Medical transparent dressing and preparation method thereof

Abstract

The invention discloses a manufacturing method of a medical transparent dressing, and relates to the technical field of medical instruments. S1, raw material preparation; s2, coating with an adhesive; s3, laser drilling is carried out; s4, hot-pressing and compounding; s5, surface modification; the laser drilling method comprises the following steps: 1, preparing materials; 2, equipment debugging; 3, programming and punching; and 4, processing after punching. The laser-beam drilling machine is used for manufacturing tiny holes in the adhesive layer of the medical transparent dressing to increase the permeation path of water vapor, the moisture permeability of the dressing is improved, the moisture permeability is remarkably improved on the premise that the strength and the stickiness of the dressing are guaranteed, the skin around a wound can be better breathed and moisturized, wound healing is promoted, and the wound healing rate is increased. No mechanical stress is applied to the material, deformation and damage of the material are avoided, the original performance and integrity of the medical acrylate adhesive layer can be kept, the consistency and stability of the dressing are guaranteed by accurately controlling the hole diameter and the hole distance, and the discomfort of a patient using the dressing is relieved.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, in particular to a medical transparent dressing and a manufacturing method thereof. Background Art

[0002] Medical transparent dressing is a transparent film dressing that can breathe with the skin. It is mainly made of highly permeable polyurethane film and special moisture-permeable medical acrylic adhesive through a special coating process. The dressing is sterilized with ethylene oxide and is a disposable sterile product. Medical transparent dressing has a wide range of uses in the medical field, including surgery, wound and incontinence care, monitoring, diagnosis and other aspects. It can be used in a variety of medical scenarios, such as fixing intravenous indwelling needles, fixing arteriovenous indwelling catheters, protecting wounds, etc.

[0003] The defects in the preparation of medical transparent dressings in the prior art are: 1. Patent document US11331406B2 discloses a medical dressing, which has fewer water vapor transmission paths and low moisture permeability. When the dressing is used, the skin around the wound cannot breathe and moisturize well, which increases the discomfort of the patient when using the dressing.

[0004] 2. Patent document CN116966013A discloses a method for preparing a main body material of a medical transparent dressing. The medical dressing prepared by this preparation method has fewer water vapor transmission paths and low moisture permeability. When the dressing is used, the skin around the wound cannot breathe and moisturize well, which increases the discomfort of the patient when using the dressing.

[0005] 3. Patent document CN218792763U discloses a multi-layer antibacterial dressing for central venous catheterization. The surface roughness and specific surface area of ​​the dressing are low, which is not conducive to the penetration of water vapor. The moisture permeability of the dressing is poor, thereby increasing skin irritation and rejection reactions, slowing down cell growth and repair, and shortening the service life of the medical transparent dressing.

[0006] 4. Patent document CN116421769A discloses an ultra-thin transparent dressing and its preparation method and application. The surface roughness and specific surface area of ​​the transparent dressing are low, which is not conducive to the penetration of water vapor. The moisture permeability of the dressing is poor, thereby increasing skin irritation and rejection reaction, slowing down cell growth and repair, and shortening the service life of the medical transparent dressing. Summary of the invention

[0007] The object of the present invention is to provide a medical transparent dressing and a method for making the same, so as to solve the problems raised in the above background technology.

[0008] To achieve the above object, the present invention provides the following technical solution: a method for making a medical transparent dressing, comprising the following steps: S1, raw material preparation; S2, adhesive coating; S3, laser drilling; S4, hot pressing and laminating; S5, surface modification; The laser drilling steps are as follows: 1. material preparation; 2. equipment debugging; 3. programming and drilling; 4. post-drilling processing.

[0009] Preferably, the raw material preparation steps are as follows: prepare a high-permeability polyurethane film, a hydrophilic material core, a polyurethane backing film, a medical acrylate adhesive and a release film base material.

[0010] Preferably, the adhesive coating step is as follows: a layer of medical acrylate adhesive is evenly coated on the surface of the high-permeability polyurethane film using a roller coater to ensure that the adhesive layer is uniform, smooth and of uniform thickness.

[0011] Preferably, the coating thickness of the medical acrylic adhesive is 8 to 15 μm.

[0012] Preferably, the laser drilling steps are as follows: Step 1 Material preparation: Place the high-permeability polyurethane film coated with medical acrylic adhesive on the workbench of the laser drilling machine to ensure that the surface is flat, clean and free of impurities; Step 2 Equipment debugging: Check whether the various functions of the laser drilling machine are normal, including the laser generator, focusing lens and control system, adjust the working parameters of the laser drilling machine, control the laser power at 5-10W, the pulse width at 0.2-1.0ms, the repetition frequency at 10-100KHz, and the scanning speed at 800-1200mm / s; Step 3 Programming and drilling: Write the control program of the laser drilling machine according to the shape and distribution of the holes to be punched, start the laser drilling machine, and drill according to the preset program. During the drilling process, the drilling effect should be closely monitored, and the parameters should be adjusted in time to ensure the quality and consistency of the holes; Step 4 Post-punching processing: After the drilling is completed, the high-permeability polyurethane film coated with medical acrylic adhesive is cleaned, the residue is removed and dried to ensure the cleanliness and smoothness of the holes.

[0013] Preferably, the hot pressing compounding steps are as follows: Step 1: adhesion preheating: adhere the release protective film to the outside of the high-permeability polyurethane film through medical acrylate adhesive, place the film coated with the adhesive layer and the backing film in a hot air oven respectively, ensure that the surface of the film is flat, without wrinkles or bubbles, and keep an appropriate distance from the surface of the preheating equipment to avoid overheating caused by direct contact, preheat at 60-80°C for 30-50s, and after preheating, take the film out of the preheating equipment and cool it naturally to room temperature; Step 2: laying and hot pressing: lay the release protective film, the high-permeability polyurethane film coated with medical acrylate adhesive, the hydrophilic material core, and the polyurethane backing film in order from bottom to top, use a hot press to compact the laid structure to ensure close contact between the structures, control the pressure at 10MPa-20MPa, and hot press at a constant temperature of 120°C for 40-50s, and then prepare the medical transparent dressing through cutting, wiring, and edge sealing.

[0014] Preferably, the surface modification step is as follows: placing the prepared medical transparent dressing in the treatment area of ​​the plasma treatment equipment, ensuring that the surface of the dressing is flat and completely exposed to the plasma, using an atmospheric pressure plasma jet device to perform plasma treatment on the medical transparent dressing. During the treatment process, the high-energy particles in the plasma will bombard the surface of the dressing to cause etching and activation changes on the surface, and the surface of the medical transparent dressing will have more -NH2 polar groups. The plasma reaction temperature is controlled at 120°C to 180°C, the plasma treatment time is 15s to 20s, and the dressing is taken out and cleaned and dried for post-treatment.

[0015] Preferably, the medical transparent dressing comprises a high-permeability polyurethane film, a hydrophilic material core, a polyurethane backing film, a medical acrylate adhesive layer and a release protective film, wherein the polyurethane backing film is arranged on the outside of the high-permeability polyurethane film, the hydrophilic material core is arranged between the high-permeability polyurethane film and the polyurethane backing film, the medical acrylate adhesive layer is arranged on the other side of the high-permeability polyurethane film, and the release protective film is arranged on the outside of the medical acrylate adhesive layer.

[0016] Compared with the prior art, the present invention has the following beneficial effects: 1. The present invention utilizes a laser puncher to create tiny holes on the adhesive layer of a medical transparent dressing to increase the permeation path of water vapor, ensure that the adhesive layer is evenly distributed on the film, and form an appropriate pore structure, which is conducive to the permeation of water vapor, improves the moisture permeability of the dressing, and significantly improves the moisture permeability while ensuring the strength and adhesion of the dressing, so that the skin around the wound can breathe and moisturize better, promote wound healing, and will not apply mechanical stress to the material, avoiding deformation and damage to the material, which is conducive to maintaining the original performance and integrity of the medical acrylic adhesive layer. The precise control of the pore size and hole spacing ensures the consistency and stability of the dressing, and reduces the discomfort of patients when using the dressing.

[0017] 2. After the preparation of the medical transparent dressing, the present invention uses plasma treatment to modify the surface of the dressing. Plasma treatment can form tiny pores or channels on the surface of the dressing. These groups can form hydrogen bonds with water molecules, increase the surface roughness and specific surface area, thereby facilitating the penetration of water vapor, improving the moisture permeability of the dressing, and maintaining a moist environment for the wound to promote wound healing. Plasma treatment changes the chemical composition and structure of the dressing surface, making it more hydrophilic, thereby reducing irritation and rejection reactions to the skin, improving biocompatibility, reducing wound infection, and promoting cell growth and repair. Plasma treatment forms a uniform film or coating on the surface of the dressing, thereby improving the safety, wear resistance and durability of the dressing and extending the service life of the medical transparent dressing. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 A process flow chart for making the medical transparent dressing of the present invention; Figure 2 It is a schematic diagram of the structure of the medical transparent dressing of the present invention.

[0019] In the figure: 1. High permeability polyurethane film; 2. Hydrophilic material core coating; 3. Polyurethane backing film; 4. Medical acrylate adhesive layer; 5. Release protective film. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front end", "rear end", "two ends", "one end", "the other end" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0022] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "provided with", "connected", etc. should be understood in a broad sense. For example, "connected" can be a fixed connection or a movable connection, or a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0023] Embodiment 1, an embodiment provided by the present invention: a medical transparent dressing and a method for making the same, the medical transparent dressing comprising a high-permeability polyurethane film 1, a hydrophilic material core 2, a polyurethane backing film 3, a medical acrylate adhesive layer 4 and a release protective film 5, the polyurethane backing film 3 is arranged on the outside of the high-permeability polyurethane film 1, the hydrophilic material core 2 is arranged between the high-permeability polyurethane film 1 and the polyurethane backing film 3, the medical acrylate adhesive layer 4 is arranged on the other side of the high-permeability polyurethane film 1, and the release protective film 5 is arranged on the outside of the medical acrylate adhesive layer 4; The manufacturing method of the medical transparent dressing comprises the following steps: S1, raw material preparation; S2, viscose coating; S3, hot pressing and compounding; The steps of preparing raw materials are as follows: preparing high-permeability polyurethane film, hydrophilic material core, polyurethane backing film, medical acrylate adhesive and release film base material; The adhesive coating steps are as follows: use a roller coater to evenly coat a layer of medical acrylate adhesive on the surface of the high-permeability polyurethane film to ensure that the adhesive layer is uniform, smooth and of uniform thickness. The coating thickness of the medical acrylate adhesive is 8 μm; The hot pressing and laminating steps are as follows: 1. Adhesion: adhere the release protective film to the outside of the high-permeability polyurethane film through medical acrylate adhesive; 2. Laying and hot pressing: Lay in the order from bottom to top: release protective film, high-permeability polyurethane film coated with medical acrylate adhesive, hydrophilic material core, and polyurethane backing film, use a hot press to compact the laid structure to ensure close contact between the structures, control the pressure at 10MPa, and hot press at a constant temperature of 120℃ for 40s, and then prepare the medical transparent dressing through cutting, wiring, and edge sealing.

[0024] Embodiment 2, an embodiment provided by the present invention: a medical transparent dressing and a manufacturing method thereof, the medical transparent dressing comprising a high-permeability polyurethane film 1, a hydrophilic material core 2, a polyurethane backing film 3, a medical acrylate adhesive layer 4 and a release protective film 5, wherein the polyurethane backing film 3 is arranged on the outside of the high-permeability polyurethane film 1, the hydrophilic material core 2 is arranged between the high-permeability polyurethane film 1 and the polyurethane backing film 3, the medical acrylate adhesive layer 4 is arranged on the other side of the high-permeability polyurethane film 1, and the release protective film 5 is arranged on the outside of the medical acrylate adhesive layer 4; The manufacturing method of the medical transparent dressing comprises the following steps: S1, raw material preparation; S2, viscose coating; S3, hot pressing and compounding; The steps of preparing raw materials are as follows: preparing high-permeability polyurethane film, hydrophilic material core, polyurethane backing film, medical acrylate adhesive and release film base material; The adhesive coating steps are as follows: use a roller coater to evenly coat a layer of medical acrylate adhesive on the surface of the high-permeability polyurethane film to ensure that the adhesive layer is uniform, smooth and of uniform thickness. The coating thickness of the medical acrylate adhesive is 8 μm; The hot pressing and compounding steps are as follows: 1. Adhesion preheating: adhere the release protective film to the outside of the high-permeability polyurethane film through medical acrylate adhesive, and place the film coated with the adhesive layer and the backing film in the hot air oven respectively to ensure that the surface of the film is flat, without wrinkles or bubbles, and keep an appropriate distance from the surface of the preheating equipment to avoid overheating caused by direct contact. Preheat at 60°C for 30 seconds. After the preheating is completed, take the film out of the preheating equipment and cool it naturally to room temperature; 2. Laying and hot pressing: Lay the release protective film, the high-permeability polyurethane film coated with medical acrylate adhesive, the hydrophilic material core, and the polyurethane backing film in this order from bottom to top. Use a hot press to compact the laid structure to ensure close contact between the structures. The pressure is controlled at 10MPa and hot pressed at a constant temperature of 120°C for 40 seconds. Then, the medical transparent dressing is prepared by cutting, wiring, and edge sealing.

[0025] Embodiment 3, an embodiment provided by the present invention: a medical transparent dressing and a manufacturing method thereof, the medical transparent dressing comprising a high-permeability polyurethane film 1, a hydrophilic material core 2, a polyurethane backing film 3, a medical acrylate adhesive layer 4 and a release protective film 5, wherein the polyurethane backing film 3 is arranged on the outside of the high-permeability polyurethane film 1, the hydrophilic material core 2 is arranged between the high-permeability polyurethane film 1 and the polyurethane backing film 3, the medical acrylate adhesive layer 4 is arranged on the other side of the high-permeability polyurethane film 1, and the release protective film 5 is arranged on the outside of the medical acrylate adhesive layer 4; The preparation method of the medical transparent dressing comprises the following steps: S1, raw material preparation; S2, adhesive coating; S3, laser drilling; S4, hot pressing compounding; The steps of preparing raw materials are as follows: preparing high-permeability polyurethane film, hydrophilic material core, polyurethane backing film, medical acrylate adhesive and release film base material; The adhesive coating steps are as follows: use a roller coater to evenly coat a layer of medical acrylate adhesive on the surface of the high-permeability polyurethane film to ensure that the adhesive layer is uniform, smooth and of uniform thickness. The coating thickness of the medical acrylate adhesive is 8 μm; The steps of laser drilling are as follows: 1. Material preparation: Place the high-permeability polyurethane film coated with medical acrylic adhesive on the workbench of the laser drilling machine to ensure that the surface is flat, clean and free of impurities; 2. Equipment debugging: Check whether the various functions of the laser drilling machine are normal, including the laser generator, focusing lens and control system, and adjust the working parameters of the laser drilling machine. The laser power is controlled at 5W, the pulse width is 0.2ms, the repetition frequency is controlled at 10KHz, and the scanning speed is controlled between 800mm / s; 3. Programming and drilling: According to the shape and distribution of the holes to be punched, write the control program of the laser drilling machine, start the laser drilling machine, and drill according to the preset program. During the drilling process, the drilling effect should be closely monitored, and the parameters should be adjusted in time to ensure the quality and consistency of the holes; 4. Post-punching processing: After the drilling is completed, the high-permeability polyurethane film coated with medical acrylic adhesive is cleaned, the residue is removed and dried to ensure the cleanliness and smoothness of the holes; The hot pressing and compounding steps are as follows: 1. Adhesion preheating: adhere the release protective film to the outside of the high-permeability polyurethane film through medical acrylate adhesive, and place the film coated with the adhesive layer and the backing film in the hot air oven respectively to ensure that the surface of the film is flat, without wrinkles or bubbles, and keep an appropriate distance from the surface of the preheating equipment to avoid overheating caused by direct contact. Preheat at 60°C for 30 seconds. After the preheating is completed, take the film out of the preheating equipment and cool it naturally to room temperature; 2. Laying and hot pressing: Lay the release protective film, the high-permeability polyurethane film coated with medical acrylate adhesive, the hydrophilic material core, and the polyurethane backing film in this order from bottom to top. Use a hot press to compact the laid structure to ensure close contact between the structures. The pressure is controlled at 10MPa and hot pressed at a constant temperature of 120°C for 40 seconds. Then, the medical transparent dressing is prepared by cutting, wiring, and edge sealing.

[0026] Embodiment 4, an embodiment provided by the present invention: a medical transparent dressing and a method for making the same, the medical transparent dressing comprising a high-permeability polyurethane film 1, a hydrophilic material core 2, a polyurethane backing film 3, a medical acrylate adhesive layer 4 and a release protective film 5, the polyurethane backing film 3 is arranged on the outside of the high-permeability polyurethane film 1, the hydrophilic material core 2 is arranged between the high-permeability polyurethane film 1 and the polyurethane backing film 3, the medical acrylate adhesive layer 4 is arranged on the other side of the high-permeability polyurethane film 1, and the release protective film 5 is arranged on the outside of the medical acrylate adhesive layer 4; The preparation method of the medical transparent dressing comprises the following steps: S1, raw material preparation; S2, adhesive coating; S3, laser drilling; S4, hot pressing compounding; S5, surface modification; The steps of preparing raw materials are as follows: preparing high-permeability polyurethane film, hydrophilic material core, polyurethane backing film, medical acrylate adhesive and release film base material; The adhesive coating steps are as follows: use a roller coater to evenly coat a layer of medical acrylate adhesive on the surface of the high-permeability polyurethane film to ensure that the adhesive layer is uniform, smooth and of uniform thickness. The coating thickness of the medical acrylate adhesive is 8 μm; The steps of laser drilling are as follows: 1. Material preparation: Place the high-permeability polyurethane film coated with medical acrylic adhesive on the workbench of the laser drilling machine to ensure that the surface is flat, clean and free of impurities; 2. Equipment debugging: Check whether the various functions of the laser drilling machine are normal, including the laser generator, focusing lens and control system, and adjust the working parameters of the laser drilling machine. The laser power is controlled at 5W, the pulse width is 0.2ms, the repetition frequency is controlled at 10KHz, and the scanning speed is controlled between 800mm / s; 3. Programming and drilling: According to the shape and distribution of the holes to be punched, write the control program of the laser drilling machine, start the laser drilling machine, and drill according to the preset program. During the drilling process, the drilling effect should be closely monitored, and the parameters should be adjusted in time to ensure the quality and consistency of the holes; 4. Post-punching processing: After the drilling is completed, the high-permeability polyurethane film coated with medical acrylic adhesive is cleaned, the residue is removed and dried to ensure the cleanliness and smoothness of the holes; The hot pressing compounding steps are as follows: 1. Adhesion preheating: adhere the release protective film to the outside of the high-permeability polyurethane film through medical acrylate adhesive, place the film coated with the adhesive layer and the backing film in the hot air oven respectively, ensure that the surface of the film is flat, without wrinkles or bubbles, and keep an appropriate distance from the surface of the preheating equipment to avoid overheating caused by direct contact, preheat at 60°C for 30s, and after the preheating is completed, take the film out of the preheating equipment and cool it naturally to room temperature; 2. Laying hot pressing: Lay in the order of release protective film, high-permeability polyurethane film coated with medical acrylate adhesive, hydrophilic material core, and polyurethane backing film from bottom to top, use a hot press to compact the laid structure to ensure close contact between the structures, control the pressure at 10MPa, and hot press at a constant temperature of 120°C for 40s, and then prepare the medical transparent dressing through cutting, wiring, and edge sealing; The surface modification steps are as follows: place the prepared medical transparent dressing in the treatment area of ​​the plasma treatment equipment, ensure that the surface of the dressing is flat and completely exposed to the plasma, use atmospheric pressure plasma jet equipment to perform plasma treatment on the medical transparent dressing. During the treatment process, the high-energy particles in the plasma will bombard the surface of the dressing to cause etching and activation changes on the surface. The surface of the medical transparent dressing has more -NH2 polar groups. The plasma reaction temperature is controlled at 120°C, and the plasma treatment time is 15s. Take out the dressing and perform post-processing after cleaning and drying.

[0027] Embodiment 5, an embodiment provided by the present invention: a medical transparent dressing and a manufacturing method thereof, the medical transparent dressing comprising a high-permeability polyurethane film 1, a hydrophilic material core 2, a polyurethane backing film 3, a medical acrylate adhesive layer 4 and a release protective film 5, wherein the polyurethane backing film 3 is arranged on the outside of the high-permeability polyurethane film 1, the hydrophilic material core 2 is arranged between the high-permeability polyurethane film 1 and the polyurethane backing film 3, the medical acrylate adhesive layer 4 is arranged on the other side of the high-permeability polyurethane film 1, and the release protective film 5 is arranged on the outside of the medical acrylate adhesive layer 4; The preparation method of the medical transparent dressing comprises the following steps: S1, raw material preparation; S2, adhesive coating; S3, laser drilling; S4, hot pressing compounding; S5, surface modification; The steps of preparing raw materials are as follows: preparing high-permeability polyurethane film, hydrophilic material core, polyurethane backing film, medical acrylate adhesive and release film base material; The adhesive coating steps are as follows: use a roller coater to evenly coat a layer of medical acrylate adhesive on the surface of the high-permeability polyurethane film to ensure that the adhesive layer is uniform, smooth and of uniform thickness. The coating thickness of the medical acrylate adhesive is 12 μm; The steps of laser drilling are as follows: 1. Material preparation: Place the high-permeability polyurethane film coated with medical acrylic adhesive on the workbench of the laser drilling machine to ensure that the surface is flat, clean and free of impurities; 2. Equipment debugging: Check whether the various functions of the laser drilling machine are normal, including the laser generator, focusing lens and control system, and adjust the working parameters of the laser drilling machine. The laser power is controlled at 5W, the pulse width is 0.2ms, the repetition frequency is controlled at 10KHz, and the scanning speed is controlled between 800mm / s; 3. Programming and drilling: According to the shape and distribution of the holes to be punched, write the control program of the laser drilling machine, start the laser drilling machine, and drill according to the preset program. During the drilling process, the drilling effect should be closely monitored, and the parameters should be adjusted in time to ensure the quality and consistency of the holes; 4. Post-punching processing: After the drilling is completed, the high-permeability polyurethane film coated with medical acrylic adhesive is cleaned, the residue is removed and dried to ensure the cleanliness and smoothness of the holes; The hot pressing compounding steps are as follows: 1. Adhesion preheating: adhere the release protective film to the outside of the high-permeability polyurethane film through medical acrylate adhesive, place the film coated with the adhesive layer and the backing film in the hot air oven respectively, ensure that the surface of the film is flat, without wrinkles or bubbles, and keep an appropriate distance from the surface of the preheating equipment to avoid overheating caused by direct contact, preheat at 60°C for 30s, and after the preheating is completed, take the film out of the preheating equipment and cool it naturally to room temperature; 2. Laying hot pressing: Lay the release protective film, the high-permeability polyurethane film coated with medical acrylate adhesive, the hydrophilic material core, and the polyurethane backing film in order from bottom to top, use a hot press to compact the laid structure to ensure close contact between the structures, control the pressure at 10MPa, and hot press at a constant temperature of 120°C for 40, and then prepare the medical transparent dressing through cutting, wiring, and edge sealing; The surface modification steps are as follows: place the prepared medical transparent dressing in the treatment area of ​​the plasma treatment equipment, ensure that the surface of the dressing is flat and completely exposed to the plasma, use atmospheric pressure plasma jet equipment to perform plasma treatment on the medical transparent dressing. During the treatment process, the high-energy particles in the plasma will bombard the surface of the dressing to cause etching and activation changes on the surface. The surface of the medical transparent dressing has more -NH2 polar groups. The plasma reaction temperature is controlled at 120°C, and the plasma treatment time is 15s. Take out the dressing and perform post-processing after cleaning and drying.

[0028] Embodiment 6, an embodiment provided by the present invention: a medical transparent dressing and a method for making the same, the medical transparent dressing comprising a high-permeability polyurethane film 1, a hydrophilic material core 2, a polyurethane backing film 3, a medical acrylate adhesive layer 4 and a release protective film 5, the polyurethane backing film 3 is arranged on the outside of the high-permeability polyurethane film 1, the hydrophilic material core 2 is arranged between the high-permeability polyurethane film 1 and the polyurethane backing film 3, the medical acrylate adhesive layer 4 is arranged on the other side of the high-permeability polyurethane film 1, and the release protective film 5 is arranged on the outside of the medical acrylate adhesive layer 4; The preparation method of the medical transparent dressing comprises the following steps: S1, raw material preparation; S2, adhesive coating; S3, laser drilling; S4, hot pressing compounding; S5, surface modification; The steps of preparing raw materials are as follows: preparing high-permeability polyurethane film, hydrophilic material core, polyurethane backing film, medical acrylate adhesive and release film base material; The adhesive coating steps are as follows: use a roller coater to evenly coat a layer of medical acrylate adhesive on the surface of the high-permeability polyurethane film to ensure that the adhesive layer is uniform, smooth and of uniform thickness. The coating thickness of the medical acrylate adhesive is 15 μm; The steps of laser drilling are as follows: 1. Material preparation: Place the high-permeability polyurethane film coated with medical acrylic adhesive on the workbench of the laser drilling machine to ensure that the surface is flat, clean and free of impurities; 2. Equipment debugging: Check whether the various functions of the laser drilling machine are normal, including the laser generator, focusing lens and control system, and adjust the working parameters of the laser drilling machine. The laser power is controlled at 5W, the pulse width is 0.2ms, the repetition frequency is controlled at 10KHz, and the scanning speed is controlled between 800mm / s; 3. Programming and drilling: According to the shape and distribution of the holes to be punched, write the control program of the laser drilling machine, start the laser drilling machine, and drill according to the preset program. During the drilling process, the drilling effect should be closely monitored, and the parameters should be adjusted in time to ensure the quality and consistency of the holes; 4. Post-punching processing: After the drilling is completed, the high-permeability polyurethane film coated with medical acrylic adhesive is cleaned, the residue is removed and dried to ensure the cleanliness and smoothness of the holes; The hot pressing compounding steps are as follows: 1. Adhesion preheating: adhere the release protective film to the outside of the high-permeability polyurethane film through medical acrylate adhesive, place the film coated with the adhesive layer and the backing film in the hot air oven respectively, ensure that the surface of the film is flat, without wrinkles or bubbles, and keep an appropriate distance from the surface of the preheating equipment to avoid overheating caused by direct contact, preheat at 60°C for 30s, and after the preheating is completed, take the film out of the preheating equipment and cool it naturally to room temperature; 2. Laying hot pressing: Lay the release protective film, the high-permeability polyurethane film coated with medical acrylate adhesive, the hydrophilic material core, and the polyurethane backing film in order from bottom to top, use a hot press to compact the laid structure to ensure close contact between the structures, control the pressure at 10MPa, and hot press at a constant temperature of 120°C for 40, and then prepare the medical transparent dressing through cutting, wiring, and edge sealing; The surface modification steps are as follows: place the prepared medical transparent dressing in the treatment area of ​​the plasma treatment equipment, ensure that the surface of the dressing is flat and completely exposed to the plasma, use atmospheric pressure plasma jet equipment to perform plasma treatment on the medical transparent dressing. During the treatment process, the high-energy particles in the plasma will bombard the surface of the dressing to cause etching and activation changes on the surface. The surface of the medical transparent dressing has more -NH2 polar groups. The plasma reaction temperature is controlled at 120°C, and the plasma treatment time is 15s. Take out the dressing and perform post-processing after cleaning and drying.

[0029] Performance Test: 1. Moisture permeability: Use WVTR-RC6 water vapor transmission rate tester to automatically test, simulate the temperature and humidity conditions of human skin, measure the amount of water vapor passing through the dressing per unit area in a certain period of time, and thus obtain the moisture permeability result; 2. Biocompatibility: (1) Sensitization test: The dressing is placed in contact with human skin or mucous membranes to observe whether the human body develops allergic symptoms, thereby evaluating the sensitization of the dressing; (2) Blood compatibility test: The dressing is evaluated for its ability to not cause obvious blood reactions after interacting with blood. The dressing is placed in contact with a simulated blood environment to observe indicators such as blood flow status, platelet adhesion and aggregation, thereby evaluating the blood compatibility of the dressing; 3. Adhesion strength: Use a fiber bonding strength tester to measure the positive tensile bonding strength and tensile strength parameters between the high-permeability polyurethane film and the polyurethane backing film. Apply a certain tensile force to the sample to observe the behavior of the sample during the stretching process to evaluate the adhesion strength between the high-permeability polyurethane film and the polyurethane backing film.

[0030] The test data of each embodiment under the same test conditions are shown in Table 1

[0031] Table 1 It can be seen from the experimental data in Table 1 that when the coating thickness of the medical acrylate adhesive is 15 μm, the medical transparent dressing made by punching holes in the medical acrylate adhesive with a laser puncher has more water vapor transmission paths, the moisture permeability of the dressing is significantly improved, and the skin around the wound can breathe and moisturize better, which is beneficial to maintain the original performance and integrity of the medical acrylate adhesive layer and reduce the discomfort of patients using the dressing. Preheating the high permeability polyurethane film and the polyurethane backing film before hot pressing composite improves the flexibility and adhesion of the material, and the composite effect is better. After modifying the dressing surface by plasma treatment, the surface roughness and specific surface area are increased, which is beneficial to the penetration of water vapor, further improving the moisture permeability of the dressing, and improving the biocompatibility to make it more hydrophilic, thereby reducing irritation and rejection reactions to the skin and promoting cell growth and repair.

[0032] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

Claims

1. A method for making a medical transparent dressing, characterized in that: The method comprises the following steps: S1, raw material preparation; S2, adhesive coating; S3, laser drilling; S4, hot pressing and laminating; S5, surface modification; The laser drilling steps are as follows:

1. material preparation; 2. equipment debugging; 3. programming and drilling; 4. post-drilling processing.

2. The method for making a medical transparent dressing according to claim 1, characterized in that: The raw material preparation steps are as follows: prepare a high-permeability polyurethane film, a hydrophilic material core, a polyurethane backing film, a medical acrylate adhesive and a release protective film base material.

3. The method for making a medical transparent dressing according to claim 1, characterized in that: The adhesive coating step is as follows: a layer of medical acrylic adhesive is evenly coated on the surface of the high-permeability polyurethane film using a roller coater to ensure that the adhesive layer is even, smooth and of uniform thickness.

4. The method for making a medical transparent dressing according to claim 3, characterized in that: The coating thickness of the medical acrylic adhesive is 8 to 15 μm.

5. The method for making a medical transparent dressing according to claim 1, characterized in that: The laser drilling steps are as follows: Step (1) Material preparation: Place the high-permeability polyurethane film coated with medical acrylic adhesive on the workbench of the laser drilling machine to ensure that the surface is flat, clean and free of impurities; Step (2) Equipment debugging: Check whether the various functions of the laser drilling machine are normal, including the laser generator, focusing lens and control system, and adjust the working parameters of the laser drilling machine. The laser power is controlled at 5 to 10 W, the pulse width is 0.2 to 1.0 ms, the repetition frequency is controlled at 10 to 100 kHz, and the scanning speed is controlled between 800 and 1200 mm / s; Step (3) Programming and drilling: According to the shape and distribution of the holes to be punched, write the control program of the laser drilling machine, start the laser drilling machine, and drill according to the preset program. During the drilling process, the drilling effect should be closely monitored, and the parameters should be adjusted in time to ensure the quality and consistency of the holes; Step (4) Post-punching processing: After the drilling is completed, the high-permeability polyurethane film coated with medical acrylic adhesive is cleaned, the residue is removed and dried to ensure the cleanliness and smoothness of the holes.

6. The method for making a medical transparent dressing according to claim 1, characterized in that: The hot pressing and laminating steps are as follows: Step (1) adhesion preheating: adhere the release protective film to the outer side of the high-permeability polyurethane film through medical acrylate adhesive, place the film coated with the adhesive layer and the backing film in a hot air oven respectively, ensure that the surface of the film is flat, without wrinkles or bubbles, and keep an appropriate distance from the surface of the preheating equipment to avoid overheating caused by direct contact, preheat at 60-80°C for 30-50s, and after preheating, take the film out of the preheating equipment and cool it naturally to room temperature; Step (2) laying and hot pressing: lay the release protective film, the high-permeability polyurethane film coated with medical acrylate adhesive, the hydrophilic material core, and the polyurethane backing film in order from bottom to top, use a hot press to compact the laid structure to ensure close contact between the structures, control the pressure at 10MPa-20MPa, and hot press at a constant temperature of 120°C for 40-50s, and then prepare the medical transparent dressing through cutting, wiring, and edge sealing.

7. The method for making a medical transparent dressing according to claim 1, characterized in that: The surface modification steps are as follows: placing the prepared medical transparent dressing in the treatment area of ​​the plasma treatment equipment, ensuring that the surface of the dressing is flat and completely exposed to the plasma, using an atmospheric pressure plasma jet device to perform plasma treatment on the medical transparent dressing. During the treatment process, the high-energy particles in the plasma will bombard the surface of the dressing to cause etching and activation changes on the surface. The surface of the medical transparent dressing has more -NH2 polar groups. The plasma reaction temperature is controlled at 120°C to 180°C, the plasma treatment time is 15s to 20s, and the dressing is taken out and cleaned and dried for post-treatment.

8. The transparent medical dressing prepared by the method for preparing a transparent medical dressing according to any one of claims 1 to 7, characterized in that: The medical transparent dressing comprises a high-permeability polyurethane film (1), a hydrophilic material core (2), a polyurethane backing film (3), a medical acrylate adhesive layer (4) and a release protective film (5), wherein the polyurethane backing film (3) is arranged on the outside of the high-permeability polyurethane film (1), the hydrophilic material core (2) is arranged between the high-permeability polyurethane film (1) and the polyurethane backing film (3), the medical acrylate adhesive layer (4) is arranged on the other side of the high-permeability polyurethane film (1), and the release protective film (5) is arranged on the outside of the medical acrylate adhesive layer (4).

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