Sunscreen and whitening composition as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a sunscreen and whitening composition as well as a preparation method and application thereof. According to the present invention, a variety of functional raw materials are matched, wherein the functional raw materials comprise ethylhexyl triazinone, diethylaminohydroxybenzoyl hexyl benzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine, nicotinamide, glabridin, an ascorbic acid derivative, sodium hyaluronate, bisabolol, dipotassium glycyrrhizinate, aloe juice, squalane, a ligusticum wallichii extract and a scutellaria baicalensis extract; according to the invention, the UVA and UVB are blocked in a synergistic full-wave band manner, the five effects of sunscreen, whitening, moisturizing, soothing and repairing are provided, the problem that many products in the market are single in sunscreen effect and do not have the whitening and skin care effects is solved, and an effective skin care protection function is provided for the skin.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and specifically relates to a sunscreen and whitening composition and a preparation method and application thereof. Background Art

[0002] Ultraviolet rays are the main cause of skin cancer and skin aging. Ultraviolet rays can damage the skin through the following mechanisms: 1. Damage to DNA. 2. Cross-linking of progressive proteins (such as collagen). 3. Reducing immune response by inducing inhibitory pathways of antigen stimulation. 4. Producing highly reactive free radicals that interact with various intracellular structures and cause cell and tissue damage.

[0003] There are many sunscreen products on the market, but these products generally only have a single sunscreen function and have poor whitening and skin care protection effects. Summary of the invention

[0004] In order to solve the above problems, the present invention combines a variety of functional ingredients to synergistically block UVA and UVB in the entire band, and provides five-fold effects of sun protection, whitening, moisturizing, soothing and repairing, which solves the gap that many products on the market are only sun protection but do not have whitening and skin care effects, and provides effective skin care protection function for the skin.

[0005] Specifically, the present invention provides a sunscreen composition comprising the following raw materials: bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, diethylaminohydroxybenzoyl hexyl benzoate, niacinamide, glycyrrhizin, ascorbic acid derivatives, sodium hyaluronate, bisabolol, dipotassium glycyrrhizinate, aloe juice, squalane, ligusticum chuanxiong extract and scutellaria baicalensis extract.

[0006] Furthermore, the mass percentage content of the raw materials in the sunscreen composition is: ethylhexyl triazone 0.2%-3.5%, diethylamino hydroxybenzoyl hexyl benzoate 0.2%-5.5%, bis-ethylhexyloxyphenol methoxyphenyl triazine 0.2%-5.0%, niacinamide 0.01%-3.0%, glabridin 0.00001%-0.1%, ascorbic acid derivative 0.01%-0.5%, sodium hyaluronate 0.001%-0.2%, bisabolol 0.1%-0.3%, dipotassium glycyrrhizinate 0.001%-0.2%, aloe juice 0.1%-3.0%, squalane 0.05%-3.0%, chuanxiong extract 0.5%-2.0% and scutellaria baicalensis extract 1.0%-2.0%.

[0007] Furthermore, the mass percentage content of the raw materials in the sunscreen composition is: 1.0% of ethylhexyl triazone, 5.0% of bis-ethylhexyloxyphenol methoxyphenyl triazine, 1.5% of diethylaminohydroxybenzoyl hexyl benzoate, 0.5% of niacinamide, 0.002% of glycyrrhizin, 0.11% of ascorbic acid derivative, 0.01% of sodium hyaluronate, 0.2% of bisabolol, 0.1% of dipotassium glycyrrhizinate, 0.9% of aloe juice, 0.2% of squalane, 1.0% of chuanxiong extract and 1.5% of scutellaria baicalensis extract.

[0008] Furthermore, the composition also contains: 10-16% of cyclopentasiloxane, 4-9% of polydimethylsiloxane, 1.5-6.5% of PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 6-12% of polyol, 0.8-3% of disteardimonium hectorite, 4-6% of isohexadecane, 0-0.5% of preservative, 0-3% of pigment and the balance of water.

[0009] Further, the polyol includes at least one of glycerol, butanediol and 1,2-hexanediol.

[0010] Furthermore, the ascorbic acid derivative is 3-o-ethyl ascorbic acid.

[0011] Furthermore, the preservative includes phenoxyethanol.

[0012] Furthermore, the pigment comprises CI 77891.

[0013] Furthermore, the Chuanxiong extract is prepared as follows: take Chuanxiong medicinal materials, crush and sieve, put them into a subcritical fluid extraction tank, add subcritical fluid, extract 2-3 times at 35-55°C, the extraction time is 30-60min, separate the extractant, and recover the Chuanxiong volatile oil to obtain the extract.

[0014] Furthermore, the scutellaria baicalensis extract is prepared as follows: take scutellaria baicalensis medicinal materials, crush and sieve, put them into a subcritical fluid extraction tank, add subcritical fluid, extract 2-3 times at 35-55°C, the extraction time is 30-60min, separate the extractant, and recover the scutellaria baicalensis volatile oil to obtain the product.

[0015] Furthermore, the subcritical fluid is butane.

[0016] On the other hand, the present invention also provides a method for preparing the sunscreen composition described herein, comprising the following steps:

[0017] Ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine, squalane, cyclopentasiloxane, polydimethylsiloxane, PEG-9 polydimethylsiloxyethyl polydimethicone, isohexadecane, and polyol are heated and stirred to obtain an oil phase;

[0018] Heat and stir water, niacinamide, glabridin, ascorbic acid derivatives, sodium hyaluronate, bisabolol, dipotassium glycyrrhizinate, and disteardimethylammonium hectorite to obtain an aqueous phase;

[0019] The oil phase is added to the water phase, stirred and mixed, cooled, and then the remaining raw materials are added, stirred and mixed to obtain a sunscreen composition.

[0020] Furthermore, when the oil phase is prepared, the heating temperature is 70-85° C. and the time is 0.1-1 hour.

[0021] Furthermore, when the oil phase is prepared, the heating temperature is 40-50° C. and the time is 0.1-1 hour.

[0022] Furthermore, the oil phase is added to the water phase, stirred and mixed for 0.1-1 hour, cooled to 25-37° C., and then the remaining raw materials are added, stirred and mixed for 0.1-1 hour to obtain a sunscreen composition.

[0023] On the other hand, the present invention also provides the use of the sunscreen composition described herein in the preparation of sunscreen, whitening, moisturizing, soothing and repairing cosmetics.

[0024] Beneficial effects of the present invention:

[0025] Based on the problem that sunscreen products on the market only have single sunscreen and poor whitening and skin care protection effects, the present invention combines a variety of functional raw materials to synergistically block UVA and UVB in the entire band, and provides five-fold effects of sunscreen, whitening, moisturizing, soothing, and repairing. Specifically, the present invention covers a variety of raw materials, including bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, niacinamide, glabridin, VC derivatives (ascorbic acid derivatives), sodium hyaluronate, bisabolol, dipotassium glycyrrhizinate, aloe juice, squalane, Chuanxiong extract, and Scutellaria extract. Among them, different sunscreen ingredients provide full-band protection for UVA and UVB, have rapid onset and high stability, and are not easily decomposed by ultraviolet rays under long-term exposure; different whitening ingredients whiten through multiple pathways of action, together forming a multi-faceted whitening to achieve a whitening effect; deep moisturizing ingredients with different molecular weights provide deep moisturizing, enhance the skin's water retention and deep moisturizing, effectively enhance the skin's moisturizing ability, reduce water loss after sun exposure, and keep the skin hydrated and refreshed; different anti-irritation ingredients such as bisabolol and dipotassium glycyrrhizinate can soothe and resist irritation, and prevent skin irritation caused by sunscreen; different repair ingredients such as aloe juice and squalane can repair damaged skin after sun exposure; the addition of different plant extracts not only increases the sun protection effect, but also provides better effects in whitening, moisturizing, oil control and repair. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 : Skin condition before and after using Composition 1 sunscreen composition. DETAILED DESCRIPTION

[0027] The present invention is further described below in conjunction with specific embodiments, but the embodiments do not limit the present invention in any form. Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the art.

[0028] The present invention provides a sunscreen composition, the formula and ratio of which are shown in Table 1, and the preparation method thereof comprises the following steps:

[0029] The raw materials and amounts of compositions 1-3 are shown in Table 1, and the amounts are measured in mass percentage.

[0030] Table 1: Compositions of compositions 1-3

[0031]

[0032]

[0033] In the above composition, the preparation method of aloe juice is as follows: peeling aloe leaves, taking aloe leaf pulp, adding 1.5 times the mass of water, squeezing the juice, and obtaining the aloe juice.

[0034] The preparation method of Chuanxiong extract is as follows: take Chuanxiong medicinal material, crush it through a 100-mesh sieve, put it into a subcritical fluid extraction tank, add subcritical fluid butane, the mass ratio of Chuanxiong powder to butane is 1:2, extract 3 times at 50°C, the total extraction time is 50 minutes (the first to third times are 20 minutes, 15 minutes and 15 minutes respectively), separate the extractant butane, recover the Chuanxiong volatile oil, and obtain the Chuanxiong extract.

[0035] The preparation method of Scutellaria baicalensis extract is as follows: Scutellaria baicalensis is taken, crushed and passed through a 100-mesh sieve, placed in a subcritical fluid extraction tank, and subcritical fluid butane is added, the mass ratio of Scutellaria baicalensis powder to butane is 1:2.5, extracted 3 times at 50°C, and the total extraction time is 55 minutes (the first to third times are 25 minutes, 20 minutes and 10 minutes respectively), the extractant butane is separated, and the Scutellaria baicalensis volatile oil is recovered to obtain the Scutellaria baicalensis extract.

[0036] The preparation method of the above composition is as follows:

[0037] Ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine, squalane, cyclopentasiloxane, polydimethylsiloxane, PEG-9 polydimethylsiloxyethyl polydimethicone, isohexadecane, and polyol were heated at 78° C. and stirred at 60 rpm for 0.4 hours to mix to obtain an oil phase;

[0038] Mix water, niacinamide, glabridin, ascorbic acid derivatives, sodium hyaluronate, bisabolol, dipotassium glycyrrhizinate, and disteardimethylammonium hectorite under heating at 45° C. and stirring at 65 rpm for 0.3 hours to obtain an aqueous phase;

[0039] The oil phase was added to the water phase, stirred at 60 rpm for 0.4 hours to mix, cooled to 32° C., and then the remaining raw materials were added, stirred at 60 rpm for 0.3 hours to mix, to obtain a sunscreen composition.

[0040] Composition 4:

[0041] The only difference from composition 1 is that ethylhexyl triazone is not contained and the amount thereof is made up with an equal amount of water.

[0042] Composition 5:

[0043] The only difference from composition 1 is that it does not contain diethylaminohydroxybenzoyl hexyl benzoate, and its amount is made up by an equal amount of water.

[0044] Composition 6:

[0045] The only difference from composition 1 is that bis-ethylhexyloxyphenol methoxyphenyl triazine is not contained and the amount thereof is made up with an equal amount of water.

[0046] Composition 7:

[0047] The only difference from composition 1 is that ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate and bis-ethylhexyloxyphenol methoxyphenyl triazine are not contained, and their amounts are made up with an equal amount of water.

[0048] Composition 8:

[0049] The only difference from composition 1 is that it does not contain Chuanxiong extract and Scutellaria baicalensis extract, and their amounts are made up with an equal amount of water.

[0050] Composition 9:

[0051] The difference from composition 1 is that the preparation methods of Chuanxiong extract and Scutellaria baicalensis extract are different. In the composition, the preparation method of Chuanxiong extract is as follows: take Chuanxiong medicinal material, crush it through a 100-mesh sieve, add 20 times the mass concentration of 65% ethanol, stir at 55°C and 60rpm for 2 hours, concentrate, and freeze-dry at -35°C to a water content of 3.54% to obtain the Chuanxiong extract.

[0052] The preparation method of Scutellaria baicalensis extract is as follows: Scutellaria baicalensis is taken, crushed through a 100-mesh sieve, added with 22 times the mass concentration of 70% ethanol, stirred at 55°C and 60rpm for 2.5 hours, concentrated, and freeze-dried at -37°C to a water content of 3.27% to obtain the Scutellaria baicalensis extract.

[0053] Composition 10:

[0054] The difference from composition 1 is that 1% of Chuanxiong extract and 1.5% of Scutellaria baicalensis extract are replaced by 2.5% of Chuanxiong extract, and the rest are the same as composition 1.

[0055] Composition 11:

[0056] The difference from composition 1 is that 1% of Chuanxiong extract and 1.5% of Scutellaria baicalensis extract are replaced by 2.5% of Scutellaria baicalensis extract, and the rest are the same as composition 1.

[0057] Test Example 1: Sunscreen Effect Test

[0058] The composition and the sample of the composition were concentrated at 2 mg / cm 2 The coating density was evenly coated on the PMMA plate and scanned and tested using an SPF-290S UV spectrophotometer. The SPF values ​​of the test data are shown in Table 2.

[0059] Table 2: Sunscreen effect test

[0060] test SPF value Composition 1 48.9 Composition 2 47.6 Composition 3 48.1 Composition 4 38.3 Composition 5 39.6 Composition 6 37.2 Composition 7 28.5 Composition 8 42.4 Composition 9 45.1 Composition 10 47.0 Composition 11 47.3

[0061] From the data in Table 2, it can be seen that when composition 7 does not contain ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate and bis-ethylhexyloxyphenol methoxyphenyl triazine, its sun protection index is significantly lower than that of the sample of composition 1. However, the sun protection index of compositions 4-6 when not containing one of the three is very poor, indicating that ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate and bis-ethylhexyloxyphenol methoxyphenyl triazine can synergistically enhance the sunscreen effect of the sunscreen composition. From the results of the tests of compositions 8-11, it can be seen that the Chuanxiong extract and the Scutellaria baicalensis extract added in the present invention can enhance the overall sunscreen effect of the composition, and the extraction methods of the Chuanxiong extract and the Scutellaria baicalensis extract have a significant effect on the sunscreen effect enhancement effect, and the combination of the two can also mutually promote the sunscreen effect of the composition to a certain extent.

[0062] Test Example 2: Refreshing and moisturizing effect test

[0063] The refreshing and moisturizing effect test was characterized by testing the skin oil and water content. The specific method is: 42 subjects aged 30 to 45 were randomly selected, including 21 males and 21 females; the subjects were randomly divided into 7 groups, each with 6 people (3 males and 3 females in each group); and they were marked as compositions 1-3 and 8-11 respectively; then the subjects in different groups were asked to use the prepared sunscreen compositions matching their groups, and after 40 minutes of use, the skin oil content and skin water content before and after using the sunscreen compositions were respectively detected using the tester Sebumeter and Corneometer CM825, and the average values ​​of skin water and oil content of each group of volunteers were recorded. The obtained data are recorded in Table 3 below.

[0064] Table 3: Refreshing and moisturizing effect test

[0065]

[0066]

[0067] As can be seen from Table 3, the water content of the skin after using the sunscreen compositions prepared from compositions 1-3 and 8-11 is increased compared to the water content of the skin before use, and the oil content is reduced, and the sunscreen compositions have good moisturizing and refreshing skin effects. Among them, composition 1 has better moisturizing and oil control effects than composition 8 lacking Chuanxiong extract and Scutellaria baicalensis extract, composition 9 prepared by different extraction processes, and compositions 10-11 containing one of Chuanxiong extract or Scutellaria baicalensis extract, indicating that the combination of Chuanxiong and Scutellaria baicalensis and the extraction method have an important influence on the moisturizing and oil control of the composition.

[0068] Test Example 3: UVB-induced photodamage test of HaCaT cells

[0069] The products of compositions 1-3 and 8-11 were freeze-dried and dissolved in MEM complete medium at a concentration of 1 mg / mL. The pH value was adjusted to 7.0, and sterilized by filtration with a 0.22 μm pore size filter membrane. The cells were stored at 4°C and diluted with MEM complete medium to the required concentration (50 μg / mL) for the experiment. HaCaT cells in the logarithmic phase were inoculated in a 96-well plate and cultured in a 37°C, 5% CO2 incubator. After the cells adhered to the wall, they were divided into a normal control group, a model control group, and the compositions 1-3 and 811 of the present invention, with 6 replicates in each group. After 24 hours of culture, 60 mJ / cm 2UVB irradiation, culture for 24 hours. The cell activity was determined by MTT method, 20 μL of 5 mg / mL MTT was added to each well (containing 180 μL culture medium), incubated for 4 hours, supernatant was discarded, 150 μL DMSO was added, and the cells were shaken in a constant temperature culture shaker for 10 minutes. The absorbance value (OD value) of each well at 492 nm was measured by a microplate reader. The results are shown in Table 4.

[0070] Table 4: Absorbance value (OD value)

[0071] Group OD value Normal control group 1.032±0.098 Model control group 0.575±0.063 Composition 1 0.767±0.082 Composition 2 0.756±0.071 Composition 3 0.762±0.078 Composition 8 0.671±0.052 Composition 9 0.702±0.065 Composition 10 0.739±0.080 Composition 11 0.748±0.067

[0072] It can be seen from the data in Table 4 that compared with the normal control group, the cell activity of the model control group decreased significantly, indicating that the modeling was successful. The sample of composition 1 can enhance cell activity, indicating that it can significantly reduce UVB-induced light damage to HaCaT cells, has obvious anti-skin photoaging effects, and therefore has a repairing effect. In contrast, it can also be seen from the results of composition 8 that the Chuanxiong extract and Scutellaria baicalensis extract added in the present invention can enhance the cell activity enhancement effect of the composition, and from the results of composition 9, it can be seen that the extraction method of Chuanxiong extract and Scutellaria baicalensis extract has a significant effect on the cell activity enhancement effect, and from the results of compositions 10-11, it can be seen that the combination of Chuanxiong extract and Scutellaria baicalensis extract obtained by the specific extraction process of the present invention can mutually promote the cell activity enhancement effect of the composition.

[0073] Test Example 4: Whitening and Repair Test

[0074] Six female volunteers aged 20-40 with healthy skin were selected, and the sunscreen composition prepared by composition 1 was applied on the face for 1 month to observe the skin care effect on the facial skin.

[0075] The test showed that the facial skin of the six volunteers became whiter, smoother and more moisturized.

[0076] in, Figure 1 The figure shows the changes in the facial skin of a volunteer before and after using the sunscreen composition of Composition 1. Figure 1 It can be seen that after applying the sunscreen composition prepared by composition 1 on the face for one month, the face will be whitened, repaired and moisturized.

[0077] It should also be noted that, among the various technical features described in the above invention, in the absence of contradiction, they can be modified and combined in any legal manner. In order to avoid unnecessary repetition, the present invention no longer provides descriptions of various possible other proportion combinations. In addition, the various different technical solutions of the present invention can also be combined arbitrarily. As long as they do not violate the central content of the solution of the present invention, they should be equivalent to the content described in the present invention.

Claims

1. A sunscreen composition, characterized in that: Measured in terms of mass percentage, the raw materials include: 0.2%-3.5% of ethylhexyl triazone, 0.2%-5.5% of diethylamino hydroxybenzoyl hexyl benzoate, 0.2%-5.0% of bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.01%-3.0% of niacinamide, 0.00001%-0.1% of glycyrrhizin, 0.01%-0.5% of ascorbic acid derivative, 0.001%-0.2% of sodium hyaluronate, 0.1%-0.3% of bisabolol, 0.001%-0.2% of dipotassium glycyrrhizinate, 0.1%-3.0% of aloe juice, 0.05%-3.0% of squalane, 0.001%-2.0% of chuanxiong extract and 0.001%-2.0% of scutellaria baicalensis extract.

2. The sunscreen composition according to claim 1, characterized in that Calculated in terms of mass percentage, the raw materials include: 1.0% ethylhexyl triazone, 1.5% diethylamino hydroxybenzoyl hexyl benzoate, 1.0% bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.5% niacinamide, 0.002% glabridin, 0.11% ascorbic acid derivative, 0.01% sodium hyaluronate, 0.2% bisabolol, 0.1% dipotassium glycyrrhizinate, 0.9% aloe juice, 0.2% squalane, 1.0% chuanxiong extract and 1.5% scutellaria baicalensis extract.

3. The sunscreen composition according to claim 1 or 2, characterized in that: Calculated by mass percentage, the raw materials also include: 10-16% of cyclopentasiloxane, 4-9% of polydimethylsiloxane, 1.5-6.5% of PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 6-12% of polyol, 0.8-3% of disteardimonium hectorite, 4-6% of isohexadecane, 0-0.5% of preservatives, 0-3% of pigment and the remainder of water.

4. The sunscreen composition according to claim 3, characterized in that The ascorbic acid derivative is 3-o-ethyl ascorbic acid.

5. The sunscreen composition according to claim 3, characterized in that The Chuanxiong extract is prepared as follows: take Chuanxiong, crush and sieve it, put it into a subcritical fluid extraction tank, add subcritical fluid, extract it 2-3 times at 35-55° C., the extraction time is 30-60 minutes, separate the extractant, and recover the Chuanxiong volatile oil to obtain; The scutellaria baicalensis extract is prepared as follows: taking scutellaria baicalensis, crushing and sieving, putting into a subcritical fluid extraction tank, adding subcritical fluid, extracting 2-3 times at 35-55° C., the extraction time is 30-60 minutes, separating the extractant, and recovering scutellaria baicalensis volatile oil to obtain the scutellaria baicalensis extract.

6. The sunscreen composition according to claim 3, characterized in that The polyol includes at least one of glycerol, butylene glycol, ethylene glycol, propylene glycol and hexylene glycol.

7. The sunscreen composition according to claim 3, characterized in that Preservatives include phenoxyethanol.

8. The sunscreen composition according to claim 3, characterized in that Colorants include CI 77891.

9. A method for preparing the sunscreen composition according to any one of claims 3 to 8, characterized in that: The steps include: Ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine, squalane, cyclopentasiloxane, polydimethylsiloxane, PEG-9 polydimethylsiloxyethyl polydimethicone, isohexadecane, and polyol are heated and stirred to obtain an oil phase; Heat and stir water, niacinamide, glabridin, ascorbic acid derivatives, sodium hyaluronate, bisabolol, dipotassium glycyrrhizinate, and disteardimethylammonium hectorite to obtain an aqueous phase; The oil phase is added to the water phase, stirred and mixed, cooled, and then the remaining raw materials are added, stirred and mixed to obtain a sunscreen composition.

10. Use of the sunscreen composition according to any one of claims 1 to 8 in the preparation of sunscreen, whitening, moisturizing, soothing or repairing cosmetics.

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