Craniocerebral injury device for animal translation, rotation and combination thereof

Abstract

The invention discloses a craniocerebral injury device for animal translation, rotation and combination thereof, comprising: a support device which is symmetrically provided with a longitudinal first translation rolling groove and a longitudinal second translation rolling groove at an interval; the brake is arranged in the first translation rolling groove in a sliding manner, and a centrosymmetric brake groove is formed in the brake; one end of the animal fixing device is rotatably arranged in the brake groove, and the other end of the animal fixing device is selectively arranged in the second translation rolling groove in a sliding and / or rotating manner; the impacting device is vertically arranged on the animal fixing device, and one end of the impacting device is selectively pressed on the animal parietal bone; the impact force arm is integrally arranged on one side of the top of the animal fixing device; wherein the impactor selectively impacts the other end of the impact device or the impact force arm. The animal craniocerebral injury simulation device has the characteristic of realizing simulation of animal craniocerebral injuries of different types and different degrees.

Description

Technical Field

[0001] The present invention relates to the technical field of impact injury experiments, and more specifically, the present invention relates to a craniocerebral injury device for animal translational, rotational, and combined movements. Background Art

[0002] Brain injury refers to organic damage to brain tissue caused by external forces acting on the head, often manifested as dizziness or coma. Given the ethical and technical challenges in conducting experiments on human traumatic brain injury (TBI), animal experiments, especially rat models, have become an effective alternative method.

[0003] However, in the prior art, only translational impact or rotational impact can be achieved separately, and it is impossible to precisely control the magnitude and ratio of translational and rotational accelerations or achieve their synergistic effect at the same time. It is impossible to simulate the actual brain impact situation, and generally, simulation devices have two or more power sources, and the structure is more complex, requiring more devices to be controlled. Summary of the Invention

[0004] The purpose of the present invention is to design and develop a craniocerebral injury device for animal translational, rotational, and combined movements. Through the combination of various structures, it is possible to simulate translational injury, rotational injury, or combined injury, improving the test accuracy.

[0005] The technical solution provided by the present invention is as follows:

[0006] A craniocerebral injury device for animal translational, rotational, and combined movements, comprising:

[0007] A support device, which symmetrically and spacedly is provided with longitudinal first translational rolling grooves and second translational rolling grooves; and

[0008] A brake, which is slidably arranged in the first translational rolling groove, and the brake is provided with centrally symmetric braking grooves;

[0009] An animal fixing device, one end of which is rotatably arranged in the braking groove, and the other end is selectively slidably and / or rotatably arranged in the second translational rolling groove;

[0010] An impact device, which is vertically arranged on the animal fixing device, and one end of the impact device is selectively pressed against the parietal bone of the animal;

[0011] An impact force arm, which is integrally arranged on one side of the top of the animal fixing device;

[0012] Wherein, the impactor can selectively impact on the other end of the impact device or the impact force arm.

[0013] Preferably, the support device includes:

[0014] a base; and

[0015] two sets of support frames, symmetrically arranged at two ends of the base, and longitudinal first translational rolling grooves and second translational rolling grooves are respectively arranged on the two sets of support frames along their central axes.

[0016] Preferably, a plurality of translational limiting grooves are arranged at intervals on the two sets of support frames.

[0017] Preferably, it further includes:

[0018] two limiters, respectively detachably arranged in any one of the translational limiting grooves of the two sets of support frames.

[0019] Preferably, it further includes:

[0020] a first bearing seat, which is provided with a central through hole;

[0021] two connecting rods, one ends of which are respectively fixed on two sides of the first bearing seat;

[0022] two rolling bearings, which are respectively fixed on the other ends of the two connecting rods;

[0023] Wherein, the two first rolling bearings are slidably arranged in the first translational rolling groove, and the brake is detachably arranged at one end of the first bearing seat.

[0024] Preferably, the animal fixing device includes:

[0025] an animal head fixing plate, which has a conical frustum structure, and the rear end of the animal head fixing plate is an open structure for placing the animal head;

[0026] two adjusting grooves, symmetrically arranged on two sides of the animal head fixing plate, and the adjusting grooves are arranged longitudinally;

[0027] two ear rods, which are respectively arranged in the two adjusting grooves, and the positions of the two ear rods in the two adjusting grooves are adjustable for fixing the cochlea of the animal;

[0028] a front rotating shaft, one end of which is fixed at the front end of the animal head fixing plate;

[0029] a rotating limiting rod, which vertically penetrates the other end of the front rotating shaft, and the rotating limiting rod is rotatably arranged in the braking groove;

[0030] an animal placing plate, which has a U-shaped structure, and one side of the animal placing plate is fixed at the rear end of the animal head fixing plate;

[0031] A rear rotating shaft, one end of which is fixed to the other side of the animal placement plate;

[0032] A second bearing seat, which is slidably arranged in the second translational rolling groove, and a bearing is arranged in the second bearing seat;

[0033] Wherein, the impact device is arranged on the top of the animal head fixing plate, the front rotating shaft passes through the central through hole, and the other end of the rear rotating shaft is arranged in the bearing of the second bearing seat.

[0034] Preferably, the impact device includes:

[0035] An impact rod, which vertically and detachably passes through the top of the animal head fixing plate;

[0036] A fixing cap, which has a disc structure, and the fixing cap is vertically arranged at one end of the impact rod;

[0037] An impact cap, which is vertically arranged at the other end of the impact rod.

[0038] Preferably, a plurality of weight-reducing holes are arranged on the animal head fixing plate.

[0039] Preferably, the impact cap is made of an elastic material.

[0040] Preferably, the limiter is made of a brittle material or a ductile material.

[0041] The beneficial effects of the present invention:

[0042] A craniocerebral injury device for animal translation, rotation and their combination designed and developed by the present invention can, through impact, simultaneously act on translational and rotational accelerations, truly simulate the rotational and translational accelerations caused by the deviation of the impact point from the center of gravity in a real collision scenario, can more accurately reproduce the complex traumatic brain injury mechanism, and can also more accurately observe the translational and rotational injuries occurring in the coronal plane of the head; it can not only realize the combined action of translational and rotational accelerations, but also simulate translational or rotational accelerations alone, providing more flexible experimental conditions, can more comprehensively study the effects of different injury modes on the brain, and the structure of this device is simpler than the prior art. Description of the Drawings

[0043] Figure 1 It is a schematic structural diagram of the craniocerebral injury device for animal translation, rotation and their combination of the present invention.

[0044] Figure 2 It is an assembly structural diagram of the animal fixing device of the present invention.

[0045] Figure 3Schematic structural diagram of the support frame according to the present invention.

[0046] Figure 4 Schematic assembly structure diagram of the support frame according to the present invention.

[0047] Figure 5 Schematic structural diagram of the animal fixing device according to the present invention.

[0048] Figure 6 Schematic assembly structure diagram of the brake according to the present invention.

[0049] Figure 7 Schematic structural diagram of the first bearing seat according to the present invention.

[0050] Figure 8 Schematic structural diagram of the brake according to the present invention.

[0051] Figure 9 Schematic structural diagram of the front rotating shaft according to the present invention.

[0052] Figure 10 Schematic front structure diagram of the animal head fixing plate according to the present invention.

[0053] Figure 11 Schematic rear structure diagram of the animal head fixing plate according to the present invention.

[0054] Figure 12 Schematic structural diagram of the impact device according to the present invention. Detailed implementation manners

[0055] The following further describes the present invention in detail so that those skilled in the art can implement it with reference to the text of the specification.

[0056] As Figure 1 shown, a craniocerebral injury device for animal translation, rotation and their combination provided by the present invention includes:

[0057] A support device, a brake 110, an animal fixing device 120, an impact device 130, two limiters 140 and an impactor 200.

[0058] The brake 110 can be selectively longitudinally slid or fixed in the support device. The animal fixing device 120 realizes rotation or translation through the brake 110. The impact device 130 is fixed on the animal fixing device 120 to receive the impact torque of the impactor 200. The two limiters 140 are used to limit the position of the animal fixing device 120.

[0059] Among them, the support device includes a base 101 and two groups of support frames 102, as Figure 2 , Figure 3 andFigure 4 As shown, the two sets of support frames 102 are symmetrically fixed at both ends of the base 101 by bolts, and each set includes two support frames 102. The two support frames 102 are arranged opposite to each other by bolts, so that each set of support frames 102 respectively form a first translational rolling groove 104 and a second translational rolling groove 105 along their central axes. A plurality of translational limit grooves 103 are arranged opposite to each other at intervals along the longitudinal direction on the two support frames 102 in each set of support frames 102, and different translational braking decelerations can be achieved. The two limiters 140 can be selectively inserted into any one of the translational limit grooves 103 in the two sets of support frames 102.

[0060] In this embodiment, a sponge material is provided on the top contact plane of the base 101, so that the animal fixing device 120 can achieve a soft landing.

[0061] As Figure 5 、 Figure 6 、 Figure 7 As shown, the brake 110 is slidably arranged in the first translational rolling groove 104. In this embodiment, the brake 110 is fixed to one end of the first bearing seat 161 by bolts. The first bearing seat 161 is provided with a central through hole, and connecting rods 162 are respectively fixed on both sides of the first bearing seat 161. Rolling bearings 163 are fixed at the mutually remote ends of the connecting rods 162. The two rolling bearings 163 can roll along the first translational rolling groove 104, which can reduce the friction force.

[0062] As Figure 8 As shown, the brake 110 is provided with a centrally symmetric braking groove 111.

[0063] In this embodiment, the braking groove 111 is a centrally symmetric arc structure. Different levels of damage can be achieved by setting different groove angles of the braking groove 111. For example, when the external collision energy is 10 J, 20 J or 30 J, different degrees of TBI can be reproduced. The greater the external energy, the smaller the groove angle, the greater the cranial deceleration generated, and the more serious the corresponding brain damage degree.

[0064] As Figure 9 、 Figure 10 、 Figure 11As shown in the figure, the animal fixing device includes: an animal head fixing plate 121, an animal placement plate 122, two adjustment slots (not marked in the figure), an impact force arm 123, two ear rods 124, a front rotating shaft 151, a rotation limiting rod 152, a rear rotating shaft 171, and a second bearing seat 172. The animal head fixing plate 121 has a conical frustum structure to adapt to the shape of the animal's head, and the rear end of the animal head fixing plate 121 is an open structure for connecting with the animal placement plate 122. The animal placement plate 122 has a U-shaped structure, and one end of it is fixed to the rear end of the animal head fixing plate 121 through a connecting plate, thus forming a complete animal placement structure. Two longitudinal adjustment slots are symmetrically arranged on both sides of the animal head fixing plate 121. The two ear rods 124 are composed of bolts and nuts, and the position of the ear rods 124 in the adjustment slots can be adjusted by adjusting the nuts to fix the cochlea of the animal. On one side of the top of the animal head fixing plate 121, a protruding impact force arm 123 is integrally provided. At the same time, an impact device 130 is vertically arranged on the top of the animal head fixing plate 121 to press the parietal bone of the animal. Both the impact force arm 123 and the impact device 130 are used to receive the impact moment of the impactor 200. One end of the front rotating shaft 151 is fixed to the center position of the front end of the animal head fixing plate 121 through a nut, and the other end passes through the central through hole of the first bearing seat 161. A rotation limiting rod 152 is vertically arranged at the other end of the front rotating shaft 151, and the rotation limiting rod 152 is rotatably arranged in the braking slot 111. One end of the rear rotating shaft 171 is fixed to the other end of the animal placement plate 122. The second bearing seat 172 is slidably arranged in the second translational rolling slot 105 through a bearing, and a bearing is provided in the center of the second bearing seat 172. The other end of the rear rotating shaft 171 is arranged in the bearing of the second bearing seat 172, so that the animal head fixing plate 121 and the animal placement plate 122 can achieve longitudinal translation and rotation.

[0065] As Figure 12 shown, the impact device 130 includes an impact rod 131, a fixing cap 132, and an impact cap 133. The impact rod 131 vertically and detachably passes through the top of the animal head fixing plate 121 and is fixed in position by a nut. The fixing cap 132 has a disc structure, and the fixing cap 132 is vertically arranged at one end of the impact rod 131, that is, the fixing cap 132 is arranged inside the animal head fixing plate 121. The impact cap 133 is vertically arranged at the other end of the impact rod 131, that is, the impact cap 133 is fixed outside the animal head fixing plate 121 to receive the impact moment of the impactor 200.

[0066] In this embodiment, a plurality of weight reduction holes are provided on the animal head fixing plate 121 to achieve the light weight of the device.

[0067] In this embodiment, the impact cap 133 is made of an elastic material, which can extend the impact time.

[0068] In this embodiment, the material of the limiter 140 can be selected according to the required impact type. If only translational movement of the animal is needed for injury determination, the material of the limiter 140 is a brittle material; if only rotational movement of the animal is needed for injury determination, the material of the limiter 140 is a ductile material to ensure the position of the animal head fixing plate 121.

[0069] The driving source of the impactor 200 can be electromagnetic or pneumatic.

[0070] In this embodiment, by adjusting the impact force magnitude of the impactor 200 and the length of the impact force arm 123, the magnitudes and their ratios of the translational and rotational accelerations in the experiment combining translational and rotational accelerations can be controlled.

[0071] The working process of a craniocerebral injury device for animal translational movement, rotation and their combination according to the present invention is as follows:

[0072] Place the animal on the animal placement plate 122, fix the animal body on the animal placement plate 122 by a bandage or rope, place the animal's head in the animal head fixing plate 121, adjust the impact rod 131 so that the fixing cap 132 presses tightly on the animal's parietal bone, then adjust the distance between the ear rod 124 and the animal's cochlea so that the ear rod 124 abuts against the animal's cochlea, and adjust the distance between the impactor 200 and the impact cap 133. When the impactor 200 strikes the impact cap 133 downward under the action of an external driving force, the impact force is transmitted to the animal head fixing plate 121, causing translational movement or rotation of the animal's head (when the limiter 140 is not in the upper first limiting groove 103 of the support frame 102, the animal's head makes a translational impact); when the impactor 200 strikes the impact force arm 123 downward under the action of an external driving force, the animal's head makes a rotational impact (when the limiter 140 is not in the upper first limiting groove 103 of the support frame 102, the animal's head realizes a combined movement of translational impact and rotational impact, and conversely, when the limiter 140 is in the upper first limiting groove 103 of the support frame 102, the animal can perform head rotation), and the rotation range of the rotation limiting rod 152 is limited by the braking groove 111.

[0073] A craniocerebral injury device designed and developed by the present invention for the translational, rotational and combined movements of animals can trigger the simultaneous action of translational and rotational accelerations through impact, truly simulate the rotational and translational accelerations caused by the deviation of the impact point from the center of gravity in the real collision scenario, can more accurately reproduce the complex traumatic brain injury mechanism, and can also more accurately observe the translational and rotational injuries occurring in the coronal plane of the head; it can not only achieve the combined action of translational and rotational accelerations, but also simulate translational or rotational accelerations separately, providing more flexible experimental conditions, can more comprehensively study the effects of different injury modes on the brain, and this device has a simpler structure compared with the prior art.

[0074] Although the embodiments of the present invention have been disclosed as above, it is not limited to the applications listed in the specification and embodiments. It can be fully applied to various fields suitable for the present invention. For those familiar with the field, additional modifications can be easily achieved. Therefore, without departing from the general concept defined by the claims and the equivalent scope, the present invention is not limited to the specific details and the embodiments shown and described here.

Claims

1. A device for causing craniocerebral injury to animals in translation, rotation or a combination thereof, characterized in that: include: A supporting device, which is symmetrically provided with a first longitudinal translation rolling groove and a second longitudinal translation rolling groove; as well as A brake, which is slidably disposed in the first translational rolling groove, and the brake is provided with a centrally symmetrical brake groove; An animal fixing device, one end of which is rotatably disposed in the braking groove and the other end of which is selectively slidably and / or rotatably disposed in the second translation rolling groove; An impact device, which is vertically arranged on the animal fixing device, and one end of the impact device can be selectively pressed against the animal's parietal bone; An impact force arm, which is integrally arranged on one side of the top of the animal fixing device; The impactor can selectively impact on the other end of the impact device or the impact arm.

2. The craniocerebral injury device for animal translation, rotation and combination thereof as claimed in claim 1, characterized in that: The supporting device comprises: Base; and Two groups of support frames are symmetrically arranged at two ends of the base, and the two groups of support frames are respectively provided with a longitudinal first translation rolling groove and a second translation rolling groove along their central axis.

3. The craniocerebral injury device for animal translation, rotation and combination thereof as claimed in claim 2, characterized in that: A plurality of translation limiting grooves are arranged at intervals on the two groups of support frames.

4. The craniocerebral injury device for animal translation, rotation and combination thereof as claimed in claim 3, characterized in that: Also includes: Two limiters are detachably arranged in any translation limit slot of the two groups of support frames.

5. The craniocerebral injury device for animal translation, rotation and combination thereof as claimed in claim 4, characterized in that: Also includes: A first bearing seat, which is provided with a central through hole; Two connecting rods, one end of which is respectively fixed to two sides of the first bearing seat; Two rolling bearings, which are respectively fixed on the other ends of the two connecting rods; Wherein, the two first rolling bearings are slidably arranged in the first translational rolling groove, and the brake is detachably arranged at one end of the first bearing seat.

6. The craniocerebral injury device for animal translation, rotation and combination thereof as claimed in claim 5, characterized in that: The animal fixing device comprises: The animal head fixing plate is in a conical platform structure, and the rear end of the animal head fixing plate is an open structure for placing the animal head; Two adjustment slots are symmetrically arranged on both sides of the animal head fixing plate, and the adjustment slots are arranged in the longitudinal direction; Two ear rods, which are respectively arranged in the two adjustment grooves, and the positions of the two ear rods in the two adjustment grooves are adjustable, and are used to fix the cochlea of ​​the animal; A front rotating shaft, one end of which is fixed to the front end of the animal head fixing plate; A rotation limiting rod, which vertically passes through the other end of the front rotation shaft, and the rotation limiting rod is rotatably arranged in the braking groove; An animal placement board having a U-shaped structure, and one side of the animal placement board is fixed to the rear end of the animal head fixing board; a rear rotating shaft, one end of which is fixed to the other side of the animal placement board; a second bearing seat, which is slidably disposed in the second translation rolling groove, and a bearing is disposed in the second bearing seat; Wherein, the impact device is arranged on the top of the animal head fixing plate, the front rotating shaft passes through the central through hole, and the other end of the rear rotating shaft is arranged in the bearing of the second bearing seat.

7. The craniocerebral injury device for animal translation, rotation and combination thereof as claimed in claim 6, characterized in that: The impact device comprises: A striking rod which vertically and detachably passes through the top of the animal head fixing plate; A fixing cap, which is in a disc structure and is vertically arranged at one end of the impact rod; The impact cap is vertically arranged on the other end of the impact rod.

8. The craniocerebral injury device for animal translation, rotation and combination thereof as claimed in claim 7, characterized in that: The animal head fixing plate is provided with a plurality of weight-reducing holes.

9. The craniocerebral injury device for animal translation, rotation and combination thereof as claimed in claim 8, characterized in that: The impact cap is made of elastic material.

10. The craniocerebral injury device for animal translation, rotation and combination thereof as claimed in claim 9, characterized in that: The material of the limiter is a brittle material or a tough material.

Images