Parameter differential separation process

Abstract

The invention discloses a parameter differential separation process, and relates to the technical field of separation. The defects in the prior art are overcome. The method specifically comprises the following steps: carrying out a generalized separation process by using a parameter differential moving bed, and operating the generalized separation process to eliminate a displacement zone in chromatographic sequential operation; the method comprises the following steps: contacting a mobile-phase liquid feeding solution with solid-phase resin / adsorbent filler through a novel mass transfer equilibrium contact method, and starting to obtain a characteristic separation curve; the multiple components contained in the mobile phase liquid feed solution are separated by a new mass transfer equilibrium contact process such that at least one component contained in the mobile phase liquid feed solution can be adsorbed onto the resin / adsorbent. The method realizes final separation of a large-scale production separation system, improves the maximum mass transfer efficiency, can also be used for a binary separation system in the separation process of glucose and fructose, reduces the consumption of washing liquid, and reduces the final power consumption.

Description

Technical Field

[0001] The invention relates to the field of separation technology, and in particular to a parameter differential separation process. Background Art

[0002] Today, many stationary solid phase and mobile phase combinations can be used when separating mixtures. There are several different types of laboratory analytical or pilot-scale chromatography, which are classified according to the physical state of these phases. Among them, liquid-solid column chromatography is a liquid mobile phase that slowly filters the solid stationary phase, carrying away the separated components. It relies on a pump device to pass a pressurized liquid containing a mixture of components through a chromatographic column filled with solid adsorbent material. Each component in the sample interacts slightly differently with the adsorbent material, resulting in different transport rates for different components, which causes the components to separate when they flow out of the chromatographic column; commercial chromatography used in large-scale production devices has chemical adsorption and desorption interactions related to the mass transfer equilibrium phenomenon between the component mixture and the solid in the liquid phase; fixed-bed intermittent batch chromatography columns are the main devices with the most widespread separation applications. Liquid chromatography has the advantages of faster and easier analysis compared to gas chromatography. For example, a simulated moving bed process as described in U.S. Pat. No. 3,761,533 and U.S. Pat. No. 3,201,491 is used, and an arrangement with multiple chromatography columns as taught in U.S. Pat. No. 4,522,726 and U.S. Pat. No. 4,808,317 is used to perform a continuous solid and liquid contacting device.

[0003] All of the above mentioned mass production processes contain certain differences, but they all belong to the same category, that is, fixed materials are packed inside the column and the configuration of the column is modified to some extent to improve the efficiency of fluid distribution and thus increase production rate. However, there are also the following defects, such as: a) the resin / adsorbent is used inefficiently, and the mass transfer is only carried out gradually at the front of the mass transfer zone, resulting in the solid phase before and after the zone being idle; b) due to the presence of a displacement zone in the chromatographic process, excessive dilution and increased cycle time are caused, which aggravates the inefficient use of the adsorbent; c) engineering defects in the chromatographic column process that destroy the characteristic elution curve of the components are listed as follows: ① Flow dynamics: axial dispersion and diffusion effects are important in affecting the separation quality, including back mixing at the end effect of the chromatographic column; ② Column geometry: during the inlet and precipitation process of the chromatographic column, the end effect of the chromatographic column includes the dead volume required to provide additional fluid volume to fill the liquid pipeline from the liquid introduction point and the existence point of the chromatographic column system; ③ Load limitation: in order to avoid peak broadening, overlap and tailing due to flow dynamics, this will be forced to produce additional dilution of the separated fractions due to engineering defects; d) The separation period is long, further weakening the economic consumption of adsorbents and eluents, aggravating the above engineering defects; e) High pressure drop and difficult maintenance, etc.

[0004] Therefore, productivity needs to be compromised with purity and separation efficiency, and complex schemes are usually required, resulting in expensive support systems, especially in large-scale industrial separation processes. To this end, the present invention provides a parameter differential separation process suitable for large-scale industrial separation processes. Summary of the invention

[0005] The purpose of the present invention is to solve the shortcomings of the prior art and to propose a parameter differential separation process.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] A parameter differential separation process comprises the following steps:

[0008] S1: Use parametric differential moving bed as generalized separation process, operate generalized separation process to eliminate displacement zone in chromatographic sequential operation;

[0009] S2: The mobile phase liquid feed solution is contacted with the solid phase resin / adsorbent filler by a new mass transfer equilibrium contact method to begin to obtain a characteristic separation curve;

[0010] S3: separating the multiple components contained in the mobile phase liquid feed solution by a new mass transfer equilibrium contact method, so that at least one component contained in the mobile phase liquid feed solution can be adsorbed onto the resin / adsorbent;

[0011] S4: transporting various liquid solutions of at least a second and a third mobile phase by a new mass transfer equilibrium contact method;

[0012] The generalized separation process is to convert the flow direction of the mobile phase of the chromatographic mass transfer mechanism from a parallel path to a perpendicular path with the placed solid phase, specifically: using the generalized separation process to simultaneously introduce each integral unit containing a specific resin / adsorbent filler into the corresponding mobile phase to eliminate the displacement zone in the chromatographic sequential operation, and the specific operation content of eliminating the displacement zone is: introducing various liquid solutions in the sequential operation, first by optimizing the same predetermined mobile phase parameters and resin / adsorbent filler as a predetermined combination to generate an acceptable elution curve of the target separation system to be performed in a typical chromatographic separation;

[0013] The S2 step includes determining the flux of the mobile phase liquid feed solution and the solid phase amount of the resin / adsorbent for the optimal full-strength adsorption capacity;

[0014] The content of the step S3 is specifically as follows: dissolving at least one circulating liquid stream having a specific solute composition in a predetermined eluent solution mixture with modified characteristic parameters by a new mass transfer equilibrium contact method to elute a specific adsorbed solute component; all circulating liquid streams are arranged in sequence and contacted with resin / adsorbent to separate at least one desired component migrating through various circulating streams;

[0015] The liquid solution comprises a predetermined composition that is contacted with a solid phase resin / adsorbent filler;

[0016] The resin / adsorbent is a granular material, and the granular material is one of a granular ion exchange resin / adsorbent, a granular ligand exchange resin / adsorbent, a granular reverse phase resin / adsorbent, a granular affinity resin / adsorbent, a granular normal phase resin / adsorbent, a granular activated carbon and a granular catalyst;

[0017] The parametric differential moving bed is operated by a differential setting procedure and a single-stage recovery procedure, which is a general procedure of a new mass transfer equilibrium contact method between a solid and a mobile phase, including the following mixed examples:

[0018] A1-New mass transfer equilibrium contact method;

[0019] A2-New mass transfer equilibrium contact method obtains the characteristic separation curve of a specific separation system by keeping the resin / adsorbent solid phase in a semi-dry state as the optimal full-strength adsorption capacity in contact with the mobile phase liquid feed solution volume;

[0020] The A3-parameter differential moving bed includes an upstream storage tank module, an upstream rotary connection module, a separation module, a downstream rotary connection module, a downstream storage tank module and an inert gas supply module, wherein the upstream rotary connection module serves as a bridge between the upstream storage tank module and the separation module, the downstream rotary connection module serves as a bridge between the bottom of the separation module and the downstream storage tank module, and the inert gas supply module is a transmission mechanism submodule for the mobile phase liquid flow and integrated with the separation module; the upstream storage tank module, the upstream rotary connection module, the separation module, the downstream rotary connection module, the downstream storage tank module and the inert gas supply module are operated in parallel;

[0021] A4-Generalized separation process by the differential setting program scheme adopted by the general procedure of the new mass transfer equilibrium contact method: adopting a predetermined matching mobile phase input mode selected between SI mode and II mode to obtain a characteristic separation curve of a specific separation system associated with the selected resin / adsorbent solid phase and combining various mobile phase liquid solutions into a parameter differential moving bed for separating at least one desired component from the liquid solution mixture continuously and simultaneously within each minimum time interval spent;

[0022] A5-The general separation process adopts a single-stage recovery program scheme on a parameter differential moving bed through a new mass transfer equilibrium contact method: through a mobile phase liquid flow transmission mechanism together with each module arranged in a parameter differential moving bed, to simultaneously and intermittently transport each mobile phase liquid flow originally stored in a corresponding upper storage tank arranged in an upstream storage tank module to the separation module for the expected new mass transfer equilibrium contact method.

[0023] Preferably: the monolithic unit is used to separate a specific solute mixture containing at least one desired component from at least one other component into a limited composition, a homogeneous liquid solution mixture containing the solute mixture as a feed solution mobile phase, interacting with a resin / adsorbent particulate material and multiple dissolved components in a mobile phase stream to promote adsorption, a novel mass transfer equilibrium contact method between the two phases;

[0024] The feed solution mobile phase is a solute component of a mixture of oligosaccharides, glucose and fructose, which is used to continuously and simultaneously separate at least one desired component from a liquid solution mixture containing one component and at least another component, and includes a component percentage composition and dry solids uniformly dissolved in deionized, foul-free water; the solute component has a limited component percentage composition and a limited dry solids concentration dissolved in a limited volume of deionized, foul-free eluent water to promote the adsorption of at least one component onto the resin / adsorbent, and each circulating flow contains a solute composition dissolved in a predetermined limited solute percentage composition, and the eluent solution mixture The compound and the eluent are the same deionized water-free water, and the feed solution mobile phase is rapidly passed through at least one integral unit simultaneously and intermittently to achieve the expected new mass transfer equilibrium contact method, separating at least one component from at least one other component to obtain a concentrated dry solid concentration and gradually separated glucose and fructose components, wherein the resin / adsorbent is orderly arranged in at least one integral unit of the device, and the resin / adsorbent is an alkaline earth metal base strong acid cation exchanger in particles, and the alkaline earth metal base strong acid cation exchanger is a calcium base strong acid cation exchanger.

[0025] Preferably: the resin / adsorbent fillers include ion exchange, affinity, reverse phase, normal phase, ligand exchange, granular activated carbon and catalyst.

[0026] Preferably, the resin / adsorbent interacts with multiple dissolved components in the mobile phase flow to promote new mass transfer equilibrium contact, including the following:

[0027] S31: In the first mobile phase zone of the upstream storage tank module, at least one of the first mobile phase flows contained in the upper storage tank is a new mass transfer equilibrium contact method that promotes adsorption, that is, the feed solution and the dissolved components are arranged in the first mobile phase zone, i.e., the feed zone; and at least one corresponding lower storage tank arranged in the downstream storage tank module is used to receive and contain the liquid discharged from the first mobile phase and transport it to the last mobile phase zone, i.e., the washing zone;

[0028] S32: in the second mobile phase zone of the upstream storage tank module, at least one of the second mobile phase flows contained therein is an adsorbed component eluted with at least one of the second mobile solutions in at least one impurity stripping zone; and at least one corresponding lower storage tank disposed in the downstream storage tank module is used to receive and contain the liquid discharged from the corresponding second mobile phase;

[0029] S33: In the third mobile phase zone of the upstream tank module, at least one of the third mobile phase flows contained therein is eluted with at least one adsorbed component in at least one third mobile solution of the product recovery zone; and at least one corresponding lower tank is arranged in the downstream tank module to receive and hold the liquid discharged by the corresponding third mobile phase, and at least one recovered product after elution is to increase the corresponding concentration level of the eluted product and return to the designated upper tank 15 of the at least one product recovery zone as a recovery flow;

[0030] S34: in the fourth and fifth mobile phase zones of the upstream storage tank module, at least one of the fourth and fifth mobile phase flows contained therein is used to further elute at least one adsorbed component in sequence with at least one regeneration zone and additional zone of at least one fourth and fifth mobile phase solutions; and at least one corresponding lower storage tank provided in the downstream storage tank module is provided to receive and hold liquid discharged from the fourth and fifth mobile phases corresponding to at least one component eluted, so as to increase the concentration level of each recovered component, and return it to the designated upper storage tank as a circulating flow, corresponding to at least one regeneration zone and additional zone;

[0031] S35: In the washing zone of the upstream tank module, at least one first mobile phase flow contained in each upper tank is transported to clean and wash off the installed resin / adsorbent solid filler; and at least one corresponding lower tank arranged in the downstream tank module is used to receive and contain the liquid discharged by the first mobile phase, adjust and mix it with the components in the feed solution, and return it to the designated upper tank of the feed zone as a recovery flow.

[0032] Preferably: the new mass transfer equilibrium contact method in A1 comprises the following steps:

[0033] i) retaining a predetermined amount of solid phase resin / adsorbent uniformly distributed in a predetermined number of chromatographic single columns, so that the bundled column group acts as an integral unit;

[0034] ii) intermittently delivering a predetermined amount of mobile phase liquid material to the integrated unit via a predetermined type of liquid distributor to contact the resin / adsorbent during a predetermined first time period;

[0035] iii) during a predetermined second time period, after each delivery of the mobile phase liquid material, intermittently supplying a wide range of pressurized inert gas to the top of the integral unit;

[0036] Wherein, step iii) further comprises providing a vacuum environment from the bottom of the integral unit to the other side of the installed solid phase material;

[0037] wherein step iii) further comprises collecting a majority of the processed mobile phase liquid material from the outlet at the bottom of the integral unit, and repeating steps ii) to iii) until a predetermined sequence of the plurality of liquid solutions is satisfied;

[0038] Wherein, the total time taken for steps ii) to iii) is the minimum time interval Δt;

[0039] An equal amount of resin / adsorbent material is retained in each individual column in the monolithic unit;

[0040] The mobile phase liquid material includes a predetermined composition of various liquid solutions of predetermined composition in at least the second and third mobile phases including the mobile phase liquid feed solution, and at least one circulating liquid flow is organized in sequence.

[0041] Preferably: A2, a method for separating a plurality of components contained in at least one first mobile phase flow in a liquid solution containing the components by sequentially contacting the solid phase resin / adsorbent with at least one mobile phase liquid feed solution, wherein a predetermined amount of resin / adsorbent solid phase is arranged in the integral unit, so that at least one of the components is adsorbed by the resin / adsorbent;

[0042] The first mobile phase flows and is consumed in the minimum time interval for the feed zone.

[0043] Preferably: the liquid input format delivered by the liquid dispenser includes SI mode and II mode, wherein the duration of the input SI mode along the time domain is that during each time period of the minimum time interval, a predetermined amount of solution with the same mobile phase parameter condition is delivered into the integral unit through a predetermined type of liquid dispenser; in addition, the input II mode is that discrete increments of a predetermined amount of mobile phase parameter condition liquid are delivered in the time domain in a sequence of duration within the minimum time interval, and enter the integral unit through a predetermined type of liquid dispenser; various characteristic parameters are selected as mobile phase conditions of the homogeneous liquid solution, including pH value, ionic strength, solubility, polarity named after a wide spectrum of changes, and combined with the selected resin / adsorbent filler, it is a combined selection of intermittent operation modes, that is, various liquid solutions are introduced in sequential operation;

[0044] The option of entering SI mode obtains a characteristic separation curve by delivering the mobile phase as follows:

[0045] A201: intermittently delivering a predetermined amount of at least one of a plurality of first mobile phase flows to an inlet of the integral unit within a predetermined first time period;

[0046] A202: During a predetermined second time period, after each delivery of the first mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit so as to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit, and at the same time, a vacuum environment is maintained on the other side of the integral unit where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state;

[0047] A203: Collects most of the processed mobile phase liquid material from the outlet at the bottom of the monolithic unit;

[0048] A204: Define the total time spent in steps A201-A203 as the minimum time interval;

[0049] A205: repeating step A204 until all at least one first mobile phase flow is sequentially delivered and the total cumulative minimum time interval is the first mobile phase zone, and then after a predetermined amount of the first mobile phase flow is intermittently delivered, the resin / adsorbent is further sequentially contacted with at least one second mobile phase flow to achieve a desired new mass transfer equilibrium contact method, so that at least one component is sequentially desorbed separately from the resin / adsorbent;

[0050] A206: intermittently delivering a plurality of at least one predetermined amount of the second mobile phase flow to an inlet of the integral unit during a predetermined first time period;

[0051] A207: During a predetermined second time period, after each delivery of the second mobile phase, intermittently supplying pressurized inert gas to the top of the integral unit to rapidly push the delivered second mobile phase through the resin / adsorbent installed in the integral unit, and at the same time, maintaining a vacuum environment on the other side of the integral unit where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state;

[0052] A208: Collects most of the processed mobile phase liquid material from the outlet at the bottom of the monolithic unit;

[0053] A209: Define the total time spent in steps A206-A208 as the minimum time interval;

[0054] A210: repeating step A209 until all at least one second mobile phase flow is sequentially delivered and the total cumulative minimum time interval is the second mobile phase zone, and then after a predetermined amount of the second mobile phase flow is intermittently delivered, the resin / adsorbent is further sequentially contacted with at least one third mobile phase flow to achieve a desired new mass transfer equilibrium contact method, so that at least one component is sequentially desorbed separately from the resin / adsorbent;

[0055] A211: intermittently delivering a plurality of predetermined amounts of at least one of the third mobile phase streams to an inlet of the integral unit during a predetermined first time period;

[0056] A212: During a predetermined second time period, after each delivery of the third mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit so as to rapidly push the delivered third mobile phase through the resin / adsorbent installed in the integral unit, and at the same time, a vacuum environment is maintained on the other side of the integral unit where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state;

[0057] A213: Collects most of the processed mobile phase liquid material from the outlet at the bottom of the monolithic unit;

[0058] A214: Define the total time spent in steps A211-A213 as the minimum time interval;

[0059] A215: repeating step A214 until all at least one third mobile phase flow is delivered in sequence and the total cumulative minimum time interval is the third mobile phase zone, if the remaining components are still adsorbed by the resin / adsorbent, repeating step A215 by adding at least one fourth mobile phase flow so that the components can be eluted by a predetermined composition to achieve the expected new mass transfer equilibrium contact method, so that the remaining components are sequentially desorbed from the resin / adsorbent separately, if the remaining components are not adsorbed by the resin / adsorbent, proceeding to step A216;

[0060] A216: intermittently delivering at least one predetermined amount of the discharged and collected first mobile phase streams to the inlet of the integrated unit in step A203 within a predetermined first time period;

[0061] A217: During a predetermined second time period, after each delivery of the first mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit, and at the same time, a vacuum environment is maintained on the other side of the integral unit where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state;

[0062] A218: Collects most of the processed mobile phase liquid material from the outlet at the bottom of the monolithic unit;

[0063] A219: Define the total time spent in steps A216-A218 as the minimum time interval;

[0064] A220: repeating step A219 until at least one of all first mobile phase streams is delivered in sequence and the total cumulative minimum time interval is the last mobile phase zone;

[0065] A221: Finally, all defined regions are integrated in turn according to the mobile phase parameter conditions in the time domain, thereby obtaining the characteristic separation curve of a specific separation system by inputting the SI mode.

[0066] Preferably, the option of the input II mode obtains a characteristic separation curve by delivering the mobile phase through the following procedure:

[0067] A251: intermittently delivering a predetermined amount of at least one of the first mobile phase flows to an inlet of the integral unit during a predetermined first time period;

[0068] A252: During a predetermined second time period, after each delivery of the first mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit, and at the same time, a vacuum environment is maintained on the other side of the integral unit where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state;

[0069] A253: Collects most of the processed mobile phase liquid material from the outlet at the bottom of the monolithic unit;

[0070] A254: The total time spent in steps A251-A253 is defined as the minimum time interval, also known as the first discrete mobile phase region;

[0071] A255: repeating step A254, by increasing the discrete increments of the mobile phase parameter conditions until all adjusted at least one first mobile phase flow is sequentially delivered with a preset incremental discrete and total cumulative minimum time interval being a plurality of first discrete mobile phase zones, which are sequentially named corresponding to the mobile phase parameter conditions delivered respectively, and then after the parameter conditions of the first mobile phase flow are intermittently delivered in a predetermined amount of discrete increments, the resin / adsorbent is sequentially contacted with at least one second mobile phase flow, and a desired new mass transfer equilibrium contact method is achieved with the discrete incremental parameter conditions, so that at least one component is sequentially desorbed separately from the resin / adsorbent;

[0072] A256: intermittently delivering a plurality of at least one predetermined amount of a second mobile phase stream to an inlet of the integral unit during a predetermined first time period;

[0073] A257: During a predetermined second time period, after each delivery of the second mobile phase, intermittently supplying pressurized inert gas to the top of the integral unit to rapidly push the delivered second mobile phase through the resin / adsorbent installed in the integral unit, and at the same time, maintaining a vacuum environment on the other side of the integral unit where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state;

[0074] A258: Collects most of the processed mobile phase liquid material from the outlet at the bottom of the monolithic unit;

[0075] A259: The total time spent in steps A256-A258 is defined as the minimum time interval, also known as the second discrete mobile phase region;

[0076] A260: repeating step A259 by increasing the discrete increments of the mobile phase parameter conditions until all adjusted at least one second mobile phase flow is sequentially delivered with a preset increment discrete and total cumulative minimum time interval being a plurality of second discrete mobile phase zones, which are sequentially named corresponding to the mobile phase parameter conditions delivered respectively, and then after the parameter conditions of the second mobile phase flow are intermittently delivered in a predetermined amount of discrete increments, the resin / adsorbent is sequentially contacted with at least one third mobile phase flow, and a desired new mass transfer equilibrium contact method is achieved with the discrete increment parameter conditions, so that at least one component is sequentially desorbed separately from the resin / adsorbent;

[0077] A261: intermittently delivering a predetermined amount of at least one of the discharged and collected third mobile phase flows to an inlet of the integrated unit during a predetermined first time period;

[0078] A262: During a predetermined second time period, after each delivery of the third mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit so as to rapidly push the delivered third mobile phase through the resin / adsorbent installed in the integral unit, and at the same time, a vacuum environment is maintained on the other side of the integral unit where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state;

[0079] A263: Collects most of the processed mobile phase liquid material from the outlet at the bottom of the monolithic unit;

[0080] A264: The total time spent in steps A261-A263 is defined as the minimum time interval, also known as the third discrete mobile phase region;

[0081] A265: repeating step A264 by increasing the discrete increments of the mobile phase parameter conditions until all the adjusted at least one third mobile phase flow is discretely carried out by the preset increments delivered in sequence, and the total cumulative minimum time interval is a plurality of third discrete mobile phase zones, which are named in sequence corresponding to the mobile phase parameter conditions delivered respectively, if the remaining components are still adsorbed by the resin / adsorbent, adding at least one fourth mobile phase flow so that the components can be eluted by a predetermined composition, the discrete increments of the mobile phase parameter conditions are adjusted to achieve the expected new mass transfer equilibrium contact method, so that the remaining components are sequentially desorbed from the resin / adsorbent separately, if the remaining components are not adsorbed by the resin / adsorbent, entering step A266;

[0082] A266: intermittently delivering at least one predetermined amount of the first mobile phase flow discharged and collected in step A253 to the inlet of the integrated unit within a predetermined first time period;

[0083] A267: During a predetermined second time period, after each delivery of the first mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit, and at the same time, a vacuum environment is maintained on the other side of the integral unit where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state;

[0084] A268: Collects most of the processed mobile phase liquid material from the outlet at the bottom of the monolithic unit;

[0085] A269: Define the total time spent in steps A266-A268 as the minimum time interval;

[0086] A270: repeating step A269 until all at least one first mobile phase flow is delivered in sequence and the total cumulative minimum time interval is the last discrete mobile phase zone;

[0087] A271: Finally, all defined regions are integrated in turn according to the mobile phase parameter conditions in the time domain, so that the characteristic separation curve of a specific separation system can be obtained by inputting the II mode;

[0088] Wherein, the second mobile phase flow and the third mobile phase flow both include a liquid eluent of a predetermined composition.

[0089] Preferably: the parameter differential moving bed is used to separate a component and at least one other component from a feed solution mixture containing one component and at least one other component dissolved in an eluent, and it utilizes a new mass transfer equilibrium contact method, through a selected combination of mobile phase and solid phase resin / adsorbent, to obtain a characteristic elution curve between selected SI mode and II mode, and the characteristic elution curve is used to establish a differential setting program, and the specific steps are: adopting the general procedure of the new mass transfer equilibrium contact method, implementing the differential setting program on the parameter differential moving bed through a single-stage recovery procedure, and then using the new mass transfer equilibrium contact method together with the mobile phase liquid flow transmission mechanism.

[0090] Preferably: the upstream storage tank module comprises an insulating jacket, a plurality of upper storage tanks of different sizes arranged inside the insulating jacket, and all the upper storage tanks are arranged in an organized array in a selected pattern; the top surface of the upper storage tank is provided with an inlet conduit penetrating the outer wall of the insulating jacket and extending upward, and the bottom end of the inlet conduit is provided with a baffle a; the bottom surface of the upper storage tank is provided with an outlet conduit penetrating the outer wall of the insulating jacket and extending downward, and the top end of the outlet conduit is provided with a baffle b;

[0091] The insulating jacket includes manifold A and manifold B.

[0092] Preferably: each of the upper storage tanks comprises at least a portion of the feed solution, an eluent of a specific recovery mixture having a specific composition, and the eluent;

[0093] The plurality of upper storage tanks include at least one feed tank and at least one eluent tank, wherein the feed tank includes a portion of the feed solution evenly distributed from the total feed solution throughput, and all feed tanks are integrated into a feed zone; the eluent tank includes eluent and a modified eluent composition, and the eluent composition includes selected discrete increments of parameter conditions for respective eluent components;

[0094] The modified eluent composition includes an eluent selected under discrete increasing parameter conditions, at least one different modified eluent is orderly arranged between a plurality of modified eluents, each eluent has a composition preset before the isopoint of the components, the modified eluent sequentially desorbs at least one of the first other components, and does not elute the adsorbed component and the remaining at least one other component, a plurality of recovery mixtures having specific compositions dissolved in the eluent discharged for recovery, and orderly contained in a plurality of upper storage tanks as at least one first elution zone;

[0095] At least one modified eluent is arranged in an orderly manner with at least one incremental parameter condition, each eluent having a preset modified composition sequentially desorbs at least a portion of the component to a maximum desorbed portion, and does not elute at least one other component remaining adsorbed, a plurality of recovery mixtures having a specific composition of the components dissolved in the eluent discharged for recovery, orderly contained in a plurality of upper storage tanks as at least one component recovery zone and named as at least one product recovery zone;

[0096] at least one modified eluent is sequentially arranged with at least one incremental parameter condition, each eluent having a preset isopoint composition at each time, above the isopoint of one component with the isopoints of all other components, and capable of desorbing at least one remaining another component, dissolving such sequentially a plurality of recovery mixtures having a specific composition of components in the eluent discharged for recovery, sequentially contained in a plurality of upper storage tanks as at least a second elution zone and named a regeneration zone;

[0097] and at least one eluent containing the eluent itself for washing off the resin / adsorbent in contact with the feed liquid in the feed zone, sequentially contained in the plurality of upper storage tanks and named as the wash zone;

[0098] The adjusted mobile phase eluent having a discrete isopoint equilibrium differential state under parameter conditions is orderly contacted with the resin / adsorbent installed in the integral unit, and the single adsorbed components having the corresponding discrete isopoint equilibrium differential state in contact with the surrounding are sequentially eluted, and the corresponding adjusted eluents in all the integral units are integrated; the adjusted eluent is mixed with the contacted particulate reversed phase resin / adsorbent, including a deionized pure water eluent, and the eluent is mixed with an organic solvent with a lower polarity to reduce the polarity of the adjusted eluent, and when the eluent is mixed with the organic solvent with a lower polarity, the volume percentage of the selected organic solvent is increased by 5% to 95% by volume for mixing;

[0099] Alternatively: the eluent is adjusted to contact with the particulate normal phase resin / adsorbent, including a non-polar solvent eluent, and the eluent is mixed with a more polar organic solvent to increase the polarity of the adjusted eluent, thereby increasing the solubility of the adsorbed components to desorb and elute back into the surrounding adjusted mobile phase eluent.

[0100] Preferably: the upstream rotary connection module comprises a circular multi-valve body I controlled and driven by a driving member I, and the driving member I is a servo motor I and a brake I;

[0101] The circular multi-valve body I comprises a horizontal circular plate a, a stretching rod a fixedly connected to the inner wall of the horizontal circular plate a, a plurality of storage containers arranged in a circular array on the top surface of the horizontal circular plate a, and a plurality of liquid outlet conduits arranged in a circular array on the bottom surface of the horizontal circular plate a. The bottom end of the stretching rod a is connected to the output end of the driving member I through a coupling, and a pressure-activated spring valve a is arranged on the top outer wall of the liquid outlet conduit;

[0102] The top surface of the storage container is fixedly connected with an inlet end, and the number of storage containers and outlet conduits is the same, and they are connected one-to-one through the conduits;

[0103] The top surface of the horizontal circular plate a is fixedly connected with an annular channel a with a 'U'-shaped cross section, and the storage container is arranged inside the annular channel a; the top surface of the annular channel a is fixedly connected with a joint a, and the joint a is connected with the outlet conduit, and the output end of the joint a is connected with the top end of the inlet end through the liquid conduit D after passing through the upper surface of the annular channel a, and the liquid conduit D is arranged inside the annular channel a;

[0104] A baffle h is fixedly connected to the inner wall of the storage container near the top;

[0105] The inner circumferential wall of the annular channel a is fixedly connected with an inner top railing a and an inner bottom railing a that match each other up and down, and the inner bottom railing a is fixedly connected to the top surface of the horizontal circular plate a; the outer circumferential wall of the annular channel a is fixedly connected with an outer top railing a and an outer bottom railing a that match each other up and down, and the outer bottom railing a is fixedly connected to the top surface of the horizontal circular plate a;

[0106] The top surface of the inner top rail a is fixedly connected with the inner rim a, and the top surface of the outer top rail a is fixedly connected with the outer rim a; the inner walls of the concentric cavities respectively formed between the inner top rail a and the inner bottom rail a and between the outer top rail a and the outer bottom rail a are filled with a plurality of balls a; an upper semi-elliptical groove is provided at the center of the bottom surface of the outer top rail a, which matches the lower semi-elliptical groove provided at the center of the top surface of the outer bottom rail a, and the upper semi-elliptical groove and the lower semi-elliptical groove are buckled to form the same concentric elliptical tunnel, and the diameter of the ball a is slightly larger than the vertical height of the concentric elliptical tunnel, thereby forming a gap a;

[0107] The inner top railing a and the outer top railing a are provided with a semicircular groove a and a semicircular groove c on both sides of the bottom surface, the inner bottom railing a and the outer bottom railing a are provided with a semicircular groove b and a semicircular groove d on both sides of the top surface, and concentric circular tunnels a and concentric circular tunnels b are formed between the inner top railing a and the inner bottom railing a and between the outer top railing a and the outer bottom railing a, respectively, and the inner walls of the concentric circular tunnels a and the concentric circular tunnels b are filled with ring-shaped sealing members respectively;

[0108] The bottom surface of the horizontal circular plate a is fixedly connected with an annular fixed chamber a having the same structure as the annular channel a, and the gap between the annular fixed chamber a and the horizontal circular plate a is infinitely small;

[0109] The bottom inner wall of the annular fixed chamber a is fixedly connected with funnels a, the number of which is the same as that of the storage containers and the upper and lower positions of which are corresponding; the bottom outer wall of the annular fixed chamber a is fixedly connected with a joint b, the joint b is connected to the outlet of the funnel a, the funnel a is connected to the liquid outlet conduit, and a liquid conduit C is arranged between the joint b and the storage container.

[0110] Preferably: the separation module comprises a plurality of integral units arranged inside the interlayer sleeve, and a plurality of single columns arranged inside the integral units;

[0111] The top surface of the integral unit is provided with a reservoir, the top end of the reservoir penetrates the top surface of the interlayer sleeve and extends upward, the top end of the reservoir is provided with a baffle c, the baffle c comprises a circular rigid material arranged on the inner wall of the circumference of the rigid sealing gasket, the top surface of the baffle c is fixedly connected with a rigid steel wire, the outer wall of the rigid steel wire is fixedly connected with a circular channel, the inner wall of the baffle c is provided with a rigid central rod, the top end of the rigid central rod is inserted into the interior of the circular channel;

[0112] The inner wall of the storage container is provided with a circular compartment, the circular compartment includes a circular opening a and a circular opening b opened on the outer wall thereof, and a side channel;

[0113] A baffle d is provided between the bottom end of the reservoir and the top end of the nozzle fixedly connected to the inner wall of the top of the integral unit, and a baffle j is fixedly connected to the bottom surface of the baffle d, and the liquid distributor is the nozzle;

[0114] The outer wall of the storage container between baffles c and d is provided with a pipeline three;

[0115] The interior of the interlayer sleeve is provided with more than two vertically mounted partitions, and the interlayer sleeve includes a manifold C and a manifold D;

[0116] The bottom surface of the integral unit is connected to a vacuum box, one side of the vacuum box is provided with an air outlet pipe, and one side of the vacuum box is provided with a manifold E; a liquid reservoir is provided inside the vacuum box;

[0117] The bottom surface of the integral unit is provided with a funnel-shaped liquid collecting conduit, and the bottom inner wall of the liquid collecting conduit is provided with a baffle e;

[0118] A liquid conduit A is provided at the bottom end of the liquid reservoir, a baffle f is provided inside the liquid conduit A, a pipe five is provided on the circumferential outer wall of the liquid conduit A below the baffle f, and the pipe five extends outwardly through one side of the interlayer sleeve; a pressure-activated check valve b is provided on the circumferential outer wall of the liquid conduit A near the top.

[0119] Preferably: the top surface of the single column is provided with an inlet end, the bottom surface of the single column is provided with an outlet end, and a mesh filter is provided inside the outlet end; the single column retains a determined amount of resin / adsorbent solid material, corresponding to the amount of resin / adsorbent installed as a mass transfer zone in the chromatogram;

[0120] Alternatively, the single column includes a plurality of stacking rings, a mesh filter is provided at the bottom of the stacking ring to prevent the granular resin / adsorbent material from being discharged, and an independent space is left between two adjacent stacking rings, an inlet end is opened at the top of the stacking ring, the resin / adsorbent content in each stacking ring is different, and the resin / adsorbent filler in the stacking ring is a combination of anion exchanger, cation exchanger, reverse phase, normal phase, activated carbon and catalyst.

[0121] Preferably: the downstream rotary connection module comprises a circular multi-valve body II controlled and driven by a driving member II, and the driving member II comprises a servo motor II and a brake II;

[0122] The circular multi-valve body II comprises a horizontal circular plate b, a stretching rod b fixedly connected to the inner wall of the horizontal circular plate b, a plurality of transfer containers arranged in a circular array on the top surface of the horizontal circular plate b, and a plurality of output conduits arranged in a circular array on the bottom surface of the horizontal circular plate b and equal in number to the transfer containers. The bottom end of the stretching rod b is connected to the output end of the driving member II through a coupling; a pressure-activated spring valve b is arranged on the top outer wall of the transfer container, and an open end is fixedly connected to the top surface of the transfer container;

[0123] The top surface of the horizontal circular plate b is fixedly connected with an annular channel b with a 'U'-shaped cross section, and the transfer container is arranged inside the annular channel b; the top surface of the annular channel b is fixedly connected with a joint c, and the joint c is connected with the liquid conduit A, and the output end of the joint c is connected with the top end of the opening end through the liquid conduit E after passing through the upper surface of the annular channel b;

[0124] A baffle i is fixedly connected to the inner wall of the transfer container near the top;

[0125] The bottom surface of the horizontal circular plate b is fixedly connected with an annular fixed chamber b having the same structure as the annular channel b, and the gap between the annular fixed chamber b and the horizontal circular plate b is infinitely small; the bottom inner wall of the annular fixed chamber b is fixedly connected with funnels b having the same number as the transfer container and corresponding upper and lower positions; the bottom outer wall of the annular fixed chamber b is fixedly connected with a joint d, the joint d is connected with the outlet of the funnel b, and the funnel b is connected with the output conduit;

[0126] The inner circumferential wall of the annular channel b is fixedly connected with an inner top railing b and an inner bottom railing b that match each other up and down, and the inner bottom railing b is fixedly connected to the top surface of the horizontal circular plate b; the outer circumferential wall of the annular channel b is fixedly connected with an outer top railing b and an outer bottom railing b that match each other up and down, and the outer bottom railing b is fixedly connected to the top surface of the horizontal circular plate b;

[0127] The top surface of the inner top rail b is fixedly connected to the inner rim b, and the top surface of the outer top rail b is fixedly connected to the outer rim b; the inner walls of the concentric cavities respectively formed between the inner top rail b and the inner bottom rail b and between the outer top rail b and the outer bottom rail b are filled with a plurality of balls b; an upper semi-arc groove is provided at the center of the bottom surface of the outer top rail b, which matches the lower semi-arc groove provided at the center of the top surface of the outer bottom rail b, and the upper semi-arc groove and the lower semi-arc groove are buckled to form the same concentric tunnel, and the diameter of the ball b is slightly larger than the vertical height of the concentric tunnel, thereby forming a gap b;

[0128] The inner top railing b and the outer top railing b are respectively provided with a semicircular groove e and a semicircular groove h on both sides of the bottom surface, the inner bottom railing b and the outer bottom railing b are respectively provided with a semicircular groove f and a semicircular groove h on both sides of the top surface, concentric circular tunnels c and concentric circular tunnels d are respectively formed between the inner top railing b and the inner bottom railing b and between the outer top railing b and the outer bottom railing b, and the inner walls of the concentric circular tunnels c and the concentric circular tunnels d are respectively filled with O-ring seals.

[0129] Preferably: the downstream storage tank module comprises a plurality of hollow sleeves distributed in an array, and a lower storage tank disposed inside the hollow sleeves, and the hollow sleeves are arranged in an organized array in a selected pattern;

[0130] The top surface of the lower storage tank is provided with an infusion conduit penetrating the outer wall of the hollow sleeve and extending upward, and a baffle g is provided at the top of the infusion conduit;

[0131] The top surface of the lower storage tank is provided with a pipeline 6;

[0132] The bottom surface of the lower storage tank is provided with a drainage pipe penetrating the outer wall of the hollow sleeve and extending downward, and the drainage pipe is connected to the volumetric pump;

[0133] A liquid level sensor is arranged inside the lower storage tank, and a liquid infusion tube is arranged on the top surface of the lower storage tank;

[0134] The lower storage tank includes a manifold F and a manifold G.

[0135] Preferably: the lower storage tank comprises at least one product storage tank for storing a specific concentrated component product, at least one by-product storage tank for storing at least one other concentrated component by-product, and a plurality of recovered mixtures sequentially contained in the lower storage tank;

[0136] During each duration of the time period, the discharged liquid is distributed to one of the corresponding upper tanks arranged in the upstream tank module, which contains:

[0137] ① a liquid having a specific composition of components dissolved in the discharge solution and the eluent, which liquid is the composition of the components contained in the discharged liquid for recovery;

[0138] ② When delivered in sequence within a specific time period, the liquid from all liquids including the feed solution and the recovered mixture of the discharged liquid and the eluent collected within the same time period, i.e. the specific composition of the components dissolved in the discharged solution and the eluent, are respectively distributed to the corresponding one of the upper storage tanks, all of which are the composition of the components contained in the discharged liquid, and are arranged in the corresponding areas including the feed area, the regeneration area and the washing area in the specified order;

[0139] The lower storage tank in the downstream storage tank module contains a specific recovery mixture having a specific composition of components dissolved in the effluent solution and the eluent for recovery, at least one product storage tank for holding a specific concentrated component product and a by-product storage tank for holding at least one other concentrated component by-product.

[0140] Preferably; the inert gas supply module supplies a wide range of pressurized inert gas by establishing a closed loop, providing a mobile phase liquid flow transmission mechanism, including combining an upstream storage tank module, an upstream rotary module, a separation module, a downstream rotary module and a downstream storage tank module with liquid fluid transmission; the inert gas supply module includes a closed vacuum environment loop that is sequentially connected to form a closed loop and is arranged at the bottom of the overall unit, an upstream wide-area inert gas supply loop and a downstream wide-range inert gas supply loop that are arranged at the top of the overall unit;

[0141] The closed vacuum environment loop includes an aerosol separator, a liquid reservoir, a central vacuum pump, a water reservoir, a liquid guide tube fixedly connected to the bottom surface of the water reservoir, an inert gas generator and a steel tank container. The gas outlet of the aerosol separator is connected to the central vacuum pump and one end of the water reservoir through a conveying conduit, and the inlet and outlet ends of the inert gas generator are respectively connected to the gas outlet end of the central vacuum pump and the gas inlet end of the steel tank container; the gas inlet of the aerosol separator is connected to a manifold P, and the output end of the manifold P is connected to the input ends of multiple gas outlet pipes; the vacuum degree of the closed vacuum environment loop is 15 to 27 in-Hg;

[0142] The upstream wide-area inert gas supply loop includes a one-way gas pipeline connected to the medium-pressure gas outlet of the steel tank container, a manifold H connected to the second input end of the pipeline and the output end of the one-way gas pipeline, a two-way gas pipeline connected to the low-pressure gas outlet of the steel tank container, a manifold J connected to the first input end of the pipeline and the output end of the second gas pipeline, a three-way gas pipeline connected to the high-pressure gas outlet of the steel tank container, a manifold K connected to the third input end of the pipeline and the output end of the three-way gas pipeline, an online gas temperature regulator connected to the output end of the steel tank container at one end, a four-way gas pipeline connected to the output end of the online gas temperature regulator, and a manifold L connected to the fourth input end of the pipeline and the output end of the four-way gas pipeline, wherein the fourth pipeline is arranged on the top surface of the integral unit, the second pipeline is arranged on the circumferential outer wall of the outlet conduit, and the first pipeline is arranged on the top outer wall of the upper storage tank;

[0143] The downstream wide-range inert gas supply loop includes a five-way gas pipeline connected to the other medium-pressure gas outlet end of the steel tank container, a manifold M connected to the fifth input end of the pipeline and the output end of the five-way gas pipeline, a six-way gas pipeline connected to the other high-pressure gas outlet end of the steel tank container, and a manifold N connected to the sixth input end of the pipeline and the output end of the six-way gas pipeline.

[0144] Preferably: the inert gas is one of nitrogen, carbon dioxide, argon and air, or a mixture of gases; the pressure level of the mid-range pressurized inert gas in the upstream tank module is 55-70psi; the pressure level of the low-range pressurized inert gas in the upstream tank module is 40-55psi; the pressure level of the low-range pressurized inert gas in the separation module is 40-55psi; the pressure level of the mid-range pressurized inert gas in the separation module is 55-70psi; the pressure level of the high-range pressurized inert gas in the downstream tank module is 70-90psi.

[0145] Preferably: the differential setting procedure includes setting at least one region corresponding to at least one first mobile phase flow, setting at least one region corresponding to at least one second mobile phase flow, setting at least one region corresponding to at least one third mobile phase flow, and a predetermined plurality of alternative circulating mobile phase flows returning to the predetermined region;

[0146] The differential setting program includes a predetermined plurality of alternative recycled mobile phase flows for intermittent delivery to the parametric differential moving bed; wherein the mobile phase flow is a replacement for at least one first mobile phase flow stored in a corresponding upper storage tank in an upstream storage tank module;

[0147] Or: the mobile phase flow replaces at least one corresponding second mobile phase flow stored in a corresponding upper storage tank in the upstream storage tank module;

[0148] Or: the mobile phase flow replaces at least one corresponding third mobile phase flow stored in a corresponding upper tank in the upstream tank module.

[0149] Preferably: the differential setting procedure applied to the parameter differential moving bed comprises the following steps:

[0150] B1: Determine the optimal full-strength adsorption capacity of the resin / adsorbent at a predetermined feed throughput and divide the optimal full-strength adsorption capacity by a pre-selected number;

[0151] The optimal full strength adsorption amount divides the resin / adsorbent into equal sub-amounts in at least one single column disposed in a single integral unit; the preselected number of numbers is equal to the number of single columns disposed in the single integral unit in each region;

[0152] B2: In the general procedure of the new mass transfer equilibrium contact method, between the selected input modes SI mode and II mode, a characteristic elution curve represented in the time domain is generated according to a predetermined type of liquid distributor, by intermittently delivering a predetermined volume of a feed solution containing one component and at least one other component into the integral unit, and then by the general procedure of the new mass transfer equilibrium contact method, after the introduction of the feed solution, by intermittently delivering a plurality of circulating streams and eluents of predetermined volumes in a specific order, the adsorbed components are sequentially eluted to obtain at least one specific concentrated product component, to obtain another concentrated component of at least one by-product, and to obtain a plurality of recovered mixtures;

[0153] B3: Decompose the elution curve sequentially by sub-times in the total cumulative time domain, and then divide each sub-time by the minimum time interval to obtain the range of the number of overall cells set as the corresponding region;

[0154] B4: Divide the total input volume of the mobile phase solution by the number of the whole units to obtain the partial volume required for each minimum time interval in the corresponding area, and then divide the partial volume by a pre-selected number to further distinguish as multiple continuous liquid drop amounts;

[0155] B5: All integral units with each liquid are assigned to the range of the specific liquid area;

[0156] B6: Arrange all liquid zones in the same order in a parametric differential moving bed in an infinite cycle for various transported liquids;

[0157] B7: Predetermined volumes of various specific recovery mixtures in step B2 are sequentially prepared into corresponding lower storage tanks in the downstream storage tank module to support liquid distribution through a closed loop of the upstream storage tank module, the upstream rotary module, the separation module, the downstream rotary module, and the downstream storage tank module, and then returned to the downstream storage tank module through the driving force provided by the mobile phase liquid flow transmission mechanism;

[0158] The preselected number is a finite integer ≥ 1. When the integer = 1, B1 contains a predetermined amount of solid phase resin / adsorbent as a single integral unit distributed in a single column.

[0159] Preferably, the B6, all regions arranged in the same order are integrated and combined, and the specific operation is:

[0160] B61: providing at least one region between the selectively introduced at least one amount of the first mobile phase flow and the plurality of first discrete mobile phase flows, in contact with the installed resin / adsorbent packing in the time domain, to perform the intended mass transfer contact as the first mobile phase region;

[0161] B62: providing at least one region between the selective introduction of at least one amount of the second mobile phase flow and the plurality of second discrete mobile phase flows, in contact with the installed resin / adsorbent packing in the time domain, to perform the intended mass transfer contact as the second mobile phase region;

[0162] B63: providing at least one region between the selective introduction of at least one amount of the third mobile phase flow and the plurality of third discrete mobile phase flows, in contact with the disposed resin / adsorbent filler in the time domain, to perform the intended mass transfer contact as the third mobile phase region;

[0163] B64: at least one region is provided between the selective introduction of at least one amount of a fourth and a fifth mobile phase flow and a plurality of fourth and a fifth discrete mobile phase flows, in contact with the disposed resin / adsorbent filler in the time domain for the intended mass transfer contact, as a corresponding fourth, fifth ... and so on, until all adsorbates in the mobile phase region are sequentially eluted;

[0164] B65: setting at least one zone corresponding to the introduction of at least one last mobile phase flow in contact with the treated resin / adsorbent packing in the time domain to perform the expected mass transfer contact as the last mobile phase zone;

[0165] B66: and predetermined multiple replacement circulating mobile phase flows return to the predetermined above-mentioned areas to replace the solutions set in the above-mentioned corresponding areas, so as to increase the concentration of the separated components and save the consumption of the corresponding solutions;

[0166] B67: The entire area of ​​each region of the tissue is sequentially integrated to obtain a characteristic separation curve for eliminating chromatographic displacement zones and further arranging this difference scheme.

[0167] Preferably: the single-stage recovery procedure simultaneously transmits all kinds of liquids on a parameter differential moving bed through a general procedure of a new mass transfer equilibrium contact method and a differential setting procedure between two phases for simultaneously recovering multiple streams and eluents.

[0168] Preferably, the single-stage recovery procedure is adopted in a parameter differential moving bed to achieve the following separation process:

[0169] Ⅰ: Keep all upper tanks in the upstream tank module within the selected temperature range, where:

[0170] ① at least one upper storage tank is arranged in the first mobile phase area, each upper storage tank contains at least one predetermined selected first mobile phase flow and a plurality of first discrete mobile phase flows;

[0171] ② at least one upper storage tank is arranged in the second mobile phase area, each upper storage tank contains at least one predetermined selected second mobile phase flow and a plurality of second discrete mobile phase flows;

[0172] ③ installing at least one upper storage tank in the third mobile phase zone, each upper storage tank containing at least one predetermined selected third mobile phase flow and a plurality of third discrete mobile phase flows;

[0173] ④ at least one upper storage tank is arranged in the fourth, fifth, and so on mobile phase zones, each upper storage tank containing at least one predetermined fourth, fifth mobile phase flow and a plurality of fourth, fifth discrete mobile phase flows;

[0174] ⑤ at least one upper storage tank disposed in the last mobile phase zone, each upper storage tank containing at least one predetermined selected last discrete mobile phase flow;

[0175] II: Keep all lower tanks in the downstream tank module within the selected temperature range, where:

[0176] At least one lower storage tank is allocated to receive liquid delivered from a specific upper storage tank, the upper storage tank is arranged in an upstream storage tank module of a first mobile phase zone, at least one predetermined first mobile phase flow and a plurality of first discrete mobile phase flows are contacted with a resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method;

[0177] At least one lower storage tank is designated to receive liquid delivered from a specific upper storage tank, the upper storage tank is disposed in an upstream storage tank module of a second mobile phase zone, at least one predetermined second mobile phase flow and a plurality of second discrete mobile phase flows are contacted with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method;

[0178] At least one lower storage tank is designated to receive liquid delivered from a specific upper storage tank, the upper storage tank is disposed in an upstream storage tank module of a third mobile phase zone, at least one predetermined selected third mobile phase flow and a plurality of third discrete mobile phase flows are contacted with the resin / adsorbent solid phase packing to achieve a new mass transfer equilibrium contact method;

[0179] At least one lower storage tank is designated to receive liquid delivered from a specific upper storage tank of an upstream storage tank module disposed in the fourth and fifth mobile phase zones, and at least one predetermined selected fourth and fifth mobile phase streams and a plurality of fourth and fifth discrete mobile phase streams are contacted with the resin / adsorbent solid phase filler to obtain a new mass transfer equilibrium contact method;

[0180] at least one lower storage tank is designated to receive liquid delivered from a specific upper storage tank, the upper storage tank being disposed in the last mobile phase zone of the upstream storage tank module, at least one predetermined last mobile phase flow and last discrete mobile phase flow contacting the resin / adsorbent solid phase packing to clean and wash away the residual resin / adsorbent solid packing;

[0181] according to - The steps of allocating at least one product storage tank for holding a specific concentrated component product, at least one byproduct storage tank for holding at least one other concentrated component byproduct, and then preparing each circulating liquid stream based on the obtained elution profile, the composition of dissolved limiting solutes specifically modifying the characteristic parameters of the eluent solution mixture;

[0182] III: The single integral unit is further operated together with the mobile phase liquid flow transmission mechanism through the new mass transfer equilibrium contact method, and each mobile phase liquid stored in the corresponding area of ​​the corresponding upper storage tank is sequentially dripped into the separation module in a predetermined volume format in the above order to produce the expected new mass transfer equilibrium contact method, and the liquid is continuously delivered according to the repetitive procedure after each drop, and once the predetermined amount of liquid solution is completed, it is distributed and delivered to the reservoir at the top of the single integral unit, wherein:

[0183] a) in a first time period, intermittently delivering a forced discharge dose of liquid dripping from the top of a single integral unit through an alternating supply mode between two separate wide range pressurized inert gas routes to rapidly pass through the resin / adsorbent to complete a new mass transfer equilibrium contact method between the two phases to promote the adsorption of components onto the resin / adsorbent or to elute the adsorbed components from the resin / adsorbent;

[0184] 2) while maintaining the vacuum environment at the bottom of the overall unit, draining the treated liquid solution into the reservoir below and keeping the resin / adsorbent in a semi-dry state;

[0185] 3) during the second time period, intermittently collecting the discharged liquid in the liquid reservoir and delivering the collected liquid to each designated lower storage tank in the downstream storage tank module;

[0186] iv) repeating steps 1) to 3) to complete all liquids disposed in at least one upper storage tank disposed in the first mobile phase zone, and transferring the liquid collected from the bottom of the integral unit as a circulating flow to a designated lower storage tank of the last mobile phase zone;

[0187] 5) repeating steps 1) to 3) to complete all the liquids disposed in at least one upper storage tank disposed in the second mobile phase zone, and transferring the liquid collected from the bottom of the integral unit back to the designated lower storage tank of the second mobile phase zone as a circulating flow;

[0188] vi) repeating steps 1) to 3) to complete all liquids disposed in at least one upper storage tank (15) disposed in the third mobile phase zone, and transferring the liquid collected from the bottom of the integral unit (95) back to the designated lower storage tank (44) of the third mobile phase zone as a circulating flow;

[0189] VII) repeating steps 1) to 3) to complete the placement of all liquids in at least one upper storage tank, the upper storage tank being placed in the fourth and fifth mobile phase zones, through which the liquid collected from the bottom of the integral unit is transferred as a circulating flow back to the corresponding fourth, fifth, etc. mobile phase zones designated lower storage tanks;

[0190] VIII) repeating steps 1) to 3) to complete the setting of all liquids, at least one upper storage tank being set in the last mobile phase zone, through which the liquid collected from the bottom of the integral unit is transferred as a circulating flow back to the designated lower storage tank of the first mobile phase zone;

[0191] The mobile phase comprises a feed liquid mobile phase of at least one desired component and a solute mixture separated from at least one other component as a uniform liquid solution mixture of finite components; the solute composition is dissolved in the solution in discrete increments of parameters with increasing discrete parameters so as to achieve a desired new mass transfer equilibrium contact method so that at least one of the components can be sequentially desorbed from the resin / adsorbent.

[0192] Preferably, the operation content of the single-stage recovery procedure includes the following supplements:

[0193] C1: The liquid is transported in a closed loop, starting from the downstream tank module, through the upstream tank module attached to the pressurized inert gas supply module, as well as the rotating and positioning device and the sealing mechanism in the upstream rotary module, completing the new mass transfer equilibrium contact method in the separation module, and then returning to the downstream tank module through the rotating and positioning device together with the sealing mechanism in the downstream rotary module;

[0194] C2: Steady-state operating procedures during each time interval spent;

[0195] C3: Restoring to a fresh semi-dry state in a parameter differential moving bed for termination operation;

[0196] The C1 step also includes the following:

[0197] C11: the integral unit located at the first position in the separation module receives a predetermined volume of liquid delivery, while the remaining integral units do not receive liquid;

[0198] C12: After each simultaneous delivery of various liquids in a predetermined volume sequence, the liquids are delivered intermittently by alternating the supply between two separate wide-range pressurized inert gas paths to force the dripping dosed liquid to be discharged quickly after passing through the resin to complete the expected new mass transfer equilibrium contact method between the solid phase and the liquid phase;

[0199] C13: while maintaining a closed vacuum environment, each treated liquid solution is discharged into a corresponding transfer container, so that the resin / adsorbent in the overall unit is in a semi-dry state;

[0200] C14: intermittently collects the discharged liquid from each transfer container and transmits each collected liquid to the lower storage tank through the downstream spin-on module via an extensive pressurized inert gas supply route;

[0201] C15: Repeat steps C11-C14, and simultaneously cover the first integral unit and the second integral unit receiving liquid in the separation module, until the first receiving liquid arranged in the upstream rotary module and the first receiving liquid in the transfer container arranged in the downstream rotary module return to their initial positions, and one rotation cycle is completed, and the startup operation is completed;

[0202] the various liquids recovered in said startup operation as one specific concentrated component of at least one product in the product storage tank, and another concentrated component of at least one byproduct in each byproduct storage tank, a plurality of recovered mixtures, wherein one specific recovered mixture has a specific composition of components dissolved in the drain solution, and the eluents held in each storage tank in a specific order;

[0203] The content of the steady-state operation procedure in C2 includes the following steps:

[0204] C21: Liquid delivery by means of a wide range of pressurized inert gases, delivering predetermined volumes of various liquids in various circulating streams, while simultaneously delivering all available liquid from an upper storage tank, which is forced into storage vessels through various pressurized inert gas supply routes;

[0205] C22: After delivering various liquids, intermittent delivery is performed by alternating supply between two separate wide range pressurized inert gas paths to force the dripping dosed liquid to be discharged quickly after passing through the resin / adsorbent to complete the expected new mass transfer contact equilibrium method between the solid phase and the liquid phase;

[0206] C23: while maintaining a closed vacuum environment, each treated liquid solution is discharged into a corresponding transfer container, so that the resin / adsorbent disposed in each integral unit is in a semi-dry state;

[0207] C24: intermittently collects various discharged liquids from each transfer container and transfers the collected liquids to the lower storage tank through the downstream spin-on module via a wide range of pressurized inert gas supply routes;

[0208] the various liquids recovered in said steady state operating procedures as a specific concentrated component of at least one product in each product storage tank, and another concentrated component of at least one by-product in each by-product storage tank, various recovered mixtures [a specific recovered mixture in the mixtures having a specific composition of said components dissolved in the discharged solution], and the eluent held in each storage tank in a specific order;

[0209] The termination operation in C3 is used to generate the reverse operation procedure of the startup operation of the resin / adsorbent installed in the separation module. The specific content of the termination operation includes the following supplements:

[0210] C31: the integral unit located at the first position in the separation module stops receiving the predetermined volume of liquid delivery, while the remaining integral units continue to receive the liquid at the same time;

[0211] C32: After each simultaneous delivery of various liquids in a predetermined volume sequence, the liquids are delivered intermittently by alternating the supply between two separate wide-range pressurized inert gas paths to force the dripping dosed liquid to be discharged quickly after passing through the resin to complete the expected new mass transfer equilibrium contact method between the solid phase and the liquid phase;

[0212] C33: while maintaining a closed vacuum environment, the treated liquid solution is discharged into the corresponding transfer container, so that the resin / adsorbent in the overall unit is in a semi-dry state;

[0213] C34: intermittently collects the discharged liquid from each transfer container and transfers each collected liquid to the lower storage tank through the downstream spin-on module via an extensive pressurized inert gas supply route;

[0214] C35: repeat steps C31-C34, and simultaneously cover the first integral unit and the second integral unit receiving liquid in the separation module to stop receiving liquid, until the first receiving liquid arranged in the upstream rotary module and the first receiving liquid in the transfer container arranged in the downstream rotary module return to their initial positions, and one rotation cycle is completed, and the termination operation is completed;

[0215] In the single-stage recovery procedure, the wide range of pressure levels of the pressurized inert gas is 40-90 psi, wherein the low range of the pressurized inert gas pressure level is 40-55 psi, the medium range of the pressurized inert gas pressure level is 55-70 psi, and the high range of the pressurized inert gas pressure level is 75-90 psi.

[0216] Preferably, the heat medium in the insulating jacket, interlayer jacket and hollow jacket is water at a temperature of 0-100°C, wherein brine or a mixture of water and antifreeze is used for lower temperatures below 0°C; mineral oil is used for temperatures above 100°C.

[0217] Preferably: the general procedure of the new mass transfer equilibrium contact method is: the mobile phase liquid material is sequentially delivered through a predetermined type of liquid distributor, and a predetermined volume of the delivered fluid is conducted in a short time to be sprinkled into the wetting area of ​​the resin / adsorbent, thereby achieving the expected new mass transfer equilibrium contact method between the two phases.

[0218] Preferably, the single-stage recovery procedure is used in a parametric differential moving bed to achieve the following separation process applicable to a single integral unit:

[0219] Ⅰ: Keep all lower tanks in the downstream tank module within the selected temperature range, where:

[0220] At least one lower storage tank is allocated to receive the liquid collected and discharged from the matching specific multiple integral units, and the lower storage tank is arranged in the downstream storage tank module of the first mobile phase zone, and at least one predetermined first mobile phase flow and a plurality of first discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method;

[0221] At least one lower storage tank is allocated to receive the liquid collected and discharged from the matching specific multiple integral units, and the lower storage tank is arranged in the downstream storage tank module of the second mobile phase zone, and at least one predetermined second mobile phase flow and a plurality of second discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method;

[0222] At least one lower storage tank is allocated to receive the liquid collected and discharged from the matching specific multiple integral units, and the lower storage tank is arranged in the downstream storage tank module of the third mobile phase zone, and at least one predetermined third mobile phase flow and a plurality of third discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method;

[0223] At least one lower storage tank is allocated to receive the liquid collected and discharged from the matching specific multiple integral units, and the lower storage tank is arranged in the downstream storage tank module of the fourth and fifth mobile phase zones, and at least one predetermined fourth and fifth mobile phase flow and a plurality of fourth and fifth discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method;

[0224] At least one lower storage tank is allocated to receive the liquid collected and discharged from the matching specific multiple integral units, and the lower storage tank is arranged in the downstream storage tank module of the last mobile phase zone, and at least one predetermined last mobile phase flow and a plurality of last discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to clean and wash away the residual resin / adsorbent solid filler;

[0225] exist After the last lower storage tank of the last mobile phase zone in the middle, a lower storage tank is set to receive the corresponding pressurized inert gas from its source into the designated integral unit top reservoir to flush the remaining liquid in the resin / adsorbent solid phase packing to maintain a semi-dry state of the new mass transfer equilibrium contact method;

[0226] according to - The steps of allocating at least one product storage tank for holding a specific concentrated component product, at least one byproduct storage tank for holding at least one other concentrated component byproduct, and then preparing each circulating liquid stream based on the obtained elution profile, the composition of dissolved limiting solutes specifically modifying the characteristic parameters of the eluent solution mixture;

[0227] II: The plurality of integral units are further operated together with the mobile phase liquid flow transmission mechanism through the new mass transfer equilibrium contact method, and the mobile phase liquids stored in the corresponding areas of the corresponding lower storage tanks are simultaneously and sequentially dripped into the separation module in a predetermined volume format in the above order to produce the expected new mass transfer equilibrium contact method, and the liquid is continuously delivered according to the repetitive procedure after each drop, and once the predetermined amount of liquid solution is completed, it is distributed and delivered to the reservoirs at the top of each integral unit, wherein:

[0228] a) in a first time period, intermittently delivering a forced discharge dose of liquid dripping from the top of a single integral unit through an alternating supply mode between two separate wide range pressurized inert gas routes to rapidly pass through the resin / adsorbent to complete a new mass transfer equilibrium contact method between the two phases to promote the adsorption of components onto the resin / adsorbent or to elute the adsorbed components from the resin / adsorbent;

[0229] 2) while maintaining the vacuum environment at the bottom of the overall unit, draining the treated liquid solution into the reservoir below and keeping the resin / adsorbent in a semi-dry state;

[0230] 3) during the second time period, intermittently collecting the discharged liquid in the liquid reservoir and delivering the collected liquid to each designated lower storage tank in the downstream storage tank module;

[0231] iv) repeating steps 1) to 3) to complete all liquids disposed in at least one lower storage tank disposed in the first mobile phase zone, and transferring the liquid collected from the bottom of the integral unit as a circulating flow to a designated lower storage tank of the last mobile phase zone;

[0232] 5) repeating steps 1) to 3) to complete all the liquids disposed in at least one lower storage tank disposed in the second mobile phase zone, and transferring the liquid collected from the bottom of the integral unit back to the designated lower storage tank of the second mobile phase zone as a circulating flow;

[0233] vi) repeating steps 1) to 3) to complete all the liquids disposed in at least one lower storage tank disposed in the third mobile phase zone, and transferring the liquid collected from the bottom of the integral unit back to the designated lower storage tank of the third mobile phase zone as a circulating flow;

[0234] VII) repeating steps 1 to 3 to complete the placement of all liquids in at least one lower storage tank, the lower storage tank being placed in the fourth and fifth mobile phase zones, and the liquid collected from the bottom of the integral unit being transferred as a circulating flow back to the corresponding lower storage tank designated in the fourth, fifth, etc. mobile phase zones;

[0235] VIII) repeating steps 1) to 3) to complete the setting of all liquids, at least one lower storage tank being set in the last mobile phase zone, through which the liquid collected from the bottom of the integral unit is transferred back to the designated lower storage tank of the first mobile phase zone as a circulating flow;

[0236] The mobile phase simultaneously introduces a feed liquid mobile phase containing at least one desired component and at least one other component to separate a solute mixture as a uniform liquid solution mixture of limited components; the solute composition is dissolved in the solution in discrete increments of parameters with increasing discrete parameters so as to achieve a desired new mass transfer equilibrium contact method so that at least one of the components can be sequentially desorbed from the resin / adsorbent.

[0237] The beneficial effects of the present invention are:

[0238] 1. The present invention combines and applies differential settings, new mass transfer equilibrium contact methods, operating procedures and parameter differential moving beds, and integrates all stages into a complete separation cycle through continuous operation of simultaneous feeding, impurity stripping, adsorbent regeneration, washing and / or sanitation stages, so as to simultaneously separate at least one product stream and multiple impurities through stripping, regeneration and washing, and achieve the separation of specific target separation mixtures in a repetitive manner. The entire process is carried out by controlling various pressurized inert gases combined with the device to achieve the final separation of the large-scale production separation system and improve the maximum mass transfer efficiency. It can also be used in the binary separation system in the separation process of glucose and fructose, reduce the consumption of water washing liquid, and reduce the final power consumption.

[0239] 2. The present invention implements a new mass transfer equilibrium contact method, adopts a differential setting procedure between the two phases, switches the adsorbent and the mobile phase to fully use the adsorbent, thereby obtaining the maximum mass transfer efficiency between the two phases, and realizes a significant reduction in the resin / adsorbent inventory set in the device. The solid phase simulated to move in the horizontal direction is continuously and uniformly exposed, and simultaneously and in contact with multiple mobile phases in the vertical direction, the elution curve of the specific separation system is organized along the horizontal direction of the device to receive the mobile phase transmitted in the vertical direction, so as to simultaneously achieve a complete separation cycle within the duration of each time taking the shortest time interval.

[0240] 3. The present invention provides a new mobile phase input format to distinguish from chromatographic separation, such as general parameters such as pH value, polarity or ionic strength related to solubility, etc., wherein the input SI format is defined as a plurality of predetermined input volumes of the same mobile phase parameter condition being delivered simultaneously and intermittently in sequence to each cell set in a specific defined area during the duration of the minimum time interval; and the input II format is defined as a plurality of predetermined volumes of mobile phase parameter condition solutions being delivered simultaneously and intermittently in sequence to each integral cell located in the same specific defined area during the duration of the minimum time interval. The difference increment of each mobile phase condition is between two pre-specified levels, which are grouped with each cell in the area accordingly, and the input volume of each discrete mobile phase parameter condition is further divided into predetermined equal parts, and is therefore also associated with a specified cell in the area.

[0241] 4. The single-stage recovery scheme provided by the present invention utilizes the elution curve arranged in an endless form to simultaneously separate and improve the concentration level of the separation fraction of the target separation system, thereby reducing the consumption of the mobile phase; the various modules in the parametric differential moving bed PDMB operate independently and are coordinated in sequence to achieve the continuous separation of the purification of at least one component as a product and a mixture of components dissolved in a specific uniform feed solution in the form of a new mass transfer equilibrium contact.

[0242] 5. The present invention provides a preferential operating procedure including at least one operation of a startup phase, a steady-state phase, and a termination phase to achieve separation with the disclosed apparatus by coordinating a new mass transfer equilibrium contact method and a differential setting. BRIEF DESCRIPTION OF THE DRAWINGS

[0243] Figure 1 A schematic diagram showing the difference between the operation of the parameter differential moving bed (PDMB) introduced by the differential setting between the solid phase and the mobile phase proposed in the present invention and the sequential operation in the typical chromatography method;

[0244] Figure 2 This is an exploded schematic diagram of the overall structure for closing the mobile phase transmission route proposed by the present invention;

[0245] Figure 3 This is a schematic diagram of the structural decomposition of a single set of processes proposed by the present invention;

[0246] Figure 4 A schematic diagram of the route of the inert gas supply module for the mobile phase liquid flow transmission mechanism proposed by the present invention;

[0247] Figure 5 It is a cross-sectional view and a top view of the structure of the upstream rotary joint module proposed by the present invention;

[0248] Figure 6 It is a cross-sectional view and a top view of the structure of the downstream rotary connection module proposed by the present invention;

[0249] Figure 7 A schematic diagram of the fluidized state of instantaneous mixing or partial stirring of the filler and the feed fluid entering the integral unit proposed by the present invention;

[0250] Figure 8 A schematic diagram of the mixing or partially agitated fluidization state of the filler and the fluid entering the integral unit proposed by the present invention, which is applicable to a single type of resin / adsorbent arranged in multiple layers or multiple resins / adsorbents arranged in multiple layers, wherein the aggregated layers are defined as regions to accommodate a single type of resin / adsorbent, and multiple regions are integrated for arranging multiple resins / adsorbents as an integral unit itself in a single column;

[0251] Fig. 9 The present invention proposes Figure 1 Schematic diagram of the process flow for continuous and simultaneous separation of a single product A and two groups of impurities B1 and B2 by implementing the differential setting into a parametric differential moving bed and combining it with a generalized separation process;

[0252] Fig.10 The combination proposed by the present invention Fig. 9 The generalized separation process shown is a schematic diagram of a single-stage recovery process with continuous and simultaneous isolation of individual products;

[0253] Fig.11 The present invention proposes Figure 1 Schematic diagram of the process flow for the continuous and simultaneous separation of two products A1 and A2 and impurity groups B1, B2 and B3 by differential setting implemented into a parametric differential moving bed and combined with a generalized separation process;

[0254] Fig.12 The combination proposed by the present invention Fig.11 A generalized separation process is shown, schematic diagram of a single-stage recovery process for continuous and simultaneous isolation of at least one product;

[0255] Fig.13 A schematic diagram of a characteristic elution concentration curve of a whole unit test of an example of the 24-region scheme proposed in the present invention;

[0256] Fig.14 The present invention proposes Fig.13 Schematic diagram of the transformation of the characteristic elution concentration profile into a single-stage cycle process;

[0257] Fig.15 The present invention proposes Fig.14 An exploded schematic diagram of a single-stage cycle process, highlighting the single-stage recovery process for separation of a sugar solution arranged in an endless format, and further illustrating multiple separation modules operating simultaneously in parallel;

[0258] Fig.16 Schematic diagram of the basic differences of the three acid-base, pH, and cyclic wave individual components of the adsorption and then elution in terms of hydrodynamics by using the simulated moving bed (SMB) process and the parametric differential moving bed (PDMB) operation through ion exchange column chromatography proposed in the present invention;

[0259] Fig.17 Schematic diagram of the parametric differential separation process proposed in the present invention, wherein a single component is separated from a component mixture by rapid and instantaneous adsorption and desorption of a mass transfer mechanism to achieve a complete separation cycle within a minimum time interval Δt;

[0260] Fig.18 Schematic diagram of the monolithic unit proposed by the present invention as a chromatography column, separating individual components from a mixture of feed stream components by rapid and instantaneous adsorption and elution mass transfer mechanisms, achieving complete separation by illustratively omitting upstream and downstream spin-on modules;

[0261] Fig.19 The present invention proposes Fig.14 Another decomposition diagram of a single-stage cycle process, emphasizing that the batch production throughput requires the upstream and downstream rotary modules to be decomposed into multiple sub-modules, and the functions of multiple sub-modules are integrated into one module, while an example is given to illustrate the use of a single separation module for the separation of sugar solution;

[0262] Fig. 20 Schematic diagram of the mass transfer mechanism for the proposed separation by slow adsorption and elution of a binary system operated in batch mode using a glucose and fructose mixture where the sugar components are dissolved in the eluent to achieve a complete separation cycle through the device within a minimum time interval.

[0263] In the figure: 1 baffle a, 2 baffle b, 3 baffle c, 4 baffle d, 5 baffle f, 6 baffle g, 7 pipeline one, 8 pipeline two, 9 pipeline three, 10 pipeline five, 11 insulating jacket, 12 upstream storage tank module, 13 manifold A, 14 manifold B, 15 upper storage tank, 16 inlet conduit, 17 outlet conduit, 19 circular multi-valve body I, 20 feed area, 21 storage container, 22 liquid outlet conduit, 23 single column, 24 inlet end, 25 mesh filter, 26 manifold C, 27 manifold D, 28 storage, 29 nozzle, 30 pipeline four, 31 vacuum box, 32 liquid collecting conduit, 33 liquid storage, 34 liquid conduit A, 36 interlayer jacket, 37 circular multi-valve body II, 38 transfer container, 39 output conduit, 40 downstream storage tank module, 41 hollow jacket 、42 Manifold F、43 Manifold G、44 Lower storage tank、45 Infusion catheter、46 Drainage tube、48 Outlet pipe、49 Manifold E、50 Aerosol separator、51 Central vacuum pump、52 Water storage tank、53 Liquid catheter、54 Inert gas generator、55 Steel tank container、56 Online gas temperature regulator、57 Manifold L、61 Liquid catheter C、62 Pipeline VI、63 Liquid level sensor、64 Infusion tube、65 Baffle E、66 One-way gas pipeline、67 Manifold H、68 Two-way gas pipeline、69 Manifold J、70 Three-way gas pipeline、71 Manifold K、72 Four-way gas pipeline、73 Five-way gas pipeline、74 Manifold M、75 Six-way gas pipeline、76 Manifold N、79 Manifold O、84 Manifold P、85 Step input、86 Pulse input inlet, 87 impulse input, 88 mass transfer zone, 89 displacement zone, 90 parameter curve, 91 equivalent point, 92 elution curve, 93 feed liquid volume, 94 solid phase volume, 95 integral unit, 97 conduction tube, 98 liquid pipeline a, 99 liquid pipeline b, 100 liquid pipeline c, 101 inlet end, 102 horizontal circular plate a, 103 annular channel a, 104 joint a, 105 liquid conduit D, 106 baffle h, 107 inner rim a, 108 inner top rail a, 109 outer rim a, 110 outer top rail a, 111 inner bottom rail a, 112 outer bottom rail a, 113 pressure activated spring valve a, 114 funnel a, 115 annular fixed chamber a, 116 joint b, 117 servo motor I, 118 brake I, 119 stretch rod a, 120 upper semi-elliptical groove, 121 lower semi-elliptical groove, 122 concentric elliptical tunnel, 123 sphere a, 124 gap a, 125 semicircular groove a, 126 semicircular groove b, 127 semicircular groove c, 128 semicircular groove d, 129 concentric circular tunnel a, 130 concentric circular tunnel b, 131 ring seal, 132 open end, 133 pressure activated spring valve b, 134 horizontal circular plate b, 135 annular channel b, 136 joint c, 137 liquid conduit E, 138 baffle i, 139 inner rim b, 140 inner top rail b, 141 outer rim b, 142 outer top rail b, 143 inner bottom rail b, 144 outer bottom rail b, 145 funnel b, 146 annular fixed chamber b,147 connector d, 148 servo motor II, 149 brake II, 150 stretch rod b, 151 upper semi-arc groove, 152 lower semi-arc groove, 153 concentric tunnel, 154 ball b, 155 gap b, 156 semicircular groove e, 157 semicircular groove f, 158 semicircular groove g, 159 semicircular groove h, 160 concentric circular tunnel c, 161 concentric circular tunnel d, 162 O-type seal, 163 baffle j, 164 circular rigid material, 165 rigid sealing gasket, 166 rigid center rod, 167 circular channel, 1 68 rigid steel wire, 169 circular compartment, 170 side channel, 171 circular opening a, 172 circular opening b, 175 liquid pipeline a, 176 liquid pipeline b, 177 liquid pipeline c, 178 liquid pipeline d, 179 liquid pipeline e, 180 liquid pipeline f, 181 liquid pipeline g, 182 liquid pipeline h, 183 liquid pipeline i, 184 liquid pipeline j, 185 liquid pipeline k, 186 liquid pipeline l, 187 liquid pipeline m, 188 liquid pipeline n, 189 pressure activated check valve a, 190 pressure activated check valve b. DETAILED DESCRIPTION

[0264] The technical solution of this patent is further described in detail below in conjunction with specific implementation methods.

[0265] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0266] like Figure 1 As shown, in a typical chromatography (in the upper left sequential operation): the mass transfer zone 88 indicates that the resin / adsorbent placed in the chromatographic column is saturated and gradually increases in the flow direction of the mobile phase in the introduced feed solution, which contains solute components uniformly dissolved in the predetermined separation system parameters to promote the adsorption of such solute components onto the resin / adsorbent, while pushing the existing mobile phase out of the other end of the column; the displacement zone 89 represents that the fresh adsorbent has not yet been saturated with the feed solution; according to the volume of the input feed solution introduced in the time domain and the options of the three input modes, each mode is named step input 85, pulse input 86 and impulse input 87, because the parameters of the target separation are adjusted to promote the adsorption of dissolved solute components, the same results are produced. In a typical chromatography sequential operation, the feed zone 20 occupies 5-15% of the total volume of the single column 23, and the unused remaining resin / adsorbent in the displacement zone 89, both areas are continuously soaked when in contact with the mobile phase.

[0267] In a typical chromatography (upper right corner in sequential operation): there are three options for entering the mobile phase input mode, each sequential eluent pushes the existing fluid out the other side of the chromatographic column with each desorbed component in turn to produce a so-called characteristic elution curve representing a complete separation cycle. The combined area between the two back-to-back fluids is the parameter curve 90 for the specific target system, which indicates that the predetermined parameters of the mobile phase are gradually changing from the parameters of the feed solution to the parameters of the specific eluent, and the parameter curve 90 starts from the mass transfer zone 88, where all solute components are originally adsorbed in the feed solution. As the separation process progresses in time, all adsorbed components can be selectively eluted from the resin / adsorbent solid phase, and therefore flow with this mobile phase is controlled by each of the specific parameter curves 90. The highest peak of the elution curve 92, shown as a single profile, points to its specific corresponding mobile phase parameter condition, hereinafter referred to as the isovalue point 91, under which the specific adsorbed solute begins to elute from the solid phase and return to the mobile phase. In fact, the equivalent point 91 shows an equilibrium contact state between the solid phase and the mobile phase, and only specific parameter conditions, that is, each adsorbed solute component will not deviate from its bounded site unless the mobile phase around it is conducive to this elution phenomenon. This means that each parameter curve 90 has a specific equivalent point, and the elution curve 92 is consistent, representing that each adsorbed solute component has its own unique equilibrium contact state, and only allows this solute component to elute from the adsorption bonding state back to flow with this mobile phase. This means that before elution, a neutral equilibrium point must be triggered for each component. This fact involves all adsorbed components, that is, despite the presence of fluid dynamics nearby, each adsorbed component can only leave the resin / adsorbent when the surrounding mobile phase conditions exceed its neutral point (equivalent point 91). The elution curve 92 flowing through the displacement zone 89 can be dispersed and widened, which is due to the influence of the column end, axial dispersion and diffusion, and diffusion with the flow direction of the mobile phase, when the elution curve 92 approaches the other end of the chromatographic column, the hydrodynamic effect area of ​​this combination is expanded. As previously mentioned, it is one of the objects of the present disclosure to eliminate displacement zone 89, a problem observed in typical chromatography operations where fluid dynamics results in excessive dilution of the elution peak, thereby increasing cycle time and enhancing inefficient use of the resin / adsorbent solid phase.

[0268] Figure 1 The second part, namely the parameter differential moving bed, utilizes the same combination of mobile phase and solid phase in chromatography through 24 integral units of the example; the present invention utilizes the parameter differential moving bed to realize a new mass transfer equilibrium contact method, integrates the differential setting between the mobile phase and the solid phase, and adopts the predetermined separation system parameters derived from the elution curve to the operating scheme of the device.

[0269] Embodiment 1:

[0270] A parametric differential separation process, such as Figure 1-20As shown, the following steps are included:

[0271] S1: Using a parametric differential moving bed (PDMB) as a generalized separation process, operating the generalized separation process to eliminate the displacement zone in the chromatographic sequential operation;

[0272] Preferably, the generalized separation process is to convert the flow direction of the mobile phase of the chromatographic mass transfer mechanism and the solid phase from a parallel path to a perpendicular path.

[0273] Specifically, a generalized separation process is used to simultaneously introduce each integral unit 95 containing a specific resin / adsorbent filler into a corresponding mobile phase to eliminate the displacement zone in the chromatographic sequential operation;

[0274] Preferably, the integrated unit 95 is used to separate a specific solute mixture containing at least one desired component from at least one other component into a compositionally limited, homogeneous liquid solution mixture containing the solute mixture as a feed solution mobile phase;

[0275] The total amount of adsorbent material installed in each integral unit 95 of the present invention is equivalent to the adsorbent amount of the mass transfer zone (MTZ for short) in chromatography, and the predetermined adsorbent amount in each chromatographic single column 23 is evenly distributed to meet the requirements of the enlarged processing capacity, so that the resin / adsorbent amount installed in the feed deployment area is completely saturated with the feed solution. Compared with chromatography, the MTZ is the resin / adsorbent saturated in the feed solution of about 5% to 10% in the initial part of the resin / adsorbent bed, and this MTZ is transported from one end to the outlet from the other end of the single column 23 by sequentially introducing various types of eluents.

[0276] Further, the specific operation contents of eliminating the displacement zone are: introducing various liquid solutions in a sequential operation, firstly generating an acceptable elution curve of the target separation system by optimizing the same predetermined mobile phase parameters and resin / adsorbent filler as a predetermined combination to be performed in a typical chromatographic separation;

[0277] Among them, various characteristic parameters are selected as mobile phase conditions of homogeneous liquid solutions, including wide-spectrum changes named as pH value, ionic strength, solubility, and polarity, combined with the selected resin / adsorbent filler, which is a combined selection of intermittent operation mode, that is, introducing various liquid solutions in sequential operation.

[0278] Preferably, resin / adsorbent packings are classified into various categories and / or commercially available resin / adsorbent packings are named and used in chromatography, including ion exchange, affinity, reverse phase, normal phase, ligand exchange, granular activated carbon, catalysts and can chemically and selectively interact with dissolved components in the mobile phase feed solution to facilitate continuous separation.

[0279] S2: The mobile phase liquid feed solution is contacted with the solid phase resin / adsorbent filler by a new mass transfer equilibrium contact method, and an acceptable same target separation system is created as an optimization through a feasible predetermined combination between the mobile phase parameters and the resin / adsorbent filler in the currently feasible typical chromatographic separation method, and a characteristic separation curve is initially obtained; so that at least one component contained in the liquid feed solution mixture can be adsorbed onto the resin / adsorbent filler.

[0280] Preferably, the feed solution mobile phase is a liquid solution mixture containing one component and at least one other component for continuous and simultaneous separation of at least one desired component.

[0281] Preferably, the feed solution mobile phase is a solute component of a mixture of oligosaccharides, glucose and fructose, including a percentage composition and a dry solid concentration of components uniformly dissolved in deionized dirt-free water; the eluent and the deionized dirt-free water are used to separate the glucose and fructose components;

[0282] Preferably, the resin / adsorbent is a granular material, specifically, it can be a particle of an alkaline earth metal-based strongly acidic cation exchanger, a calcium-based strongly acidic cation exchanger, and the like.

[0283] Therein, these solute components have a limited component percentage composition and a limited dry solids concentration dissolved in a limited volume of deionized, foul-free eluent water to promote adsorption of at least one component onto the resin / adsorbent.

[0284] Preferably, the dry solid is a pure glucose extract having a dry solid concentration of >35%; further preferably, the dry solid concentration is >51 ppm, and the product is fructose with a purity of 99.99%, and multiple circulating streams with limited characteristics in terms of sugar composition and limited concentration are obtained, wherein the circulating stream contains a solute composition dissolved in a predetermined limited solute percentage component, the eluent solution mixture and the eluent are the same deionized water-free water, and the feed solution mobile phase is included with the multiple circulating streams and the eluent.

[0285] Further, the S2 step includes determining the flux of the mobile phase liquid feed solution and the solid phase amount of the resin / adsorbent for optimal full-strength adsorption capacity, preferably, the solid phase amount is equal to the mass transfer zone for performing the same mass transfer mechanism as the above-mentioned chromatography.

[0286] S3: Separating multiple components contained in a mobile phase liquid feed solution by a new mass transfer equilibrium contact method, so that at least one component contained in the mobile phase liquid feed solution can be adsorbed onto the resin / adsorbent; wherein the mobile phase parameter conditions can be selected as a uniform liquid solution with a wide range of variations, and the materials can be divided into various categories and / or commercially available materials used in chromatography, such as ion exchange, affinity, reverse phase, normal phase, ligand exchange and others that can chemically and selectively interact with dissolved components in the mobile phase to promote separation.

[0287] Preferably, the resin / adsorbent interacts with multiple dissolved components in the mobile phase stream to promote adsorption, and the new mass transfer equilibrium contact method between the two phases is the feed solution.

[0288] Further preferably, the resin / adsorbent interacts with multiple dissolved components in the mobile phase flow, including the following:

[0289] S31: In the first mobile phase zone of the upstream storage tank module 12, at least one of the first mobile phase flows contained in the upper storage tank 15 is a new mass transfer equilibrium contact method that promotes adsorption, that is, the feed solution and the dissolved components are arranged in the first mobile phase zone, i.e., the feed zone; and at least one corresponding lower storage tank 44 arranged in the downstream storage tank module 40 is used to receive and contain the liquid discharged from the first mobile phase and transport it to the last mobile phase zone, i.e., the washing zone;

[0290] S32: In the second mobile phase zone of the upstream storage tank module 12, at least one of the second mobile phase flows contained therein is an eluted adsorbed component using at least one second mobile solution of at least one impurity stripping zone; and at least one corresponding lower storage tank 44 arranged in the downstream storage tank module 40 is used to receive and contain the liquid discharged from the corresponding second mobile phase; wherein at least one component is to increase the corresponding concentration level of the eluted component and return to the designated upper storage tank 15 of at least one impurity stripping zone as a circulating flow to save solution consumption or as at least one by-product for other purposes.

[0291] S33: In the third mobile phase zone of the upstream storage tank module 12, at least one of the third mobile phase flows contained therein is eluted with at least one adsorbed component in at least one third mobile solution of the product recovery zone; and at least one corresponding lower storage tank 44 is arranged in the downstream storage tank module 40 to receive and hold the liquid discharged by the corresponding third mobile phase, and at least one recovered product after elution is to increase the corresponding concentration level of the eluted product and return to the designated upper storage tank 15 of the at least one product recovery zone as a recovery flow to save solution consumption or at least one product for other purposes;

[0292] S34: in the fourth and fifth etc. mobile phase zones of the upstream storage tank module 12, at least one of the fourth and fifth etc. mobile phase flows contained therein is further eluted with at least one regeneration zone and additional zone of at least the fourth and fifth etc. mobile phase solutions in sequence for at least one adsorbed component; and at least one corresponding lower storage tank 44 is arranged in the downstream storage tank module 40 to receive and hold the liquid discharged from the fourth and fifth etc. mobile phases corresponding to at least one component eluted, so as to increase the concentration level of each recovered component, and return to the designated upper storage tank 15 as a circulating flow, corresponding to at least one regeneration zone and additional zone, so as to save solution consumption or at least one by-product for other purposes;

[0293] S35: In the washing area of ​​the upstream storage tank module 12, at least one first mobile phase flow contained in each upper storage tank 15 is transported to clean and wash off the installed resin / adsorbent solid filler; and at least one corresponding lower storage tank 44 arranged in the downstream storage tank module 40 is used to receive and contain the liquid discharged by the first mobile phase, adjust and mix it with the components in the feed solution, and return it to the designated upper storage tank 15 in the feed area as a recovery flow to save solution consumption.

[0294] Further, the content of the step S3 is specifically as follows: dissolving at least one circulating liquid stream having a specific solute composition in a predetermined eluent solution mixture with modified characteristic parameters by a new mass transfer equilibrium contact method to elute a specific adsorbed solute component;

[0295] wherein all of said circulating liquid streams are arranged in sequence and contacted with the resin / adsorbent to separate at least one desired component migrating through the various circulating streams to further gradually separate at least one of the components from at least one of the components through a novel mass transfer equilibrium contact method at each pass through the eluent solution mixture of specific modified characteristic parameters to obtain an acceptable characteristic separation curve, which characteristic separation curve is adopted in a generalized separation process.

[0296] S4: transporting various liquid solutions of at least the second and third mobile phases by the new mass transfer equilibrium contact method; so that at least two components are desorbed one by one.

[0297] Preferably, the liquid solution comprises a predetermined composition which is contacted with the solid phase resin / adsorbent packing.

[0298] The parametric differential moving bed is operated by a differential setting program and a single-stage recovery program, which is a general procedure for a new mass transfer equilibrium contact method between a solid and a mobile phase, and includes the following mixed embodiments: a new mass transfer equilibrium contact method is realized by a parametric differential moving bed, integrating a differential setting program between a mobile phase and a solid phase, and adopting predetermined separation system parameters derived from a characteristic elution curve to an operating scheme of a parametric differential moving bed to separate at least one component from at least one other component, thereby achieving the expected simultaneous separation and concentration, which can be used in large-scale production processes.

[0299] The parametric differential moving bed composed of multiple sub-modules can relatively reduce the weight load of the moving parts arranged in the upstream rotary module and the downstream rotary module, so that the horizontal circular plate 102a and the horizontal circular plate b134 have a larger available surface area to proportionally increase the size of the storage container 21 and the transfer container 38 arranged in the corresponding sub-rotation module; preferably, the holding capacity of the horizontal circular plate 102a and the horizontal circular plate b134 is not limited to the cylindrical shape, but can also be other selected cylindrical shapes to maximize the fitting of the predetermined space so that the transport tanks can be evenly installed at each predetermined position to maintain the temporary capacity of the liquid.

[0300] A1: The new mass transfer equilibrium contact method comprises the following steps:

[0301] i) retaining a predetermined amount of solid phase resin / adsorbent uniformly distributed in a group of a predetermined number of chromatographic single columns 23, similar to a partial fluidized bed, so that the bundled column group acts as an integral unit 95; preferably, each single column 23 in the integral unit 95 retains an equal amount of resin / adsorbent material, such as one of granular ion exchange resin / adsorbent, granular ligand exchange resin / adsorbent, granular reverse phase resin / adsorbent, granular affinity resin / adsorbent, granular normal phase resin / adsorbent, granular activated carbon, granular catalyst and others that can chemically and selectively interact with dissolved components in the mobile phase to promote separation.

[0302] Preferably, the integral unit 95 is used to introduce various liquid solutions in a sequential operation, wherein the predetermined amount of solid phase resin / adsorbent is distributed in the single column 23 as the integral unit 95 itself;

[0303] Preferably, the sum of the resin / adsorbent in the single column 23 is equal to the amount of resin / adsorbent installed as a mass transfer zone in the chromatogram; to fully saturate the pre-fixed feed solution flux.

[0304] ii) during a predetermined first time period, intermittently delivering a predetermined amount of mobile phase liquid material to the integral unit 95 through a predetermined type of liquid distributor to contact the resin / adsorbent, so as to instantaneously promote a uniform new mass transfer equilibrium contact method to adsorb dissolved components onto the lipid / adsorbent or elute adsorbed components from the resin / adsorbent.

[0305] Preferably, the mobile phase liquid material comprises a predetermined composition of various liquid solutions of predetermined composition in at least the second and third mobile phases including the mobile phase liquid feed solution, and at least one circulating liquid stream is organized in sequence.

[0306] Further preferably, the circulating liquid stream is an eluent solution and an eluent capable of eluting a specific adsorbed solute mixture component with a specific solute composition dissolved in a specific modified characteristic parameter, and a pressurized inert gas is subsequently introduced into contact with the resin / adsorbent to promote the desired new mass transfer equilibrium contact method, either to promote adsorption of the dissolved component onto the resin / adsorbent, or to elute the adsorbed component from the resin / adsorbent.

[0307] iii) during a predetermined second time period, after each delivery of the mobile phase liquid material, a wide range of pressurized inert gas is intermittently supplied to the top of the integral unit 95 to maintain sufficient pressure to force the mobile phase liquid to quickly permeate and discharge through the solid phase material to achieve the expected new mass transfer equilibrium contact method between the two phases.

[0308] In addition, step iii) also includes providing a vacuum environment from the bottom of the integral unit 95 to the other side of the installed solid phase material so that the resin / adsorbent material is in a semi-dry state; preferably, this step can be omitted or a low vacuum environment can be used, because the organic mobile phase liquid can be used as part of the eluent, such as adding methanol or acetonitrile to reduce the polarity of pure water in reverse phase chromatography operations, thereby eliminating the problem of organic mobile phase liquid.

[0309] Further, step iii) also includes collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit 95, and repeating steps ii) to iii) until the predetermined sequence of the plurality of liquid solutions is satisfied;

[0310] Preferably, the total time taken for steps ii) to iii) is the minimum time interval Δt.

[0311] A2: The novel mass transfer equilibrium contact method is a method for obtaining a characteristic separation curve for a specific separation system by maintaining the amount of resin / adsorbent solid phase in a semi-dry state as an optimal full-strength adsorption capacity for contact with the volume of a mobile phase liquid feed solution, setting a predetermined amount of resin / adsorbent solid phase in an integral unit 95, and separating a plurality of components contained in at least one first mobile phase flow in a liquid solution containing the components by sequentially contacting the solid phase resin / adsorbent with at least one mobile phase liquid feed solution, such that at least one of the components is adsorbed by the resin / adsorbent;

[0312] wherein the mobile phase liquid feed solution is delivered by a combination of a predetermined type of liquid dispenser and a selected liquid input pattern;

[0313] Preferably, the minimum time interval between the flow and consumption of the first mobile phase is the feed zone;

[0314] Further preferably, a feed solution mobile phase is introduced between two consecutive areas, and the main time interval is defined as a feed zone; then a liquid agent drop of pressurized inert gas is simultaneously and intermittently rapidly passed through at least one integral unit 95 to achieve the expected new mass transfer equilibrium contact method, separating at least one component from at least one other component to obtain a concentrated dry solid concentration and gradually separated glucose and fructose components, wherein the resin / adsorbent is orderly arranged in at least one integral unit 95, and the resin / adsorbent is one of an alkaline earth metal base strong acid cation exchanger, a calcium base strong acid cation exchanger, etc. in the particles.

[0315] Further, the liquid input format delivered by the liquid dispenser includes SI mode and II mode, wherein the duration of the input SI mode along the time domain is that during each time period of the minimum time interval, a predetermined amount of solution with the same mobile phase parameter condition is delivered into the integral unit 95 through a predetermined type of liquid dispenser; in addition, the input II mode is that discrete increments of a predetermined amount of liquid with the mobile phase parameter condition are delivered in the time domain in a sequence of duration within the minimum time interval, and enter the integral unit 95 through a predetermined type of liquid dispenser;

[0316] Preferably, the SI mode option is entered to obtain a characteristic separation curve, delivering the mobile phase by the following procedure:

[0317] A201: intermittently delivering a predetermined amount of at least one of a plurality of first mobile phase flows to the inlet of the integral unit 95 within a predetermined first time period;

[0318] A202: During a predetermined second time period, after each delivery of the first mobile phase, intermittently supplying pressurized inert gas to the top of the integral unit 95 to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit 95;

[0319] Preferably, a vacuum environment is provided on the other side of the integral unit 95 where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state.

[0320] A203: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit 95;

[0321] A204: Define the total time spent in steps A201-A203 as the minimum time interval;

[0322] A205: repeating step A204 until all at least one first mobile phase flow is sequentially delivered and the total cumulative minimum time interval is the first mobile phase zone, and then after a predetermined amount of the first mobile phase flow is intermittently delivered, the resin / adsorbent is further sequentially contacted with at least one second mobile phase flow to achieve a desired new mass transfer equilibrium contact method, so that at least one component is sequentially desorbed separately from the resin / adsorbent;

[0323] Preferably, the second mobile phase flow comprises a liquid eluent of predetermined composition.

[0324] A206: intermittently delivering multiple amounts of at least one predetermined amount of the second mobile phase flow to the inlet of the integral unit 95 during a predetermined first time period;

[0325] A207: During a predetermined second time period, after each delivery of the second mobile phase, intermittently supplying pressurized inert gas to the top of the integral unit 95 to rapidly push the delivered second mobile phase through the resin / adsorbent installed in the integral unit 95;

[0326] Preferably, a vacuum environment is provided on the other side of the integral unit 95 where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state.

[0327] A208: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit 95;

[0328] A209: Define the total time spent in steps A206-A208 as the minimum time interval;

[0329] A210: repeating step A209 until all at least one second mobile phase flow is sequentially delivered and the total cumulative minimum time interval is the second mobile phase zone, and then after a predetermined amount of the second mobile phase flow is intermittently delivered, the resin / adsorbent is further sequentially contacted with at least one third mobile phase flow to achieve a desired new mass transfer equilibrium contact method, so that at least one component is sequentially desorbed separately from the resin / adsorbent;

[0330] Preferably, the third mobile phase flow comprises a liquid eluent of predetermined composition.

[0331] A211: intermittently delivering multiple amounts of at least one predetermined amount of the third mobile phase flow to the inlet of the integral unit 95 during a predetermined first time period;

[0332] A212: During a predetermined second time period, after each delivery of the third mobile phase, intermittently supplying pressurized inert gas to the top of the integral unit 95 to rapidly push the delivered third mobile phase through the resin / adsorbent installed in the integral unit 95;

[0333] Preferably, a vacuum environment is provided on the other side of the integral unit 95 where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state.

[0334] A213: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit 95;

[0335] A214: Define the total time spent in steps A211-A213 as the minimum time interval;

[0336] A215: repeating step A214 until all at least one third mobile phase flow is delivered in sequence and the total cumulative minimum time interval is the third mobile phase zone, if the remaining components are still adsorbed by the resin / adsorbent, repeating step A215 by adding at least one fourth mobile phase flow so that the components can be eluted by a predetermined composition to achieve the expected new mass transfer equilibrium contact method, so that the remaining components are sequentially desorbed from the resin / adsorbent separately, if the remaining components are not adsorbed by the resin / adsorbent, proceeding to step A216;

[0337] A216: intermittently delivering a predetermined amount of at least one of the discharged and collected first mobile phase flows to the inlet of the integral unit 95 during a predetermined first time period in step A203;

[0338] A217: During a predetermined second time period, after each delivery of the first mobile phase, intermittently supplying pressurized inert gas to the top of the integral unit 95 to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit 95;

[0339] Preferably, a vacuum environment is provided on the other side of the integral unit 95 where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state.

[0340] A218: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit 95;

[0341] A219: Define the total time spent in steps A216-A218 as the minimum time interval;

[0342] A220: repeating step A219 until at least one of all first mobile phase streams is delivered in sequence and the total cumulative minimum time interval is the last mobile phase zone;

[0343] A221: Finally, all defined regions are integrated in turn according to the mobile phase parameter conditions in the time domain, thereby obtaining the characteristic separation curve of a specific separation system by inputting the SI mode. The input SI mode is simultaneously and intermittently delivered from a plurality of predetermined input volume quantities of the same mobile phase parameterized tanks set in the same region in the upstream tank module 12 within the minimum time interval in the general procedure, into each corresponding integral unit 95 located in the separation module to perform the new mass transfer equilibrium contact method.

[0344] Alternatively, the new mass transfer equilibrium contact method can be used to transport the mobile phase along the time domain by inputting the option of SI mode, which can be the following [replacement of steps A201-A221]:

[0345] a: contacting the resin / adsorbent with at least one amount of feed liquid mobile phase flow as shown in steps i) to iii) of A1, and defining the total cumulative minimum time interval as the feed zone;

[0346] b: contacting the resin / adsorbent with at least one amount of first circulating mobile phase flow in sequence, each first circulating flow comprising dissolving in a predetermined modified characteristic parameter eluent solution mixture to achieve a desired new mass transfer equilibrium contact method, at least one component is desorbed from the resin / adsorbent in the order shown in steps i) to iii) of A1, and the total cumulative minimum time interval is defined as region 1;

[0347] c: contacting the resin / adsorbent with at least one amount of second circulating mobile phase stream in sequence, each second circulating stream comprising a specific solute composition dissolved in a predetermined modified characteristic parameter eluent mixture to achieve a desired new mass transfer equilibrium contact method, at least one component is desorbed from the resin / adsorbent in the order shown in steps i) to iii) of A1, and the total cumulative minimum time interval is defined as region 2;

[0348] d: repeating step c, and if the remaining components are still adsorbed by the resin / adsorbent, adding a third mobile phase flow of at least a certain amount so that the components can be eluted by a specific solute composition dissolved in a predetermined modified characteristic parameter eluent solution mixture to achieve the expected new mass transfer equilibrium contact method, thereby sequentially desorbing the remaining components from the resin / adsorbent, and defining the total cumulative minimum time interval as region 3;

[0349] e: Repeat step d until the adsorbed components are desorbed in sequence, the corresponding circulating mobile phase flow is acceptable, and the total cumulative minimum time interval corresponds to the matching specific circulating mobile phase, such as area 4, 5, etc., otherwise proceed to step f;

[0350] f: contacting the resin / adsorbent with at least one amount of eluent, and then injecting pressurized inert gas into the inlet of the last integral unit 95 in the order shown in steps i) to iii) of A1 to flush the remaining liquid, the total cumulative minimum time interval being defined as the last zone;

[0351] g: According to the mobile phase parameter conditions in the time domain, all defined areas are combined and integrated in sequence, thereby obtaining the characteristic separation curve of the specific separation system obtained by inputting the SI mode; it is used to eliminate the chromatographic displacement zone and simultaneously separate at least one desired component from at least one other component within each minimum time interval spent.

[0352] Further preferably, the option of input II mode is used to obtain a characteristic separation curve by delivering the mobile phase through the following procedure:

[0353] A251: intermittently delivering a predetermined amount of at least one of the first mobile phase flows to the inlet of the integral unit 95 within a predetermined first time period;

[0354] A252: During a predetermined second time period, after each delivery of the first mobile phase, intermittently supplying pressurized inert gas to the top of the integral unit 95 to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit 95;

[0355] Preferably, a vacuum environment is provided on the other side of the integral unit 95 where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state.

[0356] A253: Collects most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit 95;

[0357] A254: The total time spent in steps A251-A253 is defined as the minimum time interval, also known as the first discrete mobile phase region;

[0358] A255: repeating step A254, by increasing the discrete increments of the mobile phase parameter conditions until all adjusted at least one first mobile phase flow is sequentially delivered with a preset incremental discrete and total cumulative minimum time interval being a plurality of first discrete mobile phase zones, which are sequentially named corresponding to the mobile phase parameter conditions delivered respectively, and then after the parameter conditions of the first mobile phase flow are intermittently delivered in a predetermined amount of discrete increments, the resin / adsorbent is sequentially contacted with at least one second mobile phase flow, and a desired new mass transfer equilibrium contact method is achieved with the discrete incremental parameter conditions, so that at least one component is sequentially desorbed separately from the resin / adsorbent;

[0359] Preferably, the second mobile phase flow comprises a liquid eluent of predetermined composition.

[0360] A256: intermittently delivering multiple amounts of at least one predetermined amount of the second mobile phase flow to the inlet of the integral unit 95 during a predetermined first time period;

[0361] A257: During a predetermined second time period, after each delivery of the second mobile phase, intermittently supplying pressurized inert gas to the top of the integral unit 95 to rapidly push the delivered second mobile phase through the resin / adsorbent installed in the integral unit 95;

[0362] Preferably, a vacuum environment is provided on the other side of the integral unit 95 where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state.

[0363] A258: Collects most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit 95;

[0364] A259: The total time spent in steps A256-A258 is defined as the minimum time interval, also known as the second discrete mobile phase region;

[0365] A260: repeating step A259 by increasing the discrete increments of the mobile phase parameter conditions until all adjusted at least one second mobile phase flow is sequentially delivered with a preset increment discrete and total cumulative minimum time interval being a plurality of second discrete mobile phase zones, which are sequentially named corresponding to the mobile phase parameter conditions delivered respectively, and then after the parameter conditions of the second mobile phase flow are intermittently delivered in a predetermined amount of discrete increments, the resin / adsorbent is sequentially contacted with at least one third mobile phase flow, and a desired new mass transfer equilibrium contact method is achieved with the discrete increment parameter conditions, so that at least one component is sequentially desorbed separately from the resin / adsorbent;

[0366] Preferably, the third mobile phase flow comprises a liquid eluent of predetermined composition.

[0367] A261: intermittently delivering a predetermined amount of at least one of the discharged and collected third mobile phase flows to the inlet of the integral unit 95 within a predetermined first time period;

[0368] A262: during a predetermined second time period, after each delivery of the third mobile phase, intermittently supplying pressurized inert gas to the top of the integral unit 95 so as to rapidly push the delivered third mobile phase through the resin / adsorbent installed in the integral unit 95;

[0369] Preferably, a vacuum environment is provided on the other side of the integral unit 95 where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state.

[0370] A263: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit 95;

[0371] A264: The total time spent in steps A261-A263 is defined as the minimum time interval, also known as the third discrete mobile phase region;

[0372] A265: repeating step A264 by increasing the discrete increments of the mobile phase parameter conditions until all the adjusted at least one third mobile phase flow is discretely carried out by the preset increments delivered in sequence, and the total cumulative minimum time interval is a plurality of third discrete mobile phase zones, which are named in sequence corresponding to the mobile phase parameter conditions delivered respectively, if the remaining components are still adsorbed by the resin / adsorbent, adding at least one fourth mobile phase flow so that the components can be eluted by a predetermined composition, the discrete increments of the mobile phase parameter conditions are adjusted to achieve the expected new mass transfer equilibrium contact method, so that the remaining components are sequentially desorbed from the resin / adsorbent separately, if the remaining components are not adsorbed by the resin / adsorbent, entering step A266;

[0373] A266: intermittently delivering at least one predetermined amount of the first mobile phase flow discharged and collected in step A253 to the inlet of the integral unit 95 within a predetermined first time period;

[0374] A267: During a predetermined second time period, after each delivery of the first mobile phase, intermittently supplying pressurized inert gas to the top of the integral unit 95 to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit 95;

[0375] Preferably, a vacuum environment is provided on the other side of the integral unit 95 where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state.

[0376] A268: Collects most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit 95;

[0377] A269: Define the total time spent in steps A266-A268 as the minimum time interval;

[0378] A270: repeating step A269 until all at least one first mobile phase flow is delivered in sequence and the total cumulative minimum time interval is the last discrete mobile phase zone;

[0379] A271: Finally, all defined regions are integrated in turn according to the mobile phase parameter conditions in the time domain, thereby obtaining the characteristic separation curve of a specific separation system through the input II mode. The input II mode simultaneously and intermittently delivers a plurality of predetermined volumes of "discrete increments" of mobile phase parameter conditions from the upper storage tank 15 set in the same region of the upstream storage tank module 12 to each corresponding integral unit 95 located in the separation module within the minimum time interval specified in the general procedure for executing the new mass transfer equilibrium contact method, so as to execute the new mass transfer equilibrium contact method; wherein the difference increment of the mobile phase condition is predetermined between two specified parameter condition levels, and these parameter conditions are sequentially grouped with each corresponding integral unit 95 in the region.

[0380] Furthermore, the new mass transfer equilibrium contact method can be used to transport the mobile phase along the time domain by inputting the option of the II mode, and can be the following [replacement of steps A251-A271]:

[0381] a1: contacting the resin / adsorbent with at least one feed solution mobile phase flow as shown in steps i) to iii) of A1, and defining the total cumulative minimum time interval as a feed discrete zone, and then repeating this step by increasing the discrete increments of the mobile phase parameter conditions until all at least one feed solution mobile phase flow is adjusted in sequence and the total cumulative minimum time interval is defined as a plurality of feed discrete zones, which are named in sequence and correspond to the corresponding delivery mobile phase parameter conditions;

[0382] b1: The resin / adsorbent is contacted with at least one amount of first circulating mobile phase flow in sequence, each first flow includes a specific solute composition dissolved in a predetermined modified characteristic parameter eluent solution mixture in discrete increments of parameter conditions to achieve an expected new mass transfer equilibrium contact method, at least one component is desorbed from the resin / adsorbent in the order shown in steps i) to iii) in A1, and the total cumulative minimum time interval is defined as discrete zone 1, and then this step is repeated by increasing the discrete increments of the mobile phase parameter conditions until all at least one amount of the first circulating mobile phase flow is adjusted and delivered in sequence. Preset increment dispersion, and the total cumulative minimum time interval is defined as a plurality of discrete regions 1, which are named in sequence and correspond to the corresponding delivery mobile phase parameter conditions; the solute composition is dissolved in a solution with discrete increments of parameters of increasing discrete parameters so as to achieve an expected new mass transfer equilibrium contact method, so that at least one of the components can be sequentially desorbed from the resin / adsorbent.

[0383] c1: contacting the resin / adsorbent with at least one amount of a second circulating mobile phase flow in sequence, each second flow comprising a specific solute composition dissolved in a predetermined modified characteristic parameter eluent solution mixture in discrete increments of parameter conditions to achieve a desired new mass transfer equilibrium contact method, at least one component is desorbed from the resin / adsorbent in the order shown in steps i) to iii) of A1, and the total cumulative minimum time interval is defined as discrete zone 2, and then repeating this step by increasing the discrete increments of the mobile phase parameter conditions until all at least one amount of the second circulating mobile phase flow is adjusted and dispersed in sequentially delivered preset increments, and the total cumulative minimum time interval is defined as a plurality of discrete zones 2, which are named in sequence corresponding to the corresponding delivered mobile phase parameter conditions;

[0384] d1: repeating step c1, if the remaining components are still adsorbed by the resin / adsorbent, adding at least a certain amount of third mobile phase flow, each third flow comprising a specific solute composition dissolved in a predetermined modified characteristic parameter eluent solution mixture in discrete increments of parameter conditions to achieve the desired new mass transfer equilibrium contact method, thereby desorbing the remaining components from the resin / adsorbent in the order shown in steps i) to iii) of A1, and the total cumulative minimum time interval is defined as discrete zone 3, and then repeating this step by increasing the discrete increments of the mobile phase parameter conditions until all at least a certain amount of third circulating mobile phase flow is adjusted and dispersed in a predetermined delivery increment in sequence, and the total cumulative minimum time interval is defined as a plurality of discrete zones 3, which are named in sequence corresponding to the corresponding delivery mobile phase parameter conditions;

[0385] e1: repeating step d1 until the adsorbed components are sequentially desorbed with the corresponding circulating mobile phase flow, and the total cumulative minimum time interval corresponds to the matched specific circulating mobile phase, such as discrete areas 4, 5, etc., and then repeating this step by increasing the discrete increments of the mobile phase parameter conditions until all at least one amount of the corresponding circulating mobile phase flow is adjusted and the preset increment dispersion is delivered in sequence, and the total cumulative minimum time interval is defined as a plurality of discrete areas 4, 5, which are named in sequence and correspond to the corresponding circulating mobile phase parameter conditions;

[0386] f1: contacting the resin / adsorbent with at least one amount of eluent, and then injecting pressurized inert gas into the inlet of the last integral unit 95 in the order shown in steps i) to iii) of A1 to clean and flush the remaining liquid, the total cumulative minimum time interval being defined as the last discrete zone;

[0387] g1: According to the mobile phase parameter conditions in the time domain, all defined areas are combined and integrated in sequence, thereby obtaining the characteristic separation curve of a specific separation system obtained by input II mode.

[0388] Fig. 9 The elution curve obtained by the above-mentioned new mass transfer equilibrium contact method is sequentially decomposed into the partial time required for the input of the solution of the corresponding predetermined mobile phase parameter (operating condition) in the area, including the feed solution in #1 as 20 zones, the impurity stripping #2 solution as 21 zones, the product A recovery #3 solution as 22 zones, the regeneration #4 solution as 23 zones, and the recovery of the #1 solution from the feed zone as 24 zones for washing. Each partial time is divided by the minimum time interval to obtain the range of the overall unit 95 set for the area; then the total input volume of the liquid is divided by the number of units set for the area to obtain the partial volume required for each unit in the corresponding area; then, the partial volume is divided by a pre-selected number to further distinguish multiple liquid doses for the general procedure of the new mass transfer equilibrium contact method, and again depends on the design preference of the specific target system. The resin / adsorbent is further divided by a preselected number, and all integral units 95 having corresponding mobile phase parameters are sequentially assigned as ranges of respective regions, and all regions are assigned as infinite formats; predetermined volumes of solutions of each predetermined mobile phase parameter are prepared and stored in corresponding tanks of the upstream tank module 12 for distribution of such liquids throughout the disclosed apparatus to achieve the desired separation.

[0389] Specific: such as Fig. 9The first mode shown in the upper part is isocratic elution, input SI, and continuous 5-region step input 85 in the time domain corresponds to #1, #2, #3, #4, and #5 as five different types of mobile phase parameters (operating conditions), and generates the interaction between the solute dissolved in the mobile phase and the resin / adsorbent installed in the integral unit 95. As in the aforementioned new mass transfer equilibrium contact method, the step input 85 is used to explain the operating conditions in the time domain, and a small amount of liquid phase is intermittently transmitted and quickly penetrates the entire installed resin / adsorbent set in the integral unit 95. The liquid input type explained in the time domain is actually Figure 1 A form of pulse input 86 is shown, and the duration of this liquid input in the time domain is reduced to as small as possible, corresponding to the defined minimum time interval Δt. Therefore, the definition of the liquid input amount of the present invention is preferably described as a step input 85 in the mobile phase parameters (operating conditions), but with a pulse input 86 in the time domain, which is defined as input SI below, to distinguish it from a typical chromatographic operation.

[0390] Fig. 9The second input mode shown in the lower half is called discrete isocratic elution, input II, a set of different mobile phases are input between two main mobile phase parameters (operating conditions), and the discrete increments of the mobile phase parameters are very small. In the new mass transfer equilibrium contact method, the small increment of the step input 85 in the mobile phase parameter is defined as the smallest possible change along the imaginary inclined point line, and is performed in a portion of each defined minimum time interval Δt during the new mass transfer equilibrium contact method described above, meaning that the pulse input represents both the operating conditions and the duration. The duration of the small increase in the mobile phase parameter can be equal to one or more minimum time intervals, and the slope of this imaginary point line depends entirely on the design preference of the target separation system. Through input II, a typical gradient mobile phase elution in a high pressure liquid chromatography (HPLC) process is simulated to maximize the elution of the current dissolved solute group and minimize the elution of the subsequent solute group to avoid so-called co-elution because the elution isovalue points of two adjacent dissolved solute groups are close to each other. Through the above-mentioned elution isovalue teaching, the present invention utilizes the same mobile phase and solid phase combination used in chromatography to separate through the new mass transfer equilibrium contact method to eliminate the displacement zone and dead volume to achieve the purpose of scale-up production. By precisely controlling various mobile phase parameters to intermittently and simultaneously contact the solid phase to achieve mass transfer equilibrium, ultimately, through future descriptions containing new mass transfer equilibrium contact methods and differential settings between the two phases and customized single-stage operation procedures, implemented on PDMB, the maximum separation efficiency is obtained within the minimum time interval Δt. The integration of the mobile phase volume and its corresponding minimum time interval Δt for the selected input SI or input II is equivalent to a complete separation cycle. Therefore, the above figure of the above device indicates that input SI and input II are distinguished from chromatography, but the mass transfer efficiency is higher. Generally speaking, input II is not required unless better separation is required.

[0391] By starting with mobile phase #1 (feed parameters) and going through the elution process flow in sequence from #2 to #4, the schematic elution curve for input SI is plotted with three peaks in the relationship between solute concentration (left Y axis) and time domain and mobile phase parameters (right Y axis) and time domain: The first step is to load feed #1 onto the fresh resin / adsorbent carried out in the feed zone 20 to obtain the ultimate adsorption efficiency; this means taking the shortest possible time to obtain the maximum throughput of the predetermined feed volume. All operating conditions for each subsequent eluent are predetermined based on the teachings of the previous isopoint belief. The mobile phase parameter conditions are predetermined, and the #2 condition is preset before the isopoint of the desired product A, so only impurity B1 can be eluted, which includes the impurity stripping step carried out in the impurity stripping zone 21. Then, the #3 mobile phase condition only elutes the desired product A, which covers the product recovery step carried out in the product recovery zone 22, and retains the impurity group B2 in the solid phase. The #4 condition is the elution that covers the impurity B2 in the input, and the regeneration step is carried out in the regeneration zone 23. Finally, a cleaning step is performed in the sanitizing / cleaning zone 24 by recovering the #1 mobile phase collected from the loading zone 20 to prepare for the re-feeding of the resin / adsorbent.

[0392] The final adsorption efficiency is obtained by starting the feed step with input II and performing the process in the feed zone 20 with mobile phase #1. Starting with mobile phase parameters #1 and ending with #2, an impurity stripping step is performed in the impurity stripping zone 21 by input II to maximize the elution of the first impurity group B1 to avoid co-elution with product A. Starting with #2 and then ending with mobile phase parameters #3, the product recovery step is performed in the product recovery zone 22 by input II to maximize the elution of product A to avoid co-elution with the second impurity group B2. Generally, an increment of the mobile phase parameters with a minimum interval of Δt is sufficient. Once product A is eluted, a regeneration step is performed in the regeneration zone 23 by input SI #4 mobile phase to completely strip the second impurity group B2 from the solid phase. Finally, the #1 mobile phase is recovered from the loading zone 20 and a disinfection / washing step is performed in the washing zone 24 by input SI to prepare for the resin / adsorbent to be fed again.

[0393] Fig. 9 The elution curve shown is generated by the new mass transfer equilibrium contact method, first consuming the saturation amount of resin / adsorbent set in a typical chromatographic column, and the starting point of this curve elution time, meaning Figure 1The displacement zone 89 described in the above is completely eliminated, and there is no dead volume in the fluid delivery system. According to the nature of the new mass transfer equilibrium contact method, the expected mass transfer phenomenon has been performed by rapidly flowing through the resin / adsorbent installed in a single column by inputting a pressurized inert gas at the top and connecting to the vacuum environment at the bottom, because the delivered liquid is rapidly processed and discharged through the resin / adsorbent. All kinds of processed liquid mixtures are collected from the bottom of this integrated unit 95, and the concentration and composition of each liquid mixture represents a complete separation cycle.

[0394] A3: The parameter differential moving bed includes an upstream storage tank module 12, an upstream rotary module, a separation module, a downstream rotary module, a downstream storage tank module 40 and an inert gas supply module. The above modules are connected in sequence but operate independently as a whole. The structure of the PDMB here is basically the same as the applicant's previous patent 'Device for improving the simulated moving bed for continuous separation of glucose and fructose'; the upstream storage tank module 12, the upstream rotary module, the separation module, the downstream rotary module, the downstream storage tank module 40 and the inert gas supply module are operated in parallel; in the general separation process, multiple separation modules can be set to operate in parallel and simultaneously during steady-state operation within each time interval spent; by sequentially transporting liquid from top to bottom, the specified throughput of multiple separation modules operating in parallel in the device can be met.

[0395] The upstream rotary joint module serves as a bridge between the upstream storage tank module 12 and the separation module, so that when the rotary joint is in a stationary state, it can receive and retain the liquid in an orderly manner, and at the same time advance a rotation step. Through rotation, positioning and sealing mechanisms, various liquid flows such as multiple recovery mixtures and feed solutions, and at least one eluent in the upper storage tanks 15 arranged in the corresponding area in a specified order are orderly transported from each upper storage tank 15 in the upstream storage tank module 12 to the designated inlet of the corresponding integral unit 95 of the separation module in the selected input SI mode and input II mode.

[0396] The downstream rotary joint module is a bridge between the bottom of the separation module and the downstream storage tank module 40; it is used to receive and retain liquid in an orderly manner, and at the same time advance a rotation step. When the rotary joint module is in a stationary state, various liquid flows are simultaneously and orderly transported from the various bottoms of the separation module to the corresponding lower storage tank 44 in the downstream storage tank module 40 through rotation, positioning and sealing mechanisms.

[0397] The inert gas supply module is a transmission mechanism submodule for mobile phase liquid flow and integrated with the separation module, and the transmission mechanism submodule is incorporated with the above-mentioned other modules; in each time interval during the steady-state operation duration, all kinds of liquid solutions simultaneously distribute the entire available liquid solution, and all available liquid solutions from each upper storage tank 15 in the upstream storage tank module 12 are distributed to each integral unit 95 in the separation module through each storage container 21 in the upstream rotary module to perform a new mass transfer equilibrium contact method. The collected liquid discharged from each temporary liquid reservoir 33 is transferred to each lower storage tank 44 in the downstream storage tank module 40 through the transfer container 38 in the downstream rotary module, and circulated back to the upstream storage tank module 12 in turn through the downstream storage tank module 40 to obtain a closed-loop operation mode of the new mass transfer equilibrium contact method. This organized liquid transfer operation is carried out by a parameter differential moving bed combined with a large-scale pressurized inert gas in the inert gas supply module to achieve repeated separation cycles of the target system.

[0398] Furthermore, the parametric differential moving bed utilizes a new mass transfer equilibrium contact method to obtain a characteristic elution curve between a selected SI mode and a selected II mode through a selected combination of a mobile phase and a solid phase resin / adsorbent;

[0399] Preferably, the characteristic elution curve is used to establish a differential setting procedure, and the specific steps are: adopting the general procedure of the new mass transfer equilibrium contact method, implementing the differential setting procedure to the parameter differential moving bed through a single-stage recovery procedure, and then carrying out the new mass transfer equilibrium contact method together with the mobile phase liquid flow transmission mechanism;

[0400] Further preferably, a parametric differential moving bed is used to separate a component and at least one other component from a feed solution mixture containing one component and at least one other component dissolved in an eluent, wherein at least one other component in the composition is mixed in the eluent in contact with a solid phase particle resin / adsorbent, and through adsorption and sequential contact with various adjusted eluents, each component of the sequentially eluted composition has a different isopoint equilibrium state, wherein the isopoint is an equilibrium state in which a specific adsorbed component begins to desorb from the solid phase filler, so that desorption of a single component occurs sequentially to a specific concentrated product component of at least one product or another enriched component of at least one by-product, as well as to multiple recovery mixtures; further preferably, the recovery mixture includes a specific composition of components dissolved in the discharged solution and the eluent used for recovery.

[0401] Preferably, the solid phase granular resin / adsorbent is one of granular ion exchange resin / adsorbent, granular reverse phase resin / adsorbent, granular affinity resin / adsorbent, granular normal phase resin / adsorbent, granular activated carbon and granular catalyst, and other materials that can chemically and selectively interact with dissolved components in the mobile phase to promote separation, etc.;

[0402] Among them, the upstream storage tank module 12 includes a heat medium circulation insulating jacket 11, and a plurality of upper storage tanks 15 of different sizes arranged inside the insulating jacket 11, and all the upper storage tanks 15 are arranged into an organized array in a selected pattern; preferably, in this embodiment, there are 24 upper storage tanks 15; so as to keep the entire set of upper storage tanks 15 within a selected temperature range.

[0403] Furthermore, the multiple upper storage tanks 15 include at least one feed tank and at least one eluent tank, wherein the feed tank includes a portion of the feed solution that is evenly distributed from the total feed solution throughput, and all feed tanks are integrated into a feed zone; the eluent tank includes an eluent and a modified eluent composition, and the eluent composition includes selected discrete increments of parameter conditions for respective eluent components; an adjusted mobile phase eluent having a discrete isopoint equilibrium differential state under the parameter conditions is orderly contacted with the resin / adsorbent installed in the integral unit 95 to cause a single adsorbed component having a corresponding discrete isopoint equilibrium differential state in contact with the surrounding to be eluted in sequence, thereby integrating the corresponding adjusted eluents in all the integral units 95, wherein the adjusted eluent is a specific composition of a plurality of recovered mixtures having a component dissolved in the eluent discharged for recovery, and is orderly contained in each of the multiple upper storage tanks 15 as respective elution zones.

[0404] Preferably, the eluent is adjusted to contact with the particulate reverse phase resin / adsorbent, including a deionized pure water eluent; the eluent composition is adjusted to have discrete increments of parameter conditions for the respective compositions of the eluents, so that the resulting individual adsorbed components have isopoint equilibrium states with discrete differences under the parameter conditions, and the eluent is mixed with an organic solvent of lower polarity to reduce the polarity of the adjusted eluent;

[0405] Preferably, the conditioning eluent is contacted with the particulate normal phase resin / adsorbent, including a non-polar solvent eluent, and the eluent is mixed with a more polar organic solvent to increase the polarity of the conditioning eluent, thereby increasing the solubility of the adsorbed components to desorb and elute back into the surrounding conditioning mobile phase eluent.

[0406] Further preferably, when the eluent is mixed with the organic solvent with lower polarity, the volume percentage of the selected organic solvent is increased by 5% to 95% by volume.

[0407] Preferably, the modified eluent composition comprises an eluent selected under discrete increasing parameter conditions to produce a single adsorbed component having a discrete isopoint equilibrium state under the parameter conditions, the difference being that the eluent is mixed with a more polar solvent to increase the polarity of the modified eluent, thereby increasing the solubility of the adsorbed component to desorb and elute with the surrounding modified eluent. The eluent composition is contacted with a solid phase particulate resin / adsorbent, the solid phase particulate resin / adsorbent is a particulate normal phase resin / adsorbent, and the eluent is a non-polar solvent.

[0408] Further preferably, at least one different modified eluent is arranged in order between multiple modified eluents, each eluent has a composition preset before the isopoint of the component, and the isopoint eluent can sequentially desorb at least one of the first other components and does not elute the adsorbed component and the remaining at least one other component, and multiple recovery mixtures have specific compositions dissolved in the eluent discharged for recovery, and are orderly contained in multiple upper storage tanks 15 as at least one first elution zone.

[0409] Preferably, at least one modified eluent is arranged in an orderly manner with at least one incremental parameter condition, each having a preset isopoint composition; the minimum isopoint of a component is the minimum isopoint of the component, the component can desorb a portion of the component and cannot elute the remaining portion of at least one other component adsorbed; and such multiple recovery mixtures are orderly contained in each upper storage tank 15 as at least one component recovery zone and named as at least one product recovery zone.

[0410] Preferably, at least one modified eluent is arranged in an orderly manner with at least one incremental parameter condition, each eluent has a preset isopoint composition, which is higher than the isopoint of one component and the isopoint of all other components, and can desorb at least one remaining another component; this orderly arrangement of multiple recovery mixtures is orderly contained in each upper storage tank 15 as at least a second elution zone and is named a regeneration zone.

[0411] Preferably, at least one eluent tank containing the eluent itself is used to wash off the resin / adsorbent in the corresponding integral unit 95 that is ready to be contacted with the feed liquid of the feed zone as a wash zone.

[0412] Further, each of the upper storage tanks 15 includes at least a portion of the feed solution, an eluent having a specific recovery mixture with specific components, and an eluent for simultaneous transmission to the separation module so as to sequentially elute the adsorbed components, the flow and the discharged liquid solution, and is expressed in a selection format between SI mode and II mode, thereby obtaining a characteristic elution curve of a specific target separation system.

[0413] Furthermore, the top surface of the upper storage tank 15 is provided with an inlet duct 16 which penetrates the outer wall of the insulating jacket 11 and extends upward, and the bottom end of the inlet duct 16 is provided with a baffle a1, and the inlet duct 16 is used to receive liquid when the baffle a1 is opened; the bottom surface of the upper storage tank 15 is provided with an outlet duct 17 which penetrates the outer wall of the insulating jacket 11 and extends downward, and the top end of the outlet duct 17 is provided with a baffle b2, and the circumferential outer wall of the outlet duct 17 is provided with a pressure-activated check valve a189, and the outlet duct 17 is used to discharge all the stored liquid when the baffle b2 is opened, and the closing setting of the pressure-activated check valve a189 is used to accommodate the received liquid or discharge the liquid into the next module under pressure.

[0414] Preferably, an inert gas with a wide pressure range is supplied around the top and bottom of each upper storage tank 15 through corresponding air pipes as a driving force for opening or closing the baffle a1 or baffle b2. When the baffle b2 is closed, the received liquid is stored or when the baffle b2 is opened and the baffle a1 is closed, the stored liquid is discharged into the next module.

[0415] Furthermore, the insulating jacket 11 includes a manifold A13 for connecting the warm water inlet and a manifold B14 for connecting the warm water outlet; the upper storage tanks 15 are arranged in the warm water circulation insulating jacket 11, so that all the upper storage tanks 15 can be maintained within the selected temperature range.

[0416] Among them, the upstream rotary connection module includes a circular multi-valve body Ⅰ19 controlled and driven by a driving member Ⅰ, which is a rotating, positioning and sealing mechanism; the circular multi-valve body Ⅰ19 [especially the horizontal circular plate a102] driven by the stretching rod a119 rotates forward or stops rotating intermittently at equal angles during operation around a selected direction, and the circular multi-valve body Ⅰ19 is used as a part of the upstream rotary connection module for bridging and simultaneously transporting various liquids.

[0417] Preferably, the driving member I is electrically connected to the control module, and is a servo motor I 117 and a brake I 118;

[0418] Furthermore, the circular multi-valve body I19 includes a horizontal circular plate a102, a stretching rod a119 fixedly connected to the inner wall of the horizontal circular plate a102, a plurality of storage containers 21 arranged in a circular array on the top surface of the horizontal circular plate a102, and a plurality of liquid outlet conduits 22 arranged in a circular array on the bottom surface of the horizontal circular plate a102, and the bottom end of the stretching rod a119 is connected to the output end of the driving member I through a coupling; the top opening of the storage container 21 is used to receive liquid transferred from a specific upper storage tank 15 of the upper upstream storage tank module 12, and the liquid outlet conduit 22 is provided for accurately transferring the liquid to the next module.

[0419] Preferably, the top surface of the storage container 21 is fixedly connected with the inlet port 101, and the number of the storage containers 21 is the same as the number of the outlet conduits 17, and they are connected one-to-one through the conduits;

[0420] Preferably, a pressure-activated spring valve a113 is provided on the outer wall of the top end of the liquid outlet conduit 22, which is used to control the amount of liquid received by the storage.

[0421] Furthermore, the top surface of the horizontal circular plate a102 is fixedly connected to an annular channel a103 with a 'U'-shaped cross-section, and the storage container 21 is arranged inside the annular channel a103 to cover multiple components; the top surface of the annular channel a103 is fixedly connected to a connector a104, and the connector a104 is connected to the outlet conduit 17 at the bottom of the upper storage tank 15, and the output end of the connector a104 is connected to the top of the inlet end 101 through the liquid conduit D105 after passing through the upper surface of the annular channel a103, and the liquid conduit D105 is arranged inside the annular channel a103; so as to receive the liquid output from the upper storage tank 15 into the storage container 21.

[0422] Preferably, a baffle h106 is fixedly connected to the inner wall of the storage container 21 near the top, so that the liquid entering the storage container 21 can slide smoothly along the inner wall like an umbrella.

[0423] Further preferably, the circumferential inner wall of the annular channel a103 is fixedly connected with an inner top railing a108 and an inner bottom railing a111 which match each other up and down, and the inner bottom railing a111 is fixedly connected to the top surface of the horizontal circular plate a102; the circumferential outer wall of the annular channel a103 is fixedly connected with an outer top railing a110 and an outer bottom railing a112 which match each other up and down, and the outer bottom railing a112 is fixedly connected to the top surface of the horizontal circular plate a102; so that the annular channel a103 can be connected and fixed to the horizontal circular plate a102.

[0424] Among them, the top surface of the inner top railing a108 is fixedly connected to the inner rim a107, and the top surface of the outer top railing a110 is fixedly connected to the outer rim a109; the matching inner bottom railing a111 and the matching outer bottom railing a112, the inner bottom railing a111 and the outer bottom railing a112 both have a flat and smooth surface to be tightly fixed to the top surface of the horizontal circular plate a102.

[0425] The inner walls of the concentric cavities formed between the inner top rail a108 and the inner bottom rail a111 and between the outer top rail a110 and the outer bottom rail a112 are filled with a plurality of spheres a123; the spheres a123 are arranged inside the concentric cavities with diameters slightly larger than the vertical heights thereof, thereby forming a small enough gap to control the free movement of the horizontal circular plate a102 through the centrally mounted driving member I;

[0426] In addition, an upper semi-elliptical groove 120 is provided at the center of the bottom surface of the outer top railing a110, which matches the lower semi-elliptical groove 121 provided at the center of the top surface of the outer bottom railing a112, and the upper semi-elliptical groove 120 and the lower semi-elliptical groove 121 are buckled to form the same concentric elliptical tunnel 122, and the diameter of the ball a123 is slightly larger than the vertical height of the concentric elliptical tunnel 122, thereby forming a gap a124; so that the horizontal circular plate a102 can be driven to move freely by the servo motor I117.

[0427] The inner top railing a108 and the outer top railing a110 are provided with semicircular grooves a125 and c127 on both sides of the bottom surface, the inner bottom railing a111 and the outer bottom railing a112 are provided with semicircular grooves b126 and d128 on both sides of the top surface, and concentric circular tunnels a129 and concentric circular tunnels a129 are formed between the inner top railing a108 and the inner bottom railing a111, and between the outer top railing a110 and the outer bottom railing a112. The inner walls of the circular tunnel b130, the concentric circular tunnel a129 and the concentric circular tunnel b130 are respectively filled with ring-shaped seals 131; the diameter of the ring-shaped seal 131 is just large enough to seal the gap of the concentric circular tunnel b130, and the arrangement of the ball a123, the ring-shaped seal 131, etc. is used to provide sufficient frictionless rotation and positioning, as well as a sealing mechanism for the horizontal circular plate a102, and to provide minimal pressurized inert gas leakage and sealing mechanism for such rotation and positioning.

[0428] Further preferably, the bottom surface of the horizontal circular plate a102 is fixedly connected with an annular fixed chamber a115 having the same structure as the annular channel a103. Preferably, the gap between the annular fixed chamber a115 and the horizontal circular plate a102 is infinitely small, which can minimize the leakage of the pressurized inert gas and ensure the intermittent rotation of the horizontal circular plate a102. The bottom inner wall of the annular fixed chamber a115 is fixedly connected with wide open-top funnels a114 having the same number and corresponding upper and lower positions as the storage container 21; the bottom outer wall of the annular fixed chamber a115 is fixedly connected with a joint b116, and the joint b116 is connected to the outlet of the funnel a114, and the funnel a114 is connected to the liquid outlet conduit 22, and a liquid conduit C61 is provided between the joint b116 and the storage 28; it is used to receive the liquid in the storage container 21 and transport it to the next module.

[0429] By opening the baffle c3 with a medium range of pressurized inert gas, all the liquid in the storage container 21 enters the stationary wide open-top funnel a114 below through the liquid outlet conduit 22, and is evenly arranged at the corresponding position of the liquid conduit D105 as a transit transport to accurately handle all the liquid transferred between the two. The transported liquid is further connected to the liquid conduit C61 through the joint b116 arranged outside the annular fixed chamber a115, enters the reservoir 28 and then enters each integral unit 95 to perform the expected mass transfer equilibrium contact between the mobile phase and the solid phase, thereby bridging the upstream rotary module to wait for another round of liquid throughput.

[0430] As a supplement, the intermittent rotation of the horizontal circular plate a102 can be controlled by a hydraulic actuator, a pneumatic actuator, an electric actuator and an optical sensor system.

[0431] When the horizontal circular plate a102 is in a stationary state, the upstream rotary module provides a pressurized inert gas delivery mechanism for the mobile phase liquid flow to discharge the delivered liquid into the designated top of the separation module and wait for another round of liquid delivery throughput.

[0432] The separation module comprises a plurality of integral units 95 disposed inside the insulating heat medium circulation jacket 36 and a plurality of single columns 23 disposed in a predetermined number in an orderly manner inside the integral units 95, so that the plurality of integral units 95 are maintained within a selected temperature range.

[0433] Preferably, the top surface of the single column 23 is provided with an inlet end 24, the bottom surface of the single column 23 is provided with an outlet end, and a mesh filter 25 is provided inside the outlet end to prevent discharge of an equal amount of resin / adsorbent material.

[0434] Further preferably, the single column 23 retains a determined amount of resin / adsorbent solid material, corresponding to the amount of resin / adsorbent installed as a mass transfer zone in the chromatogram, to fully saturate a predetermined feed solution throughput.

[0435] Alternatively, the single column 23 includes a plurality of stacking rings, the bottom end of the stacking ring is provided with a mesh filter 25 for preventing the granular resin / adsorbent material from being discharged, and an independent space is left between two adjacent stacking rings, and an inlet end 24 is opened at the top of the stacking ring; the interior of the single column 23 is subdivided into a plurality of thin-layer spaces, and the bottom of the thin-layer space is supported by the mesh filter 25 and equipped with a circular rigid material 164, the mesh filter 25 serves as a separator between two adjacent circular rigid materials 164 above and below, and provides better liquid penetration capacity in the entire overall unit 95, reduces pressure drop, and adapts to specific target separation requirements.

[0436] Preferably, the resin / adsorbent content in each stacked ring is different; the stacked rings retain a determined amount of resin / adsorbent corresponding to the installed mass transfer zone in the chromatograph to fully saturate the predetermined feed solution throughput.

[0437] Further preferably, the resin / adsorbent filler in the stacking ring is a combination of anion exchanger, cation exchanger, reverse phase, normal phase, activated carbon and catalyst; it can react chemically with the mobile phase and has adsorption and desorption capabilities.

[0438] wherein the cation exchanger is a calcium-based strongly acidic cation exchanger; to achieve a raffinate of pure glucose with a limited dry solid concentration exceeding 35%, to achieve 99.99% fructose purity as a product with a limited dry solid concentration exceeding 51%, and to obtain multiple circulating streams each having a sugar composition with limited characteristics and a limited dry solid concentration.

[0439] Furthermore, a temporary transition storage 28 is provided on the top surface of the integral unit 95, and the top end of the storage 28 passes through the top surface of the interlayer sleeve 36 and extends upward; a temporary transfer storage 28 is provided on the top of each integral unit 95 to receive a specific liquid transported from the corresponding upper storage tank 15 in the upstream storage tank module 12.

[0440] Preferably, a baffle c3 for controlling the distribution of liquid and inert gas is provided at the top of the storage tank 28, and the baffle c3 includes a circular rigid material 164 arranged on the inner wall of the circumference of the rigid sealing gasket 165 for top and bottom sealing, and a rigid steel wire 168 is fixedly connected to the top surface of the baffle c3, and a circular channel 167 is fixedly connected to the outer wall of the rigid steel wire 168, and a rigid center rod 166 is provided on the inner wall of the baffle c3, and the top end of the rigid center rod 166 is inserted into the interior of the circular channel 167; it is used to keep the baffle c3 in an upright position in the circular channel 167 and be confined in a circular compartment 169 of the liquid conduit aligned with the inner wall.

[0441] Further preferably, the inner wall of the reservoir 28 is provided with a circular compartment 169, which includes a circular opening a171 and a circular opening b172 opened on its outer wall, and a side channel 170; the circular compartment 169 is used for when the pressurized inert gas is applied from the bottom, the baffle c3 can move freely upward to keep blocking the liquid from passing through, or when the baffle c3 switches to a downward position to allow the fluid to quickly pass through the side channel 170 and the circular opening a171, the pressurized inert gas supplied from the bottom is closed, and the pressurized inert gas supplied from the top is opened, which is a mechanism for coordinating the mobile phase liquid transmission with a wide range of pressurized inert gases.

[0442] Preferably, a baffle d4 is provided between the bottom end of the reservoir 28 and the top end of the nozzle 29 fixedly connected to the top inner wall of the integral unit 95, and a baffle j163 is fixedly connected to the bottom surface of the baffle d4; the liquid entering the integral unit 95 can smoothly slide down along the inner wall like an umbrella and hit the inner wall of the container, and quickly slide downward to partially lift upward and penetrate into the resin / adsorbent particles suspended in the liquid during upward stirring, which can greatly reduce the time required for mass transfer between the two phases.

[0443] The liquid distributor is a spray head 29, which wets a part of the installed resin / adsorbent area by intermittently transmitting and sprinkling a predetermined volume of fluid in a short time, so as to achieve a new mass transfer equilibrium contact method between the expected two phases.

[0444] Further preferably, a pipe three 9 is provided on the outer wall of the storage tank 28 between the baffle c3 and the baffle d4; the pipe three 9 is used to pressurize and dry the inert gas over a large area to intermittently and simultaneously drip out part of the received liquid from the storage tank 28 so that it can quickly wet the top of the resin / adsorption bed and pass through according to a predetermined liquid input format to execute the expected new mass transfer equilibrium contact method.

[0445] Furthermore, the interior of the interlayer sleeve 36 is provided with two or more vertically mounted partitions for confining each integral unit 95 in a predetermined compartment, so that the warm water flows alternately through all the closed integral unit 95 compartments in sequence and then flows out, so that all the integral units 95 are maintained within a predetermined temperature range.

[0446] Furthermore, the interlayer sleeve 36 includes a manifold C26 for connecting the warm water inlet and a manifold D27 for connecting the warm water outlet; multiple integral units 95 are arranged in the warm water circulation insulating interlayer sleeve 36, so that all the integral units can be maintained within the selected temperature range.

[0447] Furthermore, the bottom surface of the integral unit 95 is connected to a vacuum box 31, and a side surface of the vacuum box 31 is provided with an outlet pipe 48 for discharging wet inert gas; the bottom of each integral unit 95 is exposed to a closed vacuum environment so that the resin / adsorbent material is in a semi-dry state.

[0448] Preferably, a funnel-shaped liquid collecting conduit 32 is provided on the bottom surface of the integral unit 95, and a baffle e65 is provided on the bottom inner wall of the liquid collecting conduit 32;

[0449] Preferably, a manifold E49 for supplying low-range pressurized inert gas when the vacuum box 31 is closed is provided on one side of the vacuum box 31. Preferably, the manifold E49 is provided below the closed vacuum environment and extends downward through the outer wall of the interlayer sleeve 36. The top of the liquid reservoir 33 is widely open, and wet inert gas [i.e., liquid-enriched mist inert gas in the mobile phase] is extracted through the manifold E49 via the outlet pipe 48 to keep the resin in a semi-dry state, and the discharged liquid is received through the bottom funnel-shaped liquid collecting conduit 32, and introduced into each temporary liquid reservoir 33 below through the baffle e65.

[0450] Preferably, a temporary liquid reservoir 33 is provided inside the vacuum box 31 for assisting in receiving the discharge of the dripping amount of liquid. Preferably, the top of the liquid reservoir 33 is open; the liquid in the integral unit 95 is discharged into the liquid reservoir 33 through the funnel-shaped liquid collecting conduit 32, so as to collect the liquid from various areas and redistribute it for further application.

[0451] The fluid transported in this link quickly penetrates the rest of the bed to complete the expected mass transfer equilibrium contact, wherein the mobile phase is quickly processed and discharged, which means that the retained solid phase returns to its initial semi-dry state throughout the bed. Therefore, the mass transfer mechanism can be distinguished from chromatography, and the new mass transfer equilibrium contact method is repeated continuously until the liquid stored in the reservoir 28 is exhausted within a predetermined minimum time interval Δt. The minimum time interval required to complete the new mass transfer equilibrium contact method is the mechanical limitation for rapid movement, transportation and discharge.

[0452] Further preferably, a liquid conduit A34 is provided at the bottom end of the liquid reservoir 33, a baffle f5 is provided inside the liquid conduit A34, and a pipe five 10 is provided on the circumferential outer wall of the liquid conduit A34 located below the baffle f5, and the pipe five 10 extends outwardly through one side of the interlayer sleeve 36; a wide range of pressurized inert gas is supplied through a gas pipeline connected by the same manifold E49 adjacent to the wet inert gas outlet pipe 48 to close the baffle e65, thereby closing the vacuum environment; at the same time, all the liquid is discharged to the subsequent module through another opened baffle f5.

[0453] Further preferably, a pressure-activated check valve b190 is provided on the circumferential outer wall of the liquid conduit A34 near the top end; the closing setting of the pressure-activated check valve b190 is used to contain the received liquid or discharge the liquid into the next module under the application of pressure.

[0454] In the separation module, the components contained in the specific composition in each intermittent amount delivered can be eluted by adsorbing the components onto the solid phase filler, and then eluting by modifying the eluent composition, and eluting the eluent itself in the recovery mixture after each intermittent amount delivered continuously. The eluent is processed and discharged from each intermittent amount delivered below, so that a specific component and another component of the components can be further adsorbed to a farther position along each discharge channel of the solid phase filler; after the liquid is transported in an intermittent amount, and discharged through the solid phase filler, the components contained in the transported liquid are allowed to be separated; after each intermittent amount of liquid is delivered to the top of the integral unit 95, a wide range of pressurized inert gas is provided to assist in rapid liquid discharge, while maintaining a vacuum at the outlet of the integral unit 95 set in the separation module to keep the solid phase filler in a semi-dry state, wherein the semi-dry state is a state with a wet surface but no liquid filling the gaps between the solid phase filler particles. After the delivery of the feed solution, the recovery mixture and the eluent is completed in sequence, one component and at least one other component contained in the feed solution can be migrated and separated by adsorption to the solid phase filler, and then the multiple recovery mixtures and at least one eluent are sequentially delivered to the respective storage tanks by sequential elution, at least one product of a specific concentrated product component and at least one by-product of another enriched component, and a plurality of components of a specific recovery mixture having a specific composition are dissolved in the discharge solution and the eluent for recovery.

[0455] exist Fig.15 It is shown that multiple separation modules C are operated in parallel at the same time, and the following is an example:

[0456] 1. Delivering all the circulating mixtures except the glucose residue of area 2 and the fructose product of area 15 from the downstream storage tank module through each of the above pipelines, with a predetermined volume from areas 0, 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, and area 19, as well as the circulating water collected from the bottom of the separation module; subsequently using an inert gas to flush the liquid residue after the circulating water input to maximize the recovery of fructose as the circulating liquid of area 19 to the designated storage tank in the upstream storage tank module 12; a plurality of lower storage tanks 44 arranged in an endless form in the downstream storage tank module are arranged in a hollow jacket 41, the jacket having a manifold F42 and a manifold G43 for water circulation to keep the entire plurality of lower storage tanks 44 within a selected temperature range;

[0457] 2. The recovered liquid is transported to the corresponding multiple upper storage tanks 15 in the upstream storage tank module 12 through the above pipeline. The upstream storage tank module 12 is arranged in the same annular form in the water circulation insulating jacket 11, and the jacket has a manifold A13 and a manifold B14 for water circulation;

[0458] 3. Delivering a predetermined volume of the entire designated circulation flow from the corresponding tanks in the upstream tank module 12 of the zones 0, 1, 3, 4, 5, 6, 7, the feed solution from its source, the elution water and the circulating water from its source in the zones 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, 19, and simultaneously through piping to the upstream rotary module to simultaneously receive the predetermined volume of liquid transferred from the specific tanks of the upstream tank module 12, and precisely delivering the predetermined volume of each liquid simultaneously to the top of each corresponding integral unit 95 of the module operating in parallel; once the top liquid delivery tank has completed receiving the entire liquid solution, it advances one rotation step in the predetermined rotation direction 20 by the rotating and positioning device and the sealing mechanism;

[0459] 4. Various liquids are transported to the following multiple separation modules operated in parallel through liquid pipelines, and inert gas is provided to the last group of units to remove the remaining liquid. After entering, the warm water circulates freely through the first integral unit 95 in each separation module, and then continues to enter the second integral unit 95, the third integral unit 95, until the water flows through all the closed unit compartments, and then leaves the interlayer jacket 36 through each manifold D27, so as to keep all the units installed in the multiple separation modules operating in parallel within the predetermined temperature range:

[0460] a. The specific liquid transferred as before through the respective pipes, only six such pipes are shown to simplify the drawing, is distributed in equal amounts through each manifold O79 disposed above the top of the specific unit through the top liquid inlet device of each integral unit 95, and is intermittently delivered by way of an integrated inert gas supply module for wetting a portion of the resin / adsorbent contained in the integral unit 95 to force the delivery liquid dosage through the resin / adsorbent to complete the desired mass transfer equilibrium contact between the two phases;

[0461] b. Maintaining the corresponding vacuum environment at the bottom of each integral unit 95 in the separation module in parallel operation to discharge a specific liquid into the corresponding reservoir 33 shown below and keep the resin / adsorbent in a semi-dry state;

[0462] c. The integrated inert gas supply module as above, each separation module operates in a closed loop, uniformly applied to the entire bottom of multiple separation modules operating in parallel, this vacuum environment is applied by the central vacuum pump 51; the wet inert gas is converted into dry inert gas through the aerosol separator 50, and the water liquid is collected in the water reservoir 52 for recycling; it means that the liquid quickly passes through the fixed resin / adsorbent particles, generating heterogeneous contact to achieve a mass transfer equilibrium contact state. This dry inert gas leaving the aerosol separator 50 is combined with pressurized dry air and deployed through the inert gas generator 54 to obtain fresh dry inert gas and stored in a steel tank container 55, maintained within a preferred wide range of pressure levels, ready to be deployed back to the top of each separation module operating in parallel, quickly forcing out the droplet amount of various liquids, and mass transfer equilibrium contact is carried out through the solid phase resin / adsorbent material, and the treated liquid is collected in the liquid reservoir 33 of each bottom integral unit 95 as a preferred operation, and transported into the downstream storage tank module 40.

[0463] 5. intermittently collecting various processed and discharged liquids from the bottom of the corresponding integral unit 95 of each separation module operating in parallel; wherein, through the corresponding manifolds set in each separation module, this same liquid is transported through each liquid pipeline to the downstream rotary module to accurately transport the predetermined volume of liquid, and once the liquid transfer storage tank has completed receiving the entire liquid solution, it is advanced by a rotation step in the predetermined rotation direction 20 together with the sealing mechanism through the rotating and positioning device;

[0464] 6. If Fig.15 As shown in the lower part, the entire liquid solution stored in the downstream spin-on module is transported to each designated lower storage tank 44 through a liquid pipeline; wherein the recovered water is used as water circulation, the low DS-glucose solution is used for other purposes, and the recovery streams of regions 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 and region 19; wherein the solution collected from region 2 is the raffinate of pure glucose, and the solution collected from region 15 is the product of pure fructose; wherein, as Fig.15 The downstream tank module 40 shown at the bottom is arranged in the same annular shape in the hollow jacket 41 to keep the entire plurality of tanks within a selected temperature range. Fig.15 As shown, the disclosed apparatus adopts a single-stage recovery procedure, and steps 1-6 are repeated as a steady-state operation process, with the aim of further subdividing the aforementioned separation of binary glucose and fructose through multiple separation modules operating in parallel at the same time to provide a solution for massive feed throughput.

[0465] Among them, the downstream rotary connection module includes a circular multi-valve body II37 driven by a driving member II, which is a rotating, positioning and sealing mechanism; the circular multi-valve body II37 [especially the horizontal circular plate b134] driven by the driving member II rotates forward or stops rotating intermittently at equal angles during operation around a selected direction, and the circular multi-valve body II37 is used as a part of the downstream rotary connection module for bridging and simultaneously transporting various liquids.

[0466] Preferably, the driving member II is electrically connected to the control module, and includes a servo motor II 148 and a brake II 149;

[0467] Furthermore, the circular multi-valve body II37 includes a horizontal circular plate b134, a stretching rod b150 fixedly connected to the inner wall of the horizontal circular plate b134, a plurality of transfer containers 38 arranged in a circular array on the top surface of the horizontal circular plate b134, and a plurality of output conduits 39 arranged in a circular array on the bottom surface of the horizontal circular plate b134 and equal in number to the transfer containers 38, and the bottom end of the stretching rod b150 is connected to the output end of the driving member II through a coupling; the transfer container 38 is used to receive various liquids discharged through each liquid conduit 34 of the separation module, and the setting of the output conduit 39 can accurately transmit specific liquids to the subsequent downstream storage tank module 40.

[0468] Preferably, a pressure-activated spring valve b133 is provided on the top outer wall of the transfer container 38, which is used to control the amount of liquid received by the storage.

[0469] Preferably, the top surface of the transfer container 38 is fixedly connected with an open end 132;

[0470] Furthermore, the top surface of the horizontal circular plate b134 is fixedly connected to an annular channel b135 with a 'U'-shaped cross-section, and the transfer container 38 is arranged inside the annular channel b135 to cover multiple components; the top surface of the annular channel b135 is fixedly connected to a connector c136, and the connector c136 is connected to the liquid conduit A34 at the bottom of the separation module, and the output end of the connector c136 is connected to the top of the open end 132 through the liquid conduit E137 after passing through the upper surface of the annular channel b135; so as to receive the liquid discharged from the separation module into the transfer container 38.

[0471] Preferably, a baffle i138 is fixedly connected to the inner wall of the transfer container 38 near the top, so that the liquid entering the storage container 21 can slide smoothly along the inner wall like an umbrella.

[0472] Further preferably, the bottom surface of the horizontal circular plate b134 is fixedly connected with an annular fixed chamber b146 having the same structure as the annular channel b135. Preferably, the gap between the annular fixed chamber b146 and the horizontal circular plate b134 is infinitely small, which can minimize the leakage of the pressurized inert gas and ensure the intermittent rotation of the horizontal circular plate b134. The bottom inner wall of the annular fixed chamber b146 is fixedly connected with wide open-top funnels b145 having the same number as the transfer container 38 and corresponding upper and lower positions; the bottom outer wall of the annular fixed chamber b146 is fixedly connected with a connector d147, and the connector d147 is connected to the outlet of the funnel b145, and the funnel b145 is connected to the output conduit 39; it is used to receive the liquid in the transfer container 38 and transport it to the next module.

[0473] Through the downstream rotary module, when the horizontal circular plate b134 is in a stationary state, a pressurized gas delivery mechanism is provided for the mobile phase liquid flow to discharge the delivered liquid into the designated lower storage tank 44 of the downstream storage tank module 40 and wait for another round of liquid delivery throughput.

[0474] Further preferably, the circumferential inner wall of the annular channel b135 is fixedly connected with an inner top railing b140 and an inner bottom railing b143 which match each other up and down, and the inner bottom railing b143 is fixedly connected to the top surface of the horizontal circular plate b134; the circumferential outer wall of the annular channel b135 is fixedly connected with an outer top railing b142 and an outer bottom railing b144 which match each other up and down, and the outer bottom railing b144 is fixedly connected to the top surface of the horizontal circular plate b134; so that the annular channel b135 can be connected and fixed to the horizontal circular plate b134.

[0475] Among them, the top surface of the inner top railing b140 is fixedly connected to the inner rim b139, and the top surface of the outer top railing b142 is fixedly connected to the outer rim b141; the matching inner bottom railing b143 and the matching outer bottom railing b144, the inner bottom railing b143 and the outer bottom railing b144 both have a flat and smooth surface to be tightly fixed to the top surface of the horizontal circular plate b102.

[0476] The inner walls of the concentric cavities formed between the inner top rail b140 and the inner bottom rail b143 and between the outer top rail b142 and the outer bottom rail b144 are filled with a plurality of balls b154; the balls b154 are arranged inside the concentric cavities with diameters slightly larger than the vertical heights thereof, thereby forming a small enough gap to control the free movement of the horizontal circular plate b134 through the centrally mounted driving member II;

[0477] In addition, an upper semi-arc groove 151 is provided at the center of the bottom surface of the outer top railing b142, which matches the lower semi-arc groove 152 provided at the center of the top surface of the outer bottom railing b144, and the upper semi-arc groove 151 and the lower semi-arc groove 152 are buckled to form the same concentric tunnel 153, and the diameter of the ball b154 is slightly larger than the vertical height of the concentric tunnel 153, thereby forming a gap b155; so that the horizontal circular plate b34 can be driven to move freely by the servo motor II 148.

[0478] The inner top railing b140 and the outer top railing b142 are provided with semicircular grooves e156 and h159 on both sides of the bottom surface, the inner bottom railing b143 and the outer bottom railing b144 are provided with semicircular grooves f157 and h159 on both sides of the top surface, and concentric circular tunnels c160 and d160 are formed between the inner top railing b140 and the inner bottom railing b143 and between the outer top railing b142 and the outer bottom railing b144. 1. The inner walls of the concentric circular tunnels c160 and the concentric circular tunnels d161 are respectively filled with O-ring seals 162; the diameter of the O-ring seals 162 is just large enough to seal the gap between the concentric circular tunnels c160 and the concentric circular tunnels d161, and the arrangement of the ball b154, the O-ring seals 162, etc. is used to provide sufficient frictionless rotation and positioning, as well as a sealing mechanism for the horizontal circular plate b134, and to provide minimal pressurized inert gas leakage and a sealing mechanism for such rotation and positioning.

[0479] Among them, the downstream storage tank module 40 includes a plurality of insulated heat medium circulation hollow sleeves 41 distributed in an array, and lower storage tanks 44 arranged inside the hollow sleeves 41 for receiving specific liquids. The hollow sleeves 41 are arranged into an organized array in a selected pattern; so as to keep the entire set of lower storage tanks 44 within a selected temperature range; each lower storage tank 44 is used to receive at least one separated product, a component in a specific solution mixture, and each lower storage tank 44 can recover a portion of the stored separation components in a predetermined volume back to the designated upper storage tank 15 in the upstream storage tank module 12.

[0480] Furthermore, the plurality of lower storage tanks 44 include at least one product storage tank for storing a specific concentrated component product, at least one by-product storage tank for storing at least one other concentrated component by-product, and a plurality of recovery mixtures sequentially contained in the lower storage tanks 44; so that each lower storage tank 44 contains a specific recovery mixture having a specific composition of components dissolved in the discharged solution, and an eluent collected from the bottom of the separation module, which is used to be recycled back to the corresponding upper storage tank 15 sequentially arranged in the upstream storage tank module 12.

[0481] Preferably, during each duration of the time period, the discharged liquid is distributed to one of the corresponding upper storage tanks 15 provided in the upstream storage tank module 12, which comprises:

[0482] ① a liquid having a specific composition of components dissolved in the discharge solution and the eluent, which liquid is the composition of the components contained in the discharged liquid for recovery;

[0483] ② When delivered in sequence within a specific time period, liquids from all liquids including the feed solution and the recovered mixture of the discharged liquid and the eluent collected within the same time period, i.e., a specific composition of the components dissolved in the discharged solution and the eluent, are respectively distributed to a corresponding one of the upper storage tanks 15, which is arranged in a specific area in the upstream storage tank module 12, and all these liquids are the composition of the components contained in the discharged liquid, and are arranged in the corresponding areas in a specified order, including the feed area, the regeneration area and the washing area;

[0484] In which, the lower storage tank 44 in the downstream storage tank module 40 contains a specific recovery mixture having a specific composition of components dissolved in the discharge solution and the eluent for recovery, and at least one product storage tank is used to hold a specific concentrated component product and a by-product storage tank is used to hold at least one other concentrated component by-product.

[0485] Furthermore, the top surface of the lower storage tank 44 is provided with an infusion conduit 45 that penetrates the outer wall of the hollow sleeve 41 and extends upward, and a baffle g6 is provided at the top of the infusion conduit 45, and the infusion conduit 45 receives liquid through the opened baffle g6;

[0486] Preferably, a pipe six 62 for supplying a high range of pressurized inert gas is provided on the top surface of the lower storage tank 44 located on one side of the infusion catheter 45; the infusion catheter 45 supplies a wide range of pressurized inert gas through the pipe six 62 as a driving force to open or close the baffle g6.

[0487] Furthermore, a drainage pipe 46 penetrating the outer wall of the hollow sleeve 41 and extending downward is provided on the bottom surface of the lower storage tank 44 . The drainage pipe 46 is connected to the volumetric pump, and the stored liquid can be discharged through the drainage pipe 46 .

[0488] Preferably, a liquid level sensor 63 for monitoring a predetermined liquid level of the stored liquid is provided inside the lower storage tank 44, and a liquid infusion pipe 64 is provided on the top surface of the lower storage tank 44; the liquid level sensor 63 can control the specific solution transported through the liquid infusion pipe 64 to maintain the predetermined liquid level in the corresponding lower storage tank 44, and at least one separated product can be placed in each designated product storage tank, and the components in the specific solution mixture can be discharged into each designated by-product storage tank, and a portion of the separated components stored in the respective lower storage tanks 44 can be recovered in a predetermined volume to each designated upper storage tank 15 in the above-mentioned upstream storage tank module 12.

[0489] Furthermore, the lower storage tank 44 includes a manifold F42 for connecting the warm water inlet and a manifold G43 for connecting the warm water outlet; the lower storage tank 44 is arranged in the warm water circulation hollow jacket 41, so that all the lower storage tanks 44 can be maintained within the selected temperature range.

[0490] Wherein, the inert gas supply module supplies a wide range of pressurized inert gas by establishing a closed loop, providing a mobile phase liquid flow transmission mechanism, including combining the upstream storage tank module 12, the upstream spin-on module, the separation module, the downstream spin-on module and the downstream storage tank module 40 with the liquid fluid transmission;

[0491] Further, the inert gas supply module includes a closed vacuum environment loop which is sequentially connected to form a closed loop and is arranged at the bottom of the integral unit 95, an upstream wide-area inert gas supply loop and a downstream wide-range inert gas supply loop which are arranged at the top of the integral unit 95, the upstream wide-area inert gas supply loop is used to supply gas between the upstream storage tank module 12 and the separation module, and the downstream wide-range inert gas supply loop is used to provide gas supply to the bottom area of ​​multiple integral units 95 in the separation module and the downstream storage tank module 40;

[0492] The closed vacuum environment loop includes an aerosol separator 50, a liquid reservoir 33 for receiving liquid discharge, a central vacuum pump 51 for extracting wet inert gas rich in mobile phase liquid mist, a water reservoir 52, a liquid guide tube 53 fixedly connected to the bottom surface of the water reservoir 52, an inert gas generator 54 and a steel tank container 55, and the gas outlet of the aerosol separator 50 is connected to one end of the central vacuum pump 51 and the water reservoir 52 through a conveying conduit, and the inlet and outlet ends of the inert gas generator 54 are respectively connected to the gas outlet end of the central vacuum pump 51 and the gas inlet end of the steel tank container 55;

[0493] Preferably, the air inlet of the aerosol separator 50 is connected to a manifold P84, and the output end of the manifold P84 is connected to the input end of multiple outlet pipes 48; the central vacuum pump 51 extracts wet inert gas rich in mobile phase liquid mist through multiple outlet pipes 48, and after being collected by the manifold P84, it enters the aerosol separator 50 and is converted into dry inert gas.

[0494] This structure extracts the wet inert gas rich in mobile phase liquid mist to apply driving force from the central vacuum pump 51 through its manifold, and recovers the mobile phase liquid mist in the wet inert gas through the gas mist separator 50, so that the resin installed in each integral unit 95 of the separation module is kept in a semi-dry state, and at the same time, when the dripping liquid dose quickly passes through the fixed resin / adsorbent particles, heterogeneous contact is generated to meet the standards of the new mass transfer equilibrium contact method, thereby generating heterogeneous contact and obtaining the treated liquid. During the entire duration, the dry inert gas is combined with the pressurized dry air and passed through the deployed inert gas generator 54 to obtain fresh dry inert gas stored in the steel tank container 55, maintaining the preferred wide range of pressure levels of the inert gas.

[0495] Further preferably, the vacuum degree of the closed vacuum environment loop is 15 to 27 in-Hg, keeping the solid resin / adsorbent material in a semi-dry state, and wherein the vacuum is applied from the bottom of the integral unit 95 to remove the mobile phase liquid filled in the resin / adsorbent matrix in the shortest possible time.

[0496] The upstream wide-area inert gas supply loop includes a one-way gas pipeline 66 connected to the medium-pressure gas outlet of the steel tank container 55, a manifold H67 connected to the input end of the pipeline 28 and the output end of the one-way gas pipeline 66, a two-way gas pipeline 68 connected to the low-pressure gas outlet of the steel tank container 55, a manifold J69 connected to the input end of the pipeline 17 and the output end of the two-way gas pipeline 68, a three-way gas pipeline 70 connected to the high-pressure gas outlet of the steel tank container 55, and a manifold J69 connected to the input end of the pipeline 17 and the output end of the two-way gas pipeline 68. 9 input end and the output end of the three-way gas pipeline 70, an online gas temperature regulator 56 connected to the output end of the steel tank container 55 at one end, a four-way gas pipeline 72 connected to the output end of the online gas temperature regulator 56, and a manifold L57 connected to the input end of the pipeline 4 30 and the output end of the four-way gas pipeline 72, and the pipeline 4 30 is set on the top surface of the integral unit 95; used to simultaneously and intermittently receive the supply of high-range pressurized dry inert gas. Pipeline three 9 is used to input high-range pressurized dry inert gas into the corresponding storage 28. Pipeline two 8 is set on the circumferential outer wall of the outlet conduit 17 to allow medium-pressure dry inert gas to enter. Pipeline one 7 is set on the top outer wall of the upper storage tank 15 to supply dry low-range pressurized inert gas. Before the four-way gas pipeline 72 supplies high-range pressurized inert gas to each pipe 24 30 through the manifold L57, an embedded online gas temperature regulator 56 is set to ensure that the fresh dry inert gas is maintained slightly above the temperature range of all types of liquid solutions to prevent microbial growth.

[0497] Preferably, the upstream storage tank module 12, the downstream storage tank module 40 and the separation module are all maintained within the same predetermined temperature range to meet the target separation system requirements.

[0498] Through a gas delivery line 66 connected to the steel tank container 55, the medium-range pressurized inert gas is sequentially supplied to each pipe 28 through the manifold H67, and the low-range pressurized inert gas supplied by the pipe 17 is closed, so that the baffle a1 is opened to allow a predetermined amount of liquid to be output from the lower storage tank 44 in the downstream storage tank module 40 after passing through each volumetric pump, and the baffle b2 is pushed upward to prevent the liquid from flowing downward, so as to temporarily store the transported liquid into each upper storage tank 15 in the upstream storage tank module 12; then the pipe 28 is closed to stop the supply of medium pressure Inert gas, at the same time, through the two-way gas pipeline 68 extending from the steel tank container 55, the low-range pressurized inert gas is transported to each pipeline 1 7 in turn through the manifold J69, and at the same time, the high-range pressurized inert gas is transported to the pipeline 3 9 through the manifold K71 through the three-way gas pipeline 70. During the gas supply, the baffle a1 and the baffle c3 will be closed, and the baffle b2 will be opened, so that the liquid can be transported from the upper storage tank 15 to the storage container 21 through the outlet conduit 17, and the circular multi-valve body Ⅰ19 in the upstream rotary joint module advances one rotation step.

[0499] After the circular multi-valve body Ⅰ19 stops operating, the low-range pressurized inert gas supplied through pipeline 1 7 and the high-range pressurized inert gas supplied through pipeline 3 9 are quickly closed, and the steel tank container 55 supplies the medium-range pressurized inert gas through pipeline 2 8. At the same time, the high-range pressurized inert gas is supplied to each pipeline 4 30 through the four-way gas pipeline 72 through the manifold L57, and the baffle b2 and the baffle d4 are closed, so that all the liquid in the storage container 21 is transmitted to the corresponding transfer storage 28 located at the top of the separation module c through the open baffle c3.

[0500] After the above operation is completed, the high-range pressurized inert gas is re-supplied through the pipeline three 9 within a predetermined time, so that the baffle c3 is closed, and the high-range pressurized inert gas supplied through the pipeline four 30 is closed at the same time, so that the liquid stored in the reservoir 28 quickly passes through the baffle d4, so that the liquid dripping in a relatively long period of time quickly wets the top part of the installed solid resin. Then, the pipeline four 30 is immediately opened to supply the pressurized inert gas, and the pipeline three 9 is closed to cut off the supply of the high-range pressurized inert gas, so that the baffle d4 is pushed up to prevent the liquid from dripping; and at the same time, the dripping liquid is pushed to quickly pass through the resin contained in each integral unit to complete the expected new mass transfer equilibrium contact method between the two phases; by repeatedly alternating the opening and closing of the supply of the inert gas between the pipeline three 9 and the pipeline four 30, the liquid stored in the reservoir 28 is separately input at a predetermined liquid dosage within a specific time to complete the differential setting program scheme adopted between the solid phase and the liquid phase.

[0501] The downstream wide-range inert gas supply loop includes a five-way gas pipeline 73 connected to another medium-pressure gas outlet of the steel tank container 55, a manifold M74 connected to the input end of the pipeline five 10 and the output end of the five-way gas pipeline 73, a six-way gas pipeline 75 connected to another high-pressure gas outlet of the steel tank container 55, and a manifold N76 connected to the input end of the pipeline six 62 and the output end of the six-way gas pipeline 75;

[0502] Through the five-way gas pipeline 73 connected to the steel tank container 55, medium-pressure inert gas is supplied to each pipe five 10 in turn through the manifold M74, so that when the vacuum box 31 is applied, the baffle f5 is pushed upward to store the discharged liquid in the corresponding liquid reservoir 33; after the discharge is completed, the vacuum box 31 and the medium-pressure inert gas supplied through the pipeline five 10 are closed, and at the same time, the low-range pressurized inert gas supplied through the manifold E49 and the high-pressure inert gas supplied from the manifold N76 to the pipeline six 62 through the six-way gas pipeline 75 are opened in turn, so that the baffle e65 in the funnel-shaped liquid collecting conduit 32 and the baffle g6 in the liquid delivery conduit 45 are pushed up and closed at the same time, and the baffle f5 in the liquid conduit 34 is opened, so that all the liquid in each liquid reservoir 33 is transferred to each transfer container 38 in the downstream rotary joint module at the same time. After multiple circular multi-valve bodies II 37 are in operation, the supply of medium-pressure inert gas through pipeline five 10 is immediately restored, and the supply of high-pressure inert gas through pipeline six 62 is shut off, so that the baffle 5 is closed, and the liquid in each transfer container 38 pushes the baffle g6 open through the infusion conduit 45 and enters the corresponding lower storage tank 44 in the downstream storage tank module 40, and the circular multi-valve body II 37 in the downstream rotary joint module advances one rotation step.

[0503] Preferably, the inert gas is one of nitrogen, carbon dioxide, argon and air, or a mixture of gases, to reduce the oxidization of oxygen and the obstruction of the resin / adsorbent to the long-term separation efficiency. In this embodiment, the inert gas is preferably air.

[0504] Further preferably, the pressure level of the medium range pressurized inert gas in the upstream tank module 12 is 55-70 psi, which is used to provide sufficient pressure to the mechanical baffle b2 to close it, so as to maintain the weight of the entire transmission liquid;

[0505] Further preferably, the pressure level of the low-range pressurized inert gas in the upstream tank module 12 is 40-55 psi, which serves as the gas providing the driving force for closing the baffle a1, providing sufficient pressure to quickly push the liquid into the next area;

[0506] Further preferably, the pressure level of the low-range pressurized inert gas on the separation module is 40-55 psi, which is used to provide the driving force for closing the baffle e65;

[0507] Further preferably, the pressure level of the medium range pressurized inert gas on the separation module is 55-70 psi, which is used to provide the driving force for closing the baffle f5;

[0508] Further preferably, the pressure level of the high-range pressurized inert gas on the downstream tank module 40 is 70-90 psi, which is used to provide the driving force for closing the baffle g6.

[0509] A4: The general separation process adopts a differential setting program scheme through the general procedure of the new mass transfer equilibrium contact method: adopting a predetermined matching mobile phase input mode selected between SI mode and II mode to obtain a characteristic separation curve of a specific separation system related to the selected resin / adsorbent solid phase, and combining various mobile phase liquid solutions into a parameter differential moving bed for continuously and simultaneously separating at least one desired component from the liquid solution mixture within each minimum time interval;

[0510] Among them, it includes setting at least one area corresponding to at least one first mobile phase flow, setting at least one area corresponding to at least one second mobile phase flow, setting at least one area corresponding to at least one third mobile phase flow, and predetermined multiple alternative circulating mobile phase flows returning to the predetermined area; all areas are combined together in sequence to represent the obtained characteristic separation curve, and the chromatographic mass transfer mechanism of the solid phase is converted from the flow direction of the parallel path of the mobile phase to the vertical path, and this differential setting program protocol is further organized into a parameter differential moving bed.

[0511] Further, the differential setting program scheme includes a predetermined plurality of alternative recycling mobile phase flows for intermittent delivery to the parameter differential moving bed;

[0512] Wherein, the mobile phase flow replaces at least one first mobile phase flow in the corresponding upper storage tank 15 stored in the upstream storage tank module 12;

[0513] Or: the mobile phase flow replaces at least one corresponding second mobile phase flow stored in the corresponding upper storage tank 15 in the upstream storage tank module 12;

[0514] Alternatively, the mobile phase flow replaces at least one corresponding third mobile phase flow stored in the corresponding upper storage tank 15 in the upstream storage tank module 12 .

[0515] The differential setup scheme through steps i)-iii) in A1 is used to apply the general procedure of the new mass transfer equilibrium contact method to the construction of a single monolithic unit 95, by predetermining the selected mobile phase between the combination of input SI mode and input II mode to obtain a characteristic separation curve for a specific separation system between selected resins / adsorbents associated with various mobile phase liquids in steps A2-A3, entering into a parametric differential moving bed comprising a single monolithic unit 95 to separate at least one desired component from a liquid solution in the sum of multiple minimum time intervals accumulated in the time domain.

[0516] Furthermore, the differential setting program scheme applied to the parameter differential moving bed includes the following steps:

[0517] B1: Determine the optimal full-strength adsorption amount of resin / adsorbent at a predetermined feed throughput and divide the amount by a pre-selected number; preferably, the number divides the resin / adsorbent into the same sub-amount in at least one single column 23 disposed in a single integral unit 95 to simultaneously receive the same resin / adsorbent sub-amount of multiple partial volume liquid droplets disposed in each integral unit 95 in a specific area;

[0518] Preferably, the preselected number is equal to the number of single columns 23 provided in a single integral unit 95 in each region.

[0519] B2: In the general procedure of the new mass transfer equilibrium contact method, between the selected input modes SI mode and II mode, a characteristic elution curve represented in the time domain is generated according to a predetermined type of liquid distributor, by intermittently delivering a predetermined volume of a feed solution containing one component and at least one other component to the integral unit 95, and then by the general procedure of the new mass transfer equilibrium contact method, after the introduction of the feed solution, by intermittently delivering a plurality of circulating streams and eluents of predetermined volumes in a specific order, the adsorbed components are sequentially eluted to obtain at least one specific concentrated product component, to obtain another concentrated component of at least one by-product, and to obtain a plurality of recovered mixtures;

[0520] Preferably, a specific recovery mixture in the mixture has a specific composition of components that are dissolved in the discharged solution and the eluent.

[0521] B3: Decompose the elution curve in sub-time order in the total cumulative time domain, and then divide each sub-time by the minimum time interval to obtain the range of the number of overall cells 95 set as the corresponding region;

[0522] Preferably, the sub-time units are used for the input of the corresponding mobile phase solutions in the corresponding areas, including the most time-consuming areas and the less time-consuming areas for various types of input liquids.

[0523] B4: Divide the total input volume of the mobile phase solution by the number of integral units 95 to obtain the partial volume required for the minimum time interval each time in the corresponding area, and then divide the partial volume by a pre-selected number to further distinguish as multiple continuous liquid droplets; in order to simultaneously carry out the general procedure of the new mass transfer equilibrium contact method, the resin / adsorbent in each integral unit 95 set in the separation module is sequentially passed through.

[0524] B5: All integral units 95 with each liquid are assigned as ranges of specific liquid areas;

[0525] B6: Arrange all liquid zones in the same order in a parametric differential moving bed in an infinite cycle for various transported liquids;

[0526] Preferably, all the regions orderly arranged in the same sequential form are integrated and combined to represent a complete elution separation cycle, and various mobile phases with limited parameter solution mixtures are delivered to the fixed separation module below through a predetermined selected mobile phase combination between the input II mode and the input SI mode;

[0527] Further preferably, all areas arranged in an endless format are integrated together through an upstream rotary module and a downstream rotary module, indicating that the elution curve separation cycle is completed within the minimum time interval, and various mobile phase parameter solutions are transferred to the fixed separation module below to simulate all units set in the simulated horizontal movement direction, while the mobile phase moves in the vertical direction at the same time.

[0528] Among them, all the regions are integrated and combined in the same order, and the specific operations are:

[0529] B61: providing at least one region between the selectively introduced at least one amount of the first mobile phase flow and the plurality of first discrete mobile phase flows, in contact with the installed resin / adsorbent packing in the time domain, to perform the intended mass transfer contact as the first mobile phase region;

[0530] B62: providing at least one region between the selective introduction of at least one amount of the second mobile phase flow and the plurality of second discrete mobile phase flows, in contact with the installed resin / adsorbent packing in the time domain, to perform the intended mass transfer contact as the second mobile phase region;

[0531] B63: providing at least one region between the selective introduction of at least one amount of the third mobile phase flow and the plurality of third discrete mobile phase flows, in contact with the disposed resin / adsorbent filler in the time domain, to perform the intended mass transfer contact as the third mobile phase region;

[0532] B64: providing at least one region between the selective introduction of at least one amount of a fourth, fifth, etc. mobile phase flow and a plurality of fourth, fifth, etc. discrete mobile phase flows, in contact with the disposed resin / adsorbent packing in the time domain for the intended mass transfer contact as a corresponding fourth, fifth, ... and so on, until all adsorbates in the mobile phase region are sequentially eluted;

[0533] B65: setting at least one zone corresponding to the introduction of at least one last mobile phase flow in contact with the treated resin / adsorbent packing in the time domain to perform the expected mass transfer contact as the last mobile phase zone;

[0534] B66: and predetermined multiple replacement circulating mobile phase flows return to the predetermined above-mentioned areas to replace the solutions set in the above-mentioned corresponding areas, so as to increase the concentration of the separated components and save the consumption of the corresponding solutions;

[0535] B67: The entire area of ​​each of the above regions is sequentially integrated to obtain a characteristic separation curve for eliminating the chromatographic substitution zone and further arranging this difference scheme.

[0536] B7: The predetermined volumes of various specific recovery mixtures in step B2 are prepared in sequence into the corresponding lower storage tanks 44 in the downstream storage tank module 40 to support liquid distribution through the closed loop of the upstream storage tank module 12, the upstream rotary module, the separation module, especially the single integral unit 95, the downstream rotary module, and the downstream storage tank module 40, and then returned to the downstream storage tank module 40 through the driving force provided by the mobile phase liquid flow transmission mechanism.

[0537] Further preferably, the preselected number is a finite integer ≥ 1, wherein, when the integer is equal to 1, the B1 contains a predetermined amount of solid phase resin / adsorbent as a single integral unit 95 itself distributed in a single column 23.

[0538] A5: The generalized separation process adopts a single-stage recovery program scheme on a parameter differential moving bed through a new mass transfer equilibrium contact method: through a mobile phase liquid flow transmission mechanism together with each module arranged in the parameter differential moving bed, so as to simultaneously and intermittently transport each mobile phase liquid flow originally stored in a corresponding upper storage tank 15 arranged in an upstream storage tank module 12 to the separation module for the expected new mass transfer equilibrium contact method;

[0539] Among them, the multiple mobile phase liquid flows recovered by the separation module include at least one product, at least one by-product, and multiple recovered liquid flows transported to the designated lower storage tank 44 set in the downstream storage tank module 40, and further transport the multiple circulating flows with stable composition and concentration characteristics back to the predetermined area set in the upstream storage tank module 12, and return to the predetermined area set in the upstream storage tank module 12 together with other mobile phase liquid flows, and then repeatedly transport the recovered liquid flow back to the designated lower storage tank 44 set in the downstream storage tank module 40 through the separation module as a single-stage recovery procedure.

[0540] Further, the single-stage recovery procedure is used to transfer all kinds of liquids on a parameter differential moving bed through a general procedure of a new mass transfer equilibrium contact method and a differential setting procedure between two phases for recovering multiple streams and eluents;

[0541] Preferably, all types of liquids include a feed liquid containing one component and at least one other component and a plurality of recovered mixtures containing a specific composition of the component dissolved in the discharged solution and the eluent;

[0542] Preferably, the plurality of streams include a particular concentrated product component of at least one product, another enriched component of at least one by-product, and a plurality of recovered mixtures containing a particular combination of components dissolved in the effluent solution.

[0543] The single-stage recovery procedure is used in a parametric differential moving bed to achieve the following separation process applicable to a single integral unit 95:

[0544] Ⅰ: Maintain all upper storage tanks 15 in the upstream storage tank module 12 within a selected temperature range, wherein:

[0545] ① at least one upper storage tank 15 is arranged in the first mobile phase area, each upper storage tank 15 contains at least one predetermined selected first mobile phase flow and a plurality of first discrete mobile phase flows;

[0546] ② at least one upper storage tank 15 is arranged in the second mobile phase area, each upper storage tank 15 contains at least one predetermined selected second mobile phase flow and a plurality of second discrete mobile phase flows;

[0547] ③ installing at least one upper storage tank 15 in the third mobile phase zone, each upper storage tank 15 containing at least one predetermined selected third mobile phase flow and a plurality of third discrete mobile phase flows;

[0548] ④ at least one upper storage tank 15 is arranged in the fourth, fifth, and so on mobile phase zones, each upper storage tank 15 contains at least one predetermined fourth, fifth mobile phase flow and a plurality of fourth, fifth, etc. discrete mobile phase flows;

[0549] ⑤ At least one upper storage tank 15 is arranged in the last mobile phase zone, and each upper storage tank 15 contains at least one predetermined selected last discrete mobile phase flow.

[0550] II: Keep all lower storage tanks 44 in the downstream storage tank module 40 within a selected temperature range, wherein:

[0551] At least one lower storage tank 44 is allocated to receive liquid delivered from a specific upper storage tank 15, which is arranged in the upstream storage tank module 12 of the first mobile phase zone, and at least one predetermined first mobile phase flow and multiple first discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method; as a treated liquid to promote the adsorption of at least one solute component collected from the liquid reservoir 33 arranged at the bottom of the separation module, as a liquid storage tank arranged in the feed zone area 1.

[0552] Preferably, the mobile phase comprises a feed liquid mobile phase of at least one desired component and a solute mixture separated from at least one other component as a homogeneous liquid solution mixture of limited components; the homogeneous liquid solution mixture is contacted with a resin / adsorbent to promote adsorption.

[0553] Further preferably, the solute composition is dissolved in a solution in discrete increments of parameters with increasing discrete parameters so as to achieve a desired new mass transfer equilibrium contact method so that at least one of the components can be sequentially desorbed from the resin / adsorbent, which is a granular normal phase resin / adsorbent.

[0554] At least one lower storage tank 44 is designated to receive liquid delivered from a specific upper storage tank 15, which is arranged in the upstream storage tank module 12 of the second mobile phase zone, and at least one predetermined second mobile phase flow and a plurality of second discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method; as a treated liquid to promote the elution of a specific adsorbed solute mixture component collected from the liquid reservoir 33 arranged at the bottom of the separation module, as a liquid storage tank arranged in area 2.

[0555] At least one lower storage tank 44 is designated to receive liquid delivered from a specific upper storage tank 15, which is arranged in the upstream storage tank module 12 of the third mobile phase zone, and at least one predetermined selected third mobile phase flow and multiple third discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method; as a treated liquid to promote the elution of a specific adsorbed solute mixture component collected from the liquid reservoir 33 arranged at the bottom of the separation module, as a liquid storage tank arranged in area 3.

[0556] At least one lower storage tank 44 is designated to receive liquid delivered from a specific upper storage tank 15 of an upstream storage tank module 12 set in a fourth, fifth, etc. mobile phase zone, at least one predetermined selected fourth, fifth, etc. mobile phase flow and a plurality of fourth, fifth, etc. discrete mobile phase flows are contacted with the resin / adsorbent solid phase filler to obtain a new mass transfer equilibrium contact method; as a treated liquid to promote the elution of a specific adsorbed solute mixture component collected from a liquid reservoir 33 set at the bottom of the separation module, as a liquid storage tank set in zones 4, 5, etc.

[0557] At least one lower storage tank 44 is designated to receive liquid delivered from a specific upper storage tank 15, which is arranged in the last mobile phase zone of the upstream tank module 12, and at least one predetermined last mobile phase flow and last discrete mobile phase flow are in contact with the resin / adsorbent solid phase filler to clean and wash away the residual resin / adsorbent solid filler; as a treated liquid to promote the elution of a specific adsorbed solute mixture component collected from the reservoir 33 arranged at the bottom of the separation module, as a liquid storage tank arranged in the last area.

[0558] according to - The step allocates at least one product storage tank for holding a specific concentrated component product, at least one by-product storage tank for holding at least one other concentrated component by-product, and then prepares each circulating liquid flow according to the obtained elution curve, and its dissolved limited solute composition specifically modifies the characteristic parameters of the eluent solution mixture; thereby integrating a full spectrum set representing various liquids that produce characteristic elution curves, which are set in each lower storage tank 44 of the downstream storage tank module 40.

[0559] Preferably, the eluent mixture is capable of eluting a particular adsorbed solute mixture component from corresponding lower storage tanks 44 arranged in sequence, such as zones 1, 2, 3, 4, 5, etc., and a "last zone" to accommodate the eluent flowing from its source.

[0560] III: The single integral unit 95 is further operated together with the mobile phase liquid flow transmission mechanism through the new mass transfer equilibrium contact method, and each mobile phase liquid stored in the corresponding area of ​​the corresponding upper storage tank 15 is sequentially dripped into the separation module in a predetermined volume format in the above order to produce the expected new mass transfer equilibrium contact method, and the liquid is continuously delivered according to the repeated procedure after each dripping, and once the predetermined amount of liquid solution is completed, it is distributed and delivered to the reservoir 28 at the top of the single integral unit 95, wherein:

[0561] a) in a first time period, intermittently delivering a forced discharge dose of liquid dripping from the top of a single integral unit 95 through an alternating supply mode between two separate wide range pressurized inert gas routes to rapidly pass through the resin / adsorbent to complete a new mass transfer equilibrium contact method between the two phases to promote adsorption of components onto the resin / adsorbent or to elute adsorbed components from the resin / adsorbent;

[0562] 2) while maintaining the vacuum environment at the bottom of the integral unit 95, draining the treated liquid solution into the reservoir 33 below, and keeping the resin / adsorbent in a semi-dry state;

[0563] 3) during the second time period, intermittently collecting the discharged liquid in the liquid reservoir 33 and delivering the collected liquid to each designated lower storage tank 44 in the downstream storage tank module 40;

[0564] iv) repeating steps 1) to 3) to complete all liquids set in at least one upper storage tank 15 set in the first mobile phase zone, through which the liquid collected from the bottom of the integral unit 95 is transferred as a circulating flow to the designated lower storage tank 44 of the last mobile phase zone to increase the concentration level of the eluted components to save solution consumption or other use;

[0565] Preferably, all liquids include feed solution, multiple circulating liquid streams in zones 1, 2, 3, 4, 5, etc.;

[0566] V) repeating steps 1) to 3) to complete all liquids set in at least one upper storage tank 15 set in the second mobile phase zone, and transferring the liquid collected from the bottom of the unit 95 as a circulating flow back to the designated lower storage tank 44 of the second mobile phase zone to increase the concentration level of the eluted components to save solution consumption or other use;

[0567] vi) repeating steps 1) to 3) to complete all liquids set in at least one upper storage tank 15 set in the third mobile phase zone, and transferring the liquid collected from the bottom of the integral unit 95 back to the designated lower storage tank 44 of the third mobile phase zone as a circulating flow to increase the concentration level of the eluted components to save solution consumption or other use;

[0568] VII) repeating steps 1) to 3) to complete all liquids being set in at least one upper storage tank 15, the upper storage tank 15 being set in the fourth, fifth, etc. mobile phase zones, through which the liquid collected from the bottom of the integral unit 95 is transferred as a circulating flow back to the corresponding fourth, fifth, etc. mobile phase zones in the designated lower storage tank 44 to increase the concentration level of the eluted components to save solution consumption or other use;

[0569] VIII) Steps i) to iii) are repeated to complete the setup of all liquids, with at least one upper storage tank 15 being arranged in the last mobile phase zone, through which the liquid collected from the bottom of the integral unit 95 is transferred as a circulating flow back to the designated lower storage tank 44 of the first mobile phase zone to be adjusted and mixed with the components in the feed solution to save solution consumption or other uses.

[0570] Alternatively, the single-stage recovery procedure is employed in a parametric differential moving bed to achieve the following separation process applicable to a single integral unit 95:

[0571] Ⅰ: Maintain all lower storage tanks 44 in the downstream storage tank module 40 within a selected temperature range, wherein:

[0572] At least one lower storage tank 44 is allocated to receive the liquid collected and discharged from the matching specific multiple integral units 95, and the lower storage tank 44 is arranged in the downstream storage tank module 40 of the first mobile phase zone, and at least one predetermined first mobile phase flow and a plurality of first discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method;

[0573] At least one lower storage tank 44 is allocated to receive the liquid collected and discharged from the matching specific multiple integral units 95, and the lower storage tank 44 is arranged in the downstream storage tank module 40 of the second mobile phase zone, and at least one predetermined second mobile phase flow and a plurality of second discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method;

[0574] At least one lower storage tank 44 is allocated to receive the liquid collected and discharged from the matching specific multiple integral units 95, and the lower storage tank 44 is arranged in the downstream storage tank module 40 of the third mobile phase zone, and at least one predetermined third mobile phase flow and a plurality of third discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method;

[0575] At least one lower storage tank 44 is allocated to receive the liquid collected and discharged from the matching specific multiple integral units 95, and the lower storage tank 44 is arranged in the downstream storage tank module 40 of the fourth and fifth mobile phase zones, and at least one predetermined fourth and fifth mobile phase flow and a plurality of fourth and fifth discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method;

[0576] At least one lower storage tank 44 is allocated to receive the liquid collected and discharged from the matching specific multiple integral units 95, and the lower storage tank 44 is arranged in the downstream storage tank module 40 of the last mobile phase zone, and at least one predetermined last mobile phase flow and a plurality of last discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to clean and wash away the residual resin / adsorbent solid filler;

[0577] exist After the last lower storage tank 44 of the last mobile phase zone in the middle, a lower storage tank 44 is provided to receive the corresponding pressurized inert gas from its source into the designated integral unit 95 top reservoir 28 to flush the remaining liquid in the resin / adsorbent solid phase packing to maintain a semi-dry state of the new mass transfer equilibrium contact method;

[0578] according to - The steps of allocating at least one product storage tank for holding a specific concentrated component product, at least one byproduct storage tank for holding at least one other concentrated component byproduct, and then preparing each circulating liquid stream based on the obtained elution profile, the composition of dissolved limiting solutes specifically modifying the characteristic parameters of the eluent solution mixture;

[0579] II: The plurality of integral units 95 are further operated together with the mobile phase liquid flow transmission mechanism through the new mass transfer equilibrium contact method, and the mobile phase liquids stored in the corresponding areas of the corresponding lower storage tanks 44 are simultaneously and sequentially dripped into the separation module in a predetermined volume format in the above order to produce the expected new mass transfer equilibrium contact method, and the liquid is continuously delivered according to the repeated procedure after each dripping, and once the predetermined amount of liquid solution is completed, it is distributed and delivered to the reservoirs 28 at the top of each integral unit 95, wherein:

[0580] a) in a first time period, intermittently delivering a forced discharge dose of liquid dripping from the top of a single integral unit 95 through an alternating supply mode between two separate wide range pressurized inert gas routes to rapidly pass through the resin / adsorbent to complete a new mass transfer equilibrium contact method between the two phases to promote adsorption of components onto the resin / adsorbent or to elute adsorbed components from the resin / adsorbent;

[0581] 2) while maintaining the vacuum environment at the bottom of the integral unit 95, draining the treated liquid solution into the reservoir 33 below, and keeping the resin / adsorbent in a semi-dry state;

[0582] 3) during the second time period, intermittently collecting the discharged liquid in the liquid reservoir 33 and delivering the collected liquid to each designated lower storage tank 44 in the downstream storage tank module 40;

[0583] iv) repeating steps 1) to 3) to complete all liquids set in at least one lower storage tank 44 set in the first mobile phase zone, and the liquid collected from the bottom of the integral unit 95 is transferred therethrough as a circulating flow to the designated lower storage tank 44 of the last mobile phase zone;

[0584] 5) repeating steps 1) to 3) to complete all the liquids disposed in at least one lower storage tank 44 disposed in the second mobile phase zone, and transferring the liquid collected from the bottom of the integral unit 95 back to the designated lower storage tank 44 of the second mobile phase zone as a circulating flow;

[0585] vi) repeating steps 1) to 3) to complete all the liquids disposed in at least one lower storage tank 44 disposed in the third mobile phase zone, and transferring the liquid collected from the bottom of the integral unit 95 back to the designated lower storage tank 44 of the third mobile phase zone as a circulating flow;

[0586] VII) repeating steps 1) to 3) to complete the placement of all liquids in at least one lower storage tank 44, the lower storage tank 44 being placed in the fourth and fifth mobile phase zones, and the liquid collected from the bottom of the integral unit 95 being transferred as a circulating flow back to the corresponding lower storage tank 44 designated in the fourth, fifth, etc. mobile phase zones;

[0587] VIII) repeating steps 1) to 3) to complete the setting of all liquids, at least one lower storage tank 44 is set in the last mobile phase zone, and the liquid collected from the bottom of the integral unit 95 is transferred back to the designated lower storage tank 44 of the first mobile phase zone as a circulating flow;

[0588] Preferably, the eluent mixture is capable of eluting a specific adsorbed solute mixture component from corresponding lower storage tanks 44 arranged in sequence, such as zones 1, 2, 3, 4, 5, etc., and a "last zone" to hold the eluent flowing from its source, followed by a last tank to hold the remaining liquid after the last zone is flushed by the pressurized inert gas.

[0589] Through the new mass transfer equilibrium contact method to produce at least one desired component to migrate through various circulating flows, in each rapid drop of liquid dosage of the eluent solution mixture with specific modified characteristic parameters, to further gradually separate at least one of the components from at least one other component, so as to obtain such separation result of the characteristic separation curve within the main time interval. In addition, the treated discharged liquid is transported back to each designated lower storage tank 44 in the downstream storage tank module 40 through the mobile phase liquid flow delivery mechanism, and each corresponding lower storage tank 44 contains a plurality of recovery mixtures in order for repeated recovery to the corresponding designated liquid reservoir 33 at the top of the separation module.

[0590] The mobile phase simultaneously introduces a feed liquid mobile phase containing at least one desired component and at least one other component to separate a solute mixture as a uniform liquid solution mixture of limited components; the solute composition is dissolved in the solution in discrete increments of parameters with increasing discrete parameters so as to achieve a desired new mass transfer equilibrium contact method so that at least one of the components can be sequentially desorbed from the resin / adsorbent.

[0591] The operation contents of the single-stage recycling procedure include the following supplements:

[0592] C1: The liquid is transported in a closed loop, starting from the downstream storage tank module 40, through the upstream storage tank module 12 attached to the pressurized inert gas supply module, as well as the rotating and positioning device and the sealing mechanism in the upstream rotary module, to complete the new mass transfer equilibrium contact method in the separation module, and then returns to the downstream storage tank module 40 together with the rotating and positioning device and the sealing mechanism in the downstream rotary module; wherein, depending on the separation system, the separation process applicable to a single integral unit 95 may consider avoiding the upstream rotary module and the downstream rotary module; the separation system applicable to the separation process of multiple integral units 95 may consider avoiding the upstream storage tank module 12, the upstream rotary module and the downstream rotary module, and still transport the liquid through the pressurized inert gas supply module.

[0593] Furthermore, the C1 step also includes the following broad contents:

[0594] C11: the integral unit 95 located in the first position in the separation module receives a predetermined volume of liquid delivery, while the remaining integral units 95 do not receive liquid, the liquid is sequentially and simultaneously transferred from the lower tank 44 to the upper tank 15 and is associated with a wide range of pressurized inert gas supply through the reservoir 28;

[0595] In addition, predetermined volumes of various liquids arranged in a specific order in various circulating flows provide feed solutions from their sources, as well as another plurality of circulating flows arranged in a specific order, and then eluents are delivered from their sources, and finally inert gas flushing is introduced to discharge the remaining liquids. The delivery of all the above liquids is directly related to the supply of a wide range of pressurized inert gases, and is delivered in an orderly and simultaneous manner from a specific lower tank 44 set in the downstream tank module 40 to a designated upper tank 15 in the upstream tank module 12, and through a corresponding storage container 21 in the upstream rotary module; in addition, the circular multi-valve body Ⅰ19 in the upstream rotary module is advanced by a rotating and positioning device together with a sealing mechanism. A rotation step, and then, when it is in a stationary state, the received liquid is delivered to the top of the corresponding integral unit 95 designated in the separation module.

[0596] C12: After each simultaneous delivery of various liquids in a predetermined volume sequence, the liquids are delivered intermittently by alternating the supply between two separate wide-range pressurized inert gas paths to force the dripping dosed liquid to be discharged quickly after passing through the resin to complete the expected new mass transfer equilibrium contact method between the solid phase and the liquid phase;

[0597] C13: while maintaining a closed vacuum environment, each treated liquid solution is discharged into a corresponding transfer container 38, so that the resin / adsorbent in the integral unit 95 is in a semi-dry state;

[0598] C14: Intermittently collect the discharged liquid in each transfer container 38, and transmit each collected liquid to the lower storage tank 44 through the downstream rotary module through a wide range of pressurized inert gas supply routes; the circular multi-valve body II 37 advances one rotation step in a predetermined rotation direction through a rotating and positioning device and a sealing mechanism, and then pushes all the liquid into the designated lower storage tank 44 at the same time through a wide range of pressurized inert gas supply paths.

[0599] C15: Repeat steps C11-C14, and simultaneously cover the first integral unit 95 and the second integral unit 95 receiving liquid in the separation module, until the first receiving liquid arranged in the upstream rotary module and the first receiving liquid of the transfer container 38 arranged in the downstream rotary module return to their initial positions, and one rotation cycle is completed, and the startup operation is completed;

[0600] Preferably, the various liquids recovered during the startup operation are as a specific concentrated component of at least one product in the product storage tank, and another concentrated component of at least one by-product in each by-product storage tank, a plurality of recovered mixtures, wherein a specific recovered mixture has a specific composition of components dissolved in the drain solution, and eluent held in each tank in a specific order for transfer to each corresponding upper tank 15 in the upstream tank module 12 for recovery.

[0601] like Fig.13 As shown, in order to realize the large-scale separation process, the glucose and fructose binary purification system is used again, and the startup operation of the disclosed device is performed, starting with the general procedure of the new mass transfer equilibrium contact method, as a semi-dry state resin / adsorbent installed in the fresh state separation module C, so that each sugar mixture entering through reaches an initial equilibrium state in the entire disclosed device, wherein the startup operation includes the following:

[0602] 1. By Figure 2-6The various liquid delivery routes shown above start from the predetermined volume of each upper storage tank 15 from area 0, and then, sequentially expand between areas 0, 1, 3, 4, 5, 6, 7 while the liquid input covers the next area, the feed solution, areas 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, 19, and finally the eluent water, followed by the eluent is the inert gas, and all the available liquids are simultaneously delivered to the storage container 21 set in the upstream rotary module through the pipeline, and promoted by a rotation step in a predetermined rotation direction by the rotating device and the positioning device, and then through the liquid conduit C61, as indicated, enter the top inlet of each lower integral unit 95 to perform the following mass transfer equilibrium contact process;

[0603] 2. After delivering various liquids in predetermined volumetric dosages, intermittent delivery is performed by alternately supplying pressurized inert gas between pipeline 4 30 and pipeline 3 9 to force rapid passage of each dripping liquid through the resin / adsorbent to complete the desired mass transfer equilibrium contact between the two phases;

[0604] 3. Maintain vacuum to continuously discharge the single liquid solution into the liquid reservoir 33 at the corresponding position below, and keep the resin / adsorbent in a semi-dry state;

[0605] 4, intermittently collect various processed and discharged liquids in each liquid storage tank 33, transport them to the transfer container 38 arranged in the downstream rotary module through the pipeline, advance a rotation step in the predetermined rotation direction through the rotating device and the positioning device, and then enter each designated lower storage tank 44 in the downstream storage tank module 40, and transfer the predetermined volume from the lower storage tank 44 to the designated upper storage tank 15 in the upstream storage tank module 12 through the pipeline;

[0606] 5. Repeat steps 1-4, first for zone 0, then "zone 0 and zone 1 together", until the storage container 21 in the upstream rotary module and the transfer container 38 in the downstream rotary module return to each initial position to complete a circle, so that the startup operation can be ended, wherein the various liquids recovered during the startup operation are used as "water" for the predetermined circulation, and the water with low DS glucose solution is used for other purposes, and the liquid flows of zones 0, 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17, 18 and 19 are recovered; except that the solution collected in zone 2 is glucose raffinate, and the solution in zone 15 is fructose product, such as Fig.14 in addition, all sugar mixtures except the raffinate and the product for recovery are transported from each allocated lower storage tank 44 in the downstream storage tank module 40 to each corresponding upper storage tank 15 in the upstream storage tank module 12 through a pipeline.

[0607] C2: Steady-state operating procedures during each time interval spent;

[0608] Furthermore, the content of the steady-state operation procedure includes the following steps:

[0609] C21: Through a wide range of pressurized inert gas liquid delivery methods, various liquids of predetermined volumes are delivered in various circulation flows, and all available liquids from the upper storage tank 15 are transmitted at the same time, and forced into the storage container 21 through various pressurized inert gas supply routes; at this time, the circular multi-valve body II 37 advances one rotation step in the predetermined rotation direction through the rotation and positioning device and the sealing mechanism, and then delivers the liquid to the entrance of each integral unit 95 below through a wide range of pressurized inert gas delivery methods.

[0610] Preferably, each liquid comprises its source feed solution, another plurality of recycle streams arranged in a specific order, its source eluent and a pressurized inert gas flush is introduced to remove the remaining liquid.

[0611] C22: After delivering various liquids to each integral unit 95 below, intermittent delivery is performed by alternating supply between two separate wide range pressurized inert gas paths to force the dripping dosage liquid to be discharged after passing through the resin / adsorbent quickly to complete the expected new mass transfer contact equilibrium method between the solid phase and the liquid phase;

[0612] C23: while maintaining a closed vacuum environment, each treated liquid solution is discharged into a corresponding transfer container 38, so that the resin / adsorbent disposed in each integral unit 95 is in a semi-dry state;

[0613] C24: Collect various discharged liquids in each transfer container 38, and transfer the collected liquids to the lower storage tank 44 through the downstream rotary module via a wide range of pressurized inert gas supply routes; the circular multi-valve body II 37 advances one rotation step in a predetermined rotation direction through a rotating and positioning device and a sealing mechanism, and then pushes all the liquids into the designated lower storage tank 44 at the same time through a wide range of pressurized inert gas supply paths.

[0614] Preferably, the various liquids recovered during steady-state operation are as a specific concentrated component of at least one product in each product storage tank, and another concentrated component of at least one by-product in each by-product storage tank, various recovered mixtures [a specific recovered mixture in the mixture has a specific combination of said components dissolved in the discharged solution], and eluent held in each storage tank in a specific order for transfer to each corresponding upper storage tank 15 in the upstream storage tank module 12 for recovery.

[0615] Once the startup operation is complete, the disclosed apparatus can then transition to steady-state operation. Figure 2-6 Liquid delivery method, through Fig.14 All types of liquids in all area settings are arranged, such as Fig.13 This is shown in relation to the separation of the sugar mixture that meets the requirements. During the predetermined time spent in each area, multiple storage containers 21 simultaneously receive all available predetermined amounts of various liquid delivery and simultaneously transfer them to the designated integrated units, and a new mass transfer equilibrium contact method is performed in the separation module to obtain each processed sugar mixture from the bottom of the respective integrated unit 95 as a steady-state operation. The same process is repeated, as follows for steady-state operation:

[0616] 1-Through the above Figure 2-6 The various predetermined volume liquid delivery paths shown, from area 0, 1, 3, 4, 5, 6, area 7, feed liquid, area 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, 19, elution water, and finally after the inert gas is put into the elution water, all the available liquid is delivered to the storage container 21 through the pipeline; promoted by a rotation step in a predetermined rotation direction through the rotating device and the positioning device, and then enter the top inlet of each lower integral unit 95 through the pipeline as indicated, to perform the following mass transfer equilibrium contact process;

[0617] 2- after delivering each liquid in a dose of a predetermined volume, intermittently delivering a dose of a predetermined volume by alternately supplying a pressurized inert gas between the pipe 30 and the pipe 9 to force the rapid passage of each dripping liquid through the resin / adsorbent to complete the desired mass transfer equilibrium contact between the two phases;

[0618] 3-Maintain vacuum to continuously discharge the single liquid solution into the temporary liquid storage tank 33 at the corresponding position below, and keep the resin / adsorbent in a semi-dry state;

[0619] 4- Intermittently collect various processed and discharged liquids in each temporary liquid storage tank 33; synchronously transport them to the transfer container 38 through a pipeline; synchronously advance a rotation step in a predetermined rotation direction through a rotating device and a positioning device, and then synchronously enter each designated lower storage tank 44 in the downstream storage tank module 40, and synchronously transfer a predetermined volume from the lower storage tank 44 to the designated upper storage tank 15 in the upstream storage tank module 12 through a pipeline; wherein all liquids are recovered as "water" for predetermined purposes, low DS glucose aqueous solution for other purposes, and recovered liquid flows of areas 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 and area 19; wherein the solution collected from area 2 is glucose raffinate, and the solution collected from area 15 is fructose product;

[0620] 5- As Figure 2 As shown, all of the sugar mixture except the raffinate and the product is further transferred for recovery from each lower storage tank 44 in the downstream storage tank module 40 to each corresponding designated upper storage tank 15 in the upstream storage tank module 12 through pipeline distribution.

[0621] Therein, an aqueous feed solution is introduced from its source through line 47 located between the circulation streams of zones 7 and 8, wherein the glucose content of the feed solution is slightly lower than that of zone 7 and slightly higher than that of zone 8. Therefore, the glucose and fructose components initially contained in the feed solution migrate horizontally through the circulation stream to a pure glucose raffinate stream recovered as zone 2 through line 77, and to a pure fructose product stream recovered as zone 15 through line 78. In addition, conventional chromatography requires extra time to travel with a large amount of liquid flow to the displacement zone where the separation of components is performed. The present invention has demonstrated the elimination of Figure 1 Such displacement zone 89 as described in the above, thus the cycle time is greatly reduced to 4 minutes, and therefore the resin / adsorbent inventory, eluent water consumption and other unspecified operating costs can be reduced proportionally. Similarly, the introduction of the binary feed solution between the recovery streams of zones 7 and 8 was determined mainly because the single column test results concluded that this differential setup and single stage recovery scheme adopted by the disclosed parameter differential moving bed (PDMB) is the main difference between the chromatography operation and the widely adopted simulated moving bed (SMB) process. In fact, the characteristic elution curve obtained by the general procedure of the new mass transfer equilibrium contact method single column test itself points out that this high fructose corn syrup (HFCS) separation requires a very long and narrow column in the chromatography operation, which is not possible for very long and narrow columns because of the high pressure drop, the need to install rigid resin / adsorbent to withstand such pressure and various concurrent fluid dynamic problems such as diffusion / mixing and column boundary effects, which are solved by the hybrid PDMB of the present invention.

[0622] C3: Restoring to a fresh semi-dry state in a parameter differential moving bed for termination operation;

[0623] Preferably, the termination operation is a reverse operation sequence for generating a start-up operation of the resin / adsorbent installed in the separation module;

[0624] Furthermore, the specific content of the termination operation includes the following supplements:

[0625] C31: the integral unit 95 located at the first position in the separation module stops receiving the predetermined volume of liquid delivery, while the remaining integral units 95 continue to receive the liquid at the same time;

[0626] In addition, predetermined volumes of various liquids arranged in a specific order in various recycling streams are delivered from their sources, and another plurality of circulating streams are arranged in a specific order, and then the eluent is delivered from its source, and finally flushed with an inert gas to discharge the remaining liquid. All of the above liquids are delivered in connection with the supply of a wide range of pressurized inert gases, and are delivered in an orderly and simultaneous manner from a specific lower tank 44 of the downstream tank module 40 to a specific upper tank 15 in the upstream tank module 12, and through a specific storage container 21 in the upstream rotary module; in addition, the circular multi-valve body Ⅰ19 in the upstream rotary module is advanced by a rotation step together with the sealing mechanism through a rotation and positioning device, and then delivers the received liquid to the top of the corresponding integral unit 95 designated in the separation module while it is in a stationary state.

[0627] C32: After each simultaneous delivery of various liquids in a predetermined volume sequence, the liquids are delivered intermittently by alternating the supply between two separate wide-range pressurized inert gas paths to force the dripping dosed liquid to be discharged quickly after passing through the resin to complete the expected new mass transfer equilibrium contact method between the solid phase and the liquid phase;

[0628] C33: while maintaining a closed vacuum environment, the treated liquid solution is discharged into the corresponding transfer container 38, so that the resin / adsorbent in the integral unit 95 is in a semi-dry state;

[0629] C34: Collect the discharged liquid in each transfer container 38, and transmit each collected liquid to the lower storage tank 44 through the downstream rotary module through a wide range of pressurized inert gas supply routes; the circular multi-valve body II37 advances one rotation step in the predetermined rotation direction through the rotation and positioning device and the sealing mechanism, and then pushes all the liquid into the designated lower storage tank 44 at the same time through a wide range of pressurized inert gas supply paths.

[0630] C35: Repeat steps C31-C34, and simultaneously cover the first integral unit 95 and the second integral unit 95 for receiving liquid in the separation module to stop receiving liquid, until the first receiving liquid arranged in the upstream spin-on module and the first receiving liquid arranged in the transfer container 38 of the downstream spin-on module return to their initial positions, completing one cycle, and then completing the termination operation; so as to produce the installed resin / adsorbent back to the initial fresh semi-dry state arranged in the parameter differential moving bed.

[0631] In order to restore the resin / adsorbent in the separation module to a fresh semi-dry state in the device, the termination operation is:

[0632] 1. By Figure 2-6The various liquid delivery routes shown above, starting from area 0, stop delivering a predetermined volume of various liquids from the respective upper storage tanks 15, but still provide simultaneous liquid input covering the next area in sequence between areas 0, 1, 3, 4, 5, 6, 7, feed solution, 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, 19, eluent water, and finally the inert gas after elution of water, and all available liquids are simultaneously delivered to the storage container 21 set in the upstream rotary module through the pipeline; promoted by a rotation step in a predetermined rotation direction through the rotating and positioning device and the sealing mechanism, and then enter the inlet at the top of each lower integral unit 95 through the pipeline as indicated, so as to carry out a conventional mass transfer equilibrium contact process;

[0633] 2. After delivering each liquid in a predetermined volume dose, intermittently deliver a predetermined volume dose by alternately supplying pressurized inert gas between pipeline 29 30 and pipeline 3 9 to force the dripping liquid to be rapidly discharged through each resin / adsorbent to complete the desired mass transfer equilibrium contact between the two phases;

[0634] 3. Maintain vacuum to continuously discharge the single liquid solution into the liquid reservoir 33 at the corresponding position below, and keep the resin / adsorbent in a semi-dry state;

[0635] 4. Intermittently collect various processed and discharged liquids in each liquid storage tank 33, and synchronously transport them to the transfer container 38 through the pipeline 59; synchronously advance a rotation step in a predetermined rotation direction through the rotating device and the positioning device, and then synchronously enter each designated lower storage tank 44 in the downstream storage tank module 40, and synchronously transfer the predetermined volume from the lower storage tank 44 to the designated upper storage tank 15 in the upstream storage tank module 12 through the pipeline;

[0636] 5. Repeat steps 1-4, first stop transmitting liquid to zone 0, then "zone 0 together with zone 1", until the storage container 21 in the upstream spin-on module and the transfer container 38 in the downstream spin-on module return to each initial position to complete a circle. In this way, the termination stage operation can be ended and the installed resin / adsorbent can be produced back to the initial fresh semi-dry state.

[0637] Further, in the single-stage recovery procedure, the wide range of pressure levels of the pressurized inert gas is 40-90 psi, wherein the low range of pressure levels of the pressurized inert gas is 40-55 psi, the medium range of pressure levels of the pressurized inert gas is 55-70 psi, and the high range of pressure levels of the pressurized inert gas is 75-90 psi.

[0638] Fig.10 In the liquid input format, it can be Fig. 9The isocratic elution 85 input SI shown in the upper part or the discrete isocratic elution 85 input II shown in the lower part, the input SI only distinguishes the predetermined volume of the same mobile phase parameter 85, which means that it is differentiated into partial volumes with multiple liquid doses within the minimum time interval to maximize the mass transfer equilibrium contact efficiency. Input II distinguishes the partial input volume of multiple liquid doses at a predetermined slope and distinguishes the mobile phase conditions in a discrete format according to each minimum time interval. Each partial input volume is a discrete increment where the mobile phase condition falls between two adjacent running conditions, and each corresponding step input number avoids co-elution of two adjacent elution peaks. A single-stage recovery scheme is further illustrated for increasing the solution concentration level of multiple separation peaks including product A in #3 and others, and minimizing the consumption of solutions with mobile phase parameters #1, #2 and #4. Depending on the requirements of the specific target system, solutions #2 and #4 can be selected to continue to be recycled to the same upper storage tank 15 through the recovery route of their predetermined liquid distribution loop, or be discarded if the operating conditions of this parameter become weak, or their operating conditions are adjusted for other uses; where #1 can continue to be recycled or mixed with the feed solution for use in the feed zone 20.

[0639] The results show that: during steady-state operation, various liquids are simultaneously delivered to the corresponding areas, thereby converting the traditional chromatographic separation path from parallel to vertical in the flow direction of the mobile phase; at any time interval of steady-state operation, through the elution results of single column test, a complete separation cycle is completed after each expenditure of the minimum time interval for all areas to achieve Figure 1 The main objectives of the parameter differential moving bed (PDMB) are briefly described.

[0640] Then from Fig.11It can be understood that the elution curve is an isocratic elution input SI mode with a format of 85, starting from the mobile phase parameter solution #1 (feed condition), through #2, #3, #4, #5 to the final mobile phase #6, a total of 5 peaks are generated. After the loading feed is completed, the differential speed between the two phases in the feed zone 20 is set by the same previous diagram to obtain the maximum adsorption efficiency and is selected as the most time-consuming area. The conditions of all subsequent eluents are derived and predetermined by early isopoint belief teaching. The parameter solution #2 condition has been preset before the isopoint of the desired product A1 so that all impurities will be classified because B1 will elute before product A1. This includes the first impurity stripping step performed in the first impurity stripping zone 21. The conditions of the #3 mobile phase are just to elute the desired product A1 before the isopoint of the impurity group B2. This includes the first product recovery step performed in the first product recovery zone 22. Enter the #4 condition to cover the elution of impurity B2 as the second impurity stripping step performed in the second impurity stripping zone 23. #5 conditions are entered to cover the elution of the desired product A2 before the isopoint of the impurity group B3, including the second product recovery performed in the second product recovery zone 24. #6 conditions are used to cover the elution of the third impurity step performed in the third impurity stripping zone 25. Finally, a washing / sanitizing step is performed in the washing zone 26 by recovering the #1 mobile phase collected from the feed zone to prepare for the re-feed of the resin / adsorbent;

[0641] Input II is carried out by starting with a loading feed step to obtain maximum adsorption efficiency in the #1 mobile phase feed zone 20. The first impurity stripping step is carried out in the first impurity stripping zone 21 in the form of small discrete increments of mobile phase parameters, starting with #1 and ending with #2, to maximize the elution of B1 and avoid co-elution with product A1, through input I-I85. The first product recovery step is carried out in the first product recovery zone 22, input I-I85 starts with #2 and ends with #3, to maximize the elution of product A1 and avoid co-elution of the second impurity B2. In the second impurity stripping zone 23, the second impurity stripping step is carried out by starting with #3 and ending with #4 through input II, to maximize the elution of the second impurity group B2 and avoid co-elution of the second product A2. The second product recovery step is carried out in the second product recovery zone 24, input II starts with #4 and ends with #5, to maximize the elution of product A2 and avoid co-elution of the third impurity B3. Since product A2 is eluted, a regeneration step is performed in regeneration zone 25 by inputting S-I85#6 mobile phase to remove the third impurity group B3. Generally, an increment of the mobile phase parameter by a small interval Δt is sufficient. Similarly, the slope of this imaginary point line depends entirely on the design preference of the target separation system; both require experimental verification of the target separation system. Finally, a washing / sterilization step is performed in washing zone 26 by recovering #1 mobile phase from zone 20 and inputting S-I85 to prepare the resin / adsorbent for the re-feed adsorption step in feed zone 20.

[0642] at last Fig.12 An example is shown of the accumulation of 36 minimum time intervals Δt applied on the device by the differential setup procedure for the feed solution #1, #2, #3, #4, #5, #6 and #1 with the mobile phase parameters simultaneously entered in the selected input SI or II mode, similar to Fig.11 . Based on a single minimum time interval Δt for each expenditure, and accumulated in order during each time interval of expenditure to complete Fig.12 The profile derived in . And further illustrates a single-stage recovery scheme for increasing the concentration level of the separated peaks, including the first product A1 in solution #3 and the second product A2 in solution #5, and minimizing the consumption of solutions of mobile phase parameters #1, #2, #4 and #6. According to the requirements of the specific target system, solutions #2, #4 and #6 can be selected to continue to be recovered back to the same upper storage tank 15 through their predetermined liquid distribution loop routes or discarded if the operating conditions of the parameter become weak, or their operating conditions are adjusted for other uses; among them, #1 can continue to be recovered or mixed with the feed solution for use in the feed zone 20. From the single column study, it means Fig.11The elution curve shown represents a mass transfer phenomenon / equilibrium state achieved in multiple steps in sequence, but in fact multiple mass transfer equilibrium contacts are carried out simultaneously through the disclosed device, wherein mass transfer equilibrium contacts are carried out between specific mixtures of mobile phase parameter solutions entering from the top of each integral unit 95 and quickly passing through the resin / adsorbent bed to achieve the desired separation.

[0643] pass Fig. 9 and Fig.11 The elution results for the single column test shown here are for a complete separation cycle of all zones after each minimum time interval Δt to achieve Figure 1 The main objectives of the parameter differential moving bed (PDMB) are briefly described.

[0644] Figure 10-12 The above-mentioned single-stage recovery scheme is elaborated in detail in , and during the steady-state operation adopted by the device, various liquids are delivered to their respective zones simultaneously, through which the traditional chromatographic separation path is converted from parallel to the flow direction of the mobile phase to perpendicular.

[0645] The general procedure of the new mass transfer equilibrium contact method is as follows: the mobile phase liquid material is sequentially transported through a predetermined type of liquid distributor, and the shower head 29 conducts a predetermined volume of the transport fluid to sprinkle into the wetted area of ​​the resin / adsorbent in a short time, thereby achieving the expected new mass transfer equilibrium contact method between the two phases; the mobile phase liquid material is partially transported through a predetermined type of liquid distributor, so that a predetermined volume of the transport fluid splashes like a downward umbrella in a short time, and this splashing fluid hits the inner wall of the integral unit 95 and quickly slides downward to partially lift upward and penetrate into the resin / adsorbent particles contained in the upward stirring, and this instantaneous partial mixing effect is for rapid contact to significantly reduce the time required for the expected new mass transfer equilibrium contact method between the two phases.

[0646] The heat medium in the insulating jacket 11, the interlayer jacket 36 and the hollow jacket 41 is water at a temperature of 0-100°C, wherein brine or a mixture of water and antifreeze is used for lower temperatures below 0°C; mineral oil and other synthetic heat carriers are used for temperatures above 100°C.

[0647] When this embodiment is used, each module in the PDMB of the present invention operates independently and is coordinated in sequence to achieve the continuous separation of the purified at least one component as a product from the component mixture dissolved in a specific uniform feed solution. During each time interval of steady-state operation, all kinds of liquid solutions are simultaneously distributed from each upper storage tank 15 in the upstream storage tank module 12 through each storage container 21 in the upstream rotary module, and are intermittently transferred to the corresponding integral unit 95 in the separation module for mass transfer equilibrium contact; then the treated liquid collected in each liquid reservoir 33 is transferred to each allocated lower storage tank 44 in the downstream storage tank module 40 through each transfer container 38 in the downstream rotary module, and then circulated back to the closed loop of the upstream storage tank module 12 through the downstream storage tank module 40, and continuously separated in the form of new mass transfer equilibrium contact, and the separation of the specific target separation mixture is achieved in a repeated manner, and the whole process is carried out by controlling various pressurized inert gases combined with the above modules to achieve the final separation of the large-scale production separation system.

[0648] The present invention integrates all stages into a complete separation cycle by continuous operation of simultaneous feeding, impurity stripping, adsorbent regeneration, washing and / or sanitation, etc., to simultaneously separate at least one product stream and stripping, regeneration, and washing of multiple impurities. The PDMB of the present invention can also be used in a binary separation system in the separation process of glucose and fructose, reducing the consumption of water washing liquid and reducing the final power consumption.

[0649] The present invention implements a new mass transfer equilibrium contact method, adopts a differential setting procedure between the two phases, switches the adsorbent and the mobile phase to fully use the adsorbent, thereby obtaining the maximum mass transfer efficiency between the two phases, and realizes a significant reduction in the resin / adsorbent inventory set in the device. The solid phase simulated to move in the horizontal direction is continuously and uniformly exposed to contact with multiple mobile phases in the vertical direction at the same time, and the elution curve of the specific separation system is organized along the horizontal direction of the device to receive the mobile phase transmitted in the vertical direction to simultaneously achieve a complete separation cycle within the duration of each time taking the shortest time interval.

[0650] The present invention provides a new mobile phase input format to distinguish from chromatographic separation, such as general parameters such as pH value, polarity or ionic strength related to solubility, etc., wherein the input SI format is defined as a plurality of predetermined input volumes of the same mobile phase parameter condition being delivered simultaneously and intermittently in sequence to each integral unit 95 set in a specific defined area within the duration of the minimum time interval; and the input II format is defined as a plurality of predetermined volumes of mobile phase parameter condition solutions being delivered simultaneously and intermittently in sequence to each integral unit 95 located in the same specific defined area within the duration of the minimum time interval. The difference increment of each mobile phase condition is between two pre-specified levels, which are grouped with each unit in the area accordingly, and the input volume of each discrete mobile phase parameter condition is further divided into predetermined equal parts, and is therefore also associated with a specified unit in the area.

[0651] The single-stage recovery scheme provided by the present invention utilizes the elution curve arranged in an endless form to simultaneously separate and improve the concentration level of the separation fraction of the target separation system, thereby reducing the consumption of the mobile phase.

[0652] The present invention expands the chemical unit operations constituting similar mass transfer phenomena to other chemical units by combining and applying differential settings, new mass transfer equilibrium contact methods, operating procedures and parameter differential moving beds, and applies them such as catalytic reactions in reaction towers, activated carbon leaching beds for decolorization or deodorization, and fluidized solid-liquid reactions.

[0653] The present invention provides a preferential operating procedure including at least one operation of a startup phase, a steady-state phase, and a termination phase to achieve separation with the disclosed apparatus by coordinating a new mass transfer equilibrium contact method and a differential setup.

[0654] Embodiment 2:

[0655] A parametric differential separation process, such as Figure 1-20 As shown, the new mass transfer equilibrium contact method is used to organize the differential setting procedure as follows:

[0656] 1. By gradually adding and mixing the resin / adsorbent in a semi-dry state into a feed liquid volume 93 containing solute components in a predetermined volume to obtain a saturated solid phase volume 94, thereby promoting at least one or all solute components to be adsorbed onto the added resin / adsorbent amount;

[0657] 2. Place a certain amount of solid phase resin / adsorbent in a semi-dry state into the integral unit 95;

[0658] Preferably, the amount of solid phase resin / adsorbent corresponds to the mass transfer zone 88 defined previously and is the saturated amount of resin / adsorbent in the feed zone 20 and corresponds to the feed solution volume throughput predetermined in the chromatography operation to saturate...

Claims

1. A parameter differential separation process, characterized in that: The steps include: S1: Use parametric differential moving bed as generalized separation process, operate generalized separation process to eliminate displacement zone in chromatographic sequential operation; S2: The mobile phase liquid feed solution is contacted with the solid phase resin / adsorbent filler by a new mass transfer equilibrium contact method to begin to obtain a characteristic separation curve; S3: separating the multiple components contained in the mobile phase liquid feed solution by a new mass transfer equilibrium contact method, so that at least one component contained in the mobile phase liquid feed solution can be adsorbed onto the resin / adsorbent; S4: transporting various liquid solutions of at least a second and a third mobile phase by a new mass transfer equilibrium contact method; The generalized separation process is to convert the flow direction of the mobile phase of the chromatographic mass transfer mechanism from a parallel path to a perpendicular path with the placed solid phase, specifically: using a generalized separation process to simultaneously introduce each integral unit (95) containing a specific resin / adsorbent filler into a corresponding mobile phase to eliminate the displacement zone in the chromatographic sequential operation, and the specific operation content of eliminating the displacement zone is: introducing various liquid solutions in the sequential operation, first by optimizing the same predetermined mobile phase parameters and resin / adsorbent filler as a predetermined combination to generate an acceptable elution curve of the target separation system to be performed in a typical chromatographic separation; The S2 step includes determining the flux of the mobile phase liquid feed solution and the solid phase amount of the resin / adsorbent for the optimal full-strength adsorption capacity; The content of the step S3 is specifically as follows: dissolving at least one circulating liquid stream having a specific solute composition in a predetermined eluent solution mixture with modified characteristic parameters by a new mass transfer equilibrium contact method to elute a specific adsorbed solute component; all circulating liquid streams are arranged in sequence and contacted with resin / adsorbent to separate at least one desired component migrating through various circulating streams; The liquid solution comprises a predetermined composition that is contacted with a solid phase resin / adsorbent filler; The resin / adsorbent is a granular material, and the granular material is one of a granular ion exchange resin / adsorbent, a granular ligand exchange resin / adsorbent, a granular reverse phase resin / adsorbent, a granular affinity resin / adsorbent, a granular normal phase resin / adsorbent, a granular activated carbon and a granular catalyst; The parametric differential moving bed is operated by a differential setting procedure and a single-stage recovery procedure, which is a general procedure of a new mass transfer equilibrium contact method between a solid and a mobile phase, including the following mixed examples: A1-New mass transfer equilibrium contact method; A2-New mass transfer equilibrium contact method obtains the characteristic separation curve of a specific separation system by keeping the resin / adsorbent solid phase in a semi-dry state as the optimal full-strength adsorption capacity in contact with the mobile phase liquid feed solution volume; The A3-parameter differential moving bed comprises an upstream storage tank module (12), an upstream rotary connection module, a separation module, a downstream rotary connection module, a downstream storage tank module (40) and an inert gas supply module, wherein the upstream rotary connection module serves as a bridge between the upstream storage tank module (12) and the separation module, the downstream rotary connection module serves as a bridge between the bottom of the separation module and the downstream storage tank module (40), and the inert gas supply module is a transmission mechanism submodule for the mobile phase liquid flow and integrated with the separation module; the upstream storage tank module (12), the upstream rotary connection module, the separation module, the downstream rotary connection module, the downstream storage tank module (40) and the inert gas supply module are operated in parallel; A4-Generalized separation process by the differential setting program scheme adopted by the general procedure of the new mass transfer equilibrium contact method: adopting a predetermined matching mobile phase input mode selected between SI mode and II mode to obtain a characteristic separation curve of a specific separation system associated with the selected resin / adsorbent solid phase and combining various mobile phase liquid solutions into a parameter differential moving bed for separating at least one desired component from the liquid solution mixture continuously and simultaneously within each minimum time interval spent; A5-The general separation process adopts a single-stage recovery program scheme on a parameter differential moving bed through a new mass transfer equilibrium contact method: through a mobile phase liquid flow transmission mechanism together with each module arranged in the parameter differential moving bed, each mobile phase liquid flow originally stored in the corresponding upper storage tank (15) arranged in the upstream storage tank module (12) is simultaneously and intermittently transported to the separation module for the expected new mass transfer equilibrium contact method.

2. A parameter differential separation process according to claim 1, characterized in that: The monolithic unit (95) is used to separate a specific solute mixture containing at least one desired component from at least one other component into a limited composition, a homogeneous liquid solution mixture containing the solute mixture as a feed solution mobile phase, interacting with a resin / adsorbent particulate material and multiple dissolved components in the mobile phase stream to promote adsorption, a new mass transfer equilibrium contact method between the two phases; The feed solution mobile phase is a solute component of a mixture of oligosaccharides, glucose and fructose, which is used to continuously and simultaneously separate at least one desired component from a liquid solution mixture containing one component and at least another component, and includes a component percentage composition and dry solids uniformly dissolved in deionized, foul-free water; the solute component has a limited component percentage composition and a limited dry solids concentration dissolved in a limited volume of deionized, foul-free eluent water to promote adsorption of at least one component onto a resin / adsorbent, and each circulating flow contains a solute composition dissolved in a predetermined limited solute percentage composition, an eluent solution mixture and an eluent solution. The stripping liquid is the same deionized non-polluted water, and includes a feed solution mobile phase with multiple circulating streams and eluents, which simultaneously and intermittently pass rapidly through at least one integral unit (95) to achieve the expected new mass transfer equilibrium contact method, separating at least one component from at least one other component to obtain a concentrated dry solid concentration and gradually separated glucose and fructose components, wherein the resin / adsorbent is orderly arranged in at least one integral unit (95) of the device, and the resin / adsorbent is an alkaline earth metal base strong acid cation exchanger in particles, and the alkaline earth metal base strong acid cation exchanger is a calcium base strong acid cation exchanger.

3. A parameter differential separation process according to claim 2, characterized in that: The resin / adsorbent fillers include ion exchange, affinity, reverse phase, normal phase, ligand exchange, granular activated carbon, and catalysts.

4. A parameter differential separation process according to claim 3, characterized in that: The resin / adsorbent interacts with multiple dissolved components in the mobile phase flow to promote new mass transfer equilibrium contacts, including the following: S31: In the first mobile phase zone of the upstream storage tank module (12), at least one of the first mobile phase flows contained in the upper storage tank (15) is a new mass transfer equilibrium contact method that promotes adsorption, that is, the feed solution and the dissolved components are arranged in the first mobile phase zone, i.e., the feed zone; and at least one corresponding lower storage tank (44) arranged in the downstream storage tank module (40) is used to receive and contain the liquid discharged from the first mobile phase and transport it to the last mobile phase zone, i.e., the washing zone; S32: In the second mobile phase zone of the upstream storage tank module (12), at least one of the second mobile phase flows contained therein is an adsorbed component eluted with at least one of the second mobile solutions of at least one impurity stripping zone; and at least one corresponding lower storage tank (44) disposed in the downstream storage tank module (40) is used to receive and contain liquid discharged from the corresponding second mobile phase; S33: In the third mobile phase zone of the upstream storage tank module (12), at least one of the third mobile phase flows contained therein is eluted with at least one adsorbed component in at least one third mobile solution of the product recovery zone; and at least one corresponding lower storage tank (44) is arranged in the downstream storage tank module (40) to receive and contain the liquid discharged by the corresponding third mobile phase, and at least one recovered product after elution is to increase the corresponding concentration level of the eluted product and return to the designated upper storage tank (15) of the at least one product recovery zone as a recovery flow; S34: In the fourth and fifth mobile phase zones of the upstream storage tank module (12), at least one of the fourth and fifth mobile phase flows contained therein is further eluted with at least one regeneration zone and additional zone of at least the fourth and fifth mobile phase solutions in sequence with at least one adsorbed component; and at least one corresponding lower storage tank (44) is arranged in the downstream storage tank module (40) to receive and hold the liquid discharged from the fourth and fifth mobile phases corresponding to at least one component eluted, so as to increase the concentration level of each recovered component, and return it to the designated upper storage tank (15) as a circulating flow, corresponding to at least one regeneration zone and additional zone; S35: In the washing area of ​​the upstream storage tank module (12), at least one first mobile phase flow contained in each upper storage tank (15) is transported to clean and wash off the installed resin / adsorbent solid filler; and at least one corresponding lower storage tank (44) arranged in the downstream storage tank module (40) is used to receive and contain the liquid discharged by the first mobile phase, adjust and mix it with the components in the feed solution, and return it to the designated upper storage tank (15) in the feed area as a recovery flow.

5. A parameter differential separation process according to claim 4, characterized in that: The new mass transfer equilibrium contact method in A1 comprises the following steps: i) retaining a predetermined amount of solid phase resin / adsorbent uniformly distributed in a predetermined number of chromatographic single columns (23) so that the bundled column group acts as an integral unit (95); ii) intermittently delivering a predetermined amount of mobile phase liquid material to the integrated unit (95) through a predetermined type of liquid distributor to contact the resin / adsorbent within a predetermined first time period; iii) during a predetermined second time period, after each delivery of the mobile phase liquid material, intermittently supplying a wide range of pressurized inert gas to the top of the integral unit (95); Wherein, step iii) further comprises providing a vacuum environment from the bottom of the integral unit (95) to the other side of the installed solid phase material; wherein step iii) further comprises collecting a majority of the processed mobile phase liquid material from the outlet at the bottom of the integral unit (95), and repeating steps ii) to iii) until a predetermined sequence of the plurality of liquid solutions is satisfied; Wherein, the total time taken for steps ii) to iii) is the minimum time interval Δt; Each single column (23) in the integrated unit (95) retains an equal amount of resin / adsorbent material; The mobile phase liquid material includes a predetermined composition of various liquid solutions of predetermined composition in at least the second and third mobile phases including the mobile phase liquid feed solution, and at least one circulating liquid flow is organized in sequence.

6. A parameter differential separation process according to claim 5, characterized in that: A2, a method for separating a plurality of components contained in at least one first mobile phase flow in a liquid solution containing the components by sequentially contacting the solid phase resin / adsorbent with at least one mobile phase liquid feed solution, wherein at least one of the components is adsorbed by the resin / adsorbent; The first mobile phase flows and is consumed in the minimum time interval for the feed zone.

7. A parameter differential separation process according to claim 6, characterized in that: The liquid input format delivered by the liquid dispenser includes SI mode and II mode, wherein the duration of the input SI mode along the time domain is that during each time period of the minimum time interval, a predetermined amount of solution with the same mobile phase parameter condition is delivered into the integral unit (95) through a predetermined type of liquid dispenser; in addition, the input II mode is that discrete increments of a predetermined amount of mobile phase parameter condition liquid are delivered in the time domain in a sequence of duration within the minimum time interval, and enter the integral unit (95) through a predetermined type of liquid dispenser; various characteristic parameters are selected as mobile phase conditions of the homogeneous liquid solution, including pH value, ionic strength, solubility, polarity, which are named after a wide spectrum of changes, and combined with the selected resin / adsorbent filler, it is a combined selection of intermittent operation mode, that is, various liquid solutions are introduced in sequential operation; The option of entering SI mode obtains a characteristic separation curve by delivering the mobile phase as follows: A201: intermittently delivering a predetermined amount of at least one of a plurality of first mobile phase flows to an inlet of the integral unit (95) within a predetermined first time period; A202: During a predetermined second time period, after each delivery of the first mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit (95) so as to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit (95), and at the same time, a vacuum environment is maintained on the other side of the integral unit (95) where the solid phase material is installed during the predetermined second time period so as to keep the resin / adsorbent material in a semi-dry state; A203: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit (95); A204: Define the total time spent in steps A201-A203 as the minimum time interval; A205: repeating step A204 until all at least one first mobile phase flow is sequentially delivered and the total cumulative minimum time interval is the first mobile phase zone, and then after a predetermined amount of the first mobile phase flow is intermittently delivered, the resin / adsorbent is further sequentially contacted with at least one second mobile phase flow to achieve a desired new mass transfer equilibrium contact method, so that at least one component is sequentially desorbed separately from the resin / adsorbent; A206: intermittently delivering multiple amounts of at least one predetermined amount of the second mobile phase flow to the inlet of the integral unit (95) during a predetermined first time period; A207: During a predetermined second time period, after each delivery of the second mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit (95) so as to rapidly push the delivered second mobile phase through the resin / adsorbent installed in the integral unit (95), and at the same time, a vacuum environment is maintained on the other side of the integral unit (95) where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state; A208: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit (95); A209: Define the total time spent in steps A206-A208 as the minimum time interval; A210: repeating step A209 until all at least one second mobile phase flow is sequentially delivered and the total cumulative minimum time interval is the second mobile phase zone, and then after a predetermined amount of the second mobile phase flow is intermittently delivered, the resin / adsorbent is further sequentially contacted with at least one third mobile phase flow to achieve a desired new mass transfer equilibrium contact method, so that at least one component is sequentially desorbed separately from the resin / adsorbent; A211: intermittently delivering multiple amounts of at least one predetermined amount of the third mobile phase flow to the inlet of the integral unit (95) during a predetermined first time period; A212: During a predetermined second time period, after each delivery of the third mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit (95) so as to rapidly push the delivered third mobile phase through the resin / adsorbent installed in the integral unit (95), and at the same time, a vacuum environment is maintained on the other side of the integral unit (95) where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state; A213: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit (95); A214: Define the total time spent in steps A211-A213 as the minimum time interval; A215: repeating step A214 until all at least one third mobile phase flow is delivered in sequence and the total cumulative minimum time interval is the third mobile phase zone, if the remaining components are still adsorbed by the resin / adsorbent, repeating step A215 by adding at least one fourth mobile phase flow so that the components can be eluted by a predetermined composition to achieve the expected new mass transfer equilibrium contact method, so that the remaining components are sequentially desorbed from the resin / adsorbent separately, if the remaining components are not adsorbed by the resin / adsorbent, proceeding to step A216; A216: intermittently delivering a predetermined amount of at least one of the discharged and collected first mobile phase flows to the inlet of the integrated unit (95) during a predetermined first time period in step A203; A217: During a predetermined second time period, after each delivery of the first mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit (95) so as to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit (95), and at the same time, a vacuum environment is maintained on the other side of the integral unit (95) where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state; A218: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit (95); A219: Define the total time spent in steps A216-A218 as the minimum time interval; A220: repeating step A219 until at least one of all first mobile phase streams is delivered in sequence and the total cumulative minimum time interval is the last mobile phase zone; A221: Finally, all defined regions are integrated in turn according to the mobile phase parameter conditions in the time domain, thereby obtaining the characteristic separation curve of a specific separation system by inputting the SI mode.

8. A parameter differential separation process according to claim 7, characterized in that: The Input II mode option obtains a characteristic separation curve by delivering the mobile phase as follows: A251: intermittently delivering a predetermined amount of at least one of the first mobile phase flows to the inlet of the integral unit (95) during a predetermined first time period; A252: During a predetermined second time period, after each delivery of the first mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit (95) so as to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit (95), and at the same time, a vacuum environment is maintained on the other side of the integral unit (95) where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state; A253: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit (95); A254: The total time spent in steps A251-A253 is defined as the minimum time interval, also known as the first discrete mobile phase region; A255: repeating step A254, by increasing the discrete increments of the mobile phase parameter conditions until all adjusted at least one first mobile phase flow is sequentially delivered with a preset incremental discrete and total cumulative minimum time interval being a plurality of first discrete mobile phase zones, which are sequentially named corresponding to the mobile phase parameter conditions delivered respectively, and then after the parameter conditions of the first mobile phase flow are intermittently delivered in a predetermined amount of discrete increments, the resin / adsorbent is sequentially contacted with at least one second mobile phase flow, and a desired new mass transfer equilibrium contact method is achieved with the discrete incremental parameter conditions, so that at least one component is sequentially desorbed separately from the resin / adsorbent; A256: intermittently delivering multiple amounts of at least one predetermined amount of the second mobile phase flow to the inlet of the integral unit (95) during a predetermined first time period; A257: During a predetermined second time period, after each delivery of the second mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit (95) to rapidly push the delivered second mobile phase through the resin / adsorbent installed in the integral unit (95), and at the same time, a vacuum environment is maintained on the other side of the integral unit (95) where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state; A258: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit (95); A259: The total time spent in steps A256-A258 is defined as the minimum time interval, also known as the second discrete mobile phase region; A260: repeating step A259 by increasing the discrete increments of the mobile phase parameter conditions until all adjusted at least one second mobile phase flow is sequentially delivered with a preset increment discrete and total cumulative minimum time interval being a plurality of second discrete mobile phase zones, which are sequentially named corresponding to the mobile phase parameter conditions delivered respectively, and then after the parameter conditions of the second mobile phase flow are intermittently delivered in a predetermined amount of discrete increments, the resin / adsorbent is sequentially contacted with at least one third mobile phase flow, and a desired new mass transfer equilibrium contact method is achieved with the discrete increment parameter conditions, so that at least one component is sequentially desorbed separately from the resin / adsorbent; A261: intermittently delivering a predetermined amount of at least one of the discharged and collected third mobile phase flows to the inlet of the integral unit (95) during a predetermined first time period; A262: During a predetermined second time period, after each delivery of the third mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit (95) so as to rapidly push the delivered third mobile phase through the resin / adsorbent installed in the integral unit (95), and at the same time, a vacuum environment is maintained on the other side of the integral unit (95) where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state; A263: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit (95); A264: The total time spent in steps A261-A263 is defined as the minimum time interval, also known as the third discrete mobile phase region; A265: repeating step A264 by increasing the discrete increments of the mobile phase parameter conditions until all the adjusted at least one third mobile phase flow is discretely carried out by the preset increments delivered in sequence, and the total cumulative minimum time interval is a plurality of third discrete mobile phase zones, which are named in sequence corresponding to the mobile phase parameter conditions delivered respectively, if the remaining components are still adsorbed by the resin / adsorbent, adding at least one fourth mobile phase flow so that the components can be eluted by a predetermined composition, the discrete increments of the mobile phase parameter conditions are adjusted to achieve the expected new mass transfer equilibrium contact method, so that the remaining components are sequentially desorbed from the resin / adsorbent separately, if the remaining components are not adsorbed by the resin / adsorbent, entering step A266; A266: intermittently delivering at least one predetermined amount of the first mobile phase flow discharged and collected in step A253 to the inlet of the integrated unit (95) within a predetermined first time period; A267: During a predetermined second time period, after each delivery of the first mobile phase, a pressurized inert gas is intermittently supplied to the top of the integral unit (95) so as to rapidly push the delivered first mobile phase through the resin / adsorbent installed in the integral unit (95), and at the same time, a vacuum environment is maintained on the other side of the integral unit (95) where the solid phase material is installed during the predetermined second time period to keep the resin / adsorbent material in a semi-dry state; A268: Collecting most of the processed mobile phase liquid material from the outlet at the bottom of the integral unit (95); A269: Define the total time spent in steps A266-A268 as the minimum time interval; A270: repeating step A269 until all at least one first mobile phase flow is delivered in sequence and the total cumulative minimum time interval is the last discrete mobile phase zone; A271: Finally, all defined regions are integrated in turn according to the mobile phase parameter conditions in the time domain, so that the characteristic separation curve of a specific separation system can be obtained by inputting the II mode; Wherein, the second mobile phase flow and the third mobile phase flow both include a liquid eluent of a predetermined composition.

9. A parameter differential separation process according to claim 8, characterized in that: The parameter differential moving bed is used to separate a component and at least one other component from a feed solution mixture containing one component and at least one other component dissolved in an eluent. It utilizes a new mass transfer equilibrium contact method, through a selected combination of mobile phase and solid phase resin / adsorbent, to obtain a characteristic elution curve between selected SI mode and II mode. The characteristic elution curve is used to establish a differential setting program. The specific steps are: adopt the general procedure of the new mass transfer equilibrium contact method, implement the differential setting program on the parameter differential moving bed through a single-stage recovery program, and then use the new mass transfer equilibrium contact method together with the mobile phase liquid flow transmission mechanism.

10. A parameter differential separation process according to claim 1, characterized in that: The upstream storage tank module (12) comprises an insulating jacket (11), a plurality of upper storage tanks (15) of different sizes and arranged inside the insulating jacket (11), and all the upper storage tanks (15) are arranged in an organized array in a selected pattern; the top surface of the upper storage tank (15) is provided with an inlet duct (16) penetrating the outer wall of the insulating jacket (11) and extending upward, and the bottom end of the inlet duct (16) is provided with a baffle a (1); the bottom surface of the upper storage tank (15) is provided with an outlet duct (17) penetrating the outer wall of the insulating jacket (11) and extending downward, and the top end of the outlet duct (17) is provided with a baffle b (2); The insulating jacket (11) comprises a manifold A (13) and a manifold B (14).

11. A parameter differential separation process according to claim 10, characterized in that: Each of the upper storage tanks (15) includes at least a portion of a feed solution, an eluent having a specific recovery mixture of specific composition, and an eluent; The plurality of upper storage tanks (15) include at least one feed tank and at least one eluent tank, wherein the feed tank includes a feed solution evenly distributed from the total feed solution throughput, and all feed tanks are integrated into a feed zone; the eluent tank includes an eluent and a modified eluent composition, and the eluent composition includes selected discrete increments of parameter conditions for respective eluent components; The modified eluent composition includes an eluent selected under discrete increasing parameter conditions, at least one different modified eluent is orderly arranged between the plurality of modified eluents, each eluent has a composition preset before the isopoint of the components, the modified eluent sequentially desorbs at least one of the first other components, and does not elute the adsorbed component and the remaining at least one other component, a plurality of recovery mixtures having specific compositions dissolved in the eluent discharged for recovery, and orderly contained in a plurality of upper storage tanks (15) as at least one first elution zone; At least one modified eluent is arranged in order with at least one incremental parameter condition, each eluent having a preset modified composition sequentially desorbs at least a portion of the component to a maximum desorbed portion, and does not elute at least one other component remaining adsorbed, a plurality of recovery mixtures having a specific composition of components dissolved in the eluent discharged for recovery, are sequentially contained in a plurality of upper storage tanks (15), as at least one component recovery zone and named as at least one product recovery zone; At least one modified eluent is sequentially arranged with at least one incremental parameter condition, each eluent having a preset isopoint composition at each time, higher than the isopoint of one component with the isopoint of all other components, and capable of desorbing at least one remaining another component, dissolving such sequentially a plurality of recovery mixtures having a specific composition of components in the eluent discharged for recovery, sequentially contained in a plurality of upper storage tanks (15), as at least a second elution zone and named a regeneration zone; and at least one eluent containing the eluent itself, for washing off the resin / adsorbent in contact with the feed liquid in the feed zone, sequentially contained in a plurality of upper storage tanks (15) and named as the wash zone; The adjusted mobile phase eluent having a discrete isopoint equilibrium differential state under parameter conditions is sequentially contacted with the resin / adsorbent installed in the integral unit (95), and the single adsorbed components having the corresponding discrete isopoint equilibrium differential state in contact with the surrounding are sequentially eluted, and the corresponding adjusted eluents in all integral units (95) are integrated; the adjusted eluent is mixed with the contacted particulate reverse phase resin / adsorbent, including a deionized pure water eluent, and the eluent is mixed with an organic solvent with a lower polarity to reduce the polarity of the adjusted eluent, and when the eluent is mixed with the organic solvent with a lower polarity, the volume percentage of the selected organic solvent is increased by 5% to 95% by volume for mixing; Alternatively: the eluent is adjusted to contact with the particulate normal phase resin / adsorbent, including a non-polar solvent eluent, and the eluent is mixed with a more polar organic solvent to increase the polarity of the adjusted eluent, thereby increasing the solubility of the adsorbed components to desorb and elute back into the surrounding adjusted mobile phase eluent.

12. A parameter differential separation process according to claim 11, characterized in that: The upstream rotary connection module comprises a circular multi-valve body I (19) driven by a driving member I, wherein the driving member I is a servo motor I (117) and a brake I (118); The circular multi-valve body I (19) comprises a horizontal circular plate a (102), a stretching rod a (119) fixedly connected to the inner wall of the horizontal circular plate a (102), a plurality of storage containers (21) arranged in a circular array on the top surface of the horizontal circular plate a (102), and a plurality of liquid outlet conduits (22) arranged in a circular array on the bottom surface of the horizontal circular plate a (102), the bottom end of the stretching rod a (119) is connected to the output end of the driving member I through a coupling, and a pressure-activated spring valve a (113) is arranged on the top outer wall of the liquid outlet conduit (22); The top surface of the storage container (21) is fixedly connected with an inlet end (101), and the number of the storage containers (21) and the outlet conduits (17) is the same and they are connected one-to-one through the conduits; The top surface of the horizontal circular plate a (102) is fixedly connected to an annular channel a (103) having a U-shaped cross section, and the storage container (21) is arranged inside the annular channel a (103); the top surface of the annular channel a (103) is fixedly connected to a connector a (104), the connector a (104) is connected to an outlet conduit (17), and the output end of the connector a (104) is connected to the top of the inlet end (101) through a liquid conduit D (105) after passing through the upper surface of the annular channel a (103), and the liquid conduit D (105) is arranged inside the annular channel a (103); A baffle h (106) is fixedly connected to the inner wall of the storage container (21) near the top; The inner circumferential wall of the annular channel a (103) is fixedly connected with an inner top railing a (108) and an inner bottom railing a (111) that match each other up and down, and the inner bottom railing a (111) is fixedly connected to the top surface of the horizontal circular plate a (102); the outer circumferential wall of the annular channel a (103) is fixedly connected with an outer top railing a (110) and an outer bottom railing a (112) that match each other up and down, and the outer bottom railing a (112) is fixedly connected to the top surface of the horizontal circular plate a (102); The top surface of the inner top rail a (108) is fixedly connected to the inner rim a (107), and the top surface of the outer top rail a (110) is fixedly connected to the outer rim a (109); the inner walls of the concentric cavities formed between the inner top rail a (108) and the inner bottom rail a (111) and between the outer top rail a (110) and the outer bottom rail a (112) are filled with a plurality of spheres a (123); the bottom of the outer top rail a (110) An upper semi-elliptical groove (120) is provided at the center of the surface, which matches with a lower semi-elliptical groove (121) provided at the center of the top surface of the outer bottom rail a (112). The upper semi-elliptical groove (120) and the lower semi-elliptical groove (121) are buckled to form a same concentric elliptical tunnel (122). The diameter of the ball a (123) is slightly larger than the vertical height of the concentric elliptical tunnel (122), thereby forming a gap a (124); The inner top railing a (108) and the outer top railing a (110) are provided with a semicircular groove a (125) and a semicircular groove c (127) at both sides of the bottom surface, the inner bottom railing a (111) and the outer bottom railing a (112) are provided with a semicircular groove b (126) and a semicircular groove d (128) at both sides of the top surface, and concentric circular tunnels a (129) and concentric circular tunnels b (130) are formed between the inner top railing a (108) and the inner bottom railing a (111) and between the outer top railing a (110) and the outer bottom railing a (112), and the inner walls of the concentric circular tunnels a (129) and the concentric circular tunnels b (130) are filled with ring-shaped sealing members (131) respectively; The bottom surface of the horizontal circular plate a (102) is fixedly connected with an annular fixed chamber a (115) having the same structure as the annular channel a (103), and the gap between the annular fixed chamber a (115) and the horizontal circular plate a (102) is infinitely small; The bottom inner wall of the annular fixed chamber a (115) is fixedly connected with funnels a (114) of the same number as the storage container (21) and corresponding in upper and lower positions; the bottom outer wall of the annular fixed chamber a (115) is fixedly connected with a joint b (116), the joint b (116) is connected to the outlet of the funnel a (114), the funnel a (114) is connected to the liquid outlet conduit (22), and a liquid conduit C (61) is provided between the joint b (116) and the storage container (28).

13. A parameter differential separation process according to claim 12, characterized in that: The separation module comprises a plurality of integral units (95) arranged inside the interlayer sleeve (36) and a plurality of single columns (23) arranged inside the integral units (95); The top surface of the integral unit (95) is provided with a reservoir (28), the top end of the reservoir (28) penetrates the top surface of the interlayer sleeve (36) and extends upward, the top end of the reservoir (28) is provided with a baffle c (3), the baffle c (3) comprises a circular rigid material (164) arranged on the inner wall of the circumference of the rigid sealing gasket (165), the top surface of the baffle c (3) is fixedly connected with a rigid steel wire (168), the outer wall of the rigid steel wire (168) is fixedly connected with a circular channel (167), the inner wall of the baffle c (3) is provided with a rigid center rod (166), the top end of the rigid center rod (166) is inserted into the interior of the circular channel (167); The inner wall of the storage container (28) is provided with a circular compartment (169), the circular compartment (169) comprising a circular opening a (171) and a circular opening b (172) opened on the outer wall thereof, and a side channel (170); A baffle d (4) is provided between the bottom end of the reservoir (28) and the top end of a nozzle (29) fixedly connected to the top inner wall of the integral unit (95), a baffle j (163) is fixedly connected to the bottom surface of the baffle d (4), and the liquid distributor is the nozzle (29); The outer wall of the storage container (28) between the baffle plate c (3) and the baffle plate d (4) is provided with a pipe three (9); The interlayer sleeve (36) is provided with two or more vertically mounted partitions inside, and the interlayer sleeve (36) includes a manifold C (26) and a manifold D (27); The bottom surface of the integral unit (95) is connected to a vacuum box (31), a side surface of the vacuum box (31) is provided with an air outlet pipe (48), and a side surface of the vacuum box (31) is provided with a manifold E (49); a liquid reservoir (33) is provided inside the vacuum box (31); The bottom surface of the integral unit (95) is provided with a funnel-shaped liquid collecting conduit (32), and the bottom inner wall of the liquid collecting conduit (32) is provided with a baffle e (65); A liquid conduit A (34) is provided at the bottom end of the liquid reservoir (33), a baffle f (5) is provided inside the liquid conduit A (34), a pipe five (10) is provided on the circumferential outer wall of the liquid conduit A (34) below the baffle f (5), and the pipe five (10) extends outward and penetrates a side surface of the interlayer sleeve (36); a pressure-activated check valve b (190) is provided on the circumferential outer wall of the liquid conduit A (34) near the top.

14. A parameter differential separation process according to claim 13, characterized in that: The top surface of the single column (23) is provided with an inlet end (24), the bottom surface of the single column (23) is provided with an outlet end, and a mesh filter (25) is provided inside the outlet end; the single column (23) retains a determined amount of resin / adsorbent solid material corresponding to the amount of resin / adsorbent installed as a mass transfer zone in the chromatogram; Alternatively, the single column (23) includes a plurality of stacking rings, the bottom end of the stacking ring is provided with a mesh filter (25) for preventing the granular resin / adsorbent material from being discharged, and an independent space is left between two adjacent stacking rings, and the top of the stacking ring is provided with an inlet end (24), the resin / adsorbent content in each stacking ring is different, and the resin / adsorbent filler in the stacking ring is a combination of anion exchanger, cation exchanger, reverse phase, normal phase, activated carbon and catalyst.

15. A parameter differential separation process according to claim 14, characterized in that: The downstream rotary connection module comprises a circular multi-valve body II (37) driven by a driving member II, wherein the driving member II comprises a servo motor II (148) and a brake II (149); The circular multi-valve body II (37) comprises a horizontal circular plate b (134), a stretching rod b (150) fixedly connected to the inner wall of the horizontal circular plate b (134), a plurality of transfer containers (38) arranged in a circular array on the top surface of the horizontal circular plate b (134), and a plurality of output conduits (39) arranged in a circular array on the bottom surface of the horizontal circular plate b (134) and equal in number to the transfer containers (38). The bottom end of the stretching rod b (150) is connected to the output end of the driving member II through a coupling; a pressure-activated spring valve b (133) is arranged on the top outer wall of the transfer container (38), and an opening end (132) is fixedly connected to the top surface of the transfer container (38); The top surface of the horizontal circular plate b (134) is fixedly connected to an annular channel b (135) having a U-shaped cross section, and the transfer container (38) is arranged inside the annular channel b (135); the top surface of the annular channel b (135) is fixedly connected to a joint c (136), the joint c (136) is connected to the liquid conduit A (34), and the output end of the joint c (136) is connected to the top of the opening end (132) through the liquid conduit E (137) after passing through the upper surface of the annular channel b (135); A baffle i (138) is fixedly connected to the inner wall of the transfer container (38) near the top; The bottom surface of the horizontal circular plate b (134) is fixedly connected with an annular fixed chamber b (146) having the same structure as the annular channel b (135), and the gap between the annular fixed chamber b (146) and the horizontal circular plate b (134) is infinitely small; The bottom inner wall of the annular fixed chamber b (146) is fixedly connected with the same number of funnels b (145) as the transfer container (38) and corresponding in upper and lower positions; the bottom outer wall of the annular fixed chamber b (146) is fixedly connected with a joint d (147), the joint d (147) is connected to the outlet of the funnel b (145), and the funnel b (145) is connected to the output conduit (39); The inner circumferential wall of the annular channel b (135) is fixedly connected with an inner top railing b (140) and an inner bottom railing b (143) that match each other up and down, and the inner bottom railing b (143) is fixedly connected to the top surface of the horizontal circular plate b (134); the outer circumferential wall of the annular channel b (135) is fixedly connected with an outer top railing b (142) and an outer bottom railing b (144) that match each other up and down, and the outer bottom railing b (144) is fixedly connected to the top surface of the horizontal circular plate b (134); The top surface of the inner top rail b (140) is fixedly connected to the inner rim b (139), and the top surface of the outer top rail b (142) is fixedly connected to the outer rim b (141); the inner walls of the concentric cavities respectively formed between the inner top rail b (140) and the inner bottom rail b (143) and between the outer top rail b (142) and the outer bottom rail b (144) are filled with a plurality of spheres b (154); the outer top rail b (14 2) is provided with an upper semi-arc groove (151) at the center of the bottom surface, which matches with a lower semi-arc groove (152) provided at the center of the top surface of the outer bottom rail b (144), and the upper semi-arc groove (151) and the lower semi-arc groove (152) are buckled to form a same concentric tunnel (153), and the diameter of the ball b (154) is slightly larger than the vertical height of the concentric tunnel (153), thereby forming a gap b (155); The inner top rail b (140) and the outer top rail b (142) are provided with a semicircular groove e (156) and a semicircular groove h (159) at both sides of the bottom surface, the inner bottom rail b (143) and the outer bottom rail b (144) are provided with a semicircular groove f (157) and a semicircular groove h (159) at both sides of the top surface, respectively, between the inner top rail b (140) and the inner bottom rail b (143) and between the outer top rail b (142) and the outer bottom rail b (144) are formed concentric circular tunnels c (160) and concentric circular tunnels d (161), respectively, and the inner walls of the concentric circular tunnels c (160) and the concentric circular tunnels d (161) are filled with O-type seals (162) respectively.

16. A parameter differential separation process according to claim 15, characterized in that: The downstream storage tank module (40) comprises a plurality of hollow sleeves (41) distributed in an array, and a lower storage tank (44) disposed inside the hollow sleeves (41), wherein the hollow sleeves (41) are arranged in an organized array in a selected pattern; The top surface of the lower storage tank (44) is provided with an infusion conduit (45) penetrating the outer wall of the hollow sleeve (41) and extending upward, and a baffle g (6) is provided at the top end of the infusion conduit (45); The top surface of the lower storage tank (44) is provided with a pipeline six (62); The bottom surface of the lower storage tank (44) is provided with a drainage pipe (46) penetrating the outer wall of the hollow sleeve (41) and extending downward, and the drainage pipe (46) is connected to the volumetric pump; A liquid level sensor (63) is disposed inside the lower storage tank (44), and a liquid infusion tube (64) is disposed on the top surface of the lower storage tank (44); The lower storage tank (44) includes a manifold F (42) and a manifold G (43).

17. A parameter differential separation process according to claim 16, characterized in that: The lower storage tank (44) comprises at least one product storage tank for storing a specific concentrated component product, at least one by-product storage tank for storing at least one other concentrated component by-product, and a plurality of recovered mixtures sequentially contained in the lower storage tank (44); During each duration of the time period, the discharged liquid is distributed to one of the corresponding upper tanks (15) arranged in the upstream tank module (12), which contains: ① a liquid having a specific composition of components dissolved in the discharge solution and the eluent, which liquid is the composition of the components contained in the discharged liquid for recovery; ② When delivered in sequence within a specific time period, liquids from all liquids including the feed solution and the recovered mixture of the discharged liquid and the eluent collected within the same time period, i.e., the specific composition of the components dissolved in the discharged solution and the eluent, are respectively distributed to a corresponding one of the upper storage tanks (15), all of which are the composition of the components contained in the discharged liquid, and are arranged in the corresponding areas including the feed area, the regeneration area and the washing area in a specified order; The lower storage tank (44) in the downstream storage tank module (40) contains a specific recovery mixture having a specific composition of components dissolved in the effluent solution and the eluent for recovery, at least one product storage tank for holding a specific concentrated component product and a by-product storage tank for holding at least one other concentrated component by-product.

18. A parameter differential separation process according to claim 17, characterized in that: The inert gas supply module supplies a wide range of pressurized inert gas by establishing a closed loop, providing a mobile phase liquid flow transmission mechanism, including combining an upstream storage tank module (12), an upstream rotary module, a separation module, a downstream rotary module and a downstream storage tank module (40) with liquid fluid transmission; the inert gas supply module includes a closed vacuum environment loop that is sequentially connected to form a closed loop and is arranged at the bottom of the integral unit (95), an upstream wide-area inert gas supply loop and a downstream wide-range inert gas supply loop that are arranged at the top of the integral unit (95); The closed vacuum environment loop comprises an aerosol separator (50), a liquid reservoir (33), a central vacuum pump (51), a water reservoir (52), a liquid guide tube (53) fixedly connected to the bottom surface of the water reservoir (52), an inert gas generator (54) and a steel tank container (55); the gas outlet of the aerosol separator (50) is connected to one end of the central vacuum pump (51) and the water reservoir (52) through a conveying conduit; the gas inlet and outlet ends of the inert gas generator (54) are respectively connected to the gas outlet end of the central vacuum pump (51) and the gas inlet end of the steel tank container (55); the gas inlet of the aerosol separator (50) is connected to a manifold P (84), and the output end of the manifold P (84) is connected to the input end of a plurality of gas outlet pipes (48); the vacuum degree of the closed vacuum environment loop is 15 to 27 in-Hg; The upstream wide-area inert gas supply loop comprises a first gas transmission pipeline (66) connected to the medium-pressure gas outlet of the steel tank container (55), a manifold H (67) connected to the input end of the pipeline second (8) and the output end of the first gas transmission pipeline (66), a second gas transmission pipeline (68) connected to the low-pressure gas outlet of the steel tank container (55), a manifold J (69) connected to the input end of the pipeline first (7) and the output end of the second gas transmission pipeline (68), a third gas transmission pipeline (70) connected to the high-pressure gas outlet of the steel tank container (55), and a third gas transmission pipeline (71) connected to the input end of the pipeline third (9) and the output end of the third gas transmission pipeline (72). a manifold K (71) connected to the output end of the pipeline (70), an online gas temperature regulator (56) having one end connected to the output end of the steel tank container (55), a four-way gas transmission pipeline (72) connected to the output end of the online gas temperature regulator (56), and a manifold L (57) connected to the input end of the pipeline four (30) and the output end of the four-way gas transmission pipeline (72), wherein the pipeline four (30) is arranged on the top surface of the integral unit (95), the pipeline two (8) is arranged on the circumferential outer wall of the outlet conduit (17), and the pipeline one (7) is arranged on the top outer wall of the upper storage tank (15); The downstream wide-range inert gas supply loop comprises a five-way gas pipeline (73) connected to the other medium-pressure gas outlet end of the steel tank container (55), a manifold M (74) connected to the input end of pipeline five (10) and the output end of the five-way gas pipeline (73), a six-way gas pipeline (75) connected to the other high-pressure gas outlet end of the steel tank container (55), and a manifold N (76) connected to the input end of pipeline six (62) and the output end of the six-way gas pipeline (75).

19. A parameter differential separation process according to claim 18, characterized in that: The inert gas is one of nitrogen, carbon dioxide, argon and air, or a mixture of gases; the pressure level of the medium-range pressurized inert gas in the upstream tank module (12) is 55-70psi; the pressure level of the low-range pressurized inert gas in the upstream tank module (12) is 40-55psi; the pressure level of the low-range pressurized inert gas in the separation module is 40-55psi; the pressure level of the medium-range pressurized inert gas in the separation module is 55-70psi; the pressure level of the high-range pressurized inert gas in the downstream tank module (40) is 70-90psi.

20. A parameter differential separation process according to claim 1, characterized in that: The differential setting procedure includes setting at least one region corresponding to at least one first mobile phase flow, setting at least one region corresponding to at least one second mobile phase flow, setting at least one region corresponding to at least one third mobile phase flow, and a predetermined plurality of alternative circulating mobile phase flows returning to the predetermined regions; The differential setting program includes a predetermined plurality of alternative recycled mobile phase flows for intermittent delivery to the parametric differential moving bed; wherein the mobile phase flow is a replacement for at least one first mobile phase flow stored in a corresponding upper storage tank (15) in the upstream storage tank module (12); Or: the mobile phase flow replaces at least one corresponding second mobile phase flow stored in a corresponding upper storage tank (15) in the upstream storage tank module (12); Alternatively, the mobile phase flow replaces at least one corresponding third mobile phase flow stored in a corresponding upper storage tank (15) in the upstream storage tank module (12).

21. A parameter differential separation process according to claim 20, characterized in that: The differential setting procedure applied to the parameter differential moving bed comprises the following steps: B1: Determine the optimal full-strength adsorption capacity of the resin / adsorbent at a predetermined feed throughput and divide the optimal full-strength adsorption capacity by a pre-selected number; The optimal full strength adsorption amount divides the resin / adsorbent into equal sub-amounts in at least one single column (23) disposed in a single integral unit (95); the preselected number of digits is equal to the number of single columns (23) disposed in a single integral unit (95) in each region; B2: In the general procedure of the new mass transfer equilibrium contact method, between the selected input modes SI mode and II mode, a characteristic elution curve represented in the time domain is generated according to a predetermined type of liquid distributor, by intermittently delivering a predetermined volume of a feed solution containing one component and at least one other component to the integral unit (95), and then by the general procedure of the new mass transfer equilibrium contact method, after the introduction of the feed solution, by intermittently delivering a plurality of circulating streams and eluents of predetermined volumes in a specific order, the adsorbed components are sequentially eluted to obtain at least one specific concentrated product component, to obtain another concentrated component of at least one by-product, and to obtain a plurality of recovered mixtures; B3: decomposing the elution curve in sub-time order in the total cumulative time domain, and then dividing each sub-time by the minimum time interval to obtain the range of the number of overall cells (95) set as the corresponding region; B4: Divide the total input volume of the mobile phase solution by the number of the whole units (95) to obtain the partial volume required for each minimum time interval in the corresponding area, and then divide the partial volume by a pre-selected number to further distinguish as multiple continuous liquid drop amounts; B5: assigning all integral cells (95) together with each liquid to the range of a specific liquid region; B6: Arrange all liquid zones in the same order in a parametric differential moving bed in an infinite cycle for various transported liquids; B7: Predetermined volumes of various specific recovery mixtures in step B2 are sequentially prepared into corresponding lower storage tanks (44) in the downstream storage tank module (40) to support liquid distribution through the closed loop of the upstream storage tank module (12), the upstream rotary module, the separation module, the downstream rotary module, and the downstream storage tank module (40), and then returned to the downstream storage tank module (40) by the driving force provided by the mobile phase liquid flow transmission mechanism; The preselected number is a finite integer ≥ 1, and when the integer = 1, B1 contains a predetermined amount of solid phase resin / adsorbent as a single integral unit (95) itself distributed in a single column (23).

22. A parameter differential separation process according to claim 21, characterized in that: B6, all regions arranged in the same order are integrated and combined, and the specific operation is: B61: providing at least one region between the selectively introduced at least one amount of the first mobile phase flow and the plurality of first discrete mobile phase flows, in contact with the installed resin / adsorbent packing in the time domain, to perform the intended mass transfer contact as the first mobile phase region; B62: providing at least one region between the selective introduction of at least one amount of the second mobile phase flow and the plurality of second discrete mobile phase flows, in contact with the installed resin / adsorbent packing in the time domain, to perform the intended mass transfer contact as the second mobile phase region; B63: providing at least one region between the selective introduction of at least one amount of the third mobile phase flow and the plurality of third discrete mobile phase flows, in contact with the disposed resin / adsorbent filler in the time domain, to perform the intended mass transfer contact as the third mobile phase region; B64: at least one region is provided between the selective introduction of at least one amount of a fourth and a fifth mobile phase flow and a plurality of fourth and a fifth discrete mobile phase flows, in contact with the disposed resin / adsorbent filler in the time domain for the intended mass transfer contact, as a corresponding fourth, fifth ... and so on, until all adsorbates in the mobile phase region are sequentially eluted; B65: setting at least one zone corresponding to the introduction of at least one last mobile phase flow in contact with the treated resin / adsorbent packing in the time domain to perform the expected mass transfer contact as the last mobile phase zone; B66: and predetermined multiple replacement circulating mobile phase flows return to the predetermined above-mentioned areas to replace the solutions set in the above-mentioned corresponding areas, so as to increase the concentration of the separated components and save the consumption of the corresponding solutions; B67: The entire area of ​​each region of the tissue is sequentially integrated to obtain a characteristic separation curve for eliminating chromatographic displacement zones and further arranging this difference scheme.

23. A parameter differential separation process according to claim 22, characterized in that: The single-stage recovery procedure simultaneously transfers all kinds of liquids on a parameter differential moving bed through the general procedure of a new mass transfer equilibrium contact method and a differential setting procedure between two phases for simultaneously recovering multiple streams and eluents.

24. A parameter differential separation process according to claim 23, characterized in that: The single-stage recovery procedure is adopted in a parametric differential moving bed to achieve the following separation process applicable to a single integral unit (95): Ⅰ: Maintaining all upper storage tanks (15) in the upstream storage tank module (12) within a selected temperature range, wherein: ① at least one upper storage tank (15) is arranged in the first mobile phase area, each upper storage tank (15) contains at least one predetermined selected first mobile phase flow and a plurality of first discrete mobile phase flows; ② at least one upper storage tank (15) is arranged in the second mobile phase area, each upper storage tank (15) contains at least one predetermined selected second mobile phase flow and a plurality of second discrete mobile phase flows; ③ installing at least one upper storage tank (15) in the third mobile phase zone, each upper storage tank (15) containing at least one predetermined selected third mobile phase flow and a plurality of third discrete mobile phase flows; ④ at least one upper storage tank (15) is arranged in the fourth, fifth, and so on mobile phase zones, each upper storage tank (15) containing at least one predetermined fourth or fifth mobile phase flow and a plurality of fourth or fifth discrete mobile phase flows; ⑤ at least one upper storage tank (15) arranged in the last mobile phase zone, each upper storage tank (15) containing at least one predetermined selected last discrete mobile phase flow; II: Maintaining all lower storage tanks (44) in the downstream storage tank module (40) within a selected temperature range, wherein: At least one lower storage tank (44) is allocated to receive liquid delivered from a specific upper storage tank (15), which is arranged in an upstream storage tank module (12) of a first mobile phase zone, and at least one predetermined first mobile phase flow and a plurality of first discrete mobile phase flows are contacted with a resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method; At least one lower storage tank (44) is designated to receive liquid delivered from a specific upper storage tank (15) disposed in an upstream storage tank module (12) of a second mobile phase zone, and at least one predetermined second mobile phase flow and a plurality of second discrete mobile phase flows are contacted with a resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method; At least one lower storage tank (44) is designated to receive liquid delivered from a specific upper storage tank (15) disposed in an upstream storage tank module (12) of a third mobile phase zone, and at least one predetermined selected third mobile phase flow and a plurality of third discrete mobile phase flows are contacted with a resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method; At least one lower storage tank (44) is designated to receive liquid delivered from a specific upper storage tank (15) of an upstream storage tank module (12) disposed in a fourth or fifth mobile phase zone, and at least one predetermined selected fourth or fifth mobile phase stream and a plurality of fourth or fifth discrete mobile phase streams are contacted with a resin / adsorbent solid phase filler to obtain a new mass transfer equilibrium contact method; At least one lower storage tank (44) is designated to receive liquid delivered from a specific upper storage tank (15) disposed in the last mobile phase zone of the upstream storage tank module (12), and at least one predetermined last mobile phase flow and last discrete mobile phase flow contact the resin / adsorbent solid phase filler to clean and wash away the residual resin / adsorbent solid filler; according to - The steps of allocating at least one product storage tank for holding a specific concentrated component product, at least one byproduct storage tank for holding at least one other concentrated component byproduct, and then preparing each circulating liquid stream based on the obtained elution profile, the composition of dissolved limiting solutes specifically modifying the characteristic parameters of the eluent solution mixture; III: The single integral unit (95) is further operated together with the mobile phase liquid flow transmission mechanism by the new mass transfer equilibrium contact method, wherein each mobile phase liquid stored in the corresponding area of ​​the corresponding upper storage tank (15) is sequentially dripped into the separation module in a predetermined volume format in the above order to produce the expected new mass transfer equilibrium contact method, and the liquid is continuously delivered according to the repeated procedure after each dripping, and once the predetermined amount of liquid solution is completed, it is distributed and delivered to the reservoir (28) at the top of the single integral unit (95), wherein: a) during a first time period, intermittently delivering a forced discharge dose of liquid dripping from the top of a single integral unit (95) through an alternating supply mode between two separate wide range pressurized inert gas routes to rapidly pass through the resin / adsorbent to complete a new mass transfer equilibrium contact method between the two phases to promote adsorption of components onto the resin / adsorbent or to elute adsorbed components from the resin / adsorbent; 2) while maintaining the vacuum environment at the bottom of the integral unit (95), draining the treated liquid solution into the liquid reservoir (33) below, and keeping the resin / adsorbent in a semi-dry state; iii) during a second time period, intermittently collecting the discharged liquid in the liquid reservoir (33), and conveying the collected liquid to each designated lower storage tank (44) in the downstream storage tank module (40); iv) repeating steps 1) to 3) to complete all liquids set in at least one upper storage tank (15) set in the first mobile phase zone, and the liquid collected from the bottom of the integral unit (95) is transferred therethrough as a circulating flow to the designated lower storage tank (44) of the last mobile phase zone; v) repeating steps 1) to 3) to complete all liquids disposed in at least one upper storage tank (15) disposed in the second mobile phase zone, and transferring the liquid collected from the bottom of the integral unit (95) back to the designated lower storage tank (44) of the second mobile phase zone as a circulating flow; vi) repeating steps 1) to 3) to complete all liquids disposed in at least one upper storage tank (15) disposed in the third mobile phase zone, and transferring the liquid collected from the bottom of the integral unit (95) back to the designated lower storage tank (44) of the third mobile phase zone as a circulating flow; VII) repeating steps 1) to 3) to complete the arrangement of all liquids in at least one upper storage tank (15), the upper storage tank (15) being arranged in the fourth and fifth mobile phase zones, through which the liquid collected from the bottom of the integral unit (95) is transferred as a circulating flow back to the corresponding lower storage tank (44) designated in the fourth, fifth, etc. mobile phase zones; VIII) repeating steps 1) to 3) to complete the setting of all liquids, at least one upper storage tank (15) being set in the last mobile phase zone, through which the liquid collected from the bottom of the integral unit (95) is transferred back to the designated lower storage tank (44) of the first mobile phase zone as a circulating flow; The mobile phase comprises a feed liquid mobile phase of at least one desired component and a solute mixture separated from at least one other component as a uniform liquid solution mixture of finite components; the solute composition is dissolved in the solution in discrete increments of parameters with increasing discrete parameters so as to achieve a desired new mass transfer equilibrium contact method so that at least one of the components can be sequentially desorbed from the resin / adsorbent.

25. A parameter differential separation process according to claim 1, characterized in that: The operation contents of the single-stage recovery procedure include the following supplements: C1: The liquid is transported in a closed loop, starting from the downstream tank module (40), through the upstream tank module (12) attached to the pressurized inert gas supply module, as well as the rotating and positioning device and the sealing mechanism in the upstream rotary module, completing the new mass transfer equilibrium contact method in the separation module, and then returning to the downstream tank module (40) through the rotating and positioning device and the sealing mechanism in the downstream rotary module; C2: Steady-state operating procedures during each time interval spent; C3: Restoring to a fresh semi-dry state in a parameter differential moving bed for termination operation; The C1 step also includes the following: C11: the integral unit (95) located at the first position in the separation module receives a predetermined volume of liquid delivery, while the remaining integral units (95) do not receive liquid; C12: After each simultaneous delivery of various liquids in a predetermined volume sequence, the liquids are delivered intermittently by alternating the supply between two separate wide-range pressurized inert gas paths to force the dripping dosed liquid to be discharged quickly after passing through the resin to complete the expected new mass transfer equilibrium contact method between the solid phase and the liquid phase; C13: while maintaining a closed vacuum environment, each treated liquid solution is discharged into a corresponding transfer container (38), so that the resin / adsorbent in the integral unit (95) is in a semi-dry state; C14: intermittently collect the discharged liquid in each transfer container (38), and transmit each collected liquid to the lower storage tank (44) through the downstream rotary module through an extensive pressurized inert gas supply route; C15: Repeat steps C11-C14, and simultaneously cover the first integral unit (95) and the second integral unit (95) receiving liquid in the separation module, until the first receiving liquid arranged in the upstream rotary module and the first receiving liquid arranged in the transfer container (38) of the downstream rotary module return to their initial positions, completing one rotation cycle, and thus completing the startup operation; the various liquids recovered in said startup operation as one specific concentrated component of at least one product in the product storage tank, and another concentrated component of at least one byproduct in each byproduct storage tank, a plurality of recovered mixtures, wherein one specific recovered mixture has a specific composition of components dissolved in the drain solution, and the eluents held in each storage tank in a specific order; The content of the steady-state operation procedure in C2 includes the following steps: C21: Liquid delivery by means of a wide range of pressurized inert gas, delivering predetermined volumes of various liquids in various circulating flows, while simultaneously delivering all available liquids from the upper storage tank (15), forcing it into the storage container (21) through various pressurized inert gas supply routes; C22: After delivering various liquids, intermittent delivery is performed by alternating supply between two separate wide range pressurized inert gas paths to force the dripping dosed liquid to be discharged quickly after passing through the resin / adsorbent to complete the expected new mass transfer contact equilibrium method between the solid phase and the liquid phase; C23: while maintaining a closed vacuum environment, discharging each treated liquid solution into a corresponding transfer container (38), so that the resin / adsorbent disposed in each integral unit (95) is in a semi-dry state; C24: intermittently collect various discharged liquids in each transfer container (38), and transmit the collected liquids to the lower storage tank (44) through the downstream rotary module via a wide range of pressurized inert gas supply routes; the various liquids recovered in said steady state operating procedures as a specific concentrated component of at least one product in each product storage tank, and another concentrated component of at least one by-product in each by-product storage tank, various recovered mixtures [a specific recovered mixture in the mixtures having a specific composition of said components dissolved in the discharged solution], and the eluent held in each storage tank in a specific order; The termination operation in C3 is used to generate the reverse operation procedure of the startup operation of the resin / adsorbent installed in the separation module. The specific content of the termination operation includes the following supplements: C31: the integrated unit (95) located at the first position in the separation module stops receiving the predetermined volume of liquid delivery, while the remaining integrated units (95) continue to receive the liquid at the same time; C32: After each simultaneous delivery of various liquids in a predetermined volume sequence, the liquids are delivered intermittently by alternating the supply between two separate wide-range pressurized inert gas paths to force the dripping dosed liquid to be discharged quickly after passing through the resin to complete the expected new mass transfer equilibrium contact method between the solid phase and the liquid phase; C33: while maintaining a closed vacuum environment, the treated liquid solution is discharged into a corresponding transfer container (38), so that the resin / adsorbent in the integral unit (95) is in a semi-dry state; C34: intermittently collect the discharged liquid in each transfer container (38), and transmit each collected liquid to the lower storage tank (44) through the downstream rotary module through an extensive pressurized inert gas supply route; C35: repeating steps C31-C34, while covering the first integral unit (95) and the second integral unit (95) for receiving liquid in the separation module to stop receiving liquid, until the first receiving liquid arranged in the upstream rotary module and the first receiving liquid arranged in the transfer container (38) of the downstream rotary module return to their initial positions, completing one rotation cycle, and thus completing the termination operation; In the single-stage recovery procedure, the wide range of pressure levels of the pressurized inert gas is 40-90 psi, wherein the low range of the pressurized inert gas pressure level is 40-55 psi, the medium range of the pressurized inert gas pressure level is 55-70 psi, and the high range of the pressurized inert gas pressure level is 75-90 psi.

26. A parameter differential separation process according to claim 19, characterized in that: The heat medium in the insulating jacket (11), the interlayer jacket (36) and the hollow jacket (41) is water at a temperature of 0-100°C, wherein salt water or a mixture of water and antifreeze is used for lower temperatures below 0°C; mineral oil is used for temperatures above 100°C.

27. A parameter differential separation process according to claim 1, characterized in that: The general procedure of the new mass transfer equilibrium contact method is: the mobile phase liquid material is sequentially delivered through a predetermined type of liquid distributor, and a predetermined volume of the delivered fluid is conducted in a short time to be sprinkled into the wetted area of ​​the resin / adsorbent, thereby achieving the expected new mass transfer equilibrium contact method between the two phases.

28. A parameter differential separation process according to claim 23, characterized in that: The single-stage recovery procedure is adopted in a parametric differential moving bed to achieve the following separation process applicable to a single integral unit (95): I: Maintaining all lower storage tanks (44) in the downstream storage tank module (40) within a selected temperature range, wherein: At least one lower storage tank (44) is allocated to receive the liquid collected and discharged from the matching specific multiple integral units (95), and the lower storage tank (44) is arranged in the downstream storage tank module (40) of the first mobile phase zone, and at least one predetermined first mobile phase flow and a plurality of first discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method; At least one lower storage tank (44) is allocated to receive the liquid collected and discharged from the matching specific multiple integral units (95), and the lower storage tank (44) is arranged in the downstream storage tank module (40) of the second mobile phase zone, and at least one predetermined second mobile phase flow and a plurality of second discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method; At least one lower storage tank (44) is allocated to receive the liquid collected and discharged from the matching specific multiple integral units (95), and the lower storage tank (44) is arranged in the downstream storage tank module (40) of the third mobile phase zone, and at least one predetermined third mobile phase flow and a plurality of third discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method; At least one lower storage tank (44) is allocated to receive the liquid collected and discharged from the matching specific multiple integral units (95), and the lower storage tank (44) is arranged in the downstream storage tank module (40) of the fourth and fifth mobile phase zones, and at least one predetermined fourth and fifth mobile phase flow and a plurality of fourth and fifth discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to achieve a new mass transfer equilibrium contact method; At least one lower storage tank (44) is allocated to receive the liquid collected and discharged from the matching specific multiple integral units (95), and the lower storage tank (44) is arranged in the downstream storage tank module (40) of the last mobile phase zone, and at least one predetermined last mobile phase flow and a plurality of last discrete mobile phase flows are in contact with the resin / adsorbent solid phase filler to clean and wash away the residual resin / adsorbent solid filler; exist After the last lower storage tank (44) of the last mobile phase zone in the middle, a lower storage tank (44) is provided to receive the corresponding pressurized inert gas from its source into the designated integral unit (95) top reservoir (28) to flush the remaining liquid in the resin / adsorbent solid phase packing to maintain a semi-dry state of the new mass transfer equilibrium contact method; according to - The steps of allocating at least one product storage tank for holding a specific concentrated component product, at least one byproduct storage tank for holding at least one other concentrated component byproduct, and then preparing each circulating liquid stream based on the obtained elution profile, the composition of dissolved limiting solutes specifically modifying the characteristic parameters of the eluent solution mixture; II: The plurality of integral units (95) are further operated together with the mobile phase liquid flow transmission mechanism through the new mass transfer equilibrium contact method, and the mobile phase liquids stored in the corresponding areas of the corresponding lower storage tanks (44) are simultaneously and sequentially dripped into the separation module in a predetermined volume format in the above order to produce the expected new mass transfer equilibrium contact method, and the liquid is continuously delivered according to the repeated procedure after each dripping, and once the predetermined amount of liquid solution is completed, it is distributed and delivered to the reservoirs (28) at the top of each integral unit (95), wherein: a) during a first time period, intermittently delivering a forced discharge dose of liquid dripping from the top of a single integral unit (95) through an alternating supply mode between two separate wide range pressurized inert gas routes to rapidly pass through the resin / adsorbent to complete a new mass transfer equilibrium contact method between the two phases to promote adsorption of components onto the resin / adsorbent or to elute adsorbed components from the resin / adsorbent; 2) while maintaining the vacuum environment at the bottom of the integral unit (95), draining the treated liquid solution into the liquid reservoir (33) below, and keeping the resin / adsorbent in a semi-dry state; iii) during a second time period, intermittently collecting the discharged liquid in the liquid reservoir (33), and conveying the collected liquid to each designated lower storage tank (44) in the downstream storage tank module (40); iv) repeating steps 1) to 3) to complete all liquids set in at least one lower storage tank (44) set in the first mobile phase zone, and the liquid collected from the bottom of the integral unit (95) is transferred therethrough as a circulating flow to the designated lower storage tank (44) of the last mobile phase zone; v) repeating steps 1) to 3) to complete all liquids set in at least one lower storage tank (44) set in the second mobile phase zone, and transferring the liquid collected from the bottom of the integral unit (95) back to the designated lower storage tank (44) of the second mobile phase zone as a circulating flow; vi) repeating steps 1) to 3) to complete all liquids disposed in at least one lower storage tank (44) disposed in the third mobile phase zone, and transferring the liquid collected from the bottom of the integral unit (95) back to the designated lower storage tank (44) of the third mobile phase zone as a circulating flow; VII) repeating steps 1) to 3) to complete the placement of all liquids in at least one lower storage tank (44), the lower storage tank (44) being placed in the fourth and fifth mobile phase zones, and the liquid collected from the bottom of the integral unit (95) being transferred back to the corresponding lower storage tank (44) designated in the fourth, fifth, etc. mobile phase zones as a circulating flow; VIII) repeating steps 1) to 3) to complete the setting of all liquids, at least one lower storage tank (44) being set in the last mobile phase zone, through which the liquid collected from the bottom of the integral unit (95) is transferred back to the designated lower storage tank (44) of the first mobile phase zone as a circulating flow; The mobile phase simultaneously introduces a feed liquid mobile phase containing at least one desired component and at least one other component to separate a solute mixture as a uniform liquid solution mixture of limited components; the solute composition is dissolved in the solution in discrete increments of parameters with increasing discrete parameters so as to achieve a desired new mass transfer equilibrium contact method so that at least one of the components can be sequentially desorbed from the resin / adsorbent.

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