Online noninvasive lung function monitor for rodent rats and mice

Abstract

The invention relates to a rodent rat and mouse online noninvasive lung function monitor, and relates to the technical field of animal lung function monitoring and analysis systems, and the rodent rat and mouse online noninvasive lung function monitor comprises a fixed cylinder, a photoelectric signal sensor and a micro-pressure sensor; the fixed cylinder comprises an outer cylinder and an inner cylinder, the outer cylinder sleeves the outer side of the inner cylinder, and the inner cylinder and the outer cylinder are detachably connected; the front end of the inner cylinder extends to the outer side of the outer cylinder and is arranged in a gradually-shrinking mode, a connector is further arranged at the front end of the inner cylinder, and the connector is provided with an air supplementing opening communicated with the inner cylinder. A push rod is slidably connected to the outer cylinder and used for pushing an animal from the rear end of the inner cylinder to the front end of the inner cylinder. The photoelectric signal sensor is arranged at the front end of the inner cylinder, communicates with the inner cylinder and is used for detecting the change of an illumination environment in the front end of the inner cylinder; and the micro-pressure sensor is communicated with the outer cylinder and is used for detecting the pressure change in the fixed cylinder. By arranging the photoelectric signal sensor capable of detecting the sealing state of the fixed cylinder, automatic screening of detection signals is realized, and the accuracy of a detection result is effectively ensured.

Description

Technical Field

[0001] The present application relates to the field of animal lung function monitoring and analysis systems, and in particular to an online non-invasive lung function monitor for rodents and mice. Background Art

[0002] With the development of respiratory physiology and pharmacology research, accurate measurement of animal lung function related parameters has become increasingly important. It can not only promote the development of basic research on respiratory diseases, but also provide more support for clinical research. Traditional animal lung function monitoring methods, from direct observation to physiological recorders in recent years, have affected the accuracy of various parameter measurements during the experiment due to the mechanical damping of the recording paper to the pen, the nonlinearity of the recording, and the reading and calculation errors, making some research work on respiratory physiology and pharmacology unable to be scientifically and accurately evaluated.

[0003] In order to solve the above technical problems, a non-invasive airway mechanism monitoring system has been developed abroad, which calculates the specific airway resistance by monitoring the phase difference between the animal's nasal airflow and chest airflow through a dual chamber. However, existing devices designed based on the above principle (such as Chinese Patent 201811586256X, US Patent US 2011 / 0098581 A1, etc.) have certain problems: the chamber needs to be sealed by the animal itself during the test, but in the actual test process, even if the animal's limbs are restricted and fixed, the animal will inevitably move. Once it moves, the seal between the animal and the chamber will be destroyed and connected to the external environment. At this time, the test data is not very accurate. If the final test data includes relevant data when the seal is destroyed, it will affect the judgment of the final result. Summary of the invention

[0004] In view of the above problems, the present application is proposed to provide an online non-invasive lung function monitor for rodents and mice that overcomes the above problems or at least partially solves the above problems.

[0005] The present application provides an online non-invasive lung function monitor for rodents and mice using the following technical solutions: An online non-invasive lung function monitor for rodents, mice and rats, comprising a fixed cylinder, a photoelectric signal sensor and a micro-pressure sensor; the fixed cylinder comprises an outer cylinder and an inner cylinder for accommodating animals, the outer cylinder is sleeved on the outer side of the inner cylinder, and the inner cylinder and the outer cylinder are detachably connected; The front end of the inner tube extends to the outside of the outer tube and is arranged in a tapered shape, and the front end of the inner tube is also provided with a connector, and the connector is provided with an air inlet hole connected to the inner tube; The outer cylinder is slidably connected with a push rod, which is used to push the animal from the rear end of the inner cylinder to the front end of the inner cylinder; the outer cylinder is also connected with an air supply port and an air extraction port; The photoelectric signal sensor is arranged at the front end of the inner cylinder, and is used to detect changes in the internal lighting environment of the front end of the inner cylinder; The micro-pressure sensor is connected to the outer cylinder and is used to detect the pressure change in the fixed cylinder.

[0006] Optionally, a connecting cover is sleeved on the front end of the inner cylinder, and the connecting cover is plugged into the outer cylinder.

[0007] Optionally, the connector and the inner tube are plugged into each other, and a baffle is provided at the connection between the connector and the inner tube, and a through hole is provided on the baffle.

[0008] Optionally, the air inlet hole is a damping port.

[0009] Optionally, the micro-pressure sensor is arranged on the connecting head.

[0010] Optionally, a push plate with a fan-shaped cross-section is provided at the front end of the push rod.

[0011] Optionally, an annular column of a specific height is provided at the connection point between the micro-pressure sensor and the outer cylinder.

[0012] In summary, the present application includes the following beneficial technical effects: the present application realizes automatic screening of detection signals and effectively ensures the accuracy of detection results by setting a photoelectric signal sensor that can detect the sealing state of the fixed cylinder. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is a schematic diagram of the overall structure of an embodiment of the present application.

[0014] Figure 2 It is a cross-sectional schematic diagram of the overall structure of the embodiment of the present application.

[0015] Figure 3 yes Figure 2 A partial enlarged schematic diagram of area A in the middle.

[0016] Explanation of the reference numerals: 1. fixed cylinder; 11. outer cylinder; 111. push rod; 1111. push plate; 112. air supply port; 113. air exhaust port; 114. annular column; 12. inner cylinder; 2. photoelectric signal sensor; 3. micro-pressure sensor; 4. connecting cover; 5. connecting head; 51. air inlet hole; 6. baffle. DETAILED DESCRIPTION

[0017] In order to make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiment is one embodiment of the present invention, not all embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] Unless otherwise defined, technical or scientific terms used in the present invention shall have the common meanings understood by one having ordinary skills in the field to which the present invention belongs.

[0019] This embodiment provides an online non-invasive lung function monitor for rodents and mice.

[0020] Reference Figure 1 , Figure 2 , an online non-invasive lung function monitor for rodents and mice, comprising a fixing tube 1, a photoelectric signal sensor 2 and a micro-pressure sensor 3.

[0021] The fixed cylinder 1 includes an outer cylinder 11 and an inner cylinder 12 for accommodating animals, wherein the inner cylinder 12 is transparent, and one end is open, and both ends of the inner cylinder 12 are open; the inner cylinder 12 is inserted into the outer cylinder 11, and the inner cylinder 12 and the outer cylinder 11 are connected. At the same time, one end of the inner cylinder 12 extends to the outside of the outer cylinder 11 and is set in a tapered shape, and the front end of the inner cylinder 12 is also sleeved with a connecting cover 4 plug-in connected to the outer cylinder 11, so as to realize the convenient disassembly and assembly of the inner cylinder 12 and the outer cylinder 11, so as to load the animals into the inner cylinder 12. At the same time, a sealing ring can be provided at the plug-in connection between the outer cylinder 11 and the connecting cover 4 to ensure the airtightness of the fixed cylinder.

[0022] A push rod 111 is provided inside the outer tube 11 along its length direction. The push rod 111 is slidably connected to the rear end surface of the outer tube 11. The push rod 111 is used to push the animal located in the inner tube 12 from the rear end to the front end, so that the animal is in close contact with the front end of the inner tube 12 which is set in a tapered shape, and cooperates with the connecting cover 4 to achieve the sealing of the space inside the fixed tube 1. The front end of the push rod 111 is also provided with a push plate 1111 with a fan-shaped cross section, so as to increase the contact area between the push rod 111 and the tail of the animal, so as to facilitate the movement of the animal. In order to ensure the sealing of the fixed tube, a sealing ring is also provided at the sliding connection between the push rod 111 and the rear of the outer tube 11.

[0023] In order to realize the convenient connection between the fixed cylinder 1 and the exposure port of the exposure tower, a connector 5 is also provided at the front end of the inner cylinder 12, and an air inlet 51 connected to the inner cylinder 12 is provided on the connector 5. At the same time, in order to adapt to the fixation needs of animals of different sizes, the connector 5 is plugged into the front end of the inner cylinder 12, and a baffle 6 with a through hole is provided at the plug-in connection between the connector 5 and the inner cylinder 12, so as to realize the fixation needs of animals of different sizes by replacing the baffle 6 with different through hole sizes. At the same time, a sealing ring is also provided at the plug-in connection between the connector 5 and the inner cylinder 12 to ensure the sealing of the connection between the connector 5 and the inner cylinder, thereby ensuring the sealing of the fixed cylinder.

[0024] Reference Figure 1 , Figure 2 The outer cylinder 11 is also connected with an air supply port 112 and an air extraction port 113. The air extraction port 113 is used to extract the moisture and heat generated by the animal, and the air supply port 112 is used to supply air to prevent the accumulation of moisture and heat in the internal space of the fixed cylinder 1 from affecting the normal breathing state of the animal. In the actual implementation process, the preferred implementation scheme is that one air supply port 112 can be provided, and two air extraction ports 113 can be provided. The two air extraction ports 113 are distributed on both sides of the air supply port 112 to speed up the ventilation speed; The air supply port 112 is configured as a damping port to increase airflow damping, reduce the speed of airflow entering the fixed cylinder 1 , and thereby effectively reduce the impact on the air pressure in the fixed cylinder 1 during ventilation.

[0025] Reference Figure 2 , Figure 3 The photoelectric signal sensor 2 is arranged at the front end of the inner tube 12, and is used to detect the change of the internal light environment at the front end of the inner tube 12. In the specific implementation process, a pair of photoelectric signal sensors 2 are arranged, and the pair of photoelectric signal sensors 2 are distributed on both sides of the connector 5, and the two sides of the connector 5 are connected with through holes connected to the inner tube 12.

[0026] The micro-pressure sensor 3 is connected to the outer cylinder 11, and is used to detect the pressure change in the fixed cylinder 1. At the same time, a ring column 114 with a certain height is provided at the connection point between the micro-pressure sensor 3 and the outer cylinder 11 to ensure that urine produced by the animal does not enter the micro-pressure sensor 3, thereby ensuring the normal use state of the micro-pressure sensor 3.

[0027] When the animal's head position blocks the photoelectric signal sensor 2, the animal's head is in an extended state, which is defined as a sealed state; conversely, when the animal's head position does not block the photoelectric signal sensor 2, the animal's head is in a retracted state, which is defined as an unsealed state; the animal pressure signal detected by the micro-pressure sensor 3 at the unsealed state signal time node is discarded to facilitate subsequent signal data analysis and improve the accuracy of data analysis.

[0028] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. An online non-invasive lung function monitor for rodents and mice, characterized in that: The invention comprises a fixed cylinder (1), a photoelectric signal sensor (2) and a micro-pressure sensor (3); the fixed cylinder (1) comprises an outer cylinder (11) and an inner cylinder (12) for accommodating an animal, the outer cylinder (11) is sleeved on the outer side of the inner cylinder (12), and the inner cylinder (12) and the outer cylinder (11) are detachably connected; The front end of the inner cylinder (12) extends to the outside of the outer cylinder (11) and is arranged in a tapered shape, and a connector (5) is also arranged at the front end of the inner cylinder (12), and the connector (5) is provided with an air inlet (51) connected to the inner cylinder (12); The outer cylinder (11) is slidably connected with a push rod (111), and the push rod (111) is used to push the animal from the rear end of the inner cylinder (12) to the front end of the inner cylinder (12); the outer cylinder (11) is also connected with an air supply port (112) and an air extraction port (113); The photoelectric signal sensor (2) is arranged at the front end of the inner cylinder (12) and is used to detect changes in the internal lighting environment at the front end of the inner cylinder (12); The micro-pressure sensor (3) is connected to the outer cylinder (11) and is used to detect pressure changes in the fixed cylinder (1).

2. The online non-invasive lung function monitor for rodents and mice according to claim 1, characterized in that: A connecting cover (4) is sleeved on the front end of the inner cylinder (12), and the connecting cover (4) and the outer cylinder (11) are plugged together.

3. The online non-invasive lung function monitor for rodents and mice according to claim 1, characterized in that: The connecting head (5) and the inner tube (12) are plugged together, and a baffle (6) is provided at the connection between the connecting head (5) and the inner tube (12), and a through hole is provided on the baffle (6).

4. The online non-invasive lung function monitor for rodents and mice according to claim 1, characterized in that: The air supply port (112) is a damping port.

5. The online non-invasive lung function monitor for rodents and mice according to claim 1, characterized in that: The micro-pressure sensor (3) is arranged on the connecting head (5).

6. The online non-invasive lung function monitor for rodents and mice according to claim 1, characterized in that: A push plate (1111) having a fan-shaped cross section is arranged at the front end of the push rod (111).

7. The online non-invasive lung function monitor for rodents and mice according to claim 1, characterized in that: An annular column (114) of a specific height is provided at the connection point between the micro-pressure sensor (3) and the outer cylinder (11).

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