Intrathecal injection dosing tool for experimental animals

Abstract

The invention relates to the technical field of medical instruments for experimental animals, and discloses an intrathecal injection dosing tool for experimental animals. The fixing device is arranged on the outer side of the needle seat; the push rod is movably connected into the needle seat; the end, away from the push rod, of the needle base is fixedly connected with the protective sleeve. The injection needle penetrates through the protective sleeve and is in sliding connection with the protective sleeve; the depth adjusting assembly is arranged in the protective sleeve, the fixing device and the depth adjusting assembly are provided, the injection needle can be more accurately inserted into the intrathecal space of the macaque, meanwhile, the adjustable fixing device and the depth adjusting assembly can adapt to macaque of different body types and ages, the universality and practicability of the tool are improved, and the tool is convenient to use. The needle base is provided with the measuring meter and the matched injector, the injection dosage of medicine can be more accurately controlled, the strict requirements of experiments for the medicine concentration and dosage are met, and the accuracy and reliability of experiment results are improved.

Description

Technical Field

[0001] The invention relates to the technical field of medical instruments for experimental animals, in particular to an intrathecal injection drug delivery tool for experimental animals. Background Art

[0002] In many research fields such as neuroscience and pharmacology, it is often necessary to administer drugs via intrathecal injection to macaques to study the mechanism of action and efficacy of drugs in the nervous system.

[0003] At present, some traditional injection needles have poor adaptability to the spinal structure of macaques, making it difficult to accurately inject drugs into the intrathecal space, resulting in a low injection success rate. At the same time, during the operation, the macaque's spinal cord may be damaged due to instability or improper operation of the tool, affecting the accuracy of the experimental results and the health of the macaque. In addition, some existing tools are not precise enough in controlling the dosage and cannot meet the strict requirements of the experiment for drug concentration and dosage.

[0004] In view of the above problems, an intrathecal injection drug delivery tool for experimental animals is proposed. Summary of the invention

[0005] The purpose of the present invention is to provide an intrathecal injection drug delivery tool for experimental animals, which solves the problems in the background technology that the injection needle is difficult to accurately inject, the drug dosage is controlled, and the tool is unstable.

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a needle seat; a fixing device, a fixing device is provided on the outer side of the needle seat; a push rod, which is movably connected to the push rod inside the needle seat; a protective sleeve, and the end of the needle seat away from the push rod is fixedly connected to the protective sleeve; an injection needle, the injection needle penetrates the protective sleeve and is slidably connected to the protective sleeve; the fixing device comprises a positioning plate, a first fixing block, a groove, a double-headed motor, a screw rod, a screw rod slider, a limit plate and an arc limit block, the outer wall of the needle seat is detachably connected to a fixing belt, the fixing belt is fixedly connected to the first fixing block, the first fixing block is fixedly connected to the positioning plate at a side away from the fixing belt, the positioning plate is provided with a groove on one side, the double-headed motor is fixedly connected to the inside of the groove, the output shafts of the double-headed motor are fixedly connected to the screw rod, the end of the screw rod away from the double-headed motor is rotatably connected to the inner wall of the groove, the outer wall of the screw rod is threadedly connected to the screw rod slider, the outer side of the screw rod slider is fixedly connected to the limit plate, and the opposite sides of the two limit plates are fixedly connected to the arc limit blocks.

[0007] As a further description of the above technical solution: a depth adjustment assembly is provided inside the protective sleeve, and the depth adjustment assembly includes a gear, a rack, a first shaft rod, a fixing assembly, a second shaft rod, a first bevel gear and a second bevel gear. The outer side of the needle seat is rotatably connected to the second shaft rod through the fixing assembly, and the end of the second shaft rod away from the needle seat is fixedly connected to the first bevel gear, the outer side wall of the injection needle is fixedly connected to the rack, a rotating hole is provided on the outer side wall of the protective sleeve, and the first shaft rod is rotatably connected in the rotating hole, the end of the first shaft rod located inside the protective sleeve is fixedly connected to the gear, the gear and the rack are meshingly connected, the end of the first shaft rod away from the gear passes through the protective sleeve and is fixedly connected to the second bevel gear, and the first bevel gear and the second bevel gear are meshingly connected.

[0008] As a further description of the above technical solution: the injection needle is connected to the needle seat through a water pipe, and the water pipe is a telescopic water pipe.

[0009] As a further description of the above technical solution: a rotating button is fixed to one end of the second shaft rod close to the needle seat, and the surface of the rotating button is integrally formed with angle stripes.

[0010] As a further description of the above technical solution: an anti-skid pad is fixedly connected to the outer side wall of the second shaft rod, and the outer side of the anti-skid pad is in contact with the inner side wall of the fixed component.

[0011] As a further description of the above technical solution: one end of the push rod away from the needle seat is fixedly connected to a handle made of selenium glue with a surface that increases friction.

[0012] As a further description of the above technical solution: a scale for observing the depth is engraved on the outer wall of the injection needle.

[0013] As a further description of the above technical solution: the shape of the arc-shaped limit block is an elliptical limit block that increases the contact area, and a rubber strip that contacts the animal's skin is fixedly connected to one side of the arc-shaped limit block.

[0014] Compared with the prior art, the present invention has the following beneficial effects:

[0015] 1. The fixing device and depth adjustment assembly provided by the present invention can more accurately insert the injection needle into the intrathecal space of the macaque, reducing experimental failure and drug waste caused by inaccurate injection position. The stabilizing effect of the fixing device and the reasonable design of the injection needle reduce the risk of damage to the spinal cord of the macaque during the injection process, ensuring the health of the macaque and the smooth progress of the experiment. At the same time, the operation of the tool is simpler, reducing the probability of operator error. The adjustable fixing device and depth adjustment assembly can adapt to macaques of different sizes and ages, improving the versatility and practicality of the tool.

[0016] 2. The present invention provides a needle holder and a needle tube with a measuring scale and a matching syringe. This tool can more accurately control the injection dose of the drug, meet the strict requirements of the experiment on drug concentration and dosage, and improve the accuracy and reliability of the experimental results. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention;

[0018] Figure 2 It is a schematic diagram of the structure of the fixing device in the present invention;

[0019] Figure 3 For the present invention Figure 2 A schematic diagram of the enlarged structure at point A;

[0020] Figure 4 It is a schematic diagram of the structure of the depth adjustment component in the present invention;

[0021] Figure 5 For the present invention Figure 4 Schematic diagram of the enlarged structure at B.

[0022] In the figure: 1. needle seat; 2. handle; 3. fixing device; 301. positioning plate; 302. first fixing block; 303. groove; 304. double-headed motor; 305. screw; 306. screw slider; 307. limit plate; 308. arc limit block; 309. rubber strip; 4. depth adjustment component; 401. gear; 402. rack; 403. first shaft rod; 404. fixing component; 405. rotating button; 406. second shaft rod; 407. first bevel gear; 408. second bevel gear; 409. angle stripes; 5. water pipe; 6. push rod; 7. protective cover; 8. fixing belt; 9. injection needle; 10. rotating hole. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0024] In order to further understand the content of the present invention, the present invention is described in detail in conjunction with the accompanying drawings.

[0025] Combination Figure 1 , Figure 2 and Figure 3, needle seat 1; fixing device 3, a fixing device 3 is provided on the outside of the needle seat 1; a push rod 6, the push rod 6 is movably connected inside the needle seat 1; a protective sleeve 7, the end of the needle seat 1 away from the push rod 6 is fixedly connected to the protective sleeve 7; an injection needle 9, the injection needle 9 passes through the protective sleeve 7 and is slidably connected to the protective sleeve 7; the fixing device 3 includes a positioning plate 301, a first fixing block 302, a groove 303, a double-headed motor 304, a screw 305, a screw slider 306, a limit plate 307 and an arc-shaped limit block 308, the outer wall of the needle seat 1 is detachably connected with a fixing belt 8, the needle seat 1 is made of high-strength plastic transparent material and has a scale, the fixing belt 8 is fixedly connected to the first fixing block 302, and the first fixing block 302 is fixedly connected to the positioning plate 301 on the side away from the fixing belt 8, the positioning plate 3 A groove 303 is provided on one side of 01, and a double-headed motor 304 is fixedly connected inside the groove 303. The double-headed motor 304 drives two separate output shafts to make the output more accurate and stable. The output shafts of the double-headed motor 304 are fixedly connected to the screw rod 305. The end of the screw rod 305 away from the double-headed motor 304 is rotatably connected to the inner wall of the groove 303. The outer wall of the screw rod 305 is threadedly connected to a screw slider 306. The rotation of the screw rod 305 drives the screw slider 306 to move. The outer side of the screw slider 306 is fixedly connected to a limit plate 307. The opposite sides of the two limit plates 307 are fixedly connected to an arc limit block 308. The shape of the arc limit block 308 is an elliptical limit block that increases the contact area, so that the outer side of the screw slider 306 fixedly connected to the limit plate 307 can better fit the animal skin;

[0026] The double-headed motor 304 fixed inside the groove 303 drives the screw rod 305 to rotate, and the rotation of the screw rod 305 drives the screw rod slider 306. The movement of the screw rod slider 306 drives the limit plate 307 and the arc limit block 308 to move, which better fits the macaque skin and fixes the macaque spine.

[0027] Combination Figure 1 , Figure 4 and Figure 5The protective sleeve 7 is provided with a depth adjustment component 4 inside, and the depth adjustment component 4 includes a gear 401, a rack 402, a first shaft rod 403, a fixing component 404, a second shaft rod 406, a first bevel gear 407 and a second bevel gear 408. The outer side of the needle seat 1 is rotatably connected to the second shaft rod 406 through the fixing component 404, and the end of the second shaft rod 406 away from the needle seat 1 is fixedly connected to the first bevel gear 407, and the outer wall of the injection needle 9 is fixedly connected to the rack 402. The outer wall of the protective sleeve 7 is provided with a rotating hole 10, and the first shaft rod 403 is rotatably connected in the rotating hole 10. The end of the first shaft rod 403 located inside the protective sleeve 7 is fixedly connected to the gear 401, and the gear 401 The first shaft 403 is meshed with the gear 401, and the end of the first shaft 403 away from the gear 401 passes through the protective cover 7 and is fixedly connected with the second bevel gear 408. The first bevel gear 407 and the second bevel gear 408 are meshed with each other. The rotation of the second shaft 406 drives the rotation of the first bevel gear 407. The first bevel gear 407 and the second bevel gear 408 are meshed with each other, prompting the second bevel gear 408 to rotate. The rotation of the second bevel gear 408 rotates the gear 401 through the first shaft 403. The gear 401 and the rack 402 are meshed with each other, thereby adjusting the size of the injection needle 9. The injection needle 9 is made of a special material with suitable hardness and flexibility to adapt to the physiological curvature of the spine of the macaque.

[0028] Combination Figure 1 , Figure 2 and Figure 4 The end of the push rod 6 away from the needle seat 1 is fixedly connected to a handle 2 made of selenium glue with increased friction on the surface, so as to increase the friction between the hand and the handle 2 and prevent the tool from slipping during the injection process. A rubber strip 309 in contact with the animal skin is fixedly connected to one side of the arc-shaped limit block 308. The injection needle 9 is connected to the needle seat 1 through a water pipe 5, and the water pipe 5 is a telescopic water pipe 5. A scale for observing the depth is engraved on the outer wall of the injection needle 9. A rotating button 405 is fixed to the end of the second shaft rod 406 close to the needle seat 1. An angle stripe 409 is integrally formed on the surface of the rotating button 405. The insertion depth of the injection needle 9 and the dosage of the medicine can be accurately adjusted through precise scale markings and adjustment knobs. An anti-skid pad is fixedly connected to the outer wall of the second shaft rod 406, and the outer side of the anti-skid pad contacts the inner wall of the fixed component 404.

[0029] Working principle: When performing intrathecal injection, first correctly install the fixing device 3 on the spine of the macaque, and adjust the positions of the arc-shaped limit block 308 and the rubber strip 309 of the fixing device 3 to make it fit closely to the spine of the macaque, so as to ensure the stability of the tool during the injection process;

[0030] Then, according to the specific situation of the macaque, the depth adjustment component 4 is used to set the appropriate dosage of the medicine and the insertion depth of the injection needle 9. The operator holds the needle holder 1 and slowly inserts the injection needle 9 into the spinal space of the animal along a predetermined direction. During the insertion process, the operator ensures that the injection needle 9 reaches the predetermined depth by observing the scale changes of the depth adjustment component 4.

[0031] After the final injection is completed, the injection needle 9 is slowly pulled out and the fixing device 3 is removed from the macaque.

[0032] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A drug delivery tool for intrathecal injection of experimental animals, characterized in that: include: Needle holder (1); A fixing device (3), wherein the outer side of the needle seat (1) is provided with a fixing device (3); A push rod (6), the needle seat (1) is internally movably connected to the push rod (6); A protective sleeve (7), an end of the needle seat (1) away from the push rod (6) being fixedly connected to the protective sleeve (7); An injection needle (9), the injection needle (9) penetrates the protective sleeve (7) and is slidably connected to the protective sleeve (7); The fixing device (3) comprises a positioning plate (301), a first fixing block (302), a groove (303), a double-headed motor (304), a screw (305), a screw slider (306), a limiting plate (307) and an arc-shaped limiting block (308); the outer wall of the needle seat (1) is detachably connected with a fixing belt (8); the fixing belt (8) is fixedly connected with the first fixing block (302); the first fixing block (302) is fixedly connected with the positioning plate (301) on a side away from the fixing belt (8); the positioning plate (301) A groove (303) is provided on one side, a double-headed motor (304) is fixedly connected inside the groove (303), the output shaft of the double-headed motor (304) is fixedly connected to a screw rod (305), one end of the screw rod (305) away from the double-headed motor (304) is rotatably connected to the inner wall of the groove (303), a screw rod slider (306) is threadedly connected to the outer wall of the screw rod (305), the outer side of the screw rod slider (306) is fixedly connected to a limit plate (307), and the opposite sides of the two limit plates (307) are fixedly connected to arc-shaped limit blocks (308).

2. The intrathecal injection drug delivery tool for experimental animals according to claim 1, characterized in that: The protective sleeve (7) is provided with a depth adjustment assembly (4) inside, and the depth adjustment assembly (4) includes a gear (401), a rack (402), a first shaft (403), a fixing assembly (404), a second shaft (406), a first bevel gear (407) and a second bevel gear (408). The outer side of the needle seat (1) is rotatably connected to the second shaft (406) through the fixing assembly (404), and the end of the second shaft (406) away from the needle seat (1) is fixedly connected to the first bevel gear (407). The outer wall of the injection needle (9) is fixedly connected to the second shaft (406). A rack (402) is fixedly connected, a rotating hole (10) is opened on the outer wall of the protective sleeve (7), a first shaft (403) is rotatably connected in the rotating hole (10), one end of the first shaft (403) located inside the protective sleeve (7) is fixedly connected to a gear (401), the gear (401) and the rack (402) are meshingly connected, one end of the first shaft (403) away from the gear (401) passes through the protective sleeve (7) and is fixedly connected to a second bevel gear (408), and the first bevel gear (407) and the second bevel gear (408) are meshingly connected.

3. The intrathecal injection drug delivery tool for experimental animals according to claim 1, characterized in that: The injection needle (9) is connected to the needle seat (1) via a water pipe (5), and the water pipe (5) is a telescopic water pipe (5).

4. The intrathecal injection drug delivery tool for experimental animals according to claim 1, characterized in that: A rotation button (405) is fixed to one end of the second shaft (406) close to the needle seat (1), and the surface of the rotation button (405) is integrally formed with angle stripes (409).

5. The intrathecal injection drug delivery tool for experimental animals according to claim 1, characterized in that: An anti-skid pad is fixedly connected to the outer side wall of the second shaft rod (406), and the outer side of the anti-skid pad is in contact with the inner side wall of the fixing component (404).

6. The intrathecal injection drug delivery tool for experimental animals according to claim 1, characterized in that: The end of the push rod (6) away from the needle seat (1) is fixedly connected to a handle (2) made of selenium rubber material with a surface that increases friction.

7. The intrathecal injection drug delivery tool for experimental animals according to claim 1, characterized in that: The outer wall of the injection needle (9) is engraved with a scale for observing the depth.

8. The intrathecal injection drug delivery tool for experimental animals according to claim 1, characterized in that: The shape of the arc-shaped limit block (308) is an elliptical limit block for increasing the contact area, and a rubber strip (309) for contacting the animal's skin is fixedly connected to one side of the arc-shaped limit block (308).

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