Liquid path system for chemiluminescence immunoassay analyzer

Abstract

The invention discloses a liquid path system for a chemiluminescence immunoassay analyzer. The liquid path system comprises a purified water feeding module, a waste liquid container, a proportioning module, a magnetic washing module, a sample filling module, a reagent filling module, a substrate unit, a reagent disc circulating cooling unit and a waste sample treatment unit, the magnetic washing module, the sample filling module, the reagent filling module and the substrate unit are all connected with the waste liquid container, and the proportioning module, the magnetic washing module, the sample filling module, the reagent filling module and the substrate unit are all connected with the purified water feeding module; the sample filling module comprises a degassing unit for degassing purified water, a sample filling unit, a first cleaning unit and an alkali liquor cleaning unit. The degassing unit is additionally arranged on the sample filling module, oxygen separated out of water is removed through the degassing unit, and purified water enters the system after being degassed through the degassing unit; alkali liquor cleaning is added on the basis of traditional washing, water cleaning and alkali liquor cleaning are combined, and the cleaning effect of the sample needle is greatly guaranteed.

Description

Technical Field

[0001] The invention relates to the field of liquid circuits of immunoassay equipment, and in particular to a liquid circuit system for a chemiluminescent immunoassay analyzer. Background Art

[0002] The liquid circuit system is the core execution module for in vitro diagnostic equipment to achieve precise quantitative detection and stable operation. Its stability and accuracy also determine the repeatability of samples. The liquid circuit system of existing chemiluminescence analyzers mainly includes a sample needle / reagent needle module, a substrate module, a magnetic bead injection unit, a sample needle and a reagent needle injection unit, and a waste liquid treatment module. These modules are used to achieve sample sampling / injection, reagent sampling / injection, substrate sampling / injection, magnetic bead washing solution injection / waste discharge, sample needle and reagent needle cleaning, cleaning mechanism waste liquid treatment, overall liquid circuit system, pipeline maintenance and treatment, etc.

[0003] At present, the sample injection and reagent addition of the liquid circuit system of the existing chemiluminescence immunoassay instrument usually share the same injection needle and injection pump, which affects the detection throughput of the instrument and has a high probability of cross-contamination. In addition, the bubbles in the water during the cleaning process affect the stability of the system. In addition, there is a risk of liquid overflow in the reaction cup during cleaning of the existing magnetic bead injection unit, further affecting the stability of the system. Furthermore, the detection flux of the existing chemiluminescence immunoassay instrument is generally low, and the corresponding liquid circuit system cannot achieve high-throughput detection. Summary of the invention

[0004] In view of this, the present invention proposes a liquid path system for a chemiluminescent immunoassay analyzer.

[0005] To achieve the above object, the present invention adopts the following technical solutions: The liquid circuit system for a chemiluminescent immunoassay analyzer of the present invention comprises a purified water supply module, a waste liquid container for containing waste liquid, a proportioning module, a magnetic washing module for washing magnetic beads in a reaction cup, a sample filling module, a reagent filling module and a substrate unit. The liquid circuit system also comprises a reagent disk circulation cooling unit and a waste sample processing unit; the magnetic washing module, the sample filling module, the reagent filling module and the substrate unit are all connected to the waste liquid container, and the proportioning module, the magnetic washing module, the sample filling module, the reagent filling module and the substrate unit are all connected to the purified water supply module; the sample filling module comprises a degassing unit for degassing purified water, a sample filling unit and a first cleaning unit and an alkali liquid cleaning unit for cleaning the sample filling unit; the proportioning module comprises an alkali liquid proportioning unit for providing alkali liquid to the alkali liquid cleaning unit and a washing liquid proportioning unit for providing magnetic washing washing liquid to the magnetic washing module.

[0006] The beneficial effects are as follows: the sample filling module of the present invention has a newly added degassing unit, which is used to remove oxygen precipitated from the water, and the purified water is degassed by the degassing unit before entering the system; the present invention has added an alkaline solution cleaning on the basis of traditional water washing, and the alkaline solution can be used to soak the sample needle inside and outside and reciprocately suck and clean it, combining water cleaning and alkaline solution cleaning to greatly ensure the cleaning effect of the sample needle. In actual installation, the sample filling unit is at least two or more groups, which effectively improves the detection efficiency.

[0007] In a preferred embodiment of the present invention, the purified water supply module has a water supply pipeline, a first container and a second container connected to the water supply pipeline; the degassing unit includes a pure water pump, a heater and a degassing device connected in sequence through pipelines, and also includes a pressure regulating pipeline connected to the degassing device, the pressure regulating pipeline is connected to the second container, and the second container is connected to the first container through a reflux pipeline, and the pressure regulating pipeline has a first valve and a booster pump; the outlet of the first pump is divided into two branches, one of which is connected to the heater, and the other is connected to the second container. The beneficial effect is that the second pump of the present invention is preferably a vacuum pump, one port of the second valve is connected to the air and a filter is installed, and when the pressure of the degassing device is insufficient, the second pump can be started to provide it with a certain negative pressure to ensure degassing and water supply.

[0008] More preferably, the first cleaning unit comprises a first internal cleaning pump, a first external cleaning pump, a first waste liquid pump, a first cleaning tank and a first water collector, the inlet of the first internal cleaning pump is connected to an outlet of the degassing device, and the outlet thereof has a first branch and a second branch, the first branch is provided with a first pressure regulating valve and connected to the first container, and the second branch is respectively connected to the first water collector and the sample filling unit; The inlet of the first external cleaning pump is connected to the first container, and the outlet thereof has a third branch and a fourth branch. The third branch is provided with a second pressure regulating valve connected to the first container, and the outlet of the fourth branch is divided into two paths, which are respectively connected to the water collector and the cleaning tank, and the first waste liquid pump is connected to the waste liquid container. In the present invention, the first internal cleaning pump of the sample filling module is connected to the degassing device, so that the water entering the sample needle is deoxygenated water, which effectively avoids small fluctuations caused by oxygen in the water and improves the stability of the system.

[0009] Preferably, the alkali liquid cleaning unit comprises an alkali liquid container and a cleaning pipeline connected to the alkali liquid container, and a waste discharge pipeline connected to an external drainage pipeline, the alkali liquid container is connected to the first cleaning tank through the cleaning pipeline, and an alkali liquid cleaning pump is arranged on the cleaning pipeline; the waste discharge pipeline is connected to the first cleaning tank, and a second waste liquid pump is arranged on the waste discharge pipeline. The beneficial effect is: the alkali liquid cleaning unit of the present invention soaks the inner wall and outer wall of the sample needle, discharges the waste liquid after soaking, and then uses pure water to clean the inner wall and outer wall of the sample needle to ensure the cleaning effect; the first waste liquid pump and the second waste liquid pump connected to the first cleaning tank are independent of each other. When one of the waste liquid pumps and its pipeline fails, the other waste liquid pump can be used to pump liquid, thereby reducing the risk of liquid overflow in the instrument and thus reducing instrument failure.

[0010] More preferably, there are at least two groups of sample filling units, each including a sample pump and a sample needle connected by a pipeline, and at least two groups of sample filling units are connected in parallel at the outlet of the first internal cleaning pump; there are at least two first cleaning pools, and the fourth branch of the second external cleaning pump corresponds to at least two, thereby improving the detection efficiency.

[0011] In a preferred embodiment of the present invention, the reagent filling module includes a second cleaning unit, at least one group of reagent filling units and a second cleaning tank corresponding to the reagent filling units one by one, the second cleaning unit includes a second internal cleaning pump, the outlet of the second internal cleaning pump is divided into two paths, one path is provided with a third pressure regulating valve and connected to the first container, and the other path is provided with at least one group of first cleaning reflux pipelines, the first cleaning reflux pipeline includes a first cleaning branch connected to the reagent filling unit and a first reflux branch connected to the first water collector; when not cleaning, the second internal cleaning pump is connected to the first water collector through the first reflux branch to achieve reflux and balance the pipeline pressure; when cleaning, the second cleaning pump is connected to the reagent filling unit through the first cleaning branch to clean the reagent filling unit; The second cleaning unit also includes a second external cleaning pump, the inlet of which is connected to the first container, and the outlet thereof is divided into two paths, one of which is provided with a fourth pressure regulating valve and connected to the first container, and the other is provided with at least one group of second cleaning return pipes, the second cleaning return pipes including a second cleaning branch connected to the second cleaning tank and a second return branch connected to the first water collector; the second cleaning unit also includes a third waste liquid pump and a fourth waste liquid pump connected to the second cleaning tank, the outlet of the third waste liquid pump is connected to the waste liquid container, and the outlet of the fourth waste liquid pump is connected to the external drainage pipe.

[0012] Preferably, the magnetic washing module comprises at least one set of pumping units and first suction units matched with the pumping units one by one and a third cleaning unit for cleaning the first suction units, wherein the first suction unit comprises at least one set of first suction valves, first suction pumps and first suction needles connected in sequence through pipelines; The third cleaning unit includes a third cleaning tank, a third internal cleaning pump and a third external cleaning pump. The inlet of the third internal cleaning pump and the inlet of the third external cleaning pump are both connected to the second container, the outlet of the third internal cleaning pump is connected to the inlet of the first suction valve, and the outlet of the third external cleaning pump is connected to the third cleaning tank; the third cleaning tank is connected to the waste liquid container through the fifth waste liquid pump. During actual installation, in order to increase the detection throughput, each extraction unit is equipped with two sets of first suction units, which are used as the first suction to extract the high-concentration mixed liquid and spit it into the third cleaning tank to avoid cross contamination as much as possible.

[0013] Preferably, the extraction unit includes multiple groups of extraction needle groups, solid-liquid separation needles and injection units connected to the extraction needle groups, which are arranged on the needle seat, and a liquid suction unit, each group of the extraction needle groups includes a first injection needle, an overflow prevention needle, a second injection needle, a first suction needle and a second suction needle arranged in sequence; the injection unit includes a washing liquid container, a fourth internal cleaning pump and an injection pump, a second valve and a third valve are respectively arranged on both sides of the injection pump, a first liquid distributor and a second liquid distributor are connected in parallel at the outlet of the injection pump, the first liquid distributor is connected one-to-one with the first liquid injection needle through a first liquid injection pipeline, a fourth valve is arranged on each of the first liquid injection pipelines, the second liquid distributor is connected one-to-one with the second liquid injection needle through a second liquid injection pipeline, and a fifth valve is arranged on each of the second liquid injection pipelines; the inlet of the fourth internal cleaning pump has two routes, one is connected to the second container, and the other is connected to the washing liquid container; the inlet of the fourth internal cleaning pump is connected to the second container, and the outlets of the washing liquid container and the fourth internal cleaning pump are connected in parallel at the inlet of the third valve.

[0014] The beneficial effect is that the extraction needle group of the present invention has five needles, which can realize one-time extraction and cleaning of magnetic beads in the reaction cup; if the first extraction needle or the second extraction needle is blocked during this process, there will be more residual liquid in the reaction cup after suction. At this time, when the second extraction and cleaning is performed, the first needle is used for injection, which will cause the liquid level in the reaction cup to rise. At this time, the anti-overflow needle can be used to absorb part of the liquid, thereby preventing the liquid from overflowing outside the reaction cup after the second filling, thereby reducing the risk of overflow of the reaction cup.

[0015] Preferably, the first liquid dispenser is connected to the waste liquid container via a first exhaust pipe, and the second liquid dispenser is connected to the waste liquid container via a second exhaust pipe. A first exhaust valve is provided on the first exhaust pipe, and a second exhaust valve is provided on the second exhaust pipe, so that the air can be exhausted first during internal cleaning or maintenance.

[0016] Preferably, the liquid suction unit comprises a first suction pump, a second suction pump and an anti-overflow pump, each outlet end of which is connected to the waste liquid container, the first suction needle is connected to the suction channel of the first suction pump through a first suction pipeline, and each of the second suction needles is connected to the suction channel of the second suction pump through a second suction pipeline; Multiple anti-overflow needles are connected to the anti-overflow pump through anti-overflow pipelines, or at least one anti-overflow needle is connected to the first suction pump and the remaining anti-overflow needles are connected to the anti-overflow pump, or at least one anti-overflow needle is connected to the second suction pump and the remaining second suction needles are connected to the anti-overflow pump, or at least one anti-overflow needle is connected to the first suction pump, at least one anti-overflow needle is connected to the second suction pump, and the remaining anti-overflow needles are connected to the anti-overflow pump.

[0017] The beneficial effect is that the first suction pump and the second suction pump of each injection unit of the present invention both adopt multi-channel pumps, which reduces the number of pumps and simplifies the pipeline; in addition, the first suction needle and the second suction needle are connected to different suction pumps, which minimizes the risk of clogging of the suction pump.

[0018] Compared with the prior art, the advantages of the present invention are as follows: the sample filling module of the present invention has a newly added degassing unit, which is used to remove oxygen precipitated from the water, and the purified water enters the system after being degassed by the degassing unit; the present invention has added alkaline solution cleaning on the basis of traditional water washing, and the sample needle can be soaked inside and outside and cleaned by reciprocating suction using alkaline solution, which combines water cleaning and alkaline solution cleaning to greatly ensure the cleaning effect of the sample needle. During actual installation, the sample filling unit is at least two or more groups, which effectively improves the detection efficiency. The system of the present invention is equipped with a liquid preparation module, which can realize the automatic preparation of alkaline solution and magnetic bead washing solution, and provide sufficient alkaline solution and magnetic bead washing solution for the alkaline solution cleaning unit and the magnetic washing module, respectively, to ensure the normal operation of the system. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the present invention.

[0020] Figure 2 It is a piping diagram of the sample filling module of the present invention.

[0021] Figure 3 It is a piping diagram of the reagent filling module of the present invention.

[0022] Figure 4 yes Figure 3 Piping diagram of one set of reagent filling units and one set of second cleaning units.

[0023] Figure 5 It is a piping diagram of the proportioning module described in the present invention.

[0024] Figure 6 It is a schematic diagram of the magnetic washing module of the present invention.

[0025] Figure 7 yes Figure 6 Schematic diagram of the first suction unit.

[0026] Figure 8 yes Figure 6 Schematic diagram of the middle injection needle set.

[0027] Fig. 9 yes Figure 6 Schematic diagram of the injection unit.

[0028] Fig.10 yes Figure 6 Schematic diagram of the aspiration unit.

[0029] Fig.11 It is a schematic diagram of the reagent disk cooling circulation unit and the waste sample processing unit of the present invention.

[0030] Fig.12 is a schematic diagram of a substrate unit of the present invention. DETAILED DESCRIPTION

[0031] The following is a detailed description of an embodiment of the present invention in conjunction with the accompanying drawings. This embodiment is implemented on the premise of the technical solution of the present invention, and a detailed implementation method and a specific operation process are given, but the protection scope of the present invention is not limited to the following embodiment.

[0032] It should be noted that, in the description of the present invention, relational terms such as “first” and “second” are merely used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations.

[0033] In the description of the present invention, unless otherwise clearly specified and limited, the terms "connected" and "connection" that may appear should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be the internal communication of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0034] like Figure 1As shown, the liquid circuit system for the chemiluminescent immunoassay analyzer of the present invention comprises a purified water supply module, a waste liquid container 100 for holding waste liquid, a proportioning module, a magnetic washing module for washing the magnetic beads in the reaction cup, a sample filling module, a reagent filling module and a substrate unit. The liquid circuit system also comprises a reagent disk circulation cooling unit and a waste sample treatment unit. The purified water supply module provides purified water for the proportioning module, the magnetic washing module, the sample filling module, the reagent filling module and the substrate unit. The magnetic washing module, the sample filling module, the reagent filling module, the substrate module, the reagent disk cooling circulation unit and the waste sample treatment unit are all connected to the waste liquid container to ensure normal waste discharge; wherein, the sample filling module is used to quantitatively add a sample to each reaction cup, the reagent filling module is used to quantitatively add a reagent into the reaction cup, the magnetic washing module is used to extract the mixed liquid after the reaction and wash the magnetic beads after the incubation reaction, the substrate unit injects the substrate into the reaction cup, washes the substrate off and measures light, so as to realize the automatic flow detection of the sample; The sample filling module includes a degassing unit for degassing purified water, a sample filling unit, a first cleaning unit for cleaning the sample filling unit, and an alkali solution cleaning unit; the proportioning module includes an alkali solution proportioning unit for providing alkali solution to the alkali solution cleaning unit and a washing solution proportioning unit for providing magnetic washing solution to the magnetic washing module, respectively providing sufficient alkali solution and magnetic bead washing solution to the alkali solution cleaning unit and the magnetic washing module to ensure the normal operation of the system.

[0035] The present invention separates sample filling and reagent filling, which can realize separate suction filling of samples and reagents, avoid cross contamination between samples and reagents, and greatly improve the filling efficiency of samples and reagents, improve detection efficiency, and further improve the detection throughput of the analyzer; the sample filling module of the present invention is newly added with a degassing unit, and the degassing unit is used to remove oxygen precipitated in water, and the purified water is degassed by the degassing unit before entering the system; the present invention adds alkaline solution cleaning on the basis of traditional water washing, and the alkaline solution can be used to soak the sample needle 313 inside and outside and reciprocately suction and clean it, and the water cleaning and alkaline solution cleaning are combined to greatly ensure the cleaning effect of the sample needle 313.

[0036] Combination Figure 2It can be seen that the purified water supply module has a water supply pipeline, a first container 201 and a second container 202 connected to the water supply pipeline, the water supply pipeline is connected to an external water production device, and the water supply pipeline is sequentially provided with a manual valve 203, a filtering device 204, a regulating valve 205, an electric control valve 206 and a water supply pump 207, the outlet of the water supply pump 207 is connected to the first container 201 (preferably a large-volume bucket), a weight sensor is arranged below the first container 201 or a liquid level sensor is arranged in the first container 201, and the weight sensor or the liquid level sensor is connected to the control system of the analyzer, when the liquid level of the first container 201 is lower than the minimum limit or the weight of the first container 201 is lower than the preset value, the water supply pump is powered on, the electric control valve is powered on, and water is automatically replenished into the first container 201; Similarly, a liquid level sensor is provided in the second container 202 (of course, a weight sensor may also be installed below it) to achieve automatic water replenishment to meet the needs of modules such as the magnetic washing module and the reagent filling module.

[0037] Combination Figure 2 It can be seen that the degassing unit includes a pure water pump 301, a heater 302 and a degassing device 303 (such as a degassing membrane, a gas-liquid separator) which are connected in sequence through pipelines, and the heater 302 and the degassing device 303 can be used to degas the purified water in sequence; the degassing unit also includes a pressure regulating pipeline connected to the degassing device 303, the pressure regulating pipeline is connected to the second container 202, and the second container 202 is connected to the first container 201 through a reflux pipeline, and the pressure regulating pipeline is provided with a first valve 304 and a booster pump 305; the outlet of the pure water pump 301 is divided into two branches, one of which is connected to the heater 302 to provide power for cleaning the sample filling unit; the other branch is connected to the second container 202 to provide purified water to the second container 202, and the second container 202 and the first container 201 reflux to prevent the second container 202 from overflowing due to excessive liquid level.

[0038] During actual installation, a pressure detection component (preferably a pressure detection plate) is installed at one port of the degassing device 303, the booster pump 305 is preferably a vacuum pump, and the first valve 304 is a two-position three-way solenoid valve, one port of which is connected to the atmosphere and is provided with a filter 306, which can filter the air. Before starting the booster pump 305, the first valve 304 is switched to a state connected to the air to ensure the normal start of the booster pump 305. After the booster pump 305 is started, the first valve 304 is switched to a state connected to the degassing device 303, and negative pressure is pumped on the degassing device 303 until its internal pressure is within the set range, providing sufficient power for the degassing of purified water and achieving efficient degassing.

[0039] During actual installation, the sample filling unit is divided into two groups (of course, it can also be one group or more than two groups) to improve the detection efficiency. Each group of sample filling units includes a sample needle 313 and a sample pump 314 (generally a reciprocating pump is selected, such as a plunger pump, a syringe pump or a reciprocating pump, etc.). A pressure detection module (such as a pressure sensor) is arranged between the sample needle 313 and the sample pump 314 to monitor whether the sample filling unit is blocked to ensure the normal operation of the system. Combination Figure 2 It can be seen that the first cleaning unit includes a first internal cleaning pump 307, a first external cleaning pump 308, a first waste liquid pump 309, a first cleaning pool 310 and a first water collector 311. The number of the first cleaning pools 310 is consistent with that of the sample needles 313, and the two correspond one to one, ensuring that each sample needle 313 is cleaned separately to avoid cross contamination; wherein, the inlet of the first internal cleaning pump 307 is connected to an outlet of the degassing device 303, and the outlet of the first internal cleaning pump 307 has a first branch and a second branch, and the first branch is provided with a first pressure regulating valve 311. 12 and connected to the first container 201. This branch has the function of diverting and regulating pressure. When the cleaning pressure is too high, the first pressure regulating valve 312 can be appropriately adjusted to increase the diversion of this branch. If the cleaning pressure is low, the first pressure regulating valve 312 can be appropriately adjusted to ensure the internal cleaning pressure of the sample filling unit. The second branch is respectively connected to the first water collector 311 and the sample filling unit. When not cleaning, the second branch is in a state of communication with the first water collector 311, so that the purified water in the first water collector 311 flows back to the first container 201 to balance the pipeline pressure. In actual installation, the second branch is connected to the first water collector 311 and the sample pump 314 through the sixth valve 315 (two-position three-way solenoid valve). When cleaning, the sixth valve 315 is switched to the state of communication between the sample pump 314 and the first internal cleaning pump 307. When not cleaning, the sixth valve 315 is switched to the state of communication between the first water collector 311 and the first container 201 to achieve reflux. The inlet of the first external cleaning pump 308 is connected to the first container 201, and its outlet has a third branch and a fourth branch. The third branch is provided with a second pressure regulating valve 317 connected to the first container 201, and the outlet of the fourth branch has two secondary branches, one of which is connected to the first water collector 311, and the other is connected to the first cleaning tank 310. The third branch is a pressure regulating branch, and the cleaning pressure can be adjusted by adjusting the opening of the second pressure regulating valve 317; the fourth branch and its two secondary branches are connected through the seventh valve 318 (i.e., a two-position three-way battery valve connection) (of course, an electromagnetic valve can also be installed in each secondary branch). During cleaning, the seventh valve 318 is switched to a state of connection with the first cleaning tank 310, and purified water is injected into the first cleaning tank 310 to achieve external cleaning; when not cleaning, the seventh valve 318 is switched to a state of connection with the first water collector 311, and purified water is injected into the first water collector 311, and refluxed to the first container 201 through the first water collector 311; the first waste liquid pump 309 is connected to the waste liquid container 100, and the waste liquid generated during the cleaning process is pumped into the waste liquid container 100.

[0040] The present invention utilizes the first internal cleaning pump 307, the first external cleaning pump 308, the sixth valve 315, and the seventh valve 318 to realize the separate control of two groups of sample filling units. The two groups of sample filling units can be cleaned at the same time, or only one of them can be cleaned, thereby improving the filling efficiency of the sample in the reaction cup and further improving the detection efficiency of the instrument. In addition, during the actual installation, a pressure detection module (such as a pressure sensor) is provided on the second branch of the first internal cleaning pump 307 and the fourth branch of the first external cleaning pump 308 to monitor the flow state of each branch, but the control system of the analyzer can issue a blockage alarm when blocked.

[0041] Combination Figure 2 It can be seen that the alkali liquid cleaning unit includes an alkali liquid container 319 and a cleaning pipeline connected to the alkali liquid container 319, and a waste discharge pipeline connected to the external liquid discharge pipeline. The alkali liquid container 319 is connected to the first cleaning tank 310 through the cleaning pipeline, and an alkali liquid cleaning pump 320 is provided on the cleaning pipeline; the waste discharge pipeline is connected to the first cleaning tank 310, and a second waste liquid pump 321 and a waste discharge valve 322 are provided on the waste discharge pipeline; Each first cleaning tank 310 has a cleaning pipeline and a waste discharge pipeline, which can realize the separate injection of liquid (alkaline solution) into each first cleaning tank 310, and further realize the separate control of each sample filling unit, so as to avoid cross contamination between samples as much as possible and improve the reliability of the detection results.

[0042] When the sample needle 313 needs to be cleaned with alkaline solution, the alkaline solution cleaning pump 320 is powered on, a certain volume of alkaline solution is injected into the cleaning tank, and the sample needle 313 is immersed in the first cleaning tank 310 to soak and clean its inner and outer walls. After soaking, the second waste liquid pump 321 can be used to extract the waste liquid after soaking; of course, during the alkaline solution cleaning process, the sample pump 314 can be used for reciprocating suction, thereby achieving alkaline solution cleaning of the sample pump 314 and the sample needle 313 to ensure the cleaning effect.

[0043] In the present invention, each first cleaning tank 310 is connected to two waste liquid pumps, one waste liquid pump is connected to the waste liquid container 100, and the other waste liquid pump is connected to the external drainage pipeline. When one of the waste liquid pumps fails, the other waste liquid pump can work and waste can still be discharged, thereby avoiding waste liquid from overflowing from the first cleaning tank 310 as much as possible.

[0044] During the actual cleaning, in order to ensure the cleaning effect of each sample needle, the sample needle can be first cleaned with water inside and outside by the first internal cleaning pump 307 and the first external cleaning pump 308, and then cleaned with alkali solution by the alkali solution cleaning unit, and finally cleaned with water inside and outside by the first internal cleaning pump 307 and the second internal cleaning pump 308. To prevent the alkali solution from flowing back, a one-way valve is installed at the outlet of each alkali solution cleaning pump 320, and a filter is installed at the inlet of the alkali solution cleaning pump to prevent impurities in the alkali solution from entering the system; one-way valves are installed at the outlets of the first waste liquid pump 309 and the second waste liquid pump 321 to prevent the waste liquid from flowing back into the first cleaning tank 310.

[0045] Combination Figure 3-4 It can be seen that the reagent filling module includes a second cleaning unit, four groups of reagent filling units and a second cleaning pool 403 corresponding to the reagent filling units one by one, the reagent filling unit includes a reagent needle 401 and a reagent pump 402 (a pressure detection module is provided between the two to monitor the pressure); the second cleaning unit includes a second internal cleaning pump 404, and the outlet of the second internal cleaning pump 404 is divided into two paths, one of which is provided with a third pressure regulating valve 405 and connected to the first container 201 (the path has a shunting effect and is used to adjust the pressure of the other path), and the other path is provided with four groups of first cleaning reflux pipelines, and the first cleaning reflux pipeline includes a first cleaning branch 406 connected to the reagent filling unit and a first reflux branch 407 connected to the first water collector 311; A third liquid distributor 408 is installed on a branch of the second internal cleaning pump 404, and four groups of first cleaning return pipelines are respectively connected to the third liquid distributor 408. Each group of first cleaning branch 406 and first return branch 407 is connected to the third liquid distributor 408 through the eighth valve 409 (i.e., a two-position three-way solenoid valve) (of course, solenoid valves can also be installed on the two branches respectively). During cleaning, the eighth valve 409 is switched to a state of being connected to the reagent filling unit, and the reagent filling unit is internally cleaned, and the pressure is adjusted by the third pressure regulating valve 405; when not cleaning, the eighth valve 409 is switched to a state of being connected to the third liquid distributor 408 and the first water collector 311, so that the purified water flows back to the first container 201 through the third liquid distributor 408 and the first water collector 311.

[0046] Combination Figure 3-4 It can be seen that the second cleaning unit also includes a second external cleaning pump 410, the inlet of the second external cleaning pump 410 is connected to the first container 201, and the outlet thereof is divided into two paths, one of which is provided with a fourth pressure regulating valve 411 and connected to the first container 201, and the other is provided with a second cleaning reflux pipeline, the second cleaning reflux pipeline includes a second cleaning branch 414 connected to the second cleaning tank 403 and a second reflux branch 413 connected to the first water collector 311; similarly, a fourth liquid distributor 415 can be installed at an outlet of the second external cleaning pump 410, and four groups of second cleaning reflux pipelines are all connected to the fourth liquid distributor 415, and each group of second cleaning branch 414 and second reflux branch 413 is connected to the fourth liquid distributor 415 through a ninth valve 412 (a two-position three-way solenoid valve) (of course, a solenoid valve can also be installed on each branch), and during cleaning, the second external cleaning pump 410 and the second cleaning tank 403 are in a connected state, and purified water can be injected into the second cleaning tank 403; The four groups of reagent filling units of the present invention share a second external cleaning pump 410. When any group of reagent filling units needs to be cleaned, the second external cleaning pump 410 is in a powered-on state. For the reagent filling units that do not need to be cleaned, the corresponding ninth valve 412 is switched to a state of being connected to the first water collector 311, so that the purified water flows back into the first water collector 311, and then flows back into the first container 201 through the first water collector 311; for the reagent filling units that need to be cleaned, the corresponding second cleaning tank is switched to be connected to the fourth liquid dispenser. The present invention can realize the separate control of the four groups of reagent filling units and meet the diversified requirements of the analyzer.

[0047] Combination Figure 3-4It can be seen that the second cleaning unit also includes a third waste liquid pump 416 and a fourth waste liquid pump 417 connected to the second cleaning tank 403. An electromagnetic valve is arranged between the third waste liquid pump 416 and the second cleaning tank 403. The fourth waste liquid pump 417 is connected to the side outlet of the second cleaning tank 403. When one of the waste liquid pumps fails, the other waste liquid pump can work to discharge waste and prevent waste liquid from overflowing from the second cleaning tank 403.

[0048] During actual installation, pressure sensors are provided in both the fourth liquid distributor 415 and the third liquid distributor 408 to monitor the pressure in the liquid distributors. When the water pressure is too high, the water can be diverted through the corresponding pressure regulating valves.

[0049] Combination Figure 5 It can be seen that the alkali solution proportioning unit includes a concentrated alkali solution container 501 and an alkali solution pump 502, and the washing solution proportioning unit includes a concentrated washing solution container 503 and a washing solution pump 504. The alkali solution proportioning unit and the washing solution proportioning unit share a water pump 505, the inlet of the water pump 505 is connected to the second container 202, and its outlet is divided into two paths through the tenth valve 506 (a two-position three-way solenoid valve), one path is connected to the alkali solution container 319, and the other path is connected to the washing solution container 601 of the magnetic washing module. The concentrated alkali solution container 501 is connected to the alkali solution container 319 through the alkali solution pump 502, and the concentrated washing solution container 503 is easily connected to the washing solution through the washing solution pump 504; weight sensors are provided below the alkali solution container 319 and the washing solution container 601, and the amount of water and the amount of concentrated solution added to each container are controlled according to the weight, thereby realizing automatic proportioning of the alkali solution and the magnetic bead washing solution. In the actual installation, a weight sensor can be installed below the concentrated alkali solution container 501 and the concentrated washing liquid container 503 to determine the amount of concentrated liquid added to the alkali solution container or the washing liquid container according to the weight change, so as to further improve the liquid preparation accuracy.

[0050] Combination Figure 6-10 It can be seen that the magnetic washing module includes two groups of pumping units, a first suction unit matched with each group of pumping units, and a third cleaning unit for cleaning each group of first suction units. The first suction unit has two groups of first suction valves 602, first suction pumps 603 and first suction needles 604 connected in sequence through pipelines. The two groups of needles are used together to improve the detection efficiency. The third cleaning unit includes a third cleaning tank 605, a third internal cleaning pump 606 and a third external cleaning pump 607. The inlet of the third internal cleaning pump 606 and the inlet of the third external cleaning pump 607 are both connected to the second container 202, the outlet of the third internal cleaning pump 606 is respectively connected to the inlets of the two first suction valves 602 (that is, the two first suction needles 604 are connected in parallel at the outlet of the third internal cleaning pump 606), and the outlet of the third external cleaning pump 607 is connected to the third cleaning tank 605; the third cleaning tank 605 is connected to the waste liquid container 100 through the fifth waste liquid pump 608.

[0051] During the first suction, the first suction needle 604 is moved to the top of the reaction cup, the first suction pump 603 is powered on, the mixed liquid in the reaction cup is extracted, and the first suction needle 604 is moved to the top of the third cleaning tank 605, and the first suction pump 603 spits the extracted mixed liquid into the third cleaning tank 605; the third internal cleaning pump 606, the third external cleaning pump 607, the fifth waste liquid pump 608 and the first suction valve 602 are powered on, and the first suction needle 604 is internally and externally cleaned. The waste liquid generated by the cleaning enters the waste liquid container 100 through the fifth waste liquid pump 608. During the internal cleaning process, in order to ensure the cleaning effect of the first suction pump 603, the third internal cleaning pump 606 can be turned off, and the first suction pump 603 is used to suck purified water, and then the purified water is spit out. This is repeated to achieve the cleaning of the first suction pump 603 and the first suction needle 604 and ensure the cleaning effect.

[0052] The extraction unit includes five groups of extraction needles arranged on the needle seat (it can also be three groups, four groups or six groups, etc.), a liquid injection unit connected to the solid-liquid separation needle 630 and the extraction needle group, and a liquid suction unit. Each group of extraction needles includes a first liquid injection needle 609, an anti-overflow needle 610, a second liquid injection needle 611, a first suction needle 612 and a second suction needle 613 arranged in sequence. Since the magnetic bead washing solution is mostly a crystalline washing solution, the suction needle in the extraction needle group has a risk of clogging. Once blocked, the excess liquid in the reaction cup cannot be extracted. When the next round of extraction and cleaning is performed, if the excess liquid is not extracted, the liquid in the reaction cup will overflow after two fillings. The present invention adds an anti-overflow needle 610 between two injection needles, the bottom heights of the first injection needle 609 and the second injection needle 611 are consistent, the bottom height of the first suction needle 612 is higher than the bottom height of the second suction needle 613, the bottom height of the anti-overflow needle 610 is lower than the first injection needle 609 and higher than the first suction needle 612. When the suction needle of the upper group of injection needles is not blocked, the cleaned liquid can be extracted. When the first injection needle is sampled during the next group of extraction and sampling, the bottom height of the anti-overflow needle is higher than the first suction needle after sampling, and no liquid is extracted from the anti-overflow needle. When the suction needle of the upper group of injection needles is blocked, when the lower group of injection needles passes through the anti-overflow needle after the first filling, the anti-overflow needle can extract the excess liquid caused by the blockage to avoid liquid overflow in the reaction cup after the second filling.

[0053] Combination Figure 6-10It can be seen that the injection unit includes a fourth internal cleaning pump 614 and an injection pump 615, and the second valve 616 and the third valve 617 are respectively arranged on both sides of the injection pump 615. The inlet of the fourth internal cleaning pump 614 (preferably a diaphragm pump, when it is closed, the pipeline where it is located is in a passage under the action of external force) is connected to the second container 202, and its outlet is connected to the injection pump 615 through the third valve 617; the washing liquid container 601 is connected to the plunger pump, and the washing liquid container 601, the third valve 617 and the outlet of the fourth internal cleaning pump 614 are connected together through the eleventh valve 618 (a two-position three-way solenoid valve). When the washing liquid is cleaned, the eleventh valve 618 is switched to a state where the injection pump 615 and the washing liquid container 601 are connected, and when the internal cleaning is performed, the eleventh valve 618 is switched to a state where the injection pump 615 and the fourth internal cleaning pump 614 are connected; the injection pump 61 5 is connected in parallel with a first liquid dispenser 619 and a second liquid dispenser 620, the first liquid dispenser 619 is connected one-to-one with the first liquid injection needle 609 through the first liquid injection pipeline, and a fourth valve 621 is provided on each first liquid injection pipeline, and the second liquid dispenser 620 is connected one-to-one with the second liquid injection needle 611 through the second liquid injection pipeline, and a fifth valve 622 is provided on each second liquid injection pipeline; the liquid injection pump 615 can be connected not only to purified water, but also to the washing liquid container 601, so as to realize quantitative filling of magnetic bead washing liquid and internal cleaning of each liquid injection needle; the first liquid dispenser 619 is connected to the waste liquid container 100 through the first exhaust pipeline, and the second liquid dispenser 620 is connected to the waste liquid container 100 through the second exhaust pipeline, a first exhaust valve 622 is provided on the first exhaust pipeline, and a second exhaust valve 623 is provided on the second exhaust pipeline. During the internal flushing process, the fourth internal cleaning pump 614 is turned on to fill the entire pipeline with purified water, thereby discharging the bubbles in the first liquid distributor 619 and the second liquid distributor 620. In addition, the injection pump 615 injects liquid to each injection needle through the liquid distributor, which can balance the pipeline pressure and thus ensure high-precision injection of each branch; since the pipeline flow resistance of each branch is different, the intervals of the multiple fourth valves 621 and the intervals of the multiple fifth valves 622 can be opened according to the pipeline flow resistance in actual operation, ensuring the consistency of the multiple first injection needles 609 and the consistency of the second injection needles 611.

[0054] Combination Figure 6-10 It can be seen that the liquid suction unit includes a first suction pump 624, a second suction pump 625 and an anti-overflow pump 626, whose outlet ends are all connected to the waste liquid container 100, the first suction needle 612 is connected to the suction channel of the first suction pump 624 through the first suction pipeline, and each second suction needle 613 is connected to the suction channel of the second suction pump 625 through the second suction pipeline. The first suction pump 624, the second suction pump 625 and the anti-overflow pump 626 all have multiple flow channels, which can meet the connection requirements of multiple suction needles and anti-overflow needles 610, reduce the number of pumps, and thus simplify the pipeline; each injection unit has two matching suction pumps, which also reduces the failure rate to a certain extent; Each group of pumping units has five anti-overflow needles 610. The three channels of the anti-overflow pump 626 are connected to the three anti-overflow needles 610 of one group of pumping units through an anti-overflow pipeline. One anti-overflow needle 610 is connected to the first suction pump 624, and another anti-overflow needle 610402 is connected to the second suction pump 625. The five anti-overflow needles 610 are installed on different pumps, thereby reducing the failure rate of the anti-overflow pipeline. The installation method of the anti-overflow needle 610 of the other group of pumping units is consistent with the installation method of the anti-overflow needle 610 of the first group of pumping units, thereby reducing the failure rate of the anti-overflow needle 610. Of course, during actual installation, the number of anti-overflow needles 610 can be six or more or four, three, etc. When the number of anti-overflow needles 610 is small, the anti-overflow needles 610 can be connected to two suction pumps respectively, or two or two anti-overflow needles 610 can be connected to the anti-overflow pump 626, and two or one anti-overflow needle 610 can be connected to one of the suction pumps; when the number of anti-overflow needles 610 is large, an additional anti-overflow pump 626 can be added.

[0055] During the actual installation, each channel of the first suction pump 624 is connected to the first liquid collector 627, and the first liquid collector 627 is connected to the waste liquid container 100 through a pipeline, so that the extracted waste liquid first enters the first liquid collector 627, and then enters the waste liquid container 100 through the first liquid collector 627; similarly, the outlet of each channel of the second suction pump 625 is connected to the second liquid collector 628, and the second liquid collector 628 is connected to the waste liquid container 100 through a pipeline, so that the extracted waste liquid first enters the second liquid collector 628, and then enters the waste liquid container 100 through the second liquid collector 628. The two liquid collectors have a buffering effect to balance the pipeline pressure of the suction unit. In addition, in order to reduce the number of liquid collectors, when there are two suction units, the outlet of the second suction pump 625 of the second suction unit can be connected to its first liquid collector 627 or the liquid collector of another suction unit respectively to reduce the number of liquid collectors, as shown in the figure. During actual installation, the present invention connects the first liquid collector 627 and the third liquid collector 629 through a pipeline, and installs a liquid level sensor (of course, it can also be a weight sensor or a pressure sensor, etc.). When liquid is detected, it means that the anti-overflow needle 610 has extracted excess liquid in the reaction cup, indicating that the first suction needle 604, the first suction needle 612 and / or the second suction needle 613 are blocked.

[0056] Combination Fig.10It can be seen that the solid-liquid separation needle 630 is connected to the first liquid collector 627 through a separation pipeline, and a separation pump 631 is provided on the separation pipeline. During the detection process, a detection process after the magnetic beads are washed is to add a substrate for photometric detection. After the photometric detection, there is often a substrate solution in the reaction cup. The solid-liquid separation needle 630 and the separation pump 631 can be used to extract the waste liquid in the reaction cup into the first liquid collector 627, and then discharge it into the waste liquid container 100 through the first liquid collector 627, and then the waste liquid after photometric detection is extracted to achieve solid-liquid separation.

[0057] The present invention has two injection units, and the injection pumps 615 of the two injection units are connected in parallel, so that the two injection pumps 615 can be controlled separately. Since the magnetic bead washing solution is a solution that is easy to crystallize, it is usually necessary to flush and maintain the pipeline and the injection needle after adding the magnetic bead washing solution to avoid blockage caused by crystallization of the pipeline and the injection needle. The specific maintenance is as follows: switch the eleventh valve 618 to a state connected to the second container 202, power on the fourth internal cleaning pump 614, power on the second valve 616 and the third valve 617, the fourth valve 621, and the fifth valve 622 of the injection unit, and pump purified water into the first liquid separator 619 and the second liquid separator 620, respectively, and enter the waste liquid container 100 through the first exhaust pipeline and the second exhaust pipeline, and discharge the bubbles in the two liquid separators. ; The fourth internal cleaning pump 614 is powered off (after the power is off, the branch is in a state where it can flow under external force), the two injection pumps 615 are powered on at the same time, each second valve 616 and the exhaust valve are powered off, and the injection pump 615 is filled with water; the second valve 616 is powered on and the third valve 617 is powered off, the fourth valve 621 and the fifth valve 622 are powered on, and the injection pump 615 injects pure water into each first injection needle 609 and the second injection needle 611 to achieve internal cleaning; the suction pump and the anti-overflow pump 626 are used to suck out the purified water injected into the reaction disk by the injection needle to achieve internal cleaning of the suction needle and the anti-overflow needle 610, and avoid crystallization as much as possible.

[0058] The reaction disk (card-mounted reaction cup) of the analyzer is usually rotatable, and the extraction needle group 400 can be moved to the bottom of the reaction disk, thereby realizing continuous extraction and cleaning of multiple reaction cups. The specific process is as follows: after maintenance, the eleventh valve 618 is switched to a state where the injection pump 615 and the washing liquid container 601 are connected, the injection pump 615 and the third valve 617 are powered on to extract the magnetic bead washing liquid, and the plunger pump extracts the magnetic bead washing liquid in the washing liquid container 601; then the third valve 617 is powered off, and the second valve 616, the fourth valve 621, and the fifth valve 622 are all powered on, so that the magnetic bead washing liquid is injected into each injection needle after the liquid dispenser and the injection pipeline, thereby realizing simultaneous filling of multiple injection needles; If there is no reaction cup under the injection needle, the valve on the injection pipeline corresponding to the injection needle is in a power-off state; after injection, the reaction disk is rotated to a certain angle so that the reaction cup is located correspondingly under the suction needle, and the suction pump and the anti-overflow pump 626 are powered on to pump the cleaned waste liquid into the waste liquid container 100 to achieve suction; the cleaned reaction cup enters the photometric module of the analyzer, and photometry is performed after the substrate is added. After photometry, the reaction cup returns to the reaction disk again, and the waste liquid is extracted using the solid-liquid separation needle 630.

[0059] Combination Fig.11 It can be seen that the reagent disk circulating cooling unit includes a circulating loop formed by a circulating pump 701, a cooling medium container 702, a reagent disk 703 and a radiator 704 connected in sequence. The reagent disk is cooled by the circulating loop. The reagent disk 703 is connected to the waste liquid container 100 through the sixth waste liquid pump 705, which can discharge waste liquid and facilitate the replacement of the cooling medium. The cooling medium container 702 is provided with an exhaust port, and the gas in the circulating pipeline is discharged from the exhaust port.

[0060] Combination Fig.12 It can be seen that the substrate unit includes a first substrate container 801, a first substrate pump 802, a first substrate valve 803 and a first substrate needle 804 connected by a pipeline, and also includes a second substrate container 805, a second substrate pump 806, a second substrate valve 807 and a second substrate needle 808 connected by a pipeline, and also includes a fourth cleaning tank 811, a fourth external cleaning pump 809 and a seventh waste liquid pump 810, wherein the inlet of the fourth external cleaning pump 809 is connected to the second container 202, and the outlet thereof is connected to the fourth cleaning tank 811, and the inlet of the seventh waste liquid pump 810 is connected to the fourth cleaning tank 811 is connected, and its outlet is connected to the waste liquid container 100; a third substrate valve 812 is arranged between the first substrate pump 802 and the first substrate container 801, and a fourth substrate valve 813 is arranged between the second substrate pump 806 and the second substrate container 805. When filling, the third substrate valve 812 and the fourth substrate valve 813 are opened respectively, and the two substrate pumps are powered on respectively to realize the extraction of substrate liquid; after extraction, the third substrate valve 812 and the fourth substrate valve 813 are turned off, and the substrate pumps are used to inject the substrate liquid into the reaction cup respectively, and the two substrates can be injected successively.

[0061] To ensure the normal operation of the substrate unit, there are two first substrate containers 801 connected in parallel, and there are two second substrate containers 805 connected in parallel. To facilitate the connection between the substrate pump and the substrate container, the substrate container can be integrated on a dispenser with two independent chambers, and the substrate pumps can be connected to the dispensers respectively.

[0062] After the substrate is filled, the fourth external cleaning pump 809 can be used to inject purified water into the fourth cleaning tank 811, and the two substrate needles can be immersed in the fourth cleaning tank 811, and the substrate needles can be soaked in purified water; the waste liquid generated by the soaking is discharged into the waste liquid container 100 through the seventh waste liquid pump 810 to achieve external cleaning of the substrate needles.

[0063] During the detection process, waste samples are inevitably generated, and the waste sample processing unit can be used to pump the liquid in the reaction cup into the waste liquid container 100 to achieve rapid processing of the waste samples. The waste sample processing unit includes a waste sample pump 901 and a waste sample suction needle 902 connected in sequence through a pipeline, and the outlet of the waste sample pump 901 is connected to the waste liquid container 100. After the waste sample pump 901 is powered on, the liquid in the reaction cup can be pumped into the waste liquid container 100.

[0064] During actual installation, the sample pump 314 , the reagent pump 402 , the injection pump 615 , the first substrate pump 802 , and the second substrate pump 806 are preferably pumps with reciprocating performance, such as a plunger pump, a syringe pump, and a reciprocating pump.

[0065] Finally, it should be emphasized that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions recorded in the aforementioned embodiments without creative work, or replace some of the technical features therein with equivalents. Therefore, any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A liquid circuit system for a chemiluminescent immunoassay analyzer, comprising a purified water supply module, a waste liquid container for containing waste liquid, a proportioning module, a magnetic washing module for washing magnetic beads in a reaction cup, a sample filling module, a reagent filling module and a substrate unit, characterized in that: The liquid circuit system also includes a reagent tray circulation cooling unit and a waste sample processing unit; the magnetic washing module, sample filling module, reagent filling module and substrate unit are all connected to the waste liquid container, and the proportioning module, magnetic washing module, sample filling module, reagent filling module and substrate unit are all connected to the purified water supply module; the sample filling module includes a degassing unit for degassing purified water, a sample filling unit and a first cleaning unit and an alkali solution cleaning unit for cleaning the sample filling unit; the proportioning module includes an alkali solution proportioning unit for providing alkali solution to the alkali solution cleaning unit and a washing solution proportioning unit for providing magnetic washing washing solution to the magnetic washing module.

2. The liquid path system for a chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The purified water supply module comprises a water supply pipeline, a first container and a second container connected to the water supply pipeline; The degassing unit comprises a pure water pump, a heater and a degassing device which are sequentially connected through pipelines, and also comprises a pressure regulating pipeline connected to the degassing device, the pressure regulating pipeline is connected to the second container, and the second container is connected to the first container through a reflux pipeline, and the pressure regulating pipeline is provided with a first valve and a booster pump; The outlet of the first pump is divided into two branches, one of which is connected to the heater, and the other is connected to the second container.

3. The liquid path system for a chemiluminescent immunoassay analyzer according to claim 2, characterized in that: The first cleaning unit comprises a first internal cleaning pump, a first external cleaning pump, a first waste liquid pump, a first cleaning tank and a first water collector, the inlet of the first internal cleaning pump is connected to an outlet of the degassing device, and the outlet thereof has a first branch and a second branch, the first branch is provided with a first pressure regulating valve and is connected to the first container, and the second branch is respectively connected to the first water collector and the sample filling unit; The inlet of the first external cleaning pump is connected to the first container, and its outlet has a third branch and a fourth branch. The third branch is provided with a second pressure regulating valve connected to the first container, and the outlet of the fourth branch is divided into two branches, which are respectively connected to the water collector and the cleaning tank, and the first waste liquid pump is connected to the waste liquid container.

4. The liquid path system for a chemiluminescent immunoassay analyzer according to claim 2, characterized in that: The alkali liquid cleaning unit includes an alkali liquid container and a cleaning pipeline connected to the alkali liquid container, and a waste discharge pipeline connected to an external drainage pipeline. The alkali liquid container is connected to the first cleaning tank through the cleaning pipeline, and an alkali liquid cleaning pump is arranged on the cleaning pipeline; the waste discharge pipeline is connected to the first cleaning tank, and a second waste liquid pump is arranged on the waste discharge pipeline.

5. The liquid path system for a chemiluminescent immunoassay analyzer according to claim 3, characterized in that: There are at least two groups of sample filling units, each including a sample pump and a sample needle connected by a pipeline. At least two groups of sample filling units are connected in parallel at the outlet of the first internal cleaning pump; there are at least two first cleaning pools, and the fourth branch of the second external cleaning pump corresponds to at least two.

6. The liquid path system for a chemiluminescent immunoassay analyzer according to claim 3, characterized in that: The reagent filling module includes a second cleaning unit, at least one group of reagent filling units and a second cleaning tank corresponding to the reagent filling units one by one, the second cleaning unit includes a second internal cleaning pump, the outlet of the second internal cleaning pump is divided into two paths, one path is provided with a third pressure regulating valve and connected to the first container, and the other path is provided with at least one group of first cleaning return pipelines, the first cleaning return pipeline includes a first cleaning branch connected to the reagent filling unit and a first return branch connected to the first water collector; The second cleaning unit also includes a second external cleaning pump, the inlet of which is connected to the first container, and the outlet thereof is divided into two paths, one of which is provided with a fourth pressure regulating valve and connected to the first container, and the other is provided with at least one group of second cleaning return pipes, the second cleaning return pipes including a second cleaning branch connected to the second cleaning tank and a second return branch connected to the first water collector; the second cleaning unit also includes a third waste liquid pump and a fourth waste liquid pump connected to the second cleaning tank, the outlet of the third waste liquid pump is connected to the waste liquid container, and the outlet of the fourth waste liquid pump is connected to the external drainage pipe.

7. The liquid path system for a chemiluminescent immunoassay analyzer according to claim 2, characterized in that: The magnetic washing module includes at least one set of pumping units, a first suction unit matched with the pumping units one by one, and a third cleaning unit for cleaning the first suction unit, wherein the first suction unit has at least one set of a first suction valve, a first suction pump and a first suction needle connected in sequence through a pipeline; The third cleaning unit includes a third cleaning tank, a third internal cleaning pump and a third external cleaning pump. The inlet of the third internal cleaning pump and the inlet of the third external cleaning pump are both connected to the second container, the outlet of the third internal cleaning pump is connected to the inlet of the first suction valve, and the outlet of the third external cleaning pump is connected to the third cleaning tank; the third cleaning tank is connected to the waste liquid container through a fifth waste liquid pump.

8. The liquid path system for a chemiluminescent immunoassay analyzer according to claim 7, characterized in that: The injection unit includes multiple groups of injection needle groups arranged on the needle seat, a liquid injection unit connected to the solid-liquid separation needle and the injection needle group, and a liquid suction unit, each group of the injection needle group includes a first injection needle, an anti-overflow needle, a second injection needle, a first suction needle and a second suction needle arranged in sequence; The injection unit comprises a washing liquid container, a fourth internal cleaning pump and an injection pump, a second valve and a third valve are respectively arranged on both sides of the injection pump, a first liquid dispenser and a second liquid dispenser are connected in parallel at the outlet of the injection pump, the first liquid dispenser is connected one-to-one with the first liquid injection needle through the first liquid injection pipeline, a fourth valve is arranged on each of the first liquid injection pipelines, the second liquid dispenser is connected one-to-one with the second liquid injection needle through the second liquid injection pipeline, and a fifth valve is arranged on each of the second liquid injection pipelines; The inlet of the fourth internal cleaning pump is connected to the second container, and the outlets of the washing liquid container and the fourth internal cleaning pump are connected in parallel at the inlet of the third valve.

9. The liquid path system for a chemiluminescent immunoassay analyzer according to claim 8, characterized in that: The first liquid dispenser is connected to the waste liquid container via a first exhaust pipeline, the second liquid dispenser is connected to the waste liquid container via a second exhaust pipeline, a first exhaust valve is provided on the first exhaust pipeline, and a second exhaust valve is provided on the second exhaust pipeline.

10. The liquid path system for a chemiluminescent immunoassay analyzer according to claim 8, characterized in that: The liquid suction unit comprises a first suction pump, a second suction pump and an anti-overflow pump, each outlet end of which is connected to the waste liquid container, the first suction needle is connected to the suction channel of the first suction pump through a first suction pipeline, and each of the second suction needles is connected to the suction channel of the second suction pump through a second suction pipeline; Multiple anti-overflow needles are connected to the anti-overflow pump through anti-overflow pipelines, or at least one anti-overflow needle is connected to the first suction pump and the remaining anti-overflow needles are connected to the anti-overflow pump, or at least one anti-overflow needle is connected to the second suction pump and the remaining second suction needles are connected to the anti-overflow pump, or at least one anti-overflow needle is connected to the first suction pump, at least one anti-overflow needle is connected to the second suction pump, and the remaining anti-overflow needles are connected to the anti-overflow pump.

Images