are usually used to prepare adsorption columns, which makes it difficult to discharge air once it is mixed into the adsorption column, and the air remaining in the adsorption column will seriously affect the flushing of the adsorption column and even cause blood coagulation, which not only reduces the adsorption efficiency of the adsorption column for pathogenic substances, but also cannot ensure the safety of immunoadsorption. In view of this, the present application proposes an adsorption column exhaust device in the following embodiments to solve the above-mentioned drawbacks in the related art.

[0027] In order to make the purpose, technical solutions and advantages of the present application more obvious and easy to understand, the present application will be clearly and completely described below in conjunction with the embodiments of the present application and the corresponding drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions. It should be understood that the embodiments of the present application described below are only used to explain the present application and are not used to limit the present application, that is, based on the embodiments of the present application, all other embodiments obtained by ordinary technicians in this field without making creative work belong to the scope of protection of the present application. In addition, the technical features involved in the various embodiments of the present application described below can be combined with each other as long as they do not conflict with each other.

[0028] See also Figure 1 , Figure 1 It is a module block diagram of an adsorption column exhaust device. The present embodiment provides an adsorption column exhaust device, which includes a flushing device 100, a vacuum device 200 and a waste liquid tank 300. The flushing device 100 is used to connect one end of the adsorption column, the vacuum device 200 is used to connect the other end of the adsorption column, and the vacuum device 200 is also connected to the waste liquid tank 300. Specifically, the vacuum device 200 is used to vacuum the adsorption column so that a negative pressure is generated in the adsorption column, and the bubbles in the adsorption column expand under the negative pressure; the flushing device 100 is used to transport flushing liquid into the adsorption column when the pressure in the adsorption column meets the preset pressure condition during the process of vacuuming the adsorption column, and stop transporting flushing liquid into the adsorption column after a preset time; the vacuum device 200 is also used to extract the flushing liquid in the adsorption column and transport it to the waste liquid tank 300, while taking away the bubbles in the adsorption column.

[0029] That is to say, in the actual exhaust process of the adsorption column, the vacuum device 200 can vacuum the adsorption column to exhaust the air in the adsorption column. At the same time, negative pressure will be generated in the adsorption column, and the bubbles in the adsorption column will expand under the negative pressure. As the volume of the bubbles increases, the bubbles will migrate from the inside of the adsorption column to the outer surface of the adsorption column and eventually be discharged from the adsorption column. However, since there are a large number of fine granular adsorbents in the adsorption column, some bubbles will still be trapped between these granular adsorbents and remain in the adsorption column. Afterwards, as the vacuum device 200 continues to vacuum the adsorption column, when the pressure in the adsorption column meets the preset pressure condition, the flushing device 100 can transport flushing liquid to the adsorption column within a preset time period, and the flushing liquid entering the adsorption column will occupy the space in the adsorption column and have an expelling effect on the bubbles remaining in the adsorption column. As the vacuum device 200 extracts the flushing liquid in the adsorption column, the bubbles remaining in the adsorption column will be pushed toward the vacuum device 200 by the flushing liquid, and will eventually be transported to the waste liquid tank 300 by the vacuum device 200 together with the flushing liquid.

[0030] In this embodiment, during the process of evacuating the adsorption column, the "flushing device 100 delivers flushing liquid into the adsorption column within a preset time period" can be repeated multiple times, such as 2 times, 3 times, etc., so that the exhaust effect of the adsorption column can be optimized and the air and bubbles in the adsorption column can be discharged more thoroughly. Specifically, during the process of evacuating the adsorption column, when the pressure in the adsorption column meets the preset pressure condition, the flushing device 100 can deliver flushing liquid into the adsorption column for the first time and stop delivering flushing liquid into the adsorption column after the preset time period; thereafter, as the vacuuming device 200 continues to evacuate the adsorption column, when the pressure in the adsorption column meets the preset pressure condition again, the flushing device 100 can deliver flushing liquid into the adsorption column for the second time and stop delivering flushing liquid into the adsorption column after the preset time period; and so on, until the number of "flushing device 100 delivers flushing liquid into the adsorption column within the preset time period" reaches the preset number, and the exhaust of the adsorption column is completed.

[0031] In the present embodiment, the adsorption column is located in the blood purification extracorporeal circulation system for the patient. For the adsorption column arranged in the blood purification extracorporeal circulation system, one end thereof is connected to the patient's arterial measurement (i.e., connected to the patient's artery through an arterial valve), and the other end is connected to the patient's venous measurement (i.e., connected to the patient's vein through a venous valve). At this time, the adsorption column exhaust device can exhaust the adsorption column online; however, it should be noted that when the adsorption column is exhausted online using the adsorption column exhaust device, the arterial valve on the arterial side and the venous valve on the venous side need to be closed. Of course, in other embodiments, the adsorption column can also be taken out of the blood purification extracorporeal circulation system, and then the taken out adsorption column is exhausted separately. Those skilled in the art should understand that when exhausting the adsorption column, whether to set the adsorption column in the blood purification extracorporeal circulation system or to take the adsorption column out of the blood purification extracorporeal circulation system can be selected according to actual needs, and this application does not make a sole limitation on this.

[0032] In this embodiment, when controlling the operation of the flushing device 100 and the vacuum device 200, manual control or automatic control, or even a combination of manual and automatic control, can be used. The specific selection can be based on actual needs, and this application does not make a unique limitation on this. Preferably, in order to improve the intelligence and automation of the adsorption column exhaust device, the flushing device 100 and the vacuum device 200 are controlled in an automatic manner. Based on this, the adsorption column exhaust device includes, in addition to the structure given above, a central controller 400, and the flushing device 100 and the vacuum device 200 are respectively connected to the central controller 400 for communication, and the central controller 400 is used to control the operation of the flushing device 100 and the vacuum device 200. In addition, it should be noted that the central controller 400 can use any controller commonly used in the art, such as a small computer, a microcontroller such as a single-chip microcomputer, an industrial control computer (IPC), a programmable logic controller (PLC), a distributed control system (DCS), etc., which can be selected according to actual needs, and this application does not make a unique limitation on this.

[0033] As can be seen from the above, when exhausting the adsorption column, the present embodiment first performs preliminary exhaust of the adsorption column through the vacuum device 200 to exhaust the air and most of the bubbles in the adsorption column, and then performs secondary exhaust of the adsorption column through the flushing device 100 combined with the vacuum device 200 to exhaust the bubbles remaining in the adsorption column. The exhaust of the adsorption column is more thorough, which can avoid causing blood coagulation, not only improving the adsorption efficiency of the adsorption column for pathogenic substances, but also ensuring the safety of immunoadsorption. Moreover, in the present embodiment, the preliminary exhaust of the adsorption column by the vacuum device 200 is carried out continuously. During this process, the adsorption column can be subjected to multiple rounds of secondary exhaust to optimize the exhaust effect of the adsorption column.

[0034] In some embodiments, see Figure 2 , Figure 2The structure diagram of the adsorption column exhaust device is shown. The vacuum device 200 includes a first connector 201, a vacuum pump 204, a liquid extraction pipe 202 and a liquid delivery pipe 203. One end of the liquid delivery pipe 203 is connected to the waste liquid tank 300 and the other end is connected to the vacuum pump 204. One end of the liquid extraction pipe 202 is connected to the first connector 201 and the other end is connected to the vacuum pump 204. The first connector 201 is used to connect one end of the adsorption column. The vacuum pump 204 is communicatively connected to the central controller 400. In the actual exhaust process of the adsorption column, when the vacuum device 200 is required to vacuum the adsorption column, the central controller 400 can control the vacuum pump 204 to start. After starting, the vacuum pump 204 can vacuum the adsorption column through the liquid extraction pipe 202, thereby extracting the air in the adsorption column. It should be noted that the first connector 201 can adopt any pipe connector commonly used in the art, such as a Luer connector, a compression connector, and a flange connector, etc. The specific selection can be based on actual needs, and this application does not make a sole limitation on this.

[0035] In some embodiments, see Figure 2 In addition to the structure given above, the vacuum pumping device 200 also includes a balance chamber 205 and a pressure detector 206. The balance chamber 205 is connected between the first connector 201 and the vacuum pump 204 through the liquid extraction tube 202. The pressure detector 206 is connected to the balance chamber 205, and the pressure detector 206 is communicatively connected to the central controller 400. Specifically, the balance chamber 205 is used to balance the pressure fluctuation in the adsorption column by accommodating and releasing its own gas during the process of vacuuming the adsorption column; the pressure detector 206 is used to detect the pressure data in the balance chamber 205 in real time; the central controller 400 is used to determine whether the pressure data meets the preset pressure conditions, and control the flushing device 100 to deliver flushing liquid to the adsorption column when the preset pressure conditions are met. It should be noted that the pressure detector 206 can adopt devices with pressure detection function commonly used in this field, such as U-tube pressure gauge, inclined micromanometer, spring tube pressure gauge, diaphragm pressure gauge, bellows pressure gauge, strain gauge pressure sensor, piezoresistive pressure sensor, capacitive pressure sensor and piston pressure gauge, etc. The specific selection can be made according to actual needs, and this application does not make the sole limitation on this.

[0036] That is to say, during the process of the vacuum device 200 vacuuming the adsorption column, the pressure detector 206 can detect the pressure data in the balance chamber 205 in real time, and transmit the detected pressure data to the central controller 400, and the central controller 400 can determine whether the pressure data in the balance chamber 205 meets the preset pressure condition. When the central controller 400 determines that the pressure data in the balance chamber 205 meets the preset pressure condition, the central controller 400 can control the flushing device 100 to transport the flushing liquid into the adsorption column. In addition, it should be noted that although the pressure detector 206 detects the pressure data in the balance chamber 205, the pressure data in the balance chamber 205 can be used to indicate the pressure in the adsorption column, and can also be used to indicate the pressure in the liquid extraction pipe 202 between the adsorption column and the vacuum pump 204.

[0037] As one or more embodiments, the preset pressure condition is to reach the preset pressure threshold, that is, when the central controller 400 determines that the pressure data in the balance chamber 205 reaches the preset pressure threshold, the central controller 400 will control the flushing device 100 to deliver flushing liquid to the adsorption column; preferably, the preset pressure threshold is -0.09MPa. Of course, in other embodiments, other preset pressure conditions may also be used, such as the preset pressure condition is to reach the preset pressure threshold, and after a certain time (such as 10s) after reaching the preset pressure threshold, that is, the pressure data in the balance chamber 205 reaches the preset pressure threshold. In the 10th second, the central controller 400 will control the flushing device 100 to deliver flushing liquid to the adsorption column. Those skilled in the art should understand that the preset pressure condition can be set according to actual needs, and this application does not make a sole limitation on this.

[0038] It is understandable that the pumping rate of the vacuum pump 204 when it is working may not be absolutely stable, which will cause the pressure in the adsorption column to fluctuate. The balance chamber 205 is actually a pressure buffer. When the pumping rate of the vacuum pump 204 changes and causes the pressure in the adsorption column to fluctuate, the balance chamber 205 can smooth out such pressure fluctuations by accommodating and releasing its own gas, so that the pressure in the adsorption column is relatively stable; for example, when the vacuum pump 204 suddenly accelerates to pump air, the balance chamber 205 can temporarily store a part of the gas extracted from the adsorption column to prevent the pressure in the adsorption column from dropping suddenly, and when the pumping rate of the vacuum pump 204 decreases, the gas in the balance chamber 205 can be replenished in the liquid extraction pipe 202 between the adsorption column and the vacuum pump 204 to prevent the pressure in the adsorption column from rising rapidly. In addition, connecting the pressure detector 206 to the balance chamber 205 can more accurately measure the pressure of the adsorption column during the vacuuming process. Compared with the pressure detector 206 directly connected to the adsorption column or the vacuum pump 204, the balance chamber 205 provides a relatively stable measurement environment, which reduces the airflow interference during the vacuum pump 204's vacuuming and the influence of the complex environment inside the adsorption column on the pressure measurement, thereby enabling the pressure detector 206 to obtain pressure data more accurately.

[0039] Furthermore, the vacuum device 200 also includes a timing module (not shown), which is communicatively connected to the central controller 400. On this basis, the central controller 400 is also used to control the timing module to start timing after the flushing liquid is transported into the adsorption column, and control the flushing device 100 to stop transporting the flushing liquid into the adsorption column after the time counted by the timing module reaches a preset duration. That is to say, in the process of the vacuum device 200 vacuuming the adsorption column, when the pressure in the adsorption column meets the preset pressure condition, the central controller 400 can control the flushing device 100 to transport the flushing liquid into the adsorption column, and control the timing module to start timing at the same time, and after the time counted by the timing module reaches a preset duration, the central controller 400 can control the flushing device 100 to stop transporting the flushing liquid into the adsorption column. Exemplarily, the preset duration is 10s.

[0040] In some embodiments, see Figure 2In addition to the structure given above, the vacuum device 200 also includes a sterilizing filter 207, which is connected between the first connector 201 and the vacuum pump 204 through the liquid extraction pipe 202, and can be specifically connected between the first connector 201 and the balance chamber 205. It can be understood that the sterilizing filter 207 is arranged on the liquid extraction pipe 202 between the first connector 201 and the balance chamber 205, which can effectively isolate the adsorption column from the external pipeline, prevent impurities, harmful bacteria and microorganisms in the external pipeline from entering the adsorption column, and ensure that the adsorption column will not be contaminated. It should be noted that the sterilizing filter 207 can adopt a common device with sterilization and filtering functions in the art, such as a fiber-wound sterilizing filter, a melt-blown sterilizing filter, a polyethersulfone (PES) membrane sterilizing filter, a polyvinylidene fluoride (PVDF) membrane sterilizing filter, a nylon membrane sterilizing filter and a nuclear pore membrane sterilizing filter, etc., which can be selected according to actual needs, and this application does not make a sole limitation on this.

[0041] In some embodiments, see Figure 2 In addition to the above-mentioned structures, the vacuum device 200 also includes a first solenoid valve 208 that is communicatively connected to the central controller 400. The first solenoid valve 208 is connected between the first connector 201 and the vacuum pump 204 through the liquid extraction pipe 202, and can be specifically connected between the sterilizing filter 207 and the balance chamber 205. Specifically, the first solenoid valve 208 is used to connect the liquid extraction pipe 202 when it is opened, or to block the liquid extraction pipe 202 when it is closed; the central controller 400 is used to control the first solenoid valve 208 to open to connect the liquid extraction pipe 202 before vacuuming the adsorption column. That is to say, the opening / closing of the liquid extraction pipe 202 is controlled by the opening of the first solenoid valve 208. Before the vacuum extraction device 200 evacuates the adsorption column, the central controller 400 needs to control the opening of the first solenoid valve 208 to make the liquid extraction pipe 202 conductive, and then control the vacuum pump 204 to start, so that the vacuum pump 204 can evacuate the adsorption column through the conductive liquid extraction pipe 202; of course, after the exhaust of the adsorption column is completed, the central controller 400 can control the first solenoid valve 208 to close to isolate the liquid extraction pipe 202. It should be noted that the device for controlling the conduction or isolation of the liquid extraction pipe 202 is not limited to the first solenoid valve 208. In other embodiments, the first solenoid valve 208 can be replaced by other valves commonly used in the art that can control the on-off of the pipeline, such as electric valves, etc., and the second solenoid valve 105 described below is also the same.

[0042] In some embodiments, see Figure 2In addition to the above-mentioned structure, the vacuum device 200 further includes a liquid extraction check valve 209, which is connected between the first connector 201 and the vacuum pump 204 through the liquid extraction pipe 202, and can be specifically connected between the sterilizing filter 207 and the first solenoid valve 208. It can be understood that the liquid extraction check valve 209 is arranged on the liquid extraction pipe 202 between the sterilizing filter 207 and the first solenoid valve 208, which can effectively prevent the flushing liquid and other substances in the liquid extraction pipe 202 from flowing back into the adsorption column, thereby affecting the exhaust effect of the adsorption column.

[0043] In some embodiments, see Figure 2 In addition to the structure given above, the vacuum device 200 also includes a liquid delivery check valve 210, which is connected between the vacuum pump 204 and the waste liquid tank 300 through the liquid delivery pipe 203. It can be understood that the liquid delivery check valve 210 is arranged on the liquid delivery pipe 203 between the vacuum pump 204 and the waste liquid tank 300, which can effectively prevent the backflow of the flushing liquid and other substances in the liquid delivery pipe 203, thereby affecting the exhaust effect of the adsorption column.

[0044] In some embodiments, see Figure 2 The vacuum pump 204 includes a first vacuum pump 2041 and a second vacuum pump 2042. The liquid delivery pipe 203 includes a first liquid delivery pipe 2031, a second liquid delivery pipe 2032 and a third liquid delivery pipe 2033. The liquid delivery one-way valve 210 includes a first liquid delivery one-way valve 2101 and a second liquid delivery one-way valve 2102. The first vacuum pump 2041 is connected to the liquid extraction pipe 202. One end of the first liquid delivery pipe 2031 is connected to the first vacuum pump 2041 and the other end is connected to the second vacuum pump 2042. One end of the second liquid delivery pipe 2032 is connected to the second vacuum pump 2042, and the other end is connected to the waste liquid tank 300, one end of the third liquid delivery pipe 2033 is connected to the first liquid delivery pipe 2031, and the other end is connected to the waste liquid tank 300, the first liquid delivery one-way valve 2101 is connected between the second vacuum pump 2042 and the waste liquid tank 300 through the second liquid delivery pipe 2032, and the second liquid delivery one-way valve 2102 is connected between the first liquid delivery pipe 2031 and the waste liquid tank 300 through the third liquid delivery pipe 2033. It can be understood that the provision of two vacuum pumps 204 can effectively improve the vacuuming effect of the adsorption column. However, those skilled in the art should understand that the number of vacuum pumps 204 is not limited to a single / two, but can also be three or more, and the number of liquid delivery pipes 203 and liquid delivery one-way valves 210 is determined based on the number of vacuum pumps 204, and this application does not make a sole limitation on this.

[0045] In some embodiments, see Figure 2The flushing device 100 includes a second connector 101, an infusion tube 102, an infusion pump 103 and a liquid storage tank 104 for storing flushing liquid. The liquid storage tank 104, the infusion pump 103 and the second connector 101 are connected in sequence through the infusion tube 102. The second connector 101 is used to connect one end of the adsorption column, and the infusion pump 103 is communicatively connected to the central controller 400. In the process of the vacuum device 200 vacuuming the adsorption column, when the pressure in the adsorption column meets the preset pressure condition, the central controller 400 can control the infusion pump 103 to start, and the infusion pump 103 after starting can deliver the flushing liquid in the liquid storage tank 104 to the adsorption column through the infusion tube 102. It should be noted that the second connector 101 can adopt any pipe joint commonly used in the art, such as a Luer joint, a ferrule joint and a flange joint, etc., which can be selected according to actual needs, and this application does not make a sole limitation on this. It should be noted that the flushing liquid stored in the liquid storage tank 104 can be a common liquid with flushing properties in the art, such as organic solvents such as ethanol and methanol, buffer solutions such as phosphate buffered saline (PBS) and Tris-HCl buffer, deionized water, saline, etc. The specific selection can be based on actual needs, and this application does not make a sole limitation on this.

[0046] In some embodiments, see Figure 2 In addition to the structure given above, the flushing device 100 also includes a second solenoid valve 105, which is connected between the second connector 101 and the infusion pump 103 through the infusion tube 102, and the second solenoid valve 105 is communicatively connected to the central controller 400. Specifically, the second solenoid valve 105 is used to connect the infusion tube 102 when it is opened, or to cut off the infusion tube 102 when it is closed; the central controller 400 is used to control the second solenoid valve 105 to open to connect the infusion tube 102 before delivering the flushing liquid into the adsorption column. That is to say, the conduction / isolation of the infusion tube 102 is controlled by the switch of the second solenoid valve 105. When the pressure in the adsorption column meets the preset pressure condition, the central controller 400 can control the second solenoid valve 105 to open, so that the infusion tube 102 is conducted, and then control the infusion pump 103 to start, so that the infusion pump 103 can transport flushing liquid to the adsorption column through the conducted infusion tube 102; after a preset period of time, the central controller 400 can control the infusion pump 103 to stop, so as to stop transporting flushing liquid into the adsorption column, and then control the second solenoid valve 105 to close to isolate the infusion tube 102.

[0047] See also Figure 3 , Figure 3It is a flow chart of the adsorption column exhaust method. The present embodiment provides an adsorption column exhaust method, which is applied to the adsorption column exhaust device described above, and the adsorption column exhaust method includes steps 301 to 303 (abbreviated as S301 to S303), namely: S301, the vacuum device vacuums the adsorption column, so that a negative pressure is generated in the adsorption column, and the bubbles in the adsorption column expand under the negative pressure; S302, in the process of vacuuming the adsorption column, when the pressure in the adsorption column meets the preset pressure condition, the flushing device transports the flushing liquid into the adsorption column, and stops transporting the flushing liquid into the adsorption column after a preset time; S303, the vacuum device extracts the flushing liquid in the adsorption column and transports it to the waste liquid tank, while taking away the bubbles in the adsorption column. In addition, it should be noted that for the unfinished description of the adsorption column exhaust method, please refer to the relevant description of the adsorption column exhaust device in the previous text, and the present application will not elaborate here.

[0048] The above embodiments are only preferred implementations of the present application, and they are not the only limitations on the adsorption column exhaust device and related methods; in this regard, those skilled in the art can flexibly set them according to the actual application scenarios based on the above embodiments. It can be understood that through the implementation of the above embodiments of the present application, the adsorption column exhaust device is composed of a flushing device 100, a vacuum device 200 and a waste liquid tank 300, the flushing device 100 is connected to one end of the adsorption column, the vacuum device 200 is connected to the other end of the adsorption column, and the vacuum device 200 is connected to the waste liquid tank 300. During the actual exhaust process of the adsorption column, the vacuum pumping device 200 can vacuum the adsorption column to exhaust the air in the adsorption column. At the same time, negative pressure will be generated in the adsorption column, and the bubbles in the adsorption column will expand under the negative pressure. As the volume of the bubbles increases, the bubbles will migrate from the inside of the adsorption column to the outer surface of the adsorption column and eventually be discharged from the adsorption column. However, since there are a large number of fine granular adsorbents in the adsorption column, some bubbles will still be trapped between these granular adsorbents and remain in the adsorption column. Afterwards, as the vacuum pumping device 200 continues to vacuum the adsorption column, when the pressure in the adsorption column meets the preset pressure condition, the flushing device 100 can transport flushing liquid to the adsorption column within a preset time period, and the flushing liquid entering the adsorption column will occupy the space in the adsorption column and have an expelling effect on the bubbles remaining in the adsorption column. As the vacuum pumping device 200 extracts the flushing liquid in the adsorption column, the bubbles remaining in the adsorption column will be pushed toward the vacuum pumping device 200 by the flushing liquid, and will eventually be transported to the waste liquid tank 300 together with the flushing liquid by the vacuum pumping device 200. It can be seen that when venting the adsorption column, the present application will first perform preliminary venting of the adsorption column through the vacuum device 200 to expel the air and most of the bubbles in the adsorption column, and then perform secondary venting of the adsorption column through the flushing device 100 combined with the vacuum device 200 to expel the bubbles remaining in the adsorption column, so that the exhaust of the adsorption column is more thorough, which can avoid coagulation, not only improve the adsorption efficiency of the adsorption column for pathogenic substances, but also ensure the safety of immunoadsorption.

[0049] It should be noted that the several embodiments shown in the present application are described in a progressive manner, and each embodiment focuses on the differences from other embodiments, and the same or similar parts between the various embodiments can refer to each other. It should also be noted that in the text description of the present application, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply that there is such an actual relationship or order between these entities or operations. Further, the terms "include", "comprise" or any other corresponding variants are intended to cover non-exclusive inclusion, so that the process, method, article or equipment including a series of elements includes not only these elements, but also other elements that are not explicitly listed, or may also include elements inherent to such process, method, article or equipment; and, in the absence of more restrictions, the elements defined by the sentence "including one..." do not exclude the existence of other identical elements in the process, method, article or equipment including the elements.

[0050] In addition, by implementing the several embodiments shown above in the present application, professionals and technicians in this field can implement or use the present application. For the several embodiments shown above in the present application, various modifications will be obvious to professionals and technicians in this field, and the general principles defined in the present application can be implemented in other embodiments not shown without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the several embodiments shown above, but will comply with the widest range consistent with the principles and novel features disclosed in the present application.

Claims

1. An adsorption column exhaust device, characterized in that: It includes a flushing device, a vacuum device and a waste liquid tank, wherein the flushing device is used to connect one end of the adsorption column, the vacuum device is used to connect the other end of the adsorption column, and the vacuum device is connected to the waste liquid tank, wherein: The vacuum pumping device is used to vacuum the adsorption column so that negative pressure is generated in the adsorption column, and the bubbles in the adsorption column expand under the negative pressure; The flushing device is used to deliver flushing liquid into the adsorption column when the pressure in the adsorption column meets the preset pressure condition during the process of evacuating the adsorption column, and stop delivering the flushing liquid into the adsorption column after a preset time; The vacuum pumping device is also used to extract the flushing liquid in the adsorption column and transport it to the waste liquid tank, while taking away the bubbles in the adsorption column.

2. The adsorption column exhaust device according to claim 1, characterized in that: It also includes a central controller that is communicatively connected to the flushing device and the vacuuming device, and the central controller is used to control the operation of the flushing device and the vacuuming device.

3. The adsorption column exhaust device according to claim 2, characterized in that: The vacuum extraction device includes a first connector, a vacuum pump, a liquid extraction tube and a liquid delivery tube. The vacuum pump is communicatively connected to the central controller. One end of the liquid delivery tube is connected to the waste liquid tank and the other end is connected to the vacuum pump. One end of the liquid extraction tube is connected to the first connector and the other end is connected to the vacuum pump. The first connector is used to connect one end of the adsorption column.

4. The adsorption column exhaust device according to claim 3, characterized in that: The vacuum pumping device further includes a balance chamber and a pressure detector, wherein the balance chamber is connected between the first connector and the vacuum pump through the liquid extraction pipe, the pressure detector is connected to the balance chamber, and the pressure detector is communicatively connected to the central controller, wherein: The balance chamber is used to balance the pressure fluctuation in the adsorption column by accommodating and releasing gas in the balance chamber during the process of evacuating the adsorption column; The pressure detector is used to detect the pressure data in the balancing chamber in real time; The central controller is used to determine whether the pressure data meets the preset pressure condition, and control the flushing device to deliver the flushing liquid to the adsorption column when the preset pressure condition is met.

5. The adsorption column exhaust device according to claim 4, characterized in that: The vacuum pumping device further includes a timing module, and the timing module is communicatively connected to the central controller; The central controller is also used to control the timing module to start timing after the flushing liquid is transported into the adsorption column, and to control the flushing device to stop transporting the flushing liquid into the adsorption column after the time counted by the timing module reaches the preset time length.

6. The adsorption column exhaust device according to claim 3, characterized in that: The vacuum pumping device further comprises a sterilizing filter, and the sterilizing filter is connected between the first connector and the vacuum pump through the liquid extraction tube.

7. The adsorption column exhaust device according to claim 3, characterized in that: The vacuum pumping device further includes a first solenoid valve communicatively connected to the central controller, wherein the first solenoid valve is connected between the first connector and the vacuum pump via the liquid extraction pipe, wherein: The first solenoid valve is used to connect the liquid extraction pipe when it is opened, or to cut off the liquid extraction pipe when it is closed; The central controller is used to control the first solenoid valve to open to connect the liquid extraction pipe before vacuuming the adsorption column.

8. The adsorption column exhaust device according to claim 3, characterized in that: The vacuum pumping device further comprises a liquid extraction one-way valve, and the liquid extraction one-way valve is connected between the first connector and the vacuum pump through the liquid extraction pipe.

9. The adsorption column exhaust device according to claim 3, characterized in that: The vacuum pumping device further comprises a liquid delivery one-way valve, and the liquid delivery one-way valve is connected between the vacuum pump and the waste liquid tank through the liquid delivery pipe.

10. The adsorption column exhaust device according to claim 9, characterized in that: The vacuum pump includes a first vacuum pump and a second vacuum pump, the liquid delivery pipe includes a first liquid delivery pipe, a second liquid delivery pipe and a third liquid delivery pipe, the liquid delivery one-way valve includes a first liquid delivery one-way valve and a second liquid delivery one-way valve, the first vacuum pump is connected to the liquid extraction pipe, one end of the first liquid delivery pipe is connected to the first vacuum pump, and the other end is connected to the second vacuum pump, one end of the second liquid delivery pipe is connected to the second vacuum pump, and the other end is connected to the waste liquid tank, one end of the third liquid delivery pipe is connected to the first liquid delivery pipe, and the other end is connected to the waste liquid tank, the first liquid delivery one-way valve is connected between the second vacuum pump and the waste liquid tank through the second liquid delivery pipe, and the second liquid delivery one-way valve is connected between the first liquid delivery pipe and the waste liquid tank through the third liquid delivery pipe.

11. The adsorption column exhaust device according to claim 2, characterized in that: The flushing device includes a second connector, an infusion tube, an infusion pump and a liquid storage tank for storing the flushing liquid. The liquid storage tank, the infusion pump and the second connector are connected in sequence through the infusion tube. The second connector is used to connect one end of the adsorption column. The infusion pump is communicatively connected to the central controller.

12. The adsorption column exhaust device according to claim 11, characterized in that: The flushing device further includes a second solenoid valve communicatively connected to the central controller, and the second solenoid valve is connected between the second connector and the infusion pump through the infusion tube, wherein: The second solenoid valve is used to connect the infusion tube when it is opened, or to cut off the infusion tube when it is closed; The central controller is used to control the second solenoid valve to open to conduct the infusion tube before delivering the flushing liquid into the adsorption column.

13. A method for exhausting an adsorption column, characterized in that: The adsorption column exhaust device according to any one of claims 1 to 12 comprises: The vacuuming device vacuums the adsorption column, so that negative pressure is generated in the adsorption column, and the bubbles in the adsorption column expand under the negative pressure; During the process of evacuating the adsorption column, when the pressure in the adsorption column meets the preset pressure condition, the flushing device delivers flushing liquid into the adsorption column, and stops delivering the flushing liquid into the adsorption column after a preset time; The vacuum device extracts the flushing liquid in the adsorption column and transports it to a waste liquid tank, while taking away the bubbles in the adsorption column.

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