Low-temperature freezing vacuum drying system for continuous dynamic production and production method

Abstract

The invention discloses a low-temperature freezing vacuum drying system for continuous dynamic production and a production method. Comprising a vacuum drying cabin, a discharging buffer cabin arranged at the bottom of the vacuum drying cabin, a vacuum filter communicated with the vacuum drying cabin through a first pipeline, and a vacuum pump set communicated with the vacuum filter through a second pipeline. The material collector is communicated with the bottom of the discharging buffer cabin through a third pipeline, the induced draft fan is communicated with the top of the material collector through a fourth pipeline, the bottom of the vacuum filter is communicated with the material collector through a fifth pipeline, and the air blowing side of the induced draft fan is communicated with the top of the vacuum filter through a sixth pipeline. Dynamic continuous production can be achieved, materials in the vacuum drying cavity and materials in the process can be rapidly and automatically discharged, and the production efficiency is greatly improved.

Description

Technical Field

[0001] The invention belongs to the technical field of freeze drying equipment, and in particular relates to a low-temperature freeze vacuum drying system and a production method for continuous dynamic production. Background Art

[0002] The vacuum freeze drying process is commonly used in the fields of food processing, medical powder processing, etc. Traditional freeze vacuum drying equipment adopts a tray structure, such as a vacuum freeze food dryer disclosed in patent CN118602699A, which injects the raw material drug solution with water or other solvents into the freeze drying tray. Some freeze drying trays and plate layers are integrated, and some are separated. The material collection of this dryer is a very cumbersome task. In most cases, the material to be discharged must be taken out together with the tray, and manual operation is required to complete the material discharge work; even if the freeze drying tray and plate layer are integrated, in a sense, the function of automatic material feeding and discharging is realized, reducing the pollution of personnel, but the material needs to be crushed after discharging, and the crushing work requires an equally clean environment to be carried out, so the cleanliness of the entire workshop environment is required to be high, resulting in high cost of the entire system engineering; the bigger problem is that the material collection is very time-consuming. It takes at least 3 days for each batch of materials to enter the freeze dryer and discharge.

[0003] In recent years, with the increasing production capacity of polypeptide biological drugs, traditional tray-type vacuum freeze drying equipment has been far from meeting the demand for high production capacity. There are also some closed vacuum freeze dryers in the prior art, such as the internal vacuum single cone spiral freeze dryer disclosed in patent CN118089340A, the freeze dryer disclosed in patent CN116806301A and the method for freeze drying. Although the above two freeze dryers realize sealed material inlet and outlet production, it is still very time-consuming to discharge the dried materials, and can only be produced intermittently, and the production efficiency is not ideal. In the freeze dryer and the method for freeze drying disclosed in patent CN116806301A, the process materials generated during the vacuum drying chamber will enter the material collector through the vacuum flow at the top, and fall into the cavity at the bottom of the material collector after heating and secondary drying in the material collector. For the discharge of this part of the material, it is necessary to remove the collection material receiver at the bottom after each can of material is dried, pour it out and then install it on the material collector, which is cumbersome to operate. If the material collection is not carried out until a production batch is completed or the collection material receiver at the bottom is full, for materials that are greatly affected by high temperatures (such as polypeptide biological drugs), it is easy for them to be exposed to high temperatures for a long time, which may affect the pharmacological activity of the polypeptide biological drugs.

[0004] In addition, the above two sealed drying devices only disclose that materials can be released from the bottom of the conical vacuum drying chamber, but the materials are likely to cause dust and debris in the external environment when released, and the discharge is only based on the material's own weight. The discharge speed is slow and it is easy to discharge uncleanly, resulting in a long waiting time in the middle of the conical vacuum drying chamber, reducing production efficiency.

[0005] Therefore, it is necessary to provide a new low-temperature freeze-vacuum drying system and production method for continuous dynamic production to solve the above-mentioned technical problems. Summary of the invention

[0006] The main purpose of the present invention is to provide a low-temperature freezing vacuum drying system for continuous dynamic production, which can realize dynamic continuous production and realize rapid and automatic unloading of materials in the vacuum drying chamber and process materials, thereby greatly improving production efficiency.

[0007] The present invention achieves the above-mentioned purpose through the following technical scheme: A low-temperature freezing vacuum drying system for continuous dynamic production, comprising: A vacuum freeze-drying production system, the vacuum freeze-drying production system comprising a vacuum drying chamber, a vacuum filter connected to the vacuum drying chamber through a first pipeline, and a vacuum pump group connected to the vacuum filter through a second pipeline; a second control valve is provided on the first pipeline, and a third control valve is provided on the second pipeline; A main unloading system, the main unloading system comprises a discharge buffer chamber, a material collector connected to the bottom of the discharge buffer chamber through a third pipeline, and an induced draft fan connected to the top of the material collector through a fourth pipeline; the discharge buffer chamber is docked and arranged at the bottom of the vacuum drying chamber; a fourth control valve is arranged on the third pipeline; A secondary unloading system, the secondary unloading system comprising the vacuum filter, the material collector, the induced draft fan, a fifth pipeline connecting the vacuum filter and the material collector, the fourth pipeline, and a sixth pipeline connecting the induced draft fan and the vacuum filter; a fifth control valve is provided on the fifth pipeline, and a seventh control valve is provided on the sixth pipeline; A first control valve is provided at the bottom of the vacuum drying chamber to control the conduction and blocking between the vacuum drying chamber and the discharge buffer chamber.

[0008] Furthermore, a feed port and a vacuum extraction interface are provided on the top of the vacuum drying chamber, and a discharge port is provided on the bottom; the discharge buffer chamber is provided below the discharge port and docked with the bottom of the vacuum drying chamber, and the first control valve is provided at the discharge port; one end of the first pipeline is connected to the vacuum extraction interface; the feed port is connected to the material feeding system, and a control valve for controlling the opening and closing is provided on the pipeline connected to the feed port.

[0009] Furthermore, the outer peripheral surface of the vacuum drying chamber is covered with a first temperature control jacket, and the first temperature control jacket circuit is connected to the temperature controller; and a stirring mechanism is provided in the vacuum drying chamber.

[0010] Furthermore, a vacuum gauge for monitoring the vacuum degree in the second pipeline is provided on the second pipeline.

[0011] Furthermore, the outer peripheral surface of the vacuum filter is covered with a second temperature control jacket.

[0012] Furthermore, the third pipeline is provided with a PAT online monitor for monitoring set parameters of the material in the third pipeline.

[0013] Furthermore, the sixth pipeline is provided with a first pressure gauge for monitoring the pressure in the sixth pipeline; and the fourth pipeline is provided with a second pressure gauge for monitoring the pressure in the fourth pipeline.

[0014] Furthermore, the fifth pipeline and the third pipeline merge into the seventh pipeline and then are connected to the material collector, and a sixth control valve for controlling the opening and closing of the seventh pipeline is provided on the seventh pipeline.

[0015] Furthermore, the air outlet side of the induced draft fan is connected to the discharge buffer chamber through an eighth pipeline, and an eighth control valve is provided on the eighth pipeline.

[0016] Furthermore, a return air collection filter is also provided on the fourth pipeline.

[0017] Furthermore, a main discharge control valve is provided at the bottom of the material collector; a discharge port is provided at the bottom of the discharge buffer compartment, and an opening valve is provided at the discharge port.

[0018] Another object of the present invention is to provide a production method of a low-temperature freeze-vacuum drying system based on the continuous dynamic production as described above, comprising the following steps: S1. Feeding: In the initial state, all control valves are closed, and the feed liquid enters the vacuum drying chamber to achieve automatic feeding; S2, low temperature stirring: cooling the vacuum drying chamber and stirring the material at the same time, until the material liquid is stirred and frozen into the required ice particles by low temperature; S3, vacuum sublimation drying: the second control valve and the third control valve are opened, the vacuum pump group starts to work, the vacuum drying chamber is evacuated, the stirring state is maintained, and at the same time, the vacuum drying chamber is heated until the material in the vacuum drying chamber becomes the desired powder; S4, unloading: quickly unloading the powder in the vacuum drying chamber into the discharge buffer chamber; the vacuum drying chamber is quickly unloaded by method 1 or method 2; The first method is: the vacuum drying chamber is vented, and after the chamber returns to normal pressure, the first control valve, the fourth control valve, the sixth control valve and the seventh control valve are opened, the third control valve is closed, the second control valve remains in an open state, and the induced draft fan is started. Under the action of the induced draft fan, the powder in the vacuum drying chamber is quickly brought into the discharge buffer chamber, and the first control valve is closed after completion; The second method is: the vacuum drying chamber is vented, and after the chamber returns to normal pressure, the first control valve, the fourth control valve, the sixth control valve and the eighth control valve are opened, the second control valve and the third control valve are closed, and the induced draft fan is started. Under the action of the induced draft fan, the powder in the vacuum drying chamber is quickly brought into the discharge buffer chamber, and the first control valve is closed after completion; S5, discharging: the fourth control valve, the sixth control valve and the eighth control valve are kept in an open state, the induced draft fan is kept in a working state, all the materials in the discharging buffer chamber are pumped into the material collector, and then the fourth control valve, the sixth control valve and the eighth control valve are closed, and the main discharging control valve at the bottom of the material collector is opened to discharge the materials; S6, continuous production of new materials: while step S5 is being executed, new liquid feed enters the vacuum drying chamber through the feed port to complete the feeding of new materials, and steps S2 to S4 are repeated to complete the vacuum freeze drying of the new materials, thereby achieving efficient and continuous production.

[0019] Furthermore, the step S4 also includes vacuum filter process unloading; The vacuum filter process unloading: the second control valve and the third control valve are closed, the fifth control valve, the sixth control valve and the seventh control valve are opened, the induced draft fan is started, and the powder material collected in the vacuum filter during the vacuuming process is blown back into the material collector, and the fifth control valve and the seventh control valve are closed after completion.

[0020] Compared with the prior art, the beneficial effects of the low-temperature freezing vacuum drying system and production method of the present invention for continuous dynamic production are: it can realize dynamic continuous production, realize the rapid and automatic unloading of materials in the vacuum drying chamber and process materials, and greatly improve the production efficiency. Specifically: (1) By setting up a vacuum freeze drying production system, a main unloading system and a secondary unloading system, a low-temperature cold air vacuum drying production system with continuous dynamic production is formed, which realizes continuous production and closed production and discharging, and improves production efficiency and product quality; (2) The vacuum filter in the vacuum freeze-drying production system is equipped with two sets of inlet and outlet interfaces. One set of inlet and outlet interfaces is connected to the vacuum drying chamber and the vacuum pump group, and participates in the vacuum pumping pipeline to form the vacuum freeze-drying production system. The other set of inlet and outlet interfaces is connected to the material collector and the induced draft fan, and participates in the secondary unloading system, realizing the online collection of the material carried out by the liquid along with the steam flow during the vacuum pumping process and the automatic online unloading; (3) A discharge buffer chamber is arranged at the bottom of the vacuum drying chamber, which is connected to a material collector through a pipeline, and the material collector is further connected to an induced draft fan through a pipeline. The dry powder in the vacuum drying chamber is quickly extracted into the discharge buffer chamber through the induced draft fan. After all the materials in the vacuum drying chamber are extracted, the first control valve at the bottom can be closed to input the next round of new material liquid, thereby realizing uninterrupted continuous production. At the same time, the main unloading system and the secondary unloading system can realize synchronous discharge during the next round of new material liquid feeding and low-temperature freeze-drying process. The vacuum freeze-drying production system and the unloading system do not interfere with each other, thereby greatly improving production efficiency. (4) The induced draft fan is connected to the discharge buffer chamber through the seventh pipeline, so that the entire main unloading system forms a sealed circulation system, ensuring that the powder does not need to be exposed to the air during the entire unloading process, thereby improving the powder quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the principle structure of an embodiment of the present invention; The numbers in the figure represent: 200- Low temperature freeze vacuum drying system for continuous dynamic production; 1- vacuum drying chamber; 2- material discharging buffer chamber; 3- first pipeline; 4- vacuum filter; 5- second pipeline; 6- vacuum pump group; 7- third pipeline; 8- material collector; 9- fourth pipeline; 10- induced draft fan; 11- fifth pipeline; 12- sixth pipeline; 13- material inlet; 14- first control valve; 15- second control valve; 16- third control valve; 17- vacuum gauge; 18- second temperature control jacket; 19- fourth control valve; 20- PAT online monitor; 21-first pressure gauge; 22-second pressure gauge; 23-fifth control valve; 24-sixth control valve; 25-eighth pipeline; 26-eighth control valve; 28-collection return air filter; 29-organic solvent collection tank; 30-discharge main control valve; 31-seventh control valve; 32-first temperature control jacket; 33-temperature controller; 34-stirring mechanism; 35-opening valve; 36-air outlet pipeline; 37-ninth control valve. DETAILED DESCRIPTION

[0022] Embodiment 1: Please refer to Figure 1The present embodiment is a low-temperature freezing vacuum drying system 200 for continuous dynamic production, which includes a vacuum drying chamber 1, a discharge buffer chamber 2 arranged at the bottom of the vacuum drying chamber 1, a vacuum filter 4 connected to the vacuum drying chamber 1 through a first pipeline 3, a vacuum pump group 6 connected to the vacuum filter 4 through a second pipeline 5, a material collector 8 connected to the bottom of the discharge buffer chamber 2 through a third pipeline 7, and an induced draft fan 10 connected to the top of the material collector 8 through a fourth pipeline 9, and the bottom of the vacuum filter 4 is connected to the material collector through a fifth pipeline 11. 8 is connected, and the blowing side of the induced draft fan 10 is connected to the top of the vacuum filter 4 through the sixth pipeline 12; the vacuum pump group 6 performs vacuum extraction inside the vacuum drying chamber 1 through the second pipeline 5, the vacuum filter 4 and the first pipeline 3; the induced draft fan 10, on the one hand, generates negative pressure in the material collector 8 through the fourth pipeline 9, and draws the material in the discharge buffer chamber 2 into the material collector 8 through the third pipeline 7; on the other hand, the material adsorbed in the vacuum filter 4 is blown back through the sixth pipeline 12 and blown into the material collector 8 through the fifth pipeline 11.

[0023] The top of the vacuum drying chamber 1 is provided with a feed port 13 and a vacuum interface (not marked in the figure), and the bottom is provided with a discharge port (not marked in the figure); the discharge buffer chamber 2 is arranged below the discharge port and docked with the bottom of the vacuum drying chamber 1, and the discharge port is provided with a first control valve 14 for controlling the opening or closing of the discharge port. One end of the first pipeline 3 is connected to the vacuum interface and the other end is connected to the vacuum filter 4. The feed port 13 is connected to the material feeding system, and a control valve for controlling the opening and closing is provided on the pipeline connected to the feed port 13. A breathing valve (not marked in the figure) is also provided on the vacuum drying chamber 1, which is used for vacuum pressure relief of the vacuum drying chamber 1 and converting the vacuum pressure environment into a normal pressure environment.

[0024] The outer surface of the vacuum drying chamber 1 is covered with a first temperature control jacket 32 ​​, and the first temperature control jacket 32 ​​is connected to a temperature controller 33 . The temperature of the circulating medium inside the first temperature control jacket 32 ​​is controlled by the temperature controller 33 to cool or heat the vacuum drying chamber 1 .

[0025] A stirring mechanism 34 is provided in the vacuum drying chamber 1 , and the stirring mechanism 34 is used to stir the material in the vacuum drying chamber 1 in a spiral manner by rolling up and down.

[0026] The first pipeline 3 is provided with a second control valve 15 for controlling the opening and closing of the first pipeline 3, and controls the conduction and blocking between the vacuum drying chamber 1 and the vacuum filter 4. The second pipeline 5 is provided with a third control valve 16 for controlling the opening and closing of the second pipeline 5, and a vacuum gauge 17 for monitoring the vacuum degree in the second pipeline 5. The conduction and blocking between the vacuum filter 4 and the vacuum pump group 6 are controlled by the third control valve 16. The vacuum degree in the second pipeline 5 is monitored by the vacuum gauge 17, and the start and stop of the vacuum pump group 6 can be controlled according to the process requirements.

[0027] The outer peripheral surface of the vacuum filter 4 is covered with a second temperature control jacket 18. When the dryness of the material adsorbed in the vacuum filter 4 is not enough, the second temperature control jacket 18 can be opened to heat and dry the material in the vacuum filter 4.

[0028] The third pipeline 7 is provided with a fourth control valve 19 for controlling the opening and closing of the third pipeline 7 and a PAT online monitor 20 for monitoring the set parameters of the material in the third pipeline 7. The PAT online monitor 20 can monitor the concentration, temperature, dryness, composition, etc. of the material in the third pipeline 7 as required. The conduction and blocking between the discharge buffer chamber 2 and the material collector 8 are controlled by the fourth control valve 19.

[0029] The sixth pipeline 12 is provided with a first pressure gauge 21 for monitoring the pressure in the sixth pipeline 12. The fourth pipeline 9 is provided with a second pressure gauge 22 for monitoring the pressure in the fourth pipeline 9.

[0030] The fifth pipeline 11 is provided with a fifth control valve 23 for controlling the opening and closing of the fifth pipeline 11. The conduction and blocking between the vacuum filter 4 and the material collector 8 are controlled by the fifth control valve 23. The fifth pipeline 11 and the third pipeline 7 are connected to the material collector 8 after merging into the seventh pipeline (not shown in the figure), and the sixth control valve 24 for controlling the opening and closing of the seventh pipeline is provided. The sixth control valve 24 controls the switching of the opening and closing state of the input port of the material collector 8.

[0031] The sixth pipeline 12 is provided with a seventh control valve 31 for controlling the opening and closing of the sixth pipeline 12 , and the conduction and blocking between the vacuum filter 4 and the induced draft fan 10 are controlled by the seventh control valve 31 .

[0032] The air outlet side of the induced draft fan 10 is connected to the discharge buffer chamber 2 via the eighth pipeline 25, and the eighth control valve 26 is provided on the eighth pipeline 25. The eighth pipeline 25 is used as the air outlet pipeline of the induced draft fan 10 and is connected to the discharge buffer chamber 2 at the same time, forming a closed internal circulation system to ensure that the material is isolated from the outside world during the internal pipeline transfer process to prevent contamination, and also prevent the material from leaking and affecting the workshop environment. The output side of the induced draft fan 10 is also provided with an air outlet pipeline 36 connected to the outside world, and a ninth control valve 37 is provided on the air outlet pipeline 36. The air outlet pipeline 36 can be opened when the pipeline inside the vacuum drying system needs to be dried after cleaning.

[0033] When drying the internal pipeline, two drying paths are included; one of the drying paths is: the outside air enters the vacuum drying chamber 1 from the feed port 13, and then passes through the first pipeline 3, the vacuum filter 4, the fifth pipeline 11, the material collector 8, and the fourth pipeline 9, and is discharged from the air outlet pipeline 36 under the suction of the induced draft fan 10; the other drying path is: the outside air enters the vacuum drying chamber 1 from the feed port 13, and then passes through the discharge buffer chamber 2, the third pipeline 7, the material collector 8, and the fourth pipeline 9, and is discharged from the air outlet pipeline 36 under the suction of the induced draft fan 10.

[0034] The fourth pipeline 9 is also provided with a return air filter 28 to filter out gas and liquid in the air in the fourth pipeline 9 to prevent the gas and liquid from entering the induced draft fan 10 and damaging the induced draft fan 10 .

[0035] An organic solvent collecting tank 29 is also provided on the air outlet side of the vacuum pump group 6 .

[0036] A discharge main control valve 30 is provided at the bottom of the material collector 8 .

[0037] The bottom of the discharge buffer chamber 2 is provided with a discharge port, and the discharge port is provided with an opening valve 35. The opening valve 35 can be opened and used when rapid discharge is required during cleaning, equipment failure or abnormal conditions.

[0038] The production method of a low-temperature freeze-drying system for continuous dynamic production in this embodiment comprises the following steps: S1, feeding: in the initial state, all control valves are in the closed state, and the feed liquid enters the vacuum drying chamber 1 through the feed port 13 to realize automatic feeding. When the feed reaches the set amount, the control valve at the feed port 13 is closed; S2, low-temperature stirring: the temperature controller 33 controls the temperature of the first temperature control jacket 32 ​​to cool the vacuum drying chamber 1, and at the same time, the stirring mechanism 34 stirs the material at a set speed until the material liquid is stirred and frozen into the required ice particles at low temperature; S3, vacuum sublimation drying: the second control valve 15 and the third control valve 16 are opened, the vacuum pump group 6 starts to work, the vacuum drying chamber 1 is evacuated, the stirring mechanism 34 maintains the stirring state, and at the same time, the temperature controller 33 controls the temperature of the first temperature control jacket 32 ​​to heat the vacuum drying chamber 1 until the material in the vacuum drying chamber 1 becomes the desired powder; S4, unloading: including quick unloading of vacuum drying chamber 1 and process unloading of vacuum filter 4, the two unloading processes are carried out in sequence, but there is no strict order, or vacuum filter 4 performs process unloading only after vacuum drying chamber 1 completes a set number of quick unloading; wherein, There are two ways to quickly unload the vacuum drying chamber 1: Method 1: The breathing valve on the vacuum drying chamber 1 is opened, the vacuum is released, and after the pressure in the chamber is restored to normal, the first control valve 14, the fourth control valve 19, the sixth control valve 24 and the seventh control valve 31 are opened, the third control valve 16 is closed, the second control valve 15 remains open, and the induced draft fan 10 is started. Under the action of the induced draft fan 10, on the one hand, positive pressure blowing force is applied to the inside of the vacuum drying chamber 1, and on the other hand, negative pressure suction force is formed in the discharge buffer chamber 2, so that the powder in the vacuum drying chamber 1 is quickly brought into the discharge buffer chamber 2. After the end, the first control valve 14 is closed; Method 2: The breathing valve on the vacuum drying chamber 1 is opened to release the vacuum. After the pressure in the chamber returns to normal, the first control valve 14, the fourth control valve 19, the sixth control valve 24 and the eighth control valve 26 are opened, the second control valve 15 and the third control valve 16 are closed, and the induced draft fan 10 is started. Under the action of the induced draft fan 10, a negative pressure suction force is formed in the discharge buffer chamber 2, and the powder in the vacuum drying chamber 1 is quickly drawn into the discharge buffer chamber 2. After the end, the first control valve 14 is closed to complete the rapid unloading of the material in the vacuum drying chamber 1; Discharging of the vacuum filter 4: the second control valve 15 and the third control valve 16 are closed, the fifth control valve 23, the sixth control valve 24 and the seventh control valve 31 are opened, the induced draft fan 10 is started, and the powder material collected in the vacuum filter 4 during the vacuuming process is blown back into the material collector 8. After the discharge, the fifth control valve 23 and the seventh control valve 31 are closed; When the vacuum drying chamber 1 is evacuated, the steam flow will carry part of the liquid feed into the vacuum filter 4, which will be intercepted by the vacuum filter 4, and the liquid feed will be heated by the second temperature control jacket 18 on the outer periphery of the vacuum filter 4 to obtain powder by drying. When the liquid feed in the vacuum drying chamber 1 is completely dried into powder, the second control valve 15 and the third control valve 16 are closed to isolate the vacuum filter 4 from the vacuum drying chamber 1 and the vacuum pump group 6, and the fifth control valve 23, the sixth control valve 24 and the seventh control valve 31 are opened to connect the induced draft fan 10, the vacuum filter 4 and the material collector 8. The process material collected by the vacuum filter 4 can be blown into the material collector 8 by the induced draft fan 10 to realize the unloading of the process material. On the one hand, the automatic unloading of the process material is realized, and on the other hand, the process material is effectively prevented from being heated in the vacuum filter 4 for too long to affect the activity of the drug.

[0039] S5, discharging: the fourth control valve 19, the sixth control valve 24 and the eighth control valve 26 are kept in the open state, the induced draft fan 10 is kept in the working state, all the materials in the discharging buffer chamber 2 are pumped into the material collector 8, and then the fourth control valve 19, the sixth control valve 24 and the eighth control valve 26 are closed, and the discharging master control valve 30 at the bottom of the material collector 8 is opened to carry out online continuous discharging. The discharging and packaging operations such as bottling and bagging can be carried out at the output end of the discharging master control valve 30; S6, continuous production of new materials: while step S5 is being executed, new liquid feed enters the vacuum drying chamber 1 through the feed port 13 to complete the feeding of new materials, and steps S2 to S4 are repeated to complete the vacuum freeze drying of the new materials, thereby achieving efficient and continuous production.

[0040] In this embodiment, the vacuum drying chamber 1, the first pipeline 3, the vacuum filter 4, the second pipeline 5 and the vacuum pump group 6 together form a vacuum freeze-drying production system; the discharge buffer chamber 2, the third pipeline 7, the material collector 8, the fourth pipeline 9 and the induced draft fan 10 together form a main unloading system; the vacuum filter 4, the fifth pipeline 11, the material collector 8, the fourth pipeline 9, the induced draft fan 10 and the sixth pipeline 12 together form a secondary unloading system; when the powder in the vacuum drying chamber 1 and the powder in the vacuum filter 4 are all unloaded, closing the first control valve 14, the fifth control valve 23, and the seventh control valve 31 can ensure the independence of the vacuum freeze-drying production system, and then during the discharging process, the vacuum freeze-drying production system can simultaneously carry out vacuum freeze-drying production of new material liquid, which greatly reduces the discharging waiting time, realizes continuous production, and improves production efficiency.

[0041] The entire material drying process, unloading process and discharging process of this embodiment are completed in a closed pipeline system, without the need for external crushing work, which also reduces the contact between powder and the outside air, improves product quality, and at the same time reduces the cleanliness requirements for the production workshop and reduces production costs.

[0042] The above are only some embodiments of the present invention. For those skilled in the art, several modifications and improvements can be made without departing from the creative concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A low-temperature freeze-drying system for continuous dynamic production, characterized in that: include: A vacuum freeze-drying production system, the vacuum freeze-drying production system comprising a vacuum drying chamber (1), a vacuum filter (4) connected to the vacuum drying chamber (1) via a first pipeline (3), and a vacuum pump group (6) connected to the vacuum filter (4) via a second pipeline (5); a second control valve (15) is provided on the first pipeline (3), and a third control valve (16) is provided on the second pipeline (5); A main unloading system, the main unloading system comprising a discharge buffer chamber (2), a material collector (8) connected to the bottom of the discharge buffer chamber (2) via a third pipeline (7), and an induced draft fan (10) connected to the top of the material collector (8) via a fourth pipeline (9); the discharge buffer chamber (2) is docked and arranged at the bottom of the vacuum drying chamber (1); a fourth control valve (19) is arranged on the third pipeline (7); A secondary unloading system, the secondary unloading system comprising the vacuum filter (4), the material collector (8), the induced draft fan (10), a fifth pipeline (11) connecting the vacuum filter (4) and the material collector (8), the fourth pipeline (9), and a sixth pipeline (12) connecting the induced draft fan (10) and the vacuum filter (4); a fifth control valve (23) is provided on the fifth pipeline (11), and a seventh control valve (31) is provided on the sixth pipeline (12); A first control valve (14) is provided at the bottom of the vacuum drying chamber (1) to control the connection and disconnection between the vacuum drying chamber (1) and the discharge buffer chamber (2).

2. The low-temperature freeze-drying system for continuous dynamic production according to claim 1, characterized in that: The top of the vacuum drying chamber (1) is provided with a feed port (13) and a vacuum extraction interface, and the bottom is provided with a discharge port; the discharge buffer chamber (2) is arranged below the discharge port and docked with the bottom of the vacuum drying chamber (1), and the first control valve (14) is arranged at the discharge port; one end of the first pipeline (3) is connected to the vacuum extraction interface; the feed port (13) is connected to a material feeding system, and a control valve for controlling opening and closing is arranged on the pipeline connected to the feed port (13).

3. The low-temperature freeze-drying system for continuous dynamic production according to claim 1, characterized in that: The outer peripheral surface of the vacuum drying chamber (1) is covered with a first temperature control jacket (32), and the first temperature control jacket (32) is electrically connected to a temperature controller; a stirring mechanism (34) is provided inside the vacuum drying chamber (1).

4. The low-temperature freeze-drying system for continuous dynamic production according to claim 1, characterized in that: The second pipeline (5) is provided with a vacuum gauge (17) for monitoring the vacuum degree in the second pipeline (5).

5. The low-temperature freeze-drying system for continuous dynamic production according to claim 1, characterized in that: The outer peripheral surface of the vacuum filter (4) is covered with a second temperature control jacket (18).

6. The low-temperature freeze-drying system for continuous dynamic production according to claim 1, characterized in that: The third pipeline (7) is provided with a PAT online monitor (20) for monitoring set parameters of the material in the third pipeline (7).

7. The low-temperature freeze-drying system for continuous dynamic production according to claim 1, characterized in that: The sixth pipeline (12) is provided with a first pressure gauge (21) for monitoring the pressure in the sixth pipeline (12); the fourth pipeline (9) is provided with a second pressure gauge (22) for monitoring the pressure in the fourth pipeline (9).

8. The low-temperature freeze-drying system for continuous dynamic production according to claim 1, characterized in that: The fifth pipeline (11) and the third pipeline (7) converge into the seventh pipeline and are then connected to the material collector (8), and a sixth control valve (24) is provided on the seventh pipeline to control its opening and closing.

9. The low-temperature freezing vacuum drying system for continuous dynamic production according to claim 1, characterized in that: The air outlet side of the induced draft fan (10) is connected to the discharge buffer chamber (2) via an eighth pipeline (25), and an eighth control valve (26) is provided on the eighth pipeline (25).

10. The low-temperature freeze-drying system for continuous dynamic production according to claim 1, characterized in that: The fourth pipeline (9) is also provided with a return air collection filter (28).

11. The low-temperature freeze-drying system for continuous dynamic production according to claim 1, characterized in that: A discharge master control valve (30) is provided at the bottom of the material collector (8); a discharge port is provided at the bottom of the discharge buffer chamber (2), and an opening valve (35) is provided at the discharge port.

12. A production method based on the low-temperature freeze vacuum drying system of continuous dynamic production according to claim 9, characterized in that: The following steps are involved: S1, feeding: in the initial state, all control valves are in a closed state, and the feed liquid enters the vacuum drying chamber (1) to achieve automatic feeding; S2, low-temperature stirring: cooling the vacuum drying chamber (1) and stirring the material at the same time, until the material liquid is stirred at low temperature and frozen into the required ice particles; S3, vacuum sublimation drying: the second control valve (15) and the third control valve (16) are opened, the vacuum pump group (6) starts to work, evacuates the vacuum drying chamber (1), maintains a stirring state, and at the same time, heats the vacuum drying chamber (1) until the material in the vacuum drying chamber (1) turns into the desired powder; S4, unloading: including rapid unloading of the vacuum drying chamber, quickly unloading the powder in the vacuum drying chamber (1) into the discharge buffer chamber (2); The vacuum drying chamber is quickly unloaded by method 1 or method 2; The first method is as follows: the vacuum drying chamber (1) is vented, and after the pressure in the chamber returns to normal, the first control valve (14), the fourth control valve (19), the sixth control valve (24) and the seventh control valve (31) are opened, the third control valve (16) is closed, the second control valve (15) remains in an open state, the induced draft fan (10) is started, and under the action of the induced draft fan (10), the powder in the vacuum drying chamber (1) is quickly brought into the discharge buffer chamber (2), and after completion, the first control valve (14) is closed; The second method is as follows: the vacuum drying chamber (1) is vented, and after the pressure in the chamber returns to normal, the first control valve (14), the fourth control valve (19), the sixth control valve (24) and the eighth control valve (26) are opened, the second control valve (15) and the third control valve (16) are closed, and the induced draft fan (10) is started. Under the action of the induced draft fan (10), the powder in the vacuum drying chamber (1) is quickly brought into the discharge buffer chamber (2), and after completion, the first control valve (14) is closed; S5, discharging: the fourth control valve (19), the sixth control valve (24) and the eighth control valve (26) are kept in an open state, the induced draft fan (10) is kept in an operating state, all the materials in the discharging buffer chamber (2) are pumped into the material collector (8), and then the fourth control valve (19), the sixth control valve (24) and the eighth control valve (26) are closed, and the main discharging control valve (30) at the bottom of the material collector (8) is opened to discharge the materials; S6, continuous production of new materials: while step S5 is being executed, new liquid feed enters the vacuum drying chamber (1) through the feed port (13) to complete the feeding of new materials, and steps S2 to S4 are repeated to complete the vacuum freeze drying of the new materials, thereby achieving efficient continuous production.

13. The method for producing a low-temperature freeze-vacuum drying system according to claim 1, characterized in that: The step S4 also includes vacuum filter process unloading; The vacuum filter process unloading includes: the second control valve (15) and the third control valve (16) are closed, the fifth control valve (23), the sixth control valve (24) and the seventh control valve (31) are opened, the induced draft fan (10) is started, and the powder material collected in the vacuum filter (4) during the vacuuming process is blown back into the material collector (8), and the fifth control valve (23) and the seventh control valve (31) are closed after completion.

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