Composition helpful for maintaining healthy level of blood sugar and preparation method thereof

Abstract

The invention discloses a composition helpful for maintaining the healthy level of blood glucose and a preparation method thereof, the composition takes NMN powder as a raw material and can improve the content level of NAD < + > in tissue cells in a state of being absorbed by a body, and based on the synergistic effect between erythritol and NMN powder meeting a proper ratio, the composition can improve the content level of NAD < + > in tissue cells. According to the composition containing the NMN powder, the effect which can be achieved by a high acceptable daily intake of a single active ingredient of the NMN powder or erythritol is generated under a relatively low dosage, so that the composition is free from toxic and side effects, and is free from pharmacological conflicts with conventional hypoglycemic drugs, so that the safety of the composition as a health food is ensured, the taste of the composition containing the NMN powder is improved, and the composition has a good application prospect. The raw material cost and the production cost of the composition are reduced, and the absorption efficiency of the body to the NMN powder in the composition is enhanced.

Description

Technical Field

[0001] The present invention relates to the technical field of functional foods, and in particular to a composition that helps maintain a healthy blood sugar level and a preparation method thereof. Background Art

[0002] Diabetes is a syndrome of a series of metabolic disorders such as protein, fat, water and electrolytes caused by the absolute or relative lack of insulin secretion and the reduced sensitivity of target tissue cells to insulin. It is characterized by hyperglycemia as the main symptom. With the changes in modern lifestyle habits, the incidence rate is increasing, and the incidence group is becoming younger. Long-term hyperglycemia can cause multi-system damage, leading to chronic progressive lesions, functional decline and even failure of tissues and organs such as eyes, kidneys, nerves, heart and blood vessels. In severe cases or under stress, it can cause acute and severe metabolic disorders. It can be said that diabetes is an important cause of cardiovascular disease, death, amputation, blindness, renal failure and heart failure. However, for the traditional diagnosis and treatment of diabetes, blood sugar levels are generally used as the diagnostic cut-off point, and whether treatment intervention is needed is determined based on the level of blood sugar levels. In other words, the traditional diagnosis and treatment of diabetes uses the level of blood sugar levels as the diagnostic standard, and intervenes in the state where the blood sugar level has been maintained at a high level. Before the blood sugar level is maintained at a high level, the function of pancreatic β cells has declined.

[0003] Early intervention in people with damaged pancreatic cells, impaired fasting blood sugar, and impaired glucose tolerance can help them get the opportunity to repair pancreatic β cells, insulin levels, cellular insulin resistance, etc., delay the onset of diabetes, and delay the onset of various complications such as cardiovascular and cerebrovascular diseases, microvascular lesions, tumors, dementia, etc. β-Nicotinamide mononucleotide (NMN) is a direct precursor of coenzyme I (nicotinamide adenine dinucleotide, NAD+), which can effectively increase the level of NAD+ in tissue cells. Almost all tissue cells in the body, including pancreatic β cells, require sufficient levels of NAD+ for the normal operation of various metabolisms. At the same time, NAD+ decreases with age, which is an important root cause of the occurrence of senile diabetes. Therefore, supplementing NMN can increase the content of NAD+ in cells, which has a positive effect on maintaining healthy blood sugar levels in healthy people and people with prediabetes and diabetes, and has been verified globally.

[0004] At present, the main way to supplement NMN is to add NMN to skin care products or health foods. For example, in the schemes disclosed in Chinese patents CN118453437A and CN117582405A, NMN is added to the aqueous phase or made into an aqueous solution and added to skin care products. However, since NMN is unstable in water and easily decomposes to form nicotinamide, resulting in a waste of NMN components, and the cost of NMN is relatively high, the cost of skin care products currently added with NMN is high, while the body's absorption rate of NMN is very low; for health foods currently containing NMN, most of them are formulated with other functional substances, which may cause the product to conflict with the medicinal properties of drugs with similar functions, thereby causing risks. Although compositions with NMN as the single functional ingredient can avoid such problems, for example, in the scheme disclosed in Chinese patent CN116251175A, the composition containing NMN components is taken in the form of capsules, but the body's absorption rate of NMN in such compositions with NMN as the single functional ingredient is slow, and it cannot be used as an emergency. Products made from NMN can be quickly absorbed after being taken as powders, but the taste of NMN raw material powder is too sour and needs to be improved by adding appropriate auxiliary materials. Since a single ingredient of NMN requires a large intake to exert its blood sugar-lowering effect, and the cost of NMN is relatively high, the selection and ratio of appropriate auxiliary ingredients are of great significance for reducing the cost of the composition, improving the safety of the composition, and synergistically enhancing the body's absorption efficiency of NMN. Summary of the invention

[0005] An object of the present invention is to provide a composition that helps maintain healthy blood sugar levels and a preparation method thereof, wherein the components of the composition have no toxic side effects and will not produce pharmacological conflicts with conventional hypoglycemic drugs, thereby helping to ensure the safety and legality of the composition as a health food.

[0006] Another object of the present invention is to provide a composition that helps maintain healthy blood sugar levels and a preparation method thereof, wherein the composition uses NMN powder as a raw material and is capable of increasing the level of NAD+ in tissue cells when absorbed by the body, thereby helping to maintain healthy blood sugar levels in healthy people and those with prediabetes or diabetes based on the root cause of diabetes.

[0007] Another object of the present invention is to provide a composition that helps maintain a healthy blood sugar level and a preparation method thereof, wherein the composition uses erythritol, microcrystalline cellulose and silicon dioxide as excipients, and thus has no toxic side effects and will not produce pharmacological conflicts with conventional hypoglycemic drugs. In this way, while ensuring the safety of the composition as a health food, the taste of the composition containing NMN powder is improved based on the synergistic effect between the components in appropriate proportions, the raw material cost and production cost of the composition are reduced, and the body's absorption efficiency of the NMN powder in the composition is enhanced.

[0008] Another object of the present invention is to provide a composition that helps maintain healthy blood sugar levels and a preparation method thereof, wherein based on the synergistic effect between the components in appropriate proportions, the composition is in powder form and has good oral suitability and fluidity, and can enhance the body's absorption efficiency of the NMN powder in the composition, thereby being able to provide timely and effective intervention for the body's blood sugar level in an oral manner.

[0009] Another object of the present invention is to provide a composition that helps maintain healthy blood sugar levels and a preparation method thereof, wherein based on the synergistic effect between erythritol and NMN powder in a suitable ratio, the composition can produce the effect that can only be achieved by a single active ingredient of NMN powder or erythritol at a high intake at a lower dosage, thereby reducing the dosage requirement of NMN powder and reducing the raw material cost of the composition.

[0010] Another object of the present invention is to provide a composition that helps maintain healthy blood sugar levels and a preparation method thereof, wherein the addition of erythritol in a suitable proportion can not only improve the taste of the composition containing NMN powder, but also play a positive role in reducing vascular damage caused by hyperglycemia based on the antioxidant properties of erythritol.

[0011] Another object of the present invention is to provide a composition that helps maintain a healthy level of blood sugar and a preparation method thereof, wherein the addition of microcrystalline cellulose in a suitable ratio can reduce the high viscosity of the composition caused by the addition of erythritol, thereby preventing the composition in powder form from agglomerating, which is beneficial to ensuring the oral suitability and fluidity of the composition. Based on the fact that microcrystalline cellulose is not absorbed by the body, does not provide calories, and can increase intestinal peristalsis, the insoluble dietary fiber properties, while ensuring the safety and low-calorie characteristics of the composition as a health food, further synergistically enhance the body's absorption efficiency of the NMN powder in the composition.

[0012] Another object of the present invention is to provide a composition that helps maintain healthy blood sugar levels and a method for preparing the same, wherein the addition of silicon dioxide in a suitable proportion can reduce the angle of repose of the composition in powder form, thereby helping to synergize with microcrystalline cellulose to improve the fluidity and uniformity of the composition during production and packaging, while facilitating production and reducing production costs, and ensuring the fluidity and consistency of the composition in the form of a health food product.

[0013] According to one aspect of the present invention, the present invention provides a composition that helps maintain healthy blood sugar levels, wherein the composition comprises 7.5-15 parts of NMN powder and 62-75 parts of erythritol by weight.

[0014] In one embodiment, the NMN powder is a powder having an NMN weight content greater than 98%.

[0015] In one embodiment, the NMN powder is a powder that passes through at least a 40-mesh sieve, and the erythritol and microcrystalline cellulose are powders that pass through at least a 60-mesh sieve.

[0016] In one embodiment, the composition further comprises 9-22 parts by weight of a lubricant and 0.5-1.5 parts of silicon dioxide, wherein the lubricant is selected from at least one of microcrystalline cellulose, talc and polyethylene glycol.

[0017] In one embodiment, the lubricant is microcrystalline cellulose.

[0018] In one embodiment, the weight portion of NMN powder is 15 parts, the weight portion of erythritol is 73.5 parts, the weight portion of microcrystalline cellulose is 10 parts, and the weight portion of silicon dioxide is 1.5 parts.

[0019] According to another aspect of the present invention, the present invention also provides a method for preparing a composition that helps maintain a healthy blood sugar level, the preparation method comprising the following steps:

[0020] (S1) mixing 7.5-15 parts of NMN powder, 62-75 parts of erythritol and 9-22 parts of microcrystalline cellulose by weight to prepare a premixed powder;

[0021] (S2) adding 0.5-1.5 parts of silicon dioxide to the premixed powder and mixing them to form a total mixed powder; and

[0022] (S3) Packaging the total mixed powder.

[0023] In one embodiment, in step (S1), the NMN powder is a powder having an NMN weight content greater than 98%.

[0024] In one embodiment, in step (S1), NMN powder is powder that passes through at least a 40-mesh sieve, and erythritol and microcrystalline cellulose are powder that pass through at least a 60-mesh sieve.

[0025] In one embodiment, in step (S1), the weight proportion of NMN powder is 15 parts, the weight proportion of erythritol is 73.5 parts, and the weight proportion of microcrystalline cellulose is 10 parts.

[0026] In one embodiment, in step (S2), the weight percentage of silicon dioxide is 1.5 parts.

[0027] Further objects and advantages of the present invention will be fully apparent through understanding of the following description. DETAILED DESCRIPTION

[0028] The following description is used to disclose the present invention so that those skilled in the art can implement the present invention. The preferred embodiments described below are only examples, and those skilled in the art can think of other obvious variations. The basic principles of the present invention defined in the following description can be applied to other embodiments, variations, improvements, equivalents, and other technical solutions that do not deviate from the spirit and scope of the present invention.

[0029] The present invention provides a composition that helps maintain a healthy blood sugar level and a preparation method thereof, wherein the components of the composition have no toxic side effects and will not produce pharmacological conflicts with conventional hypoglycemic drugs, thereby helping to ensure the safety and legality of the composition as a health food.

[0030] Specifically, the composition uses NMN powder as a raw material and can increase the NAD+ content level of tissue cells when absorbed by the body, thereby promoting energy metabolism including sugar metabolism, improving mitochondrial function, and promoting insulin secretion, as well as ensuring that deacetylases (Sirtuins) function effectively, thereby having a positive effect on the aging and apoptosis of pancreatic β cells and insulin sensitivity. Therefore, it is beneficial to maintain the healthy blood sugar level of healthy people and pre-diabetic and diabetic people from the root cause of diabetes.

[0031] Furthermore, based on the synergistic effect between erythritol and NMN powder in a suitable ratio, the composition can produce the effect that can only be achieved by a single active ingredient of NMN powder or erythritol at a high intake at a lower dosage, thereby reducing the dosage requirement of NMN powder and reducing the raw material cost of the composition.

[0032] It is worth mentioning that erythritol, as a natural sweetener with low energy and good taste, has a flavor correction effect, good dispersibility, fast dissolution in water, and no other unpleasant taste, so that the powder has a moderate sweet and sour taste and an acceptable taste; at the same time, erythritol has an endothermic effect when dissolved in water, and has a cool feeling when eaten; in addition, erythritol also plays a filling role in the composition of the present invention, which is conducive to stable production. On the other hand, erythritol can maintain the blood sugar and blood lipid homeostasis of patients with type 2 diabetes and impaired glucose tolerance, reduce fasting blood sugar and glycosylated hemoglobin, and erythritol can also inhibit the hemolysis caused by 2,20-azo-2-aminopropane dihydrochloride, and play a positive role in reducing vascular damage caused by hyperglycemia. Therefore, the addition of erythritol that meets the appropriate ratio can also improve the taste of the composition containing NMN powder, and at the same time, based on the antioxidant properties of erythritol, it plays a positive role in reducing vascular damage caused by hyperglycemia.

[0033] In detail, in the composition of the present invention, the composition comprises 7.5-15 parts of β-nicotinamide mononucleotide (NMN) powder and 62-75 parts of erythritol by weight, so as to improve the taste of the composition containing NMN powder based on the synergistic effect between erythritol and NMN powder that meet the above ratio, reduce the raw material cost and production cost of the composition, and enhance the body's absorption efficiency of the NMN powder in the composition.

[0034] Preferably, the composition further uses silicon dioxide and a lubricant as auxiliary materials, so that it has no toxic side effects and will not produce pharmacological conflicts with conventional hypoglycemic drugs. In this way, while ensuring the safety of the composition as a health food, the synergistic effect between the components in appropriate proportions can further reduce the raw material cost and production cost of the composition, and enhance the body's absorption efficiency of the NMN powder in the composition.

[0035] Specifically, in the state where the composition further uses silicon dioxide and a lubricant as auxiliary materials, the lubricant is selected from at least one of microcrystalline cellulose, talcum powder and polyethylene glycol, wherein the composition comprises 7.5-15 parts of β-nicotinamide mononucleotide (NMN) powder, 62-75 parts of erythritol, 9-22 parts of lubricants and 0.5-1.5 parts of silicon dioxide by weight. Based on the synergistic effect between the components that meet the above ratio, the composition is in the form of a powder and has good oral suitability and fluidity, and can enhance the body's absorption efficiency of the NMN powder in the composition, thereby being able to provide timely and effective intervention for the body's blood sugar level in an oral manner.

[0036] As mentioned above, based on the synergistic effect between erythritol and NMN powder that satisfy the above-mentioned ratio, the composition can produce the effect that can only be achieved by a single active ingredient of NMN powder or erythritol at a high intake at a lower dosage, thereby reducing the dosage requirement of NMN powder and reducing the raw material cost of the composition.

[0037] For example, in one embodiment of the present invention, the composition comprises 15 parts of β-nicotinamide mononucleotide (NMN) powder, 73.5 parts of erythritol, 10 parts of microcrystalline cellulose and 1.5 parts of silicon dioxide by weight. Correspondingly, after the composition of the above embodiment is packaged at a standard of 2g / bag, each bag of the mixture contains 300mgNMN powder. Self-control and inter-group control methods were used to select voluntary subjects who met the experimental conditions to take NMN (300mg / day), NMN (600mg / day), and the composition of the above embodiment (1 bag / day) for 60 days, during which dietary control was maintained, and the original type and dosage of diabetes treatment drugs remained unchanged. The results show that:

[0038] (1) There was no significant difference in fasting blood glucose and 2-hour postprandial blood glucose between the subjects taking NMN (300 mg / day) and themselves before and after the trial or between the subjects taking NMN and the control group after the trial (P>0.05).

[0039] (2) Taking NMN (600 mg / day) has an improving effect on the main clinical symptoms of diabetes. The total improvement rate is significantly different from that of the control group (P<0.05). There are significant differences in the fasting blood glucose of the trial group before and after the trial and compared with the control group after the trial (P<0.05). There are significant differences in the 2-hour postprandial blood glucose of the trial group before and after the trial and compared with the control group after the trial (P<0.05). There are significant differences in the reduction of fasting blood glucose and 2-hour postprandial blood glucose and the effective rate of reduction in the trial group compared with the control group (P<0.05). The fasting blood glucose of the trial group decreased by 11.70% after the trial compared with that before the trial, and the 2-hour postprandial blood glucose decreased by 11.52% after the trial compared with that before the trial.

[0040] (3) The composition of the above embodiment has an improving effect on the main clinical symptoms of diabetes. The total improvement rate is significantly different from that of the control group (P<0.05). The fasting blood glucose of the trial group before and after the trial and compared with the control group after the trial are significantly different (P<0.05). The blood glucose 2 hours after the meal of the trial group before and after the trial and compared with the control group after the trial are significantly different (P<0.05). The reduction range of fasting blood glucose and 2 hours after the meal and the reduction efficiency of the trial group are significantly different from those of the control group (P<0.05). The fasting blood glucose of the trial group after the trial decreased by 11.58% compared with that before the trial, and the blood glucose 2 hours after the meal decreased by 11.04% compared with that before the trial.

[0041] According to the evaluation standard of "Assisted hypoglycemic function evaluation method" (National Food and Drug Administration

[2012] No. 107), it is suggested that the composition of the above embodiment has the function of assisting hypoglycemic function. After the trial, there were no obvious abnormal changes in body weight, blood pressure, and heart rate. The blood routine, urine routine (except urine sugar), stool routine and biochemical index tests were all within the normal range. No obvious adverse reactions were found during the trial.

[0042] It is worth mentioning that the addition of microcrystalline cellulose that meets the above-mentioned ratio can reduce the high viscosity of the composition caused by the addition of erythritol, thereby preventing the composition in powder form from agglomerating, which is beneficial to ensuring the oral suitability and fluidity of the composition. Microcrystalline cellulose is not absorbed by the body, does not provide calories, and has the properties of an insoluble dietary fiber that increases intestinal peristalsis. While ensuring the safety and low-calorie characteristics of the composition as a health food, it further synergistically enhances the body's absorption efficiency of the NMN powder in the composition.

[0043] In addition, the addition of silicon dioxide that satisfies the above-mentioned ratio can reduce the angle of repose of the composition in powder form, which is beneficial for synergizing with microcrystalline cellulose to improve the fluidity and uniformity of the composition during production and packaging, while facilitating production and reducing production costs, and ensuring the fluidity and consistency of the composition in the form of a health food product.

[0044] To further disclose the present invention, taking microcrystalline cellulose as an example of the lubricant in the composition, the present invention also provides a method for preparing the composition, which comprises the following steps:

[0045] (S1) mixing 7.5-15 parts of β-nicotinamide mononucleotide (NMN) powder, 62-75 parts of erythritol and 9-22 parts of microcrystalline cellulose by weight to prepare a premixed powder;

[0046] (S2) adding 0.5-1.5 parts of silicon dioxide to the premixed powder and mixing them to form a total mixed powder; and

[0047] (S3) Packaging the total mixed powder.

[0048] Preferably, in step (S1), the NMN powder is a powder having an NMN weight content greater than 98%.

[0049] Furthermore, in step (S1), the NMN powder is a powder that passes through at least a 40-mesh sieve, and the erythritol and microcrystalline cellulose are powders that pass through at least a 60-mesh sieve.

[0050] In one embodiment, in step (S1), the weight proportion of NMN powder is 15 parts, the weight proportion of erythritol is 73.5 parts, and the weight proportion of microcrystalline cellulose is 10 parts.

[0051] Furthermore, in the above embodiment, in step (S2), the weight portion of silicon dioxide is 1.5 parts.

[0052] Those skilled in the art will appreciate that the above embodiments are merely examples, and features of different embodiments may be combined with each other to obtain implementation methods that are easily conceivable but not explicitly stated based on the contents disclosed in the present invention.

[0053] It should be understood by those skilled in the art that the embodiments of the present invention described above are only examples and do not limit the present invention. The purpose of the present invention has been fully and effectively achieved. The functional and structural principles of the present invention have been demonstrated and explained in the embodiments, and the embodiments of the present invention may be deformed or modified in any way without departing from the principles.

Claims

1. A composition that helps maintain healthy blood sugar levels, characterized in that: The invention comprises 7.5-15 parts of NMN powder and 62-75 parts of erythritol by weight.

2. The composition that helps maintain healthy blood sugar levels according to claim 1, wherein the NMN powder is a powder with an NMN weight content greater than 98%.

3. The composition according to claim 2 that helps maintain healthy blood sugar levels, wherein the NMN powder is a powder that passes through at least a 40-mesh sieve, and the erythritol and microcrystalline cellulose are powders that pass through at least a 60-mesh sieve.

4. The composition according to any one of claims 1 to 3 that helps maintain healthy blood sugar levels, wherein the composition further comprises 9-22 parts by weight of a lubricant and 0.5-1.5 parts of silicon dioxide, wherein the lubricant is selected from at least one of microcrystalline cellulose, talc and polyethylene glycol.

5. The composition for maintaining healthy blood sugar level according to claim 4, wherein the lubricant is microcrystalline cellulose.

6. The composition according to claim 5 that helps maintain healthy blood sugar levels, wherein the weight portion of NMN powder is 15 parts, the weight portion of erythritol is 73.5 parts, the weight portion of microcrystalline cellulose is 10 parts, and the weight portion of silicon dioxide is 1.5 parts.

7. A method for preparing a composition that helps maintain healthy blood sugar levels, characterized in that: The following steps are involved: (S1) mixing 7.5-15 parts of NMN powder, 62-75 parts of erythritol and 9-22 parts of microcrystalline cellulose by weight to prepare a premixed powder; (S2) adding 0.5-1.5 parts of silicon dioxide to the premixed powder and mixing them to form a total mixed powder; and (S3) Packaging the total mixed powder.

8. The method for preparing a composition that helps maintain healthy blood sugar levels according to claim 7, wherein in step (S1), the NMN powder is a powder having an NMN weight content greater than 98%.

9. The method for preparing a composition that helps maintain healthy blood sugar levels according to claim 8, wherein in step (S1), the NMN powder is a powder that passes through at least a 40-mesh sieve, and the erythritol and microcrystalline cellulose are powders that pass through at least a 60-mesh sieve.

10. A method for preparing a composition that helps maintain healthy blood sugar levels according to any one of claims 7 to 9, wherein in step (S1), the weight parts of NMN powder are 15 parts, the weight parts of erythritol are 73.5 parts, and the weight parts of microcrystalline cellulose are 10 parts.

11. The method for preparing a composition that helps maintain healthy blood sugar levels according to claim 10, wherein in step (S2), the weight portion of silicon dioxide is 1.5 parts.