Composition for improving immunity of human body and application thereof

Abstract

The invention relates to a composition for improving the immunity of a human body and application of the composition, and relates to the technical field of medicines and health care products. , 50-80 parts of rabdosia serra, 15-35 parts of burdock root, 5-10 parts of zymosan and 10-20 parts of clinacanthus nutans. The composition provided by the invention takes rabdosia lingua as a core component and is matched with a proper amount of burdock root, clinacanthus nutans and the like, and all the components cooperate with one another, so that the composition has a remarkable effect of improving immunity. In addition, the selected raw materials are derived from the idea of homology of medicine and food, so that the safety and acceptability of the composition are ensured. Due to the characteristic, the compound is not only suitable for developing treatment medicines for specific people with low immunity, but also widely suitable for preparing various health-care products, such as dietary supplements and functional foods, so that the diversified requirements of different consumer groups on healthy life are met, and the compound has a wide application range.

Description

Technical Field

[0001] The present invention relates to the technical field of medicine and health care products, and in particular to a composition for improving human immunity and application thereof. Background Art

[0002] In today's society, with the accelerated pace of life and increased work pressure, people's health problems are becoming increasingly prominent, among which low immunity has become a focus of general concern. Immunity is an important line of defense for the human body to resist the invasion of external pathogens and maintain the stability of the internal environment. Its strength is directly related to the individual's health status and susceptibility to diseases. Therefore, how to effectively improve human immunity has become an important topic for the medical community and the health care products industry to explore together.

[0003] Traditionally, improving immunity mainly relies on methods such as drug treatment, nutritional supplements and physical exercise. However, drug treatment may have side effects, and long-term use may cause additional burden on the human body; although nutritional supplements are safe, the effects often vary from person to person and require long-term persistence; physical exercise is limited by personal physique and time arrangements, and is difficult to promote universally. Therefore, it is particularly important to find a safe, effective and easy way to improve immunity.

[0004] In the treasure house of traditional Chinese medicine, there are abundant natural plant resources. These plants have been proven to have the effect of regulating human immune function and enhancing physical fitness through thousands of years of practice. In recent years, with the development of modern science and technology, more and more studies have begun to focus on the immune regulation of these natural plant ingredients and try to apply them in the field of medicine and health products.

[0005] Isodon lophanthoides var.gerardianus, also known as "wild sesame", "stone lump", "sandworm leaf", "white thread grass", etc., is a perennial delicate herb belonging to the genus Isodon of the family Lamiaceae. The young leaves of Isodon lophanthoides are rich in vitamin C, β-carotene and minerals (such as calcium, iron, magnesium, etc.), as well as a variety of aromatic components, which give it a unique flavor and aroma. This makes it not only useful as a medicinal material, but also as a nutritious food ingredient with a wide range of uses.

[0006] Burdock root, derived from the root of Arctium lappa L., also known as burdock root, rat sticky root, burdock vegetable, etc. Burdock root is a plant resource with rich medicinal value and nutrients. It has been widely used in traditional Chinese medicine and food fields. For example, sliced ​​and dried burdock root can be soaked in water as tea, or washed and sliced ​​burdock root can be eaten directly or dipped in salad dressing, sesame paste, etc.

[0007] Clinacanthus nutans (Burm.f.) Lindau, also known as Worry Escape Grass, Soft Thorn Grass, Green Arrow, Sabah Snake Grass, Bamboo King (yellow), etc., is a herbaceous plant of the genus Clinacanthus in the family Acanthaceae. The whole plant of Clinacanthus nutans can be used as medicine, with the effects of regulating menstruation, removing blood stasis, reducing swelling, and relieving pain. It can be used to treat traumatic fractures, anemia, jaundice, rheumatism and other diseases. In addition, according to the "Guangxi Plant List" and modern pharmacological research, Clinacanthus nutans also has multiple pharmacological effects such as anti-cancer, antibacterial and anti-inflammatory, and antioxidant. In addition, the tender stems, leaves and shoots of Clinacanthus nutans can be eaten as vegetables, fried, cold, soup, and can also be boiled with pork bones. Its flowers are bright red and lovely, with a certain ornamental value, and can also be used as scented tea.

[0008] At present, there is no report in the prior art on the combined use of Glechoma longituba, burdock root and alligator flower for preparing products related to improving human immunity. Summary of the invention

[0009] In order to solve the above problems, the present invention provides a composition for improving human immunity and its application.

[0010] In a first aspect, the present invention provides a composition for improving human immunity, wherein the composition for improving human immunity comprises the following raw materials in parts by weight:

[0011] 50-80 parts of narrow-lined sedge, 15-35 parts of burdock roots, 5-10 parts of yeast polysaccharide and 10-20 parts of alligator mouth flower.

[0012] Furthermore, the composition for improving human immunity comprises the following raw materials in parts by weight:

[0013] 55-65 parts of narrow-lined sedge, 18-24 parts of burdock roots, 5-10 parts of yeast polysaccharide and 13-17 parts of alligator mouth flower.

[0014] Furthermore, the composition for improving human immunity comprises the following raw materials in parts by weight:

[0015] 60 parts of Herba Lycopodii Sinensis, 20 parts of Radix Burdockii, 7 parts of Yeast Polysaccharide and 15 parts of Alligator Mouth Flower.

[0016] Furthermore, the preparation method of the composition for improving human immunity comprises the following steps:

[0017] Adding the narrow-lined stalked sedge to petroleum ether for reflux extraction to obtain a first extract;

[0018] The burdock root and the alligator flower are subjected to supercritical extraction to obtain a second extract;

[0019] The first extract, the second extract and yeast polysaccharide are mixed and crushed, and then sieved to obtain the composition for improving human immunity.

[0020] Furthermore, the working condition parameters of the reflux extraction include: using petroleum ether with a boiling range of 60 to 90° C. as the extraction solvent, the extraction time is 1 to 2 hours, and the number of extractions is 1 to 3 times.

[0021] Furthermore, the weight ratio of the petroleum ether to the narrow-lined camellia sinensis is (5-10):1.

[0022] Furthermore, the working condition parameters of the supercritical extraction include: temperature of 60-75° C., pressure of 30-40 MPa, solvent of carbon dioxide fluid, and entrainer of 50-60% ethanol by volume.

[0023] Furthermore, the amount of the entrainer is 20-35wt% of the total weight of the burdock root and the alligator flower.

[0024] In a second aspect, the present invention provides the use of the composition for improving human immunity as described in any one of the first aspects in the preparation of immunity-enhancing drugs or immunity-enhancing health products.

[0025] The above technical solution provided by the embodiment of the present invention has at least the following advantages compared with the prior art:

[0026] The embodiments of the present invention provide a composition for improving human immunity and its application. The composition provided by the present invention uses narrow-lined striated camellia as the core ingredient, and is matched with an appropriate amount of burdock root and alligator mouth flower, etc. The components work together to have a significant effect on improving immunity. In addition, the raw materials selected by the present invention are all derived from the concept of "medicine and food are of the same origin", ensuring the safety and acceptability of the composition. This feature makes the present invention not only suitable for the development of therapeutic drugs for specific immunocompromised people, but also widely applicable to the preparation of various health products, such as dietary supplements, functional foods, etc., to meet the diversified needs of different consumer groups for healthy living, and has a wide range of uses. DETAILED DESCRIPTION

[0027] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution of the present invention will be clearly and completely described in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0028] Unless otherwise specified, various raw materials, reagents, instruments and equipment used in the present invention can be purchased from the market or prepared by existing methods.

[0029] In a first aspect, the present invention provides a composition for improving human immunity, wherein the composition for improving human immunity comprises the following raw materials in parts by weight:

[0030] 50-80 parts of narrow-lined sedge, 15-35 parts of burdock roots, 5-10 parts of yeast polysaccharide and 10-20 parts of alligator mouth flower.

[0031] The embodiment of the present invention provides a composition for improving human immunity. The composition provided by the present invention uses narrow-lined striated camellia as the core ingredient, and is matched with an appropriate amount of burdock root and alligator mouth flower, etc. The components work together to have a significant effect on improving immunity. In addition, the raw materials selected by the present invention are all derived from the concept of "medicine and food are of the same origin", ensuring the safety and acceptability of the composition. This feature makes the present invention not only suitable for the development of therapeutic drugs for specific immunocompromised people, but also widely applicable to the preparation of various health products, such as dietary supplements, functional foods, etc., to meet the diversified needs of different consumer groups for healthy living, and has a wide range of uses.

[0032] In some specific embodiments, the composition for improving human immunity comprises the following raw materials in parts by weight:

[0033] 55-65 parts of narrow-lined sedge, 18-24 parts of burdock roots, 5-10 parts of yeast polysaccharide and 13-17 parts of alligator mouth flower.

[0034] In some specific embodiments, the composition for improving human immunity comprises the following raw materials in parts by weight:

[0035] 60 parts of Herba Lycopodii Sinensis, 20 parts of Radix Burdockii, 7 parts of Yeast Polysaccharide and 15 parts of Alligator Mouth Flower.

[0036] In some specific embodiments, the method for preparing the composition for improving human immunity comprises the following steps:

[0037] Adding the narrow-lined stalked sedge to petroleum ether for reflux extraction to obtain a first extract;

[0038] The burdock root and the alligator flower are subjected to supercritical extraction to obtain a second extract;

[0039] The first extract, the second extract and yeast polysaccharide are mixed and crushed, and then sieved to obtain the composition for improving human immunity.

[0040] In some specific embodiments, the working condition parameters of the reflux extraction include: using petroleum ether with a boiling range of 60 to 90° C. as the extraction solvent, the extraction time is 1 to 2 hours, and the number of extractions is 1 to 3 times.

[0041] In some specific embodiments, the weight ratio of the petroleum ether to the narrow-lined sedge is (5-10):1.

[0042] In some specific embodiments, the working condition parameters of the supercritical extraction include: temperature of 60-75° C., pressure of 30-40 MPa, solvent of carbon dioxide fluid, and entrainer of 50-60% ethanol by volume.

[0043] In some specific embodiments, the amount of the entrainer is 20-35 wt % of the total weight of the burdock root and the alligator flower.

[0044] In some specific embodiments, the yeast polysaccharide can be directly used as commercially available products such as yeast-β-glucan (food grade), such as the manufacturer: Leiber Company of Germany.

[0045] In a second aspect, based on the same inventive concept, the present invention provides the use of the composition for improving human immunity as described in any one of the first aspects in the preparation of immunity-enhancing drugs or immunity-enhancing health products.

[0046] It should be noted that, if there is no specific description or special limitation, the raw materials involved in the composition for improving human immunity provided by the present invention and its application can be directly made from commercial products or made by oneself according to the existing public process. At the same time, the preparation method steps and process parameters involved, if there is no specific description or special limitation, can be carried out according to the process flow and parameters disclosed in the prior art or directly using existing equipment, and the present invention document will not repeat them one by one.

[0047] The present invention will be further described below in conjunction with specific examples. It should be understood that these examples are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental methods in the following examples that do not specify specific conditions are usually measured according to national standards. If there is no corresponding national standard, then the conditions recommended by the manufacturer are followed.

[0048] Example 1

[0049] This example provides a composition for improving human immunity. The composition for improving human immunity comprises the following raw materials in parts by weight:

[0050] 60 parts of Herba Lycopodii Sinensis, 20 parts of Radix Burdockii, 7 parts of yeast polysaccharide (specifically yeast-β-glucan) and 15 parts of Alligator Mouth Flower.

[0051] The preparation method of the composition for improving human immunity comprises the following steps:

[0052] Step (1): grind the whole herb of the narrow-lined sedge, mix it with petroleum ether with a boiling range of 60 to 90° C. in a weight ratio of 8:1, and perform reflux extraction; the extraction process is performed at a temperature of 95° C., each time lasting 1.5 hours, and a total of two extractions are performed to ensure sufficient extraction; thereafter, the solid is removed by filtration, and the obtained extract is concentrated and dried to obtain a first extract;

[0053] Step (2): Grinding the burdock root and the alligator flower raw materials and mixing them to form a composite powder; then, using supercritical extraction technology, at a temperature of 70° C. and a pressure of 35 MPa, using carbon dioxide fluid as a solvent, adding 55% ethanol with a volume fraction of 30% of the total weight of the raw materials as an entrainer, and extracting the composite powder; after the extraction is completed, collecting the extract, removing the entrainer by vacuum concentration, and drying to obtain a second extract;

[0054] Step (3): The first extract obtained in step (1), the second extract obtained in step (2) and yeast polysaccharide are mixed and crushed, and then passed through a 200-mesh sieve to obtain the composition for improving human immunity.

[0055] Example 2

[0056] This example provides a composition for improving human immunity. The composition for improving human immunity comprises the following raw materials in parts by weight:

[0057] 50 parts of Herba Lycopodii Sinensis, 15 parts of Radix Burdockii, 5 parts of yeast polysaccharide (specifically yeast-β-glucan) and 10 parts of Alligator Mouth Flower.

[0058] The preparation method of the composition for improving human immunity comprises the following steps:

[0059] Step (1): grind the whole herb of the narrow-lined sedge, mix it with petroleum ether with a boiling range of 60 to 90° C. in a weight ratio of 10:1, and perform reflux extraction; the extraction process is performed at a temperature of 95° C., each time lasting 1.5 hours, and a total of two extractions are performed to ensure sufficient extraction; thereafter, the solid is removed by filtration, and the obtained extract is concentrated and dried to obtain a first extract;

[0060] Step (2): Grinding the burdock root and the alligator flower raw materials and mixing them to form a composite powder; then, using supercritical extraction technology, at a temperature of 75° C. and a pressure of 40 MPa, using carbon dioxide fluid as a solvent, adding 50% ethanol with a volume fraction of 35% of the total weight of the raw materials as an entrainer, and extracting the composite powder; after the extraction is completed, collecting the extract, removing the entrainer by vacuum concentration, and drying to obtain a second extract;

[0061] Step (3): The first extract obtained in step (1), the second extract obtained in step (2) and yeast polysaccharide are mixed and crushed, and then passed through a 200-mesh sieve to obtain the composition for improving human immunity.

[0062] Example 3

[0063] This example provides a composition for improving human immunity. The composition for improving human immunity comprises the following raw materials in parts by weight:

[0064] 80 parts of Herba Lysimachiae, 35 parts of Radix Burdockae, 10 parts of yeast polysaccharide (specifically yeast-β-glucan) and 20 parts of Alligator Mouth Flower.

[0065] The preparation method of the composition for improving human immunity comprises the following steps:

[0066] Step (1): grind the whole herb of the narrow-lined sedge, mix it with petroleum ether with a boiling range of 60 to 90° C. in a weight ratio of 5:1, and perform reflux extraction; the extraction process is performed at a temperature of 95° C., each time lasting 1.5 hours, and a total of two extractions are performed to ensure sufficient extraction; thereafter, the solid is removed by filtration, and the obtained extract is concentrated and dried to obtain a first extract;

[0067] Step (2): Grinding the burdock root and the alligator flower raw materials and mixing them to form a composite powder; then, using supercritical extraction technology, at a temperature of 60° C. and a pressure of 30 MPa, using carbon dioxide fluid as a solvent, adding 60% ethanol with a volume fraction of 20% of the total weight of the raw materials as an entrainer, and extracting the composite powder; after the extraction is completed, collecting the extract, removing the entrainer by vacuum concentration, and drying to obtain a second extract;

[0068] Step (3): The first extract obtained in step (1), the second extract obtained in step (2) and yeast polysaccharide are mixed and crushed, and then passed through a 200-mesh sieve to obtain the composition for improving human immunity.

[0069] Comparative Example 1

[0070] This example provides an extract for improving human immunity, and the extract is the first extract in Example 1.

[0071] Comparative Example 2

[0072] This example provides an extract for improving human immunity, and the extract is the second extract in Example 1.

[0073] Comparative Example 3

[0074] This example provides a composition for improving human immunity, which is different from Example 1 only in that: in parts by weight, the composition for improving human immunity includes the following raw materials: 20 parts of narrow-lined camellia sinensis, 60 parts of burdock roots, 7 parts of yeast polysaccharide (specifically yeast-β-glucan) and 15 parts of alligator mouth flower; the remaining steps and parameters are the same.

[0075] The preparation method of the composition for improving human immunity comprises the following steps:

[0076] Step (1): grind the whole herb of the narrow-lined sedge, mix it with petroleum ether with a boiling range of 60 to 90° C. in a weight ratio of 8:1, and perform reflux extraction; the extraction process is performed at a temperature of 95° C., each time lasting 1.5 hours, and a total of two extractions are performed to ensure sufficient extraction; thereafter, the solid is removed by filtration, and the obtained extract is concentrated and dried to obtain a first extract;

[0077] Step (2): Grinding the burdock root and the alligator flower raw materials and mixing them to form a composite powder; then, using supercritical extraction technology, at a temperature of 70° C. and a pressure of 35 MPa, using carbon dioxide fluid as a solvent, adding 55% ethanol with a volume fraction of 30% of the total weight of the raw materials as an entrainer, and extracting the composite powder; after the extraction is completed, collecting the extract, removing the entrainer by vacuum concentration, and drying to obtain a second extract;

[0078] Step (3): The first extract obtained in step (1), the second extract obtained in step (2) and yeast polysaccharide are mixed and crushed, and then passed through a 200-mesh sieve to obtain the composition for improving human immunity.

[0079] Comparative Example 4

[0080] This example provides a composition for improving human immunity, which is different from Example 1 only in that the extraction solvent in step (1) is ethanol with a volume fraction of 80%; the remaining steps and parameters are the same.

[0081] This example provides a composition for improving human immunity. The composition for improving human immunity comprises the following raw materials in parts by weight:

[0082] 60 parts of Herba Lycopodii Sinensis, 20 parts of Radix Burdockii, 7 parts of yeast polysaccharide (specifically yeast-β-glucan) and 15 parts of Alligator Mouth Flower.

[0083] The preparation method of the composition for improving human immunity comprises the following steps:

[0084] Step (1): taking the whole herb of the narrow-lined sedge, crushing it, mixing it with 80% by volume ethanol in a weight ratio of 8:1, and performing reflux extraction; the extraction process is carried out at a temperature of 95° C., each time lasting 1.5 hours, and a total of two extractions are performed to ensure sufficient extraction; thereafter, the solid is removed by filtration, and the obtained extract is concentrated and dried to obtain a first extract;

[0085] Step (2): Grinding the burdock root and the alligator flower raw materials and mixing them to form a composite powder; then, using supercritical extraction technology, at a temperature of 70° C. and a pressure of 35 MPa, using carbon dioxide fluid as a solvent, adding 55% ethanol with a volume fraction of 30% of the total weight of the raw materials as an entrainer, and extracting the composite powder; after the extraction is completed, collecting the extract, removing the entrainer by vacuum concentration, and drying to obtain a second extract;

[0086] Step (3): The first extract obtained in step (1), the second extract obtained in step (2) and yeast polysaccharide are mixed and crushed, and then passed through a 200-mesh sieve to obtain the composition for improving human immunity.

[0087] Test Case

[0088] In this example, the effects of the compositions or extracts for improving human immunity prepared in Examples 1 to 3 and Comparative Examples 1 to 4 were evaluated based on the testing methods and processes disclosed in the prior art.

[0089] Test method: The test specification for enhancing immunity in the "Health Food Functional Evaluation Procedure and Test Method" was referred to, especially the ConA-induced mouse spleen lymphocyte transformation experiment (MTT method) was used to quantify the proliferation ability of lymphocytes as an indicator for evaluating immunity. The stronger the lymphocyte proliferation ability, the more significant the body's immunity. The experiment measured the optical density value at a wavelength of 570nm using a semi-automatic biochemical analyzer, and the proliferation activity of lymphocytes was reflected by the difference in optical density between the wells with ConA and the wells without ConA.

[0090] Experimental design:

[0091] 1. Grouping: 80 healthy mice were selected and randomly divided into 8 groups, 10 mice in each group, respectively:

[0092] Blank control group: No drug treatment was given, and only distilled water was gavage as the control solution.

[0093] Experimental groups 1 to 3: The aqueous solutions of the compositions obtained in Examples 1 to 3 were gavaged respectively, with the concentration uniformly set at 25 mg / mL.

[0094] Experimental groups 4 to 7 were respectively gavaged with aqueous solutions of the extracts or compositions obtained in Comparative Examples 1 to 4, with the same concentration of 25 mg / mL.

[0095] 2. Dosage regimen: All experimental groups were given drugs by gavage once a day. The gavage volume was adjusted to 20 ml / kg.BW based on the body weight of the mice. The gavage was continued for 30 days to ensure that the drug had a full effect and a stable physiological response was observed.

[0096] 3. Result record: After the experiment, collect and organize the data. The test results are shown in Table 1.

[0097] Table 1

[0098] Group Lymphocyte proliferation capacity Blank control group 0.179±0.098 Experimental Group 1 0.358±0.085 Experimental Group 2 0.291±0.103 Experimental Group 3 0.314±0.092 Experimental Group 4 0.216±0.109 Experimental Group 5 0.202±0.091 Experimental Group 6 0.247±0.094 Experimental Group 7 0.235±0.086

[0099] It can be seen from Table 1 that compared with comparative examples 1 to 4, the compositions provided by Examples 1 to 3 of the present invention have a more significant effect in providing immunity, and the first extract obtained from the narrow-lined camellia sinensis as raw material and the second extract obtained from the burdock root and alligator mouth flower as raw materials show a significant synergistic effect.

[0100] In summary, the embodiments of the present invention provide a composition for improving human immunity and its application. The composition provided by the present invention uses narrow-lined striated camellia as the core ingredient, and is matched with an appropriate amount of burdock root and alligator mouth flower, etc. The components work together to have a significant effect on improving immunity. In addition, the raw materials selected by the present invention are all derived from the concept of "medicine and food are of the same origin", ensuring the safety and acceptability of the composition. This feature makes the present invention not only suitable for the development of therapeutic drugs for specific immunocompromised people, but also widely applicable to the preparation of various health products, such as dietary supplements, functional foods, etc., to meet the diversified needs of different consumer groups for healthy living, and has a wide range of uses.

[0101] The foregoing is merely a specific embodiment of the present invention, which enables those skilled in the art to understand or implement the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features claimed herein.

Claims

1. A composition for improving human immunity, characterized in that: The composition for improving human immunity comprises the following raw materials in parts by weight: 50-80 parts of narrow-lined sedge, 15-35 parts of burdock roots, 5-10 parts of yeast polysaccharide and 10-20 parts of alligator mouth flower.

2. The composition for improving human immunity according to claim 1, characterized in that: The composition for improving human immunity comprises the following raw materials in parts by weight: 55-65 parts of narrow-lined sedge, 18-24 parts of burdock roots, 5-10 parts of yeast polysaccharide and 13-17 parts of alligator mouth flower.

3. The composition for improving human immunity according to claim 1, characterized in that: The composition for improving human immunity comprises the following raw materials in parts by weight: 60 parts of Herba Lycopodii Sinensis, 20 parts of Radix Burdockii, 7 parts of Yeast Polysaccharide and 15 parts of Alligator Mouth Flower.

4. The composition for improving human immunity according to any one of claims 1 to 3, characterized in that: The preparation method of the composition for improving human immunity comprises the following steps: Adding the narrow-lined stalked sedge to petroleum ether for reflux extraction to obtain a first extract; The burdock root and the alligator flower are subjected to supercritical extraction to obtain a second extract; The first extract, the second extract and yeast polysaccharide are mixed and crushed, and then sieved to obtain the composition for improving human immunity.

5. The composition for improving human immunity according to claim 4, characterized in that: The working condition parameters of the reflux extraction include: selecting petroleum ether with a boiling range of 60 to 90° C. as the extraction solvent, the extraction time is 1 to 2 hours, and the number of extractions is 1 to 3 times.

6. The composition for improving human immunity according to claim 5, characterized in that: The weight ratio of the petroleum ether to the narrow-lined camellia sinensis is (5-10):

1.

7. The composition for improving human immunity according to claim 6, characterized in that: The working condition parameters of the supercritical extraction include: temperature of 60-75° C., pressure of 30-40 MPa, solvent of carbon dioxide fluid, and entrainer of 50-60% ethanol by volume.

8. The composition for improving human immunity according to claim 7, characterized in that: The amount of the entrainer is 20-35 wt % of the total weight of the burdock root and the alligator flower.

9. Use of the composition for improving human immunity according to any one of claims 1 to 8 in the preparation of immunity-enhancing drugs or immunity-enhancing health products.