Evaluation method for filling performance of pharmaceutical powder and pharmaceutical powder filling device

Abstract

The invention provides a pharmaceutical powder filling performance evaluation method and a pharmaceutical powder filling device.The method comprises the steps that the corresponding filling quality of pharmaceutical powder at different filling speeds is obtained, the filling speed is the rotating speed of a rotating assembly in the pharmaceutical powder filling device, and the rotating speed is the rotating speed of the rotating assembly; the filling mass is the mass of the pharmaceutical powder received by the storage device from a feeding assembly in the pharmaceutical powder filling device when the rotating assembly rotates by one circle at the filling speed; for each filling speed, the filling efficiency is calculated according to the filling mass corresponding to the filling speed; a filling speed-filling efficiency curve is determined according to the multiple filling speeds and the filling efficiency corresponding to each filling speed, a critical filling speed is determined according to the filling speed-filling efficiency curve, and the critical filling speed is used for evaluating the filling performance of the pharmaceutical powder filled with the pharmaceutical powder filling device. According to the invention, a quantitative index can be provided for evaluating the dynamic filling performance of the pharmaceutical powder, and the evaluation accuracy is improved.

Description

Technical Field

[0001] The present application relates to the field of pharmaceutical powder filling and evaluation, and in particular, to a pharmaceutical powder filling performance evaluation method and a pharmaceutical powder filling device. Background Art

[0002] Due to the complexity of its ingredients, significant hygroscopicity, poor fluidity and stability, traditional Chinese medicine powders often cause problems such as inaccurate filling, unsmooth filling, and significant differences in filling amounts between different batches of pharmaceutical powders during the filling process. The existing technology uses static parameters such as bulk density, particle size, and angle of repose of pharmaceutical powders to indirectly evaluate whether the pharmaceutical powders can be filled smoothly and the filling performance. These parameters are calculated according to the corresponding formulas based on the basic physical properties of the sample pharmaceutical powders. The filling process is a dynamic flow behavior of the pharmaceutical powders, and static parameters cannot accurately evaluate the filling behavior of the pharmaceutical powders. Summary of the invention

[0003] The purpose of the embodiments of the present application is to provide a method for evaluating the filling performance of pharmaceutical powders and a pharmaceutical powder filling device, so as to provide a quantitative index to evaluate the dynamic filling performance of pharmaceutical powders and improve the evaluation accuracy.

[0004] In a first aspect, the present application provides a method for evaluating the filling performance of pharmaceutical powders, comprising: obtaining the filling masses of pharmaceutical powders corresponding to different filling speeds, wherein the filling speed is the rotation speed of a rotating component in a pharmaceutical powder filling device, and the filling mass is the mass of pharmaceutical powder received by a receiving device from a feeding component in the pharmaceutical powder filling device when the rotating component rotates one circle at the filling speed; for each filling speed, calculating the filling efficiency corresponding to the filling speed according to the filling mass corresponding to the filling speed; determining a filling speed-filling efficiency curve according to multiple filling speeds and the filling efficiencies corresponding to each filling speed, and determining a critical filling speed according to the filling speed-filling efficiency curve, wherein the critical filling speed is used to evaluate the filling performance of the pharmaceutical powder filled by the pharmaceutical powder filling device.

[0005] In the above scheme, the filling quality of pharmaceutical powder at different filling speeds is accurately measured to quantitatively analyze the filling performance of pharmaceutical powder. Since both the filling speed and the filling quality correspond to the dynamic parameters of the pharmaceutical powder during the flow process, more reliable data support can be provided for evaluating the dynamic filling process of the pharmaceutical powder. The filling speed of the pharmaceutical powder will affect the filling efficiency of the pharmaceutical powder, and the filling efficiency can reflect the filling performance of the pharmaceutical powder. Therefore, the critical filling speed determined according to the filling efficiency is used as a quantitative indicator for evaluating the filling performance of the pharmaceutical powder, which can improve the accuracy of the evaluation.

[0006] As an optional method, calculating the filling efficiency corresponding to the filling speed based on the filling mass corresponding to the filling speed includes: determining the quotient of the filling mass corresponding to the filling speed and the complete filling mass as the filling efficiency, wherein the complete filling mass is the mass of the pharmaceutical powder when the storage device is filled.

[0007] In the above scheme, the filling efficiency is calculated based on the mass of the pharmaceutical powder loaded in the storage device, so that the evaluation of the filling performance is more accurate and objective. The calculation of the filling efficiency can help identify the changes in the efficiency of pharmaceutical powder filling at different filling speeds and provide guidance for the design of evaluation indicators.

[0008] As an optional method, the critical filling speed is positively correlated with the filling performance of the pharmaceutical powder. In the above scheme, the filling performance of the pharmaceutical powder can be intuitively evaluated by the quantitative index of the critical filling speed. The larger the value of the critical filling speed, the better the filling performance of the pharmaceutical powder, so that the critical filling speed can become a scientific quantitative standard for evaluating the filling performance of pharmaceutical powder.

[0009] As an optional method, determining the critical filling speed according to the filling speed-filling efficiency curve includes: determining the filling speed corresponding to the target filling efficiency on the filling speed-filling efficiency curve as the critical filling speed. In the above scheme, the critical filling speed is a critical value under the requirement of meeting a specific target filling efficiency. Determining the critical filling speed can help select the most suitable filling speed under the premise of ensuring the filling efficiency, so that the quality of pharmaceutical powder filling in the production process is more stable and predictable.

[0010] In a second aspect, the present application provides a pharmaceutical powder filling device for filling a target pharmaceutical powder into a storage device, the pharmaceutical powder filling device comprising: a rotating component, a driving component, a fixed component and a feeding component; the rotating component is connected to the driving component, the driving component is used to drive the rotating component to rotate around an axis; a sample slot is provided on the rotating component, the sample slot is used to place the storage device, and the opening of the storage device when placed in the sample slot is not higher than the upper surface of the rotating component; the lower surface of the feeding component is in contact with the upper surface of the rotating component and a through hole is provided on the lower surface of the feeding component, the feeding component is used to lay the target pharmaceutical powder, and the through hole is used to fill the target pharmaceutical powder into the storage device when the sample slot rotates to the bottom of the feeding component; the fixed component is used to fix the feeding component so that the feeding component does not rotate with the rotating component.

[0011] As an optional manner, a sealing strip is provided at the portion where the feeding component is in contact with the rotating component, or a sealing strip is provided at the portion where the rotating component is in contact with the feeding component when the pharmaceutical powder filling device is in operation. In the above scheme, the sealing strip can improve the sealing between the feeding component and the rotating component, making the contact between the feeding component and the rotating component tighter and more stable, and preventing the pharmaceutical powder from leaking from the gap during the filling process, thereby reducing material loss and environmental pollution.

[0012] In a third aspect, the present application provides a pharmaceutical powder filling system, comprising: a pharmaceutical powder filling device as described in the second aspect, a storage device and an image acquisition device; the storage device is placed in the sample slot, and the image acquisition device is used to capture an image corresponding to the storage device when the pharmaceutical powder filling device is working.

[0013] In the above scheme, the image acquisition device is used to capture images of the pharmaceutical powder filling status in the storage device when the pharmaceutical powder filling device is working, providing a basis for intuitively evaluating and analyzing the filling performance of the pharmaceutical powder, and also verifying the evaluation effect of the critical filling speed.

[0014] In a fourth aspect, the present application provides a computer program product, comprising computer program instructions, wherein when the computer program instructions are read and executed by a processor, the method described in the first aspect is executed.

[0015] In a fifth aspect, the present application provides an electronic device comprising: a processor, a memory and a bus, wherein the processor and the memory communicate with each other through the bus; the memory stores program instructions that can be executed by the processor, and the processor calls the program instructions to execute the method described in the first aspect.

[0016] In a sixth aspect, the present application provides a computer-readable storage medium, comprising: the computer-readable storage medium stores computer instructions, and the computer instructions enable the computer to execute the method described in the first aspect.

[0017] Other features and advantages of the present application will be described in the subsequent description, and in part will become apparent from the description, or will be understood by implementing the embodiments of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments of the present application will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 A schematic diagram of a process for evaluating the filling performance of pharmaceutical powders provided in an embodiment of the present application; Figure 2 Schematic diagram of the filling speed-filling efficiency curve of the sample pharmaceutical powder S1 in the embodiment of the present application; Figure 3 Schematic diagram of the filling speed-filling efficiency curve of the sample pharmaceutical powder S2 in the embodiment of the present application; Figure 4 It is a schematic diagram of the filling speed-filling efficiency curve of the sample pharmaceutical powder S3 in the embodiment of the present application; Figure 5 A schematic diagram of the structure of a pharmaceutical powder filling device provided in an embodiment of the present application; Figure 6 A front view of a pharmaceutical powder filling device provided in an embodiment of the present application; Figure 7 A top view of a pharmaceutical powder filling device provided in an embodiment of the present application; Figure 8 A front view of a storage device provided in an embodiment of the present application; Fig. 9 A front view of a feeding assembly of a pharmaceutical powder filling device provided in an embodiment of the present application; Fig.10 A schematic diagram of high-speed photography of the filling quality of sample pharmaceutical powders S1, S2, and S3 at different filling speeds in the pharmaceutical powder filling system provided in an embodiment of the present application; Fig.11 A schematic diagram of the structure of an electronic device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0020] The following embodiments of the technical solution of the present application are described in detail in conjunction with the accompanying drawings. The following embodiments are only used to more clearly illustrate the technical solution of the present application, and are therefore only used as examples, and cannot be used to limit the scope of protection of the present application.

[0021] It should be noted that all technical and scientific terms used in this document have the same meanings as those generally understood by technicians in the technical field to which this application belongs; the terms used in this document are only for the purpose of describing specific embodiments and are not intended to limit this application; the terms "including" and "having" in the specification and claims of this application and the above-mentioned figure descriptions and any variations thereof are intended to cover non-exclusive inclusions.

[0022] In the description of the embodiments of the present application, “plurality” means more than two, unless otherwise clearly and specifically defined.

[0023] It can be understood that the evaluation method for the filling performance of pharmaceutical powders provided in the embodiments of the present application can be applied to terminal devices (also referred to as electronic devices) and servers; wherein the terminal devices can specifically be smart phones, tablet computers, computers, personal digital assistants (PDAs), etc.; the servers can specifically be application servers or Web servers.

[0024] For ease of understanding, the technical solution provided in the embodiment of the present application is introduced below using a server as an example of the execution subject to introduce the application scenario of the method for evaluating the filling performance of pharmaceutical powders provided in the embodiment of the present application.

[0025] To facilitate understanding, the professional and technical background involved in the technical solutions provided in the embodiments of the present application is introduced.

[0026] Taking three different batches of fermented Cordyceps powder as sample pharmaceutical powders as an example, the pharmaceutical powder properties of these three batches of sample pharmaceutical powders were measured. The evaluation effect of using angle of repose, bulk density, particle size and water content as indicators for evaluating the filling performance of pharmaceutical powders is analyzed. As described below, a method for measuring angle of repose, bulk density, particle size and water content is provided: Angle of repose α: Determined by the fixed bottom area method of the FT-2000A pharmaceutical powder property tester, select a circular platform with a bottom area of ​​100 mm², a funnel with a 17 mm aperture, fix the stirring blade, and with the feed valve closed, pass the weighed 100.0 g sample pharmaceutical powder through a 1 mm aperture sieve and add it to the funnel. Open the valve and allow it to gradually accumulate on the disc to form a stable cone. Measure the angle between the inclined plane of the material pile and the horizontal plane, which is the angle of repose of the sample pharmaceutical powder. The measurement can be repeated three times in parallel.

[0027] Bulk density Da: Determined by fixed volume method using FT-2000A pharmaceutical powder property tester. Select a 17mm aperture funnel, place an empty 100mL measuring cup on a scale to weigh the mass and peel it, add the sample pharmaceutical powder that has passed through a 1.0mm aperture sieve into the funnel, start feeding until the sample pharmaceutical powder fills the measuring cup and overflows, then stop, scrape the mouth of the measuring cup flat with a scraper, take out the weighed mass M, and calculate Da using the following formula. The measurement can be repeated three times: .

[0028] Particle size D50: Use Malvern Laser Particle Analyzer 2000 dry injection for measurement. Take about 1g of sample pharmaceutical powder and place it in the dry injection device of the laser particle size analyzer. Use air as the dispersion medium and measure the particle size D50 corresponding to when the cumulative particle size distribution number reaches 50%. The measurement can be carried out in parallel three times.

[0029] Water content HR%: Take a dry constant mass weighing bottle with a stopper ( ), add about 2g of sample pharmaceutical powder to the bottle and weigh ( ), and spread it flat on the bottom of the bottle, put it in a 105℃ forced air drying oven to keep constant mass for 5 hours, then take it out and place it at room temperature to weigh the mass, then put it back into the drying oven to keep constant mass for 1 hour, take it out, place it at room temperature to weigh the mass ( ), the water content HR% can be calculated by three parallel measurements using the following formula:

[0030] After measuring the angle of repose, bulk density, particle size and water content of the above three different batches of sample pharmaceutical powders, S1, S2 and S3 are used to refer to the three batches of sample pharmaceutical powders respectively. The measurement results are shown in Table 1:

[0031] Table 1 Table of pharmaceutical powder properties of different batches of samples (mean ± relative error) From the measurement results, it can be seen that there is no significant difference in the angle of repose, bulk density, and water content of the three batches of sample pharmaceutical powders, but there are large differences in the particle size parameters. Therefore, when the differences between the sample pharmaceutical powders are small, the filling performance of the pharmaceutical powders cannot be evaluated based on the measurement of the pharmaceutical powder properties parameters.

[0032] Based on the above analysis, the inventor provides a method for evaluating the filling performance of pharmaceutical powders, which is used to accurately quantify the filling performance of pharmaceutical powders. Figure 1 , Figure 1 A schematic flow chart of a method for evaluating the filling performance of a pharmaceutical powder provided in an embodiment of the present application comprises the following steps: Step S10: Obtain the filling masses of the pharmaceutical powder corresponding to different filling speeds, wherein the filling speed is the rotation speed of the rotating component in the pharmaceutical powder filling device, and the filling mass is the mass of the pharmaceutical powder received by the receiving device from the feeding component in the pharmaceutical powder filling device when the rotating component rotates one circle at the filling speed.

[0033] Specifically, the filling speed may be the linear speed of the center of the receiving device in the rotating assembly of the pharmaceutical powder filling device.

[0034] A certain mass of pharmaceutical powder is naturally spread in the feeding component of the pharmaceutical powder filling device, and a plurality of different filling speeds are selected. The rotating component in the pharmaceutical powder filling device is controlled to rotate at the plurality of filling speeds respectively. During the rotation process, the pharmaceutical powder in the feeding component will be loaded into the receiving device. When the rotating component rotates one circle, the mass of the pharmaceutical powder in the receiving device is recorded to obtain the filling mass corresponding to the current filling speed.

[0035] It should be noted that the prerequisite for evaluating the filling performance of pharmaceutical powders is to fix the pharmaceutical powder filling device, otherwise the critical filling speed that deviates from the pharmaceutical powder filling device will be meaningless. Conversely, a type of pharmaceutical powder can be fixed, and the critical filling speed can be used to evaluate the pharmaceutical powder filling device by changing the parameters of the pharmaceutical powder filling device.

[0036] Also taking the above three batches (S1, S2, S3) of fermented Cordyceps powder as sample pharmaceutical powder as an example, as an implementation method, filling speeds of 10mm / s, 100mm / s, 150mm / s, 200mm / s, 250mm / s, 300mm / s, 350mm / s, 400mm / s and 500mm / s are selected to fill the three batches of sample pharmaceutical powder.

[0037] Step S20: for each filling speed, calculating the filling efficiency corresponding to the filling speed according to the filling mass corresponding to the filling speed.

[0038] The pharmaceutical powder filling device can simulate the pharmaceutical powder filling process in actual industrial production. When the filling speed of the rotating component is different, the amount of pharmaceutical powder that the storage device can receive is also different, corresponding to different filling efficiencies, and there is a functional relationship between the filling speed and the filling efficiency. The filling efficiency calculated according to the filling mass corresponding to the filling speed can be used to compare the filling mass of sample pharmaceutical powder at different filling speeds.

[0039] Step S30: determining a filling speed-filling efficiency curve according to a plurality of filling speeds and the filling efficiency corresponding to each filling speed, and determining a critical filling speed according to the filling speed-filling efficiency curve, wherein the critical filling speed is used to evaluate the filling performance of the pharmaceutical powder filled by the pharmaceutical powder filling device.

[0040] With multiple filling speeds of sample pharmaceutical powders as the horizontal axis and the filling efficiency corresponding to each filling speed as the vertical axis, a filling efficiency and filling speed fitting curve is drawn. The fitted curve is the filling speed-filling efficiency curve (η~V), which can be expressed by a functional relationship. The filling speed-filling efficiency curves fitted for different types of sample pharmaceutical powders and different batches of the same type of sample pharmaceutical powders are different, and the functional relationship is also different.

[0041] In order to study the filling performance of pharmaceutical powders, a filling speed corresponding to a point on the filling speed-filling efficiency curve is selected as the critical filling speed. The selection criteria of the point are determined according to the needs, and those skilled in the art can adjust it according to the actual situation. For example, the filling speed corresponding to the point with a filling efficiency of 50%, 70%, or 100% is used as the critical filling speed. The selected critical filling speed can reflect the maximum filling speed required to fill the target mass of pharmaceutical powder into the storage device. When it is lower than this critical filling speed, the mass of pharmaceutical powder in the storage device is greater than the target mass. When it is higher than this critical filling speed, the mass of pharmaceutical powder in the storage device is less than the target mass.

[0042] In the above scheme, the filling quality of pharmaceutical powder at different filling speeds is accurately measured to quantitatively analyze the filling performance of pharmaceutical powder. Since both the filling speed and the filling quality correspond to the dynamic parameters of the pharmaceutical powder during the flow process, more reliable data support can be provided for evaluating the dynamic filling process of the pharmaceutical powder. The filling speed of the pharmaceutical powder will affect the filling efficiency of the pharmaceutical powder, and the filling efficiency can reflect the filling performance of the pharmaceutical powder. Therefore, the critical filling speed determined according to the filling efficiency is used as a quantitative indicator for evaluating the filling performance of the pharmaceutical powder, which can improve the accuracy of the evaluation.

[0043] In some embodiments, calculating the filling efficiency corresponding to the filling speed according to the filling mass corresponding to the filling speed in step S20 includes: The quotient of the filling mass corresponding to the filling speed and the complete filling mass is determined as the filling efficiency, wherein the complete filling mass is the mass of the pharmaceutical powder when the storage device is fully filled.

[0044] The filling efficiency is calculated using the following formula: : ; Among them, m is the filling mass at a certain filling speed, M is the complete filling mass, and the complete filling mass can be measured using a pharmaceutical powder filling device. If the rotating component rotates one circle and the storage device is completely filled, the complete filling here means that the volume of the storage device is completely filled. At this time, the mass of the pharmaceutical powder in the storage device is the complete filling mass. The complete filling mass will vary depending on the density of the pharmaceutical powder.

[0045] Taking the sample pharmaceutical powder in the above embodiment as three different batches of fermented Cordyceps powder, the filling speeds are 10 mm / s, 100 mm / s, 150 mm / s, 200 mm / s, 250 mm / s, 300 mm / s, 350 mm / s, 400 mm / s and 500 mm / s as an example for explanation, the three different batches of fermented Cordyceps powder are respectively recorded as S1, S2, and S3, and the filling efficiency is calculated using the method in this embodiment. The results are shown in Table 2 below:

[0046] Table 2 Filling efficiency of pharmaceutical powders from different batches at different filling speeds According to Table 2, draw and fit the filling speed-filling efficiency curve. Figure 2 , Figure 3 as well as Figure 4 , Figure 2 This is a schematic diagram of the filling speed-filling efficiency curve of the sample pharmaceutical powder S1 in the embodiment of the present application, Figure 3 This is a schematic diagram of the filling speed-filling efficiency curve of the sample pharmaceutical powder S2 in the embodiment of the present application, Figure 4 Schematic diagram of the filling speed-filling efficiency curve of the sample pharmaceutical powder S3 in the embodiment of this application. represents the filling efficiency, It indicates the correlation between the predicted value and the actual observed value, and its value is between 0 and 1. The closer the value is to 1, the better the model fits the data. It can be seen that the filling speed-filling efficiency curves of the three batches of sample pharmaceutical powders are similar to power functions. , where V is the filling velocity, and a and b are power function parameters. Figure 2 , Figure 3 as well as Figure 4 The power function that the filling speed-filling efficiency curves of the three batches of sample pharmaceutical powders conform to can be calculated, and the function parameter fitting results are shown in Table 3 below:

[0047] Table 3 Parameters of the curve fitting function of filling speed-filling efficiency of pharmaceutical powders from different batches of samples In the above scheme, the filling efficiency is calculated based on the mass of the pharmaceutical powder loaded in the storage device, so that the evaluation of the filling performance is more accurate and objective. The calculation of the filling efficiency can help identify the changes in the efficiency of pharmaceutical powder filling at different filling speeds and provide guidance for the design of evaluation indicators.

[0048] In some embodiments, the critical filling speed is positively correlated with the filling performance of the pharmaceutical powder.

[0049] The greater the critical filling speed, the better the filling performance of the pharmaceutical powder, and vice versa. Because according to the determination method of the critical filling speed, at a filling speed greater than the critical filling speed, the mass of pharmaceutical powder that can be loaded by the storage device cannot meet the mass requirement of pharmaceutical powder that can be loaded at the critical filling speed, while at a filling speed less than the critical filling speed, the mass of pharmaceutical powder that can be loaded by the storage device can meet the mass requirement of pharmaceutical powder that can be loaded at the critical filling speed. Therefore, the greater the critical filling speed, the wider the range of selectable filling speeds and the better the filling performance.

[0050] In the above scheme, the filling performance of the pharmaceutical powder can be intuitively evaluated through the quantitative index of critical filling speed. The larger the value of the critical filling speed, the better the filling performance of the pharmaceutical powder, so that the critical filling speed can become a scientific quantitative standard for evaluating the filling performance of pharmaceutical powder.

[0051] In some embodiments, determining the critical filling speed according to the filling speed-filling efficiency curve in step S30 includes: The filling speed corresponding to the target filling efficiency on the filling speed-filling efficiency curve is determined as the critical filling speed.

[0052] The embodiment of the present application does not specifically limit the value of the target filling efficiency, and those skilled in the art may adjust it according to actual conditions, for example, setting the target filling efficiency to 50%, 70%, or 100%.

[0053] As an implementation method, the target filling efficiency can be determined as 100%. At this time, the critical filling speed is used as a quantitative indicator to evaluate the filling performance of the pharmaceutical powder. When the filling speed is less than the critical filling speed, the storage device will be completely filled with the pharmaceutical powder (η=1), and when the filling speed is greater than the critical filling speed, the storage device can only be partially filled (η<1). Taking Table 3 in the above embodiment as an example, when the filling efficiency is 100%, the functional expression of the pharmaceutical powder filling speed-filling efficiency curve fitting shows that the critical filling speeds of the sample pharmaceutical powders S1, S2, and S3 are 95.01 mm / s, 142.03 mm / s, and 89.74 mm / s, respectively, indicating that the filling performance of the three sample pharmaceutical powders S2>S1>S3.

[0054] In the above scheme, the critical filling speed is the critical value that meets the specific target filling efficiency requirements. Determining the critical filling speed can help select the most suitable filling speed while ensuring the filling efficiency, so that the quality of pharmaceutical powder filling in the production process is more stable and predictable.

[0055] Reference Figure 5 , Figure 5This is a structural schematic diagram of a pharmaceutical powder filling device provided in an embodiment of the present application, which is used to fill the target pharmaceutical powder into a storage device 101. The pharmaceutical powder filling device includes: a rotating component 102, a driving component 103, a fixing component 104 and a feeding component 105.

[0056] The rotating assembly 102 is connected to the driving assembly 103 , and the driving assembly 103 is used to drive the rotating assembly 102 to rotate around an axis.

[0057] The rotating component 102 is provided with a sample slot 106 for placing the storage device 101 . When the storage device 101 is placed in the sample slot 106 , the opening of the storage device 101 is not higher than the upper surface of the rotating component 102 .

[0058] The lower surface of the feeding component 105 is in contact with the upper surface of the rotating component 102 and a through hole is provided on the lower surface of the feeding component 105. The feeding component 105 is used to lay the target pharmaceutical powder. The through hole is used to fill the target pharmaceutical powder into the storage device when the sample slot 106 rotates to the bottom of the feeding component 105.

[0059] The fixing component 104 is used to fix the feeding component 105 so that the feeding component 105 does not rotate along with the rotating component 102 .

[0060] The rotating assembly 102 includes a platform body, which can be a round table, a square table, etc. The platform body is connected to the driving assembly 103 and rotates around the axis under the drive of the driving assembly 103. The rotation speed, that is, the filling speed, can be controlled by the driving assembly 103. A sample slot 106 is provided on the rotating assembly 102. The sample slot 106 is a concave structure, which is convenient for placing the storage device 101. The present application does not specifically limit the shape of the storage device 101. For example, it can be a sphere, a cone or a cuboid. Above the rotating assembly 102, there is a feeding assembly 105 that fits the platform body. The height of the part where the rotating assembly 102 fits the feeding assembly 105 is consistent. A through hole is provided on the side where the feeding assembly 105 fits the platform body, so that the target pharmaceutical powder laid in the feeding assembly 105 can naturally fall into the storage device 101 through the through hole.

[0061] As an embodiment, the filling speed may be a linear speed of the center of the sample slot 106 in the pharmaceutical powder filling device.

[0062] As an implementation method, refer to Figure 6-Figure 9 , Figure 6-Figure 9 A view showing a pharmaceutical powder filling device and a storage device, wherein: Figure 6 This is a front view of a pharmaceutical powder filling device provided in an embodiment of the present application. Figure 7 A top view of a pharmaceutical powder filling device provided in an embodiment of the present application, Figure 8 This is a front view of a storage device provided in an embodiment of the present application. Fig. 9 A front view of a feeding assembly of a pharmaceutical powder filling device provided in an embodiment of the present application. In this embodiment, the rotating assembly 102 includes a metal truncated cone with a radius of 246 mm, with four 1 mm circular holes in the center of the truncated cone, and a sample slot 106 with a specification of 25 mm × 25 mm on the edge of the truncated cone. The sample slot 106 has an inward concave structure, which is convenient for placing the storage device 101; above the truncated cone, there is a feeding assembly 105 that fits the truncated cone, and the feeding assembly 105 is trough-shaped; above the feeding assembly 105, a fixing assembly 104 is arranged, which is two adjustable fixing clamps; the driving assembly 103 is connected to the bottom of the truncated cone through the hole in the center of the truncated cone, including a stepping servo motor, a coupling between the stepping servo motor and the truncated cone, and the stepping servo motor is fixed on a square frame composed of an aluminum alloy bracket. The stepping servo motor is connected to a digital display control box, and a motor controller is arranged on the inner wall of the digital display control box, and a master control switch is arranged below the motor controller.

[0063] In some embodiments, a sealing strip is provided at a portion where the feeding component 105 is in contact with the rotating component 102, or a sealing strip is provided at a portion where the rotating component 102 is in contact with the feeding component 105 when the pharmaceutical powder filling device is working.

[0064] Optionally, the sealing strip can be a wool strip with glue, a rubber strip, a foam material or a brush strip.

[0065] In the above scheme, the sealing strip can improve the sealing between the feeding component 105 and the rotating component 102, making the fit between the feeding component 105 and the rotating component 102 tighter and more stable, and prevent the pharmaceutical powder from leaking from the gap during the filling process, thereby reducing material loss and environmental pollution.

[0066] The present application provides a pharmaceutical powder filling system, comprising: the pharmaceutical powder filling device in the above-mentioned device embodiment, a storage device 101 and an image acquisition device; the storage device 101 is placed in a sample slot 106, and the image acquisition device is used to capture the image corresponding to the storage device 101 when the pharmaceutical powder filling device is working.

[0067] The image acquisition device may include a high-speed camera located in front of the rotating assembly 102, and optionally, may also include a computer connected to the high-speed camera, and the computer may store and process images. The image acquisition device may also include a fill light.

[0068] In the above embodiment, the sample pharmaceutical powder is three different batches of fermented Cordyceps powder, and the filling speeds are 10 mm / s, 100 mm / s, 150 mm / s, 200 mm / s, 250 mm / s, 300 mm / s, 350 mm / s, 400 mm / s and 500 mm / s respectively. Fig.10 , Fig.10 A schematic diagram of the high-speed video recording of the filling quality of sample pharmaceutical powders S1, S2, and S3 at different filling speeds in the pharmaceutical powder filling system provided in the embodiment of the present application. It can be seen that sample pharmaceutical powders S1, S2, and S3 can be completely filled at a filling speed of 10 mm / s. At the same filling speed (the filling speed must be greater than the critical filling speed), sample pharmaceutical powder S2 fills the most pharmaceutical powder into the storage device 101, followed by sample pharmaceutical powder S1, and the sample pharmaceutical powder S3 fills the least pharmaceutical powder. It can be concluded that the filling performance of the three sample pharmaceutical powders S2>S1>S3. This conclusion is consistent with the conclusion drawn from the aforementioned method embodiment, which verifies the reliability of the method embodiment.

[0069] In the above scheme, the image acquisition device is used to capture images of the pharmaceutical powder filling status in the storage device when the pharmaceutical powder filling device is working, providing a basis for intuitively evaluating and analyzing the filling performance of the pharmaceutical powder, and also verifying the evaluation effect of the critical filling speed.

[0070] It should be understood that the pharmaceutical powder collection device corresponds to the above-mentioned pharmaceutical powder filling performance evaluation method embodiment, and can perform the various steps involved in the above-mentioned method embodiment. The specific functions of the device can be found in the above description. To avoid repetition, the detailed description is appropriately omitted here. The device includes at least one software function module that can be stored in a memory in the form of software or firmware or solidified in the operating system (OS) of the device.

[0071] The present application provides a computer program product, including computer program instructions, which, when read and executed by a processor, execute the methods provided by the above-mentioned method embodiments.

[0072] The present application provides a computer-readable storage medium, including: the computer-readable storage medium stores computer instructions, and the computer instructions enable the computer to execute the methods provided by the above-mentioned method embodiments.

[0073] Fig.11 A schematic diagram of the structure of an electronic device provided in an embodiment of the present application, such as Fig.11As shown, the electronic device includes: a processor 1101, a memory 1102 and a bus 1103; wherein the processor 1101 and the memory 1102 communicate with each other through the bus 1103; the memory 1102 stores program instructions that can be executed by the processor 1101, and the processor 1101 calls the program instructions to execute the methods provided by the above-mentioned method embodiments.

[0074] The processor 1101 includes one or more (only one is shown in the figure), which can be an integrated circuit chip with signal processing capabilities. The above-mentioned processor 1101 can be a general-purpose processor, including a central processing unit (CPU), a micro control unit (MCU), a network processor (NP) or other conventional processors; it can also be a dedicated processor, including a neural network processor (NPU), a graphics processor (GPU), a digital signal processor (DSP), an application specific integrated circuit (ASIC), a field programmable gate array (FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components. In addition, when there are multiple processors 1101, some of them can be general-purpose processors, and the other part can be dedicated processors.

[0075] The memory 1102 includes one or more (only one is shown in the figure), which may be, but not limited to, a random access memory (RAM), a read only memory (ROM), a programmable read-only memory (PROM), an erasable programmable read-only memory (EPROM), an electrically erasable programmable read-only memory (EEPROM), etc. The processor 1101 and other possible components may access the memory 1102 and read and / or write data therein.

[0076] In particular, one or more computer program instructions may be stored in the memory 1102 , and the processor 1101 may read and execute these computer program instructions to implement the weak password scanning behavior identification method provided in the embodiment of the present application.

[0077] The bus 1103 includes one or more (only one is shown in the figure), which can be used to communicate directly or indirectly with other devices to interact with data. The bus 1103 may include devices for wired and wireless communication, such as optical fiber, serial peripheral interface (Serial Peripheral Interface, referred to as SPI) module, integrated circuit bus (Inter-Integrated Circuit, referred to as I2C), etc., and may also include devices for wireless communication, such as Bluetooth module, Wi-Fi module, mobile communication module (such as 4G, 5G module), etc.

[0078] Understandably, Fig.11 The structure shown is for illustration only. The electronic device may also include Fig.11 More or fewer components as shown, or with Fig.11 Different structures are shown. Fig.11 The components shown in the figure can be implemented by hardware, software or a combination thereof. The electronic device may be a physical device, such as a switch, a router, a server, a PC, etc., or a virtual device, such as a virtual machine, a virtualized container, etc. Moreover, the electronic device is not limited to a single device, but may also be a combination of multiple devices or an integrated environment composed of a large number of devices.

[0079] In the embodiments provided in the present application, it should be understood that the disclosed devices and methods can be implemented in other ways. The device embodiments described above are merely schematic. For example, the division of the units is only a logical function division. There may be other division methods in actual implementation. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some communication interfaces, and the indirect coupling or communication connection of the devices or units can be electrical, mechanical or other forms.

[0080] In addition, the units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0081] Furthermore, the functional modules in the various embodiments of the present application may be integrated together to form an independent part, or each module may exist independently, or two or more modules may be integrated to form an independent part.

[0082] The above description is only an embodiment of the present application and is not intended to limit the protection scope of the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A method for evaluating the filling performance of pharmaceutical powders, characterized in that: include: Obtaining the filling masses of the pharmaceutical powder corresponding to different filling speeds, wherein the filling speed is the rotation speed of the rotating component in the pharmaceutical powder filling device, and the filling mass is the mass of the pharmaceutical powder received by the receiving device from the feeding component in the pharmaceutical powder filling device when the rotating component rotates one circle at the filling speed; For each filling speed, calculating the filling efficiency corresponding to the filling speed according to the filling mass corresponding to the filling speed; A filling speed-filling efficiency curve is determined according to multiple filling speeds and the filling efficiency corresponding to each filling speed, and a critical filling speed is determined according to the filling speed-filling efficiency curve, wherein the critical filling speed is used to evaluate the filling performance of the pharmaceutical powder filled by the pharmaceutical powder filling device.

2. The method according to claim 1, characterized in that The calculating the filling efficiency corresponding to the filling speed according to the filling mass corresponding to the filling speed includes: The quotient of the filling mass corresponding to the filling speed and the complete filling mass is determined as the filling efficiency, wherein the complete filling mass is the mass of the pharmaceutical powder when the storage device is fully filled.

3. The method according to claim 1, characterized in that The critical filling speed is positively correlated with the filling performance of the pharmaceutical powder.

4. The method according to any one of claims 1 to 3, characterized in that: Determining the critical filling speed according to the filling speed-filling efficiency curve includes: The filling speed corresponding to the target filling efficiency on the filling speed-filling efficiency curve is determined as the critical filling speed.

5. A pharmaceutical powder filling device, characterized in that: Used to implement the method described in any one of claims 1 to 4, used to fill the target pharmaceutical powder into a storage device, the pharmaceutical powder filling device comprising: a rotating component, a driving component, a fixing component and a feeding component; The rotating assembly is connected to the driving assembly, and the driving assembly is used to drive the rotating assembly to rotate around an axis; The rotating component is provided with a sample slot, the sample slot is used to place the receiving device, and the opening of the receiving device when placed in the sample slot is not higher than the upper surface of the rotating component; The lower surface of the feeding component is in contact with the upper surface of the rotating component and a through hole is provided on the lower surface of the feeding component. The feeding component is used to lay the target pharmaceutical powder, and the through hole is used to fill the target pharmaceutical powder into the storage device when the sample trough rotates to the bottom of the feeding component. The fixing component is used to fix the feeding component so that the feeding component does not rotate along with the rotating component.

6. The pharmaceutical powder filling device according to claim 5, characterized in that: A sealing strip is provided at a portion where the feeding component is in contact with the rotating component, or a sealing strip is provided at a portion where the rotating component is in contact with the feeding component when the pharmaceutical powder filling device is working.

7. A pharmaceutical powder filling system, characterized in that: include: The pharmaceutical powder filling device, storage device and image acquisition device as claimed in claim 5 or 6; The storage device is placed in the sample slot, and the image acquisition device is used to capture the image corresponding to the storage device when the pharmaceutical powder filling device is working.

8. A computer program product, characterized in that The method comprises computer program instructions, and when the computer program instructions are read and executed by a processor, the method according to any one of claims 1 to 4 is executed.

9. An electronic device, characterized in that: include: A processor, a memory and a bus, wherein the processor and the memory communicate with each other via the bus; The memory stores program instructions executable by the processor, and the processor can execute the method according to any one of claims 1 to 4 by calling the program instructions.

10. A computer-readable storage medium, characterized in that: include: The computer-readable storage medium stores computer instructions, and the computer instructions enable the computer to execute the method according to any one of claims 1 to 4.

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