Traditional Chinese medicine atomizing agent with effect of relieving heart diseases and preparation method of traditional Chinese medicine atomizing agent

Abstract

The invention discloses a traditional Chinese medicine atomizing agent with the effect of relieving heart diseases and a preparation method of the traditional Chinese medicine atomizing agent. The traditional Chinese medicine atomizing agent is prepared from the following traditional Chinese medicine raw materials: 3-10 g of ginseng, 4-15 g of pseudo-ginseng, 3-12 g of borneol, 8-15 g of ligusticum wallichii, 3-10 g of ginkgo leaves, 3-12 g of rohdea japonica roots, 2-6 g of venenum bufonis, 1-5 g of rhizoma curcumae longae, 5-8 g of long-noded pit viper and 10-15 g of mint. The selected traditional Chinese medicinal materials have the effects of promoting blood circulation to remove blood stasis, dredging channels and collaterals, tranquilizing mind by nourishing the heart and the like, the medicines rapidly enter the lung through the respiratory tract in an atomization mode and rapidly reach the heart through blood circulation, pertinence is high, rapid permeation and absorption of the medicines are achieved, the utilization rate of the medicines is increased, and the curative effect is rapidly exerted; the symptoms of patients with heart diseases are obviously improved, the body functions of the patients are regulated, and the recurrence rate of the diseases is reduced.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine atomizer capable of alleviating heart diseases and a preparation method thereof. Background Art

[0002] Heart disease, also known as cardiovascular disease, refers to diseases involving the heart, blood vessels and their regulatory systems. These diseases affect the heartbeat, blood circulation and oxygen delivery. Heart disease is often accompanied by symptoms such as chest pain, chest tightness, and difficulty breathing, which seriously affect the patient's daily life and work. Patients require long-term treatment and care, which will also bring a heavy financial burden to the patient's family. If not treated in time, it may gradually worsen, causing damage to heart function and even endangering life. Therefore, timely relief of heart disease symptoms can prevent further deterioration of the disease and reduce the risk of death.

[0003] In the treatment of heart disease, although traditional Western medicine treatments can relieve symptoms to a certain extent and have quick effects, they are prone to relapse and the human body is also prone to drug resistance. Long-term use will bring a series of side effects, such as headaches, nausea, and blood pressure fluctuations. According to Chinese medicine theory, the pathogenesis of heart disease is often related to factors such as qi stagnation, blood stasis, and phlegm. Therefore, the use of traditional Chinese medicine for treatment has unique advantages. At present, the course of traditional Chinese medicine treatment is relatively long. It is an important issue to seek a treatment that is highly safe, short in course, and quick in effect. Summary of the invention

[0004] In view of the defects of the prior art, the present invention provides a Chinese medicine atomizer having the effect of alleviating heart disease and a preparation method thereof. Chinese medicine atomization is a new type of Chinese medicine administration method. The Chinese medicine liquid is atomized into small molecule aerosol through ultrasonic atomization technology, which is inhaled into the lungs along with oxygen, so that the medicine quickly enters the blood circulation and reaches the heart, thereby exerting a therapeutic effect.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] On the one hand, the present invention provides a traditional Chinese medicine atomizer having the effect of alleviating heart disease, wherein the traditional Chinese medicine atomizer is composed of the following traditional Chinese medicine raw materials: ginseng, Panax notoginseng, borneol, Chuanxiong, ginkgo leaf, dieffenbachia root, toad venom, turmeric, Agkistrodon acutus, and mint.

[0007] Preferably, the above-mentioned traditional Chinese medicine nebulizer with the effect of alleviating heart disease contains the following weight ratios: 3-10g ginseng, 4-15g Panax notoginseng, 3-12g borneol, 8-15g Chuanxiong, 3-10g Ginkgo biloba, 3-12g Dieffenbachia root, 2-6g Toad venom, 1-5g Curcuma longa, 5-8g Agkistrodon acutus, and 10-15g mint.

[0008] Preferably, the above-mentioned traditional Chinese medicine nebulizer with the effect of alleviating heart disease contains the following weight ratios: 3g ginseng, 4g Panax notoginseng, 3g borneol, 8g Chuanxiong, 3g Ginkgo biloba leaves, 3g Dieffenbachia root, 2g Toad venom, 1g Curcuma longa, 5g Agkistrodon acutus, and 10g mint.

[0009] Preferably, the above-mentioned traditional Chinese medicine nebulizer with the effect of alleviating heart disease contains the following weight ratios: 5g ginseng, 10g Panax notoginseng, 10g borneol, 10g Chuanxiong, 7g Ginkgo biloba, 6g Dieffenbachia root, 4g Toad venom, 3g Curcuma longa, 6g Agkistrodon, and 12g mint.

[0010] Preferably, the above-mentioned traditional Chinese medicine nebulizer with the effect of alleviating heart disease contains the following weight ratios: 10g ginseng, 15g Panax notoginseng, 12g borneol, 15g Chuanxiong, 10g Ginkgo biloba, 12g Dieffenbachia root, 6g Toad venom, 5g Curcuma longa, 8g Agkistrodon acutus, and 15g mint.

[0011] Preferably, the Chinese medicine aerosol for alleviating heart disease has the following effects and pharmacological effects:

[0012] Ginseng: sweet, slightly bitter, slightly warm in nature, enters the spleen, lung, heart, and kidney meridians. It can increase myocardial contractility, slow down heart rate, increase cardiac output and coronary blood flow, improve myocardial ischemia and arrhythmia, lower blood sugar, resist fatigue, and enhance the body's immune function.

[0013] Panax notoginseng: warm in nature, sweet and slightly bitter in taste, it enters the liver meridian and stomach meridian, has the effects of dispersing blood stasis and stopping bleeding, reducing swelling and relieving pain, anti-inflammatory and antibacterial, refreshing the mind, and improving immunity.

[0014] Ginkgo leaf: sweet, bitter, astringent, neutral in nature, enters the heart and lung meridians, has the effect of promoting blood circulation and removing blood stasis, has a good improvement effect on chest tightness, palpitations, shortness of breath, fatigue, can improve cardiac blood flow, protect ischemic myocardium, reduce triglycerides, etc. Dieffenbachia root: bitter, slightly sweet, cold, enters the heart and lung meridians, clears away heat and detoxifies, strengthens the heart and promotes diuresis, cools blood and stops bleeding.

[0015] Toad venom: sweet and spicy in taste, warm in nature, enters the liver, spleen, heart, and lung meridians, has the effects of detoxifying, killing insects, breaking up knots, relieving pain, and anti-tumor. It can increase cardiac output, lower heart rate, enhance myocardial contractility, and eliminate edema and dyspnea.

[0016] Turmeric: It tastes bitter and spicy, and is warm in nature. It has the effects of promoting qi and relieving pain, removing blood stasis and relieving menstruation, promoting digestion, anti-oxidation, and detoxification.

[0017] Borneol: It tastes bitter and acrid, enters the heart meridian, has a fragrant smell, and has the effects of antibacterial and anti-inflammatory, analgesic and antiseptic, invigorating the mind, clearing away heat and promoting tissue regeneration.

[0018] Agkistrodon acutus head: sweet, salty and warm in nature, Agkistrodon acutus has the effects of dispelling wind, dredging meridians and stopping spasms.

[0019] Chuanxiong: It has multiple pharmacological effects such as dilating coronary arteries, increasing coronary blood flow, reducing myocardial oxygen consumption, improving microcirculation, resisting cerebral ischemia, antipyretic, sedative, anti-tumor, anti-radiation, and regulating immunity.

[0020] Mint: It has many pharmacological effects such as diaphoresis, antipyretic, analgesia, sedation, anti-pathogen, antispasmodic, inhibition of gastrointestinal smooth muscle contraction, choleretic, stone removal, liver clearing and eyesight improvement, anti-inflammatory and antibacterial, and promoting transdermal absorption.

[0021] In another aspect, the present invention provides a Chinese medicine atomizer having the effect of alleviating heart disease and a preparation method thereof, comprising the following steps:

[0022] S1 weighing: weighing the above Chinese medicinal materials according to the weight ratio;

[0023] S2 Crushing: Pour the weighed Chinese medicine raw materials into the grinder and grind them into powder;

[0024] S3 sieving: the ground Chinese medicinal materials are passed through an 80-mesh sieve and extracted with boiling water under reflux for 1 hour;

[0025] S4 extraction: filter the extract, add ethanol to the extract, and precipitate overnight to increase the ethanol concentration;

[0026] S5 concentration: The water-extracted alcohol precipitate is centrifuged to obtain a clear liquid, which is then vacuum concentrated to obtain an extract concentrate;

[0027] S6 dissolution: dissolving the extract with propylene glycol to prepare a propylene glycol solution;

[0028] S7 prepares the finished product: propylene glycol is added to the propylene glycol solution, the propylene glycol accounts for 50%, and the remaining weight is supplemented with propylene glycol to prepare the atomized liquid.

[0029] Preferably, in step S4, ethanol needs to be added twice, and the two alcohol precipitations are carried out overnight.

[0030] Preferably, in step S4, the ethanol concentration needs to be increased from 40% to 70%.

[0031] Preferably, propylene glycol is added in step S7, the propylene glycol accounts for 50% of the total weight, and the remaining weight is supplemented by propylene glycol to obtain an atomized liquid.

[0032] Beneficial effects of the present invention:

[0033] The present invention provides a Chinese medicine atomizer with the function of relieving heart disease and a preparation method thereof. The selected Chinese medicinal materials have the functions of promoting blood circulation and removing blood stasis, unblocking meridians, nourishing the heart and calming the nerves, etc. Through the atomization technology, the Chinese medicine liquid is converted into fine particles, which quickly enter the lungs through the respiratory tract and quickly reach the heart through the blood circulation, thereby reducing the adverse reactions that may be caused by systemic medication, having strong pertinence, achieving rapid penetration and absorption of the drug, improving the utilization rate of the drug, being able to exert the therapeutic effect more quickly, significantly improving the symptoms of patients with heart disease, such as palpitations, chest tightness, shortness of breath, etc., regulating the patient's body function, and reducing the recurrence rate of the disease. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with embodiments. The embodiments of the present invention are only used to explain the present invention and are not intended to limit the present invention.

[0035] Embodiment 1

[0036] A traditional Chinese medicine atomizer with the effect of relieving heart disease comprises the following weight ratios: 3g ginseng, 4g notoginseng, 3g borneol, 8g chuanxiong, 3g ginkgo leaf, 3g dieffenbachia root, 2g toad venom, 1g turmeric, 5g acutus head, and 10g mint.

[0037] A Chinese medicine atomizer with the effect of relieving heart disease and a preparation method thereof: the above Chinese medicine raw materials are weighed according to the weight ratio, the weighed Chinese medicine raw materials are poured into a grinder and ground into powder, the ground Chinese medicine materials are sieved through an 80-mesh sieve, extracted with boiling water reflux for 1 hour, the extract is filtered, ethanol is added to the extract twice, and the two alcohol precipitations are carried out overnight to increase the ethanol concentration from 40% to 70%, the water-extracted alcohol precipitation is centrifuged to obtain a clear liquid, and the extract is concentrated by vacuum to obtain an extract, the extract is dissolved with propylene glycol to obtain a propylene glycol solution, glycerol is added to the propylene glycol solution, the glycerol accounts for 50%, and the remaining weight is supplemented with propylene glycol to obtain an atomized liquid.

[0038] Embodiment 2

[0039] A traditional Chinese medicine atomizer with the effect of relieving heart disease comprises the following weight ratios: 5g ginseng, 10g Panax notoginseng, 10g borneol, 10g Chuanxiong, 7g Ginkgo biloba leaves, 6g Dieffenbachia root, 4g Toad venom, 3g Curcuma longa, 6g Agkistrodon acutus, and 12g mint.

[0040] The preparation method is the same as that of Example 1.

[0041] Embodiment 3

[0042] A traditional Chinese medicine atomizer with the effect of relieving heart disease comprises the following weight ratios: 10g ginseng, 15g Panax notoginseng, 12g borneol, 15g Chuanxiong, 10g ginkgo leaf, 12g Dieffenbachia root, 6g toad venom, 5g Curcuma longa, 8g Agkistrodon acutus, and 15g mint.

[0043] The preparation method is the same as that of Example 1.

[0044] Comparative Example 1 (lack of ginseng)

[0045] A traditional Chinese medicine atomizer with the effect of relieving heart disease comprises the following weight ratios: 4g of Panax notoginseng, 3g of borneol, 8g of Chuanxiong, 3g of Ginkgo biloba leaves, 3g of Dieffenbachia oleifera root, 2g of Toad venom, 1g of Curcuma longa, 5g of Agkistrodon acutus, and 10g of mint.

[0046] The preparation method is the same as that of Example 1.

[0047] Comparative Example 2 (lack of ginkgo leaves)

[0048] A traditional Chinese medicine atomizer with the effect of relieving heart disease comprises the following weight ratios: 5g ginseng, 10g Panax notoginseng, 10g borneol, 10g Chuanxiong, 6g Dieffenbachia Root, 4g Toad Venom, 3g Curcuma longa, 6g Agkistrodon, and 12g mint.

[0049] The preparation method is the same as that of Example 1.

[0050] Comparative Example 3 (lacking mint and chuanxiong)

[0051] A traditional Chinese medicine atomizer with the effect of relieving heart disease comprises the following weight ratios: 10g ginseng, 15g notoginseng, 12g borneol, 10g ginkgo leaf, 12g dieffenbachia root, 6g toad venom, 5g turmeric, and 8g acutus head.

[0052] The preparation method is the same as that of Example 1.

[0053] The Chinese medicine aerosol prepared by the embodiments and comparative examples of the present invention is tested below. 90 people are randomly selected and divided into 6 groups, with 15 people in each group. The first group of people aerosolizes and inhales the Chinese medicine aerosol of embodiment 1, the second group of people aerosolizes and inhales the Chinese medicine aerosol of embodiment 2, the third group of people aerosolizes and inhales the Chinese medicine aerosol of embodiment 3, the fourth group of people aerosolizes and inhales the Chinese medicine aerosol of comparative example 1, the fifth group of people aerosolizes and inhales the Chinese medicine aerosol of comparative example 2, and the sixth group of people aerosolizes and inhales the Chinese medicine aerosol of comparative example 3. The symptoms of the test subjects include: heartache, chest tightness, palpitations, insomnia, panic, shortness of breath, dizziness, brain swelling, dyspnea, etc.

[0054] Nebulization method: Nebulization 3 times a day, 15 minutes each time, 5 days as a course of treatment.

[0055] After inhalation of nebulized liquid, the patients were followed up for 2 months and the number of people with significant effect, effective effect and ineffective effect was counted.

[0056] Effectiveness criteria: ① Significant effect: symptoms disappear; ② Effective: mild symptoms or prolonged intervals between symptom attacks; ③ Ineffective: no significant change in symptoms or worsening of symptoms.

[0057] Table 1 Experimental effects of embodiments and comparative examples on test population

[0058] Group Atomized liquid Significant effect Effective Effect invalid Efficiency Group 1 Example 1 Preparation 10 3 2 86％ Group 2 Example 2 Preparation 12 2 1 93％ Group 3 Example 3 Preparation 13 1 1 93％ Group 4 Comparative Example 1 Preparation 1 5 9 40％ Group 5 Comparative Example 2 Preparation 0 6 9 40％ Group 6 Comparative Example 3 Preparation 0 5 10 33％

[0059] In summary, the effectiveness of the population using the atomized medicinal solution prepared by Example 1, Example 2, and Example 3 is significantly higher than that using the medicinal solution prepared by Comparative Example 1, Comparative Example 2, and Comparative Example 3. The proportions of the various Chinese medicines of the present invention can quickly enter the medicine through the respiratory tract into the lungs by atomization, and quickly reach the heart through the blood circulation, with strong pertinence, achieving rapid penetration and absorption of the medicine, improving the utilization rate of the medicine, quickly exerting the therapeutic effect, and significantly improving the symptoms of patients with heart disease.

[0060] The above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. The present invention is described in detail. However, for those skilled in the art, modifications or equivalent substitutions of the technical solution of the present invention without departing from the purpose and scope of the technical solution of the present invention should be included in the scope of the claims of the present invention.

Claims

1. A Chinese medicine formula for alleviating heart disease, characterized in that: Contains the following Chinese medicinal ingredients: ginseng, Panax notoginseng, borneol, and Chuanxiong.

2. The Chinese medicine prescription for alleviating heart disease according to claim 1, characterized in that: The Chinese medicine formula also includes: ginkgo leaves, evergreen roots, toad venom, turmeric, snake head, and mint.

3. The Chinese medicine prescription for alleviating heart disease according to claim 2, characterized in that: It is prepared according to the following weight ratio: 3-10g ginseng, 4-15g Panax notoginseng, 3-12g borneol, 8-15g Chuanxiong, 3-10g ginkgo leaf, 3-12g Dieffenbachia root, 2-6g toad venom, 1-5g Curcuma longa, 5-8g Agkistrodon acutus, and 10-15g mint.

4. The Chinese medicine prescription for alleviating heart disease according to claim 3, characterized in that: It is prepared according to the following weight ratio: 3 or 10g ginseng, 4 or 15g Panax notoginseng, 3 or 12g borneol, 8 or 15g Chuanxiong, 3 or 10g Ginkgo biloba leaves, 3 or 12g Dieffenbachia root, 2 or 6g Toad venom, 1 or 5g Curcuma longa, 5 or 8g Agkistrodon acutus, and 10 or 15g mint.

5. The Chinese medicinal formula for alleviating heart disease according to claim 3 or 4, characterized in that: It is prepared according to the following weight ratio: 5g ginseng, 10g Panax notoginseng, 10g borneol, 10g Chuanxiong, 7g Ginkgo biloba leaves, 6g Dieffenbachia root, 4g Toad venom, 3g Curcuma longa, 6g Agkistrodon acutus, and 12g mint.

6. The method for preparing the Chinese medicine atomizer having the effect of alleviating heart disease according to claim 3, characterized in that The following steps are involved: S1 weighing: weighing the above Chinese medicinal materials according to the weight ratio; S2 Crushing: Pour the weighed Chinese medicine raw materials into the grinder and grind them into powder; S3 sieving: the ground Chinese medicinal materials are passed through an 80-mesh sieve and extracted with boiling water under reflux for 1 hour; S4 extraction: filter the extract, add ethanol to the extract, and precipitate overnight to increase the ethanol concentration; S5 concentration: the water-extracted alcohol precipitate is centrifuged to obtain a clear liquid, which is then vacuum concentrated to obtain an extract concentrate; S6 dissolution: the extract is dissolved in propylene glycol to obtain a propylene glycol solution; S7 prepares the finished product: propylene glycol is added to the propylene glycol solution, the propylene glycol accounts for 50%, and the remaining weight is supplemented with propylene glycol to prepare the atomized liquid.

7. The method for preparing the Chinese medicine atomized liquid having the effect of alleviating heart disease according to claim 6, characterized in that: In step S4, ethanol needs to be added twice, and the two alcohol precipitations are carried out overnight.

8. The method for preparing the Chinese medicine atomized liquid having the effect of alleviating heart disease according to claim 6, characterized in that: In step S4, the ethanol concentration needs to be increased from 40% to 70%.

9. The method for preparing the Chinese medicine atomized liquid having the effect of alleviating heart disease according to claim 6, characterized in that: In step S7, propylene glycol is added to make up the remaining weight to obtain an atomized liquid.