An apparatus for the separation and purification of carrier-free lutetium-177

Abstract

The present invention belongs to the technical field of separation and purification of radioactive isotopes, and specifically relates to a device for separating and purifying carrier-free lutetium-177, which includes a mounting frame, a salt-transferring component arranged in the middle of the front side of the mounting frame, a valve component arranged in the middle of the rear side of the mounting frame, a separation and purification column arranged on one side of the salt-transferring component, a sample injection system arranged on one side of the valve component, a fraction component arranged above the mounting frame, and a waste liquid component arranged on one side of the mounting frame. By controlling the opening and closing of the valves in the sample injection system and the valve component through a control terminal, the flow of liquid in the separation and purification device is controlled, thereby realizing the functions of ytterbium-lutetium separation, lutetium salt-transferring concentration, and ytterbium salt-transferring recovery in the separation and purification device. The present invention solves the problems of the large overall volume and large floor area of the existing separation and purification device for carrier-free lutetium-177, the high requirement for the degree of automatic control, and the short service life of components.

Description

Technical Field

[0001] The invention belongs to the technical field of separation and purification of radioactive isotopes, in particular to a device for separation and purification of carrier-free lutetium-177. Background Art

[0002] Radioactive therapeutic drugs are medical drugs containing radioactive isotopes. In recent years, with the continuous progress of nuclear medicine research, the development of new radionuclides and radioactive drugs has greater targeting, increasing the possibility of preparing according to user requirements and combining radioactive drug diagnosis and treatment programs, which has greatly promoted the market expansion of radioactive therapeutic drugs.

[0003] Lutetium-177 is a therapeutic radionuclide that has attracted much attention in recent years. The maximum energy of the beta particles it emits is 0.42 MeV, and the average range in the tissue is 0.67 mm, which is very suitable for treating small or diffuse tumors, as well as tumors that are not suitable for surgical resection. In addition, Lutetium-177 also emits gamma rays (208 keV) and can be used for single-photon emission computed tomography (SPECT) to monitor and guide the treatment process. The half-life of Lutetium-177 is 6.7 days, making it very suitable for radiotherapy. The relatively short half-life minimizes damage to healthy human cells during the entire treatment; its relatively long half-life allows it to be labeled with biological molecules and delivered to hospitals after production.

[0004] In the prior art, there is a method of preparing lutetium-177 by separation and purification from a mixture of ytterbium and lutetium, wherein the steps of separation and purification mainly include ytterbium and lutetium separation, lutetium transsalt concentration and ytterbium transsalt recovery. In the prior art, these three process steps are usually carried out in different working equipment or devices, and then each product is transported between different devices through a transport structure or device, which makes the overall device for separation and purification of lutetium bulky. And due to the radioactivity of lutetium-177 itself, most of the overall devices for separation and purification need to be isolated with isolation equipment; and the overall device for separation and purification has a large volume and floor space, which also requires larger isolation equipment, which increases the preparation cost of lutetium-177 in disguise. In addition, due to the radiation properties of the processed samples, the degree of automation control of the entire process step is very high to avoid the impact of radiation on the operator. Radiation can also damage materials, cause functional failures, and affect the service life of parts. Summary of the invention

[0005] In view of the problems in the prior art that the overall device for separation and purification of carrier-free lutetium-177 is large in size and occupies a large area, requires a high degree of automation control and has a short service life of components, the object of the present invention is to provide a device for separation and purification of carrier-free lutetium-177.

[0006] The object of the present invention is achieved by the following technical solutions:

[0007] The present invention includes a mounting rack, a salt conversion assembly, a valve assembly, a separation and purification column, a sample injection system, a fraction assembly, a waste liquid assembly, a sample tank and a finished product tank. The salt conversion assembly includes a ytterbium salt conversion column and a lutetium salt conversion column. The ytterbium salt conversion column, the lutetium salt conversion column and the separation and purification column are respectively installed on the front side of the mounting rack, and the separation and purification column is located on one side of the salt conversion assembly. Quick connectors are provided at the inlet and outlet ends of the ytterbium salt conversion column and the lutetium salt conversion column. Cylinders equal in number to and corresponding one by one to the quick connectors at each inlet end are fixed on the mounting rack above the ytterbium salt conversion column and the lutetium salt conversion column, and cylinders equal in number to and corresponding one by one to the quick connectors at each outlet end are fixed on the mounting rack below the ytterbium salt conversion column and the lutetium salt conversion column. The cylinders control the opening and closing of the corresponding quick connectors, thereby realizing the connection or disconnection between the ytterbium salt conversion column, the lutetium salt conversion column and the pipeline. The valve assembly and the sample injection system are respectively installed on the rear side of the mounting rack. The fraction assembly includes a lutetium fraction tank and a ytterbium fraction tank. The lutetium fraction tank is installed on the mounting rack or arranged on one side of the mounting rack, and the ytterbium fraction tank is arranged on one side of the mounting rack or installed on the mounting rack. The waste liquid assembly includes at least one waste liquid tank, and the waste liquid tank is installed on the mounting rack or arranged on one side of the mounting rack. An energy spectrum detection probe is provided on the front side of the mounting rack, and an ultraviolet detector is provided on the mounting rack below the valve assembly. Ultraviolet detectors and reaction tubes are respectively provided on the pipeline between the separation and purification column and the waste liquid tank. The sample tank contains the target material solution to be separated. The control terminal controls the opening and closing of the valves in the sample injection system and the valve assembly, controls the target material solution to be separated to flow to the separation and purification column for separating ytterbium ions and lutetium ions. After separation, the lutetium fraction containing lutetium ions is collected in the lutetium fraction tank, and the ytterbium fraction containing ytterbium ions is collected in the ytterbium fraction tank. The lutetium fraction in the lutetium fraction tank is introduced into the lutetium salt conversion column for lutetium salt conversion and concentration, and the ytterbium fraction in the ytterbium fraction tank is introduced into the ytterbium salt conversion column for ytterbium salt recovery.

[0008] Wherein: The mounting rack includes a frame, a mounting plate A and a mounting plate B. The frame is the main body of the mounting rack. The separation and purification column is installed on one side inside the frame. The mounting plate A and the mounting plate B arranged front and back are installed on the other side inside the frame. The salt conversion assembly is installed on the outer side of the mounting plate A. The valve assembly and the sample injection system are installed on the outer side of the mounting plate B. The sample tank and the finished product tank are respectively arranged between the mounting plate A and the mounting plate B.

[0009] A material replacement tray for holding components is provided at the bottom of the mounting rack.

[0010] The lutetium fraction tank is one or more and is installed on the top of the mounting rack, and the ytterbium fraction tank is arranged on one side of the mounting rack.

[0011] The waste liquid assembly includes a first waste liquid tank, a second waste liquid tank and a third waste liquid tank. The first waste liquid tank is installed at the top of the mounting frame. The second waste liquid tank and the third waste liquid tank are respectively arranged on one side of the mounting frame. The ytterbium fraction tank is arranged on the top of the second waste liquid tank.

[0012] The ytterbium salt conversion column is one or a plurality of arranged side by side, and the lutetium salt conversion column is one or a plurality of arranged side by side.

[0013] The sampling system includes a sampling injection pump and a six-port sampling valve with a quantitative loop. The six-port sampling valve is respectively connected to a sample tank, a separation and purification column, a waste liquid tank and a mobile phase through pipelines. The sampling injection pump is arranged on the pipeline.

[0014] The finished product tank includes an ytterbium finished product tank and a lutetium finished product tank. Carrier-free lutetium-177 obtained by lutetium salt conversion and concentration is discharged into the lutetium finished product tank, and the solution recovered by ytterbium salt conversion is discharged into the ytterbium finished product tank.

[0015] Before separation and purification, the device is cleaned. The mobile phase transported by the feeding device enters the device after being heated by a heat exchanger. The heat exchanger includes a housing, a heating rod, a temperature sensor A, a coil rack and a heat exchange coil. The housing is filled with a heat-conducting medium. An inlet A and an outlet are respectively opened at the top of the housing. A coil rack is installed inside the housing. The heat exchange coil is wound on the coil rack. The two ends of the heat exchange coil are respectively communicated with the inlet A and the outlet. A heating rod and a temperature sensor A are respectively arranged inside the coil rack. The heating rod, the temperature sensor A, the coil rack and the heat exchange coil are all immersed in the heat-conducting medium. The upper ends of the heating rod and the temperature sensor A are fixed on the housing. The heating rod is energized to heat the heat-conducting medium. The mobile phase flows into the heat exchange coil from the inlet A and exchanges heat with the heated heat-conducting medium during the process of flowing through the heat exchange coil. The mobile phase after heat exchange flows out from the outlet.

[0016] The quick-connect fitting includes a top base, a top flow-through plate, an upper spring, a male fitting sleeve, an upper fitting inner core, a nut cover, a female fitting sleeve, a lower fitting inner core, and a bottom flow-through plate. The upper end of the top base is connected to the output end of the cylinder, and the lower end of the top base is hermetically connected to the upper end of the male fitting sleeve. The male fitting sleeve has a hollow internal structure, and the inner wall of the lower end of the hollow interior is inclined. A top flow-through plate is provided inside the male fitting sleeve. The upper fitting inner core is floatingly accommodated inside the male fitting sleeve. An upper spring is sleeved on the upper fitting inner core. The upper end of the upper fitting inner core is inserted into the central hole A of the top flow-through plate, and the lower end abuts against the inclined surface at the lower end of the hollow interior of the male fitting sleeve under the action of the upper spring. A liquid passage hole is formed in the top flow-through plate, and a liquid inlet B communicating with the liquid passage hole is formed in the top base. The female fitting sleeve is connected to the liquid inlet and outlet ends of the ytterbium transfer salt column or the lutetium transfer salt column. The nut cover is hermetically connected to the upper end of the female fitting sleeve. The lower end of the female fitting sleeve is threadedly connected to the bottom flow-through plate located inside the liquid inlet and outlet ends of the ytterbium transfer salt column or the lutetium transfer salt column. The bottom flow-through plate has a hollow internal structure, and the inner wall of the upper end of the hollow interior is inclined. The lower fitting inner core is floatingly accommodated inside the female fitting sleeve. A lower spring is sleeved on the lower fitting inner core. The lower end of the lower fitting inner core is inserted into the central hole B of the bottom flow-through plate, and the upper end abuts against the inclined surface at the upper end of the hollow interior of the female fitting sleeve under the action of the lower spring. The cylinder drives the top base and the male fitting sleeve to move towards the female fitting sleeve until the male fitting sleeve is hermetically abutted against the female fitting sleeve, thereby realizing the connection of the quick-connect fitting at the liquid inlet and outlet ends. The lower end of the upper fitting inner core abuts against the upper end of the lower fitting inner core. The liquid sequentially flows through the liquid inlet B, the liquid passage hole, the interior of the male fitting sleeve, the interior of the nut cover, the interior of the female fitting sleeve, and into the interior of the bottom flow-through plate at the liquid inlet end of the quick-connect fitting, and finally flows into the ytterbium transfer salt column or the lutetium transfer salt column through the gap between the lower end of the lower fitting inner core and the central hole B. After the salt transfer, it flows out through the interior of the bottom flow-through plate, the interior of the female fitting sleeve, the interior of the nut cover, the interior of the male fitting sleeve, the liquid passage hole, and the liquid inlet B at the liquid outlet end of the quick-connect fitting.

[0017] The advantages and positive effects of the present invention are as follows:

[0018] 1. The present invention controls the sample injection system, valve assembly, etc. through a control terminal, thereby controlling the flow of liquid in the separation and purification device, enabling the separation purification column in the device to separate the ytterbium-lutetium mixture, obtaining fractions containing ytterbium ions and lutetium ions, and flowing into the corresponding fraction tanks in the fraction assembly respectively. Then, the corresponding ytterbium salt and lutetium salt are obtained through post-treatment of the ytterbium ions and lutetium ions by the corresponding salt conversion assembly, fulfilling the separation and purification requirements of lutetium in the ytterbium-lutetium mixture. Among them, by reasonably arranging the salt conversion assembly, valve assembly, separation purification column, sample injection system, fraction assembly, and waste liquid assembly on and near the mounting rack, the various devices for separating and purifying the ytterbium-lutetium mixture are concentrated and reasonably distributed. This not only enables the device to achieve the function of separating and purifying lutetium in the ytterbium-lutetium mixture but also makes the overall device volume small enough through reasonable and compact space setting and distribution.

[0019] 2. All valve assemblies of the present invention are pneumatic valves, and the flow of each liquid in the device is achieved through pneumatic means. Moreover, the electronic components of each component are arranged outside the box body, thereby enabling the components inside the box body to avoid the influence of radioactive decay on the component life, ensuring the stability and reliability of the overall device. Additionally, the radiation resistance performance of the components is improved by adjusting the component materials to ensure the service life of the components. Therefore, through pneumatic full-automatic control, the entire process step does not require operator control, avoiding the influence of radiation on the operator. And through adjusting materials, adopting a pneumatic control structure, and anti-radiation adjustment of arranging the electronic components of each component outside the box body, the anti-radiation ability and service life of each component in the separation and purification device are greatly improved. Also, through the reasonable distribution and connection of each component, the volume of the separation and purification device is reduced.

[0020] 3. Quick connectors are provided at the inlet and outlet ends of the ytterbium salt conversion column and lutetium salt conversion column of the present invention, which can be connected or disconnected by the drive of a cylinder, facilitating the replacement of the ytterbium salt conversion column and lutetium salt conversion column by a manipulator. Brief Description of the Drawings

[0021] Figure 1 is a three-dimensional structure schematic diagram of the present invention;

[0022] Figure 2 is a front view of the structure of the present invention;

[0023] Figure 3 is a rear view of the structure of the present invention;

[0024] Figure 4 is a left view of the structure of the present invention;

[0025] Figure 5 is Figure 4 the top view of;

[0026] Figure 6It is the structural schematic diagram of the present invention;

[0027] Figure 7 It is Figure 1 the external structural schematic diagram of the quick-connect joint in the disconnected state;

[0028] Figure 8 It is Figure 7 the internal structural sectional view of

[0029] Figure 9 It is Figure 1 the external structural schematic diagram of the quick-connect joint in the connected state;

[0030] Figure 10 It is Figure 9 the internal structural sectional view of

[0031] Figure 11 It is Figure 6 the three-dimensional structural schematic diagram of the heat exchanger in

[0032] Figure 12 It is Figure 11 the main structural view of

[0033] Figure 13 It is Figure 12 the left view with the outer shell removed;

[0034] Figure 14 It is Figure 12 the A - A sectional view of

[0035] Figure 15 It is Figure 12 the top view of

[0036] Wherein: 1 is reagent tank A, 2 is reagent tank B, 3 is reagent tank C, 4 is reagent tank D, 5 is pump A, 6 is pump B, 7 is pump C, 8 is pump D, 9 is a heat exchanger, 901 is the housing, 902 is the liquid inlet A, 903 is the liquid outlet, 904 is the heating rod, 905 is temperature sensor A, 906 is the coil rack, 907 is the heat exchange coil, 10 is the mounting rack, 11 is the frame, 12 is mounting plate A, 13 is mounting plate B, 14 is the material replacement tray, 15 is the cylinder, 16 is the quick connector, 1601 is the top base, 1602 is the liquid inlet, 1603 is the top flow-through plate, 1604 is central hole A, 1605 is the liquid passage hole, 1606 is the upper spring, 1607 is the sealing ring, 1608 is the male connector sleeve, 1609 is the upper connector inner core, 1610 is the nut cover, 1611 is the female connector sleeve, 1612 is the lower connector inner core, 1613 is the bottom flow-through plate, 1614 is central hole B, 1615 is the lower spring, 20 is the salt conversion assembly, 21 is the ytterbium salt conversion column, 22 is the lutetium salt conversion column, 30 is the valve assembly, 31 is a one-position multi-way valve, 311 is a one-position four-way valve, 312 is a one-position six-way valve A, 313 is a one-position six-way valve B, 32 is a three-way valve, 320 is three-way valve A, 321 is three-way valve B, 322 is three-way valve C, 323 is three-way valve D, 324 is three-way valve E, 325 is three-way valve F, 326 is three-way valve G, 327 is three-way valve H, 328 is three-way valve I, 329 is three-way valve J, 40 is the separation and purification column, 50 is the injection system, 51 is the injection pump, 52 is the six-way injection valve, 53 is the quantitative loop, 54 is the sample tank, 60 is the fraction assembly, 61 is the lutetium fraction tank, 62 is the ytterbium fraction tank, 63 is the ytterbium finished product tank, 64 is the lutetium finished product tank, 70 is the waste liquid assembly, 71 is the first waste liquid tank, 72 is the second waste liquid tank, 73 is the third waste liquid tank, 80 is the energy spectrum detection probe, 801 is energy spectrum detection probe A, 802 is energy spectrum detection probe B, 90 is the ultraviolet detector, 100 is the reaction tube. Detailed implementation manners

[0037] For ease of understanding of the present invention, the present invention will be described more comprehensively below with reference to the relevant drawings. Several embodiments of the present invention are given in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0038] It should be noted that when an element is referred to as being "fixedly provided on" another element, it can be directly on the other element or there may also be an intermediate element. When an element is considered to be "connected" to another element, it can be directly connected to the other element or there may be an intermediate element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are only for the purpose of illustration.

[0039] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field to which this invention belongs. The terms used in the description of the present invention herein are for the purpose of describing specific embodiments only and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0040] As Figures 1 - 6 shown, the present invention includes a mounting frame 10, a salt conversion assembly 20, a valve assembly 30, a separation and purification column 40, a sample injection system 50, a fraction assembly 60, a waste liquid assembly 70, a sample tank 54, and a finished product tank. The salt conversion assembly 20 includes a ytterbium salt conversion column 21 and a lutetium salt conversion column 22. The ytterbium salt conversion column 21, the lutetium salt conversion column 22, and the separation and purification column 40 are respectively installed on the front side of the mounting frame 10, and the separation and purification column 40 is located on one side of the salt conversion assembly 20. Quick connectors 16 are provided at the inlet and outlet ends of the ytterbium salt conversion column 21 and the lutetium salt conversion column 22. On the mounting frame 10 above the ytterbium salt conversion column 21 and the lutetium salt conversion column 22, cylinders 15 are fixed, the number of which is equal to and corresponds one by one to the number of quick connectors 16 at each inlet end. On the mounting frame 10 below the ytterbium salt conversion column 21 and the lutetium salt conversion column 22, cylinders 15 are fixed, the number of which is equal to and corresponds one by one to the number of quick connectors 16 at each outlet end. The cylinders 15 control the opening and closing of the corresponding quick connectors 16, thereby realizing the connection or disconnection between the ytterbium salt conversion column 21, the lutetium salt conversion column 22 and the pipeline. The valve assembly 30 and the sample injection system 50 are respectively installed on the rear side of the mounting frame 10. The fraction assembly 60 includes a lutetium fraction tank 61 and a ytterbium fraction tank 62. The lutetium fraction tank 61 is installed on the mounting frame 10 or arranged on one side of the mounting frame 10, and the ytterbium fraction tank 62 is arranged on one side of the mounting frame 10 or installed on the mounting frame 10. The waste liquid assembly 70 includes at least one waste liquid tank, and the waste liquid tank is installed on the mounting frame 10 or arranged on one side of the mounting frame 10. A gamma-ray spectrometer detection probe 80 is provided on the front side of the mounting frame 10, and an ultraviolet detector 90 is provided on the mounting frame 10 below the valve assembly 30. Ultraviolet detectors 90 and reaction tubes 100 are respectively provided on the pipeline between the separation and purification column 40 and the waste liquid tank. The sample tank 54 contains the target material solution to be separated. The control terminal controls the opening and closing of the valves in the sample injection system 50 and the valve assembly 30, and controls the flow of the target material solution to be separated to the separation and purification column 40 for separating ytterbium ions and lutetium ions. After separation, the lutetium fraction containing lutetium ions is collected in the lutetium fraction tank 61, and the ytterbium fraction containing ytterbium ions is collected in the ytterbium fraction tank 62. The lutetium fraction in the lutetium fraction tank 61 is introduced into the lutetium salt conversion column 22 for lutetium salt conversion and concentration, and the ytterbium fraction in the ytterbium fraction tank 62 is introduced into the ytterbium salt conversion column 21 for ytterbium salt conversion and recovery.

[0041] It is understandable that the injection system 50, the valve assembly 30, etc. are controlled by a control terminal to control the flow of liquid in the separation and purification device, so that the separation purification column 40 separates the ytterbium-lutetium mixture to obtain an ytterbium fraction containing ytterbium ions and a lutetium fraction containing lutetium ions, and they flow into the corresponding fraction tanks in the fraction assembly 60 respectively. Then, the corresponding salt conversion assembly 20 is used to post-treat the ytterbium ions and lutetium ions to obtain the required ytterbium salt and lutetium salt, completing the separation and purification requirements of lutetium in the ytterbium-lutetium mixture and the requirement of recovering the raw material ytterbium. Among them, by reasonably arranging the salt conversion assembly 20, the valve assembly 30, the separation purification column 40, the injection system 50, the fraction assembly 60 and the waste liquid assembly 70 on and near the mounting rack 10, the various devices for separating and purifying the ytterbium-lutetium mixture are concentrated and reasonably distributed. This not only enables the device to achieve the function of separating and purifying lutetium in the ytterbium-lutetium mixture, but also makes the overall device small enough through reasonable and compact space setting and distribution. And in the specific implementation, the valves in each valve assembly 30 are all pneumatic valves, the flow of each liquid in the device is realized through pneumatic means, and the electronic components of each component are arranged outside the box body, thus enabling the components to avoid the influence of radioactive decay on the component life and ensuring the stability and reliability of the overall device. Therefore, through pneumatic full-automatic control, the entire process step does not require operator control, avoiding the influence of radiation on the operator. And by adjusting the materials and adopting a pneumatic control structure, the radiation resistance and service life of each component in the separation and purification device are greatly improved, and through the reasonable distribution and connection of each component, the volume of the separation and purification device is reduced. Specifically:

[0042] The mounting rack 10 of this embodiment includes a frame 11, a mounting plate A 12 and a mounting plate B 13. The frame 11 is the main body of the mounting rack 10. A separation and purification column 40 is installed on one side inside the frame 11, and the mounting plate A 12 and the mounting plate B 13 arranged front and back are installed on the other side inside the frame 11. The salt conversion assembly 20 is installed on the outer side of the mounting plate A 12, and the valve assembly 30 and the sample injection system 50 are installed on the outer side of the mounting plate B 13. During specific implementation, the space inside the frame 11 is reasonably partitioned and used to set the separation and purification column 40, the mounting plate A 12 and the mounting plate B 13 respectively. Then, by reasonably adjusting the space on the mounting plate A 12 and the mounting plate B 13, they are respectively used to set the salt conversion assembly 20, the sample injection system 50 and the valve assembly 30, so that the irregular components are arranged on the regular frame 11 through reasonable distribution, making rational and effective use of the space and greatly reducing the floor area of the overall device. In addition, a sample tank 54 and a finished product tank are arranged between the mounting plate A 12 and the mounting plate B 13. The sample injection system 50 is connected to the sample tank 54, the six-way sample injection valve 52, the sample injection pump 51 and the feeding equipment through pipelines; that is, the six-way sample injection valve 52 with a quantitative loop 53 is respectively connected to the reagent tank D4, the sample tank 54, the separation and purification column 40 and the third waste liquid tank 73 through pipelines. A sample injection pump 51 is provided on the pipeline connected to the third waste liquid tank 73, and a heat exchanger 9 is provided on the pipeline connected to the reagent tank D4. In addition, during specific implementation, the finished product tank includes a ytterbium finished product tank 63 and a lutetium finished product tank 64. The carrier-free lutetium-177 obtained by lutetium salt conversion and concentration is discharged into the lutetium finished product tank 64, and the solution recovered by ytterbium salt conversion is discharged into the ytterbium finished product tank 63. By arranging the sample tank 54 and the finished product tank between the mounting plate A 12 and the mounting plate B 13, the space inside the mounting rack 10 is utilized as much as possible.

[0043] In this embodiment, a material replacement tray 14 is provided at the bottom of the mounting rack 10, and the material replacement tray 14 is used to hold replacement parts. Specifically, a salt conversion column, the separation and purification column 40, valves, etc. can be placed on the material replacement tray 14. A manipulator is used to replace, disassemble and repair these components. By way of example and not limitation, in some alternative embodiments, the material replacement tray 14 is in the form of a seesaw. The replacement part is placed at one end, and then the manipulator holds it at the other end, and the part moves closer to the manipulator, and then the manipulator picks it up for replacement.

[0044] The valve assemblies 30 in this embodiment are all pneumatic valves, including a plurality of uniformly distributed three-way valves 32 and a plurality of one-position multi-way valves 31 arranged on one side of all the three-way valves 32. In specific implementation, the relative positions of the three-way valves 32 and the one-position multi-way valves 31 can be adjusted according to the specific installation conditions to ensure the reasonable application of space. By setting a plurality of different valves, the flow of the liquid in the device is controlled to ensure the stable and accurate operation of the production process. Specifically, an energy spectrum detection probe 80 is provided on one side of the mounting rack 10 close to the salt conversion assembly 20, and an ultraviolet detector 90 is provided below the valve assembly 30. The energy spectrum detection probe 80 and the ultraviolet detector 90 are used to monitor the outflow time of each product in the device to assist the operation of the valve assembly 30 and the sampling system 50. In addition, a temperature sensor B is also provided on the separation and purification column 40, and the temperature sensor B is used to detect the temperature of the separation and purification column 40 to ensure that the separation and purification column 40 operates in an optimized temperature range. In addition, the installation positions of the energy spectrum detection probe 80 and the ultraviolet detector 90 can also be adjusted according to the actual situation to rationalize the use of space, which is not limited. The three-way valves in this embodiment include a three-way valve A320 at the input end of the separation and purification column 40, a three-way valve B321 at the output end of the separation and purification column 40, a three-way valve C322 at the input end of the ytterbium salt conversion column 21, a three-way valve D323 at the output end of the ytterbium salt conversion column 21, a three-way valve E324 at the input end of the lutetium salt conversion column, a three-way valve F325 at the output end of the lutetium salt conversion column, a three-way valve G326 on the pipeline between the three-way valve D323 and the ytterbium finished product tank 63, a three-way valve H327 on the pipeline between the three-way valve 325F and the lutetium finished product tank 64, a three-way valve I328 connected to the reagent tank A1 through a pipeline, and a three-way valve J329 connected to the reagent tank B2 through a pipeline. The one-position multi-way valves in this embodiment include a one-position four-way valve 311 on the pipeline between the three-way valve B321 and the ytterbium fraction tank 62, and a one-position six-way valve A312 at the input end of each lutetium fraction tank 61 and a one-position six-way valve B313 at the output end of each lutetium fraction tank 61.

[0045] In this embodiment, there are two separation and purification columns 40 arranged side by side. A three-way valve A320 is provided at the input ends of the two separation and purification columns 40. The first interface of the three-way valve A320 is connected to the six-port injection valve 52 through a pipeline, and the second interface and the third interface are respectively connected to the input ends of the two separation and purification columns 40. A three-way valve B321 is provided at the output ends of the two separation and purification columns 40. The first interface of the three-way valve B321 branches out two branches. One branch goes through the reactor 100 and the ultraviolet detector 90 and then reaches the third waste liquid tank 73, and the other branch goes through the energy spectrum detection probe A801 and the one-way four-port valve 311 and then reaches the ytterbium fraction tank 62. The second interface and the third interface of the three-way valve B321 are respectively connected to the output ends of the two separation and purification columns 40. The other two interfaces of the one-way four-port valve 311 are respectively connected to the third waste liquid tank 73 and the input end of the one-way six-port valve A312 through pipelines. The packing in the separation and purification column 40 of this embodiment can adopt the packing prepared in Example 1 of the patent with the publication number of CN102614845A and published on August 1, 2012.

[0046] In this embodiment, five lutetium fraction tanks 61 and one ytterbium fraction tank 62 are provided. The five lutetium fraction tanks 61 are all arranged at the top of the mounting rack 10, and one ytterbium fraction tank 62 is arranged on one side of the mounting rack 10. In specific implementation, the ytterbium-lutetium mixture in the sample tank 54 is introduced into the quantitative loop 53 to determine the amount of the ytterbium-lutetium mixture separated and purified each time. By providing five lutetium fraction tanks 61, when the ytterbium-lutetium mixture in a sample tank 54 enters the quantitative loop 53 in sequence for multiple separations and purifications, the lutetium ions separated each time can be stored separately to ensure the independence of each separation and purification, thereby preventing errors and avoiding the mutual influence of different rounds of separations. A one-way six-port valve A312 is provided at the input ends of the five lutetium fraction tanks 61 and the first waste liquid tank 71. The input end of the one-way six-port valve A312 is respectively connected to the reagent tank A1 and the one-way four-port valve 311 through pipelines. A one-way six-port valve B313 is provided at the output ends of the five lutetium fraction tanks 61 and the first waste liquid tank 71. The output end of the one-way six-port valve B313 is connected to the lutetium salt conversion column 22 through a pipeline.

[0047] The waste liquid assembly 70 of this embodiment includes a first waste liquid tank 71, a second waste liquid tank 72, and a third waste liquid tank 73. The first waste liquid tank 71 is arranged on one side of the top of the mounting rack 10 near the ytterbium fraction tank 62. The second waste liquid tank 72 and the third waste liquid tank 73 are respectively arranged on one side of the mounting rack 10. The ytterbium fraction tank 62 is arranged on the top of the second waste liquid tank 72. The third waste liquid tank 73 is used to collect the waste water during separation and when cleaning the whole device before and after separation. Therefore, the amount of waste water is large, and thus the third waste liquid tank 73 is also large, so it is set separately. The second waste liquid tank 72 and the first waste liquid tank 71 are used to collect the waste liquid during the lutetium salt conversion and ytterbium salt conversion processes. The second waste liquid tank 72 can be used to collect the waste liquid during the ytterbium salt conversion process, and the first waste liquid tank 71 can be used to collect the waste liquid during the lutetium salt conversion process. Or both the second waste liquid tank 72 and the first waste liquid tank 71 can be used to collect the waste liquid during the ytterbium salt conversion process or both can be used to collect the waste liquid during the lutetium salt conversion process. Since the amount of waste liquid during the lutetium salt conversion and ytterbium salt conversion processes is small, the volumes of the second waste liquid tank 72 and the first waste liquid tank 71 are small. Therefore, the second waste liquid tank 72 is arranged at the bottom of the ytterbium fraction tank 62, and the first waste liquid tank 71 is arranged on one side of the top of the mounting rack 10 near the ytterbium fraction tank 62. Furthermore, according to the volume size, the position distribution of each waste liquid tank is reasonably set to reduce the floor area of the whole device. In addition, during specific implementation, by adjusting the connection of the pipeline and the control of the valve, the first waste liquid tank 71, the second waste liquid tank 72, and the third waste liquid tank 73 can be mutually replaced, and it is not limited to collecting a certain kind of waste liquid.

[0048] There are two ytterbium salt conversion columns 21 arranged side by side in this embodiment, and there are two lutetium salt conversion columns 22 arranged side by side. Two salt conversion columns are respectively installed for the salt conversion of ytterbium and lutetium, which can ensure that when one side of the salt conversion column is damaged or needs to be cleaned, there is a spare salt conversion column that can be put into use to ensure the stable operation of the production process. The ytterbium salt conversion column 21 (a PEEK chromatographic column with an inner diameter of 20 mm and a length of 150 mm) in this embodiment is filled with a strong cation exchange resin (DOWEX® 50WX8 cation exchange resin), and the lutetium salt conversion column 22 (a PEEK chromatographic column with an inner diameter of 4.6 mm and a length of 100 mm) is filled with a strong cation exchange resin (DOWEX® 50WX8 cation exchange resin).

[0049] To facilitate the replacement of the ytterbium salt column 21 and the lutetium salt column 22 by a manipulator instead of manual operation and at the same time reduce the requirements for the manipulator, in this embodiment, four quick-connect joints 16 are respectively provided at the liquid inlet ends of the two ytterbium salt columns 21 and the two lutetium salt columns 22, and four quick-connect joints 16 are also respectively provided at the liquid outlet ends of the two ytterbium salt columns 21 and the two lutetium salt columns 22. Four cylinders 15 are installed on the frame 11 above the two ytterbium salt columns 21 and the two lutetium salt columns 22, and four cylinders 15 are installed on the frame 11 below the two ytterbium salt columns 21 and the two lutetium salt columns 22. Each cylinder is connected to a control terminal, and the control terminal controls each cylinder 15 to manipulate the corresponding quick-connect joint 16 to disconnect or connect. As Figures 7 - 10As shown in the figure, the quick-connect fitting 16 of this embodiment includes a top base 1601, a top flow-through plate 1603, an upper spring 1606, a sealing ring 1607, a male fitting sleeve 1608, an upper fitting inner core 1609, a nut cover 1610, a female fitting sleeve 1611, a lower fitting inner core 1612, and a bottom flow-through plate 1613. The upper end of the top base 1601 is connected to the output end of the cylinder 15, and the lower end of the top base 1601 is threadedly connected to the upper end of the male fitting sleeve 1608 and sealed through the sealing ring 1607. The male fitting sleeve 1608 has a hollow internal structure, and the inner wall of the lower end of the hollow interior is an inclined surface that slopes inward from top to bottom. At the upper end of the hollow interior of the male fitting sleeve 1608, there is a top flow-through plate 1603. A central hole A1604 is opened in the middle of the top flow-through plate 1603, and a plurality of liquid passage holes 1605 are opened in the circumferential direction around the central hole A1604. A liquid inlet B1602 for connecting to a pipeline is radially opened on the top base 1601. The liquid inlet B1602 of the quick-connect fitting 16 at the liquid inlet end of the ytterbium rotation salt column 21 is connected to the three-way valve C322 through a pipeline, the liquid inlet B1602 of the quick-connect fitting 16 at the liquid outlet end of the ytterbium rotation salt column 21 is connected to the three-way valve D323 through a pipeline, the liquid inlet B1602 of the quick-connect fitting 16 at the liquid inlet end of the lutetium rotation salt column 22 is connected to the three-way valve E324 through a pipeline, and the liquid inlet B1602 of the quick-connect fitting 16 at the liquid outlet end of the lutetium rotation salt column 22 is connected to the three-way valve F325 through a pipeline. The liquid inlet B1602 is communicated with the upper ends of the respective liquid passage holes 1605 through the hole passage inside the top base 1601, and the lower ends of the respective liquid passage holes 1605 are communicated with the interior of the male fitting sleeve 1608. The central hole A1604 on the top flow-through plate 1603 axially penetrates the top flow-through plate 1603, and the central hole A1604 is a stepped hole. The upper fitting inner core 1609 is floatingly accommodated inside the male fitting sleeve 1608. An upper spring 1606 is sleeved on the upper fitting inner core 1609. The upper end of the upper spring 1606 abuts against the lower surface of the top flow-through plate 1603, and the lower end of the upper spring 1606 abuts against the boss on the upper fitting inner core 1609. The upper end of the upper fitting inner core 1609 is inserted into the central hole A1604 of the top flow-through plate 1603. The lower end of the upper fitting inner core 1609 abuts against the inclined surface at the lower end of the hollow interior of the male fitting sleeve 1608 under the action of the upper spring 1606. A sealing ring 1607 is also provided at the lower end of the upper fitting inner core 1609. When the quick-connect fitting 16 is in the disconnected state, the upper fitting inner core 1609 is sealed with the inclined surface at the lower end of the hollow interior of the male fitting sleeve 1608 through the sealing ring 1607.

[0050] The female joint sleeve 1611 is connected to the inlet and outlet ends of the ytterbium transfer salt column 21 or the lutetium transfer salt column 22. The nut cover 1610 is threadedly connected to the upper end of the female joint sleeve 1611 and is sealed through the sealing ring 1607. The lower end of the female joint sleeve 1611 is threadedly connected to the bottom flow-through plate 1613 located inside the inlet and outlet ends of the ytterbium transfer salt column 21 or the lutetium transfer salt column 22. The bottom flow-through plate 1613 has a hollow internal structure, and a central hole B1614 is provided at the bottom. The inner wall of the upper end of the hollow interior is an inclined surface that slopes inward from bottom to top. The lower joint inner core 1612 is floatingly accommodated inside the female joint sleeve 1611. A lower spring 1615 is sleeved on the lower joint inner core 1612. The lower end of the lower spring 1615 abuts against the bottom surface of the hollow interior of the bottom flow-through plate 1613. The upper end of the lower spring 1615 abuts against the boss on the lower joint inner core 1612. The lower end of the lower joint inner core 1612 is inserted into the central hole B1614 of the bottom flow-through plate 1613. The upper end of the lower joint inner core 1612 abuts against the inclined surface at the upper end of the hollow interior of the female joint sleeve 1611 under the action of the lower spring 1615. When the quick-connect joint 16 is in the disconnected state, the lower joint inner core 1612 is sealed with the inclined surface at the upper end of the hollow interior of the female joint sleeve 1611 through the sealing ring 1607.

[0051] The control terminal controls the cylinder 15 to work. The cylinder 15 drives the top base 1601 and the male joint sleeve 1608 to move towards the female joint sleeve 1611 until the male joint sleeve 1608 is in sealing contact with the female joint sleeve 1611, thereby realizing the connection of the quick-connect joint 16 at the inlet and outlet ends. The lower end of the upper joint inner core 1609 abuts against the upper end of the lower joint inner core 1612, and the channels are connected under the action of the upper spring 1606 and the lower spring 1615. The liquid entering from the liquid inlet B1602 of the liquid inlet end quick-connect joint 16 flows through the liquid passage hole 1605, inside the male joint sleeve 1608, inside the nut cover 1610, and inside the female joint sleeve 1611 in sequence and then flows into the inside of the bottom flow-through plate 1613. Finally, it flows into the ytterbium transfer salt column 21 or the lutetium transfer salt column 22 through the gap between the lower end of the lower joint inner core 1612 and the central hole B1614. After the salt transfer, it flows out through the inside of the bottom flow-through plate 1613 of the liquid outlet end quick-connect joint 16, inside the female joint sleeve 1611, inside the nut cover 1610, inside the male joint sleeve 1608, the liquid passage hole 1605, and the liquid inlet B1602.

[0052] In this embodiment, a reagent tank A1, a reagent tank B2, a reagent tank C3, and a reagent tank D4 are respectively provided. Pumps A5, B6, C7, and D8 are respectively provided on the outlet pipelines of the reagent tank A1, the reagent tank B2, the reagent tank C3, and the reagent tank D4.

[0053] By way of example and not limitation, in some alternative embodiments, the specific use process of the present invention is as follows:

[0054] First, control the mobile phase (such as eluent or rinsing agent) in reagent tank D4 through the sampling system 50 to rinse the entire device at a preset flow rate. The flow path is as follows: The feeding device conveys the mobile phase, which is heated by the heat exchanger 9 and then enters any separation and purification column 40 through the sampling system 50, six-port sampling valve 52, and three-way valve A320. After flowing out through the three-way valve B321, it is divided into two branches. A small branch (less than 3% of the total flow rate) flows through the reaction tube 100 to react with the color reagent and then flows into the ultraviolet detector 90. After detection, it is discharged into the third waste liquid tank 73 for waste liquid treatment. The main branch (more than 97% of the total flow rate) is detected by the energy spectrum detection probe A801 and then discharged into the third waste liquid tank 73 through the one-way four-way valve 311. In this embodiment, the reagent tank C3 contains the color reagent, and the color reagent in the reagent tank C3 is continuously conveyed to the reaction tube 100 by the pump C7.

[0055] As Figures 11 - 15 shown, the heat exchanger 9 in this embodiment includes a housing 901, a heating rod 904, a temperature sensor A905, a coil rack 906, and a heat exchange coil 907. The housing 901 is filled with a heat-conducting medium (the heat-conducting medium in this embodiment can be water or heat-conducting oil). The top of the housing 901 is respectively provided with a liquid inlet A902 and a liquid outlet 903. A coil rack 906 is installed inside the housing 901, and a heat exchange coil 907 is spirally wound on the coil rack 906. The two ends of the heat exchange coil 907 are respectively communicated with the liquid inlet A902 and the liquid outlet 903. Inside the coil rack 906, there are respectively a heating rod 904 and a temperature sensor A905. The heating rod 904, temperature sensor A905, coil rack 906, and heat exchange coil 907 are all immersed in the heat-conducting medium. The upper ends of the heating rod 904 and the temperature sensor A905 are fixed on the housing 901. The heating rod 904 is energized to heat the heat-conducting medium. The mobile phase flows into the heat exchange coil 907 from the liquid inlet A902 and exchanges heat with the heated heat-conducting medium during the process of flowing through the heat exchange coil 907. The exchanged mobile phase flows out from the liquid outlet 903.

[0056] The control terminal controls the switching of the six-port injection valve 52, so that the ytterbium-lutetium mixture in the sample tank 54 is drawn into the quantitative loop 53. Then, the six-port injection valve 52 is switched again, and the mobile phase in the reagent tank D4 is drawn in by the injection pump 51. The sample can then be carried into the separation and purification column 40 by the mobile phase, and the separation process officially begins. The final destination of the main flow path depends on the signals of the energy spectrum detection probe A801 and the ultraviolet detector 90. According to the signals provided by the energy spectrum detection probe A801 and the ultraviolet detector 90, the switching of the one-way four-port valve 311 is controlled. When the signal of lutetium is detected, it flows through the one-way six-port valve A312 to the lutetium fraction tank 61 (due to the limited space of the hot cell, in this embodiment, separation can be performed at most five times. To prevent errors, the lutetium fractions are collected separately each time, so five lutetium fraction tanks 61 are equipped. The number of lutetium fraction tanks does not affect the implementation of this separation process); when the signal of ytterbium is detected, it flows to the ytterbium fraction tank 62; in other cases, it flows to the third waste liquid tank 73. After the separation is completed, the separation and purification column 40 can be cleaned and preserved with 10% - 100% methanol; it is also possible not to preserve it, and it can be decided according to the characteristics of the separation and purification column 40 by oneself.

[0057] The separated lutetium fraction contains an organic acid eluent and does not meet the final use requirements. Therefore, a salt conversion and concentration step for lutetium is required. This step can not only remove the eluent and convert it into the form of lutetium chloride solution suitable for medical use, but also play the role of concentrating the lutetium product (the separated lutetium fraction is very dilute). Specifically:

[0058] Device replacement: The water in reagent tank B2 is used to replace the preservation solution in the device through a feeding device. It flows through three-way valve J329, three-way valve E324, lutetium transfer salt column 22, three-way valve F325, energy spectrum detection probe B802, three-way valve H327, and one-six-way valve A312 and then drains into the first waste liquid tank 71; Sample preparation: 2M hydrochloric acid in reagent tank A1 is sequentially pumped into the lutetium fraction tank 61 containing lutetium fraction through one-six-way valve A312, and then the liquid is evenly mixed by gas stirring; Loading: The liquid in the above lutetium fraction tank 61 is loaded into the lutetium transfer salt column 22 through one-six-way valve B313 and three-way valve E324 in sequence, and lutetium ions are adsorbed in the lutetium transfer salt column 22. If a pump is used for loading, radiation will damage the circuit board of the pump, resulting in device failure. Considering radiation protection, gas pressure feeding is selected for loading in this device, and liquid transfer can also be carried out by a pump; Elution: Water in reagent tank B2 is used to elute the residual organic acid eluent in the lutetium transfer salt column 22 through three-way valve J329 and three-way valve E324. The waste liquid drains into the first waste liquid tank 71 through three-way valve F325, three-way valve H327, and one-six-way valve A312; Elution: Manually replace reagent tank A1 with 0.15 mM hydrochloric acid. Pump 0.15 mM hydrochloric acid into the lutetium transfer salt column 22 through pump A5, three-way valve I328, and three-way valve E324. Use 0.15 mM hydrochloric acid to wash down the lutetium ions adsorbed in the lutetium transfer salt column 22 to obtain a concentrated lutetium chloride solution, which is then collected in the lutetium finished product tank 64 after passing through three-way valve F325 and three-way valve H327; After the lutetium transfer salt concentration is completed, the product can be transferred to the required place; According to requirements, the lutetium transfer salt column 22 is regenerated and preserved.

[0059] The separated ytterbium fraction contains organic acid eluent, which is not conducive to precipitation recovery. Therefore, a salt conversion and concentration step for ytterbium is required. Through this step, the eluent can be removed and converted into ytterbium chloride solution, which is convenient for subsequent further precipitation and calcination into ytterbium oxide (for recycling as a target material raw material). Specifically:

[0060] Device replacement: The preservation solution in the device is replaced with water in reagent tank B2 through a feeding device. The water flows through three-way valve J329, three-way valve C322, ytterbium conversion salt column 21, three-way valve D323, and three-way valve G326 and then drains into the second waste liquid tank 72; Sample preparation: 2M hydrochloric acid in reagent tank A1 is pumped into ytterbium fraction tank 62 containing ytterbium fraction by pump A5, and then the liquid is evenly mixed by gas stirring; Loading: The liquid in the above ytterbium fraction tank 62 is loaded into the ytterbium conversion salt column 21 through three-way valve J329 and three-way valve C322, so that ytterbium ions are adsorbed in the ytterbium conversion salt column 21; Elution: Water in reagent tank B2 is passed through three-way valve J329 and three-way valve C322 into the ytterbium conversion salt column 21 to remove the residual organic acid eluent in the ytterbium conversion salt column 21. The waste liquid drains into the second waste liquid tank 72 through three-way valve D323 and three-way valve G326; Elution: Reagent tank A1 is manually replaced with 0.15 mM hydrochloric acid. 0.15 mM hydrochloric acid is pumped into the ytterbium conversion salt column 21 through three-way valve I328 and three-way valve C322 by pump A5. The ytterbium ions adsorbed in the ytterbium conversion salt column 21 are eluted with 0.15 mM hydrochloric acid, and a high-purity ytterbium chloride solution is obtained. Then it is collected in the ytterbium finished product tank 63 after passing through three-way valve D323 and three-way valve G326. After the ytterbium conversion salt recovery is completed, the product is transferred to the required place, and then the processes such as precipitation and calcination are continued to obtain ytterbium oxide powder. According to the requirements, the ytterbium conversion salt column 21 is regenerated and preserved.

[0061] In addition, the control terminal at least includes a processor and a memory. Among them, the processor can be a central processing unit (CPU), a controller, a microcontroller, a microprocessor, or other data processing chips in some embodiments, and is used to run the program code stored in the memory or process data, such as executing an access restriction program, etc. Among them, the memory at least includes one type of readable storage medium, and the readable storage medium includes flash memory, hard disk, multimedia card, card-type memory (such as SD or DX memory, etc.), magnetic memory, magnetic disk, optical disc, etc. The memory can be an internal storage unit of an electronic device in some embodiments, such as the hard disk of the electronic device. The memory can also be an external storage device of the electronic device in other embodiments, such as a plug-in hard disk equipped on the electronic device, a smart media card (SMC), a secure digital (SD) card, a flash card, etc. Further, the memory can also include both the internal storage unit and the external storage device of the electronic device. The memory can not only be used to store the application software and various data of the electronic device, but also be used to temporarily store the data that has been output or will be output.

[0062] In addition, the device of the present invention further includes a seal, which is used for sealing the components inside the device of the present invention, and the material of the seal is a radiation-resistant material. By way of example and not limitation, in some alternative embodiments, seals are usually provided at the joints or pneumatic valves of the device of the present invention. Thus, by using a radiation-resistant material for the seals, the service life of these components can be effectively extended. It should be noted that from the above device usage process, it can be seen that the present invention realizes the full-automatic separation and purification function of ytterbium-lutetium mixture by reasonably automatically controlling the opening and closing of the valves and the flow of the liquid, enabling the device to operate fully automatically, avoiding irradiation of the staff, and improving production efficiency. In addition, the device of the present invention adopts an integrated design, enabling full-automatic operation to be achieved in a smaller space, reducing the cost of large-scale automatic control, and making the automatic control of the present invention conform to the actual production cost situation. Additionally, to avoid the impact of irradiation on the device life, the design and processing of the present invention fully consider the radiation resistance. For example, the sealing ring is changed from ordinary polytetrafluoroethylene rubber to ethylene propylene diene monomer rubber, the electronic control mechanism inside the device is replaced with a pneumatic control mechanism, and the liquid path transfer inside the hot cell is controlled by air pressure.

[0063] In summary, for a separation and purification device in the above embodiments of the present invention, the sampling system 50, the valve assembly 30, etc. are controlled by a control terminal to control the flow of the liquid in the separation and purification device, enabling the separation purification column 40 to separate the ytterbium-lutetium mixture, obtaining fractions containing ytterbium ions and lutetium ions and flowing into the corresponding fraction tanks in the fraction assembly 60 respectively, and then performing post-treatment on the ytterbium ions and lutetium ions through the corresponding salt conversion assembly 20 to obtain the required ytterbium salt and lutetium salt, thus completing the separation and purification requirements of lutetium in the ytterbium-lutetium mixture and the requirement for the recovery of the raw material ytterbium. Among them, by reasonably arranging the salt conversion assembly 20, the valve assembly 30, the separation purification column 40, the sampling system 50, the fraction assembly 60, and the waste liquid assembly 70 on and near the mounting rack 10, the various devices for separating and purifying the ytterbium-lutetium mixture are concentrated and reasonably distributed, enabling the device to realize the function of separating and purifying lutetium in the ytterbium-lutetium mixture, and making the overall device volume small enough through reasonable and compact space setting and distribution. And in specific implementation, the valves in each valve assembly 30 are all pneumatic valves, and the flow of each liquid inside the device is realized through pneumatic means. Therefore, through pneumatic full-automatic control, the present invention enables the entire process step to be without the need for operator control, avoiding the impact of radiation on the operator, and greatly improving the radiation resistance and service life of each component inside the separation and purification device by adjusting the materials and adopting a pneumatic control structure, and reducing the volume of the separation and purification device through the reasonable distribution and connection of each component.

[0064] In the description of this specification, the description referring to terms such as "one embodiment", "some embodiments", "examples", "specific examples", or "some examples", etc. means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0065] The above-described embodiments merely represent several implementation manners of the present invention. Their descriptions are relatively specific and detailed, but should not be construed as limiting the scope of the patent of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention should be subject to the appended claims.

Claims

1. A device for separation and purification of carrier-free lutetium-177, characterized in that: The invention comprises a mounting frame (10), a salt conversion assembly (20), a valve assembly (30), a separation and purification column (40), a sample injection system (50), a fraction assembly (60), a waste liquid assembly (70), a sample tank (54) and a finished product tank, wherein the salt conversion assembly (20) comprises an ytterbium salt conversion column (21) and a lutetium salt conversion column (22), the ytterbium salt conversion column (21), the lutetium salt conversion column (22) and the separation and purification column (40) are respectively mounted on the front side of the mounting frame (10), and the separation and purification column (40) is located on one side of the salt conversion assembly (20); the liquid inlet and outlet ends of the ytterbium salt conversion column (21) and the lutetium salt conversion column (22) are both provided with quick-connect joints (16); the ytterbium salt conversion column (21) and the lutetium salt conversion column (22) are ... The mounting frame (10) above the ytterbium-converted salt column (21) and the lutetium-converted salt column (22) is fixed with cylinders (15) of the same number and one-to-one correspondence as the quick-connect joints (16) at the liquid inlet end; the mounting frame (10) below the ytterbium-converted salt column (21) and the lutetium-converted salt column (22) is fixed with cylinders (15) of the same number and one-to-one correspondence as the quick-connect joints (16) at the liquid outlet end; the cylinders (15) control the switches of the corresponding quick-connect joints (16), thereby realizing the connection or disconnection between the ytterbium-converted salt column (21) and the lutetium-converted salt column (22) and the pipeline; the valve assembly (30) and the injection system (50) are respectively mounted on the rear side of the mounting frame (10); the fraction assembly (60) comprises A lutetium fraction tank (61) and an ytterbium fraction tank (62), wherein the lutetium fraction tank (61) is mounted on a mounting frame (10) or arranged on one side of the mounting frame (10), and the ytterbium fraction tank (62) is arranged on one side of the mounting frame (10) or mounted on the mounting frame (10); the waste liquid assembly (70) comprises at least one waste liquid tank, wherein the waste liquid tank is mounted on the mounting frame (10) or arranged on one side of the mounting frame (10); an energy spectrum detection probe (80) is arranged on the front side of the mounting frame (10), an ultraviolet detector (90) is arranged on the mounting frame (10) below the valve assembly (30), and a separation and purification column (40) is arranged on the pipeline between the separation and purification column (40) and the waste liquid tank. A UV detector (90) and a reaction tube (100) are separately provided; the sample tank (54) contains a target material solution to be separated; the control terminal controls the on / off of the valve in the sample injection system (50) and the valve assembly (30) to control the target material solution to be separated to flow to the separation and purification column (40) to separate ytterbium ions and lutetium ions; the lutetium fraction containing lutetium ions after separation is collected in the lutetium fraction tank (61); the ytterbium fraction containing ytterbium ions after separation is collected in the ytterbium fraction tank (62); the lutetium fraction in the lutetium fraction tank (61) is introduced into the lutetium transsalt column (22) for lutetium transsalt concentration; and the ytterbium fraction in the ytterbium fraction tank (62) is introduced into the ytterbium transsalt column (21) for ytterbium transsalt recovery.

2. The device for separation and purification of carrier-free lutetium-177 according to claim 1, characterized in that: The mounting frame (10) comprises a frame (11), a mounting plate A (12), and a mounting plate B (13); the frame (11) is the main body of the mounting frame (10); a separation and purification column (40) is mounted on one side of the frame (11); and a mounting plate A (12) and a mounting plate B (13) arranged in front and behind are mounted on the other side of the frame (11); the salt conversion assembly (20) is mounted on the outward side of the mounting plate A (12); and the valve assembly (30) and the injection system (50) are mounted on the outward side of the mounting plate B (13); and the sample tank (54) and the finished product tank are respectively arranged between the mounting plate A (12) and the mounting plate B (13).

3. The device for separation and purification of carrier-free lutetium-177 according to claim 1, characterized in that: A material replacement tray (14) for containing parts is provided at the bottom of the mounting frame (10).

4. The device for separation and purification of carrier-free lutetium-177 according to claim 1, characterized in that: The lutetium fraction tank (61) is one or more and is installed on the top of the mounting frame (10), and the ytterbium fraction tank (62) is arranged on one side of the mounting frame (10).

5. The device for separation and purification of carrier-free lutetium-177 according to claim 1, characterized in that: The waste liquid assembly (70) comprises a first waste liquid tank (71), a second waste liquid tank (72) and a third waste liquid tank (73); the first waste liquid tank (71) is mounted on the top of a mounting frame (10); the second waste liquid tank (72) and the third waste liquid tank (73) are respectively arranged on one side of the mounting frame (10); and the ytterbium fraction tank (62) is arranged on the top of the second waste liquid tank (72).

6. The device for separation and purification of carrier-free lutetium-177 according to claim 1, characterized in that: The ytterbium-converted salt column (21) is one or a plurality of columns arranged side by side, and the lutetium-converted salt column (22) is one or a plurality of columns arranged side by side.

7. The device for separation and purification of carrier-free lutetium-177 according to claim 1, characterized in that: The injection system (50) comprises an injection pump (51) and a six-way injection valve (52) with a quantitative loop (53); the six-way injection valve (52) is connected to a sample tank (54), a separation and purification column (40), a waste liquid tank and a mobile phase through pipelines, respectively; and the injection pump (51) is arranged on the pipeline.

8. The device for separation and purification of carrier-free lutetium-177 according to claim 1, characterized in that: The finished product tank comprises an ytterbium finished product tank (63) and a lutetium finished product tank (64). The carrier-free lutetium-177 obtained by lutetium transsalting and concentration is discharged into the lutetium finished product tank (64), and the solution recovered by ytterbium transsalting is discharged into the ytterbium finished product tank (63).

9. The device for separation and purification of carrier-free lutetium-177 according to claim 1, characterized in that: The device is cleaned before separation and purification, and the mobile phase transported by the feeding device is heated by the heat exchanger (9) and then enters the device; the heat exchanger (9) comprises a shell (901), a heating rod (904), a temperature sensor A (905), a coil rack (906) and a heat exchange coil (907); a heat-conducting medium is filled in the shell (901); a liquid inlet A (902) and a liquid outlet (903) are respectively provided on the top of the shell (901); a coil rack (906) is installed inside the shell (901); a heat exchange coil (907) is wound around the coil rack (906); two ends of the heat exchange coil (907) are respectively connected to the liquid inlet A (902) and the liquid outlet (903) is connected; a heating rod (904) and a temperature sensor A (905) are respectively provided inside the coil rack (906); the heating rod (904), the temperature sensor A (905), the coil rack (906) and the heat exchange coil (907) are all immersed in a heat-conducting medium; the upper ends of the heating rod (904) and the temperature sensor A (905) are fixed on the housing (901); the heating rod (904) is energized to heat the heat-conducting medium; the mobile phase flows into the heat exchange coil (907) from the liquid inlet A (902), exchanges heat with the heated heat-conducting medium in the process of flowing through the heat exchange coil (907), and the mobile phase after heat exchange flows out from the liquid outlet (903).

10. The device for separation and purification of carrier-free lutetium-177 according to claim 1, characterized in that: The quick-connect joint (16) comprises a top base (1601), a top flow plate (1603), an upper spring (1606), a joint male sleeve (1608), an upper joint inner core (1609), a nut cover (1610), a joint female sleeve (1611), a lower joint inner core (1612) and a bottom flow plate (1613). The upper end of the top base (1601) is connected to the output end of the cylinder (15), the lower end of the top base (1601) is sealed to the upper end of the joint male sleeve (1608), and the joint male sleeve (1608) is The inner wall of the lower end of the hollow interior is an inclined surface, the interior of the joint male sleeve (1608) is provided with a top flow plate (1603), the upper joint inner core (1609) is accommodated in the joint male sleeve (1608) in a floating state, the upper joint inner core (1609) is provided with an upper spring (1606), the upper end of the upper joint inner core (1609) is inserted into the center hole A (1604) of the top flow plate (1603), and the lower end is connected to the lower end of the hollow interior of the joint male sleeve (1608) under the action of the upper spring (1606). The inclined surfaces are abutted, the top flow plate (1603) is provided with a liquid flow hole (1605), and the top base (1601) is provided with a liquid inlet B (1602) connected to the liquid flow hole (1605); the female joint sleeve (1611) is connected to the liquid inlet and outlet ends of the ytterbium salt column (21) or the lutetium salt column (22), the nut cover (1610) is sealedly connected to the upper end of the female joint sleeve (1611), and the lower end of the female joint sleeve (1611) is connected to the bottom flow plate (1603) located in the liquid inlet and outlet ends of the ytterbium salt column (21) or the lutetium salt column (22). 1613) threaded connection, the bottom flow plate (1613) is an internal hollow structure, the upper inner wall of the hollow interior is an inclined surface, the lower joint inner core (1612) is accommodated in the joint female sleeve (1611) in a floating state, the lower joint inner core (1612) is sleeved with a lower spring (1615), the lower end of the lower joint inner core (1612) is inserted into the center hole B (1614) of the bottom flow plate (1613), and the upper end abuts against the inclined surface of the upper end of the hollow interior of the joint female sleeve (1611) under the action of the lower spring (1615);The cylinder (15) drives the top base (1601) and the joint male sleeve (1608) to move toward the joint female sleeve (1611) until the joint male sleeve (1608) and the joint female sleeve (1611) are sealed and abutted, thereby realizing the connection between the quick-connect joint (16) at the liquid inlet and outlet ends, and the lower end of the upper joint inner core (1609) abuts against the upper end of the lower joint inner core (1612), and the liquid flows through the liquid inlet port B (1602) of the quick-connect joint (16) at the liquid inlet end, the liquid outlet hole (1605), the inside of the joint male sleeve (1608), and the nut cover in sequence. (1610), the inside of the female joint sleeve (1611) to the inside of the bottom flow plate (1613), and finally flows into the ytterbium salt column (21) or the lutetium salt column (22) through the gap between the lower end of the lower joint inner core (1612) and the center hole B (1614), and then flows out through the inside of the bottom flow plate (1613) of the quick-connect joint (16) at the liquid outlet end, the inside of the female joint sleeve (1611), the inside of the nut cover (1610), the inside of the male joint sleeve (1608), the liquid outlet hole (1605), and the liquid inlet B (1602). ;

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