Bacteriostatic shampoo for preventing infection and preparation method thereof

Abstract

The invention provides antibacterial shampoo for preventing infection and a preparation method thereof.The antibacterial shampoo is composed of 5-10 wt% of active ingredient composition and 90-95 wt% of auxiliary materials, the active ingredient composition comprises a component A and a component B with the mass ratio being 2-4: 1, and the component A comprises 2-4 parts of agilawood micro-emulsion, 2-4 parts of morinda citrifolia fruit micro-emulsion, 1-3 parts of ganoderma lucidum fermentation liquor and 1-3 parts of biological peptide; the component B is prepared from 1 to 3 parts of saponin extract, 1 to 3 parts of cacumen biotae extract, 1 to 3 parts of radix polygoni multiflori extract, 1 to 3 parts of radix ginseng extract, 0.8 to 1.2 parts of herba houttuyniae extract, 2 to 4 parts of radix sophorae flavescentis extract, 2 to 4 parts of fructus viticis extract and 0.8 to 1.2 parts of herba ecliptae extract; the auxiliary materials comprise the following components in parts by weight: 4-6 parts of chitosan / cationic guar gum composite gel, 0.2-0.4 part of a thickening agent, 1-3 parts of a surfactant and 500-600 parts of water. According to the shampoo disclosed by the invention, the active components are compounded, so that efficient and mild bacteriostasis is realized, infection after hair transplantation is prevented, wounds can be quickly repaired, scalp can be protected, and the shampoo is safe and non-irritant and has popularization value.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemical products, and in particular to an antibacterial shampoo for preventing infection and a preparation method thereof. Background Art

[0002] Shampoo, also known as shampoo, shampoo, essence or shampoo cream, is the most widely used hair care product and one of the most commonly used hair cosmetics. It is used to wash away the oil secreted by the human body, sweat, cells shed from the scalp, foreign dust, microorganisms, residues of styling products and bad odors attached to the scalp and hair, keeping the scalp and hair clean and beautiful.

[0003] With the pursuit of beauty by modern people, hair transplantation has become common. During the recovery period after hair transplantation, special attention should be paid to the protection of the transplantation area. Generally speaking, hair and scalp cleaning can be performed one week after hair transplantation. In the early stage after hair transplantation, there may be blood scabs, exudates or other dirt on the scalp. At the same time, the scalp will have a certain degree of swelling, redness or slight inflammation after surgery. If it is not cleaned properly, it will irritate the scalp and cause postoperative infection. At the same time, ordinary antiseptic shampoos currently do not have a sterilization function, so they cannot completely kill pathogenic microorganisms, which may pose a threat to our health.

[0004] Therefore, it is of practical significance to develop a shampoo that can not only effectively inhibit bacteria and prevent infection, but also quickly repair wounds, protect the scalp, and is safe and non-irritating. Summary of the invention

[0005] In view of this, the present invention proposes an antibacterial shampoo for preventing infection and a preparation method thereof to solve the above technical problems.

[0006] The technical solution of the present invention is achieved in this way:

[0007] An antibacterial shampoo for preventing infection, comprising 5-10 wt% of an active ingredient composition and 90-95 wt% of an auxiliary material;

[0008] The active ingredient composition comprises component A and component B in a mass ratio of 2-4:1;

[0009] The component A comprises the following raw materials in parts by weight: 2-4 parts of agarwood microemulsion, 2-4 parts of Morinda citrifolia microemulsion, 1-3 parts of ganoderma lucidum fermentation liquid, and 1-3 parts of biological peptide;

[0010] The component B comprises the following raw materials in parts by weight: 1-3 parts of Gleditsia sinensis extract, 1-3 parts of Platycladus orientalis leaf extract, 1-3 parts of Polygonum multiflorum extract, 1-3 parts of Ginseng extract, 0.8-1.2 parts of Houttuynia cordata extract, 2-4 parts of Sophora flavescens extract, 2-4 parts of Vitex rotundifolia extract, and 0.8-1.2 parts of Eclipta prostrata extract;

[0011] The auxiliary materials include the following raw materials in parts by weight: 4-6 parts of chitosan / cationic guar gum composite gel, 0.2-0.4 parts of thickener, 1-3 parts of surfactant, and 500-600 parts of water.

[0012] Furthermore, the preparation method of the agarwood microemulsion is as follows: fresh agarwood leaves are crushed and added into water, and steam distilled to obtain agarwood essential oil, the agarwood essential oil and the active agent are evenly mixed, deionized water is added and vortexed at the same time, and ultrasonic treatment is performed to obtain the agarwood microemulsion;

[0013] The preparation method of the Morinda citrifolia microemulsion comprises the following steps: pulping and crushing fresh Morinda citrifolia, adding the pulp into water, performing steam distillation to obtain Morinda citrifolia essential oil, uniformly mixing the Morinda citrifolia essential oil and Tween 60, adding deionized water and performing vortex oscillation at the same time, and performing ultrasonic treatment to obtain the Morinda citrifolia microemulsion.

[0014] Further, in the preparation method of agarwood microemulsion, the solid-liquid ratio of the agarwood leaves to water is 1:6-10g / mL; the temperature of the steam distillation is 180-200°C, and the time is 4-6h; the active agent is Tween 20 and Span 20 in a mass ratio of 1:1-3; the mass ratio of the agarwood essential oil to the active agent is 1:3-5; the volume ratio of the deionized water to the agarwood essential oil is 3-5:1; the speed of the vortex oscillation is 1000-2000rpm, and the time is 1-3min; the time of the ultrasonic treatment is 3-5min, and the rotation speed is 200-300rpm;

[0015] In the preparation method of Morinda citrifolia microemulsion, the solid-liquid ratio of Morinda citrifolia to water is 1:10-15g / mL; the temperature of the steam distillation is 180-200°C, and the time is 4-6h; the mass ratio of the Morinda citrifolia essential oil to Tween 60 is 1:2-4; the volume ratio of the deionized water to the Morinda citrifolia essential oil is 3-5:1; the speed of the vortex oscillation is 1000-2000rpm, and the time is 1-3min; the time of the ultrasonic treatment is 3-5min, and the rotation speed is 200-300rpm.

[0016] Furthermore, the biological peptide is composed of β-casein phosphopeptide and β-antimicrobial peptide in a mass ratio of 1:1-2.

[0017] Furthermore, the preparation method of each plant extract of component B is: crushing sapodilla, Platycladus orientalis leaf, Polygonum multiflorum, ginseng, Houttuynia cordata, Sophora flavescens, Vitex rotundifolia and Eclipta prostrata, and extracting them respectively through a supercritical CO2 fluid extractor to obtain sapodilla extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, ginseng extract, Houttuynia cordata extract, Sophora flavescens extract, Vitex rotundifolia extract and Eclipta prostrata extract.

[0018] Furthermore, the supercritical CO2 fluid extraction has a pressure of 20-30 MPa, a temperature of 40-60°C, and a time of 30-60 min.

[0019] Furthermore, the preparation method of the chitosan / cationic guar gum composite gel is: mixing 0.5%-2.0% w / v chitosan solution and 0.5%-2.0% w / v cationic guar gum solution in a volume ratio of 1-3:1, ultrasonically stirring, and adjusting the pH to 4.5-6.0.

[0020] Furthermore, the thickener is an amino acid thickener PEG-120; the surfactant is sodium lauroyl glutamate and cocamidopropyl betaine in a mass ratio of 1:1-2.

[0021] A method for preparing an antibacterial shampoo for preventing infection, the specific steps comprising:

[0022] (1) Preparation of component A: Mix the agarwood microemulsion and the Morinda citrifolia microemulsion, vortex, add the Ganoderma lucidum fermentation liquid to obtain a mixed solution, then add the biopeptide, and perform ultrasonic treatment to obtain component A;

[0023] (2) ultrafinely grinding each plant extract in component B into a particle size of 1-5 μm, and mixing them evenly to obtain component B;

[0024] (3) Component A and component B are mixed, added into water with a formula amount of 40-50 wt%, mixed and stirred, chitosan / cationic guar gum composite gel is added, stirring is continued, thickener, surfactant and balance water are added, and stirred evenly to obtain the target shampoo.

[0025] Furthermore, in step (1), the ultrasonic treatment is carried out at 40-60°C and 300-400W for 40-60min; in step (3), the mixing and stirring speed is 600-800rpm, the temperature is 25-35°C, and the time is 20-30min; and the stirring time is continued for 30-40min.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] 1. The shampoo of the present invention achieves efficient and mild antibacterial effect by compounding various active components and active ingredients, prevents infection after hair transplantation, and can also quickly repair wounds and protect the scalp. It is safe and non-irritating, and has promotion value.

[0028] 2. The chitosan / cationic guar gum hydrogel of the present invention is loaded with active components A and B, and has both antibacterial and repairing effects on the scalp, thereby repairing wounds, mildly inhibiting bacteria, and preventing postoperative infection. At the same time, it can also form a protective layer on the scalp to resist external stimuli, further prevent wound infection, and can also be used as a softening conditioner to enhance the consumer's experience of use. DETAILED DESCRIPTION

[0029] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0030] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0031] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0032] According to actual conditions, the shampoo of the present invention also includes a preservative and a transdermal agent (aqueous azone), and the added amounts all meet the standards.

[0033] The thickener of the present invention is an amino acid thickener PEG-120; the surfactant of the present invention is sodium lauroyl glutamate and cocamidopropyl betaine in a mass ratio of 1:1-2.

[0034] Example 1

[0035] The antibacterial shampoo for preventing infection in this embodiment is composed of 8 wt% of the active ingredient composition and 92 wt% of the auxiliary materials; the active ingredient composition includes component A and component B in a mass ratio of 3:1;

[0036] Component A comprises the following raw materials in parts by weight: 3 parts of agarwood microemulsion, 3 parts of Morinda citrifolia microemulsion, 2 parts of ganoderma lucidum fermentation liquid, and 2 parts of biological peptides (β-casein phosphopeptide and β-antimicrobial peptide in a mass ratio of 1:1.5);

[0037] The preparation method of the agarwood microemulsion is as follows: fresh agarwood leaves are crushed, and the agarwood leaves are added to water according to a solid-liquid ratio of 1:8 g / mL, and steam distilled at 190°C for 5 hours to obtain agarwood essential oil, and the agarwood essential oil and an active agent with a mass ratio of 1:4 are evenly mixed, and the active agent is Tween 20 and Span 20 with a mass ratio of 1:2, and deionized water is added, and the volume ratio of deionized water to agarwood essential oil is 4:1, and vortex oscillation (1500rpm) is performed at the same time for 2 minutes, and ultrasonic treatment is performed at 250rpm for 4 minutes after completion to obtain agarwood microemulsion;

[0038] The preparation method of Morinda citrifolia microemulsion is as follows: fresh Morinda citrifolia is pulped and crushed, the Morinda citrifolia is added into water at a solid-liquid ratio of 1:13 g / mL, and steam distilled at 190°C for 5 hours to obtain Morinda citrifolia essential oil, the Morinda citrifolia essential oil and Tween 60 at a mass ratio of 1:3 are uniformly mixed, deionized water is added, the volume ratio of deionized water to Morinda citrifolia essential oil is 4:1, and vortex oscillation (1500 rpm) is performed simultaneously for 2 minutes, and ultrasonic treatment is performed at 250 rpm for 4 minutes to obtain Morinda citrifolia microemulsion.

[0039] Component B comprises the following raw materials in parts by weight: 2 parts of Gleditsia sinensis extract, 2 parts of Platycladus orientalis leaf extract, 2 parts of Polygonum multiflorum extract, 2 parts of Ginseng extract, 1 part of Houttuynia cordata extract, 3 parts of Sophora flavescens extract, 3 parts of Vitex rotundifolia extract, and 1 part of Eclipta prostrata extract;

[0040] The preparation method of each extract is as follows: Gleditsia sinensis, Platycladus orientalis leaf, Polygonum multiflorum, ginseng, Houttuynia cordata, Sophora flavescens, Vitex rotundifolia and Eclipta prostrata are crushed, and then supercritical CO2 fluid extraction is performed at 25 MPa and 50°C for 45 minutes to obtain Gleditsia sinensis extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, ginseng extract, Houttuynia cordata extract, Sophora flavescens extract, Vitex rotundifolia extract and Eclipta prostrata extract, respectively.

[0041] The auxiliary materials include the following raw materials in parts by weight: 5 parts of chitosan / cationic guar gum composite gel, 0.3 parts of thickener, 2 parts of surfactant, and 550 parts of water.

[0042] The preparation method of the chitosan / cationic guar gum composite gel is as follows: 1.0% w / v chitosan solution and 1.0% w / v cationic guar gum solution are mixed in a volume ratio of 2:1, ultrasonically stirred, and adjusted to pH 5.5±0.5.

[0043] The preparation method of the above-mentioned antibacterial shampoo for preventing infection comprises the following specific steps:

[0044] (1) Preparation of component A: Agarwood microemulsion and Morinda citrifolia microemulsion were mixed, vortexed for 30 seconds, and Ganoderma lucidum fermentation liquid was added to obtain a mixed solution, followed by adding biopeptide, and ultrasonically treated at 50°C and 350W for 50 minutes to obtain component A;

[0045] (2) ultrafinely grinding each plant extract in component B into a particle size of 3±2 μm, and mixing them evenly to obtain component B;

[0046] (3) Component A and component B are mixed, added into 45 wt% water, stirred at 700 rpm and 30° C. for 25 min, chitosan / cationic guar gum composite gel is added, stirring is continued for 35 min, thickener, surfactant and balance water are added, stirred evenly, and the target shampoo is obtained.

[0047] Example 2

[0048] The antibacterial shampoo for preventing infection in this embodiment is composed of 10wt% of the active ingredient composition and 90wt% of the auxiliary materials; the active ingredient composition includes component A and component B in a mass ratio of 2:1;

[0049] Component A comprises the following raw materials in parts by weight: 2 parts of agarwood microemulsion, 2 parts of Morinda citrifolia microemulsion, 1 part of ganoderma lucidum fermentation liquid, and 1 part of biological peptide (β-casein phosphopeptide and β-antimicrobial peptide in a mass ratio of 1:1);

[0050] The preparation method of the agarwood microemulsion is as follows: fresh agarwood leaves are crushed, and the agarwood leaves are added to water according to a solid-liquid ratio of 1:6 g / mL, and steam distilled at 180°C for 4 hours to obtain agarwood essential oil, and the agarwood essential oil and an active agent with a mass ratio of 1:3 are evenly mixed, and the active agent is Tween 20 and Span 20 with a mass ratio of 1:1, and deionized water is added, and the volume ratio of deionized water to agarwood essential oil is 3:1, and vortex oscillation (1000 rpm) is performed for 1 minute at the same time, and ultrasonic treatment is performed at 200 rpm for 3 minutes after completion to obtain agarwood microemulsion;

[0051] The preparation method of Morinda citrifolia microemulsion is as follows: fresh Morinda citrifolia is pulped and crushed, the Morinda citrifolia is added into water at a solid-liquid ratio of 1:10 g / mL, and steam distilled at 180°C for 4 hours to obtain Morinda citrifolia essential oil, the Morinda citrifolia essential oil and Tween 60 at a mass ratio of 1:2 are uniformly mixed, deionized water is added, the volume ratio of deionized water to Morinda citrifolia essential oil is 3:1, and vortex oscillation (1000 rpm) is performed simultaneously for 1 minute, and ultrasonic treatment is performed at 200 rpm for 3 minutes to obtain Morinda citrifolia microemulsion.

[0052] Component B comprises the following raw materials in parts by weight: 1 part of Gleditsia sinensis extract, 1 part of Platycladus orientalis leaf extract, 1 part of Polygonum multiflorum extract, 1 part of Ginseng extract, 0.8 part of Houttuynia cordata extract, 2 parts of Sophora flavescens extract, 2 parts of Vitex rotundifolia extract, and 0.8 part of Eclipta prostrata extract;

[0053] The preparation method of each extract is as follows: Gleditsia sinensis, Platycladus orientalis leaf, Polygonum multiflorum, ginseng, Houttuynia cordata, Sophora flavescens, Vitex rotundifolia and Eclipta prostrata are crushed, and then supercritical CO2 fluid extraction is performed at 20 MPa and 40°C for 30 minutes to obtain Gleditsia sinensis extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, ginseng extract, Houttuynia cordata extract, Sophora flavescens extract, Vitex rotundifolia extract and Eclipta prostrata extract, respectively.

[0054] The auxiliary materials include the following raw materials in parts by weight: 4 parts of chitosan / cationic guar gum composite gel, 0.2 parts of thickener, 1 part of surfactant, and 500 parts of water.

[0055] The preparation method of the chitosan / cationic guar gum composite gel is as follows: 0.5% w / v chitosan solution and 0.5% w / v cationic guar gum solution are mixed in a volume ratio of 1:1, ultrasonically stirred, and adjusted to pH 5.5±0.5.

[0056] The preparation method of the above-mentioned antibacterial shampoo for preventing infection comprises the following specific steps:

[0057] (1) Preparation of component A: Agarwood microemulsion and Morinda citrifolia microemulsion were mixed, vortexed for 30 seconds, and Ganoderma lucidum fermentation liquid was added to obtain a mixed solution, followed by adding biopeptide, and ultrasonically treated at 40°C and 300W for 40 minutes to obtain component A;

[0058] (2) ultrafinely grinding each plant extract in component B into a particle size of 3±2 μm, and mixing them evenly to obtain component B;

[0059] (3) Component A and component B are mixed, added into 40 wt% water, 600 pm, and stirred at 25° C. for 20 min, chitosan / cationic guar gum composite gel is added, stirring is continued for 30 min, thickener, surfactant and balance water are added, and stirred evenly to obtain the target shampoo.

[0060] Example 3

[0061] The antibacterial shampoo for preventing infection in this embodiment is composed of 10wt% of the active ingredient composition and 90wt% of the auxiliary materials; the active ingredient composition includes component A and component B in a mass ratio of 4:1;

[0062] Component A comprises the following raw materials in parts by weight: 4 parts of agarwood microemulsion, 4 parts of Morinda citrifolia microemulsion, 3 parts of ganoderma lucidum fermentation liquid, and 3 parts of biological peptides (β-casein phosphopeptide and β-antimicrobial peptide in a mass ratio of 1:2);

[0063] The preparation method of the agarwood microemulsion is as follows: fresh agarwood leaves are crushed, and the agarwood leaves are added to water according to a solid-liquid ratio of 1:10 g / mL, and steam distilled at 200°C for 6 hours to obtain agarwood essential oil, and the agarwood essential oil and an active agent with a mass ratio of 1:5 are evenly mixed, and the active agent is Tween 20 and Span 20 with a mass ratio of 1:3, and deionized water is added, and the volume ratio of deionized water to agarwood essential oil is 5:1, and vortex oscillation (2000 rpm) is performed for 3 minutes at the same time, and ultrasonic treatment is performed at 300 rpm for 5 minutes after completion to obtain agarwood microemulsion;

[0064] The preparation method of Morinda citrifolia microemulsion is as follows: fresh Morinda citrifolia is pulped and crushed, the Morinda citrifolia is added into water at a solid-liquid ratio of 1:15 g / mL, and steam distilled at 200°C for 6 hours to obtain Morinda citrifolia essential oil, the Morinda citrifolia essential oil and Tween 60 at a mass ratio of 1:4 are uniformly mixed, deionized water is added, the volume ratio of deionized water to Morinda citrifolia essential oil is 5:1, and vortex oscillation (2000 rpm) is performed simultaneously for 3 minutes, and ultrasonic treatment is performed at 300 rpm for 5 minutes to obtain Morinda citrifolia microemulsion.

[0065] Component B comprises the following raw materials in parts by weight: 3 parts of Gleditsia sinensis extract, 3 parts of Platycladus orientalis leaf extract, 3 parts of Polygonum multiflorum extract, 3 parts of Ginseng extract, 1.2 parts of Houttuynia cordata extract, 4 parts of Sophora flavescens extract, 4 parts of Vitex rotundifolia extract, and 1.2 parts of Eclipta prostrata extract;

[0066] The preparation method of each extract is as follows: Gleditsia sinensis, Platycladus orientalis leaf, Polygonum multiflorum, ginseng, Houttuynia cordata, Sophora flavescens, Vitex rotundifolia and Eclipta prostrata are crushed, and then supercritical CO2 fluid extraction is performed at 30 MPa and 60°C for 60 min to obtain Gleditsia sinensis extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, ginseng extract, Houttuynia cordata extract, Sophora flavescens extract, Vitex rotundifolia extract and Eclipta prostrata extract, respectively.

[0067] The auxiliary materials include the following raw materials in parts by weight: 6 parts of chitosan / cationic guar gum composite gel, 0.4 parts of thickener, 3 parts of surfactant, and 600 parts of water.

[0068] The preparation method of the chitosan / cationic guar gum composite gel is as follows: 2.0% w / v chitosan solution and 2.0% w / v cationic guar gum solution are mixed in a volume ratio of 3:1, ultrasonically stirred, and adjusted to pH 5±0.5.

[0069] The preparation method of the above-mentioned antibacterial shampoo for preventing infection comprises the following specific steps:

[0070] (1) Preparation of component A: Agarwood microemulsion and Morinda citrifolia microemulsion were mixed, vortexed for 30 seconds, and Ganoderma lucidum fermentation liquid was added to obtain a mixed solution, followed by adding biopeptide, and ultrasonically treated at 60°C and 400W for 60 minutes to obtain component A;

[0071] (2) ultrafinely grinding each plant extract in component B into a particle size of 3±2 μm, and mixing them evenly to obtain component B;

[0072] (3) Component A and component B are mixed, added into 50 wt% water, mixed and stirred at 800 rpm and 35° C. for 30 min, chitosan / cationic guar gum composite gel is added, stirring is continued for 40 min, thickener, surfactant and balance water are added, stirred evenly, and the target shampoo is obtained.

[0073] Comparative Example 1

[0074] The difference from Example 1 is that component A lacks agarwood microemulsion, and the rest is consistent with Example 1.

[0075] Comparative Example 2

[0076] The difference from Example 1 is that component A lacks Morinda citrifolia microemulsion, and the rest is consistent with Example 1.

[0077] Comparative Example 3

[0078] The difference from Example 1 is that the active ingredient composition includes component A and component B in a mass ratio of 1:3, and the rest is consistent with Example 1.

[0079] Comparative Example 4

[0080] The difference from Example 1 is that component B lacks the Vitex rotundifolia extract, and the rest is the same as Example 1.

[0081] Comparative Example 5

[0082] The difference from Example 1 is that the auxiliary material lacks chitosan / cationic guar gum composite gel, and the rest is consistent with Example 1.

[0083] Test Example 1-Bacterial Inhibition Test

[0084] The shampoos prepared in Examples 1-3 and Comparative Examples 1-5 were tested for killing Malassezia furfur, Escherichia coli and Candida albicans;

[0085] Test bacteria: Malassezia furfur (ATCC 44344), Candida albicans (ATCC 10231), Escherichia coli (ATCC 25922);

[0086] Test basis: QB / T2738-2012 "Evaluation Methods for Antibacterial and Antimicrobial Effects of Daily Chemical Products", the test substances are exposed to the environment for 1min, 3min and 10min.

[0087] The results are shown in Table 1.

[0088] Table 1

[0089]

[0090] As can be seen from Table 1, compared with comparative examples 1-5, the shampoos prepared in Examples 1-3 of the present invention have an antibacterial rate of >99.9% against Malassezia furfur, Candida albicans and Escherichia coli, indicating that they can effectively inhibit bacteria, prevent infection, and are safe and non-irritating.

[0091] Test Example 2-Wound Repair Test

[0092] 50 mice (20 g ± 2 g) were modeled by hair removal incision on the back, and the wound was disinfected with iodine tincture and randomly divided into two groups. After 3 days, one group was cleaned with the shampoo of Example 1 of the present invention, wiped clean with sterile gauze, and then cleaned once every two days, and the other group was treated with clean water as a control group. The wound recovery was observed after half a month. Among them, the degree of healing = (initial wound area-current wound area) / initial wound area × 100%.

[0093] The experimental results are shown in Table 2.

[0094] Table 2

[0095] sample Wound healing Example 1 Healing rate 99%, no obvious scars Control group Healing degree 60%, with scars

[0096] It can be seen from Table 2 that, compared with the control group, the shampoo of Example 1 of the present invention can repair postoperative wounds and prevent infection.

[0097] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An antibacterial shampoo for preventing infection, characterized in that: It is composed of 5-10wt% active ingredient composition and 90-95wt% auxiliary materials; The active ingredient composition comprises component A and component B in a mass ratio of 2-4:1; The component A comprises the following raw materials in parts by weight: 2-4 parts of agarwood microemulsion, 2-4 parts of Morinda citrifolia microemulsion, 1-3 parts of ganoderma lucidum fermentation liquid, and 1-3 parts of biological peptide; The component B comprises the following raw materials in parts by weight: 1-3 parts of Gleditsia sinensis extract, 1-3 parts of Platycladus orientalis leaf extract, 1-3 parts of Polygonum multiflorum extract, 1-3 parts of Ginseng extract, 0.8-1.2 parts of Houttuynia cordata extract, 2-4 parts of Sophora flavescens extract, 2-4 parts of Vitex rotundifolia extract, and 0.8-1.2 parts of Eclipta prostrata extract; The auxiliary materials include the following raw materials in parts by weight: 4-6 parts of chitosan / cationic guar gum composite gel, 0.2-0.4 parts of thickener, 1-3 parts of surfactant, and 500-600 parts of water.

2. An antibacterial shampoo for preventing infection as claimed in claim 1, characterized in that: The preparation method of the agarwood microemulsion comprises: crushing fresh agarwood leaves and adding them into water, performing steam distillation to obtain agarwood essential oil, uniformly mixing the agarwood essential oil and an active agent, adding deionized water and performing vortex oscillation at the same time, and performing ultrasonic treatment to obtain the agarwood microemulsion; The preparation method of the Morinda citrifolia microemulsion comprises the following steps: pulping and crushing fresh Morinda citrifolia, adding the pulp into water, performing steam distillation to obtain Morinda citrifolia essential oil, uniformly mixing the Morinda citrifolia essential oil and Tween 60, adding deionized water and performing vortex oscillation at the same time, and performing ultrasonic treatment to obtain the Morinda citrifolia microemulsion.

3. An antibacterial shampoo for preventing infection as claimed in claim 2, characterized in that: In the preparation method of agarwood microemulsion, the solid-liquid ratio of the agarwood leaves to water is 1:6-10g / mL; the temperature of the steam distillation is 180-200°C, and the time is 4-6h; the active agent is Tween 20 and Span 20 in a mass ratio of 1:1-3; the mass ratio of the agarwood essential oil to the active agent is 1:3-5; the volume ratio of the deionized water to the agarwood essential oil is 3-5:1; the speed of the vortex oscillation is 1000-2000rpm, and the time is 1-3min; the time of the ultrasonic treatment is 3-5min, and the rotation speed is 200-300rpm; In the preparation method of Morinda citrifolia microemulsion, the solid-liquid ratio of Morinda citrifolia to water is 1:10-15g / mL; the temperature of the steam distillation is 180-200°C, and the time is 4-6h; the mass ratio of the Morinda citrifolia essential oil to Tween 60 is 1:2-4; the volume ratio of the deionized water to the Morinda citrifolia essential oil is 3-5:1; the speed of the vortex oscillation is 1000-2000rpm, and the time is 1-3min; the time of the ultrasonic treatment is 3-5min, and the rotation speed is 200-300rpm.

4. The antibacterial shampoo for preventing infection according to claim 1, characterized in that: The biological peptides are beta-casein phosphopeptide and beta-antimicrobial peptide in a mass ratio of 1:1-2.

5. The antibacterial shampoo for preventing infection according to claim 1, characterized in that: The preparation method of each plant extract of component B is: crushing sapodilla, Platycladus orientalis leaf, Polygonum multiflorum, ginseng, Houttuynia cordata, Sophora flavescens, Vitex rotundifolia and Eclipta prostrata, and extracting them respectively through a supercritical CO2 fluid extractor to obtain sapodilla extract, Platycladus orientalis leaf extract, Polygonum multiflorum extract, ginseng extract, Houttuynia cordata extract, Sophora flavescens extract, Vitex rotundifolia extract and Eclipta prostrata extract.

6. An antibacterial shampoo for preventing infection as claimed in claim 5, characterized in that: The supercritical CO2 fluid extraction has a pressure of 20-30 MPa, a temperature of 40-60°C, and a time of 30-60 min.

7. The antibacterial shampoo for preventing infection according to claim 1, characterized in that: The preparation method of the chitosan / cationic guar gum composite gel is as follows: 0.5%-2.0% w / v chitosan solution and 0.5%-2.0% w / v cationic guar gum solution are mixed in a volume ratio of 1-3:1, ultrasonically stirred, and adjusted to pH 4.5-6.

0.

8. The antibacterial shampoo for preventing infection according to claim 1, characterized in that: The thickener is an amino acid thickener PEG-120; the surfactant is sodium lauroyl glutamate and cocamidopropyl betaine in a mass ratio of 1:1-2.

9. The method for preparing an antibacterial shampoo for preventing infection according to claim 1, characterized in that: The specific steps include: (1) Preparation of component A: Agarwood microemulsion and Morinda citrifolia microemulsion were mixed, vortexed, and Ganoderma lucidum fermentation liquid was added to obtain a mixed solution, and then biological peptides were added and ultrasonicated to obtain component A; (2) ultrafinely grinding each plant extract in component B into a particle size of 1-5 μm and mixing them evenly to obtain component B; (3) Component A and component B are mixed, added into water with a formula amount of 40-50 wt%, mixed and stirred, chitosan / cationic guar gum composite gel is added, stirring is continued, thickener, surfactant and balance water are added, and stirred evenly to obtain the target shampoo.

10. The method for preparing an antibacterial shampoo for preventing infection according to claim 9, characterized in that: In step (1), the ultrasonic treatment is carried out at 40-60° C. and 300-400W for 40-60 min; In step (3), the mixing and stirring is carried out at a speed of 600-800 rpm, a temperature of 25-35° C., and a time of 20-30 min; and the stirring is continued for 30-40 min.

Images