Portable blood routine examination device and examination method

Abstract

The invention relates to the technical field of medical instruments, and discloses a portable blood routine examination device and method, the portable blood routine examination device comprises a box body, one side of the box body is provided with a slide inlet for inserting a slide, and the other side of the box body is provided with a slide recovery port for recovering the slide; the slideway is arranged in the box body, a sliding frame is in sliding fit with the slideway, and supporting plates are arranged on the two opposite side walls of the sliding frame through telescopic mechanisms correspondingly; the three-axis platform is arranged in the box body, an installation block is arranged on the three-axis platform in a transmission fit mode, the installation block is located above the sliding frame, and a scanning module used for scanning the slide is arranged on the installation block; the blood routine examination box is small in overall size, light in weight, convenient to carry and move, free of complex sample treatment or professional skills, easy to operate, capable of enabling medical staff to conduct blood routine examination at different places at any time, convenient to use and high in efficiency. The system is suitable for emergency treatment, field rescue, remote areas or mobile medical vehicles.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a portable blood routine testing device and testing method. Background Art

[0002] Routine blood tests can help identify blood diseases such as anemia, leukemia, and thrombocytopenia. White blood cell counts can be used to observe responses to infection or inflammation, and platelet counts can help assess hemostasis. Red blood cell counts and hemoglobin concentrations can be used to assess anemia, and white blood cell counts can reflect the body's immune status.

[0003] However, although there are automated instruments for routine blood tests at present, they are large in size. Large routine blood test equipment usually takes up a large space and requires special laboratories or medical institutions to install and use. In addition, medical personnel must undergo special training to correctly operate the equipment and interpret the results. Otherwise, misdiagnosis or incorrect interpretation of the results may occur, which makes it difficult to use in mobile medical or emergency situations. In emergency situations, remote areas or with limited resources, these devices may not be used in time for routine blood tests. Summary of the invention

[0004] The object of the present invention is to provide a portable blood routine test device and test method, aiming to solve or improve at least one of the above-mentioned technical problems.

[0005] To achieve the above object, the present invention provides the following solution: The present invention provides a portable blood routine test device, comprising:

[0006] A box body, wherein one side of the box body is provided with a slide entrance for inserting a slide, and the other side of the box body is provided with a slide recovery port for recovering the slide;

[0007] A slide, the slide is arranged inside the box, the two ends of the slide are respectively connected to the glass slide inlet and the glass slide recovery port, a sliding frame is slidably matched on the slide, and the two opposite side walls of the sliding frame are respectively provided with supporting plates through a telescopic mechanism, and the two supporting plates are used to support the two ends of the glass slide;

[0008] A three-axis platform, the three-axis platform is arranged in the box, a mounting block is provided on the three-axis platform for transmission, the mounting block is located above the sliding frame, and a scanning module for scanning the glass slide is provided on the mounting block;

[0009] An analysis system is arranged on the box body and connected to the scanning module.

[0010] Optionally, the slideway is composed of a pair of side panels, and electric slide rails are arranged on the side panels, and both ends of the sliding frame are respectively connected to the electric sliding blocks on the two electric slide rails.

[0011] Optionally, the telescopic mechanism includes a through slot, which is opened on the side wall of the sliding frame, a pair of telescopic rods are rotatably connected in the through slot via a rotating shaft, a spring is fixedly connected between the pair of telescopic rods, one end of the pair of telescopic rods close to the support plate slides with the support plate, one end of the pair of telescopic rods away from the support plate is hinged to each other via a hinge seat, a push block is fixedly connected to the hinge seat, and a contact block is fixedly connected to one end of the side panel close to the glass slide recovery port, the contact block corresponds to the push block, and the push block and the contact block are butted against each other via an arc surface.

[0012] Optionally, a dovetail slide groove is provided on the support plate, two dovetail sliders are slidably connected in the dovetail slide groove, and the two dovetail sliders are hinged to the two telescopic rods one by one.

[0013] Optionally, the sliding frame is in a U-shape, and an opening of the sliding frame faces the slide entrance.

[0014] Optionally, an operation display screen, a switch button and an execution button electrically connected to the operation display screen are provided on the outer surface of the box body, and the analysis system is provided inside the operation display screen.

[0015] Optionally, the scanning module includes an area array camera, a line array camera and a microscope magnification lens.

[0016] Optionally, the slide recovery port is connected with a collection frame.

[0017] Optionally, the analysis system includes a target recognition module and a convolutional neural network classification model.

[0018] A blood routine examination method comprises the following steps:

[0019] Sampling blood, dropping a drop of blood into the slide, and dropping a drop of stain;

[0020] Pushing the glass slide with blood into the two support plates in the box through the glass slide entrance;

[0021] The slide is driven by the slide frame to slide along the slideway to the bottom of the scanning module, the scanning module performs blood scanning, and transmits the blood data to the analysis system, and the analysis system calculates to obtain the proportion of various types of cells in the blood;

[0022] The slide is driven by the slide frame to slide along the slide to above the slide recovery port, and the two telescopic mechanisms respectively control the two support plates to move away from each other, so that the slide falls to the slide recovery port.

[0023] The present invention discloses the following technical effects: a glass slide with a blood sample is inserted into a glass slide inlet so that the glass slide is placed on two support plates, a sliding frame slides along a slide, and a three-axis platform drives a mounting block to adjust the position of a scanning module so that the glass slide corresponds to the scanning module, and the scanning module cooperates with an analysis system to obtain the proportion of various types of cells in the blood. The overall volume is small, the weight is light, and the device is easy to carry and move. It does not require complicated sample processing or professional skills, and the operation is simple, so that medical personnel can perform routine blood tests at any time in different locations. The device is suitable for first aid, field rescue, remote areas, or mobile medical vehicle applications. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The drawings constituting a part of the present application are used to provide a further understanding of the present application. The illustrative embodiments and descriptions of the present application are used to explain the present application and do not constitute an improper limitation on the present application. In the drawings:

[0025] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0026] Figure 2 for Figure 1 Schematic diagram from another perspective;

[0027] Figure 3 It is a schematic diagram of the internal structure of the box of the present invention;

[0028] Figure 4 Figure 3 A partial enlarged view of middle A;

[0029] Figure 5 Figure 3 A partial enlarged view of B in the middle;

[0030] Figure 6 It is a structural schematic diagram of the telescopic mechanism of the present invention.

[0031] In the figure: 1. Box body; 2. Glass slide entrance; 3. Glass slide recovery port; 4. Slide; 5. Sliding rack; 6. Support plate; 7. Three-axis platform; 8. Mounting block; 9. Side panel; 10. Electric slide rail; 12. Through slot; 13. Rotating shaft; 14. Telescopic rod; 15. Articulated seat; 16. Push block; 17. Contact block; 18. Dovetail slide groove; 19. Dovetail slider; 20. Operation display screen; 21. Switch button; 22. Execution button; 23. Area array camera; 24. Line array camera; 25. Collection frame; 26. Spring; 27. Microscope magnifying lens. DETAILED DESCRIPTION

[0032] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0033] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0034] Reference Figure 1-Figure 6 The present invention provides a portable blood routine test device, comprising:

[0035] A box body 1, one side of the box body 1 is provided with a glass slide inlet 2 for inserting a glass slide, and the other side of the box body 1 is provided with a glass slide recovery port 3 for recovering the glass slide;

[0036] The slide 4 is arranged inside the box 1, and the two ends of the slide 4 are respectively connected with the glass slide inlet 2 and the glass slide recovery port 3. The slide 4 is slidably matched with a sliding frame 5. The two opposite side walls of the sliding frame 5 are respectively provided with supporting plates 6 through a telescopic mechanism. The two supporting plates 6 are used to support the two ends of the glass slide;

[0037] A three-axis platform 7, which is arranged in the box 1, and a mounting block 8 is provided on the three-axis platform 7 for transmission cooperation, and the mounting block 8 is located above the sliding frame 5, and a scanning module for scanning a glass slide is provided on the mounting block 8;

[0038] Analysis system: The analysis system is arranged on the box 1 and is connected to the scanning module.

[0039] A glass slide with a blood sample is inserted into the glass slide inlet 2, so that the glass slide is placed on two support plates 6, and the sliding frame 5 slides along the slide 4, and the three-axis platform 7 drives the mounting block 8 to adjust the position of the scanning module, so that the glass slide corresponds to the scanning module, and the scanning module cooperates with the analysis system to obtain the proportion of various types of cells in the blood. The overall volume is small, the weight is light, and it is easy to carry and move. It does not require complicated sample processing or professional skills, and the operation is simple, so that medical personnel can perform routine blood tests at different locations at any time. It is suitable for first aid, field rescue, remote areas or mobile medical vehicle applications.

[0040] Furthermore, a power supply and a circuit integrated board are arranged in the box 1 (this is the prior art and will not be described in detail here).

[0041] According to a further optimized solution, the slideway 4 is composed of a pair of side panels 9 , on which electric slide rails 10 are arranged, and both ends of the slide frame 5 are respectively connected to the electric slide blocks on the two electric slide rails 10 .

[0042] The electric slide block is driven by the electric slide rail 10 so that the sliding frame 5 slides along the slideway 4 .

[0043] Further optimized solution, the telescopic mechanism includes a through slot 12, the through slot 12 is provided on the side wall of the sliding frame 5, a pair of telescopic rods 14 are rotatably connected in the through slot 12 through a rotating shaft 13, a spring 26 is fixedly connected between the pair of telescopic rods 14, one end of the pair of telescopic rods 14 close to the support plate 6 is slidably matched with the support plate 6, and one end of the pair of telescopic rods 14 away from the support plate 6 is hinged to each other through a hinge seat 15, a push block 16 is fixedly connected to the hinge seat 15, and a contact block 17 is fixedly connected to the end of the side plate 9 close to the glass slide recovery port 3, the contact block 17 corresponds to the push block 16, and the push block 16 and the contact block 17 are abutted against each other through an arc surface. A dovetail slide 18 is provided on the support plate 6, and two dovetail sliders 19 are slidably connected in the dovetail slide 18, and the two dovetail sliders 19 are hinged to the two telescopic rods 14 one by one.

[0044] When the sliding frame 5 is close to the glass slide entrance 2, the contact block 17 and the push block 16 are misaligned. Due to the pulling force of the spring 26, the support plate 6 is located in the hollow area of ​​the sliding frame 5, so that the support plate 6 can support the glass slide when the glass slide is inserted. When the sliding frame 5 is above the glass slide recovery port 3, the contact block 17 and the push block 16 are butted against each other through the arc surface, so that the push block 16 drives the hinge seat 15 to move, so that the hinged ends of the two telescopic rods 14 translate, so that the telescopic rod 14 is telescoped and rotated along the rotating shaft 13 at the same time, so that the end of the telescopic rod 14 that is slidably connected to the support plate 6 rotates around the rotating shaft 13 as the axis, and at the same time, the telescopic rod 14 drives the dovetail slider 19 to slide along the dovetail slide groove 18, thereby pulling the support plate 6 away from the glass slide, so that the support plate 6 is retracted into the through groove 12, so that the glass slide falls automatically.

[0045] According to a further optimized solution, the sliding rack 5 is in a U-shape, and the opening of the sliding rack 5 faces the slide entrance 2 .

[0046] According to a further optimized solution, an operation display screen 20 , a switch button 21 and an execution button 22 electrically connected to the operation display screen 20 are provided on the outer surface of the housing 1 , and an analysis system is provided in the operation display screen 20 .

[0047] According to a further optimized solution, the scanning module includes an area array camera 23 , a line array camera 24 and a microscope magnifying lens 27 .

[0048] According to a further optimized solution, the slide recovery port 3 is connected with a collection frame 25 for collecting dropped slides.

[0049] To further optimize the solution, the analysis system includes a target recognition module and a convolutional neural network classification model.

[0050] A blood routine examination method comprises the following steps:

[0051] Early intelligent focusing of the scanning module: In the early stage, the area array camera 23 is used to manually collect images of the glass slide, in which both blurred and clear images are collected at the same time, and the reference height value corresponding to each image is recorded according to the z-axis of the three-axis platform 7, and then input into the deep learning model for training, and the model with the highest training accuracy is selected for saving, packaging and embedding in the analysis system. The z-axis default return position of the three-axis platform 7 is set to 0. The area array camera 23 and the line array camera 24 of the present invention are 8k cameras.

[0052] Blood is sampled from the finger using a commercially available finger card, a drop of blood is dripped onto a glass slide, a drop of dye is added, and finally a transparent glass slide is covered;

[0053] Push the slide with blood into the two support plates 6 in the box 1 through the slide inlet 2;

[0054] The slide is driven by the slide frame 5 to slide along the slide 4 to the bottom of the scanning module, and the line array camera 24 in the scanning module performs blood scanning. The target area of ​​the slide is set to 1cm*1cm, and the size of the synthetic image scanned by the line array camera 24 is designed to be 1mm*1mm, and then 1mm*1mm is cut into 1μm*1μm, and the blood data is transmitted to the analysis system (the 1μm*1μm unit image is sent to the target recognition module for target recognition and counting), and the analysis system calculates to obtain the proportion of each type of cell in the blood. The image after single cell cutting by the target recognition module is sent to the designed lightweight convolutional neural network classification model, and then monocytes, lymphocytes, eosinophils, basophils, neutrophil segmented granulocytes, neutrophil rod granulocytes in white blood cells, hemoglobin, reticulocytes, megaloblasts and platelets in red blood cells are identified, and the proportion of each type of cell is calculated, and finally a report is output to the operation display screen 20 for printing);

[0055] The slide is driven by the slide frame 5 to slide along the slide 4 to above the slide recovery port 3 , and the two telescopic mechanisms respectively control the two support plates 6 to move away from each other, so that the slide falls to the slide recovery port 3 .

[0056] Furthermore, the target recognition module is a YOLOV8 model, and the model training parameters are set as follows: learning rate 0.001, momentum 0.9, weight decay 0.001, non-maximum suppression threshold 0.5, confidence threshold 0.5, and loss function includes coordinate loss and confidence loss.

[0057] Furthermore, the convolutional neural network classification model is MobileNet, and the model training parameters are set as follows: learning rate 0.001, optimizer is stochastic gradient descent, momentum is set to 0.9, weight decay is set to 0.001, and dropout rate is set to 0.5.

[0058] In the description of the present invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0059] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A portable blood routine test device, characterized in that: include: A box body (1), wherein one side of the box body (1) is provided with a glass slide entrance (2) for inserting a glass slide, and the other side of the box body (1) is provided with a glass slide recovery port (3) for recovering the glass slide; A slideway (4), the slideway (4) being arranged inside the box (1), the two ends of the slideway (4) being respectively connected to the glass slide inlet (2) and the glass slide recovery port (3), the slideway (4) being slidably matched with a sliding frame (5), the two opposite side walls of the sliding frame (5) being respectively provided with supporting plates (6) through a telescopic mechanism, the two supporting plates (6) being used to support the two ends of the glass slide; A three-axis platform (7), the three-axis platform (7) being arranged in the box body (1), the three-axis platform (7) being transmission-coordinated with a mounting block (8), the mounting block (8) being located above the sliding frame (5), and the mounting block (8) being provided with a scanning module for scanning the glass slide; An analysis system, wherein the analysis system is arranged on the box (1) and is connected to the scanning module.

2. The portable blood routine test device according to claim 1, characterized in that: The slideway (4) is composed of a pair of side plates (9), on which electric slide rails (10) are arranged, and the two ends of the sliding frame (5) are respectively connected to the electric slide blocks on the two electric slide rails (10).

3. The portable blood routine test device according to claim 2, characterized in that: The telescopic mechanism comprises a through slot (12), wherein the through slot (12) is arranged on a side wall of the sliding frame (5), a pair of telescopic rods (14) are rotatably connected in the through slot (12) via a rotating shaft (13), a spring (26) is fixedly connected between the pair of telescopic rods (14), one end of the pair of telescopic rods (14) close to the support plate (6) is slidably matched with the support plate (6), and one end of the pair of telescopic rods (14) away from the support plate (6) is hinged to each other via a hinge seat (15), a push block (16) is fixedly connected to the hinge seat (15), and a contact block (17) is fixedly connected to one end of the side plate (9) close to the glass slide recovery port (3), the contact block (17) corresponds to the push block (16), and the push block (16) and the contact block (17) are butted against each other via an arc surface.

4. The portable blood routine test device according to claim 3, characterized in that: The support plate (6) is provided with a dovetail slide groove (18), and two dovetail sliders (19) are slidably connected in the dovetail slide groove (18), and the two dovetail sliders (19) are hinged to the two telescopic rods (14) one by one.

5. The portable blood routine test device according to claim 1, characterized in that: The sliding frame (5) is in the shape of a U, and the opening of the sliding frame (5) faces the glass slide entrance (2).

6. The portable blood routine test device according to claim 1, characterized in that: An operation display screen (20), a switch button (21) and an execution button (22) electrically connected to the operation display screen (20) are arranged on the outer surface of the box body (1), and the analysis system is arranged inside the operation display screen (20).

7. The portable blood routine test device according to claim 1, characterized in that: The scanning module comprises an area array camera (23), a line array camera (24) and a microscope magnifying lens (27).

8. The portable blood routine test device according to claim 1, characterized in that: The slide recovery port (3) is plugged with a collection frame (25).

9. The portable blood routine test device according to claim 1, characterized in that: The analysis system includes a target recognition module and a convolutional neural network classification model.

10. A blood routine test method, based on the portable blood routine test device according to any one of claims 1 to 9, characterized in that: The following steps are involved: Sampling blood, dropping a drop of blood into the slide, and dropping a drop of stain; Pushing the glass slide with blood from the glass slide inlet (2) onto the two support plates (6) in the box (1); The slide is driven by the slide frame (5) to slide along the slideway (4) to the bottom of the scanning module, the scanning module performs blood scanning, and transmits the blood data to the analysis system, and the analysis system calculates to obtain the proportion of various types of cells in the blood; The slide is driven by the slide frame (5) to slide along the slideway (4) to above the slide recovery port (3), and the two telescopic mechanisms respectively control the two support plates (6) to move away from each other, so that the slide falls to the slide recovery port (3).

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