Design and preparation method of 3D printing porous titanium alloy prosthesis for large-segment bone defect reconstruction

Abstract

The invention provides a design and preparation method of a 3D printing porous titanium alloy prosthesis for large-segment bone defect reconstruction, which comprises a preparation method, and the preparation method comprises the following steps: step 1, acquiring bone defect data by adopting CT (Computed Tomography); according to the design and preparation method of the 3D printing porous titanium alloy prosthesis for large-segment bone defect reconstruction, during use, metal powder falls between the rollers through the connecting hopper, the rollers rotate inwards at the same time to complete primary extrusion of the metal powder, and after being subjected to primary extrusion, metal is laid on the supporting assembly along with movement of the movable box to complete later laser sintering; and in addition, secondary compaction of the metal powder is completed through the driven roller along with movement of the movable box.

Description

Technical Field

[0001] The present invention relates to the technical field of titanium alloy prosthesis preparation, and in particular to a design and preparation method of a 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects. Background Art

[0002] The preparation of titanium alloy prostheses needs to be printed by a metal powder printer. When using existing metal powder 3D printers, since laser beam sintering is adopted, the powder used for printing needs to be preheated. Currently, a heating element is generally used to preheat the powder in the piston cylinder. However, due to powder accumulation, the preheating time is long and the preheating effect is not uniform, which leads to a long printing processing time.

[0003] According to a patent document with an existing publication number of CN116275131A, a 3D printer based on metal powder is disclosed, which includes a rotating bearing, a pressure roller is fixedly sleeved in the middle of the rotating bearing, a heating chamber is opened inside the pressure roller, a spring is fixedly installed inside the heating chamber, a heat generating block is fixedly installed at one end of the spring, a heat conducting block is fixedly installed on the outer wall surface of the pressure roller, and a fixed shell is fixedly installed on the outside of one side of the pressure roller. When using this technical solution, by setting a heat generating block and a suction block, the centrifugal force generated by the rotation of the pressure roller is used to move the heat generating block outward, and the suction block is used to instantly adsorb the heat generating block, so that the heat generating block and the surface of the pressure roller have a strong impact, thereby generating a large amount of heat energy, which is then conducted in sequence through the heat conducting block. With respect to the above technical solution, although this solution realizes heat conduction, it is unable to complete the preliminary extrusion of the powder during the early powder laying. In addition, it is unable to perform secondary compaction during the later laying, which is inconvenient during use. Summary of the invention

[0004] In view of the shortcomings of the prior art, the purpose of the present invention is to provide a design and preparation method for a 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects, so as to solve the problems raised in the above-mentioned background technology. The present invention has a novel structure. When in use, metal powder falls between the rollers through the connecting bucket, and the rollers rotate inward at the same time to complete the initial extrusion of the metal powder. After the initial extrusion of the metal distribution, it is laid on the supporting assembly as the movable box moves to complete the subsequent laser sintering. In addition, as the movable box moves, the secondary compaction of the metal powder is completed by the driven roller.

[0005] In order to achieve the above-mentioned purpose, the present invention is implemented through the following technical scheme: a design and preparation method of a 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects, including a preparation method, wherein the preparation method comprises the following steps: step 1, using CT to obtain bone defect data; step 2, using CT three-dimensional bone image segmentation and modeling software developed based on mechanical principles to establish a high-precision three-dimensional model of the bone defect; step 3, using three-dimensional CAD software to parametrically design a personalized bone defect prosthesis so that it has an anatomical shape and internal porous structure that matches the bone defect, and at the same time realizes a rapid conversion of a discrete bone defect digital model to a parametric digital model; step 4, converting The model data is imported into the metal powder printer, and the medical spherical titanium alloy powder and printing process parameters independently developed by the team in the early stage are used to manufacture a personalized titanium alloy matrix; Step 5, a vacuum magnetron sputtering coating system is used to conduct tantalum coating experiments, and tantalum coatings of different thicknesses are prepared by optimizing the sputtering power, sputtering angle, argon gas pressure and sputtering time to ensure that the bond is firm and does not fall off; Step 6, a mechanical testing machine is used to conduct a compression mechanical test, and the coating thickness is measured by cutting the titanium-based tantalum coating cross-section sample with a high-speed precision cutting machine, and then the metallographic observation sample is prepared, and the coating thickness is measured by observation, and the X-ray photoelectron spectroscopy is used to test the coating distribution uniformity and thickness, and the coating coverage

[0006] The metal powder printer in step 4 is realized by a printing device body, which includes a fixed box, a printing box is fixed on the top of the fixed box, a cavity is opened inside the printing box, a dust suction port and a fixed groove are respectively opened on the inner wall of the cavity, a laying component is movably installed inside the fixed groove, a collecting box is fixedly installed on one side of the fixed box, a filter component and a discharge pipe are respectively fixedly installed on the sides of the collecting box, a connecting pipe is fixed between the collecting box and the printing box, and one end of the connecting pipe is connected to the dust suction port.

[0007] Furthermore, a laser box is fixedly installed on the top of the printing box, a controller is fixedly installed on the side of the printing box, an opening is opened on the other side of the printing box, and a sealing door is movably installed on the side of the opening.

[0008] Furthermore, a receiving cavity is opened on the inner wall of the cavity, and a support assembly is movably installed inside the receiving cavity. The support assembly includes a support seat, and a sealing ring is fixed to the side of the support seat, and the sealing ring is in contact with the inner wall of the receiving cavity.

[0009] Furthermore, a movable seat is movably mounted on the top of the support seat, and the movable seat is movably mounted on the support seat by bolts. A fixed column is welded to the bottom of the support seat, and a movable column is movably mounted on one end of the fixed column.

[0010] Furthermore, a lifting mechanism is installed at one end of the movable column, and the lifting mechanism is fixedly installed at one end of the storage cavity. A fixed cavity is opened at one end of the movable column, and a connecting column is movably installed inside the fixed cavity, and the connecting column is welded to one end of the fixed column.

[0011] Furthermore, an arc block is welded on the side of the connecting column, a positioning hole is opened on the arc block, a fixing block is welded inside the fixing cavity, a positioning column is welded on the bottom of the fixing block, and one end of the positioning column is movably installed inside the positioning hole.

[0012] Furthermore, a support mechanism is fixed inside the fixed cavity, a support plate is fixed at one end of the support mechanism, the support plate is movably in contact with one end of a connecting column, an annular tube is fixed on the side of the storage cavity, a pipe is fixed on one side of the annular tube, and one end of the pipe is fixed on the collection box.

[0013] Furthermore, the laying assembly includes a movable box, a fixed tube is fixed to the side of the movable box, the fixed tube is connected to an external feed hose, a displacement mechanism is fixedly installed on the fixed tube, the displacement mechanism is fixedly installed on the printing box, a mounting hole is opened on the side of the movable box, and a power mechanism is fixedly installed inside the mounting hole.

[0014] Furthermore, a feed pipe is fixedly installed between the fixed pipes, the feed pipe is fixedly installed inside the movable box, a heating mechanism is fixedly installed on the side of the feed pipe, and a connecting bucket is fixedly installed at the bottom of the feed pipe.

[0015] Furthermore, a roller is rotatably installed inside the movable box, the roller is installed on the power mechanism, the connecting bucket is installed between the rollers, a heating block and a scraper are respectively fixed on the inner wall of the movable box, a driven roller is rotatably installed inside the movable box, the driven roller is rotatably installed at the bottom of the roller, the heating block is installed on the top of the roller, and the scraper is installed at the bottom of the roller.

[0016] Beneficial effects of the invention: The design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects of the invention comprises a fixing box; a printing box; a controller; a collecting box; a filtering assembly; a discharge pipe; a connecting pipe; a laser box; a sealing door; a cavity; a dust suction port; a fixing groove; a laying assembly; a supporting assembly; an opening; a supporting seat; a sealing ring; a movable seat; a bolt; a fixing column; a movable column; a lifting mechanism; a connecting column; an arc block; a receiving cavity; a ring tube; a pipeline; a fixing cavity; a supporting mechanism; a supporting plate; a positioning hole; a fixing block; a positioning column; a movable box; a fixing pipe; a displacement mechanism; a mounting hole; a power mechanism; a feeding pipe; a heating mechanism; a heating block; a connecting bucket; a roller; a scraper; and a driven roller.

[0017] 1. The design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects is as follows: when in use, metal powder falls between the rollers through the connecting bucket, and the rollers rotate inward at the same time to complete the initial extrusion of the metal powder. After the initial extrusion of the metal distribution, it is laid on the supporting component as the movable box moves to complete the subsequent laser sintering. In addition, as the movable box moves, the secondary compaction of the metal powder is completed by the driven roller.

[0018] 2. The design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects is as follows: before the metal powder falls into the drum, the feeding tube is wrapped and heated by a heating mechanism to achieve initial temperature increase of the metal powder inside the feeding tube; when the metal powder falls from the connecting bucket between the drums, the heating block heats the drum, and the high temperature on the drum is used to perform secondary temperature increase of the metal powder; the drum moves on a scraper, and the scraper facilitates scraping off the powder adhering to the drum.

[0019] 3. The design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects, an exhaust fan is installed inside the dust suction port, the exhaust fan generates a breeze, the breeze absorbs the dust floating inside the cavity, after the printing is completed, the lifting mechanism drives the support seat to move to the bottom of the storage cavity, and the external exhaust mechanism cooperates with the discharge pipe to generate suction, which is transmitted to the inside of the pipe through the collection box. The pipe absorbs the dust on the movable seat through the ring pipe and collects it in the external collection device, which is convenient for the reuse of metal powder in the later stage. A large amount of dust is collected before the printed prosthesis is taken out, thereby avoiding the harm of metal powder to the human body. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 A schematic diagram of the structure of the design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects of the present invention;

[0021] Figure 2 A schematic diagram of the structure of the cavity of the design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects of the present invention;

[0022] Figure 3 A schematic diagram of the structure of the support component of the design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects of the present invention;

[0023] Figure 4 A schematic diagram of the structure of the connecting column of the design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects of the present invention;

[0024] Figure 5 A schematic diagram of the side structure of a fixing box of the design and preparation method of a 3D printed porous titanium alloy prosthesis for reconstruction of a large bone defect of the present invention;

[0025] Figure 6This is a schematic structural diagram of the enlarged point A of the design and preparation method of the 3D printed porous titanium alloy prosthesis for large bone defect reconstruction of the present invention;

[0026] Figure 7 A schematic diagram of the structure of the laying components of the design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects of the present invention;

[0027] Figure 8 A schematic diagram of the side view of the structure of the movable box of the design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects of the present invention;

[0028] In the figure: 1, fixed box; 2, printing box; 3, controller; 4, collection box; 5, filter assembly; 6, discharge pipe; 7, connecting pipe; 8, laser box; 9, sealing door; 11, cavity; 12, dust suction port; 13, fixed groove; 14, laying assembly; 15, support assembly; 16, opening; 17, support seat; 18, sealing ring; 19, movable seat; 20, bolt; 21, fixed column; 22, movable column; 23, lifting mechanism; 24, connecting column ; 25. Arc block; 26. Storage cavity; 27. Annular tube; 28. Pipeline; 29. ​​Fixed cavity; 30. Support mechanism; 31. Support plate; 32. Positioning hole; 33. Fixed block; 34. Positioning column; 35. Movable box; 36. Fixed tube; 37. Displacement mechanism; 38. Mounting hole; 39. Power mechanism; 40. Feed pipe; 41. Heating mechanism; 42. Heating block; 43. Connecting bucket; 44. Roller; 45. Scraper; 46. Driven roller. DETAILED DESCRIPTION

[0029] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0030] See also Figures 1 to 8The present invention provides a technical solution: a design and preparation method of a 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects, including a preparation method, wherein the preparation method comprises the following steps: step 1, using CT to obtain bone defect data; step 2, using CT three-dimensional bone image segmentation and modeling software developed based on mechanical principles to establish a high-precision three-dimensional model of the bone defect; step 3, using three-dimensional CAD software to parametrically design a personalized bone defect prosthesis so that it has an anatomical shape and internal porous structure that matches the bone defect, and at the same time realizes a rapid conversion of a discrete bone defect digital model to a parametric digital model; step 4, importing the model data into the metal It is a powder printer, which uses the medical spherical titanium alloy powder and printing process parameters independently developed by the team in the early stage to manufacture personalized titanium alloy substrates; Step 5, a vacuum magnetron sputtering coating system is used to conduct tantalum coating experiments, and tantalum coatings of different thicknesses are prepared by optimizing sputtering power, sputtering angle, argon gas pressure and sputtering time to ensure that the bonding is firm and does not fall off; Step 6, a mechanical testing machine is used to conduct compression mechanical tests, and the coating thickness is measured by cutting the titanium-based tantalum coating cross-section sample with a high-speed precision cutting machine, and then the metallographic observation sample is prepared, and the coating thickness is measured by observation, and the X-ray photoelectron spectroscopy is used to test the coating distribution uniformity and thickness, and the coating coverage;

[0031] The metal powder printer in step four is realized by a printing device body, which includes a fixed box 1, a printing box 2 is fixed on the top of the fixed box 1, a cavity 11 is opened inside the printing box 2, a dust suction port 12 and a fixed groove 13 are respectively opened on the inner wall of the cavity 11, a laying component 14 is movably installed inside the fixed groove 13, a collecting box 4 is fixedly installed on one side of the fixed box 1, a filter component 5 and a discharge pipe 6 are respectively fixedly installed on the sides of the collecting box 4, a connecting pipe 7 is fixed between the collecting box 4 and the printing box 2, and one end of the connecting pipe 7 is connected to the dust suction port 12.

[0032] In this embodiment, a laser box 8 is fixedly installed on the top of the printing box 2, a controller 3 is fixedly installed on the side of the printing box 2, an opening 16 is opened on the other side of the printing box 2, a sealing door 9 is movably installed on the side of the opening 16, a storage chamber 26 is opened on the inner wall of the cavity 11, a support assembly 15 is movably installed inside the storage chamber 26, the support assembly 15 includes a support seat 17, a sealing ring 18 is fixed on the side of the support seat 17, the sealing ring 18 is in contact with the inner wall of the storage chamber 26, a movable seat 19 is movably installed on the top of the support seat 17, the movable seat 19 is movably installed on the support seat 17 by bolts 20, a fixed column 21 is welded to the bottom of the support seat 17, a movable column 22 is movably installed at one end of the fixed column 21, and the sealing ring 18 blocks dust on the support seat 17, thereby effectively preventing metal powder from falling to the bottom of the storage chamber 26.

[0033] In this embodiment, a lifting mechanism 23 is installed at one end of the movable column 22. The lifting mechanism 23 is an electric push rod. The electric push rod pushes the support seat 17 to move up and down. During printing, according to the height of the prosthesis printing, the support seat 17 drives the movable seat 19 to move downward to complete the laying of the later metal powder. The lifting mechanism 23 is fixedly installed at one end of the storage cavity 26. A fixed cavity 29 is opened at one end of the movable column 22. A connecting column 24 is movably installed inside the fixed cavity 29. The connecting column 24 is welded to one end of the fixed column 21. An arc block 25 is welded on the side of the connecting column 24. A positioning hole 32 is opened on the arc block 25. A fixed block 33 is welded inside the fixed cavity 29. A positioning column 34 is welded at the bottom of the fixed block 33. One end of the positioning column 34 is movably installed inside the positioning hole 32 A support mechanism 30 is fixed inside the fixed cavity 29, and the support mechanism 30 is a support spring. The support spring pushes the support plate 31 to move upward, and the support plate 31 pushes the connecting column 24 to move upward, so that the positioning hole 32 on the arc block 25 is installed on the positioning column 34, and the connecting column 24 is limited up and down. A support plate 31 is fixed at one end of the support mechanism 30, and the support plate 31 is movably in contact with one end of the connecting column 24. An annular tube 27 is fixed on the side of the storage cavity 26, and a pipe 28 is fixed on one side of the annular tube 27. One end of the pipe 28 is fixed on the collection box 4. Later, the connecting column 24 is pressed downward, and the positioning hole 32 is separated from the positioning column 34. After separation, the connecting column 24 is driven to rotate, and the connecting column 24 rotates to separate the arc block 25 and the fixed block 33. After separation, the connecting column 24 is quickly taken out upward.

[0034] In this embodiment, the laying component 14 includes a movable box 35, and a fixed tube 36 is fixed on the side of the movable box 35. The fixed tube 36 is connected to an external feeding hose. A displacement mechanism 37 is fixedly installed on the fixed tube 36. The displacement mechanism 37 is an electric push rod. The electric push rod pushes the movable box 35 to move back and forth inside the cavity 11 to complete the laying of metal powder. The displacement mechanism 37 is fixedly installed on the printing box 2. A mounting hole 38 is opened on the side of the movable box 35. A power mechanism 39 is fixedly installed inside the mounting hole 38. The power mechanism 39 is a brushless motor. The brushless motor drives the roller 44 to rotate to complete the compaction of the metal powder. A feed pipe 40 is fixedly installed between the fixed tubes 36. The feed pipe 40 is fixedly installed inside the movable box 35. A heating mechanism 41 is fixedly installed on the side of the tube 40. The heating mechanism 41 and the heating block 42 are both composed of electric heating wires. When the electric heating wires are energized, high temperature is generated to preheat the metal powder. A connecting bucket 43 is fixed to the bottom of the feeding tube 40. A roller 44 is rotatably installed inside the movable box 35. The roller 44 is installed on the power mechanism 39. The connecting bucket 43 is installed between the rollers 44. A heating block 42 and a scraper 45 are respectively fixed on the inner wall of the movable box 35. A driven roller 46 is rotatably installed inside the movable box 35. The driven roller 46 is rotatably installed at the bottom of the roller 44. The heating block 42 is installed on the top of the roller 44. The scraper 45 is installed at the bottom of the roller 44. The scraper 45 cleans the powder adhered to the roller 44 and the driven roller 46.

[0035] The device provides the required electrical energy for the electrical appliances inside the device through an external power supply. In addition, the external control device is connected to the laser printing component to complete precise printing. Before printing, the lifting mechanism 23 is started to push the support seat 17 to move upward, and the support seat 17 is higher than the height of the inner wall of the cavity 11. The movable seat 19 is installed on the support seat 17 through the bolt 20. The lifting mechanism 23 is retracted, and the support seat 17 drives the movable seat 19 to descend. After the movable seat 19 descends, the top is flush with the height of the inner wall of the cavity 11. After flushing, the displacement mechanism 37 is started to push the movable box 35 to move inside the cavity 11. When the movable box 35 moves, the external feeding pipe The metal powder is pushed into the interior of the fixed tube 36 and the feed tube 40. Before the metal powder falls into the roller 44, the feed tube 40 is wrapped and heated by the heating mechanism 41 to achieve a preliminary temperature rise for the metal powder inside the feed tube 40. When the metal powder falls from the connecting bucket 43 between the rollers 44, the power mechanism 39 is started to drive the roller 44 to rotate. Before the roller 44 rotates, the heating block 42 heats the roller 44. The high temperature on the roller 44 is used for secondary temperature rise of the metal powder. The roller 44 is squeezed inward to achieve a preliminary compaction of the metal powder. The compacted metal powder is laid on the movable seat 19. The movement of the movable box 35 completes the secondary compaction of the metal powder through the driven roller 46. The roller 44 and the driven roller 46 rotate on the scraper 45. The rotation completes the cleaning of the powder adhering to the roller 44 and the driven roller 46 through the scraper 45. After the single layer of powder is laid, it is sintered by laser metal. After sintering, the movable box 15 is started again to lay the metal powder. As the height of the prosthesis sintering continues to increase, the lifting mechanism 23 drives the support seat 17 and the movable seat 19 to move downward, so that the metal powder is gradually laid on the top of the prosthesis to complete the sintering. After printing contact, the movable seat 19 and the support seat 17 are moved to the storage chamber 26. Internally, suction is generated by the cooperation of the external exhaust mechanism and the discharge pipe 6, and the suction is transmitted to the inside of the pipe 28 through the collecting box 4. The pipe 28 absorbs the dust on the movable seat 19 through the annular pipe 27 and collects it inside the external collecting device, so as to facilitate the reuse of the metal powder in the later stage. A large amount of dust is collected before the printed prosthesis is taken out, thereby avoiding the harm of the metal powder to the human body. When the prosthesis is taken out, the connecting column 24 is pressed downward, and the positioning hole 32 is separated from the positioning column 34. After separation, the connecting column 24 is driven to rotate. The connecting column 24 rotates to separate the arc block 25 and the fixed block 33. After separation, the connecting column 24 is quickly taken out upward.

[0036] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the attached claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention. Any figure mark in the claims should not be regarded as limiting the claims involved.

[0037] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A method for designing and preparing a 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects, characterized in that: The preparation method comprises the following steps: step 1, using CT to obtain bone defect data; step 2, using CT three-dimensional bone image segmentation and modeling software developed based on mechanical principles to establish a high-precision three-dimensional model of bone defects; step 3, using three-dimensional CAD software to parametrically design a personalized bone defect prosthesis so that it has an anatomical shape and internal porous structure that matches the bone defect, and at the same time realizes the rapid conversion of a discrete bone defect digital model to a parametric digital model; step 4, importing the model data into a metal powder printer, and using medical spherical titanium alloy powder and printing process parameters to manufacture a personalized titanium alloy substrate; step 5, using a vacuum magnetron sputtering coating system to conduct a tantalum coating experiment, and preparing tantalum coatings of different thicknesses by optimizing sputtering power, sputtering angle, argon gas pressure and sputtering time to ensure that the bonding is firm and does not fall off; step 6, using a mechanical testing machine to conduct a compression mechanical test, the coating thickness is cut by a high-speed precision cutting machine to obtain a titanium-based tantalum coating cross-section sample, and then a metallographic observation sample is prepared, and the coating thickness is measured by observation, and the X-ray photoelectron energy spectrum is used to collaboratively test the coating distribution uniformity and thickness, and the coating coverage; The metal powder printer in step 4 is implemented by a printing device body, the printing device body comprising a fixed box (1), a printing box (2) fixed on the top of the fixed box (1), a cavity (11) opened inside the printing box (2), a dust suction port (12) and a fixed groove (13) are respectively opened on the inner wall of the cavity (11), a laying component (14) is movably installed inside the fixed groove (13), a collecting box (4) is fixedly installed on one side of the fixed box (1), a filter component (5) and a discharge pipe (6) are respectively fixedly installed on the side of the collecting box (4), a connecting pipe (7) is fixed between the collecting box (4) and the printing box (2), and one end of the connecting pipe (7) is connected to the dust suction port (12).

2. The design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects according to claim 1, characterized in that: A laser box (8) is fixedly mounted on the top of the printing box (2), a controller (3) is fixedly mounted on the side of the printing box (2), an opening (16) is opened on the other side of the printing box (2), and a sealing door (9) is movably mounted on the side of the opening (16).

3. The design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects according to claim 1, characterized in that: A receiving cavity (26) is formed on the inner wall of the cavity (11), a support assembly (15) is movably mounted inside the receiving cavity (26), the support assembly (15) comprises a support seat (17), a sealing ring (18) is fixed on the side of the support seat (17), and the sealing ring (18) is in contact with the inner wall of the receiving cavity (26).

4. The design and preparation method of the 3D printed porous titanium alloy prosthesis for reconstruction of large bone defects according to claim 3 is characterized in that: A movable seat (19) is movably mounted on the top of the support seat (17), and the movable seat (19) is movably mounted on the support seat (17) by means of bolts (20). A fixed column (21) is welded to the bottom of the support seat (17), and a movable column (22) is movably mounted on one end of the fixed column (21).

5. The design and preparation method of a 3D printed porous titanium alloy prosthesis for reconstruction of a large bone defect according to claim 4, characterized in that: A lifting mechanism (23) is installed at one end of the movable column (22), and the lifting mechanism (23) is fixedly installed at one end of the storage cavity (26). A fixed cavity (29) is opened at one end of the movable column (22), and a connecting column (24) is movably installed inside the fixed cavity (29), and the connecting column (24) is welded to one end of the fixed column (21).

6. The design and preparation method of a 3D printed porous titanium alloy prosthesis for reconstruction of a large bone defect according to claim 5, characterized in that: An arc block (25) is welded to the side of the connecting column (24), a positioning hole (32) is opened on the arc block (25), a fixing block (33) is welded inside the fixing cavity (29), a positioning column (34) is welded to the bottom of the fixing block (33), and one end of the positioning column (34) is movably installed inside the positioning hole (32).

7. The method for designing and preparing a 3D printed porous titanium alloy prosthesis for reconstruction of a large bone defect according to claim 5, characterized in that: A support mechanism (30) is fixed inside the fixed cavity (29), a support plate (31) is fixed to one end of the support mechanism (30), the support plate (31) is in movably contact with one end of the connecting column (24), a ring tube (27) is fixed to the side of the storage cavity (26), a pipe (28) is fixed to one side of the ring tube (27), and one end of the pipe (28) is fixed to the collection box (4).

8. The method for designing and preparing a 3D printed porous titanium alloy prosthesis for reconstruction of a large bone defect according to claim 1, characterized in that: The laying assembly (14) comprises a movable box (35), a fixed tube (36) is fixed on the side of the movable box (35), the fixed tube (36) is connected to an external material supply hose, a displacement mechanism (37) is fixedly installed on the fixed tube (36), and the displacement mechanism (37) is fixedly installed on the printing box (2), and a mounting hole (38) is opened on the side of the movable box (35), and a power mechanism (39) is fixedly installed inside the mounting hole (38).

9. The method for designing and preparing a 3D printed porous titanium alloy prosthesis for reconstruction of a large bone defect according to claim 8, characterized in that: A feed pipe (40) is fixedly installed between the fixed pipes (36), the feed pipe (40) is fixedly installed inside the movable box (35), a heating mechanism (41) is fixedly installed on the side of the feed pipe (40), and a connecting bucket (43) is fixedly installed at the bottom of the feed pipe (40).

10. The method for designing and preparing a 3D printed porous titanium alloy prosthesis for reconstruction of a large bone defect according to claim 9, characterized in that: A roller (44) is rotatably mounted inside the movable box (35), the roller (44) is mounted on a power mechanism (39), the connecting bucket (43) is mounted between the rollers (44), a heating block (42) and a scraper (45) are respectively fixed on the inner wall of the movable box (35), a driven roller (46) is rotatably mounted inside the movable box (35), the driven roller (46) is rotatably mounted on the bottom of the roller (44), the heating block (42) is mounted on the top of the roller (44), and the scraper (45) is mounted on the bottom of the roller (44).

Images