Novel administration method for eye administration

Abstract

The invention discloses a novel administration method for eye administration. The novel administration method specifically comprises the following steps: S1, filling a special solution bottle with a drug solution; s2, the solution bottle is aligned with the eyes to be used in the spraying process, medicine fog drops enter the eye liquid medicine bottle to be combined with an atomization device to be used, fine fog-shaped liquid drops are sprayed out through the atomization device, the particle size of the fog drops ranges from 0.1 micrometer to 60 micrometers, and the fog drops reach eyeballs and the peripheries of the eyes; s3, administration is performed in a medicine and mechanical combination mode during use, the medicine solution and the atomization device can be separately produced and prepared, and the medicine solution and the atomization device are combined during use. According to the novel administration method and atomization administration mode for eye administration, the medication treatment effect can be improved, the risk of eye infection caused by drugs is reduced, the discomfort of eyes during medication is improved, and the medication compliance of patients is improved.

Description

Technical Field

[0001] The invention relates to the technical field of ocular drug delivery, in particular to a novel method for ocular drug delivery. Background Art

[0002] With the change of people's lifestyle and living environment, the incidence of eye diseases is increasing. Eye drops are one of the most common treatments for eye diseases.

[0003] Traditional eye drops have high requirements for the eye drop method and complicated steps. If there is any deviation, it will not only fail to treat the disease, but also cause more damage to the eyes. Usually, when people use eye drops, they pull open the eyelids and drop them directly on the eyeball, then close their eyes and blink frequently to let the eye drops swirl in the eyes. This way of administration not only fails to achieve the effect of medication, but also easily causes the liquid medicine to irritate the cornea; closing the eyes forcefully and blinking more often can easily cause the liquid medicine to flow out and reduce the efficacy; if the hands are not cleaned and disinfected in advance when the lower eyelid is pulled open to apply the medicine, it is easy to cause eye infection; during the application process, the bottle mouth is easy to contact the eyelashes and the surface of the eye, causing bacteria to grow at the bottle mouth and then contaminate the medicine; after dripping the eye drops, the medicine covers the surface of the eyeball, causing blurred vision and discomfort for a period of time, and at the same time, some of the medicine is easy to flow from the nasolacrimal duct at the corner of the eye into the nasal cavity and throat, causing discomfort and irritation.

[0004] In addition, some special groups such as patients with cervical spondylosis, Parkinson's disease, and ataxia also have difficulty using traditional eye drops, and it is difficult to drop the medicine into the eyes. Summary of the invention

[0005] In view of the shortcomings of the prior art, the present invention provides a new method for ocular drug delivery, which solves the problems raised in the above-mentioned background technology.

[0006] To achieve the above objectives, the present invention is implemented by the following technical scheme: a new method for ocular drug delivery, specifically comprising the following steps: S1. Fill the drug solution into a special solution bottle; S2. During the spraying process, the solution bottle is aimed at the eyes to allow the drug droplets to enter the eyes. The solution bottle is used in combination with an atomizer to spray fine mist droplets through the atomizer. The droplet size is 0.1-30μm and reaches the eyeball and the periorbital area. S3. When in use, the drug is administered in a combined drug-device manner. The drug solution and the nebulizer device can be produced and prepared separately and used in combination.

[0007] Preferably, in S1, the material of the solution bottle is any one of glass, polyethylene, polypropylene, polyethylene terephthalate and metal bottle.

[0008] Preferably, in S1, the drug solution is eye drops for treating eye diseases.

[0009] The present invention also discloses a novel drug delivery device for eye drug delivery, wherein the atomizing device is composed of a main body and an atomizing unit. The main body is provided with a mounting cavity for accommodating the atomizing unit, a circuit board and a battery connected to the circuit board for electrical conduction are built into the main body, a switch is provided on the circuit board, a switch cap of the switch is placed outside the main body, an atomizing port is provided outside the main body, the atomizing port is connected to the mounting cavity, the atomizing unit is provided with a liquid inlet, a liquid container is detachably mounted on the liquid inlet, an atomizing sheet is assembled on the atomizing unit, one end face of the atomizing sheet is connected to the inner cavity of the liquid inlet, and the other end face of the atomizing sheet is placed outside the atomizing unit.

[0010] Preferably, after the atomizer unit is installed in the mounting cavity, the atomizer port is directly opposite to the outer end surface of the atomizer sheet; the atomizer unit and the circuit board are connected by a conductive member to form a connection; the mounting cavity of the atomizer device body and the atomizer unit are both provided with magnetic suction parts, the mounting cavity is provided with a conductive contact, and the atomizer unit is provided with a conductive ejector pin, which together constitute a conductive member; after the atomizer unit is installed in the mounting cavity, the conductive ejector pin and the conductive contact touch each other.

[0011] Preferably, the atomizer body has a built-in rechargeable battery and a circuit board, a charging interface is provided on the circuit board, the plug interface of the charging socket is placed on the outside of the body, an indicator light is also integrated on the circuit board, and a light guide block is provided on the outside of the body relative to the indicator light, and the inner end of the light guide block is facing the indicator light.

[0012] Preferably, the atomizer unit includes a base and a bottom plate, the liquid inlet is arranged on the base, and the liquid inlet is connected to the liquid container by a thread; a slot for inserting the atomizer sheet and the size of which is adapted to the atomizer sheet is provided in the inner cavity of the base, and the slot is respectively provided with an inlet and an outlet, and after the atomizer sheet is inserted into the slot, the inlet and outlet of the slot meet the requirements of liquid entry and atomization discharge of the atomizer sheet; the bottom plate is detachably covered at the inner cavity opening of the base, and the atomizer sheet inserted in the atomizer unit is a lead-free pressure-sensitive ceramic atomizer sheet.

[0013] Preferably, the atomizing device is a mesh atomizing device. Beneficial Effects

[0014] The present invention provides a novel method for ocular drug administration. Compared with the prior art, it has the following beneficial effects: This novel method of ocular drug administration can accelerate drug absorption by delivering eye drops to the eyes after atomization, so that the drug solution is evenly distributed and attached to the eyeball; during the drug administration process, the distance between the mist outlet and the eye is controlled to be 2-15 cm, the atomization rate is 0.1-2 ml / min, the drug dose delivered to the eye each time is 20-300 mg, and the number of medications per day is 1-10 times; compared with traditional eye drops, atomization drug administration can reduce drug loss and reduced efficacy caused by the drug solution flowing out of the corner of the eye due to accumulation in the eye; during use, there is no need to pry open the eyelids with hands, avoiding eye infections caused by hand hygiene; during use, the contact between the mouth of the medicine bottle and the eyelashes and the ocular surface is avoided, reducing the risk of drug contamination; at the same time, the droplet size of the atomization drug administration method is small and the force reaching the eyeball is gentle, avoiding the impact of the drug solution on the eyeball during medication, and reducing the discomfort of the patient during medication; for patients with difficulty in medication, such as cervical spondylosis patients, Parkinson's patients, ataxia patients, etc., their difficulties in eye drops can be solved.

[0015] The atomization drug administration method provided by the present invention can improve the therapeutic effect of medication, reduce the risk of drug-induced eye infection, improve eye discomfort during medication, and improve patient medication compliance. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the structure of the atomization device of the present invention. DETAILED DESCRIPTION

[0017] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] See also Figure 1 The present invention provides a technical solution: a novel method for ocular drug delivery, which specifically comprises the following steps: S1. Fill the drug solution into a special solution bottle; S2. During the spraying process, the solution bottle is aimed at the eyes to allow the drug droplets to enter the eyes. The solution bottle is used in combination with an atomizer to spray fine mist droplets through the atomizer. The droplet size is 0.1-60μm and reaches the eyeball and the periorbital area. S3. When in use, the drug is administered in a combined drug-device manner. The drug solution and the nebulizer device can be produced and prepared separately and used in combination.

[0019] S4. During drug administration, the distance between the mist outlet and the eyes is controlled to be 2-15 cm, the atomization rate is 0.1-2 ml / min, the dose of drug delivered to the eyes each time is 20-300 mg, and the number of times of medication per day is 1-10 times.

[0020] Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0021] Specifically, in S1, the material of the solution bottle is any one of glass, polyethylene, polypropylene, polyethylene terephthalate and metal bottle.

[0022] Specifically, in S1, the drug solution is eye drops for treating eye diseases.

[0023] The present invention also discloses a novel drug delivery device for eye drug delivery, wherein the atomizing device is composed of a main body and an atomizing unit. The main body is provided with a mounting cavity for accommodating the atomizing unit, a circuit board and a battery connected to the circuit board for electrical conduction are built into the main body, a switch is provided on the circuit board, a switch cap of the switch is placed outside the main body, an atomizing port is provided outside the main body, the atomizing port is connected to the mounting cavity, the atomizing unit is provided with a liquid inlet, a liquid container is detachably mounted on the liquid inlet, an atomizing sheet is assembled on the atomizing unit, one end face of the atomizing sheet is connected to the inner cavity of the liquid inlet, and the other end face of the atomizing sheet is placed outside the atomizing unit.

[0024] Specifically, after the atomizer unit is installed in the mounting cavity, the atomizer port is directly opposite to the outer end surface of the atomizer sheet; the atomizer unit and the circuit board are connected by a conductive member to form a connection; the mounting cavity of the atomizer device body and the atomizer unit are both provided with magnetic suction parts, the mounting cavity is provided with a conductive contact, and the atomizer unit is provided with a conductive ejector pin, which together constitute a conductive member; after the atomizer unit is installed in the mounting cavity, the conductive ejector pin and the conductive contact touch each other.

[0025] When the switch cap is turned on, the atomization port is exposed, the atomization unit is connected to the power supply and works; when the switch cap is turned off, the power supply is disconnected, the atomization unit stops working, and the switch cap covers the atomization port.

[0026] Specifically, the atomizer body has a built-in rechargeable battery and a circuit board, the circuit board is provided with a charging interface, the charging socket interface is placed outside the body, an indicator light is also integrated on the circuit board, and a light guide block is provided on the outside of the body relative to the indicator light, and the inner end of the light guide block faces the indicator light.

[0027] Specifically, the atomizer unit includes a base and a bottom plate, the liquid inlet is arranged on the base, and the liquid inlet is connected to the liquid container by a thread; a slot for inserting the atomizer sheet and the size of which is adapted to the atomizer sheet is arranged in the inner cavity of the base, and the slot is respectively provided with an inlet and an outlet, and after the atomizer sheet is inserted into the slot, the inlet and outlet of the slot meet the requirements of liquid entry and atomization discharge of the atomizer sheet; the bottom plate is detachably covered at the inner cavity opening of the base, and the atomizer sheet inserted in the atomizer unit is a lead-free pressure-sensitive ceramic atomizer sheet.

[0028] Specifically, the atomizing device is a mesh atomizing device.

[0029] The working principle of the mesh atomizer device: Slide the key switch downward, the magnet on the key triggers the Hall switch on the mainboard, the Hall switch gives an electrical signal to the control IC, and the control IC starts to power on. The control IC controls the battery power supply, and generates a high-frequency voltage signal through the resonant circuit on the mainboard to drive the lead-free varistor ceramic atomizer assembly to vibrate at high frequency. The high-frequency vibration of the lead-free varistor ceramic drives the atomizer to vibrate at high frequency. The high-frequency vibration of the atomizer causes the liquid on one side of the atomizer to diffuse to the other side of the atomizer through the micropores on the atomizer at high speed, forming continuous mist-like liquid particles with a median diameter of 3μm-20μm.

[0030] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0031] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A novel method for ocular administration, characterized in that: The specific steps include: S1. Fill the drug solution into a special solution bottle; S2. During the spraying process, the solution bottle is aimed at the eyes to allow the drug droplets to enter the eyes. The solution bottle is used in combination with an atomizer to spray fine mist droplets through the atomizer. The droplet size is 0.1-60μm and reaches the eyeball and the periorbital area. S3. When in use, the drug is administered in a combined drug-device manner. The drug solution and the nebulizer device can be produced and prepared separately and used in combination.

2. A novel method for ocular drug delivery according to claim 1, characterized in that: In S1, the material of the solution bottle is any one of glass, polyethylene, polypropylene, polyethylene terephthalate and metal bottle.

3. A novel method for ocular drug delivery according to claim 1, characterized in that: In S1, the drug solution is eye drops for treating eye diseases.

4. The eye diseases according to claim 3 include refractive system diseases (myopia, hyperopia, astigmatism), ocular surface diseases (dry eye, conjunctivitis, keratitis), fundus diseases (retinal detachment, maculopathy, retinal diseases), lens diseases (glaucoma, cataracts), optic nerve conduction diseases (optic atrophy, optic neuritis, anterior ischemic optic neuropathy).

5. A novel method for ocular drug delivery according to claim 1, characterized in that: In the S2, the distance between the mist outlet and the eyes is 2-15 cm, the atomization rate is 0.1-2 ml / min, the dose of the drug delivered to the eyes each time is 20-300 mg, and the number of times of medication per day is 1-10.

6. A novel drug delivery device for ocular administration, comprising a novel drug delivery method for ocular administration according to any one of claims 1 to 3, characterized in that: The atomizer device consists of a main body and an atomizer unit. The main body is provided with a mounting cavity for accommodating the atomizer unit. A circuit board and a battery connected to the circuit board for electrical conduction are built into the main body. A switch is provided on the circuit board. A switch cap of the switch is placed outside the main body. An atomizer port is provided outside the main body. The atomizer port is connected to the mounting cavity. The atomizer unit is provided with a liquid inlet. A liquid container is detachably mounted on the liquid inlet. An atomizer sheet is assembled on the atomizer unit. One end face of the atomizer sheet is connected to the inner cavity of the liquid inlet. The other end face of the atomizer sheet is placed outside the atomizer unit.

7. A novel drug delivery device for eye drug delivery according to claim 4, characterized in that: After the atomizer unit is installed in the mounting cavity, the atomizer port is directly opposite to the outer end surface of the atomizer sheet; the atomizer unit and the circuit board are connected by a conductive member to form a connection; the mounting cavity of the atomizer device body and the atomizer unit are both provided with magnetic suction parts, the mounting cavity is provided with a conductive contact, and the atomizer unit is provided with a conductive ejector pin, which together constitute a conductive member; after the atomizer unit is installed in the mounting cavity, the conductive ejector pin and the conductive contact touch each other.

8. A novel drug delivery device for eye drug delivery according to claim 4, characterized in that: The atomizer body has a built-in rechargeable battery and a circuit board. The circuit board is provided with a charging interface. The plug interface of the charging socket is placed outside the body. An indicator light is also integrated on the circuit board. A light guide block is provided outside the body relative to the indicator light, and the inner end of the light guide block faces the indicator light.

9. A novel drug delivery device for eye medication according to claim 4, characterized in that: The atomizer unit includes a base and a bottom plate, the liquid inlet is arranged on the base, and the liquid inlet is connected to the liquid container by a thread; a slot for inserting the atomizer sheet and the size of which is adapted to the atomizer sheet is arranged in the inner cavity of the base, and the slot is respectively provided with an inlet and an outlet, and after the atomizer sheet is inserted into the slot, the inlet and outlet of the slot meet the requirements of liquid entry and atomization discharge of the atomizer sheet; the bottom plate is detachably covered at the inner cavity opening of the base, and the atomizer sheet inserted in the atomizer unit is a lead-free pressure-sensitive ceramic atomizer sheet.

10. The novel drug delivery device for eye drug delivery according to claim 4, characterized in that: The atomizing device is a net-type atomizing device.

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