Device for detecting NO and H2S in oral cavity gas

Abstract

The invention discloses a device for detecting NO and H2S in oral cavity gas, which is applied to the technical field of gas component analysis and detection, and comprises: a gas collection device, which comprises a sampling and filtering module; the filtering module is internally provided with two channels, namely an air suction channel filled with filtering particles and a moisture filtering channel filled with drying particles; the sampling module comprises a connecting part, a collecting part fixedly arranged at one end of the connecting part and a sampling channel penetrating through the collecting part and the connecting part; an air inlet and an air outlet which are communicated with the sampling channel are formed in the connecting part, the air inlet is communicated with the air suction channel, and the air outlet is communicated with the moisture filtering channel; the gas analysis device comprises a gas extraction control module and a detection module, one end of the gas extraction control module is communicated with the moisture filtering channel, and the other end is communicated with the detection module; the detection module comprises a CO2 sensor, an H2S sensor, an NO sensor, a gas filter and a buffer chamber which are connected in series. The component detection precision of the oral cavity gas is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of gas component analysis and detection, and in particular to a device for detecting NO and H2S in oral gas. Background Art

[0002] According to relevant statistics, oral diseases are the most common non-communicable diseases, with an average incidence rate of 45% and an estimated number of cases of nearly 3.5 billion, far higher than other non-communicable diseases. However, oral health has long been neglected in the health field, with low attention and high treatment costs, and is usually not covered by universal health coverage. Therefore, early screening and early diagnosis are particularly important for preventing oral diseases.

[0003] Oral disease detection is mostly carried out by a variety of methods such as oral mirror, X-ray, and CT. Compared with other detection methods, oral gas detection has the characteristics of convenience, high sensitivity, early screening and diagnosis, and early intervention to prevent aggravation. In recent years, it has become a research hotspot as a new diagnostic method. Studies have found that the levels of NO and H2S in the oral cavity are highly correlated with oral diseases. NO and H2S play an important regulatory role in the physiological and pathological processes of the oral mucosa. Among them, oral NO is mainly produced by tissue cell metabolism, mainly by oxidative deamination of cortical cell arginine under the action of NO synthase (iNOS), while oral H2S is mainly produced by bacterial metabolism. The main producing bacteria include Porphyromonas gingivalis, Treponema denticola, Tannerella forsythiae, Clostridium moorei, etc. Inflammation and overgrowth of pathogenic bacteria are two major diagnosable characteristics of oral diseases such as periodontal disease. Therefore, the determination of inflammatory marker NO and bacterial metabolite H2S can be used as potential tools for screening and diagnosis. If the combined detection of oral NO and H2S can be performed, oral inflammation and bacterial metabolism can be better evaluated. The clinical application is not limited to halitosis, but can be extended to the screening or diagnosis of oral diseases such as periodontal disease, so as to intervene in the early stage of the disease and prevent aggravation.

[0004] Existing oral gas detection technology is mainly aimed at the detection of oral H2S and other sulfides for bad breath, such as the Halimeter in the United States and the Oral Chroma instrument in Japan. Oral Chroma uses a syringe to take a small amount of gas sample from the mouth. Although condensation water will not be produced, the sampling sample volume is very small due to the limitation of the chromatographic detection method, and the repeatability is poor. Halimeter uses a mouth-held catheter to extract air for sampling. The catheter is directly connected to the pipeline to enter the instrument for analysis. There is no drying device in the pipeline to dehumidify the extracted oral gas. The water vapor in the oral gas will produce condensation water on the tube wall. Since H2S is very soluble in water, the H2S concentration in the oral gas will be reduced due to the dissolution of H2S in the condensation water, which seriously affects the collection of oral gas and the final detection accuracy. According to statistics, the H2S concentration results tested by Halimeter are 1-2 times smaller than those of Oral Chroma. Patent CN117618031A also discloses an oral gas detection device, but does not disclose a solution to the impact of oral gas condensation water on sampling and testing.

[0005] In addition, due to the particularity of oral flora, in addition to producing NO and H2S, there are also various producing bacteria, such as caries-related bacteria: Streptococcus mutans, Lactobacillus acidophilus and Propionibacterium acidophilus, the compounds produced include: cyclohexanone, pentanone, octanal and dimethyl sulfide. Saliva-related bacteria: Klebsiella pneumoniae and Staphylococcus saccharolyticus, the compounds produced include: short-chain and medium-chain fatty acids, such as acetic acid and butyric acid, and S-methylpentyl sulfate. Microorganisms from tongue coating, especially anaerobic bacteria associated with the tongue surface, produce compounds including: indole, ammonia and methyl methacrylate. Subgingival anaerobic bacteria: Treponema dentalis, Prevotella intermedia, Prevotella nigra and Forsellella, the compounds produced include: methyl mercaptan, dimethyl disulfide and methanol. The above compounds may interfere with the detection of NO and H2S, affecting the accuracy of the test results.

[0006] Therefore, how to provide a detection device for NO and H2S in oral gas that can effectively avoid the influence of oral gas condensation on sampling and testing and the influence of various microorganisms produced by oral flora on test results, and effectively improve the detection accuracy of NO and H2S in oral gas is a problem that technical personnel in this field urgently need to solve. Summary of the invention

[0007] In view of this, the present invention proposes a device for detecting NO and H2S in oral gas.

[0008] In order to achieve the above object, the present invention adopts the following technical solution:

[0009] A device for detecting NO and H2S in oral gas, comprising: a gas collection device and a gas analysis device;

[0010] The gas collection device comprises: a sampling module and a filtering module;

[0011] There are two channels in the filter module, namely the air intake channel and the moisture filtering channel;

[0012] The air intake channel is filled with filter particles, and the wet filter channel is filled with dry particles;

[0013] The sampling module includes a connecting part, a collecting part fixed at one end of the connecting part, and a sampling channel penetrating the collecting part and the connecting part; the collecting part is placed in the oral cavity;

[0014] The connecting part is provided with an air inlet and an air outlet which are connected to the sampling channel, the air inlet is connected to the air suction channel of the filter module, and the air outlet is connected to the moisture filtering channel of the filter module;

[0015] A gas analysis device, comprising: a gas extraction control module and a detection module;

[0016] One end of the gas extraction control module is connected to the moisture filtering channel of the filter module, and the other end is connected and connected to the detection module;

[0017] The detection module includes: a CO2 sensor, a H2S sensor, a NO sensor, a gas filter and a buffer chamber connected in series;

[0018] A gas extraction control module, including: a sampling pump and a four-way control valve;

[0019] The sampling pump draws ambient air through the suction channel of the filter module into the sampling channel and the oral cavity. The oral gas then passes through the sampling channel and the moisture filter channel into the CO2 sensor, H2S sensor, and NO sensor for measurement, and enters the buffer chamber through the gas filter. The state of the four-way control valve is switched so that the sampling pump draws the filtered gas in the buffer chamber and passes it into the CO2 sensor, H2S sensor, and NO sensor for measurement. The concentration data of the component to be measured is calculated by the corresponding current difference of the oral gas before and after filtration.

[0020] Optionally, the sampling module is a detachable, disposable product.

[0021] Optionally, the filter particles are aluminum oxide particles loaded with potassium permanganate particles or platinum black.

[0022] Optionally, the dry particles are plant fiber or glass fiber particles loaded with anhydrous calcium chloride or anhydrous magnesium sulfate.

[0023] Optionally, the preparation process of the dry particles is to mix anhydrous calcium chloride or anhydrous magnesium sulfate with plant fiber or glass fiber slurry in a preset ratio, granulate the granules, and then place the granules in an oven for drying.

[0024] Optionally, at least one diffusion hole is provided on the collecting portion.

[0025] Optionally, the gas extraction control module can control the gas extraction flow rate according to different needs.

[0026] It can be seen from the above technical solutions that, compared with the prior art, the present invention proposes a detection device for NO and H2S in oral gas. By setting an air intake channel filled with filter particles on the ambient air delivery path, setting a moisture filter channel filled with dry particles on the oral gas return path, and integrating the two channels in a filter module, not only the components interfering with the detection in the ambient air are removed, the extracted oral gas is dried, and the generation of condensed water is avoided, and the components to be detected are not adsorbed, and the interfering substances that affect the detection of the components to be detected are not released, which effectively improves the detection accuracy of NO and H2S in oral gas, and compared with the existing collection equipment, a simpler structure and lower cost are achieved. By splitting the sampling module and the filtering module, the sampling module that directly contacts the cavity is designed as a disposable item, which not only avoids cross infection, but also effectively reduces the consumables cost of the equipment. By adopting a dry particle production process of mixing the slurry first and then granulating and drying, it is simpler than the existing process, and the produced dry particles have a higher moisture absorption rate, which can reach 100% of their own weight, and achieves good moisture absorption efficiency and high moisture absorption stability, and a longer service life. By using the buffer chamber to synchronously collect filtered gas while measuring oral gas, only the filtered gas needs to be measured later. The overall sampling and analysis time is shortened by at least 50% compared with the traditional method of sampling first and then analyzing, which is suitable for multiple uses and rapid detection needs in clinical diagnosis. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0028] Figure 1 It is a schematic diagram of the device structure of the present invention.

[0029] Figure 2 It is a schematic diagram of the physical structure of the gas collection device of the present invention.

[0030] 1-sampling module, 2-filtering module, 11-connecting part, 12-collecting part, 13-sampling channel, 121-diffusion hole, 21-inhalation channel, 22-wet filter channel. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0032] Embodiment 1:

[0033] Embodiment 1 of the present invention discloses a device for detecting NO and H2S in oral gas, such as Figure 1 As shown, it includes: a gas collection device and a gas analysis device;

[0034] Gas collection devices, such as Figure 2 As shown, it includes: a sampling module 1 and a filtering module 2;

[0035] The filter module 2 has two channels, namely the air intake channel 21 and the moisture filter channel 22, which are integrally formed, simple in structure, easy to assemble, and lower in cost;

[0036] The air inlet channel 21 is filled with filter particles, which can filter out the interfering components to be detected in the ambient air, and is used to supply ambient air that does not interfere with the components to be detected, eliminating the influence of the environment on the detection results. The moisture filter channel 22 is filled with drying particles, which is used to dry the extracted oral gas, avoiding the generation of condensed water, and will not adsorb the components to be detected, nor release interfering substances that affect the detection of the components to be detected;

[0037] The sampling module 1 includes a connecting portion 11, a collecting portion 12 fixed to one end of the connecting portion 11, and a sampling channel 13 penetrating the collecting portion 12 and the connecting portion 11; the collecting portion 12 is placed in the oral cavity;

[0038] The connecting portion 11 is provided with an air inlet and an air outlet connected to the sampling channel 13, the air inlet is connected to the air suction channel 21 of the filter module 2, and the air outlet is connected to the moisture filtering channel 22 of the filter module 2;

[0039] A gas analysis device, comprising: a gas extraction control module and a detection module;

[0040] One end of the gas extraction control module is connected to the moisture filtering channel 22 of the filter module 2, and the other end is connected and connected to the detection module;

[0041] The detection module includes: a CO2 sensor, an H2S sensor, an NO sensor, a gas filter and a buffer chamber connected in series; in addition, sensors corresponding to detecting other components can be added according to other actual detection needs.

[0042] A gas extraction control module, including: a sampling pump and a four-way control valve;

[0043] The sampling pump draws ambient air through the suction channel 21 of the filter module 2 into the sampling channel 13 and the oral cavity. The oral gas then passes through the sampling channel 13 and the moisture filter channel 22 to enter the CO2 sensor, H2S sensor, and NO sensor for measurement, and enters the buffer chamber through the gas filter (at this time, the gas in the original buffer chamber is discharged through the four-way valve). The present invention uses the buffer chamber to synchronously collect the filtered gas while measuring the oral gas, so that only the filtered gas needs to be measured later. The overall sampling and analysis time is shortened by at least 50% compared with the traditional method of sampling first and then analyzing, which is suitable for multiple uses and rapid detection requirements in clinical diagnosis; the state of the four-way control valve is switched to allow the sampling pump to extract the filtered gas in the buffer chamber, pass it into the CO2 sensor, H2S sensor, and NO sensor for measurement, and calculate the concentration data of the component to be measured by the corresponding current difference of the oral gas before and after filtration. Calculating gas component concentration data based on current difference belongs to the prior art in this field and will not be repeated here.

[0044] The sampling pump flow rate is set to 5ml / s, the buffer gas chamber volume is 50ml, the sampling time is 10s, the analysis time is 10s, the oral breath is analyzed simultaneously during sampling, and the filtered oral breath is stored in the buffer chamber. After sampling, only the filtered oral breath needs to be analyzed again. The overall sampling and analysis time is shortened by at least 50% compared with the traditional method of sampling first and then analyzing.

[0045] Optionally, the sampling module 1 is a detachable disposable product, which can effectively avoid cross infection. The filtering module 2 does not contact the oral cavity and can be used multiple times. This split design not only avoids the risk of cross infection, but also reduces the cost of consumables of the equipment and is also conducive to reducing the difficulty of assembly.

[0046] Optionally, the filter particles are aluminum oxide particles loaded with potassium permanganate particles or platinum black.

[0047] Aluminum oxide particles loaded with potassium permanganate, with a particle size of 0.5-1.5 mm, can remove nitric oxide, hydrogen sulfide, methyl mercaptan, methanol, acetaldehyde, ethanol, ether, ethyl acetate, isobutanol, etc.

[0048] Alumina particles loaded with platinum black can remove carbon monoxide, nitrogen oxides, hydrogen sulfide, etc.

[0049] Both filter particles can completely filter NO and H2S, meeting the requirements for ambient air filtration.

[0050] Optionally, the dry particles are plant fiber or glass fiber particles loaded with anhydrous calcium chloride or anhydrous magnesium sulfate.

[0051] When selecting the filter material, various materials are considered. Silica gel particles and molecular sieve particles can absorb H2S, and the absorption rate of 60ppbH2S is 30-50% and 70-90%. Anhydrous calcium chloride or anhydrous magnesium sulfate has a strong drying ability, will not adsorb the components to be detected, and will not release interfering substances that affect the detection of the components to be detected. Loading them on plant fibers or glass fibers can further improve the moisture absorption efficiency.

[0052] Optionally, the preparation process of the dry particles is to mix anhydrous calcium chloride or anhydrous magnesium sulfate with plant fiber or glass fiber slurry in a preset ratio (the preset ratio in the present invention is 1:3), granulate and then place in an oven for drying. The preparation process of first mixing the slurry and then granulating and drying is simpler than the existing process. The produced dry particles have a higher moisture absorption rate, which can reach 100% of their own weight, good moisture absorption efficiency and high moisture absorption stability, and a longer service life.

[0053] Optionally, at least one diffusion hole 121 is provided on the collection portion 12 , and oral gas passes through the diffusion hole 121 , and enters the gas analysis device via the sampling channel 13 and the moisture filtering channel 22 .

[0054] Optionally, the gas extraction control module can control the gas extraction flow rate according to different needs.

[0055] The embodiment of the present invention discloses a detection device for NO and H2S in oral gas. By setting an air intake channel filled with filter particles on the ambient air delivery path, setting a moisture filter channel filled with dry particles on the oral gas return path, and integrating the two channels into a filter module, not only the components interfering with the detection in the ambient air are removed, the extracted oral gas is dried, and the generation of condensed water is avoided, and the components to be detected are not adsorbed, and the interfering substances that affect the detection of the components to be detected are not released, the detection accuracy of NO and H2S in oral gas is effectively improved, and a simpler structure and lower cost are achieved compared with the existing collection equipment. By designing the sampling module and the filtering module separately, the sampling module that directly contacts the cavity is designed as a disposable item, which not only avoids cross infection, but also effectively reduces the consumables cost of the equipment. By adopting a dry particle manufacturing process of mixing the slurry first and then granulating and drying, it is simpler than the existing process, and the manufactured dry particles have a higher moisture absorption rate, which can reach 100% of their own weight, and achieve good moisture absorption efficiency and high moisture absorption stability, and a longer service life. By using the buffer chamber to synchronously collect filtered gas while measuring oral gas, only the filtered gas needs to be measured later. The overall sampling and analysis time is shortened by at least 50% compared with the traditional method of sampling first and then analyzing, which is suitable for multiple uses and rapid detection needs in clinical diagnosis.

[0056] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.

[0057] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A device for detecting NO and H2S in oral gas, characterized in that: include: Gas collection devices and gas analysis devices; The gas collection device comprises: a sampling module 1 and a filtering module 2; The filter module is provided with two channels, namely an air intake channel 21 and a moisture filtering channel 22; The air intake channel 21 is filled with filter particles, and the moisture filter channel 22 is filled with dry particles; The sampling module 1 comprises a connecting portion 11, a collecting portion 12 fixed to one end of the connecting portion 11, and a sampling channel 13 running through the collecting portion 12 and the connecting portion 11; the collecting portion 12 is placed in the oral cavity; The connecting portion 11 is provided with an air inlet and an air outlet connected to the sampling channel 13, the air inlet is connected to the air suction channel 21 of the filter module 2, and the air outlet is connected to the moisture filtering channel 22 of the filter module 2; The gas analysis device comprises: a gas extraction control module and a detection module; One end of the gas extraction control module is connected to the moisture filtering channel 22 of the filter module 2, and the other end is connected and connected to the detection module; The detection module includes: a CO2 sensor, an H2S sensor, an NO sensor, a gas filter and a buffer chamber connected in series; The gas extraction control module includes: a sampling pump and a four-way control valve; The sampling pump draws ambient air through the air intake channel 21 of the filter module 2 into the sampling channel 13 and the oral cavity. The oral gas then passes through the sampling channel 13 and the moisture filter channel 22 to enter the CO2 sensor, H2S sensor, and NO sensor for measurement, and enters the buffer chamber through the gas filter. The state of the four-way control valve is switched so that the sampling pump draws the filtered gas in the buffer chamber and passes it into the CO2 sensor, H2S sensor, and NO sensor for measurement. The concentration data of the component to be measured is calculated by the corresponding current difference of the oral gas before and after filtration.

2. A device for detecting NO and H2S in oral gas according to claim 1, characterized in that: The sampling module 1 is a detachable disposable product.

3. The device for detecting NO and H2S in oral gas according to claim 1, characterized in that: The filter particles are aluminum oxide particles loaded with potassium permanganate particles or platinum black.

4. The device for detecting NO and H2S in oral gas according to claim 1, characterized in that: The dry particles are plant fiber or glass fiber particles loaded with anhydrous calcium chloride or anhydrous magnesium sulfate.

5. The device for detecting NO and H2S in oral gas according to claim 4, characterized in that: The preparation process of the dry particles is to mix anhydrous calcium chloride or anhydrous magnesium sulfate with plant fiber or glass fiber slurry in a preset ratio, granulate and place in an oven for drying.

6. The device for detecting NO and H2S in oral gas according to claim 1, characterized in that: The collecting portion 12 is provided with at least one diffusion hole 121 .

7. The device for detecting NO and H2S in oral gas according to claim 1, characterized in that: The gas extraction control module can control the gas extraction flow rate according to different needs.

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