Modeling device for asthenospermia rat model

Abstract

The invention discloses an asthenospermia rat model modeling device, and relates to the technical field of animal model modeling, the device comprises a box body and a box cover, a transparent irradiation plate is arranged in the box body, an electric heating rod and a temperature acquisition sensor are fixed on the top of a modeling movable cavity, an RF emitter is fixed on the side wall of the modeling movable cavity, and the RF emitter is fixed on the box cover. A collimating lens, a beam splitter and an X-ray tube are fixed in the radiation working cavity, and the electrical bar, the temperature acquisition sensor, the RF transmitter, the X-ray tube and the radiation field adjusting mechanism are all connected with the control circuit board. The device integrates various asthenospermia inducing factors including temperature, electromagnetic radiation and nuclear radiation, one or more inducing factors can be utilized to establish an asthenospermia rat model, and the inducing mechanism of asthenospermia can be researched in the modeling process.

Description

Technical Field

[0001] The invention relates to the technical field of medical tools, and in particular to a device for making a model of asthenozoospermia rats. Background Art

[0002] Asthenozoospermia refers to a condition in which the forward-moving sperm (grades a and b) in semen parameters are less than 50% or the grade a-moving sperm are less than 25%. Asthenozoospermia is also known as low sperm motility. The motility or movement ability of sperm is directly related to human reproduction. Only sperm that move forward normally can ensure that the sperm reaches the ampulla of the fallopian tube and combines with the egg to form a fertilized egg. Normal sperm should be able to have sufficient motility to swim in the female reproductive tract to reach the egg and complete the fertilization process. If the sperm has insufficient motility, it is considered a manifestation of asthenozoospermia. Asthenozoospermia can be divided into two types, including abnormal motility and motility variant.

[0003] Factors that cause asthenozoospermia include testicular spermatogenesis disorder, vas deferens obstruction, long-term drinking and smoking, high temperature environment, exposure to harmful substances, lack of trace elements, insufficient testosterone secretion, cryptorchidism, long-term exposure to radiation environment or long-term exposure to nuclear radiation environment. The induction mechanism of asthenozoospermia and the development of corresponding therapeutic drugs based on it are the hot spots of current medical research, and the smooth development of research requires the help of corresponding animal models. Therefore, the establishment of asthenozoospermia rat model is the first step in clinical research.

[0004] At present, the establishment of asthenozoospermia rat models mainly relies on artificial injection of corresponding biological or chemical agents and corresponding surgical intervention. The injection of biological or chemical agents can cause reproductive system infection and endocrine hormone disorders in rats, thereby quickly establishing an asthenozoospermia rat model. However, factors that cause asthenozoospermia in real life include smoking, electromagnetic radiation, and nuclear radiation. Whether the mechanism by which these factors induce asthenozoospermia is the same as the mechanism by which asthenozoospermia is induced by the injection of biological or chemical agents is still unclear. Therefore, it is not rigorous to conduct clinical research using only biological or chemical agents to establish asthenozoospermia rats. Summary of the invention

[0005] In order to solve the above technical problems, the present invention provides a modeling device for asthenozoospermia rats, which integrates a variety of asthenozoospermia inducing factors, including temperature, electromagnetic radiation and nuclear radiation. One or more inducing factors can be used to establish an asthenozoospermia rat model, and the inducing mechanism of asthenozoospermia can be studied during the modeling process. Since the damage caused by the above-mentioned asthenozoospermia modeling is reversible, drug research and drug evaluation can be carried out on the rat model after successful modeling; the device innovatively uses nuclear radiation to perform asthenozoospermia modeling on rats, and the radiation area of ​​the nuclear radiation can be adjusted according to actual needs, and the adjustment operation is convenient.

[0006] In order to achieve the above technical effects, the present invention is implemented by the following technical solutions: The asthenozoospermia rat model making device comprises a box body and a box cover, wherein the box cover is hinged to the front of the box body, a control panel is fixed to the front of the box body, a display screen and operation buttons are fixed to the control panel, a transparent irradiation plate is arranged in the box body, the irradiation plate divides the box body into an upper modeling activity chamber and a lower radiation working chamber, a partition plate is fixed to the right side of the irradiation plate, the chamber to the right side of the partition plate is an equipment chamber, a control circuit board and a battery are fixed in the equipment chamber, the battery is connected to the control circuit board, an electric heating rod and a temperature control device are fixed to the top of the modeling activity chamber, and a temperature control device is provided to control the modeling activity chamber. The temperature collection sensor, the RF transmitter is fixed on the side wall of the modeling activity cavity, the radiation working cavity is fixed with a collimating lens, a beam splitter and an X-ray tube, the X-ray tube is fixed to the bottom of the radiation working cavity, the beam splitter is fixed on the irradiation field adjustment mechanism, the electric heating rod, the temperature collection sensor, the RF transmitter, the X-ray tube and the irradiation field adjustment mechanism are all connected to the control circuit board, the collimating lens is fixed to the bottom of the irradiation plate, and the irradiation field adjustment mechanism can adjust the distance between the beam splitter and the collimating lens to adjust the size of the X-ray radiation area.

[0007] Furthermore, the irradiation field adjustment mechanism includes a pair of stepper motors, a pair of lead screws and a supporting plate, the lead screws are fixed on the rotating shaft of the stepper motor, the lead screws are arranged on both sides of the supporting plate, the lead screws pass through the supporting plate and are threadedly connected to the supporting plate, and the collimating lens is fixed at the center of the supporting plate.

[0008] Furthermore, the collimating lens is a single convex mirror.

[0009] Furthermore, the box body and the box cover are both composed of an inner radiation isolation layer, a middle thermal insulation layer and an outer structural layer.

[0010] Furthermore, the radiation isolation layer is made of lead plate, the thermal insulation layer is made of XPS plate, and the structural layer is made of stainless steel plate.

[0011] Furthermore, a processing chip, a power module, a boost module, a digital-to-analog conversion module, a relay module, an analog-to-digital conversion module, a constant current source drive module and an RF signal generator are fixed on the control circuit board; the power module, the boost module, the digital-to-analog conversion module, the analog-to-digital conversion module, the constant current source drive module and the RF signal generator are all connected to the processing chip, the relay module is connected to the digital-to-analog conversion module, the stepper motor is connected to the relay module, the X-ray tube is connected to the boost module, the battery is connected to the power module, and the RF transmitter is connected to the RF signal generator.

[0012] Furthermore, the RF radio frequency signal generator uses a crystal oscillator.

[0013] The beneficial effects of the present invention are as follows: the device combines a variety of asthenozoospermia inducing factors, including temperature, electromagnetic radiation and nuclear radiation. One or more inducing factors can be used to establish an asthenozoospermia rat model. The inducing mechanism of asthenozoospermia can be studied during the modeling process. Since the damage caused by the above-mentioned asthenozoospermia modeling is reversible, drug research and drug evaluation can be carried out on the rat model after the modeling is successful. The device innovatively uses nuclear radiation to perform asthenozoospermia modeling on rats, and the radiation area of ​​the nuclear radiation can be adjusted according to actual needs, and the adjustment operation is convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for describing the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0015] Figure 1 It is a schematic diagram of the overall structure of the asthenozoospermia rat model making device; Figure 2 This is a schematic diagram of the internal structure of the asthenozoospermia rat model making device; Figure 3 is a schematic diagram of the cross-sectional structure of the box; Figure 4 is a schematic diagram of the composition structure of the irradiation field adjustment mechanism; Figure 5 It is a schematic diagram of the structural layout of the control circuit board.

[0016] In the accompanying drawings, the components represented by the reference numerals are listed as follows: 1-box body, 2-box cover, 3-control panel, 4-display screen, 5-operation button, 6-irradiation plate, 7-molding activity cavity, 8-radiation working cavity, 9-carrying plate, 10-X-ray tube, 11-beam splitter, 12-collimating lens, 13-electric heating rod, 14-temperature acquisition sensor, 15-RF radio frequency transmitter, 16-partition plate, 17-equipment cavity, 18-control circuit board, 19-battery, 20-stepping motor, 21-screw, 101-structural layer, 102-insulation layer, 103-radiation isolation layer, 181-processing chip, 182-power module, 183-boost module, 184-digital-to-analog conversion module, 185-relay module, 186-analog-to-digital conversion module, 187-constant current source drive module, 188-RF radio frequency signal generator. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] like Figure 1-3 As shown, the asthenozoospermia rat model modeling device comprises a box body 1 and a box cover 2, the box cover is hinged to the front of the box body, a control panel 3 is also fixed to the front of the box body 1, a display screen 4 and an operation button 5 are fixed to the control panel 3, a transparent irradiation plate 6 is arranged in the box body 1, the irradiation plate 6 divides the box body into an upper modeling activity chamber 7 and a lower radiation working chamber 8, a partition plate 16 is fixed to the right side of the irradiation plate 6, the chamber on the right side of the partition plate 16 is an equipment chamber 17, a control circuit board 18 and a battery 19 are fixed in the equipment chamber 17, the battery 19 is connected to the control circuit board 18, an electric heating rod 13 and a temperature control rod 14 are fixed to the top of the modeling activity chamber 7, and a heating rod 14 and a temperature control rod 15 are fixed to the top of the modeling activity chamber 7. A temperature collection sensor 14 is provided, and an RF radio frequency transmitter 15 is fixed to the side wall of the modeling activity cavity. A collimating lens 12, a beam splitter 11 and an X-ray tube 10 are fixed in the radiation working cavity 8. The X-ray tube 10 is fixed to the bottom of the radiation working cavity 8, and the beam splitter 11 is fixed to the irradiation field adjustment mechanism. The electric heating rod 13, the temperature collection sensor 14, the RF radio frequency transmitter 15, the X-ray tube 10 and the irradiation field adjustment mechanism are all connected to the control circuit board 18. The collimating lens 12 is fixed to the bottom of the irradiation plate 6, and the irradiation field adjustment mechanism can adjust the distance between the beam splitter 11 and the collimating lens 12 to adjust the size of the X-ray radiation area.

[0019] like Figure 4 As shown, the irradiation field adjustment mechanism includes a pair of stepper motors 20, a pair of lead screws 21 and a supporting plate 9. The lead screws 21 are fixed on the rotating shaft of the stepper motor 20. The lead screws 21 are arranged on both sides of the supporting plate 9. The lead screws 21 pass through the supporting plate 9 and are threadedly connected to the supporting plate 9. The collimating lens 11 is fixed at the center of the supporting plate 9.

[0020] In this embodiment, the collimating lens 12 is a single convex mirror.

[0021] In this embodiment, the box body 1 and the box cover 2 are both composed of an inner radiation isolation layer 103 , a middle thermal insulation layer 102 , and an outer structural layer 101 .

[0022] In this embodiment, the radiation isolation layer is made of lead plate, the thermal insulation layer is made of XPS plate, and the structural layer is made of stainless steel plate.

[0023] like Figure 5As shown, a processing chip 181, a power module 182, a boost module 183, a digital-to-analog conversion module 184, a relay module 185, an analog-to-digital conversion module 186, a constant current source drive module 187 and an RF signal generator 188 are fixed on the control circuit board 18. The power module 182, the boost module 183, the digital-to-analog conversion module 184, the analog-to-digital conversion module 186, the constant current source drive module 187 and the RF signal generator 188 are all connected to the processing chip 181, the relay module 185 is connected to the digital-to-analog conversion module 184, the stepper motor 20 is connected to the relay module 185, the X-ray tube 10 is connected to the boost module 183, the battery 19 is connected to the power module 182, and the RF transmitter 15 is connected to the RF signal generator 188.

[0024] In this embodiment, the RF signal generator 188 is a crystal oscillator.

[0025] In this embodiment, the processing chip uses the STM32F103 micro processing chip, the digital-to-analog conversion module uses the DAC0832 digital-to-analog conversion chip, the analog-to-digital conversion module uses the DAC0864 analog-to-digital conversion chip, the power module uses the AMS1117-3.3V power chip, the relay module uses the G5V-1 micro relay, the constant current source drive module uses the TX6122 constant current source drive chip, and the boost module uses the DWP-01 20kV inverter boost module.

[0026] The specific application of the working of the device is as follows: the rat to be modeled is placed in the modeling activity chamber 6 above the irradiation plate 6, and then the box cover 2 is closed, the temperature in the box and the electromagnetic valve strength of the RF radio frequency signal of the RF radio frequency transmitter are set through the control panel 3, and the switch of the X-ray tube 10 is turned on by operating the button 5, and the processing chip 181 will output the instruction to the boost module 183, and the boost module will perform inversion boost and output a high voltage of 20kV to the X-ray tube, and the X-ray tube 10 will emit X-rays, and the X-rays will pass through the beam splitter 11, and the beam splitter 11 will split the X-rays to amplify the number of X-ray beams, and the split X-rays pass through the collimating lens, which is a single convex mirror, and the collimated X-rays refract the X-rays, and the collimated X-rays vertically pass through the irradiation plate 6 and irradiate the rats thereon with X-rays; the rats are induced with asthenozoospermia under the action of one or more inducing factors of temperature, electromagnetic radiation and X-ray radiation, thereby establishing an asthenozoospermia rat model.

[0027] In addition, the distance between the beam splitter and the X-ray tube can be controlled by operating buttons to adjust the radiation area of ​​the X-rays. After receiving the lifting command, the processing chip will output the corresponding command to the digital-to-analog conversion module, which will convert it into an analog electrical signal and transmit it to the relay module. The relay module will connect the forward or reverse circuit of the stepper motor, and the stepper motor will rotate forward or reverse and drive the lead screw to rotate forward or reverse, and the carrier plate threadedly connected to the lead screw will rise or fall.

[0028] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

Claims

1. A modeling device for asthenozoospermia rats, comprising a box body and a box cover, wherein the box cover is hinged to the front of the box body, and a control panel is fixed to the front of the box body, and a display screen and operation buttons are fixed to the control panel, wherein: A transparent irradiation plate is arranged in the box body, and the irradiation plate divides the box body into an upper modeling activity chamber and a lower radiation working chamber. A partition plate is fixed on the right side of the irradiation plate, and the chamber on the right side of the partition plate is an equipment chamber, in which a control circuit board and a battery are fixed, and the battery is connected to the control circuit board. An electric heating rod and a temperature acquisition sensor are fixed on the top of the modeling activity chamber, and an RF radio frequency transmitter is fixed on the side wall of the modeling activity chamber. A collimating lens, a beam splitter and an X-ray tube are fixed in the radiation working chamber, and the X-ray tube is fixed to the bottom of the radiation working chamber, and the beam splitter is fixed on the irradiation field adjustment mechanism. The electric heating rod, the temperature acquisition sensor, the RF radio frequency transmitter, the X-ray tube and the irradiation field adjustment mechanism are all connected to the control circuit board. The collimating lens is fixed to the bottom of the irradiation plate, and the irradiation field adjustment mechanism can adjust the distance between the beam splitter and the collimating lens to adjust the size of the X-ray radiation area.

2. The asthenozoospermia rat model making device according to claim 1, characterized in that: The irradiation field adjustment mechanism includes a pair of stepper motors, a pair of lead screws and a supporting plate. The lead screws are fixed on the rotating shaft of the stepper motor, are arranged on both sides of the supporting plate, pass through the supporting plate and are threadedly connected to the supporting plate, and the collimating lens is fixed at the center of the supporting plate.

3. The asthenozoospermia rat model making device according to claim 1 or 2, characterized in that: The collimating lens is a single convex mirror.

4. The asthenozoospermia rat model making device according to claim 3, characterized in that: The box body and the box cover are both composed of an inner radiation isolation layer, a middle heat preservation layer and an outer structural layer.

5. The asthenozoospermia rat model making device according to claim 4, characterized in that: The radiation isolation layer is made of lead plate, the thermal insulation layer is made of XPS plate, and the structural layer is made of stainless steel plate.

6. The asthenozoospermia rat model making device according to claim 4, characterized in that: A processing chip, a power module, a boost module, a digital-to-analog conversion module, a relay module, an analog-to-digital conversion module, a constant current source drive module and an RF radio frequency signal generator are fixed on the control circuit board. The power module, the boost module, the digital-to-analog conversion module, the analog-to-digital conversion module, the constant current source drive module and the RF radio frequency signal generator are all connected to the processing chip, the relay module is connected to the digital-to-analog conversion module, the stepper motor is connected to the relay module, the X-ray tube is connected to the boost module, the battery is connected to the power module, and the RF radio frequency transmitter is connected to the RF radio frequency signal generator.

7. The asthenozoospermia rat model making device according to claim 6, characterized in that: The RF radio frequency signal generator is a crystal oscillator.

Images