A method and device for detecting sealing process defects of freeze-dried medicine bottles

Abstract

The present invention discloses a method and device for detecting sealing process defects for freeze-dried medicine bottles, which are applied to the technical field of sealing detection of freeze-dried medicine bottles, and include a shell, a transmission mechanism, a rotating mechanism, and a detection mechanism. The transmission mechanism is arranged on the left side of the shell and is used to transport the freeze-dried medicine bottles. The rotating mechanism is arranged in the middle of the shell and is used to move the freeze-dried medicine bottles on the transmission mechanism to the bottom of the detection mechanism. The detection mechanism is located in front of the shell, and the sealing of the freeze-dried medicine bottles is detected when the freeze-dried medicine bottles move to the bottom of the detection mechanism. The rotating mechanism includes a rotating component and an extrusion component, wherein: the extrusion component includes an electric telescopic rod 1 and a mounting rod fixed on the shell, two groups of the electric telescopic rods 1 are slidably connected with lifting rods, and the output ends of the two groups of the electric telescopic rods 1 are fixedly connected to the lifting rods. The present invention can accurately detect the conditions of the freeze-dried medicine bottles.

Description

Technical Field

[0001] The present invention relates to the technical field of freeze-dried medicine bottle sealing detection, and in particular to a method and equipment for detecting sealing process defects of freeze-dried medicine bottles. Background Art

[0002] In the field of pharmaceutical production, freeze-dried drug bottles are a common form of drug packaging, and their sealing performance is crucial. Good sealing is a key factor in ensuring stable drug quality, effective preservation, and preventing microbial contamination. Once there is a problem with the sealing of the freeze-dried drug bottle, the drug may be affected by external environmental factors, such as the invasion of moisture, oxygen, and microorganisms, which may cause the drug to deteriorate, reduce its efficacy, and even cause safety hazards, seriously threatening the life and health of patients. Therefore, it is necessary to test the sealing of the freeze-dried drug bottle.

[0003] At present, a variety of detection methods have been developed for the seal detection of freeze-dried drug bottles. Among the physical detection methods, the vacuum decay method and the pressure decay method are widely used. However, freeze-dried drugs need to be stored at low temperatures, and the existing physical detection methods do not have detection methods for different temperature conditions, so it is impossible to accurately detect the condition of freeze-dried drug bottles. This phenomenon has become a problem that people in this field need to solve urgently. Summary of the invention

[0004] The object of the present invention is to provide a method and device for detecting sealing process defects of freeze-dried medicine bottles to solve the problems raised in the above-mentioned background technology.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions: a sealing process defect detection device for freeze-dried medicine bottles, comprising a shell, a transmission mechanism, a rotating mechanism, and a detection mechanism, wherein the transmission mechanism is arranged on the left side of the shell and is used to transport the freeze-dried medicine bottles, the rotating mechanism is arranged in the middle of the shell and is used to move the freeze-dried medicine bottles on the transmission mechanism to the bottom of the detection mechanism, the detection mechanism is located in front of the shell, and the sealing of the freeze-dried medicine bottles is detected when the freeze-dried medicine bottles are moved to the bottom of the detection mechanism;

[0006] The rotating mechanism comprises a rotating assembly and an extruding assembly, wherein:

[0007] The extrusion assembly includes an electric telescopic rod 1 and a mounting rod fixed on the shell, and the electric telescopic rod 1 and the mounting rod are each provided with two groups, and the two groups of the electric telescopic rod 1 are provided on one side of the rotating assembly, and the two groups of the electric telescopic rod 1 are slidably connected with a lifting rod, and the output ends of the two groups of the electric telescopic rod 1 are fixedly connected to the lifting rod;

[0008] The lifting rod is connected to a plurality of connection blocks through telescopic driving, a brush plate is fixed on the connection block, and a plurality of brush heads are arranged on the brush plate;

[0009] The detection mechanism includes a lifting component, an inflation component and a cleaning component, wherein:

[0010] The inflation component includes an inflation tank fixed on the shell, a second fixing seat and a support column fixed on the shell, a low-temperature gas cavity and a high-temperature gas cavity are arranged inside the inflation tank, an inflation tube 1 is connected to the low-temperature gas cavity, a hollow cylinder is fixed on the second fixing seat, the top of the hollow cylinder is connected to the inflation tube 1, a pressure gauge 1 and a first air pump are connected to the inflation tube 1, a sealing cover shell 1 is fixed to the output end of the hollow cylinder, and the sealing cover shell 1 is located above the freeze-dried medicine bottle;

[0011] A connecting frame is fixed on the top of the support column, and an electric telescopic rod 2 is fixed on the connecting frame. A sealing cover 2 is fixed on the output end of the electric telescopic rod 2. A second inflatable tube is connected to one side of the sealing cover 2. The other end of the second inflatable tube is connected to the high-temperature gas chamber. A second barometer and a second air pump are connected to the second inflatable tube in sequence.

[0012] The bottom of the sealed cover shell 1 is penetrated by a central tube, a plurality of through holes are provided on the outside of the central tube, a plurality of lighting lamps are fixed on the outside of the central tube, a sealing groove 1 is provided at the bottom of the sealed cover shell 1, a sealing groove 2 is provided at the bottom of the sealed cover shell 2, a gas sensor is provided on one side of the sealing groove 2, and the gas sensor is fixed on the bottom of the sealed cover shell 2.

[0013] According to the above technical solution, the transmission mechanism includes a transmission component and a flow guide component, wherein:

[0014] The transmission assembly comprises a transmission shell fixed on the top of the housing, and a conveyor belt is arranged inside the transmission shell;

[0015] The guide assembly includes a mounting frame and a connecting seat, the mounting frame is fixed to the transmission shell, two groups of guide plates are fixed on the mounting frame, the two groups of guide plates are arranged up and down, a mounting plate 1 is fixed on the connecting seat, a mounting plate 2 is fixedly connected to the side of the mounting plate 1 close to the conveyor belt, a rotating shaft 1 is connected to the bearing on the mounting plate 2, a guide column is fixed on the rotating shaft 1, the guide column is located on one side of the guide plate, a gap is formed between the guide column and the guide plate, the gap is arranged above the conveyor belt, and a rubber pad is fixed on the surface of the guide column.

[0016] According to the above technical solution, a first motor is arranged at the bottom of the shell, a mounting block is fixed at the bottom of the mounting plate 2, the first motor is fixed below the mounting block, and the output end of the first motor is fixedly connected to the rotating shaft 1.

[0017] According to the above technical solution, the rotating assembly includes a mounting base fixed on the bottom of the shell and a plurality of support rods fixed on the top of the shell, a second motor is fixed on the mounting base, a support plate is fixed on the top of the plurality of support rods, a rotating shaft 2 is connected to the middle bearing of the support plate, an output end of the second motor is fixedly connected to the rotating shaft 2, a bearing platform, a rotating disk 1 and a rotating disk 2 are fixed to the rotating shaft 2 in sequence from bottom to top, the bearing platform is arranged on the support plate, a limiting groove 1 is provided on the rotating disk 1, a plurality of limiting grooves 2 are provided on the rotating disk 2, and freeze-dried medicine bottles are placed on the limiting grooves 1 and 2.

[0018] According to the above technical solution, roller one is arranged on both sides of each group of limit grooves one, and roller one is arranged above rotating disk one, and roller two is arranged on both sides of each group of limit grooves two, and roller two is arranged below rotating disk two.

[0019] According to the above technical solution, the lifting assembly includes a connecting shell 1 fixed on the shell, a side plate is fixed on one side of the connecting shell 1, a lifting block is slidably connected to one side of the side plate, a sliding rod is slidably connected to the lifting block, a screw transmission assembly is arranged inside the connecting shell 1, the screw transmission assembly is fixedly connected to the lifting block, a slide groove 1 is provided on one side of the connecting shell 1 close to the side plate, a slide groove 2 is provided on the side plate, the slide groove 1 corresponds to the slide groove 2, and the lifting block runs through the slide groove 1 and the slide groove 2;

[0020] A connecting shell 2 is fixed to one side of the connecting shell 1, and a camera is fixed to one side of the connecting shell 2 close to the rotating component.

[0021] According to the above technical solution, the cleaning assembly includes a fixed seat 1, the fixed seat 1 is fixed on the lifting block, a central block is fixed at the bottom of the fixed seat 1, two sets of fixed rods are fixed on the central block, a slide plate 1 is slidably connected to the fixed rod, a slide plate 2 is fixed on the fixed rod, the slide plate 1 is arranged above the slide plate 2, a bending plate is fixed on the slide plate 1, and the bending plate is fixedly connected to the slide rod;

[0022] Two groups of push rods are fixed under the second slide plate, and the push rods are slidably connected to the bottom of the central block. A central plate is fixed to the end of the push rod, a sleeve is fixed to the bottom of the central plate, and a rubber column is fixed at the center of the sleeve. The diameter of the rubber column is consistent with the diameter of the bottle mouth of the freeze-dried medicine bottle.

[0023] According to the above technical solution, a ventilation duct and a sealing chamber are provided inside the hollow cylinder, the sealing chamber is provided outside the ventilation duct, a piston is slidably provided inside the sealing chamber, a sealing sleeve is fixed to one end of the piston, the sealing sleeve is sleeved on the outside of the ventilation duct, the sealing sleeve and the ventilation duct have the same axis, the end of the sealing sleeve is connected to a sealing cover shell, the inflation tube is connected to the ventilation duct, and two groups of air ports are provided on the outside of the sealing chamber.

[0024] A method for detecting sealing process defects for freeze-dried drug bottles, comprising:

[0025] Method 1: Move the freeze-dried medicine bottle to the rotating disk 2 and the rotating disk 1 through the conveyor belt, then control the rotating disk 2 to rotate, start the screw transmission assembly to drive the lifting block to move downward, so that the sleeve is sleeved on the bottle mouth of the freeze-dried medicine bottle, and the impurities on the surface of the bottle mouth of the freeze-dried medicine bottle are cleaned to improve the accuracy of subsequent sealing detection;

[0026] Method 2: After the surface of the mouth of the freeze-dried medicine bottle is cleaned, the rotating disk 2 and the rotating disk 1 are controlled to rotate again, and then the freeze-dried medicine bottle is driven to rotate to the bottom of the inflation component, and the air tightness of the freeze-dried medicine bottle under low temperature is tested by the inflation component;

[0027] Method 3: After the low-temperature test is completed, a subsequent air tightness test is performed under high temperature conditions to determine the quality of the freeze-dried drug bottle;

[0028] Method 4: After the freeze-dried drug bottles are inspected, the freeze-dried drug bottles are moved to the conveyor belt through the guide assembly.

[0029] According to the above technical solution, the second method includes the following specific steps:

[0030] Method 2-a: When the freeze-dried drug bottle is tested at low temperature, the surface of the freeze-dried drug bottle is cleaned by the extrusion component to ensure the cleanliness of the bottle surface. When cleaning the surface of the freeze-dried drug bottle, it is further determined whether the freeze-dried drug bottle has cracks, so as to determine the quality of the freeze-dried drug bottle at low temperature;

[0031] Method 2-b: While detecting whether cracks are generated in the freeze-dried medicine bottle at low temperature, a pressure gauge 1 detects the air pressure on the inflation tube 1 in real time to further determine the sealing performance of the bottle mouth of the freeze-dried medicine bottle.

[0032] Compared with the prior art, the beneficial effects achieved by the present invention are as follows: the present invention, by providing an inflation component and an extrusion component, can use low temperature and high temperature successively when inflating to detect the air tightness, judge the air tightness of the freeze-dried medicine bottle at different temperatures, and at the same time clean the surface of the freeze-dried medicine bottle. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0034] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0035] Figure 2 The overall structure of the present invention is schematically shown in FIG. Figure 1 ;

[0036] Figure 3 It is a front schematic diagram of the overall structure of the present invention;

[0037] Figure 4 The overall structure of the present invention is schematically shown in FIG. Figure 2 ;

[0038] Figure 5 The present invention Figure 1 A local enlarged schematic diagram of area A;

[0039] Figure 6 The present invention Figure 1 A local enlarged schematic diagram of area B;

[0040] Figure 7 The present invention Figure 1 A local enlarged schematic diagram of the C region;

[0041] Figure 8 The present invention Figure 3 A local enlarged schematic diagram of the D region;

[0042] Fig. 9 is a two-dimensional schematic diagram of a hollow cylinder of the present invention;

[0043] Fig.10 is a two-dimensional schematic diagram of the central tube of the present invention;

[0044] Fig.11 is a two-dimensional schematic diagram of the sealing cover of the present invention;

[0045] Fig.12 is a two-dimensional schematic diagram of the sleeve of the present invention;

[0046] In the figure: 1, shell; 2, control platform; 3, conveyor belt; 4, mounting frame; 5, transmission shell; 6, mounting plate 1; 7, mounting plate 2; 8, guide column; 9, connecting seat; 10, guide plate; 11, rubber pad; 12, first motor; 13, mounting block; 14, gap; 15, mounting seat; 16, support rod; 17, support plate; 18, bearing platform; 19, rotating disk 1; 20, rotating disk 2; 21, limit groove 1; 22, limit groove 2; 23, second motor; 24, electric telescopic rod 1; 25, mounting rod; 26, connecting block; 27, support column; 28, lifting rod; 29, brush plate; 30, brush head; 31, connecting shell 1; 32, side plate; 33, lifting block; 34, fixing seat 1; 35, central block; 36, fixing rod; 3 7. Slide plate one; 38. Bending plate; 39. Slide plate two; 40. Push rod; 41. Central plate; 42. Sleeve; 43. Rubber column; 44. Inflatable tank; 45. Inflatable tube one; 46. Fixed seat two; 47. Hollow cylinder; 48. Barometer one; 49. First air pump; 50. Sealing cover shell one; 51. Connecting frame; 52. Electric telescopic rod two; 53. Sealing cover shell two; 54. Inflatable tube two; 55. Barometer two; 56. Second air pump; 57. Connecting shell two; 58. Camera; 59. Sliding rod; 60. Sealing chamber; 61. Piston; 62. Ventilation duct; 63. Sealing sleeve; 64. Through hole; 65. Lighting lamp; 66. Central tube; 67. Sealing groove one; 68. Gas sensor; 69. Sealing groove two; 70. Roller one; 71. Roller two. DETAILED DESCRIPTION

[0047] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0048] See also Figure 1-12 The present invention provides a technical solution: a sealing process defect detection device for freeze-dried medicine bottles, comprising a shell 1, a transmission mechanism, a rotating mechanism, and a detection mechanism. The transmission mechanism is arranged on the left side of the shell 1 and is used to transport the freeze-dried medicine bottles. The rotating mechanism is arranged in the middle of the shell 1 and is used to move the freeze-dried medicine bottles on the transmission mechanism to the bottom of the detection mechanism. The detection mechanism is located in front of the shell 1. When the freeze-dried medicine bottles are moved to the bottom of the detection mechanism, the sealing of the freeze-dried medicine bottles is detected.

[0049] A control platform 2 is disposed on the rear side of the housing 1 .

[0050] The transmission mechanism includes a transmission component and a guide component. The transmission component includes a transmission shell 5 fixed on the top of the housing 1. A conveyor belt 3 is arranged inside the transmission shell 5. The freeze-dried medicine bottles are placed on the conveyor belt 3 for transmission.

[0051] The guide assembly includes a mounting frame 4 and a connecting seat 9. The mounting frame 4 is fixed to the transmission housing 5. Two groups of guide plates 10 are fixed on the mounting frame 4. The two groups of guide plates 10 are arranged up and down. A mounting plate 1 6 is fixed on the connecting seat 9. A mounting plate 2 7 is fixedly connected to the side of the mounting plate 1 6 close to the conveyor belt 3. A rotating shaft 1 (not shown in the figure) is connected to the bearing on the mounting plate 2 7. A guide column 8 is fixed on the rotating shaft 1. The guide column 8 is located on one side of the guide plate 10. A gap 14 is formed between the guide column 8 and the guide plate 10. The gap 14 is arranged above the conveyor belt 3. A rubber pad 11 is fixed on the surface of the guide column 8. When the freeze-dried drug bottle passes through the gap 14, the friction can be increased by the rubber pad 11.

[0052] A first motor 12 is provided at the bottom of the shell 1, and a mounting block 13 is fixed to the bottom of the mounting plate 7. The first motor 12 is fixed below the mounting block 13, and the output end of the first motor 12 is fixedly connected to the rotating shaft 1. When the first motor 12 is started, the guide column 8 is driven to rotate through the rotating shaft 1, and the freeze-dried medicine bottle is moved to the conveyor belt 3 through the gap 14 between the guide plate 10 and the guide column 8.

[0053] The rotating mechanism includes a rotating assembly and an extrusion assembly. The rotating assembly includes a mounting seat 15 fixed at the bottom of the shell 1, and a plurality of support rods 16 fixed at the top of the shell 1. A second motor 23 is fixed on the mounting seat 15. A support plate 17 is fixed on the top of the plurality of support rods 16. A rotating shaft 2 (not shown in the figure) is connected to the intermediate bearing of the support plate 17. The output end of the second motor 23 is fixedly connected to the rotating shaft 2. The rotating shaft 2 is fixed with a bearing platform 18, a rotating disk 19 and a rotating disk 20 in sequence from bottom to top. The bearing platform 18 is arranged on the supporting plate 17. A limiting groove 1 21 is provided on the rotating disk 19. A plurality of limiting grooves 22 are provided on the rotating disk 20. Freeze-dried medicine bottles are placed on the limiting grooves 1 21 and the limiting grooves 2 22. The second motor 23 is started to drive the rotating shaft 2 to rotate, thereby driving the bearing platform 18, the rotating disk 1 19 and the rotating disk 2 20 to rotate, and then driving the freeze-dried medicine bottles to rotate.

[0054] Roller 1 70 is disposed on both sides of each set of limiting groove 1 21 , and roller 1 70 is disposed above rotating disk 1 19 . Roller 2 71 is disposed on both sides of each set of limiting groove 22 , and roller 2 71 is disposed below rotating disk 20 .

[0055] The extrusion assembly includes an electric telescopic rod 24 and a mounting rod 25 fixed on the housing 1. The electric telescopic rod 24 and the mounting rod 25 are both provided with two groups. The two groups of electric telescopic rods 24 are provided on one side of the rotating assembly. The two groups of electric telescopic rods 24 are slidably connected with a lifting rod 28. The output ends of the two groups of electric telescopic rods 24 are fixedly connected to the lifting rod 28. When the electric telescopic rod 24 is started to extend and retract, the lifting rod 28 is driven to move up and down.

[0056] The lifting rod 28 is connected to a plurality of connecting blocks 26 through a telescopic drive, a brush plate 29 is fixed to the connecting block 26, and a plurality of brush heads 30 are provided on the brush plate 29. The brush heads 30 are in contact with the surface of the freeze-dried medicine bottle. It should be added that the telescopic drive can be a pneumatic cylinder or an electric telescopic cylinder.

[0057] The detection mechanism includes a lifting component, an inflation component and a cleaning component. The lifting component includes a connecting shell 31 fixed on the shell 1, a side plate 32 is fixed on one side of the connecting shell 31, a lifting block 33 is slidably connected to one side of the side plate 32, and a sliding rod 59 is slidably connected to the lifting block 33. A screw transmission component is arranged inside the connecting shell 31, and the screw transmission component is fixedly connected to the lifting block 33. A slide groove 1 (not shown in the figure) is provided on the side of the connecting shell 31 close to the side plate 32, and a slide groove 2 (not shown in the figure) is provided on the side plate 32. The slide groove 1 corresponds to the slide groove 2, and the lifting block 33 runs through the slide groove 1 and the slide groove 2. The screw transmission component is started to drive the lifting block 33 to slide on the sliding rod 59;

[0058] A second connection shell 57 is fixed to one side of the first connection shell 31 , and a camera 58 is fixed to one side of the second connection shell 57 close to the rotating assembly.

[0059] The cleaning assembly includes a fixing seat 1 34, which is fixed on the lifting block 33, a central block 35 is fixed at the bottom of the fixing seat 1 34, two sets of fixing rods 36 are fixed on the central block 35, a slide plate 1 37 is slidably connected to the fixing rod 36, a slide plate 2 39 is fixed on the fixing rod 36, the slide plate 1 37 is arranged above the slide plate 2 39, a bending plate 38 is fixed on the slide plate 1 37, and the bending plate 38 is fixedly connected to the sliding rod 59;

[0060] Two sets of push rods 40 are fixed below the slide plate 39. The push rods 40 are slidably connected to the bottom of the central block 35. A central plate 41 is fixed to the end of the push rods 40. A sleeve 42 is fixed to the bottom of the central plate 41. A rubber column 43 (such as Fig.12 As shown in the figure, the diameter of the rubber column 43 is consistent with the diameter of the mouth of the freeze-dried medicine bottle. When the lifting block 33 is lifted or lowered, the central block 35 is driven to move downward, thereby driving the slide plate 2 39 to move downward, so that the push rod 40 moves downward, driving the sleeve 42 to contact the mouth of the freeze-dried medicine bottle, and inserting the rubber column 43 into the mouth of the freeze-dried medicine bottle;

[0061] It should be added that, since the slide plate 37 is fixed by the bending plate 38 and the slide rod 59, the fixing rod 36 slides on the slide plate 37 when the central block 35 moves downward, and the central block 35 can be limited by the slide plate 37.

[0062] The inflation component includes an inflation tank 44 fixed on the shell 1, a fixing seat 46 and a support column 27 fixed on the shell 1. A low-temperature gas cavity and a high-temperature gas cavity (not shown in the figure) are arranged inside the inflation tank 44. An inflation tube 45 is connected to the low-temperature gas cavity. A hollow cylinder 47 is fixed on the fixing seat 46. The top of the hollow cylinder 47 is connected to the inflation tube 45. A pressure gauge 48 and a first air pump 49 are connected to the inflation tube 45. A sealing cover 50 is fixed to the output end of the hollow cylinder 47. The sealing cover 50 is located above the freeze-dried medicine bottle. The hollow cylinder 47 is controlled to extend so that the sealing cover 50 covers the bottle mouth of the freeze-dried medicine bottle. The first air pump 49 is started to pump the gas in the inflation tank 44 into the sealing cover 50 through the inflation tube 45 and then into the freeze-dried medicine bottle, and the air pressure on the inflation tube 45 is detected by the pressure gauge 48.

[0063] A connecting frame 51 is fixed to the top of the support column 27, and an electric telescopic rod 2 52 is fixed on the connecting frame 51. A sealing cover shell 2 53 is fixed to the output end of the electric telescopic rod 2 52. An inflation tube 2 54 is connected to one side of the sealing cover shell 53. The other end of the inflation tube 2 54 is connected to the high-temperature gas chamber. A pressure gauge 2 55 and a second air pump 56 are connected to the inflation tube 2 54 in sequence. The pressure gauge 1 48, the pressure gauge 2 55 and the camera 58 are electrically connected to the control platform 2.

[0064] A ventilation passage 62 and a sealing chamber 60 are arranged inside the hollow cylinder 47. The sealing chamber 60 is arranged outside the ventilation passage 62. A piston 61 is slidably arranged inside the sealing chamber 60. A sealing sleeve 63 is fixed at one end of the piston 61. The sealing sleeve 63 is sleeved on the outside of the ventilation passage 62. The sealing sleeve 63 and the ventilation passage 62 are coaxial. The end of the sealing sleeve 63 is connected to the sealing cover 50. The inflation tube 45 is connected to the ventilation passage 62. Two groups of gas ports are arranged on the outside of the sealing chamber 60 for introducing external gas into the sealing chamber 60 to push the piston 61 to move in the sealing chamber 60, thereby controlling the elongation of the sealing sleeve 63.

[0065] A central tube 66 is connected through the bottom of the sealed cover shell 1 50, a plurality of through holes 64 are provided on the outside of the central tube 66, a plurality of lighting lamps 65 are fixed on the outside of the central tube 66, a sealing groove 1 67 is provided at the bottom of the sealed cover shell 1 50, a sealing groove 2 69 is provided at the bottom of the sealed cover shell 2 53, a gas sensor 68 is provided on one side of the sealing groove 2 69, and the gas sensor 68 is fixed on the bottom of the sealed cover shell 2 53.

[0066] A method for detecting sealing process defects for freeze-dried drug bottles includes:

[0067] Method 1: Move the freeze-dried medicine bottle to the rotating disk 20 and the rotating disk 1 19 through the conveyor belt 3, then control the rotating disk 20 to rotate, start the screw transmission assembly to drive the lifting block 33 to move downward, so that the sleeve 42 is sleeved on the bottle mouth of the freeze-dried medicine bottle, and the impurities on the surface of the bottle mouth of the freeze-dried medicine bottle are cleaned, thereby improving the accuracy of subsequent sealing detection;

[0068] Method 2: After the surface of the mouth of the freeze-dried medicine bottle is cleaned, the rotating disk 20 and the rotating disk 19 are controlled to rotate again, and then the freeze-dried medicine bottle is driven to rotate to the bottom of the inflation component, and the air tightness of the freeze-dried medicine bottle under low temperature is tested by the inflation component;

[0069] Specifically, when the lifting block 33 is lowered to a certain extent, the hollow cylinder 47 is started to extend so that the central tube 66 enters into the freeze-dried medicine bottle, so that the sealing cover shell 50 covers the bottle mouth of the freeze-dried medicine bottle, and the sealing groove 67 clamps the bottle mouth of the freeze-dried medicine bottle to ensure the sealing. The first air pump 49 is started to pump the gas in the low-temperature gas cavity into the central tube 66 through the inflation tube 45, and enters the interior of the freeze-dried medicine bottle through the through hole 64. At this time, the air pressure on the inflation tube 45 is detected by the pressure gauge 48, and the air pressure data is transmitted to the control platform 2. The maximum air pressure value is set in the control platform 2. When the air pressure reaches the set air pressure value, no more air is introduced, and the pressure is kept constant for a period of time. During the constant pressure process, if the pressure of the pressure gauge 48 becomes smaller, it means that the sealing of the freeze-dried medicine bottle is poor.

[0070] Method 3: After the low-temperature test is completed, a subsequent air tightness test is performed under high temperature conditions to determine the quality of the freeze-dried drug bottle;

[0071] Specifically, during high-temperature detection, the freeze-dried medicine bottle is moved to the bottom of the sealed cover shell 53 by controlling the rotation of the rotating disk 20 and the rotating disk 19, and the electric telescopic rod 52 is started to extend so that the sealing groove 69 on the sealed cover shell 53 covers the bottle mouth of the freeze-dried medicine bottle. At this time, the second air pump 56 is started to pump the high-temperature gas in the high-temperature gas chamber into the freeze-dried medicine bottle through the inflation tube 54. The air pressure on the inflation tube 54 is detected by the barometer 55 and transmitted to the control platform 2. When the air pressure reaches the set air pressure, the constant pressure is maintained for a period of time to judge the change in the air pressure value. When the air pressure decreases, it means that the air tightness of the freeze-dried medicine bottle under the high-temperature gas is poor.

[0072] Method 4: After the freeze-dried medicine bottles are inspected, the freeze-dried medicine bottles are moved to the conveyor belt 3 through the guide assembly;

[0073] Specifically, the rotating disk 20 and the rotating disk 19 are controlled to rotate again to move the freeze-dried medicine bottle to the guide column 8, and the first motor 12 is started to drive the guide column 8 to rotate. The freeze-dried medicine is moved from the limiting groove 1 21 and the limiting groove 2 22 to the gap 14 through the friction of the rubber pad 11, and then further moved to the conveyor belt 3 to transmit the freeze-dried medicine bottle.

[0074] It should be noted that when the rotating disk 20 and the rotating disk 19 rotate to drive the freeze-dried medicine bottle to move, the brush head 30 is always in contact with the surface of the freeze-dried medicine bottle to prevent the freeze-dried medicine bottle from falling, and because the roller 1 70 and the roller 2 71 are provided, when the freeze-dried medicine bottle follows the rotation, the cooperation of the roller 1 70 and the roller 2 71 with the brush head 30 can control the freeze-dried medicine bottle to rotate in the limiting groove 1 21 and the limiting groove 22, so that the other surfaces of the freeze-dried medicine bottle are in contact with the brush head 30, so as to better clean the surface of the freeze-dried medicine bottle and improve the cleaning efficiency.

[0075] Method 2 includes the following specific steps:

[0076] Method 2-a: When the freeze-dried drug bottle is tested at low temperature, the surface of the freeze-dried drug bottle is cleaned by the extrusion component to ensure the cleanliness of the bottle surface. When cleaning the surface of the freeze-dried drug bottle, it is further determined whether the freeze-dried drug bottle has cracks, so as to determine the quality of the freeze-dried drug bottle at low temperature;

[0077] Specifically, when there is no air leakage during the constant pressure process, the lighting lamp 65 is turned on to illuminate the inside of the freeze-dried medicine bottle to make the freeze-dried medicine bottle transparent, and the external camera 58 is used to detect whether there are cracks on the surface of the freeze-dried medicine bottle, and the signal is transmitted to the control platform 2 to be recorded and marked as the first image. At this time, the electric telescopic rod 24 is started to extend so that the brush head 30 moves on the surface of the freeze-dried medicine bottle, which can clean the impurities on the surface of the freeze-dried medicine bottle and ensure the cleanliness of the surface of the freeze-dried medicine bottle;

[0078] When the brush head 30 moves on the surface of the freeze-dried medicine bottle, the telescopic drive is controlled to extend so that the brush head 30 is close to the surface of the freeze-dried medicine bottle for squeezing. The camera 58 is used again to detect whether there are cracks on the surface of the freeze-dried medicine bottle, and the image is marked as the second image through the control platform 2. The first image is compared with the second image. When there are no cracks in the first image and cracks in the second image, it means that cracks are generated in the freeze-dried medicine bottle when squeezed by the brush head 30, indicating that the freeze-dried medicine bottle is prone to problems under low temperature conditions. The freeze-dried medicine bottle is marked as Q. When there are cracks in the first image, no subsequent squeezing work is required and it can be directly removed. When there are no cracks in both the first image and the second image, it indicates that the freeze-dried medicine bottle is not affected under low temperature conditions, and the freeze-dried medicine bottle is marked as W.

[0079] Method 2-b: While detecting whether cracks are generated in the freeze-dried medicine bottle at low temperature, the pressure gauge 48 detects the air pressure on the inflation tube 45 in real time to further determine the sealing performance of the bottle mouth of the freeze-dried medicine bottle;

[0080] Specifically, when the air pressure of the freeze-dried drug bottle marked as Q becomes low, it means that the freeze-dried drug bottle is of poor quality and can be directly removed. If the air pressure of the freeze-dried drug bottle marked as Q does not change, it can enter the next process;

[0081] When the air pressure of a freeze-dried medicine bottle marked as W becomes low, the freeze-dried medicine bottle will be marked as yellow W. If the air pressure of the freeze-dried medicine bottle marked as W does not change, it means that the quality of the freeze-dried medicine bottle is good under low temperature conditions and subsequent high-temperature testing can be carried out.

[0082] Method 3 includes the following specific steps:

[0083] Method 3-a: When the sealing performance of the freeze-dried drug bottle is poor under high-temperature gas, the quality of the freeze-dried drug bottle is judged in combination with low-temperature gas detection;

[0084] Specifically, when the air pressure of the freeze-dried medicine bottle marked as W drops under the condition of high-temperature gas detection, if the gas sensor 68 does not detect gas, it means that the freeze-dried medicine bottle is broken when the low-temperature to high-temperature transition is performed, indicating that the quality of the freeze-dried medicine bottle is poor. If the gas sensor 68 detects gas, it means that the mouth of the freeze-dried medicine bottle is deformed, resulting in a crack between the sealing cover 2 53 and the mouth of the freeze-dried medicine bottle, thereby gas leakage;

[0085] When the freeze-dried drug bottle marked with yellow W does not drop in pressure during high-temperature gas detection, it proves that the mouth of the freeze-dried drug bottle is deformed during low-temperature gas detection. During high-temperature gas detection, the freeze-dried drug bottle recovers due to the influence of temperature, indicating that there is a problem with the freeze-dried drug bottle in the low-temperature gas state. At this time, the freeze-dried drug bottle is marked to facilitate subsequent staff to deal with it;

[0086] It should be added that in subsequent work, low-temperature air pressure detection and high-temperature air pressure detection can be carried out simultaneously to improve the detection timeliness. When the extrusion component is working, low-temperature gas and high-temperature gas can be squeezed at the same time to detect the freeze-dried medicine bottle. When the high-temperature gas is detected and the gas in the freeze-dried medicine bottle is not leaking, the air pressure detected by the pressure gauge 2 55 suddenly increases when the extrusion component is working, indicating that the gas inside the freeze-dried medicine bottle is squeezed into the inflation tube 2 54, causing the air pressure detected by the pressure gauge 2 55 to increase, indicating that the freeze-dried medicine bottle has a large degree of deformation under high temperature conditions, indicating that the plasticity of the freeze-dried medicine bottle is poor.

[0087] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0088] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A sealing process defect detection device for freeze-dried drug bottles, comprising a housing (1), a transmission mechanism, a rotation mechanism, and a detection mechanism, characterized in that: The transport mechanism is arranged on the left side of the housing (1) and is used to transport freeze-dried medicine bottles. The rotating mechanism is arranged in the middle of the housing (1) and is used to move the freeze-dried medicine bottles on the transport mechanism to below the detection mechanism. The detection mechanism is located in front of the housing (1) and detects the sealing of the freeze-dried medicine bottles when the freeze-dried medicine bottles move to below the detection mechanism. The rotating mechanism comprises a rotating assembly and an extruding assembly, wherein: The extrusion assembly comprises an electric telescopic rod (24) and a mounting rod (25) fixed on the housing (1), the electric telescopic rod (24) and the mounting rod (25) are each provided in two groups, the two groups of the electric telescopic rod (24) being provided on one side of the rotating assembly, the two groups of the electric telescopic rod (24) being slidably connected to a lifting rod (28), and the output ends of the two groups of the electric telescopic rod (24) being fixedly connected to the lifting rod (28); The lifting rod (28) is connected to a plurality of connection blocks (26) via a telescopic drive, a brush plate (29) is fixed to the connection block (26), and a plurality of brush heads (30) are arranged on the brush plate (29); The detection mechanism includes a lifting component, an inflation component and a cleaning component, wherein: The inflation component comprises an inflation tank (44) fixed on the shell (1), a second fixing seat (46) and a support column (27) fixed on the shell (1); a low-temperature gas cavity and a high-temperature gas cavity are arranged inside the inflation tank (44); an inflation tube (45) is connected to the low-temperature gas cavity; a hollow cylinder (47) is fixed to the second fixing seat (46); the top of the hollow cylinder (47) is connected to the inflation tube (45); a pressure gauge (48) and a first air pump (49) are connected to the inflation tube (45); a sealing cover (50) is fixed to the output end of the hollow cylinder (47); the sealing cover (50) is located above the freeze-dried medicine bottle; A connecting frame (51) is fixed to the top of the support column (27), a second electric telescopic rod (52) is fixed to the connecting frame (51), a second sealing cover (53) is fixed to the output end of the second electric telescopic rod (52), a second inflation tube (54) is connected to one side of the second sealing cover (53), the other end of the second inflation tube (54) is connected to the high-temperature gas chamber, and a second pressure gauge (55) and a second air pump (56) are connected to the second inflation tube (54) in sequence; A central tube (66) is connected through the bottom of the sealing cover shell 1 (50), a plurality of through holes (64) are provided on the outside of the central tube (66), a plurality of lighting lamps (65) are fixed on the outside of the central tube (66), a sealing groove 1 (67) is provided at the bottom of the sealing cover shell 1 (50), a sealing groove 2 (69) is provided at the bottom of the sealing cover shell 2 (53), a gas sensor (68) is provided on one side of the sealing groove 2 (69), and the gas sensor (68) is fixed on the bottom of the sealing cover shell 2 (53).

2. The sealing process defect detection device for freeze-dried drug bottles according to claim 1 is characterized in that: The transmission mechanism includes a transmission component and a flow guide component, wherein: The transmission assembly comprises a transmission shell (5) fixed on the top of the housing (1), and a conveyor belt (3) is arranged inside the transmission shell (5); The guide assembly comprises a mounting frame (4) and a connecting seat (9), wherein the mounting frame (4) is fixed to a transmission housing (5), and two groups of guide plates (10) are fixed to the mounting frame (4), and the two groups of guide plates (10) are arranged up and down, and a mounting plate 1 (6) is fixed to the connecting seat (9), and a mounting plate 2 (7) is fixedly connected to a side of the mounting plate 1 (6) close to the conveyor belt (3), and a rotating shaft 1 is connected to a bearing on the mounting plate 2 (7), and a guide column (8) is fixed to the rotating shaft 1, and the guide column (8) is located on one side of the guide plate (10), and a gap (14) is formed between the guide column (8) and the guide plate (10), and the gap (14) is arranged above the conveyor belt (3), and a rubber pad (11) is fixed to the surface of the guide column (8).

3. The sealing process defect detection device for freeze-dried drug bottles according to claim 2 is characterized in that: A first motor (12) is arranged at the bottom of the housing (1), a mounting block (13) is fixed at the bottom of the second mounting plate (7), the first motor (12) is fixed below the mounting block (13), and an output end of the first motor (12) is fixedly connected to the first rotating shaft.

4. The sealing process defect detection device for freeze-dried drug bottles according to claim 3 is characterized in that: The rotating assembly comprises a mounting seat (15) fixed to the bottom of the shell (1), and a plurality of support rods (16) fixed to the top of the shell (1); a second motor (23) is fixed to the mounting seat (15); a support plate (17) is fixed to the top of the plurality of support rods (16); a second rotating shaft (2) is connected to the middle bearing of the support plate (17); an output end of the second motor (23) is fixedly connected to the second rotating shaft; a bearing platform (18), a first rotating disk (19) and a second rotating disk (20) are fixed to the second rotating shaft in sequence from bottom to top; the bearing platform (18) is arranged on the support plate (17); a first limiting groove (21) is provided on the first rotating disk (19); a plurality of second limiting grooves (22) are provided on the second rotating disk (20); freeze-dried medicine bottles are placed on the first limiting groove (21) and the second limiting groove (22).

5. The sealing process defect detection device for freeze-dried drug bottles according to claim 4 is characterized in that: Each group of the limiting grooves (21) is provided with rollers (70) on both sides, and the rollers (70) are arranged above the rotating disk (19); each group of the limiting grooves (22) is provided with rollers (71) on both sides, and the rollers (71) are arranged below the rotating disk (20).

6. The sealing process defect detection device for freeze-dried drug bottles according to claim 5, characterized in that: The lifting assembly comprises a connecting shell (31) fixed on the shell (1), a side plate (32) being fixed on one side of the connecting shell (31), a lifting block (33) being slidably connected to one side of the side plate (32), a sliding rod (59) being slidably connected to the lifting block (33), a screw transmission assembly being arranged inside the connecting shell (31), the screw transmission assembly being fixedly connected to the lifting block (33), a sliding groove (1) being provided on a side of the connecting shell (31) close to the side plate (32), a sliding groove (2) being provided on the side plate (32), the sliding groove (1) corresponding to the sliding groove (2), and the lifting block (33) passing through the sliding groove (1) and the sliding groove (2); A second connection shell (57) is fixed to one side of the first connection shell (31), and a camera (58) is fixed to the side of the second connection shell (57) close to the rotating assembly.

7. The sealing process defect detection device for freeze-dried drug bottles according to claim 6 is characterized in that: The cleaning assembly comprises a fixing seat 1 (34), wherein the fixing seat 1 (34) is fixed on a lifting block (33), a central block (35) is fixed at the bottom of the fixing seat 1 (34), two sets of fixing rods (36) are fixed on the central block (35), a slide plate 1 (37) is slidably connected to the fixing rods (36), a slide plate 2 (39) is fixed to the fixing rods (36), the slide plate 1 (37) is arranged above the slide plate 2 (39), a bending plate (38) is fixed on the slide plate 1 (37), and the bending plate (38) is fixedly connected to the sliding rod (59); Two groups of push rods (40) are fixed below the second slide plate (39), and the push rods (40) are slidably connected to the bottom of the central block (35). A central plate (41) is fixed to the end of the push rod (40), and a sleeve (42) is fixed to the bottom of the central plate (41). A rubber column (43) is fixed at the center of the sleeve (42), and the diameter of the rubber column (43) is consistent with the diameter of the mouth of the freeze-dried medicine bottle.

8. The sealing process defect detection device for freeze-dried drug bottles according to claim 7, characterized in that: The hollow cylinder (47) is provided with a ventilation duct (62) and a sealing chamber (60) inside. The sealing chamber (60) is provided outside the ventilation duct (62). A piston (61) is slidably provided inside the sealing chamber (60). A sealing sleeve (63) is fixed to one end of the piston (61). The sealing sleeve (63) is sleeved on the outside of the ventilation duct (62). The sealing sleeve (63) and the ventilation duct (62) are coaxial. The end of the sealing sleeve (63) is connected to a sealing cover shell (50). The inflation tube (45) is connected to the ventilation duct (62). Two groups of air ports are provided on the outside of the sealing chamber (60).

9. A method for detecting sealing process defects for freeze-dried drug bottles, according to the device for detecting sealing process defects for freeze-dried drug bottles according to claim 8, characterized in that: include: Method 1: Move the freeze-dried medicine bottle to the rotating disk 2 (20) and the rotating disk 1 (19) via the conveyor belt (3), then control the rotating disk 2 (20) to rotate, start the screw transmission assembly to drive the lifting block (33) to move downward, so that the sleeve (42) is sleeved on the bottle mouth of the freeze-dried medicine bottle, and the impurities on the surface of the bottle mouth of the freeze-dried medicine bottle are cleaned, thereby improving the accuracy of subsequent sealing detection; Method 2: After the surface of the freeze-dried drug bottle is cleaned, the second rotating disk (20) and the first rotating disk (19) are controlled to rotate again, thereby driving the freeze-dried drug bottle to rotate to the bottom of the inflation component, and the air tightness of the freeze-dried drug bottle under low temperature is tested by the inflation component; Method 3: After the low-temperature test is completed, a subsequent air tightness test is performed under high temperature conditions to determine the quality of the freeze-dried drug bottle; Method 4: After the freeze-dried drug bottles are inspected, the freeze-dried drug bottles are moved to the conveyor belt (3) through the guide assembly.

10. A method for detecting sealing process defects for freeze-dried drug bottles according to claim 9, characterized in that: The second method comprises the following specific steps: Method 2-a: When the freeze-dried drug bottle is tested at low temperature, the surface of the freeze-dried drug bottle is cleaned by the extrusion component to ensure the cleanliness of the bottle surface. When cleaning the surface of the freeze-dried drug bottle, it is further determined whether the freeze-dried drug bottle has cracks, so as to determine the quality of the freeze-dried drug bottle at low temperature; Method 2-b: While detecting whether cracks are generated in the freeze-dried medicine bottle under low temperature conditions, the pressure gauge 1 (48) detects the air pressure on the inflation tube 1 (45) in real time to further determine the sealing performance of the bottle mouth of the freeze-dried medicine bottle.

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