Chromosome specimen processing method and device and electronic equipment

Abstract

The embodiment of the invention discloses a chromosome specimen processing method and device and electronic equipment, and the method comprises the steps: responding to a first triggering operation, and synchronizing at least one split phase scanning image of a target chromosome specimen scanned by a first system to a second system based on target configuration information; for the at least one split phase scanning image, based on a pre-trained target cutting arrangement model, determining a chromosome karyotype graph corresponding to the split phase scanning image; the chromosome analysis result of the target object to which the chromosome specimen belongs is determined based on the chromosome karyotype graph corresponding to the at least one split phase scanning image, chromosome data transmission of the non-matched system can be automatically carried out according to the configuration information, the data transmission efficiency of the non-matched system is improved, the chromosome karyotype analysis time is shortened, and the analysis efficiency of the chromosome karyotype is improved. And the accuracy and the working efficiency of chromosome scanning analysis are improved.

Description

Technical Field

[0001] The embodiments of the present invention relate to the technical field of chromosome karyotype analysis, and in particular, to a method and device for processing chromosome specimens and an electronic device. Background Art

[0002] The fully automatic slide scanner used in chromosome karyotype analysis and the chromosome karyotype analysis system used for karyotype analysis are different systems. The fully automatic slide scanner is a hardware device for automatically collecting pictures, and the chromosome karyotype analysis system is a software system for karyotype analysis. Since the fully automatic slide scanner and the chromosome karyotype analysis system are non-matching systems, there are technical problems of asynchronous data transmission and low model recognition adaptation rate in actual use, resulting in long chromosome analysis time and low efficiency. Summary of the Invention

[0003] The present invention provides a method and device for processing chromosome specimens and an electronic device, so as to automatically conduct chromosome data transmission between non-matching systems according to configuration information, improve the data transmission efficiency of non-matching systems, shorten the chromosome karyotype analysis time, and improve the accuracy and working efficiency of chromosome scanning and analysis.

[0004] In a first aspect, an embodiment of the present invention provides a method for processing chromosome specimens, and the method includes:

[0005] In response to a first trigger operation, synchronize at least one metaphase scan image of a target chromosome specimen scanned in a first system to a second system based on target configuration information;

[0006] For the at least one metaphase scan image, determine a chromosome karyotype map corresponding to the metaphase scan image based on a pre-trained target cutting and arranging model; wherein, the target cutting and arranging model is trained by multiple groups of training sample sets, and the multiple groups of training sample sets at least include a first training sample set, a second training sample set, and a third training sample set; the first training sample set includes first chromosome karyotype maps corresponding to multiple first chromosome specimens in the same region, each first chromosome specimen corresponds to multiple first chromosome karyotype maps, and the multiple first chromosome karyotype maps include a preset number of correct chromosome karyotype maps; the second training sample set includes second chromosome karyotype maps corresponding to multiple second chromosome specimens in the same region, each second chromosome specimen corresponds to multiple second chromosome karyotype maps, and the multiple second chromosome karyotype maps are all correct chromosome karyotype maps; the third training sample set includes third chromosome karyotype maps corresponding to multiple third chromosome specimens in at least two different regions, each third chromosome specimen corresponds to multiple third chromosome karyotype maps, and the multiple third chromosome karyotype maps are all correct chromosome karyotype maps;

[0007] Based on the karyotype map corresponding to the at least one split-phase scan image, determine the chromosome analysis result of the target object to which the chromosome specimen belongs.

[0008] Further, the method further includes: Before responding to the first trigger operation, it further includes:

[0009] Respond to an editing operation on at least one preset configuration item, and determine at least one configuration item information corresponding to the target chromosome specimen; wherein, the at least one preset configuration item includes: a source file path configuration item corresponding to the first system, a target file path configuration item corresponding to the second system, an inspection item identification code configuration item, and a specimen identification code configuration item;

[0010] Based on the at least one configuration item information, determine the target configuration information corresponding to the target chromosome specimen.

[0011] Further, the method further includes: The target configuration information includes at least one of a source file path, a target file path, an inspection item identification code, and a specimen identification code. The synchronizing at least one split-phase scan image of the chromosome specimen scanned in the first system to the second system based on the target configuration information includes:

[0012] Perform a splicing process on the inspection item identification code and the specimen identification code to obtain a target folder name;

[0013] Based on the source file path, the target folder name, and the target file path, synchronize at least one split-phase scan image of the chromosome specimen scanned in the first system to the second system.

[0014] Further, the method further includes: The synchronizing at least one split-phase scan image of the chromosome specimen scanned in the first system to the second system based on the source file path, the target folder name, and the target file path includes:

[0015] Based on the source file path and the target folder name, find a first folder associated with the target folder name in the first system;

[0016] Perform a layer-by-layer parsing process on the first folder to obtain at least one split-phase scan image file that is consistent with the preset file suffix name;

[0017] Create a second folder in the target file path of the second system, and copy the at least one split-phase scan image file to the second folder of the second system.

[0018] Further, the method further includes: Training to obtain the target cutting and arranging model, including:

[0019] Train the first cutting and arranging model based on the first training sample set, and preliminarily adjust the model parameters of the first cutting and arranging model to obtain a second cutting and arranging model;

[0020] Train the second cutting and arranging model based on the second training sample set, and perform a second adjustment on the model parameters of the second cutting and arranging model to obtain a third cutting and arranging model;

[0021] Train the third cutting and arranging model based on the third training sample set, and perform a third adjustment on the model parameters of the third cutting and arranging model to obtain a target cutting and arranging model.

[0022] Further, the method further includes: scanning and processing the identification code at a preset position of the target chromosome specimen by an identification code scanning device on the first system to obtain specimen collection information corresponding to the target chromosome specimen; wherein, the specimen collection information at least includes a specimen collection location and a specimen collection time;

[0023] Based on the specimen collection information, determine a target scanning parameter template from at least one pre-configured scanning parameter template; wherein, the scanning parameter template includes preset parameter values corresponding to at least one scanning parameter item, and the target scanning parameter template includes a target low-power lens parameter template and a target high-power lens parameter template;

[0024] Based on the low-power lens scanning device on the first system and the target low-power lens parameter template, perform a preliminary scan on the target chromosome specimen to obtain a plurality of first specimen scan images;

[0025] Based on a preset image classifier, perform screening processing on the plurality of first specimen scan images to obtain at least one second specimen scan image;

[0026] Based on the high-power lens scanning device on the first system, the target scanning position corresponding to the second specimen scan image, and the target high-power lens parameter template, perform a secondary scan on the target chromosome specimen to obtain a plurality of third specimen scan images;

[0027] Determine at least one mitotic phase scan image of the target chromosome specimen based on the plurality of third specimen scan images.

[0028] Further, the specimen collection information further includes: a specimen identification code and a test item identification code, and the method further includes:

[0029] Based on the specimen identification code and / or the test item identification code of the target chromosome specimen, create a target folder on the first system to store the at least one scanned metaphase image in the target folder.

[0030] Further, the method further includes: generating and presenting a target report corresponding to the target object based on the at least one scanned metaphase image, the corresponding chromosome karyotype map, and the chromosome analysis result.

[0031] In a second aspect, an embodiment of the present invention further provides a chromosome specimen processing device, which includes:

[0032] A data synchronization module, configured to, in response to a first trigger operation, synchronize at least one scanned metaphase image of a target chromosome specimen scanned on a first system to a second system based on target configuration information;

[0033] A karyotype map determination module, configured to determine a chromosome karyotype map corresponding to a scanned metaphase image based on a pre-trained target cutting and arranging model for at least one scanned metaphase image; wherein, the target cutting and arranging model is obtained by training with multiple groups of training sample sets, and the multiple groups of training sample sets at least include a first training sample set, a second training sample set, and a third training sample set; the first training sample set includes first chromosome karyotype maps corresponding to multiple first chromosome specimens in the same region, each first chromosome specimen corresponding to multiple first chromosome karyotype maps, and the multiple first chromosome karyotype maps including a preset number of correct chromosome karyotype maps; the second training sample set includes second chromosome karyotype maps corresponding to multiple second chromosome specimens in the same region, each second chromosome specimen corresponding to multiple second chromosome karyotype maps, and all the multiple second chromosome karyotype maps being correct chromosome karyotype maps; the third training sample set includes third chromosome karyotype maps corresponding to multiple third chromosome specimens in at least two different regions, each third chromosome specimen corresponding to multiple third chromosome karyotype maps, and all the multiple third chromosome karyotype maps being correct chromosome karyotype maps;

[0034] An analysis result determination module, configured to determine a chromosome analysis result of a target object to which the chromosome specimen belongs based on the chromosome karyotype map corresponding to the at least one scanned metaphase image.

[0035] In a third aspect, an embodiment of the present invention further provides an electronic device, which includes:

[0036] One or more processors;

[0037] A storage device, configured to store one or more programs,

[0038] When one or more programs are executed by one or more processors, the one or more processors implement the chromosome specimen processing method according to any of the embodiments of the present invention.

[0039] In a fourth aspect, an embodiment of the present invention further provides a storage medium containing computer-executable instructions, and the computer-executable instructions are used to execute the chromosome specimen processing method according to any of the embodiments of the present invention when executed by a computer processor.

[0040] The technical solution of the embodiment of the present invention synchronizes at least one metaphase scan image of a target chromosome specimen scanned in a first system to a second system based on target configuration information in response to a first trigger operation. Furthermore, for at least one metaphase scan image, a chromosome karyotype map corresponding to the metaphase scan image is determined based on a pre-trained target cutting and arranging model. Thus, based on the chromosome karyotype maps corresponding to at least one metaphase scan image, a chromosome analysis result of a target object to which the chromosome specimen belongs is determined. The technical solution of this embodiment can automatically conduct chromosome data transmission between non-matching systems according to configuration information, improve the data transmission efficiency of non-matching systems, shorten the chromosome karyotype analysis time, and enhance the accuracy and working efficiency of chromosome scan analysis. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] In order to more clearly illustrate the technical solutions of the exemplary embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the introduced drawings are only the drawings of a part of the embodiments to be described by the present invention, rather than all the drawings. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings without creative efforts.

[0042] Figure 1 It is a schematic flowchart of a chromosome specimen processing method provided by an embodiment of the present invention;

[0043] Figure 2 It is an example diagram of a metaphase scan image involved in an embodiment of the present invention;

[0044] Figure 3 It is a schematic diagram of the target configuration information edited in a target page involved in an embodiment of the present invention;

[0045] Figure 4 It is an example diagram of a chromosome karyotype map involved in an embodiment of the present invention;

[0046] Figure 5 It is a schematic flowchart of another chromosome specimen processing method provided by an embodiment of the present invention;

[0047] Figure 6Schematic structural diagram of a chromosome specimen processing device provided by an embodiment of the present invention;

[0048] Figure 7 Schematic structural diagram of an electronic device provided by an embodiment of the present invention. Specific embodiments

[0049] The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It can be understood that the specific embodiments described herein are only used to explain the present invention, rather than limiting the present invention. In addition, it should be noted that for the convenience of description, only parts related to the present invention rather than all structures are shown in the drawings.

[0050] Embodiment 1

[0051] Figure 1 Schematic flowchart of a chromosome specimen processing method provided by an embodiment of the present invention. This embodiment is applicable to any situation requiring chromosome karyotype analysis. This method can be executed by a chromosome specimen processing device, which can be implemented in the form of software and / or hardware. The hardware can be an electronic device, such as a mobile terminal, a PC terminal, or a server, etc.

[0052] As Figure 1 shown, the chromosome specimen processing method includes:

[0053] S110. In response to a first trigger operation, synchronize at least one metaphase scan image of a target chromosome specimen scanned in a first system to a second system based on target configuration information.

[0054] Among them, the target chromosome specimen is the chromosome specimen to be processed and analyzed. The chromosome specimen is prepared through a series of processing steps, including cell fixation, chromosome extraction, staining, and slide production, etc. The prepared chromosome specimen can clearly observe the morphology, quantity, and structural characteristics of chromosomes under a microscope, which is of great significance for chromosome karyotype analysis. For example, in prenatal diagnosis, amniotic fluid cells can be processed into chromosome specimens for rapid prenatal diagnosis to detect whether the fetus has chromosomal abnormalities. The metaphase scan image refers to the image obtained by scanning the chromosomes of metaphase cells through a full-automatic chromosome scanning system (i.e., the first system). The first system can automatically search for the chromosomes of metaphase cells and automatically capture the images of these cells. These captured images are the metaphase scan images, which show the specific morphology of chromosomes during cell division. For example, for an example diagram of a metaphase scan image, see Figure 2 .

[0055] Among them, the first triggering operation is an operation to synchronize chromosome scanning images. The target configuration information is the information content edited by the user on the target page, and the target configuration information is the information content based on which the second system obtains the metaphase scanning images from the first system. The first system is a hardware device that supports scanning chromosome specimens to obtain metaphase scanning images. The second system is a server for hosting a chromosome karyotyping analysis system. The chromosome karyotyping analysis system refers to a software system that can perform karyotyping analysis on metaphase scanning images.

[0056] In this embodiment, the first system can be used to scan the target chromosome specimen to obtain one or more metaphase scanning images corresponding to the target chromosome specimen, and then these metaphase scanning images can be stored in the specified storage space of the first system. A plug-in tool for data synchronization of metaphase scanning images can be developed in advance, and the plug-in tool is pre-configured with a target page for editing the target configuration information. In a specific application, the first system and the second system can be set to a shared communication state in the internal network, and the plug-in tool can be installed in the second system. When the user needs to analyze the chromosome data of a certain patient based on the chromosome arrangement and segmentation model integrated in the second system, the user can trigger the icon corresponding to the plug-in tool in the second system. At this time, the target page (the target page is an editing page for hosting at least one configuration item information) can be displayed on the current display interface. The user can edit the target configuration information on the target page. After completing the editing, the user can trigger a preset picture synchronization control (i.e., the first triggering operation). At this time, the second system can grab one or more metaphase scanning images corresponding to the target chromosome specimen from the specified storage space of the first system according to the target configuration information, and store these images in the preset storage space of the second system.

[0057] Optionally, the specific implementation manner of determining the target configuration information may include: in response to an editing operation on at least one preset configuration item, determining at least one configuration item information corresponding to the target chromosome specimen; and based on the at least one configuration item information, determining the target configuration information corresponding to the target chromosome specimen.

[0058] Among them, at least one preset configuration item includes: a source file path configuration item corresponding to the first system, a target file path configuration item corresponding to the second system, an inspection item identification code configuration item, and a specimen identification code configuration item. Specifically, the source file path configuration item is a configuration item characterizing the storage location of the metaphase scan image in the first system; the target file path configuration item is a configuration item characterizing the storage location where the metaphase scan image will be stored in the second system; the inspection item identification code configuration item is a configuration item representing the inspection item corresponding to the target chromosome specimen; the specimen identification code configuration item is a configuration item representing the identification code information corresponding to the target chromosome specimen. The configuration item information refers to the information content edited by the user in various configuration item edit boxes.

[0059] In this embodiment, an edit box corresponding to at least one preset configuration item can be displayed on the target page, and the user can input or select the configuration item information corresponding to the target chromosome specimen in each edit box, so that these configuration item information can be determined as the target configuration information corresponding to the target chromosome specimen.

[0060] Specifically, the target configuration information includes at least one of a source file path, a target file path, an inspection item identification code, and a specimen identification code. Exemplarily, for a schematic diagram of the target configuration information edited on the target page, see Figure 3 , as Figure 3 shown, the first edit box is the edit box corresponding to the source file path configuration item, and the corresponding configuration item information is "D: / Desktop / source"; the second edit box is the edit box corresponding to the target file path configuration item, and the corresponding configuration item information is "D: / Desktop / back"; the third edit box is the edit box corresponding to the inspection item identification code configuration item, and the corresponding configuration item information is "Y"; the fourth and fifth edit boxes are the edit boxes corresponding to the specimen identification code configuration item. If only the metaphase scan image corresponding to a certain chromosome specimen is to be obtained, the identification code information corresponding to the chromosome label can be input in the fourth edit box; if the metaphase scan images corresponding to multiple chromosome specimens are to be obtained in batches, the identification code information corresponding to the starting chromosome label can be input in the fourth edit box, and the identification code information corresponding to the ending chromosome label can be input in the fifth edit box, so that the metaphase scan images corresponding to multiple chromosome specimens can be obtained in batches.

[0061] In the specific application process, the specific implementation method of synchronizing at least one metaphase scan image of the target chromosome specimen scanned in the first system to the second system based on the target configuration information may include:

[0062] S1. Perform splicing processing on the inspection item identification code and the specimen identification code to obtain the target folder name.

[0063] In this embodiment, since the corresponding data content of a certain chromosome specimen in the first system is saved in a folder whose file name is related to the test item identification code and the specimen identification code, based on this, the test item identification code and the specimen identification code on the editing page can be spliced to obtain a string containing the test item identification code and the specimen identification code, and this string is the target folder name.

[0064] S2. Synchronize at least one metaphase scan image of the chromosome specimen scanned in the first system to the second system based on the source file path, the target folder name, and the target file path.

[0065] In this embodiment, according to the source file path and the target folder name, the metaphase scan images corresponding to the target chromosome specimen can be found in the first system. Thus, these metaphase scan images can be synchronously copied to the specified folder under the target file path of the second system, thereby realizing the operation of synchronizing at least one metaphase scan image of the target chromosome specimen scanned in the first system to the second system.

[0066] Optionally, the specific implementation of synchronizing at least one metaphase scan image of the target chromosome specimen scanned in the first system to the second system based on the source file path, the target folder name, and the target file path may include: finding a first folder associated with the target folder name from the first system based on the source file path and the target folder name; performing a layer-by-layer parsing process on the first folder to obtain at least one metaphase scan image file that is consistent with the preset file suffix name; creating a second folder in the target file path of the second system, and copying the at least one metaphase scan image file to the second folder of the second system.

[0067] In this embodiment, according to the source file path and the target folder name, a first folder associated with the target folder name can be found in the storage space of the first system. Since the first folder may be a multi-layer nested folder, therefore, a layer-by-layer parsing process can be performed on the first folder to check whether the file content with the preset file suffix name is included in the files at each level of the first folder. If it is included, these file contents are determined as the metaphase scan images corresponding to the target chromosome specimen. At the same time, a blank second folder can be created in the target file path of the second system, and the found metaphase scan images are copied to this second folder. Thus, one or more metaphase scan images of the target chromosome specimen scanned in the first system are synchronized to the second system.

[0068] S120. For at least one metaphase scan image, determine the chromosome karyotype map corresponding to the metaphase scan image based on the pre-trained target cutting and arranging model.

[0069] Among them, the target cutting and arranging model is used to perform cutting and arranging processing on the split-phase scanned image to obtain the corresponding chromosome karyotype map. A chromosome karyotype map refers to a standardized image formed by arranging the chromosomes in an individual cell according to size, shape, and centromere position. For example, see the example diagram of the chromosome karyotype map in Figure 4 . It can be understood that the target cutting and arranging model has been pre-configured in the second system.

[0070] In this embodiment, the target cutting and arranging model is obtained by training with multiple groups of training sample sets. The multiple groups of training sample sets at least include a first training sample set, a second training sample set, and a third training sample set.

[0071] The first training sample set includes the first chromosome karyotype maps corresponding to multiple first chromosome specimens in the same region. Each first chromosome specimen corresponds to multiple first chromosome karyotype maps, and the multiple first chromosome karyotype maps include a preset number of correct chromosome karyotype maps. Among them, the correct chromosome karyotype map refers to the chromosome karyotype map obtained by manually arranging and dividing the split-phase scanned image. For example, the first training sample set includes the first chromosome karyotype maps of 100,000 first chromosome specimens, and these 100,000 first chromosome specimens are all samples from the same region. Each first chromosome specimen includes 30 first chromosome karyotype maps, and among these 30 first chromosome karyotype maps, there are 25 correct chromosome karyotype maps and 5 incorrect chromosome karyotype maps (it can be understood that the incorrect chromosome karyotype maps here refer to the chromosome karyotype maps obtained by non-manual arranging and dividing processing, which can be the chromosome karyotype maps determined by other splitting and arranging tools. Since the correctness of these chromosome karyotype maps cannot be determined, they are called incorrect chromosome karyotype maps).

[0072] The second training sample set includes the second chromosome karyotype maps corresponding to multiple second chromosome specimens in the same region. Each second chromosome specimen corresponds to multiple second chromosome karyotype maps, and all the multiple second chromosome karyotype maps are correct chromosome karyotype maps. For example, the second training sample set includes the second chromosome karyotype maps of 80,000 second chromosome specimens, and these 80,000 second chromosome specimens are all samples from the same region. Each second chromosome specimen includes 30 second chromosome karyotype maps, and all these 30 second chromosome karyotype maps are correct chromosome karyotype maps.

[0073] The third training sample set includes third chromosome karyotype maps corresponding to multiple third chromosome specimens from at least two different regions. Each third chromosome specimen corresponds to multiple third chromosome karyotype maps, and all of the multiple third chromosome karyotype maps are correct chromosome karyotype maps. For example, the third training sample set includes third chromosome karyotype maps of 80,000 third chromosome specimens. Among these 80,000 third chromosome specimens, 20,000 third chromosome specimens are from region A, 30,000 third chromosome specimens are from region B, and 30,000 third chromosome specimens are from region C. Each third chromosome specimen includes 30 third chromosome karyotype maps, and all of these 30 third chromosome karyotype maps are correct chromosome karyotype maps.

[0074] In the specific application process, the to-be-trained cutting and arranging model with default initial model parameters can be trained for multiple rounds through the first training sample set, the second training sample set, and the third training sample set to obtain the target cutting and arranging model. Optionally, the specific implementation manner of training to obtain the target cutting and arranging model may include: training the first cutting and arranging model based on the first training sample set, and preliminarily adjusting the model parameters of the first cutting and arranging model to obtain the second cutting and arranging model; training the second cutting and arranging model based on the second training sample set, and performing a second adjustment on the model parameters of the second cutting and arranging model to obtain the third cutting and arranging model; training the third cutting and arranging model based on the third training sample set, and performing a third adjustment on the model parameters of the third cutting and arranging model to obtain the target cutting and arranging model.

[0075] In this embodiment, the first cutting and arranging model with initial model parameters can be trained through the first training sample set. After preliminarily adjusting the model parameters of the first cutting and arranging model, the second cutting and arranging model is obtained. Further, the second cutting and arranging model is trained for a second round through the second training sample set. After performing a second adjustment on the model parameters of the second cutting and arranging model, the third cutting and arranging model is obtained. Furthermore, the third cutting and arranging model is trained for a third round through the third training sample set. After performing a third adjustment on the model parameters of the third cutting and arranging model, the target cutting and arranging model is obtained. In this embodiment, the cutting and arranging model is trained multiple times through different training sample sets, which improves the performance of the cutting and arranging model. In addition, since the third training sample set takes into account the influence of chromosome specimens from multiple different regions on the model's cutting and arranging, the generalization ability of the cutting and arranging model is improved, and further the performance of the cutting and arranging model is improved.

[0076] In the specific application process, the processing of each split-phase scanned image is the same. Here, any one of the split-phase scanned images is taken as the current split-phase scanned image, and an exemplary description is given taking the current split-phase scanned image as an example. The current split-phase scanned image can be input into a pre-trained target cutting and arranging model, and the target cutting and arranging model can output a chromosome karyotype map corresponding to the current split-phase scanned image.

[0077] S130. Determine the chromosome analysis result of the target object to which the chromosome specimen belongs based on the chromosome karyotype map corresponding to at least one split-phase scanned image.

[0078] Among them, the target object refers to the object to which the chromosome specimen belongs. For example, the target object can be a certain patient. The chromosome analysis result is used to characterize whether there is an abnormality in the chromosomes of the target object and which specific chromosome is abnormal.

[0079] In this embodiment, a karyotype map analysis model can be pre-configured in the second system. By inputting the chromosome karyotype maps corresponding to each split-phase scanned image into the karyotype map analysis model, the chromosome analysis result of the target object to which the chromosome specimen belongs can be obtained. In addition, the chromosome karyotype maps corresponding to at least one split-phase scanned image can be displayed on the display page of the second system. Professional technicians can combine their own experience and use the preset shortcut keys to flip through and observe and analyze these chromosome karyotype maps to obtain the chromosome analysis result of the target object to which the chromosome specimen belongs.

[0080] Based on the above embodiment, a target report corresponding to the target object can also be generated and displayed based on at least one split-phase scanned image, the corresponding chromosome karyotype map, and the chromosome analysis result.

[0081] Among them, the target report refers to a report file that summarizes various processing results obtained by the chromosome specimen processing method provided in this embodiment.

[0082] In this embodiment, a report file can be summarized and generated according to a preset report summary template for the at least one split-phase scanned image, the corresponding chromosome karyotype map, and the chromosome analysis result determined in the above steps. This report file is the target report. The target report can be displayed on any device with a display function.

[0083] It should be noted that in the technical solution of this application, the acquisition, storage, use, processing, etc. of data all comply with the relevant regulations of national laws and regulations. For example, intercept and process network requests with the authorization of the user.

[0084] In the technical solution of the embodiment of the present invention, in response to a first trigger operation, at least one metaphase scan image of a target chromosome specimen scanned in a first system is synchronized to a second system based on target configuration information. Furthermore, for at least one metaphase scan image, based on a pre-trained target cutting and arranging model, a chromosome karyotype map corresponding to the metaphase scan image is determined. Thus, based on the chromosome karyotype maps corresponding to at least one metaphase scan image, a chromosome analysis result of a target object to which the chromosome specimen belongs is determined. The technical solution of this embodiment can automatically conduct chromosome data transmission between non-matching systems according to the configuration information, improve the data transmission efficiency of non-matching systems, shorten the chromosome karyotype analysis time, and enhance the accuracy and working efficiency of chromosome scanning and analysis.

[0085] Embodiment 2

[0086] Figure 5 It is a schematic diagram of a method for processing a chromosome specimen provided by an embodiment of the present invention. On the basis of the foregoing embodiment, the data scanning method of the first system is described in detail, and its specific implementation manner can refer to the technical solution of this embodiment. Among them, the same or corresponding technical terms as those in the above embodiment will not be elaborated herein.

[0087] As Figure 5 shown, the method specifically includes the following steps:

[0088] S210. Scan and process the identification code at a preset position of the target chromosome specimen by using an identification code scanning device on the first system to obtain specimen collection information corresponding to the target chromosome specimen.

[0089] Among them, the identification code scanning device refers to a hardware structure for scanning the identification code on a chromosome specimen slide. The specimen collection information is used to characterize the collection attributes of the target chromosome specimen, and at least includes the specimen collection location and the specimen collection time.

[0090] In this embodiment, the target chromosome specimen corresponds to a unique identification code, and the paper identification code can be pasted at a preset position of the target chromosome specimen. The identification code corresponding to the target chromosome specimen has been associated with the specimen collection information corresponding to the target chromosome specimen. Based on this, when the identification code scanning device on the first system scans and processes the identification code at a preset position of the target chromosome specimen, the specimen collection information corresponding to the target chromosome specimen can be automatically obtained.

[0091] S220. Determine a target scan parameter template from at least one pre-configured scan parameter template based on the specimen collection information.

[0092] Among them, the scanning parameter template includes preset parameter values corresponding to at least one scanning parameter item. The target scanning parameter template includes a target low-power lens parameter template and a target high-power lens parameter template. The target low-power lens parameter template is the scanning parameter that the first system can adopt in the low-power lens mode, and the target high-power lens parameter template is the scanning parameter that the first system can adopt in the high-power lens mode. At least one scanning parameter item may include: brightness parameter item, contrast parameter item, sharpness parameter item, and so on.

[0093] In this embodiment, the first system can scan a clear scanning image of the mitotic phase, which is a prerequisite for obtaining a correct chromosome analysis result. Based on this, when the first system performs a scanning process on a chromosome specimen, it can improve the clarity of the mitotic phase scanning image by adjusting the scanning parameters, thereby improving the accuracy of the chromosome analysis result. Since the climatic conditions corresponding to different regions and different seasons are different, and the climatic conditions have a greater impact on the preparation quality of chromosome specimens, multiple different scanning parameter templates can be pre-configured for different regions and different seasons, and the chromosome specimens can be scanned through the scanning parameter items set in the scanning parameter template to minimize the specimen quality differences caused by climate changes. Specifically, multiple scanning parameter templates can be pre-configured, and the regions and seasons adapted to each scanning parameter template are defined. Thus, after obtaining the specimen collection information of the target chromosome specimen, the target scanning parameter template adapted to it can be determined from multiple scanning parameter templates according to the specimen collection location and specimen collection time in the specimen collection information.

[0094] S230. Based on the low-power lens scanning device on the first system and the target low-power lens parameter template, perform a preliminary scan on the target chromosome specimen to obtain a plurality of first specimen scanning images.

[0095] In this embodiment, the scanning parameters of the low-power lens scanning device of the first system can be set to the target low-power lens parameter template, and a plurality of first specimen scanning images can be obtained by performing a preliminary scan on the target chromosome specimen through the low-power lens scanning device.

[0096] S240. Based on the preset image classifier, perform a screening process on the plurality of first specimen scanning images to obtain at least one second specimen scanning image.

[0097] Among them, the preset image classifier is used to perform a screening process on a large number of first specimen scanning images to screen out scanning images with relatively good clarity.

[0098] In this embodiment, the plurality of first specimen scanning images determined in the previous step can be input into the preset image classifier, and an image quality score corresponding to each first specimen scanning image can be obtained. Thus, a certain number of second specimen scanning images can be determined from these first specimen scanning images according to each quality score.

[0099] S250. Based on the high-magnification lens scanning device on the first system and the target high-magnification lens parameter template corresponding to the second specimen scanning image, perform a secondary scan on the target chromosome specimen to obtain multiple third specimen scanning images.

[0100] In this embodiment, the scanning parameters of the high-magnification lens scanning device of the first system can be set to the target high-magnification lens parameter template, and the target scanning position in the target chromosome specimen is scanned a second time through the high-magnification lens scanning device to obtain multiple third specimen scanning images.

[0101] S260. Determine at least one metaphase scanning image of the target chromosome specimen based on the multiple third specimen scanning images.

[0102] In this embodiment, the multiple third specimen scanning images scanned by the high-magnification lens scanning device can be determined as at least one metaphase scanning image of the target chromosome specimen.

[0103] Based on the above embodiments, optionally, the specimen collection information further includes: a specimen identification code and an inspection item identification code, and the method further includes: creating a target folder on the first system based on the specimen identification code and / or inspection item identification code of the target chromosome specimen to store at least one metaphase scanning image in the target folder.

[0104] In this embodiment, a target folder can be created on the first system, and the target folder is named according to the specimen identification code and / or inspection item identification code, and then at least one metaphase scanning image is stored in the target folder.

[0105] S270. In response to the first trigger operation, synchronize at least one metaphase scanning image of the target chromosome specimen scanned on the first system to the second system based on the target configuration information.

[0106] S280. For at least one metaphase scanning image, determine a chromosome karyotype map corresponding to the metaphase scanning image based on the pre-trained target cutting and arranging model.

[0107] Among them, the target cutting and arranging model is obtained by training with multiple groups of training sample sets. The multiple groups of training sample sets at least include a first training sample set, a second training sample set, and a third training sample set. The first training sample set includes first chromosome karyotype maps corresponding to multiple first chromosome specimens in the same region. Each first chromosome specimen corresponds to multiple first chromosome karyotype maps, and the multiple first chromosome karyotype maps include a preset number of correct chromosome karyotype maps. The second training sample set includes second chromosome karyotype maps corresponding to multiple second chromosome specimens in the same region. Each second chromosome specimen corresponds to multiple second chromosome karyotype maps, and all the multiple second chromosome karyotype maps are correct chromosome karyotype maps. The third training sample set includes third chromosome karyotype maps corresponding to multiple third chromosome specimens in at least two different regions. Each third chromosome specimen corresponds to multiple third chromosome karyotype maps, and all the multiple third chromosome karyotype maps are correct chromosome karyotype maps.

[0108] S290. Determine the chromosome analysis result of the target object to which the chromosome specimen belongs based on the chromosome karyotype map corresponding to at least one metaphase scanning image.

[0109] In the technical solution of the embodiment of the present invention, when the first system scans the target chromosome specimen, the identification code scanning device on the first system can scan the identification code at a preset position of the target chromosome specimen to obtain the specimen collection information corresponding to the target chromosome specimen. Then, based on the specimen collection information, the target scanning parameter template is determined from at least one pre-configured scanning parameter template. Based on the low-power microscope scanning device on the first system and the target low-power microscope parameter template, the target chromosome specimen is preliminarily scanned to obtain multiple first specimen scanning images. Further, based on a preset image classifier, the multiple first specimen scanning images are screened to obtain at least one second specimen scanning image. Based on the high-power microscope scanning device on the first system, the target scanning position corresponding to the second specimen scanning image, and the target high-power microscope parameter template, the target chromosome specimen is scanned a second time to obtain multiple third specimen scanning images. Based on the multiple third specimen scanning images, at least one metaphase scanning image of the target chromosome specimen is determined. By this scanning method, the clarity of the metaphase scanning image is improved, and thus the accuracy of the chromosome analysis result is enhanced.

[0110] Embodiment III

[0111] Figure 6 FIG. 13 is a schematic structural diagram of a chromosome specimen processing device provided by an embodiment of the present invention. The device includes: a data synchronization module 310, a karyotype map determination module 320, and an analysis result determination module 330.

[0112] Among them, the data synchronization module 310 is configured to, in response to a first trigger operation, synchronize at least one metaphase scan image of a target chromosome specimen scanned in a first system to a second system based on target configuration information;

[0113] The karyotype map determination module 320 is configured to determine a chromosome karyotype map corresponding to a metaphase scan image based on a pre-trained target cutting and arranging model for at least one metaphase scan image; wherein, the target cutting and arranging model is obtained by training with multiple groups of training sample sets, and the multiple groups of training sample sets at least include a first training sample set, a second training sample set, and a third training sample set; the first training sample set includes first chromosome karyotype maps corresponding to multiple first chromosome specimens in the same region, each first chromosome specimen corresponding to multiple first chromosome karyotype maps, and the multiple first chromosome karyotype maps include a preset number of correct chromosome karyotype maps; the second training sample set includes second chromosome karyotype maps corresponding to multiple second chromosome specimens in the same region, each second chromosome specimen corresponding to multiple second chromosome karyotype maps, and the multiple second chromosome karyotype maps are all correct chromosome karyotype maps; the third training sample set includes third chromosome karyotype maps corresponding to multiple third chromosome specimens in at least two different regions, each third chromosome specimen corresponding to multiple third chromosome karyotype maps, and the multiple third chromosome karyotype maps are all correct chromosome karyotype maps;

[0114] The analysis result determination module 330 is configured to determine a chromosome analysis result of a target object to which a chromosome specimen belongs based on a chromosome karyotype map corresponding to at least one metaphase scan image.

[0115] Based on the above device, optionally, the chromosome specimen processing device further includes: an information configuration module, configured to, in response to an editing operation for at least one preset configuration item, determine at least one configuration item information corresponding to a target chromosome specimen; wherein, the at least one preset configuration item includes: a source file path configuration item corresponding to the first system, a target file path configuration item corresponding to the second system, a test item identification code configuration item, and a specimen identification code configuration item; based on the at least one configuration item information, determine target configuration information corresponding to the target chromosome specimen.

[0116] Based on the above device, optionally, the target configuration information includes at least one of a source file path, a target file path, a test item identification code, and a specimen identification code, and the data synchronization module 310 includes:

[0117] A folder name determination unit, configured to perform splicing processing on the test item identification code and the specimen identification code to obtain a target folder name;

[0118] A data synchronization unit, configured to synchronize at least one mitotic phase scan image of a chromosome specimen scanned in a first system to a second system based on the source file path, the target folder name, and the target file path.

[0119] Based on the above device, optionally, the data synchronization unit is specifically configured to find a first folder associated with the target folder name from the first system based on the source file path and the target folder name; perform a layer-by-layer parsing process on the first folder to obtain at least one mitotic phase scan image file that is consistent with a preset file suffix name; create a second folder in the target file path of the second system, and copy the at least one mitotic phase scan image file to the second folder of the second system.

[0120] Based on the above device, optionally, the chromosome specimen processing device further includes: a model training module, configured to train a first cutting and arranging model based on the first training sample set, perform a preliminary adjustment on the model parameters of the first cutting and arranging model to obtain a second cutting and arranging model; train the second cutting and arranging model based on the second training sample set, perform a second adjustment on the model parameters of the second cutting and arranging model to obtain a third cutting and arranging model; train the third cutting and arranging model based on the third training sample set, perform a third adjustment on the model parameters of the third cutting and arranging model to obtain a target cutting and arranging model.

[0121] Based on the above device, optionally, the chromosome specimen processing device further includes: a mitotic phase scanning module; the mitotic phase scanning module includes:

[0122] A specimen information determination unit, configured to scan a specimen identification code at a preset position of the target chromosome specimen through an identification code scanning device on the first system to obtain specimen collection information corresponding to the target chromosome specimen; wherein, the specimen collection information at least includes a specimen collection location and a specimen collection time;

[0123] A scanning template determination unit, configured to determine a target scanning parameter template from at least one pre-configured scanning parameter template based on the specimen collection information; wherein, the scanning parameter template includes preset parameter values corresponding to at least one scanning parameter item, and the target scanning parameter template includes a target low-power lens parameter template and a target high-power lens parameter template;

[0124] A low-power lens scanning unit, configured to perform a preliminary scan on the target chromosome specimen based on a low-power lens scanning device on the first system and the target low-power lens parameter template to obtain a plurality of first specimen scan images;

[0125] A scanning image screening unit, configured to screen the multiple first specimen scanning images based on a preset image classifier to obtain at least one second specimen scanning image;

[0126] A secondary scanning unit, configured to perform secondary scanning on the target chromosome specimen based on the high-power lens scanning device on the first system, the target scanning position corresponding to the second specimen scanning image, and the target high-power lens parameter template to obtain multiple third specimen scanning images;

[0127] A mitotic phase image determination unit, configured to determine at least one mitotic phase scanning image of the target chromosome specimen based on the multiple third specimen scanning images.

[0128] Based on the above device, optionally, the specimen collection information further includes: a specimen identification code and a test item identification code. The mitotic phase scanning module is further configured to create a target folder on the first system based on the specimen identification code and / or the test item identification code of the target chromosome specimen to store the at least one mitotic phase scanning image in the target folder.

[0129] Based on the above device, optionally, the chromosome specimen processing device further includes: a report generation module, configured to generate and display a target report corresponding to the target object based on the at least one mitotic phase scanning image, the corresponding chromosome karyotype map, and the chromosome analysis result.

[0130] The technical solution of the embodiment of the present invention synchronizes at least one mitotic phase scanning image of the target chromosome specimen scanned on the first system to the second system based on the target configuration information in response to a first trigger operation. Furthermore, for the at least one mitotic phase scanning image, a chromosome karyotype map corresponding to the mitotic phase scanning image is determined based on a pre-trained target cutting and arrangement model. Thus, based on the chromosome karyotype map corresponding to the at least one mitotic phase scanning image, the chromosome analysis result of the target object to which the chromosome specimen belongs is determined. The technical solution of this embodiment can automatically conduct chromosome data transmission between non-matching systems according to the configuration information, improve the data transmission efficiency of non-matching systems, shorten the chromosome karyotype analysis time, and enhance the accuracy and working efficiency of chromosome scanning and analysis.

[0131] The chromosome specimen processing device provided by the embodiment of the present invention can execute the chromosome specimen processing method provided by any embodiment of the present invention, and has corresponding functional modules and beneficial effects for executing the method.

[0132] It should be noted that the various units and modules included in the above system are only divided according to functional logic, but are not limited to the above division, as long as the corresponding functions can be realized; in addition, the specific names of the functional units are only for the convenience of mutual distinction and are not used to limit the protection scope of the embodiments of the present invention.

[0133] Embodiment 4

[0134] Figure 7 It is a schematic structural diagram of an electronic device provided by an embodiment of the present invention. Figure 7 It shows a block diagram of an exemplary electronic device 40 suitable for implementing the implementation manner of the embodiment of the present invention. Figure 7 The displayed electronic device 40 is only an example and should not bring any limitation to the functions and usage scope of the embodiments of the present invention.

[0135] As Figure 7 shown, the electronic device 40 is presented in the form of a general-purpose computing device. The components of the electronic device 40 may include but are not limited to: one or more processors or processing units 401, a system memory 402, and a bus 403 connecting different system components (including the system memory 402 and the processing unit 401).

[0136] The bus 403 represents one or more of several types of bus structures, including a memory bus or a memory controller, a peripheral bus, a graphics acceleration port, a processor, or a local bus using any bus structure in a variety of bus structures. For example, these architectures include but are not limited to Industry Standard Architecture (ISA) bus, Micro Channel Architecture (MAC) bus, Enhanced ISA bus, Video Electronics Standards Association (VESA) local bus, and Peripheral Component Interconnect (PCI) bus.

[0137] The electronic device 40 typically includes a variety of computer system-readable media. These media can be any available media accessible by the electronic device 40, including volatile and non-volatile media, removable and non-removable media.

[0138] The system memory 402 may include computer system-readable media in the form of volatile memory, such as random access memory (RAM) 404 and / or cache memory 405. The electronic device 40 may further include other removable / non-removable, volatile / non-volatile computer system storage media. By way of example only, a storage system 406 may be used for reading and writing non-removable, non-volatile magnetic media ( Figure 7 not shown, typically referred to as a "hard disk drive"). Although Figure 7Not shown in the figure, a disk drive for reading and writing to a removable non-volatile disk (such as a "floppy disk") and an optical disk drive for reading and writing to a removable non-volatile optical disk (such as a CD-ROM, DVD-ROM or other optical medium) can be provided. In these cases, each drive can be connected to the bus 403 through one or more data medium interfaces. The memory 402 can include at least one program product having a set (such as at least one) of program modules configured to perform the functions of the embodiments of the present invention.

[0139] A program / utility 404 having a set (at least one) of program modules 407 can be stored, for example, in the memory 402. Such program modules 407 include, but are not limited to, an operating system, one or more application programs, other program modules, and program data. Each or some combination of these examples may include the implementation of a network environment. The program modules 407 generally perform the functions and / or methods in the embodiments described in the present invention.

[0140] The electronic device 40 can also communicate with one or more external devices 409 (such as a keyboard, a pointing device, a display 410, etc.), and can also communicate with one or more devices that enable a user to interact with the electronic device 40, and / or communicate with any device that enables the electronic device 40 to communicate with one or more other computing devices (such as a network card, a modem, etc.). Such communication can be carried out through the input / output (I / O) interface 411. Moreover, the electronic device 40 can also communicate with one or more networks (such as a local area network (LAN), a wide area network (WAN), and / or a public network, such as the Internet) through the network adapter 412. As shown in the figure, the network adapter 412 communicates with other modules of the electronic device 40 through the bus 403. It should be understood that although Figure 7 not shown in the figure, other hardware and / or software modules can be used in combination with the electronic device 40, including but not limited to: microcode, device drivers, redundant processing units, external disk drive arrays, RAID systems, tape drives, and data backup storage systems, etc.

[0141] The processing unit 401 executes various functional applications and page processing by running the programs stored in the system memory 402, such as implementing the chromosome specimen processing method provided by the embodiments of the present invention.

[0142] Embodiment Five

[0143] The embodiments of the present invention also provide a storage medium containing computer-executable instructions, and the computer-executable instructions are used to execute a chromosome specimen processing method when executed by a computer processor. The method includes:

[0144] In response to a first triggering operation, at least one metaphase scan image of the target chromosome specimen scanned in the first system is synchronized to the second system based on target configuration information;

[0145] For the at least one metaphase scan image, based on a pre-trained target cutting and arranging model, a chromosome karyotype map corresponding to the metaphase scan image is determined; wherein, the target cutting and arranging model is obtained by training with multiple groups of training sample sets, and the multiple groups of training sample sets at least include a first training sample set, a second training sample set, and a third training sample set; the first training sample set includes first chromosome karyotype maps corresponding to multiple first chromosome specimens in the same region, each first chromosome specimen corresponding to multiple first chromosome karyotype maps, and the multiple first chromosome karyotype maps include a preset number of correct chromosome karyotype maps; the second training sample set includes second chromosome karyotype maps corresponding to multiple second chromosome specimens in the same region, each second chromosome specimen corresponding to multiple second chromosome karyotype maps, and the multiple second chromosome karyotype maps are all correct chromosome karyotype maps; the third training sample set includes third chromosome karyotype maps corresponding to multiple third chromosome specimens in at least two different regions, each third chromosome specimen corresponding to multiple third chromosome karyotype maps, and the multiple third chromosome karyotype maps are all correct chromosome karyotype maps;

[0146] Based on the chromosome karyotype map corresponding to the at least one metaphase scan image, a chromosome analysis result of the target object to which the chromosome specimen belongs is determined.

[0147] The computer storage medium of the embodiments of the present invention can adopt any combination of one or more computer-readable media. The computer-readable medium can be a computer-readable signal medium or a computer-readable storage medium. The computer-readable storage medium can be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the above. More specific examples (a non-exhaustive list) of the computer-readable storage medium include: an electrical connection having one or more wires, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the above. In this document, the computer-readable storage medium can be any tangible medium that contains or stores a program, and this program can be used by or combined with an instruction execution system, apparatus, or device.

[0148] A computer-readable signal medium can include a data signal propagated in a baseband or as part of a carrier wave, which carries computer-readable program code. Such a propagated data signal can take various forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the above. The computer-readable signal medium can also be any computer-readable medium other than a computer-readable storage medium, which can send, propagate, or transmit a program for use by or in conjunction with an instruction execution system, apparatus, or device.

[0149] The program code contained on a computer-readable medium can be transmitted by any appropriate medium, including - but not limited to - wireless, wire, optical fiber cable, RF, etc., or any suitable combination of the above.

[0150] The computer program code for performing the operations of the embodiments of the present invention can be written in one or more programming languages or combinations thereof. The programming languages include object-oriented programming languages - such as Java, Smalltalk, C++, and also include conventional procedural programming languages - such as the "C" language or similar programming languages. The program code can be executed entirely on the user's computer, partially on the user's computer, executed as an independent software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In the case of a remote computer, the remote computer can be connected to the user's computer through any type of network - including a local area network (LAN) or a wide area network (WAN) - or, it can be connected to an external computer (e.g., by using an Internet service provider to connect through the Internet).

[0151] Note that the above is only the preferred embodiment of the present invention and the applied technical principles. Those skilled in the art will understand that the present invention is not limited to the specific embodiments here. Various obvious changes, re-adjustments, and substitutions can be made by those skilled in the art without departing from the protection scope of the present invention. Therefore, although the present invention has been described in more detail through the above embodiments, the present invention is not limited to the above embodiments. Without departing from the concept of the present invention, it can also include more other equivalent embodiments, and the scope of the present invention is determined by the scope of the appended claims.

Claims

1. A method for processing chromosome specimens, characterized in that: include: In response to the first trigger operation, synchronizing at least one mitotic phase scan image of the target chromosome specimen scanned by the first system to the second system based on the target configuration information; For the at least one cleavage phase scan image, based on a pre-trained target cutting arrangement model, determine the chromosome karyotype map corresponding to the cleavage phase scan image; wherein the target cutting arrangement model is obtained by training with multiple sets of training sample sets, and the multiple sets of training sample sets at least include a first training sample set, a second training sample set, and a third training sample set; the first training sample set includes first chromosome karyotype maps corresponding to multiple first chromosome specimens in the same region, each first chromosome specimen corresponds to multiple first chromosome karyotype maps, and the multiple first chromosome karyotype maps include a preset number of correct chromosome karyotype maps; the second training sample set includes second chromosome karyotype maps corresponding to multiple second chromosome specimens in the same region, each of the second chromosome specimens corresponds to multiple second chromosome karyotype maps, and the multiple second chromosome karyotype maps are all correct chromosome karyotype maps; the third training sample set includes third chromosome karyotype maps corresponding to multiple third chromosome specimens in at least two different regions, each of the third chromosome specimens corresponds to multiple third chromosome karyotype maps, and the multiple third chromosome karyotype maps are all correct chromosome karyotype maps; Based on the chromosome karyotype diagram corresponding to the at least one mitotic phase scanning image, a chromosome analysis result of the target object to which the chromosome specimen belongs is determined.

2. The method according to claim 1, characterized in that Before the responding to the first trigger operation, the method further includes: In response to an editing operation on at least one preset configuration item, determining at least one configuration item information corresponding to the target chromosome specimen; wherein the at least one preset configuration item includes: a source file path configuration item corresponding to the first system, a target file path configuration item corresponding to the second system, a test item identification code configuration item, and a specimen identification code configuration item; Based on the at least one configuration item information, target configuration information corresponding to the target chromosome sample is determined.

3. The method according to claim 2, characterized in that The target configuration information includes at least one of a source file path, a target file path, a test item identification code, and a specimen identification code. The method of synchronizing at least one mitotic phase scan image of the target chromosome specimen scanned by the first system to the second system based on the target configuration information includes: The inspection item identification code and the specimen identification code are concatenated to obtain a target folder name; Based on the source file path, the target folder name and the target file path, at least one mitotic phase scan image of the target chromosome specimen scanned by the first system is synchronized to the second system.

4. The method according to claim 3, characterized in that The step of synchronizing at least one mitotic phase scan image of the target chromosome specimen scanned by the first system to the second system based on the source file path, the target folder name, and the target file path includes: Based on the source file path and the target folder name, searching the first system for a first folder associated with the target folder name; Parsing the first folder layer by layer to obtain at least one split phase scan image file consistent with a preset file suffix; A second folder is created in the target file path of the second system, and the at least one split phase scan image file is copied to the second folder of the second system.

5. The method according to claim 1, characterized in that The method further includes: training to obtain the target cutting arrangement model, including: Training a first cutting arrangement model based on the first training sample set, and preliminarily adjusting model parameters of the first cutting arrangement model to obtain a second cutting arrangement model; Training a second cutting arrangement model based on the second training sample set, and adjusting the model parameters of the second cutting arrangement model for a second time to obtain a third cutting arrangement model; The third cutting arrangement model is trained based on the third training sample set, and the model parameters of the third cutting arrangement model are adjusted for the third time to obtain a target cutting arrangement model.

6. The method according to claim 1, characterized in that The method further comprises: Based on the identification code scanning device on the first system, the identification code at the preset position of the target chromosome specimen is scanned and processed to obtain the specimen collection information corresponding to the target chromosome specimen; wherein the specimen collection information at least includes the specimen collection location and the specimen collection time; Based on the specimen collection information, a target scanning parameter template is determined from at least one pre-configured scanning parameter template; wherein the scanning parameter template includes a preset parameter value corresponding to at least one scanning parameter item, and the target scanning parameter template includes a target low-power microscope parameter template and a target high-power microscope parameter template; Based on the low-power microscope scanning device on the first system and the target low-power microscope parameter template, the target chromosome specimen is preliminarily scanned to obtain a plurality of first specimen scanning images; Screening and processing the plurality of first specimen scan images based on a preset image classifier to obtain at least one second specimen scan image; Based on the high-power microscope scanning device on the first system, the target scanning position corresponding to the second specimen scanning image, and the target high-power microscope parameter template, the target chromosome specimen is scanned twice to obtain a plurality of third specimen scanning images; At least one mitotic phase scan image of the target chromosome specimen is determined based on the plurality of third specimen scan images.

7. The method according to claim 6, characterized in that The specimen collection information also includes: a specimen identification code and a test item identification code, and the method further includes: Based on the specimen identification code and / or the test item identification code of the target chromosome specimen, a target folder is created on the first system to store the at least one mitotic phase scan image in the target folder.

8. The method according to claim 1, characterized in that The method further comprises: Based on the at least one mitotic phase scan image, the corresponding chromosome karyotype diagram and the chromosome analysis result, a target report corresponding to the target object is generated and displayed.

9. A chromosome specimen processing device, characterized in that: include: A data synchronization module, for synchronizing at least one mitotic phase scan image of a target chromosome specimen scanned by the first system to a second system based on target configuration information in response to a first trigger operation; A karyotype determination module is used to determine the chromosome karyotype corresponding to the mitotic phase scan image based on a pre-trained target cutting arrangement model for at least one mitotic phase scan image; wherein the target cutting arrangement model is obtained by training multiple sets of training sample sets, and the multiple sets of training sample sets at least include a first training sample set, a second training sample set, and a third training sample set; the first training sample set includes first chromosome karyotypes corresponding to multiple first chromosome specimens in the same region, each of which corresponds to multiple first chromosome karyotypes, and the multiple first chromosome karyotypes include a preset number of correct chromosome karyotypes; the second training sample set includes second chromosome karyotypes corresponding to multiple second chromosome specimens in the same region, each of which corresponds to multiple second chromosome karyotypes, and the multiple second chromosome karyotypes are all correct chromosome karyotypes; the third training sample set includes third chromosome karyotypes corresponding to multiple third chromosome specimens in at least two different regions, each of which corresponds to multiple third chromosome karyotypes, and the multiple third chromosome karyotypes are all correct chromosome karyotypes; The analysis result determination module is used to determine the chromosome analysis result of the target object to which the chromosome sample belongs based on the chromosome karyotype diagram corresponding to the at least one mitotic phase scanning image.

10. An electronic device, characterized in that: The electronic device comprises: one or more processors; A memory for storing one or more programs; When the one or more programs are executed by the one or more processors, the one or more processors implement the chromosome sample processing method as described in any one of claims 1-8.

Images