Pharmaceutical formulations for pressurized metered dose inhalers

CN119630425APending Publication Date: 2025-03-14CHIESI FARMACEUTICI SPA
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Patent Information

Application Number
CN202380042505.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2022-05-27
Filing Date
2023-05-26
Publication Date
2025-03-14

AI Technical Summary

Technical Problem

The prior art has difficulty maintaining chemical stability in aerosol formulations containing LABA agents, especially when combined with corticosteroids, and is difficult to store using commercially available aluminum cans.

Method used

The LABA agent and corticosteroids are stabilized by adding a mixture of acid and chelating agents, such as HCl and EDTANa4, to the formulation, ensuring that the formulation remains stable for a long time and is suitable for aluminum can storage.

Benefits of technology

Chemical stability of LABA agents and corticosteroids is achieved, extending the shelf life of the formulation, and improving the stability characteristics in aluminum cans.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present invention relates generally to pharmaceutical compositions comprising a LABA agent (optionally in combination with other active ingredients), a mixture of an acid and a chelating agent, a propellant and a co-solvent. The present invention also provides pharmaceutical compositions for the treatment of respiratory diseases such as asthma and COPD.
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Citation Information

Patent Citations

  • Stable pharmaceutical solution formulations for pressurised metered dose inhalers

    WO2001089480A1

  • Combination therapy for COPD

    WO2011076843A2

  • Stable pressurised aerosol solution composition of glycopyrronium bromide and formoterol combination

    WO2015101576A1

  • Stable pharmaceutical compositions for pressurized metered dose inhalers

    WO2019236559A1