Stem cell constant-temperature transportation and storage system

Abstract

The invention discloses a stem cell constant-temperature transportation and storage system which comprises a storage tank, the outer side of the storage tank is connected between U-shaped frames through a rear shaft, the U-shaped frames are fixedly connected to the upper end of a supporting seat, one side of the upper end of each U-shaped frame is connected with a first worm gear through a shaft, and the upper end, located on one side of the first worm gear, of each U-shaped frame is connected with a first worm through a bearing; and the first worm wheel is fixedly connected to the outer side of the storage tank through a shaft, a movable plate is longitudinally and slidably connected to the position, located on the inner side of the lower portion of the U-shaped frame, of the supporting base, and a lifting adjusting mechanism is arranged between the U-shaped frame and the movable plate. The overturning position of the storage tank can be fixed, operation is convenient, liquid nitrogen can be conveniently poured or injected, the movable plate can be driven to ascend and descend in a threaded mode by rotating the second rotating disc, and when the movable plate descends, the universal wheels at the bottom of the movable plate make contact with the ground, and the supporting base can be erected.

Description

Technical Field

[0001] The present invention relates to the technical field of stem cell storage, and in particular to a constant temperature transportation and storage system for stem cells. Background Art

[0002] Stem cells, also known as "seed cells", are a type of cell with unlimited or immortal self-renewal ability, which can produce at least one type of highly differentiated daughter cells. Stem cells have the characteristics of self-renewal, unlimited proliferation and multidirectional differentiation potential. According to their developmental potential, stem cells can be divided into three categories: totipotent stem cells, pluripotent stem cells, and unipotent stem cells; according to their developmental stage, they can be divided into two categories: embryonic stem cells and adult stem cells. In theory, stem cells can be used for clinical cell transplantation to treat various diseases and construct artificial tissues or organs. Suitable diseases include: tissue necrosis diseases such as myocardial necrosis caused by ischemia, degenerative lesions such as Parkinson's syndrome, autoimmune diseases such as rheumatoid arthritis, diabetes, and bone and joint diseases. However, most of the research is still in the clinical trial stage, and only hematopoietic stem cell transplantation has become a routine operation to treat blood system diseases.

[0003] At present, stem cells need to be refrigerated during the process of movement and storage. During refrigeration, the stem cells need to be initially cooled down and then placed in storage boxes. The placed storage boxes are then placed in liquid nitrogen tanks. However, the liquid nitrogen tanks on the market vary in size and are heavy, so it is cumbersome to move and dump the liquid nitrogen in the liquid nitrogen tanks. Therefore, a constant temperature transportation and storage system for stem cells is provided to solve the above problems. Summary of the invention

[0004] In order to solve the problems in the above background technology, the technical solution adopted by the present invention to solve the technical problems is: a constant temperature transportation and storage system for stem cells, which includes: a storage tank, the outer side of the storage tank is connected between the U-shaped frames through a rear axle, the U-shaped frame is fixedly connected to the upper end of the support seat, one side of the upper end of the U-shaped frame is connected to a first worm gear through an axis, the upper end of the U-shaped frame is located on one side of the first worm gear and is connected to a first worm through bearings up and down, the first worm gear is fixedly connected to the outer side of the storage tank through a shaft, the support seat is located below the U-shaped frame and is longitudinally slidably connected to a movable plate on the inner side, and a lifting and lowering adjustment mechanism is provided between the U-shaped frame and the movable plate.

[0005] As a preferred technical solution of the present invention, the lifting and adjusting mechanism includes a second worm, a threaded column, and a second worm wheel. The two ends of the second worm are connected to the inside of the U-shaped frame through bearings, the threaded column is connected to the middle of the U-shaped frame through bearings, and the second worm wheel is fixedly connected to the top of the threaded column.

[0006] As a preferred technical solution of the present invention, a universal wheel is provided at the bottom of the movable plate, the first worm is meshed and connected to the first worm wheel, the top of the first worm is connected to the first turntable, and a protective cover is provided at the upper end of the U-shaped frame on one side of the first worm wheel.

[0007] As a preferred technical solution of the present invention, one end of the second worm passes through the U-shaped frame and is fixedly connected to the second turntable, and the second worm gear is meshedly connected to the threaded column, and the threaded column thread passes through the middle of the movable plate.

[0008] As a preferred technical solution of the present invention, a storage liner is arranged inside the storage tank, and a vacuum chamber is arranged between the storage liner and the storage tank.

[0009] As a preferred technical solution of the present invention, a pick-up and release opening is arranged at the top of the storage tank, a suspension rod clamping slot is opened at the top of the pick-up and release opening, and a suspension rod body is clamped inside the suspension rod clamping slot.

[0010] As a preferred technical solution of the present invention, the bottom of the suspension rod body extends to the interior of the storage liner and is connected to a cell storage box. The suspension rod slots are provided in a plurality and are evenly distributed on the top of the pick-up and release opening.

[0011] As a preferred technical solution of the present invention, a sealing cover is sleeved inside the pick-up and release port, and a limiting groove is provided on the outer side of the circumference of one end of the sealing cover inside the pick-up and release port, and the limiting groove faces the boom body.

[0012] As a preferred technical solution of the present invention, a vacuum port is provided on one side of the upper end of the storage tank, and the vacuum port is connected to the inside of the vacuum chamber.

[0013] As a preferred technical solution of the present invention, the interior of the support seat is a hollow structure, support legs are provided at the bottom corners of the support seat, and anti-slip pads are provided at the bottom of the support legs.

[0014] The present invention has the following advantages: the storage tank can be turned over by rotating the first rotating disk, and the turned position of the storage tank can be fixed when the first rotating disk stops rotating, which is convenient for operation and convenient for pouring or injecting liquid nitrogen;

[0015] By rotating the second turntable, the thread can drive the movable plate to rise and fall. When the movable plate is lowered, the universal wheel at the bottom of the movable plate contacts the ground and the support seat can be erected, so that it is convenient for personnel to move the storage tank for transportation;

[0016] The vacuum chamber between the storage tank and the storage liner ensures that the temperature of the liquid nitrogen in the storage liner will not be affected by the external temperature, thereby keeping the temperature of the stored cells constant. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of a preferred embodiment of the present invention;

[0018] Figure 2 It is a schematic diagram of a partially split cross-sectional structure of a preferred embodiment of the present invention;

[0019] Figure 3 is a schematic diagram of the connection structure between the U-shaped frame and the first worm gear in a preferred embodiment of the present invention;

[0020] Figure 4 It is a preferred embodiment of the present invention Figure 2 A magnified schematic diagram of structure A;

[0021] Figure 5 is a schematic cross-sectional structural diagram of a support base in a preferred embodiment of the present invention;

[0022] Figure 6 It is a schematic diagram of the connection structure between the U-shaped frame and the threaded column according to a preferred embodiment of the present invention.

[0023] Explanation of the accompanying drawings: 1. storage tank; 2. support seat; 3. U-shaped frame; 4. first worm wheel; 5. first worm; 6. first turntable; 7. protective cover; 8. movable plate; 9. universal wheel; 10. second worm; 11. threaded column; 12. second worm wheel; 13. second turntable; 14. storage liner; 15. vacuum chamber; 16. take-and-place port; 17. suspension rod slot; 18. suspension rod body; 19. cell storage box; 20. support leg; 21. sealing cover; 22. limit groove; 23. vacuum port. DETAILED DESCRIPTION

[0024] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. In the description of the present invention, it should be noted that the terms "center", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicate directions or positional relationships based on the directions or positional relationships shown in the accompanying drawings, which are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0025] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0026] In order to more clearly understand the above-mentioned objects, features and advantages of the present invention, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0027] Please refer to Figure 1-Figure 6 The present invention provides a constant temperature transportation and storage system for stem cells, comprising: a storage tank 1, the outer side of the storage tank 1 is connected between a U-shaped frame 3 through a rear axle, the U-shaped frame 3 is fixedly connected to the upper end of a support seat 2, one side of the upper end of the U-shaped frame 3 is connected to a first worm gear 4 through an axis, the upper end of the U-shaped frame 3 is located on one side of the first worm gear 4 and is connected to a first worm 5 through bearings up and down, the first worm gear 4 is fixedly connected to the outer side of the storage tank 1 through an axis, the support seat 2 is located below the U-shaped frame 3 and is longitudinally slidably connected to an movable plate 8 on the inner side, and a lifting and lowering adjustment mechanism is provided between the U-shaped frame 3 and the movable plate 8.

[0028] Combination Figure 3 and Figure 4 As shown, the lifting and lowering adjustment mechanism includes a second worm 10, a threaded column 11, and a second worm wheel 12. Both ends of the second worm 10 are connected to the inside of the U-shaped frame 3 through bearings, and the threaded column 11 is connected to the middle of the U-shaped frame 3 through bearings, so that the second worm 10 is meshed to drive the second worm wheel 12 to rotate, and the second worm wheel 12 is fixedly connected to the top of the threaded column 11. A universal wheel 9 is arranged at the bottom of the movable plate 8. The universal wheel 9 cooperates with the supporting leg 20 to facilitate switching one of the contacting ground according to needs, so as to facilitate moving or placing the storage tank 1. The first worm 5 is meshed and connected to the first worm wheel 4. The top of the first worm 5 is connected to the first turntable 6. The upper end of the U-shaped frame 3 is located on one side of the first worm wheel 4 and is provided with a protective cover 7. One end of the second worm 10 penetrates the U-shaped frame 3 and is fixedly connected to the second turntable 13. The second worm wheel 12 is meshed and connected to the threaded column 11. The thread of the threaded column 11 penetrates the middle of the movable plate 8.

[0029] Combination Figure 2 and Figure 4As shown, a storage liner 14 is provided inside the storage tank 1, and a vacuum chamber 15 is provided between the storage liner 14 and the storage tank 1. The vacuum chamber 15 can improve the insulation effect of the liquid nitrogen temperature inside the storage liner 14, so that the internal temperature of the storage liner 14 is always kept constant. A pick-up and release port 16 is provided at the top of the storage tank 1, and a suspension rod slot 17 is provided at the top of the pick-up and release port 16. A suspension rod body 18 is clamped inside the suspension rod slot 17, so as to facilitate the placement of the suspension rod body 18. The bottom of the suspension rod body 18 extends to the inside of the storage liner 14 and is connected to a cell storage box 19. There are a plurality of suspension rod slots 17, and the plurality of suspension rod slots 17 are evenly distributed on the top of the pick-up and release port 16. A sealing cover 21 is sleeved inside the taking and releasing port 16, and a limiting groove 22 is provided on the outer side of the circumference of one end of the sealing cover 21 inside the taking and releasing port 16. The limiting groove 22 is opposite to the boom body 18, so that the boom body 18 can be limited by the sealing cover 21 to ensure that the boom body 18 will not shift. A vacuum port 23 is provided on one side of the upper end of the storage tank 1, and the vacuum port 23 is connected to the inside of the vacuum chamber 15. The interior of the support seat 2 is a hollow structure, and a support leg 20 is provided at the bottom corner of the support seat 2, and an anti-slip pad is provided at the bottom of the support leg 20.

[0030] Specifically, when the present invention is used, the first turntable 6 can be rotated to cause the first worm 5 to rotate, and then the first worm 5 engages to drive the first worm wheel 4 to rotate, and then the first worm wheel 4 rotates the shaft connected to the storage tank 1, and then the storage tank 1 can be flipped, and when the first turntable 6 stops rotating, the flipped position of the storage tank 1 can be fixed, so as to facilitate pouring or injecting liquid nitrogen, when the second turntable 13 is rotated, the second worm 10 can be rotated, and then the second worm 10 engages to drive the second worm wheel 12 to rotate, and then the second worm wheel 12 rotates the threaded column 11, and then the threaded column 11 can threadably drive the movable plate 8 to rise and fall, and when the movable plate 8 descends, the universal wheel 9 at the bottom of the movable plate 8 contacts the ground and the support seat 2 can be erected, so as to facilitate personnel to move the storage tank 1 for transportation.

[0031] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the attached claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention. Any figure mark in the claims should not be regarded as limiting the claims involved.

[0032] Other parts of the present invention not described in detail belong to the prior art and will not be described in detail here.

[0033] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A constant temperature transportation and storage system for stem cells, comprising: A storage tank (1), characterized in that the outer side of the storage tank (1) is connected to a U-shaped frame (3) through a rear shaft, the U-shaped frame (3) is fixedly connected to the upper end of a support seat (2), one side of the upper end of the U-shaped frame (3) is connected to a first worm gear (4) through an axis, the upper end of the U-shaped frame (3) is located on one side of the first worm gear (4) and is connected to a first worm (5) through bearings, the first worm gear (4) is fixedly connected to the outer side of the storage tank (1) through an axis, the support seat (2) is located below the U-shaped frame (3) and is longitudinally slidably connected to a movable plate (8), and a lifting and lowering adjustment mechanism is provided between the U-shaped frame (3) and the movable plate (8).

2. A constant temperature transportation and storage system for stem cells as claimed in claim 1, characterized in that: The lifting and lowering adjustment mechanism comprises a second worm (10), a threaded column (11), and a second worm wheel (12); both ends of the second worm (10) are connected to the inside of the U-shaped frame (3) via bearings; the threaded column (11) is connected to the middle of the U-shaped frame (3) via a bearing; and the second worm wheel (12) is fixedly connected to the top of the threaded column (11).

3. A constant temperature transportation and storage system for stem cells as claimed in claim 1, characterized in that: A universal wheel (9) is arranged at the bottom of the movable plate (8); the first worm (5) is meshedly connected to the first worm wheel (4); the top end of the first worm (5) is connected to the first turntable (6); and a protective cover (7) is arranged at the upper end of the U-shaped frame (3) on one side of the first worm wheel (4).

4. A constant temperature transportation and storage system for stem cells as claimed in claim 2, characterized in that: One end of the second worm (10) passes through the U-shaped frame (3) and is fixedly connected to a second rotating disk (13); the second worm wheel (12) is meshedly connected to a threaded column (11); and the threaded column (11) threadably passes through the middle of the movable plate (8).

5. The constant temperature transportation and storage system for stem cells according to claim 1, characterized in that: A storage liner (14) is arranged inside the storage tank (1), and a vacuum chamber (15) is arranged between the storage liner (14) and the storage tank (1).

6. The constant temperature transportation and storage system for stem cells according to claim 1, characterized in that: The top of the storage tank (1) is provided with a pick-up and release opening (16), the top of the pick-up and release opening (16) is provided with a suspension rod clamping groove (17), and a suspension rod body (18) is clamped inside the suspension rod clamping groove (17).

7. A constant temperature transportation and storage system for stem cells as claimed in claim 6, characterized in that: The bottom of the suspension rod body (18) extends to the interior of the storage liner (14) and is connected to a cell storage box (19). The suspension rod slots (17) are provided in a plurality, and the plurality of suspension rod slots (17) are evenly distributed at the top of the pick-up and release opening (16).

8. A constant temperature transportation and storage system for stem cells as claimed in claim 6, characterized in that: A sealing cover (21) is sleeved inside the taking and releasing opening (16), and a limiting groove (22) is provided on the outer side of the circumference of one end of the sealing cover (21) inside the taking and releasing opening (16), and the limiting groove (22) is directly opposite to the suspension rod body (18).

9. The constant temperature transportation and storage system for stem cells according to claim 1, characterized in that: A vacuum port (23) is provided on one side of the upper end of the storage tank (1), and the vacuum port (23) is communicated with the interior of the vacuum chamber (15).

10. The constant temperature transportation and storage system for stem cells according to claim 1, characterized in that: The interior of the support seat (2) is a hollow structure, a support leg (20) is provided at a bottom corner of the support seat (2), and an anti-slip pad is provided at the bottom of the support leg (20).

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