Special bacteriostatic agent for eczematous dermatitis and atopic dermatitis

Abstract

The invention discloses a special bacteriostatic agent for eczematous dermatitis and atopic dermatitis, which belongs to the technical field of bacteriostatic agents, and comprises the following raw materials: fructus forsythiae, rhizoma atractylodis, rheum officinale, schizonepeta spike, cortex dictamni, fructus kochiae, radix sophorae flavescentis, deionized water, propylene glycol, chlorhexidine diacetate, sodium hyaluronate, betaine, ammonium acryloyldimethyl taurate / VP copolymer, 1, 3-propylene glycol, 1, 3-propylene glycol, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium According to the formula, 1, 2-hexanediol, capryloyl hydroximic acid, glyceryl stearate, PEG-100 stearate, cetostearyl alcohol, polydimethylsiloxane, squalane, isononyl isononanoate and butanediol are adopted, all the raw materials in the formula are low-irritation or non-irritation substances, the formula is mild to human skin, anaphylactic reaction or other side effects cannot be generated, the product is in a paste shape, and the skin care effect is good. And most of the raw materials are derived from natural plants, are environmentally friendly, and accord with the principle of green chemistry.

Description

Technical Field

[0001] The invention belongs to the technical field of antibacterial agents, and in particular relates to an antibacterial agent specifically for dermatitis, eczema and atopic dermatitis. Background Art

[0002] In modern life, due to environmental pollution, life pressure and other factors, the incidence of skin problems such as dermatitis, eczema and atopic dermatitis is increasing. These skin problems not only bring physical discomfort to patients, but also seriously affect the quality of life of patients.

[0003] There are various products for treating these skin problems on the market, but they cannot simultaneously meet the requirements of antibacterial (the increase of Staphylococcus aureus in patients with dermatitis, eczema and atopic dermatitis seriously affects treatment), antipruritic, moisturizing, and barrier repair. Many products are not only costly but also may have side effects on the human body due to their complex ingredients. Therefore, developing a safe and effective treatment product is an important task at present. For this reason, we propose a special antibacterial agent for dermatitis, eczema and atopic dermatitis to solve the above problems. Summary of the invention

[0004] The object of the present invention is to provide a special antibacterial agent for dermatitis, eczema and atopic dermatitis to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a special antibacterial agent for dermatitis, eczema and atopic dermatitis, characterized in that it comprises the following raw materials: forsythia, atractylodes, rhubarb, schizonepeta spicate, dittany bark, kochia scoparia, sophora flavescens, deionized water, propylene glycol, chlorhexidine diacetate, sodium hyaluronate, betaine, ammonium acryloyldimethyltaurate / VP copolymer, 1,3-propylene glycol, 1,2-hexanediol, caprylhydroxamic acid, glyceryl stearate, PEG-100 stearate, cetearyl alcohol, polydimethylsiloxane, squalane, isononyl isononanoate and butylene glycol.

[0006] Preferably, a process for preparing an antibacterial agent comprises the following steps:

[0007] (1) Preparation

[0008] A. Add 1-2g of Fructus Forsythiae, 1-2g of Rhizoma Atractylodis Macrocephalae, 1-2g of Radix Rhei, 2-4g of Spike of Schizonepeta, 2-4g of Cortex Dictamni, 2-4g of Fructus Kochiae, and 2-4g of Radix Sophorae Flavescentis to an extraction tank, add 100g of deionized water, soak for 1 hour, heat, boil for 1 hour, and after cooling, use 100 mesh coarse filtration and 400 mesh fine filtration for standby use to obtain mixed solution A50-85g;

[0009] B1, 1.0-8.0 g of propylene glycol, 0.05-0.3 g of chlorhexidine diacetate and 1.0-8.0 g of butylene glycol are mixed uniformly to obtain a standby mixed solution B1;

[0010] B2, 0.01-0.2 g of sodium hyaluronate, 0.5-3.0 g of betaine and 0.1-3.0 g of ammonium acryloyldimethyltaurate / VP copolymer are mixed evenly to obtain a mixed solution B2 for standby use;

[0011] C. Mix 0.1-3.5 g of glyceryl stearate, 0.1-3.5 g of PEG-100 stearate, 0.2-6.0 g of cetearyl alcohol, 0.5-5.0 g of polydimethylsiloxane, 0.5-10.0 g of squalane and 0.5-10.0 g of isononyl isononanoate to obtain a mixed solution C for standby use;

[0012] D. Evenly mix 0.1-5.0 g of 1,3-propylene glycol, 0.1-5.0 g of 1,2-hexanediol and 0.01-2.0 g of octanoylhydroxamic acid to obtain a mixed solution D for standby use.

[0013] (2) Mixing

[0014] Add A to the main pot, add B2 in turn, heat to 80-85℃, stir evenly, and keep warm for 30-60 minutes;

[0015] Add C to the auxiliary pot, stir and heat to 80-85℃;

[0016] Add the materials in the auxiliary pot to the main pot, stir quickly, and vacuum homogenize for 3-5 minutes (homogenizing speed 3000-5000 rpm). After homogenization, keep vacuuming and stirring slowly to keep warm for 30-60 minutes;

[0017] When the temperature drops to 35-40℃ while stirring continuously, add B1 and D and stir evenly.

[0018] (3) Submission for inspection

[0019] Take samples and send them to the laboratory to test the appearance, smell, pH and other indicators.

[0020] (4) Bottling

[0021] Dispense the product into vials and seal them.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] All raw materials are low-irritant or non-irritating substances, which are gentle to human skin and will not cause allergic reactions or other side effects. The product is in liquid form, easy to apply and absorb, and does not require professional operation. It is suitable for family self-care. Most of the raw materials are derived from natural plants, which are environmentally friendly and in line with the principles of green chemistry. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] The invention provides a special antibacterial agent for dermatitis, eczema and atopic dermatitis, which is characterized by comprising the following raw materials: forsythia, atractylodes, rhubarb, schizonepeta spicate, dittany bark, kochia scoparia, sophora flavescens, deionized water, propylene glycol, chlorhexidine diacetate, sodium hyaluronate, betaine, ammonium acryloyldimethyltaurate / VP copolymer, 1,3-propylene glycol, 1,2-hexanediol, caprylhydroxamic acid, glyceryl stearate, PEG-100 stearate, cetearyl alcohol, polydimethylsiloxane, squalane, isononyl isononanoate and butylene glycol.

[0026] In this embodiment, a preparation process of a special antibacterial agent for dermatitis, eczema and atopic dermatitis includes the following steps:

[0027] (1) Preparation

[0028] A. Add 1-2g of Fructus Forsythiae, 1-2g of Rhizoma Atractylodis Macrocephalae, 1-2g of Radix Rhei, 2-4g of Spike of Schizonepeta, 2-4g of Cortex Dictamni, 2-4g of Fructus Kochiae, and 2-4g of Radix Sophorae Flavescentis to an extraction tank, add 100g of deionized water, soak for 1 hour, heat, boil for 1 hour, and after cooling, use 100 mesh coarse filtration and 400 mesh fine filtration for standby use to obtain mixed solution A50-85g;

[0029] B1, 1.0-8.0 g of propylene glycol, 0.05-0.3 g of chlorhexidine diacetate and 1.0-8.0 g of butylene glycol are mixed uniformly to obtain a standby mixed solution B1;

[0030] B2, 0.01-0.2 g of sodium hyaluronate, 0.5-3.0 g of betaine and 0.1-3.0 g of ammonium acryloyldimethyltaurate / VP copolymer are mixed evenly to obtain a mixed solution B2 for standby use;

[0031] C. Mix 0.1-3.5 g of glyceryl stearate, 0.1-3.5 g of PEG-100 stearate, 0.2-6.0 g of cetearyl alcohol, 0.5-5.0 g of polydimethylsiloxane, 0.5-10.0 g of squalane and 0.5-10.0 g of isononyl isononanoate to obtain a mixed solution C for standby use;

[0032] D. Evenly mix 0.1-5.0 g of 1,3-propylene glycol, 0.1-5.0 g of 1,2-hexanediol and 0.01-2.0 g of octanoylhydroxamic acid to obtain a mixed solution D for standby use.

[0033] (2) Mixing

[0034] Add A to the main pot, add B2 in turn, heat to 80-85℃, stir evenly, and keep warm for 30-60 minutes;

[0035] Add C to the auxiliary pot, stir and heat to 80-85℃;

[0036] Add the materials in the auxiliary pot to the main pot, stir quickly, and vacuum homogenize for 3-5 minutes (homogenizing speed 3000-5000 rpm). After homogenization, keep vacuuming and stirring slowly to keep warm for 30-60 minutes;

[0037] When the temperature drops to 35-40℃ while stirring continuously, add B1 and D and stir evenly.

[0038] (3) Submission for inspection

[0039] Take samples and send them to the laboratory to test the appearance, smell, pH and other indicators.

[0040] (4) Bottling

[0041] Dispense the product into vials and seal them.

[0042] Further:

[0043] Forsythia: It has the effects of clearing away heat and detoxifying, reducing swelling and relieving pain, and has a good therapeutic effect on dermatitis, eczema and atopic dermatitis.

[0044] Atractylodes: It has the effects of drying dampness and promoting diuresis, reducing swelling and dispersing nodules. It has a certain therapeutic effect on skin diseases such as eczema and dermatitis.

[0045] Rhubarb: It has the effects of clearing away heat and purging fire, cooling blood and detoxifying, and has a good therapeutic effect on heat-toxic dermatitis and eczema.

[0046] Schizonepeta Spike: It has the effects of dispelling wind and cold, relieving exterior symptoms and dissipating heat, and has a certain therapeutic effect on wind-cold dermatitis and eczema.

[0047] Dactylic acid: It has the effects of clearing away heat and detoxifying, cooling blood and relieving itching, and has a good therapeutic effect on skin diseases such as dermatitis and eczema.

[0048] Kochia scoparia: It has the effects of clearing away heat and detoxifying, cooling blood and relieving itching, and has a good therapeutic effect on skin diseases such as dermatitis and eczema.

[0049] Sophora flavescens: It has the effects of clearing away heat and detoxifying, drying dampness and relieving itching, and has a good therapeutic effect on skin diseases such as dermatitis and eczema.

[0050] Deionized water: used as a solvent to extract and mix various pharmaceutical ingredients.

[0051] Propylene glycol: acts as a humectant and solvent to increase the moisturizing properties and stability of the product.

[0052] Chlorhexidine diacetate: It has antibacterial and anti-inflammatory effects, and has a good therapeutic effect on skin diseases such as dermatitis and eczema.

[0053] Sodium hyaluronate: It has the function of moisturizing and nourishing the skin, improving symptoms such as dry and rough skin.

[0054] Betaine: It has moisturizing and anti-irritation effects, and has a good auxiliary therapeutic effect on skin diseases such as dermatitis and eczema.

[0055] Ammonium Acryloyldimethyltaurate / VP Copolymer: acts as a stabilizer and thickener to improve the stability and feel of the product.

[0056] 1,3-Propanediol: As a solvent and humectant, it increases the moisturizing property and stability of the product.

[0057] 1,2-Hexanediol: As a solvent and humectant, it increases the moisturizing property and stability of the product.

[0058] Caprylhydroxamic acid: It has antibacterial and anti-inflammatory effects, and has a good therapeutic effect on skin diseases such as dermatitis and eczema.

[0059] Glyceryl Stearate: As an emulsifier and stabilizer, it improves the stability and feel of the product.

[0060] PEG-100 Stearate: acts as an emulsifier and stabilizer to improve the stability and feel of the product.

[0061] Cetearyl Alcohol: acts as an emulsifier and stabilizer to improve the stability and feel of the product.

[0062] Polydimethylsiloxane: acts as a lubricant and water-repellent to improve the lubricity and water-repellency of the product.

[0063] Squalane: It has the function of moisturizing, nourishing the skin, repairing the skin barrier, and improving symptoms such as dry and rough skin.

[0064] Isononyl Isononanoate: acts as an emulsifier and stabilizer to improve the stability and feel of the product.

[0065] Butylene glycol: acts as a solvent and humectant to increase the moisturizing property and stability of the product.

[0066] The working principle and use process of the present invention:

[0067] 1-2g of Forsythia suspensa, 1-2g of Atractylodes lancea, 1-2g of Rhubarb, 2-4g of Nepeta spicate, 2-4g of Dictamni cortex, 2-4g of Kochia scoparia, and 2-4g of Sophora flavescens were added to an extraction tank, 100g of deionized water was added to the extraction tank, and the mixture was soaked for 1 hour. The extraction tank was heated to boiling and continued to boil for 1 hour. The extract was cooled to room temperature, and coarsely filtered through a 100-mesh filter, and then finely filtered through a 400-mesh filter to obtain 50-85g of a mixed solution A for standby use. 1.0-8.0g of propylene glycol, 0.05-0.3g of chlorhexidine diacetate, and butylene glycol were mixed in a container. In another container, 0.01-0.2 g of sodium hyaluronate, 0.5-3.0 g of betaine and 0.1-3.0 g of ammonium acryloyldimethyltaurate / VP copolymer were mixed to obtain a standby mixed solution B2. In a third container, 0.1-3.0 g of glyceryl stearate, 0.1-3.0 g of PEG-100 stearate, 0.5-5.0 g of cetearyl alcohol, 0.5-5.0 g of polydimethylsiloxane, 0.5-10.0 g of squalane and 0.5-10.0 g of isononyl isononanoate were mixed. 10.0g to obtain a standby mixed solution C, mix 0.1-5.0g of 1,3-propylene glycol, 0.1-5.0g of 1,2-hexanediol and 0.01-2.0g of octanoylhydroxamic acid in a fourth container to obtain a standby mixed solution D, add the mixed solution A to the main pot, add the standby mixed solution B2, heat the main pot to 80-85°C, and stir at this temperature for 30-60 minutes, add the standby mixed solution C to the auxiliary pot, and heat it to 80-85°C, add the materials in the auxiliary pot to the main pot, stir rapidly, and homogenize under vacuum for 3-5 minutes (homogenization speed 3000-5000 rpm), after homogenization, maintain vacuum and stir slowly for 30-60 minutes, continue stirring to cool down to 35-40℃, then add the reserved mixed liquid B1 and D, stir evenly, take samples from the main pot, send the samples to the laboratory for inspection of appearance, smell, pH and other indicators, ensure that the product has passed all necessary quality tests, put the final product into pre-prepared bottles, ensure that the bottles are well sealed, mark product information such as production date, expiration date, etc., store the products under appropriate conditions, and wait for further distribution or sales.

[0068] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A special antibacterial agent for dermatitis, eczema and atopic dermatitis, characterized in that: The ingredients include: Forsythia suspensa, Atractylodes lancea, Rhubarb, Nepeta tenuifolia, Dictamni cortex, Kochia scoparia, Sophora flavescens, deionized water, propylene glycol, chlorhexidine diacetate, sodium hyaluronate, betaine, ammonium acryloyldimethyltaurate / VP copolymer, 1,3-propylene glycol, 1,2-hexanediol, caprylhydroxamic acid, glyceryl stearate, PEG-100 stearate, cetearyl alcohol, dimethicone, squalane, isononyl isononanoate and butylene glycol. The preparation process of the special antibacterial agent for dermatitis, eczema and atopic dermatitis comprises the following steps: (1) Preparation A. Add 1-2g of Fructus Forsythiae, 1-2g of Rhizoma Atractylodis Macrocephalae, 1-2g of Radix Rhei, 2-4g of Spike of Schizonepeta, 2-4g of Cortex Dictamni, 2-4g of Fructus Kochiae, and 2-4g of Radix Sophorae Flavescentis to an extraction tank, add 100g of deionized water, soak for 1 hour, heat, boil for 1 hour, and after cooling, use 100 mesh coarse filtration and 400 mesh fine filtration for standby use to obtain mixed solution A50-85g; B1, 1.0-8.0 g of propylene glycol, 0.05-0.3 g of chlorhexidine diacetate and 1.0-8.0 g of butylene glycol are mixed to obtain a mixed solution B1 for standby use; B2, 0.01-0.2 g of sodium hyaluronate, 0.5-3.0 g of betaine and 0.1-3.0 g of ammonium acryloyldimethyltaurate / VP copolymer are mixed evenly to obtain a mixed solution B2 for standby use; C. Mix 0.1-3.5 g of glyceryl stearate, 0.1-3.5 g of PEG-100 stearate, 0.2-6.0 g of cetearyl alcohol, 0.5-5.0 g of polydimethylsiloxane, 0.5-10.0 g of squalane and 0.5-10.0 g of isononyl isononanoate to obtain a mixed solution C for standby use; D. Evenly mix 0.1-5.0 g of 1,3-propylene glycol, 0.1-5.0 g of 1,2-hexanediol and 0.01-2.0 g of octanoylhydroxamic acid to obtain a mixed solution D for standby use. (2) Mixing Add A to the main pot, add B2 in turn, heat to 80-85℃, stir evenly, and keep warm for 30-60 minutes; Add C to the auxiliary pot, stir and heat to 80-85℃; Add the materials in the auxiliary pot to the main pot, stir quickly, and vacuum homogenize for 3-5 minutes (homogenizing speed 3000-5000 rpm). After homogenization, keep vacuuming and stirring slowly to keep warm for 30-60 minutes. When the temperature drops to 35-40℃ while stirring continuously, add B1 and D and stir evenly. (3) Submission for inspection Take samples and send them to the laboratory to test the appearance, smell, pH and other indicators. (4) Bottling Dispense the product into vials and seal them.