Online filter with distribution plate and specific shrinkage shape

Abstract

The invention relates to the technical field of chromatographic filters, in particular to an online filter with a distribution plate and a specific shrinkage shape, the online filter comprises an upper cover plate and a lower cover plate, the top of the upper cover plate is fixedly connected with a liquid inlet pipe, the center of the bottom of the lower cover plate is fixedly connected with a liquid outlet pipe, and the lower cover plate is internally provided with a shrinkage cavity; a distribution plate is connected to the top of the inner wall of the contraction cavity, a sieve plate is connected to the position close to the top of the inner wall of the contraction cavity, and an O-shaped sealing ring is connected to the outer surface of the distribution plate. According to the online filter with the distribution plate and the specific shrinkage shape, the distribution plate is adopted to uniformly distribute a filtering solvent to the whole surface of the sieve plate, the filtering area is increased, the filtering effect is improved, meanwhile, accumulation of impurity particles on a single point of the sieve plate is reduced, and the service life of the sieve plate is effectively prolonged; by adopting a contraction section with a specific shape after filtration, the accumulation of samples in the filtering cavity is reduced, so that the flow velocity of the same flow section of the samples is consistent, the outlet pressure gradient of the joint is reduced, and the use safety is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of chromatographic filters, and specifically relates to an on-line filter with a distribution plate and a specific contraction shape. Background Art

[0002] The common on-line chromatographic filter consists of a sieve plate added in a cylindrical cavity. The solvent enters from the center of the upper cover plate of the cavity, first contacts the center of the sieve plate, and then passes through the sieve plate and converges and flows out at the center of the lower cover. As a result, after being used for a period of time, the impurity particles in the solvent accumulate at a single point in the center of the sieve plate, reducing the filtering effect of the sieve plate and increasing the system pressure. To solve the above problems, a distribution plate is added. The distribution plate is used to evenly distribute the filtered solvent to the entire surface of the sieve plate, increasing the filtering area and improving the filtering effect. At the same time, the accumulation of impurity particles at a single point on the sieve plate is reduced, effectively prolonging the service life of the sieve plate; a contraction section with a specific shape after filtration is adopted to reduce the accumulation of samples in the filter cavity, making the flow velocity of the sample consistent at the same flow section, and at the same time reducing the pressure gradient at the joint and increasing the use safety. Summary of the Invention

[0003] The purpose of the present invention is to provide an on-line filter with a distribution plate and a specific contraction shape to solve the problems raised in the above background art.

[0004] To achieve the above purpose, the present invention provides the following technical solution: An on-line filter with a distribution plate and a specific contraction shape, including an upper cover plate and a lower cover plate arranged at the bottom of the upper cover plate. A liquid inlet pipe is fixedly connected to the top of the upper cover plate, and a liquid outlet pipe is fixedly connected to the center of the bottom of the lower cover plate;

[0005] A contraction cavity is opened inside the lower cover plate. A distribution plate is connected to the top inner wall of the contraction cavity, and a sieve plate is connected to a position near the top of the inner wall of the contraction cavity.

[0006] Preferably, an O-ring is connected to the outer surface of the distribution plate, and the outer surface of the O-ring is connected to the inner wall of the contraction cavity.

[0007] Preferably, the bottom end of the liquid inlet pipe penetrates through the upper cover plate and is communicated with the inside of the contraction cavity, and the top end of the liquid outlet pipe penetrates through the lower cover plate and is communicated with the inside of the contraction cavity.

[0008] Preferably, flow channels and through holes are distributed on the upper surface of the distribution plate, and protrusions are arranged on the lower surface of the distribution plate.

[0009] Preferably, mounting holes are opened at the edge of the upper surface of the upper cover plate. Bolts are threadedly connected inside the mounting holes, and gaskets are connected between the bolts and the mounting holes.

[0010] Preferably, the mounting holes and bolts are symmetrically distributed at equal intervals on the upper surface of the upper cover plate, and the mounting holes penetrate through the upper cover plate and extend to the lower cover plate.

[0011] Preferably, the contraction cavity has a specific profile.

[0012] Preferably, the inner wall of the contraction cavity is provided with a convex clamping groove, and the outer surface of the sieve plate is clamped with the convex clamping groove.

[0013] Preferably, the mesh diameter of the sieve plate is 2 μm.

[0014] Preferably, the in-line filter is used for a system flow rate of 3 L / min and a maximum system pressure of 10 MPa.

[0015] Compared with the prior art, the beneficial effects of the present invention are:

[0016] The in-line filter with a distribution plate and a specific contraction shape evenly distributes the filtering solvent to the entire surface of the sieve plate by adding a distribution plate, increases the filtering area, improves the filtering effect, and at the same time reduces the accumulation of impurity particles at a single point on the sieve plate, effectively prolonging the service life of the sieve plate; adopts a specific-shaped contraction section after filtration to reduce the accumulation of samples in the filtration cavity, making the flow velocity of the samples consistent at the same flow section, and at the same time reducing the pressure gradient at the joint, increasing the use safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present invention, and those of ordinary skill in the art can also obtain other drawings based on these drawings without creative efforts.

[0018] Figure 1 It is a schematic diagram of the overall structure of the in-line filter of the present invention;

[0019] Figure 2 It is a schematic diagram of the internal structure of the in-line filter of the present invention;

[0020] Figure 3 It is a schematic diagram of the sieve plate structure of the present invention;

[0021] Figure 4 It is a schematic diagram of the contraction cavity structure of the present invention;

[0022] Figure 5 It is a sectional view of the in-line filter of the present invention;

[0023] Figure 6 It is a schematic diagram of the top structure of the distribution plate of the present invention;

[0024] Figure 7 Schematic diagram of the bottom structure of the distribution plate of the present invention;

[0025] Figure 8 CFD numerical analysis result diagram of the linear contraction cavity of the present invention;

[0026] Figure 9 CFD numerical analysis result diagram of the specific profile contraction cavity of the present invention;

[0027] Figure 10 Flow velocity distribution diagram of the linear contraction cavity and the specific profile contraction cavity of the present invention.

[0028] In the figure: 1. upper cover plate, 2. lower cover plate, 3. liquid inlet pipe, 4. liquid outlet pipe, 5. distribution plate, 6. sieve plate, 7. O-ring seal, 8. contraction cavity, 9. bolt, 10. gasket. Specific embodiments

[0029] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0030] In the present invention, unless otherwise clearly defined and limited, terms such as "installation", "connection", "connection", "fixation" and the like shall be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two elements or the interaction relationship between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0031] Please refer to Figures 1-10 , the present invention provides a technical solution:

[0032] An on-line filter with a distribution plate and a specific contraction shape, including an upper cover plate 1 and a lower cover plate 2 arranged at the bottom of the upper cover plate 1. The top of the upper cover plate 1 is fixedly connected with a liquid inlet pipe 3, and the center of the bottom of the lower cover plate 2 is fixedly connected with a liquid outlet pipe 4;

[0033] A contraction cavity 8 is opened inside the lower cover plate 2. The top of the inner wall of the contraction cavity 8 is connected with a distribution plate 5, and the position near the top of the inner wall of the contraction cavity 8 is connected with a sieve plate 6.

[0034] The outer surface of the distribution plate 5 is connected with an O-ring seal 7, and the outer surface of the O-ring seal 7 is connected with the inner wall of the contraction cavity 8. It plays a sealing role to prevent liquid leakage and ensure that the solvent can all pass through the distribution plate 5 and be evenly distributed onto the sieve plate 6.

[0035] The bottom end of the liquid inlet pipe 3 penetrates through the upper cover plate 1 and is communicated with the inside of the contraction cavity 8, and the top end of the liquid outlet pipe 4 penetrates through the lower cover plate 2 and is communicated with the inside of the contraction cavity 8, ensuring that the liquid can smoothly enter and exit the filter. The upper surface of the distribution plate 5 is provided with flow channels and through holes, and the lower surface of the distribution plate 5 is provided with protrusions. The design of the flow channels and through holes can evenly disperse the solvent, and the protrusions can increase the contact stability with the sieve plate 6, further ensuring that the solvent is evenly distributed over the entire surface of the sieve plate 6.

[0036] Installation holes are opened at the edge of the upper surface of the upper cover plate 1. Threaded bolts 9 are connected in the installation holes, and gaskets 10 are connected between the bolts 9 and the installation holes. The installation holes and the bolts 9 are symmetrically distributed at equal intervals on the upper surface of the upper cover plate 1. The installation holes penetrate through the upper cover plate 1 and extend to the lower cover plate 2. This structural design facilitates the installation and disassembly of the filter and at the same time ensures the stability of the connection between the upper cover plate 1 and the lower cover plate 2.

[0037] The contraction cavity 8 has a specific profile. The contraction cavity 8 with this specific profile can reduce the accumulation of samples in the filtration cavity and make the flow velocity of the samples consistent at the same flow cross-section. The inner wall of the contraction cavity 8 is provided with a protruding card slot, and the outer surface of the sieve plate 6 is snap-connected with the protruding card slot, facilitating the installation and fixation of the sieve plate 6. The mesh diameter of the sieve plate 6 is 2μm, and this pore size can effectively filter out most of the impurity particles, meeting the accuracy requirements of chromatographic filtration.

[0038] The in-line filter is used for a system flow rate of 3 L / min and a system maximum pressure of 10 MPa, specifying the applicable working conditions of the filter.

[0039] Analysis of the function of the distribution plate: When the filter is working, the solvent enters the flow channels on the upper surface of the distribution plate through the liquid inlet pipe of the upper cover plate. Assume that there are n flow channels on the distribution plate, and the cross-sectional area of each flow channel is A i (i = 1, 2, …, n), and the flow rate of the solvent is Q (Q = 3 L / min). According to the law of conservation of flow rate (Q i is the flow rate of each flow channel). Due to the reasonable design of the flow channels, it can be approximately considered that the flow rates of each flow channel are equal, that is The solvent is distributed to the through holes through the flow channels, and then flows to the lower surface of the distribution plate through the through holes and enters the sieve plate. In this way, the solvent can be evenly distributed over the entire surface of the sieve plate, increasing the filtration area. Assume that the area of the original impurity concentrated accumulation area on the sieve plate is S1. After using the distribution plate, the impurities are evenly distributed on the sieve plate area S, and the dispersion degree of the impurity accumulation is improved, effectively reducing the accumulation of impurity particles at a single point on the sieve plate. According to the filtration efficiency formula After uniform distribution, V 滤后 increases, and the filtration efficiency η is improved.

[0040] Analysis of the function of the contraction cavity: CFD (Computational Fluid Dynamics) numerical analysis is carried out on the straight contraction cavity and the cavity with a specific contraction profile. In the straight contraction cavity, let the flow velocity at the collection port be v1, and the flow velocity at the contraction wall be v 壁1 , and the flow velocity at the central position be v 中1 . According to the velocity distribution diagram, it can be seen that the velocity changes violently at the collection port, and the velocity gradient (Δ v is the velocity change amount, and Δx is the distance change amount) is large. Assuming that within the range of Δx from the collection port, the velocity changes from v 中1 to v1, and the velocity change amount is Δ v1 = v 中1 - v1, then the velocity gradient and the liquid flow velocity v 壁1 at the contraction wall is significantly less than the central position v 中1

[0041] In the cavity with a specific contraction profile, let the flow velocity at the collection port be v2, and the flow velocity at the contraction wall be v 壁2 , and the flow velocity at the central position be v 中2 . The velocity gradient Within the same distance change amount Δx′, the velocity change amount Δv′ = v 中2 - v2. Due to the design of the specific profile, Δv′ < Δv1, so G2 < G1. The outlet transition is uniform, and the wall flow velocity v 壁2 is basically the same as the central position v 中2 . According to Bernoulli's equation

[0042] (p is the pressure, ρ is the fluid density, and h is the height), when the height h remains unchanged, a small velocity change means a small pressure change. The flow is smoother behind the contraction outlet, the pressure is stable, the pressure gradient at the joint is reduced, and the use safety is increased. At the same time, since the accumulation of samples in the filtration cavity is reduced and the flow velocity is consistent at the same flow cross-section, it is more conducive to the system flow.

[0043] Effect comparison: As Figure 8 shown, CFD numerical analysis is carried out on the straight contraction cavity and the cavity with a specific contraction profile, and the results are as Figure 9As shown. According to the velocity distribution diagram, it can be seen that the straight-line contraction effect is significantly inferior to that of the specific profile contraction. In the straight-line contraction cavity, the velocity changes violently at the collection port, with a large gradient, and the liquid flow velocity on the contraction wall is significantly less than that at the central position. While in the velocity distribution field with a specific contraction profile, the velocity gradient is smaller, the outlet transition is more uniform, and the wall flow velocity is basically the same as that at the central position. Moreover, the flow is smoother behind the contraction outlet, which is beneficial to the system flow and pressure stability.

[0044] During use, the solvent enters the upper surface flow channel of the distribution plate 5 through the liquid inlet pipe 3 of the upper cover plate 1, is distributed to the through holes through the flow channel, and then flows to the lower surface of the distribution plate 5 through the through holes and enters the sieve plate 6. After passing through the sieve plate 6, the solvent is collected by the contraction cavity 8 with a specific profile and led out through the liquid outlet pipe 4.

[0045] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising a..." does not exclude the existence of additional identical elements in the process, method, article or device comprising the said element.

[0046] Although the embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An in-line filter having a distribution plate and a specific contraction shape, comprising an upper cover plate (1) and a lower cover plate (2) arranged at the bottom of the upper cover plate (1), characterized in that: The top of the upper cover plate (1) is fixedly connected with a liquid inlet pipe (3), and the bottom center of the lower cover plate (2) is fixedly connected with a liquid outlet pipe (4); A contraction cavity (8) is provided inside the lower cover plate (2), the top of the inner wall of the contraction cavity (8) is connected to a distribution plate (5), and a sieve plate (6) is connected to the inner wall of the contraction cavity (8) near the top.

2. An in-line filter with a distribution plate and a specific contraction shape according to claim 1, characterized in that: The outer surface of the distribution plate (5) is connected to an O-type sealing ring (7), and the outer surface of the O-type sealing ring (7) is connected to the inner wall of the contraction cavity (8).

3. An in-line filter with a distribution plate and a specific contraction shape according to claim 1, characterized in that: The bottom end of the liquid inlet pipe (3) passes through the upper cover plate (1) and is in communication with the interior of the contraction chamber (8), and the top end of the liquid outlet pipe (4) passes through the lower cover plate (2) and is in communication with the interior of the contraction chamber (8).

4. The in-line filter with a distribution plate and a specific contraction shape according to claim 1, characterized in that: The upper surface of the distribution plate (5) is provided with flow channels and through holes, and the lower surface of the distribution plate (5) is provided with protrusions.

5. The in-line filter with a distribution plate and a specific contraction shape according to claim 1, characterized in that: The upper surface edge of the upper cover plate (1) is provided with a mounting hole, a bolt (9) is threadedly connected to the mounting hole, and a gasket (10) is connected between the bolt (9) and the mounting hole.

6. An in-line filter with a distribution plate and a specific contraction shape according to claim 5, characterized in that: The mounting holes and bolts (9) are symmetrically distributed at equal intervals on the upper surface of the upper cover plate (1), and the mounting holes penetrate the upper cover plate (1) and extend to the lower cover plate (2).

7. An in-line filter with a distribution plate and a specific contraction shape according to claim 1, characterized in that: The contraction cavity (8) has a specific profile.

8. The in-line filter with a distribution plate and a specific contraction shape according to claim 1, characterized in that: The inner wall of the contraction cavity (8) is provided with a protruding groove, and the outer surface of the sieve plate (6) is engaged with the protruding groove.

9. The in-line filter with a distribution plate and a specific contraction shape according to claim 1, characterized in that: The mesh diameter of the sieve plate (6) is 2 μm.

10. The in-line filter with a distribution plate and a specific contraction shape according to claim 1, characterized in that: The online filter is used for a system flow of 3 L / min and a system maximum pressure of 10 MPa.

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