Ion dissociation device, control method and mass spectrometer

Abstract

The invention relates to an ion dissociation device, a control method and a mass spectrometer. The ion dissociation device comprises an inlet electrode, a first transmission electrode, a first grid mesh, a magnet, an electron source, a second grid mesh and an outlet electrode which are sequentially arranged, the inlet electrode and the outlet electrode are respectively provided with a first hole and a second hole for ions to be output to pass through; a reaction space is defined by the magnet, the first grid mesh and the second grid mesh, and the electron source extends into the reaction space; a containing space is defined by the inlet electrode, the first transmission electrode and the first grid mesh, and the voltage of the inlet electrode, the voltage of the first transmission electrode, the voltage of the first grid mesh, the voltage of the magnet and the voltage of the second grid mesh are independently adjustable. Through the arrangement, ion storage and accumulation are carried out while ion reaction is carried out, the ion utilization rate is improved, and the path of subsequent ions entering the reaction space is shortened, so that the ion response speed is improved, long-time trapping can be realized, and ion loss is reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of mass spectrometers, and in particular to an ion dissociation device, a control method and a mass spectrometer. Background Art

[0002] Mass spectrometer is a very important analytical tool in the field of modern analytical chemistry, with high detection sensitivity and powerful qualitative and quantitative analysis capabilities. Tandem mass spectrometry is also a very important analytical method in mass spectrometers. This technical method plays a very important role in the identification of new chemical substances and analysis of molecular structures by mass spectrometers. An important component of a mass spectrometer is an ion dissociation device, which generally dissociates ions and reacts them to perform qualitative and quantitative analysis on the object to be detected. There are various ways of ion dissociation, among which collision-induced dissociation, photon-induced dissociation, electron-induced dissociation, charge transfer dissociation, etc. are commonly used. In the dissociation method, the ion reaction usually involves the reaction of positively or negatively charged ions with another charged substance, which can be another negatively or positively charged ion or electron. For example, in electron induced dissociation (EID), the charged substance is an electron beam, and the electron impact on the ion causes the ion to fragment.

[0003] Existing ion dissociation devices generally adopt DC voltage drive or radio frequency drive mode. The DC voltage drive mode is not conducive to long-term ion trapping during collision-induced dissociation reactions of milliseconds or longer, and will cause certain ion losses. In the radio frequency voltage drive mode, the electron transmission rate for electron introduction is low and the ion response speed is slow, resulting in poor reaction effect. Summary of the invention

[0004] To this end, the technical problem to be solved by the present invention is to overcome the problem in the prior art that when DC voltage is used for driving, it is not conducive to the long-term trapping of ions and will cause certain ion losses. In the RF voltage driving mode, the electron transmission rate for electron introduction is low and the reaction effect is poor, thereby providing an ion dissociation device, a control method and a mass spectrometer.

[0005] In order to solve the above technical problems, the present invention provides an ion dissociation device, comprising: An entrance electrode, a first transmission electrode, a first grid, a magnet, an electron source, a second grid and an exit electrode are sequentially arranged; The inlet electrode and the outlet electrode are respectively provided with a first hole and a second hole for the ions to be transmitted to pass through; A reaction space is surrounded by the magnet, the first grid and the second grid, and the electron source is arranged in the reaction space; An accommodating space is surrounded by the inlet electrode, the first transmission electrode and the first grid. The voltages of the inlet electrode, the first grid and the second grid are independently adjustable to control the time for the ions to be output to pass through or stay in the accommodating space and the reaction space.

[0006] In one embodiment of the present invention, a second transmission electrode is further arranged between the second grid and the outlet electrode.

[0007] In one embodiment of the present invention, it also includes a shell, the shell is in a vacuum environment, the two ends of the shell are respectively provided with an input port and an output port, the input electrode and the output electrode are end cap electrodes, the input electrode and the output electrode are respectively arranged at the input port and the output port, the first transmission electrode, the first grid, the magnet, the electron source, the second grid and the second transmission electrode are arranged in the shell.

[0008] In one embodiment of the present invention, the first transmission electrode applies a radio frequency voltage and / or a first DC voltage, the second transmission electrode applies a radio frequency voltage and / or a second DC voltage, the first DC voltage and the second DC voltage are equal or unequal, the entrance electrode and the exit electrode apply a third DC voltage and a fourth DC voltage, respectively, and the first grid and the second grid apply an eighth DC voltage and a ninth DC voltage, respectively.

[0009] In one embodiment of the present invention, the electron source is a filament, and the filament applies current and a seventh DC voltage through a filament electrode. The magnet includes a first magnet and a second magnet, and a fixing seat is arranged between the first magnet and the second magnet. The filament is arranged on the fixing seat to pass through the reaction space.

[0010] In one embodiment of the present invention, a DC voltage can be applied to the first magnet and the second magnet.

[0011] In one embodiment of the present invention, the center lines of the entrance electrode, the first transmission electrode, the second transmission electrode, the first magnet, the second magnet, the first grid and the second grid are the same, and the filament is arranged to be orthogonal to the center line.

[0012] In one embodiment of the present invention, the voltages of the first grid and the first magnet are the same or different, and the voltages of the second magnet and the second grid are the same or different.

[0013] In one embodiment of the present invention, the first transmission electrode or the second transmission electrode is composed of a plurality of sub-electrodes, the radio frequency phases of adjacent sub-electrodes differ by 180°, and the radio frequency amplitude is adapted to the mass of the ions to be output.

[0014] The present invention also provides a control method for an ion dissociation device, which uses the above-mentioned ion dissociation device to output dissociated ions, comprising the following steps: Step S1: adjusting the second grid voltage to be greater than the voltages of the magnet, the first transmission electrode, the first grid and the entrance electrode, and introducing the ions to be transmitted into the reaction space; Step S2: adjusting the voltages of the first grid and the second grid to be greater than the voltage of the magnet, trapping the ions to be transmitted that enter the reaction space, and making the voltage of the first grid greater than the voltage of the first transmission electrode and the entrance electrode, so that the other part of the ions to be transmitted accumulate in the accommodating space; Step S3: generating electrons through an electron source, and the electrons collide with the ions to be dissociated in the reaction space to cause them to fragment and dissociate; Step S4: adjusting the voltage of the first grid to be greater than the voltages of the magnet, the second grid and the exit electrode, so as to lead the dissociated ions out of the exit electrode.

[0015] In one embodiment of the present invention, after step S4, the method further includes continuing to introduce ions, which includes the following steps: Step S5: adjust the second grid so that its voltage is greater than the voltage of the magnet, the first transmission electrode, the first grid and the entrance electrode, and the voltages of the magnet, the first transmission electrode, the first grid and the entrance electrode are equal or unequal, and simultaneously introduce external ions into the accommodating space, and introduce the ions to be transmitted accumulated in the accommodating space into the reaction space.

[0016] In one embodiment of the present invention, while executing steps S1, S2, S3, and S4, ions can be stored between the entrance electrode and the first grid electrode. After the reaction of the reactive ions is completed, the stored ions can directly enter the reaction space, thereby improving the utilization rate of the ions.

[0017] The present invention also provides a mass spectrometer, comprising the above-mentioned ion dissociation device.

[0018] The ion dissociation device described in the present invention has the following advantages over the prior art: 1. When ions are dissociating and fragmenting, the accommodating space can simultaneously accumulate ions, so that the ions are accumulated and trapped in the accommodating space, which improves the ion utilization rate and shortens the path for subsequent ions to enter the reaction space, thereby improving the ion response speed, and can trap ions for a long time, reducing ion loss and ensuring the reaction effect.

[0019] 2. It is suitable for driving the movement of ions to be transmitted by using one or more modes of radio frequency mode, direct current mode and magnetic field mode. In any of the above modes, the ion response speed can be guaranteed, and the ions can be trapped for a long time to reduce ion loss.

[0020] 3. The reaction pool structure is formed by the action of radio frequency, direct current and magnetic field. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to make the content of the present invention more clearly understood, the present invention is further described in detail below according to specific embodiments of the present invention in conjunction with the accompanying drawings, wherein Figure 1 It is a schematic structural diagram of the ion dissociation device when the transmission electrode of the present invention adopts a quadrupole form; Figure 2 It is a schematic structural diagram of the ion dissociation device when the transmission electrode of the present invention adopts the PCB form; Figure 3 It is a DC voltage variation diagram of each module of the present invention in the ion introduction stage, reaction stage and extraction stage respectively; Figure 4 It is a schematic diagram of the structure of the quadrupole, octopole type transmission electrode and sheet transmission electrode of the present invention; Figure 5 It is a flow chart of the control method of the ion dissociation device of the present invention.

[0022] Explanation of the reference numerals in the specification: 1. entrance electrode; 2. first transmission electrode; 3. first grid; 4. first magnet; 5. filament fixing seat 5; 6. second magnet; 7. second grid; 8. second transmission electrode; 9. exit electrode; 10. filament; 11. filament base. DETAILED DESCRIPTION

[0023] The present invention is further described below in conjunction with the accompanying drawings and specific embodiments so that those skilled in the art can better understand the present invention and implement it, but the embodiments are not intended to limit the present invention. Embodiment 1

[0024] Reference Figure 1-Figure 5 As shown, an ion dissociation device of the present invention comprises: An entrance electrode 1, a first transmission electrode 2, a first grid 3, a magnet, an electron source, a second grid 7 and an exit electrode 9 are arranged in sequence; The inlet electrode 1 and the outlet electrode 9 are respectively provided with a first hole and a second hole for the ions to be transmitted to pass through; A reaction space is surrounded between the magnet, the first grid 3 and the second grid 7, and the electron source is arranged in the reaction space; An accommodation space is surrounded by the entrance electrode 1, the first transmission electrode 2 and the first grid 3. The voltages of the entrance electrode 1, the first grid 3 and the second grid 7 are independently adjustable to control the time for the ions to be transmitted to pass through or stay in the accommodation space and the reaction space.

[0025] An ion dissociation device described in the present invention provides initial voltages to the entrance electrode 1, the first grid 3 and the second grid 7 respectively during the ion introduction stage, so that the ions to be transmitted enter the accommodating space and the reaction space in turn through the first hole of the entrance electrode 1; during the reaction stage, the voltages of the first grid 3 and the second grid 7 are increased so that the ions in the reaction space are trapped, and when the ions react, the accommodating space can trap the ions that continue to enter, so that the ions to be reacted can continue to accumulate in the accommodating space; during the reaction stage, electrons are generated by an electron source, so that the charge carried by the ions changes, thereby forming ion fragments, which are then led out through the second hole of the exit electrode 9.

[0026] In the ion introduction stage, ions enter between the two grids through the entrance electrode 1; in the ion reaction stage, the target ions react with the electrons generated by the electron source 10 to generate target fragment ions, and this process usually takes dozens to tens of milliseconds; in the ion extraction stage, the fragment ions are delayed to the second transmission electrode 8 and enter the subsequent structure through the exit electrode 9 for analysis.

[0027] A second transmission electrode 8 is further arranged between the second grid 7 and the outlet electrode 9 . The ion fragments after the reaction pass through the second transmission electrode 8 and are then led out from the second hole of the outlet electrode 9 .

[0028] The first hole of the inlet electrode 1 and the second hole of the outlet electrode 9 have a size of 0.5 mm to 5 mm.

[0029] The DC voltage used to drive the entrance electrode 1, the first transmission electrode 2, the first grid 3, the magnet, the electron source, the second grid 7, the exit electrode 9 and the second transmission electrode 8 is in the range of -500V to 500V, and all of them are individually adjustable.

[0030] It also includes a shell, the inside of the shell is a vacuum environment, the two ends of the shell are respectively provided with an input port and an output port, the inlet electrode 1 and the outlet electrode 9 are end cover electrodes, the inlet electrode 1 and the outlet electrode 9 are respectively arranged at the input port and the output port, and are sealed with the shell to form the entire reaction pool, the first transmission electrode 2, the first grid 3, the magnet, the electron source, the second grid 7 and the second transmission electrode 8 are arranged in the shell.

[0031] The entrance electrode 1, the first transmission electrode 2, the first grid 3, the magnet, the electron source, the second grid 7, the exit electrode 9 and the second transmission electrode 8 are under the same vacuum condition, and each module is supported by an insulating structure with an insulation thickness of 0.1 mm to 3 mm; The first transmission electrode 2 applies an RF voltage and / or a first DC voltage, and the second transmission electrode 8 applies an RF voltage and / or a second DC voltage. The first DC voltage and the second DC voltage are equal or unequal. The circuit structure including the driving structure enables the first transmission electrode 2 to apply an RF voltage RF and a DC voltage DC1, and the second transmission electrode 8 to apply an RF voltage RF and a second DC voltage DC2. The first transmission electrode 2 and the second transmission electrode 8 may also only apply a DC voltage.

[0032] The inlet electrode 1 and the outlet electrode 9 are applied with a third DC voltage DC3 and a fourth DC voltage DC4, respectively. The first grid 3 and the second grid 7 are applied with an eighth DC voltage DC8 and a ninth DC voltage DC9, respectively.

[0033] The electron source includes a filament 10, and the filament 10 is applied with current and a seventh DC voltage DC7 by a current-controllable and voltage-controllable power supply module through a filament electrode. The magnet includes a first magnet 4 and a second magnet 6. A fixing seat 5 and a filament bracket 11 are arranged between the first magnet 4 and the second magnet 6, which can be a filament power supply structure and is electrically connected to the filament 10. The filament 10 is arranged on the fixing seat 5 and the filament bracket 11. The material of the filament 10 is preferably a conductive structure such as tungsten wire, tungsten rhenium wire, rhenium iridium wire, etc. Figure 4 As shown, specifically, the filament fixing seat 5 can be a circular ring structure, and the filament support 11 and the filament 10 can be fixed in the middle position; The voltage control range of the filament 10 is 0V~100V, and the current range is 0~5A, and both the current and voltage can be adjusted and controlled.

[0034] The center lines of the entrance electrode 1, the first transmission electrode 2, the second transmission electrode 8, the first magnet 4, the second magnet 6, the first grid 3 and the second grid 7 are the same, the filament is arranged to be orthogonal to the center line, and the magnet is preferably a circular permanent magnet; the two planes of the ring are N level and S level respectively.

[0035] The voltages of the first grid 3 and the first magnet 4 may be the same or different, and the voltages of the second magnet 6 and the second grid 7 may be the same or different. In the present embodiment, the voltages of the two are respectively the same to reduce and optimize the voltage control steps without affecting the ion trapping and accumulation effects. The first magnet 4 and the second magnet 6 may apply a DC voltage. Specifically, the first magnet 4 and the second magnet 6 apply a fifth DC voltage DC5 and a sixth DC voltage DC6, respectively.

[0036] like Figure 4As shown, the first transmission electrode 2 or the second transmission electrode 8 is composed of a plurality of sub-electrodes, the RF phases of adjacent sub-electrodes differ by 180°, and the RF amplitude is adapted to the mass of the ions to be transmitted. Specifically, the first transmission electrode 2 and the second transmission electrode 8 may be transmission devices composed of cylindrical or square or triangular or sheet structures composed of PCB, that is, the sub-electrodes may be cylindrical electrodes or sheet electrodes; preferably, a transmission electrode composed of a cylinder is used, which may be a quadrupole, a hexapole, an octopole or a dodecapole. The first transmission electrode 2 and the second transmission electrode 8 may also be composed of PCB, and be composed of a plurality of separate structures, and the phases of adjacent pole pieces of the transmission electrode composed of PCB differ by 180°.

[0037] Preferably, the RF amplitude and frequency of the first transmission electrode 2 and the second transmission electrode 8 can be the same, and the RF phase difference between adjacent rods or adjacent pole pieces is 180°. The RF amplitude varies with the change of the transmission ion mass range. Embodiment 2

[0038] This embodiment discloses an ion dissociation device, which is different from the first embodiment in that: Figure 1 As shown, the transmission electrode selects a quadrupole as the transmission structure, with a diameter of 8.9mm, an inner diameter of 9.14mm, an applied RF amplitude peak-to-peak value of 300V, and a frequency of 1MHz; the thickness of the through hole between the entrance electrode 1 and the exit electrode 9 is 1mm, and the diameter is 2.5mm; the magnet selects a permanent magnet, and the S and N of the two magnets are placed in sequence, with a width of 5mm and an inner diameter of 5mm; the filament holder 5 is made of PEEK material with an inner diameter of 5mm; the filament 10 is made of rhenium tungsten filament 10, which crosses the inner hole and is arranged in a spiral shape. The grid uses stainless steel wire with a wire diameter of 0.05mm and a distance between the wires of 0.4mm to form a grid structure. The vacuum of the reaction cell is 0.1Pa. The voltage of the filament 10 changes with the cycle of the reaction. During the reaction, the voltage is 5V and the current is 1.2A.

[0039] In the ion introduction, reaction, and extraction stages, examples of voltage conditions for each part are shown in Table 1 below: Table 1 Electrode number DC voltage (introduction phase) DC voltage (reaction phase) DC voltage (extraction stage) 1. Inlet electrode 5V 5V 5V 2. First transmission electrode 5V 5V 5V 3. The first grid 5V 15V 20V 4. The first magnet 5V 15V 20V 10. Filament voltage and current 5V, 1.2A 5V, 1.2A 15V, 0.1A 6. Second magnet 15V 15V 10V 7. Second grid 15V 15V 10V 8. Second transmission electrode 15V 15V 5V 9.Export electrode 15V 15V 5V The ion introduction time is set to 10ms, the reaction time is 30ms, and the extraction time is 5ms. The DC voltage changes of different electrodes at each stage are shown in the figure above. In the ion introduction stage, the entrance electrode 1 is opened, and the ions enter the reaction pool and stabilize between the grids; then in the ion reaction stage, the voltage of the first grid 3 increases, and the subsequent ions are stored in the accommodating space, and ion accumulation is performed; in the ion introduction and ion reaction stages, the ions in the reaction pool have a certain reaction probability with the electrons to achieve ion fragmentation; then in the extraction stage, the voltage of the first grid 3 increases, and the voltage of the second grid 7 decreases, and the unreacted ions and the fragmented ions generated by the reaction are all extracted to the second transmission electrode 8, and then extracted to the back-end device through the exit electrode 9 for mass analysis. After the extraction stage is completed, the next round of ion introduction stage is restarted, the voltage of the first grid 3 decreases, and the voltage of the second grid 7 increases. At this time, since ions are accumulated in the first transmission electrode 2, the accumulated ions can be directly introduced into the reaction space between the first screen and the second screen for reaction.

[0040] In this embodiment, the first transmission electrode 2 acts as a storage space for subsequent ions during the reaction stage of the ions. When the first transmission electrode 2 is used only as a transmission structure, the ions can pass stably according to the adjustment voltage of the ion channel. Embodiment 3

[0041] This embodiment discloses an ion dissociation device, which is different from the first embodiment in that: Figure 2 As shown, the transmission electrode selects a sheet PCB electrode with a through hole in the middle as the transmission structure, the internal hole diameter is 8mm, the thickness is 1mm, the adjacent electrodes are separated by a 1mm spacer, the applied RF amplitude peak-to-peak value is 200V, the frequency is 1MHz, and the phase difference between adjacent pole pieces is 180°; the thickness of the through hole between the entrance electrode 1 and the exit electrode 9 is 1mm, and the diameter is 2.5mm; the magnet selects a permanent magnet, the S and N of the first magnet 4 and the second magnet 6 are placed in sequence, the width is 5mm, and the inner diameter is 5mm; the filament fixing seat 5 is made of PEEK material with an inner diameter of 10mm; the filament 10 is made of tungsten wire, which crosses the inner hole and is arranged in a spiral shape. The grid uses tungsten wire with a wire diameter of 0.03mm and a distance between the wires of 0.5mm to form a grid structure. The vacuum of the reaction cell is 0.05Pa.

[0042] All electrodes are coaxial. When the energy of the filament 10 is high, the fragmentation reaction of the ions is intense and the reaction time is short. In this process, the electrodes are only used to control the switch of the reaction pool. When the reaction pool is closed, the electrical control of each electrode is shown in Table 2 below: Table 2 Electrode number Open closure 1. Inlet electrode 43V 43V 2. First transmission electrode 40V 43V 3. The first grid 30V 30V 4. The first magnet 30V 30V 10. Filament voltage and current 35V, 2.6A 35V, 0A 6. Second magnet 30V 30V 7. Second grid 15V 30V 8. Second transmission electrode 10V 38V 9.Export electrode 15V 40V When the reaction cell is turned on, the filament 10 releases a certain number of electrons to react with the ions entering the reaction cell, and after the reaction, the ions directly enter the analyzer through the magnet, the transmission electrode and the exit electrode 9. When the reaction cell is closed, the ions are focused in the reaction cell, there are no electrons in the reaction cell, and no fragmentation reaction occurs. Embodiment 4

[0043] This embodiment discloses a control method for an ion dissociation device, which uses an ion dissociation device as described in any one of Embodiments 1-3 to output dissociated ions, comprising the following steps: Step S1: adjusting the voltage of the second grid 7 to be greater than the voltages of the magnet, the first transmission electrode 2, the first grid 3 and the entrance electrode 1, so as to introduce the ions being transmitted into the reaction space; Specifically, the voltage of the outlet electrode 9 is made greater than the voltage of the second grid 7, and the voltage of the second grid 7 > the magnet voltage = the voltage of the first grid 3, the first transmission electrode 2 and the inlet electrode 1, so that ions can enter the accommodating space and the reaction space and are difficult to pass through the second grid 7 and the outlet electrode 9.

[0044] Step S2: adjusting the voltage of the first grid 3 and the second grid 7 to be greater than the voltage of the magnet, trapping the ions entering the reaction space, and making the voltage of the first grid 3 greater than the first transmission electrode 2 and the entrance electrode 1, so that the subsequent entering ions accumulate in the accommodating space; Specifically, the voltages of the first grid 3 , the second grid 7 and the exit electrode 9 are made the same and greater than the magnet voltage, and greater than the voltages of the entrance electrode 1 and the first transmission electrode 2 .

[0045] Step S3: generating electrons through an electron source, and the electrons collide with the trapped ions in the reaction space to cause them to fragment and dissociate; Step S4: adjusting the voltage of the first grid 3 to be greater than the voltages of the magnet, the second grid 7 and the outlet electrode 9, so as to lead the dissociated ions out of the outlet electrode 9.

[0046] Specifically, the voltage of the first grid 3 is made greater than the voltages of the entrance electrode 1, the first transmission electrode 2, the magnet, the second grid 7 and the exit electrode 9. In this process, when the voltage of the first grid 3 is increased, the voltage of the second grid 7 is lowered before or at least simultaneously, so that the second grid 7 does not hinder the extraction of dissociated ions, and can prevent the undissociated ions from mixing with the dissociated ions through the first grid 3. Specifically, in this embodiment, after the voltage of the first grid 3 is increased, the voltage of the second grid 7 can be returned to the initial state before the adjustment in step S1, so as to facilitate the repeated entry into the voltage state of the ion introduction stage of step S1; the voltage of the second grid 7 can also be further lower than the voltage state in step S1, so as to further accelerate the extraction of ions; and the voltage of the exit electrode 9 is not higher than the voltage of the second grid 7.

[0047] While executing steps S1, S2, S3, and S4, ions can be stored between the entrance electrode and the first grid electrode. After the reaction of the reactive ions is completed, the stored ions can directly enter the reaction space, thereby improving the utilization rate of the ions.

[0048] After step S4, the method further includes continuing to introduce ions, which includes the following steps: Step S5: adjust the voltage of the second grid 7 so that it is greater than the voltage of the magnet, the first transmission electrode 2, the first grid 3 and the entrance electrode 1, and the voltages of the magnet, the first transmission electrode 2, the first grid 3 and the entrance electrode 1 are equal, and the external ions are introduced into the accommodation space synchronously, and the ions to be transmitted accumulated in the accommodation space are introduced into the reaction space. In this process, the voltage of the first grid 3 can be reduced so that its voltage is not higher than the entrance electrode 1 and the first transmission electrode 2 to avoid it hindering the introduction of new ions and accumulated ions; the voltage of the first grid 3 can also be kept equal to the voltage of the magnet, the first transmission electrode 2, and the entrance electrode 1, so as to facilitate the operation of repeatedly entering the ion introduction stage in step S1. The voltage size in this embodiment takes positively charged ions as an example.

[0049] When a second transmission electrode 8 is provided, in step S1, the voltage of the second transmission electrode 8 is not greater than the voltage of the outlet electrode 9 and not less than the voltage of the second grid 7; in steps S2 and S4, the voltage of the second transmission electrode 8 is equal to the voltages of the second grid 7 and the outlet electrode 9.

[0050] The device adopts a reaction pool structure formed by the action of radio frequency, direct current and magnetic field. The accommodating space can accumulate ions simultaneously during the ion reaction process, thereby improving the ion utilization rate. When the next reaction stage is started, the accumulated ions can directly enter the reaction space in an enriched state, thereby improving the ion response speed. The ions accumulated by the first transmission electrode 2 are subsequently introduced between the first screen and the second screen for reaction. Since the filament 10 of the device is directly inserted into the reaction pool, the collision efficiency between electrons and ions is improved compared with the traditional structure. The action of the magnetic field enables electrons to better contact and react with ions. Embodiment 5

[0051] This embodiment discloses a mass spectrometer, including an ion dissociation device as described in the first embodiment.

[0052] A mass spectrometer described in this embodiment also includes a mass analyzer. Ions enter from the entrance electrode 1 of the ion reaction device, and react with the electrons emitted by the filament 10 to generate new charged ions, which are introduced into the mass analyzer from the exit electrode 9; the ions, ion fragments or atoms obtained by the ion reaction device can be analyzed. It can also include a device for generating a vacuum environment, an ion generating device, an analysis control module and a human-computer interaction device. According to the actual application scenario, the material detection instrument used by the ion dissociation device of the present invention can include or be replaced by various mass spectrometers, ion mobility spectrometers, chromatographs, spectrometers, electrochemical analyzers, etc.

[0053] Obviously, the above embodiments are merely examples for clear explanation and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived from these are still within the protection scope of the invention.

Claims

1. An ion dissociation device, characterized in that: include: An entrance electrode, a first transmission electrode, a first grid, a magnet, an electron source, a second grid and an exit electrode are sequentially arranged; The inlet electrode and the outlet electrode are respectively provided with a first hole and a second hole for the ions to be transmitted to pass through; A reaction space is surrounded by the magnet, the first grid and the second grid, and the electron source is arranged in the reaction space; An accommodating space is surrounded by the inlet electrode, the first transmission electrode and the first grid. The voltages of the inlet electrode, the first grid and the second grid are independently adjustable to control the time for the ions to be output to pass through or stay in the accommodating space and the reaction space.

2. An ion dissociation device according to claim 1, characterized in that: A second transmission electrode is also arranged between the second grid and the exit electrode.

3. An ion dissociation device according to claim 1, characterized in that: It also includes a shell, the shell is in a vacuum environment, the two ends of the shell are respectively provided with an input port and an output port, the input electrode and the output electrode are end cap electrodes, the input electrode and the output electrode are respectively arranged at the input port and the output port, the first transmission electrode, the first grid, the magnet, the electron source, the second grid and the second transmission electrode are arranged in the shell.

4. An ion dissociation device according to claim 2, characterized in that: The first transmission electrode applies a radio frequency voltage and / or a first DC voltage, the second transmission electrode applies a radio frequency voltage and / or a second DC voltage, the first DC voltage and the second DC voltage are equal or unequal, the entrance electrode and the exit electrode apply a third DC voltage and a fourth DC voltage respectively, and the first grid and the second grid apply an eighth DC voltage and a ninth DC voltage respectively.

5. An ion dissociation device according to claim 1, characterized in that: The electron source is a filament, and the filament applies current and a seventh DC voltage through a filament electrode. The magnet includes a first magnet and a second magnet, and a fixing seat is arranged between the first magnet and the second magnet. The filament is arranged on the fixing seat to pass through the reaction space.

6. An ion dissociation device according to claim 5, characterized in that: A direct current voltage may be applied to the first magnet and the second magnet.

7. An ion dissociation device according to claim 5, characterized in that: The center lines of the entrance electrode, the first transmission electrode, the second transmission electrode, the first magnet, the second magnet, the first grid and the second grid are the same, and the filament is arranged to be orthogonal to the center line.

8. An ion dissociation device according to claim 1, characterized in that: The first transmission electrode or the second transmission electrode is composed of a plurality of sub-electrodes, the radio frequency phases of adjacent sub-electrodes differ by 180°, and the radio frequency amplitude is adapted to the mass of the ions to be transmitted.

9. A method for controlling an ion dissociation device, characterized in that: Outputting dissociated ions using an ion dissociation device as described in any one of claims 1 to 8 comprises the following steps: Step S1: adjusting the second grid voltage to be greater than the voltages of the magnet, the first transmission electrode, the first grid and the entrance electrode, and introducing the ions to be transmitted into the reaction space; Step S2: adjusting the voltages of the first grid and the second grid to be greater than the voltage of the magnet, trapping the ions to be transmitted that enter the reaction space, and making the voltage of the first grid greater than the voltage of the first transmission electrode and the entrance electrode, so that the other part of the ions to be transmitted accumulate in the accommodating space; Step S3: generating electrons through an electron source, and the electrons collide with the ions to be dissociated in the reaction space to cause them to fragment and dissociate; Step S4: adjusting the voltage of the first grid to be greater than the voltages of the magnet, the second grid and the exit electrode, so as to lead the dissociated ions out of the exit electrode.

10. The control method of an ion dissociation device according to claim 9, characterized in that: While executing steps S1, S2, S3, and S4, ions can be stored between the entrance electrode and the first grid electrode. After the reaction of the reactive ions is completed, the stored ions can directly enter the reaction space, thereby improving the utilization rate of the ions.

11. The control method of an ion dissociation device according to claim 9, characterized in that: After step S4, the method further includes continuing to introduce ions, which includes the following steps: Step S5: adjusting the second grid to make its voltage greater than the voltage of the magnet, the first transmission electrode, the first grid and the entrance electrode, synchronously introducing external ions into the accommodating space, and introducing the ions to be transmitted accumulated in the accommodating space into the reaction space.

12. A mass spectrometer, characterized in that: It comprises an ion dissociation device as described in any one of claims 1 to 8.

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