On-line quality detection device and detection method for consolidating body resistance and prolonging pill finished product

Abstract

The invention discloses an on-line quality detection device and detection method for a consolidating and life-prolonging pill finished product, and relates to the technical field of medicine quality detection.The device comprises a shell, a lower grinding mechanism is arranged at the bottom of the inner side of the shell, a driving mechanism is arranged at the top of the inner side of the shell, and an upper grinding mechanism is arranged at the bottom end of the driving mechanism; the left side of the top and the left side of the bottom of the upper grinding mechanism are jointly provided with a dry powder adding mechanism. The driving mechanism drives the upper grinding mechanism to move downwards so as to be matched with the lower grinding mechanism to crush and grind a to-be-detected consolidation and life-prolonging pill finished product, then due to blocking of the lower grinding mechanism, the driving mechanism drives the dry powder adding mechanism, and then dry powder is periodically and quantitatively added. According to the device, dry powder can be automatically added for multiple times, manual operation is not needed while the automation degree is higher, grinding operation does not need to be stopped in the adding process while manpower is saved, and then the preparation efficiency of the to-be-detected consolidating and life-prolonging pill treating fluid is effectively improved.

Description

Technical Field

[0001] The present invention relates to the technical field of drug quality detection, and particularly relates to an on-line detection device and a detection method for the finished product quality of Guben Yanling Pills. Background Art

[0002] Guben Yanling Pills, also known as Centennial Pills, have the effects of strengthening the root and cultivating the primordial qi, nourishing yin and strengthening yang, replenishing marrow and filling essence, and strengthening muscles and bones. They are used for consumptive fatigue, low back pain and physical fatigue, palpitations and insomnia, emaciated skin, premature whitening of hair and beard, irregular menstruation, loss of appetite, dementia, sexual senility, hypertension, diabetes, and menopausal syndrome, etc. It contains many precious medicinal materials such as Salvia miltiorrhiza, Cistanche deserticola, and Panax ginseng.

[0003] The invention patent with the authorization announcement number CN 113640452 B discloses a detection method for Guben Yanling Pills. Among them, the active ingredients in Guben Yanling Pills are extracted by adding an extraction agent and a desiccant to improve the extraction rate of the active ingredients and prepare for subsequent detection; when detecting, the preparation of the medicinal material identification solution is carried out to compare and verify whether the corresponding ingredients exist in Guben Yanling Pills.

[0004] When preparing the treatment solution of the Guben Yanling Pills to be detected in the above scheme, it is necessary to take the finished product of the Guben Yanling Pills to be detected and put it into a mortar for grinding and pulverizing, and then add dry powder to the mortar. The dry powder needs to be added in four times, and it is fully ground to make the powder of the Guben Yanling Pills to be detected and the dry powder evenly mixed.

[0005] However, after the above method is actually applied by those skilled in the art, it is found that there are still some disadvantages. The more obvious one is that when adding the dry powder, it needs to be manually added. The amount added each time is not accurate enough, and the grinding operation needs to be stopped during the addition process, which has a great impact on the preparation efficiency of the treatment solution of the Guben Yanling Pills to be detected.

[0006] Therefore, it is very necessary to invent an on-line detection device and a detection method for the finished product quality of Guben Yanling Pills to solve the above problems. Summary of the Invention

[0007] The object of the present invention is to provide an online quality detection device and method for the finished product of Guben Yanling Pills. The device is provided with a lower grinding mechanism, a driving mechanism, an upper grinding mechanism and a dry powder adding mechanism, so that the driving mechanism drives the upper grinding mechanism to move downward to cooperate with the lower grinding mechanism to crush and grind the finished product of Guben Yanling Pills to be tested. Subsequently, due to the obstruction of the lower grinding mechanism, the driving mechanism drives the dry powder adding mechanism to perform periodic quantitative addition of dry powder. In addition, during the dry powder adding process, the upper grinding mechanism continuously triggers the dry powder adding mechanism to ensure the normal output of dry powder, so as to solve the problem proposed in the above background technology that when adding dry powder, manual addition is required, the amount added each time is not accurate enough, and the grinding operation needs to be stopped during the adding process, which has a great impact on the preparation efficiency of the processing liquid of Guben Yanling Pills to be tested.

[0008] To achieve the above object, the present invention provides the following technical solution: an online quality detection device for finished product of Guben Yanling Pills, comprising a shell, a lower grinding mechanism is arranged at the bottom of the inner side of the shell, a driving mechanism is arranged at the top of the inner side of the shell, an upper grinding mechanism is arranged at the bottom of the driving mechanism, and a dry powder adding mechanism is arranged on the left side of the top and the left side of the bottom of the upper grinding mechanism;

[0009] The driving mechanism drives the upper grinding mechanism to move downward to cooperate with the lower grinding mechanism to crush and grind the finished product of the Guben Yanling Pills to be tested. Subsequently, due to the obstruction of the lower grinding mechanism, the driving mechanism drives the dry powder adding mechanism to perform periodic quantitative addition of dry powder. In addition, during the dry powder adding process, the upper grinding mechanism continuously triggers the dry powder adding mechanism to ensure the normal output of the dry powder.

[0010] Preferably, the lower grinding mechanism comprises a grinding seat, an avoidance groove and a grinding groove;

[0011] The avoidance groove is arranged on the top of the grinding seat, and the grinding groove is arranged at the center of the top of the avoidance groove.

[0012] Preferably, the driving mechanism comprises a reciprocating screw, a driving motor, a square driving slot, an outer sleeve, a first spring and an inner sleeve;

[0013] The reciprocating screw passes through the top of the outer shell and is rotatably connected to the outer shell through a bearing. The driving motor is fixedly arranged on the top of the outer shell and is transmission-connected to the reciprocating screw. The square driving groove is opened at the bottom end of the reciprocating screw. The outer sleeve, the first spring and the inner sleeve are sequentially sleeved on the outside of the reciprocating screw from top to bottom. The outer sleeve is transmission-connected to the reciprocating screw. The first spring is fixedly connected between the outer sleeve and the inner sleeve. The inner sleeve is slidably connected to the reciprocating screw and is slidably arranged on the inside of the outer sleeve.

[0014] Preferably, the driving mechanism further comprises an outer sleeve plate and a one-way screw;

[0015] The outer jacket plate is fixedly sleeved at the outer bottom of the outer sleeve pipe, and the one-way screw rod is fixedly arranged at the left bottom of the outer jacket plate.

[0016] Preferably, the upper grinding mechanism includes a sealing disc, a rotating shaft, a square driving column, a dialing block and a grinding block;

[0017] The sealing disc is fixedly arranged at the bottom end of the inner sleeve pipe. The rotating shaft penetrates through the sealing disc and is rotationally connected with the sealing disc through a bearing. The square driving column is fixedly arranged at the top end of the rotating shaft and is slidably arranged inside the square driving groove in the vertical direction. The dialing block is fixedly arranged on the side surface of the rotating shaft, and the grinding block is fixedly arranged at the bottom end of the rotating shaft.

[0018] Preferably, the dry powder adding mechanism includes a threaded sleeve, a dry powder storage cylinder, a blocking disc and an adding channel;

[0019] The threaded sleeve and the dry powder storage cylinder are fixedly penetrated from outside to inside at the left top of the sealing disc. The blocking disc is fixedly sleeved at the outer bottom of the threaded sleeve, and the adding channel is penetrated at the left top of the blocking disc.

[0020] Preferably, the dry powder adding mechanism further includes a guide rod, a moving block, an arc-shaped arm, a knocking block and a second spring;

[0021] The guide rod is fixedly arranged at the right bottom of the dry powder storage cylinder. The moving block is slidably sleeved on the outer side of the guide rod. The arc-shaped arm is fixedly arranged on the back surface of the moving block. The knocking block is fixedly arranged at the end of the knocking block and is attached to the outer wall of the dry powder storage cylinder. The second spring is fixedly connected between the threaded sleeve and the knocking block.

[0022] The present invention also discloses a method for on-line detection of the finished product quality of Guben Yanling Pills, which is realized by using the above-mentioned on-line detection device for the finished product quality of Guben Yanling Pills. The method specifically includes the following steps:

[0023] S1. Prepare Salvia miltiorrhiza identification solution, Cistanche deserticola identification solution, Cuscuta chinensis identification solution, Ophiopogon japonicus identification solution, Panax ginseng identification solution, Schisandra chinensis identification solution, Asparagus cochinchinensis identification solution and Rehmannia glutinosa Libosch. f. hueichingensis (Chao) Hsiao & Keng identification solution. Use a capillary glass tube to pick up each identification solution and dot it on multiple silica gel G plates. After drying, put them into the chromatography solutions corresponding to the medicinal materials for plate climbing respectively. After the plate climbing is finished, take them out and dry them. Observe the developed spots under different lights and take pictures and input them into the computer as detection references;

[0024] S2. Place the finished Guben Yangling Pills to be tested inside the grinding groove. Add the dry powder to be added into the inside of the dry powder storage cylinder through the opening at the top of the dry powder storage cylinder. Due to the blocking of the blocking disc, the dry powder will not directly fall out from the bottom of the dry powder storage cylinder. Start the driving motor. After the driving motor starts, it drives the reciprocating screw to rotate. When the reciprocating screw rotates, it drives the outer sleeve to descend. During the descent of the outer sleeve, the inner sleeve is driven to descend through the first spring, and the one-way screw is driven to descend through the outer plate.

[0025] S3. When the reciprocating screw rotates, it drives the square driving column to rotate through the square driving groove. When the square driving column rotates, it drives the dial and the grinding block to rotate through the rotating shaft. When the inner sleeve descends, it drives the sealing disc to descend. During the descent of the sealing disc, the grinding block is driven to descend through the rotating shaft.

[0026] S4. When the descending distance of the outer sleeve reaches the first threshold, the bottom of the grinding block contacts the finished Guben Yangling Pills to be tested inside the grinding groove. Subsequently, as the outer sleeve continues to descend, the grinding block squeezes and crushes the finished Guben Yangling Pills to be tested.

[0027] S5. When the descending distance of the outer sleeve reaches the second threshold, the bottom of the sealing disc contacts the top of the grinding seat. At this time, the grinding block continues to rotate inside the grinding groove, and then cooperates with the inner wall of the grinding groove to grind the crushed finished Guben Yangling Pills to be tested. In addition, due to the blocking of the grinding seat, the sealing disc cannot continue to descend. Subsequently, as the outer sleeve continues to descend, the first spring is continuously compressed, and at the same time, the outer plate continues to drive the one-way screw to descend.

[0028] S6. When the descending distance of the outer sleeve reaches the third threshold, the one-way screw enters the inside of the threaded sleeve. Subsequently, as the one-way screw continues to descend, the threaded sleeve rotates continuously driven by the one-way screw. During the rotation of the threaded sleeve, the blocking disc rotates synchronously. When the blocking disc rotates, it drives the adding channel to periodically pass under the dry powder storage cylinder. When the adding channel is located under the dry powder storage cylinder, the dry powder inside the dry powder storage cylinder falls into the grinding groove through the adding channel.

[0029] S7. After the dry powder falls into the grinding groove, the continuously rotating rotating shaft drives the grinding block to grind and mix the dry powder and the ground finished Guben Yangling Pills to be tested. At the same time, due to the rotation of the rotating shaft, the dial periodically pushes the moving block. After being pushed, the moving block moves leftward on the outside of the guide rod, and at the same time drives the knocking block to compress the second spring through the arc-shaped arm. Subsequently, when the dial moves away, the compressed second spring pushes the knocking block, so that the knocking block knocks on the outer wall of the dry powder storage cylinder, so that the dry powder inside the dry powder storage cylinder is stably piled up at the bottom inside the dry powder storage cylinder at the position waiting for discharging.

[0030] S8, when the outer sleeve descends to the fourth threshold, the outer sleeve moves to the bottom of the reciprocating thread on the outside of the reciprocating screw, and then as the reciprocating screw continues to rotate, the outer sleeve moves upward and resets. When the outer sleeve moves upward to the fifth threshold, the addition of dry powder is completed. As the reciprocating screw continues to rotate, the compressed outer sleeve gradually resets. When the outer sleeve moves upward to the sixth threshold, the outer sleeve arrives at the initial position on the outside of the reciprocating screw, that is, the top of the reciprocating thread on the outside of the reciprocating screw. At this time, the drive motor is stopped, and a mixture is formed inside the grinding tank.

[0031] S9, take 5 parts of the above mixture and put them into a beaker, add 45-50 parts of the extract thereto, put it on a shaking table for shaking mixing, wherein the shaking time is 30 minutes, the temperature is 45°C, filter, obtain filter residue and filtrate a, add 30-35 parts of the extract to the filter residue, put it into a shaking table for shaking, wherein the shaking time is 20 minutes, the temperature is 43°C, filter, collect the filtrate, obtain filtrate b, mix filtrate a and filtrate b, and set aside;

[0032] The filtrate was centrifuged, 30-40 portions of the clarified supernatant were taken and placed in a conical flask, and the conical flask was placed in a water bath for water bath heating, the water bath temperature was 100°C, the water bath heating time was 5 hours, and when the water bath heating was turned on, the condensation reflux device was turned on at the same time. After the reaction was completed, the conical flask was taken out, and the bottle mouth was quickly sealed with a sealing film, and it was allowed to stand at room temperature for use;

[0033] The solution in the above-mentioned processed conical flask is poured into a separating funnel, and ethyl acetate is added thereto for extraction, a capillary glass tube is used to point the aqueous solution, and it is point on a silica gel G plate, a hair dryer is utilized to dry, it is placed under a 254 mm ultraviolet lamp, and it is observed whether there is a color developing point, if there is, then continue to extract, if not, then prove that the extraction ends, merge all organic phases in the extraction process, anhydrous magnesium sulfate is added thereto, until anhydrous magnesium sulfate has a powder state in the solution, then it is subjected to suction filtration, and the filtrate is collected, and the filtrate is spin-dried by a spin evaporator, and residue is collected for standby use;

[0034] Take 0.5 parts of the above residue, add anhydrous ethanol to dissolve it until the residue is completely dissolved, add 0.02% of the solution volume of the antioxidant color-reducing agent, shake and mix evenly, and obtain the treated solution of the Guben Yanling Pills to be tested;

[0035] S10. Use a capillary glass tube to pick up the treatment solution of the solid Guben Yiling Pills to be tested and spot it on multiple silica gel G plates. After drying, place them separately into the chromatography solutions of the corresponding medicinal materials for plate development. After the plate development is completed, take them out and dry them. Observe the developed spots under different lights and compare them online with the photos of the developed spots of each identification solution in the computer. If the developed spots of the treatment solution of the solid Guben Yiling Pills to be tested match the developed spots of all the above identification solutions, it is confirmed as qualified Guben Yiling Pills.

[0036] Technical effects and advantages of the present invention:

[0037] In the present invention, a lower grinding mechanism, a driving mechanism, an upper grinding mechanism and a dry powder adding mechanism are provided, so that the driving mechanism drives the upper grinding mechanism to move downwards to cooperate with the lower grinding mechanism to crush and grind the finished product of the solid Guben Yiling Pills to be tested. Subsequently, due to the blockage of the lower grinding mechanism, the driving mechanism drives the dry powder adding mechanism, and then periodically adds a fixed amount of dry powder. In addition, during the dry powder adding process, the upper grinding mechanism continuously triggers the dry powder adding mechanism to ensure the normal output of the dry powder. Compared with the same type of devices and methods in the prior art, the present invention can automatically complete the addition of dry powder multiple times, with higher automation and without manual operation. While saving manpower, the grinding operation does not need to be stopped during the adding process, thereby effectively improving the preparation efficiency of the treatment solution of the solid Guben Yiling Pills to be tested. Description of the Drawings

[0038] Figure 1 It is a schematic diagram of the overall structure of the present invention.

[0039] Figure 2 It is a schematic diagram of the structure of the lower grinding mechanism of the present invention.

[0040] Figure 3 It is a schematic diagram of the structure of the driving mechanism of the present invention.

[0041] Figure 4 It is a schematic diagram of the structure of the upper grinding mechanism of the present invention.

[0042] Figure 5 It is a schematic diagram of the structure of the dry powder adding mechanism of the present invention.

[0043] In the figure: 1. shell; 2. lower grinding mechanism; 21. grinding seat; 22. avoidance groove; 23. grinding groove; 3. driving mechanism; 31. reciprocating screw; 32. driving motor; 33. square driving groove; 34. outer sleeve; 35. first spring; 36. inner sleeve; 37. outer sleeve plate; 38. one-way screw; 4. upper grinding mechanism; 41. sealing disk; 42. rotating shaft; 43. square driving column; 44. shifting block; 45. grinding block; 5. dry powder adding mechanism; 51. threaded sleeve; 52. dry powder storage cylinder; 53. blocking disk; 54. adding channel; 55. guide rod; 56. moving block; 57. arc arm; 58. knocking block; 59. second spring. DETAILED DESCRIPTION

[0044] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] Example 1

[0046] The present invention provides Figures 1-5 The device for online quality inspection of finished products of Guben Yanling Pills shown in the figure comprises a shell 1, a lower grinding mechanism 2 is arranged at the bottom of the inner side of the shell 1, a driving mechanism 3 is arranged at the top of the inner side of the shell 1, an upper grinding mechanism 4 is arranged at the bottom end of the driving mechanism 3, and a dry powder adding mechanism 5 is arranged on the left side of the top and the left side of the bottom of the upper grinding mechanism 4;

[0047] The driving mechanism 3 drives the upper grinding mechanism 4 to move downward to cooperate with the lower grinding mechanism 2 to crush and grind the finished product of the Guben Yanling Pills to be tested. Subsequently, due to the obstruction of the lower grinding mechanism 2, the driving mechanism 3 drives the dry powder adding mechanism 5 to perform periodic quantitative addition of dry powder. In addition, during the dry powder adding process, the upper grinding mechanism 4 continuously triggers the dry powder adding mechanism 5 to ensure the normal output of the dry powder.

[0048] like Figure 2 As shown, the lower grinding mechanism 2 includes a grinding seat 21 , an avoidance groove 22 and a grinding groove 23 , wherein the avoidance groove 22 is opened at the top of the grinding seat 21 , and the grinding groove 23 is opened at the center of the top of the avoidance groove 22 .

[0049] like Figure 3As shown in the figure, the driving mechanism 3 includes a reciprocating screw 31, a driving motor 32, a square driving groove 33, an outer sleeve 34, a first spring 35, an inner sleeve 36, an outer plate 37 and a one-way screw 38. Among them, the reciprocating screw 31 penetrates through the top of the housing 1 and is rotatably connected to the housing 1 through a bearing. The driving motor 32 is fixedly arranged on the top of the housing 1 and is in transmission connection with the reciprocating screw 31. The square driving groove 33 is opened at the bottom end of the reciprocating screw 31. The outer sleeve 34, the first spring 35 and the inner sleeve 36 are sleeved on the outside of the reciprocating screw 31 in sequence from top to bottom. The outer sleeve 34 is in transmission connection with the reciprocating screw 31. The first spring 35 is fixedly connected between the outer sleeve 34 and the inner sleeve 36. The inner sleeve 36 is slidably connected to the reciprocating screw 31 and is slidably arranged inside the outer sleeve 34. The outer plate 37 is fixedly sleeved on the outside bottom of the outer sleeve 34. The one-way screw 38 is fixedly arranged on the left side of the bottom of the outer plate 37.

[0050] By setting the above structure, it is convenient for the driving motor 32 to drive the reciprocating screw 31 to rotate after starting. When the reciprocating screw 31 rotates, it drives the outer sleeve 34 to descend. During the descent of the outer sleeve 34, the inner sleeve 36 is driven to descend through the first spring 35, and the one-way screw 38 is driven to descend through the outer plate 37.

[0051] As Figure 4 shown in the figure, the upper grinding mechanism 4 includes a sealing disk 41, a rotating shaft 42, a square driving column 43, a dial block 44 and a grinding block 45. Among them, the sealing disk 41 is fixedly arranged at the bottom end of the inner sleeve 36. The rotating shaft 42 penetrates through the sealing disk 41 and is rotatably connected to the sealing disk 41 through a bearing. The square driving column 43 is fixedly arranged at the top end of the rotating shaft 42 and is slidably arranged inside the square driving groove 33 in the vertical direction. The dial block 44 is fixedly arranged on the side surface of the rotating shaft 42. The grinding block 45 is fixedly arranged at the bottom end of the rotating shaft 42.

[0052] By setting the above structure, when the square driving groove 33 rotates, it drives the square driving column 43 to rotate. When the square driving column 43 rotates, it drives the dial block 44 and the grinding block 45 to rotate through the rotating shaft 42. When the inner sleeve 36 descends, it drives the sealing disc 41 to descend. During the descent of the sealing disc 41, it drives the grinding block 45 to descend through the rotating shaft 42 until the bottom of the grinding block 45 contacts the finished product of Guben Yanjing Pills to be tested on the inner side of the grinding groove 23. Subsequently, as the outer sleeve 34 continues to descend, the grinding block 45 squeezes and crushes the finished product of Guben Yanjing Pills to be tested. When the bottom of the sealing disc 41 contacts the top of the grinding seat 21, at this time, the grinding block 45 continues to rotate inside the grinding groove 23, and then cooperates with the inner wall of the grinding groove 23 to grind the crushed finished product of Guben Yanjing Pills to be tested. In addition, due to the blockage of the grinding seat 21, the sealing disc 41 cannot continue to descend. Subsequently, as the outer sleeve 34 continues to descend, the first spring 35 is continuously compressed, and at the same time, the outer sleeve plate 37 continues to drive the one-way screw 38 to descend.

[0053] As Figure 5 shown, the dry powder adding mechanism 5 includes a threaded sleeve 51, a dry powder storage cylinder 52, a blocking disc 53, an adding channel 54, a guide rod 55, a moving block 56, an arc-shaped arm 57, a knocking block 58 and a second spring 59. Among them, the threaded sleeve 51 and the dry powder storage cylinder 52 are fixedly arranged through the top left side of the sealing disc 41 from outside to inside in sequence. The blocking disc 53 is fixedly sleeved on the outer bottom of the threaded sleeve 51. The adding channel 54 is arranged through the top left side of the blocking disc 53. The guide rod 55 is fixedly arranged on the right bottom of the dry powder storage cylinder 52. The moving block 56 is slidably sleeved on the outer side of the guide rod 55. The arc-shaped arm 57 is fixedly arranged on the back of the moving block 56. The knocking block 58 is fixedly arranged at the end of the knocking block 58 and fits against the outer wall of the dry powder storage cylinder 52. The second spring 59 is fixedly connected between the threaded sleeve 51 and the knocking block 58.

[0054] By setting the above structure, the dry powder to be added can be added into the inner side of the dry powder storage barrel 52 from the top opening of the dry powder storage barrel 52. Due to the obstruction of the blocking disk 53, the dry powder will not fall out directly from the bottom of the dry powder storage barrel 52. When the one-way screw 38 enters the inner side of the threaded sleeve 51, as the one-way screw 38 continues to descend, the threaded sleeve 51 continues to rotate under the one-way screw 38. During the rotation of the threaded sleeve 51, the blocking disk 53 is driven to rotate synchronously. When the blocking disk 53 rotates, the adding channel 54 is driven to periodically pass under the dry powder storage barrel 52. When the adding channel 54 is located under the dry powder storage barrel 52, the dry powder inside the dry powder storage barrel 52 falls into the grinding barrel through the adding channel 54. Inside the grinding groove 23, after the dry powder falls into the grinding groove 23, the continuously rotating rotating shaft 42 drives the grinding block 45 to grind and mix the dry powder and the ground Guben Yanling Pills finished product to be tested. At the same time, due to the rotation of the rotating shaft 42, the shifting block 44 periodically pushes the moving block 56. After being pushed, the moving block 56 moves to the left outside the guide rod 55, and at the same time drives the knocking block 58 to compress the second spring 59 through the arc arm 57. Subsequently, when the shifting block 44 is moved away, the compressed second spring 59 pushes the knocking block 58, and then the knocking block 58 knocks the outer wall of the dry powder storage tube 52, so that the dry powder inside the dry powder storage tube 52 is stably accumulated at the inner bottom of the dry powder storage tube 52 to be discharged.

[0055] Example 2

[0056] The present invention also discloses a method for online quality detection of finished product of Guben Yanling Pills, which is implemented by using the above-mentioned online quality detection device of finished product of Guben Yanling Pills. The method specifically comprises the following steps:

[0057] S1. Prepare identification liquid of Danshen, identification liquid of Cistanche deserticola, identification liquid of Cuscuta australis, identification liquid of Ophiopogon japonicus, identification liquid of Panax ginseng, identification liquid of Schisandra chinensis, identification liquid of Asparagus cochinchinensis and identification liquid of Rehmannia glutinosa, use capillary glass tube to take each identification liquid and spot it on multiple silica gel G plates, put them into the chromatography liquid of corresponding medicinal materials respectively after drying, take them out and dry them after climbing the plates, observe the development points under different lighting conditions and take pictures and input them into the computer as a detection reference;

[0058] S2, place the finished product of Guben Yanling Pills to be tested inside the grinding tank 23, add the dry powder to be added into the inside of the dry powder storage tube 52 through the top opening of the dry powder storage tube 52, and the dry powder will not fall out directly from the bottom of the dry powder storage tube 52 due to the obstruction of the blocking plate 53, start the driving motor 32, and after the driving motor 32 is started, the reciprocating screw 31 is driven to rotate, and the reciprocating screw 31 drives the outer sleeve 34 to descend when rotating. During the descent of the outer sleeve 34, the inner sleeve 36 is driven to descend through the first spring 35, and the one-way screw 38 is driven to descend through the outer sleeve plate 37;

[0059] S3, when the reciprocating screw 31 rotates, the square drive column 43 is driven to rotate through the square drive slot 33, and when the square drive column 43 rotates, the shifting block 44 and the grinding block 45 are driven to rotate through the rotating shaft 42, and when the inner sleeve 36 descends, the sealing plate 41 is driven to descend, and during the descending process of the sealing plate 41, the grinding block 45 is driven to descend through the rotating shaft 42;

[0060] S4, when the outer sleeve 34 descends to a first threshold, the bottom of the grinding block 45 contacts the finished product of the Guben Yanling Pills to be tested inside the grinding groove 23, and as the outer sleeve 34 continues to descend, the grinding block 45 squeezes and crushes the finished product of the Guben Yanling Pills to be tested;

[0061] S5, when the outer sleeve 34 descends to a second threshold, the bottom of the sealing disk 41 contacts the top of the grinding seat 21, and the grinding block 45 rotates continuously inside the grinding groove 23, thereby cooperating with the inner wall of the grinding groove 23 to grind the crushed Guben Yanling Pills to be tested. In addition, due to the obstruction of the grinding seat 21, the sealing disk 41 cannot continue to descend. Subsequently, as the outer sleeve 34 continues to descend, the first spring 35 is continuously compressed, and the outer plate 37 continues to drive the one-way screw 38 to descend.

[0062] S6, when the outer sleeve 34 descends to a third threshold, the one-way screw 38 enters the inner side of the threaded sleeve 51, and as the one-way screw 38 continues to descend, the threaded sleeve 51 continues to rotate under the drive of the one-way screw 38, and the threaded sleeve 51 rotates to drive the blocking disk 53 to rotate synchronously, and the blocking disk 53 rotates to drive the adding channel 54 to periodically pass under the dry powder storage barrel 52. When the adding channel 54 is located under the dry powder storage barrel 52, the dry powder in the dry powder storage barrel 52 falls into the grinding tank 23 through the adding channel 54;

[0063] S7, after the dry powder falls into the grinding groove 23, the continuously rotating rotating shaft 42 drives the grinding block 45 to grind and mix the dry powder and the ground Guben Yanling Pills product to be tested. At the same time, due to the rotation of the rotating shaft 42, the shifting block 44 periodically pushes the moving block 56, and the moving block 56 moves to the left outside the guide rod 55 after being pushed, and at the same time drives the knocking block 58 to compress the second spring 59 through the arc arm 57. When the shifting block 44 is moved away, the compressed second spring 59 pushes the knocking block 58, and then the knocking block 58 knocks the outer wall of the dry powder storage tube 52, so that the dry powder inside the dry powder storage tube 52 is stably accumulated at the inner bottom of the dry powder storage tube 52 to be discharged;

[0064] S8, when the outer sleeve 34 descends to a fourth threshold, the outer sleeve 34 moves to the bottom of the reciprocating thread on the outside of the reciprocating screw 31, and then as the reciprocating screw 31 continues to rotate, the outer sleeve 34 moves upward and resets. When the outer sleeve 34 moves upward to a fifth threshold, the addition of dry powder is completed. Subsequently, as the reciprocating screw 31 continues to rotate, the compressed outer sleeve 34 gradually resets. When the outer sleeve 34 moves upward to a sixth threshold, the outer sleeve 34 arrives at the initial position on the outside of the reciprocating screw 31, that is, the top of the reciprocating thread on the outside of the reciprocating screw 31. At this time, the drive motor 32 is stopped, and a mixture is formed inside the grinding tank 23.

[0065] S9, take 5 parts of the above mixture and put them into a beaker, add 45-50 parts of the extract thereto, put it on a shaking table for shaking mixing, wherein the shaking time is 30 minutes, the temperature is 45°C, filter, obtain filter residue and filtrate a, add 30-35 parts of the extract to the filter residue, put it into a shaking table for shaking, wherein the shaking time is 20 minutes, the temperature is 43°C, filter, collect the filtrate, obtain filtrate b, mix filtrate a and filtrate b, and set aside;

[0066] The filtrate was centrifuged, 30-40 portions of the clarified supernatant were taken and placed in a conical flask, and the conical flask was placed in a water bath for water bath heating, the water bath temperature was 100°C, the water bath heating time was 5 hours, and when the water bath heating was turned on, the condensation reflux device was turned on at the same time. After the reaction was completed, the conical flask was taken out, and the bottle mouth was quickly sealed with a sealing film, and it was allowed to stand at room temperature for use;

[0067] The solution in the above-mentioned processed conical flask is poured into a separating funnel, and ethyl acetate is added thereto for extraction, a capillary glass tube is used to point the aqueous solution, and it is point on a silica gel G plate, a hair dryer is utilized to dry, it is placed under a 254 mm ultraviolet lamp, and it is observed whether there is a color developing point, if there is, then continue to extract, if not, then prove that the extraction ends, merge all organic phases in the extraction process, anhydrous magnesium sulfate is added thereto, until anhydrous magnesium sulfate has a powder state in the solution, then it is subjected to suction filtration, and the filtrate is collected, and the filtrate is spin-dried by a spin evaporator, and residue is collected for standby use;

[0068] Take 0.5 parts of the above residue, add anhydrous ethanol to dissolve it until the residue is completely dissolved, add 0.02% of the solution volume of the antioxidant color-reducing agent, shake and mix evenly, and obtain the treated solution of the Guben Yanling Pills to be tested;

[0069] S10. Use a capillary glass tube to pick up the treatment solution of the solid Guben Yiling Pills to be tested and spot it on multiple silica gel G plates. After drying, place them separately in the chromatography solutions of the corresponding medicinal materials for plate development. After the plate development is completed, take them out and dry. Observe the developed spots under different lights and compare them online with the photos of the developed spots of each identification solution in the computer. If the developed spots of the treatment solution of the solid Guben Yiling Pills to be tested match the developed spots of all the above identification solutions, it is confirmed as qualified Guben Yiling Pills.

[0070] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. An on-line detection device for the finished product quality of Guben Yanling Pills, characterized in that: The invention comprises a shell (1), a lower grinding mechanism (2) is arranged at the bottom of the inner side of the shell (1), a driving mechanism (3) is arranged at the top of the inner side of the shell (1), an upper grinding mechanism (4) is arranged at the bottom end of the driving mechanism (3), and a dry powder adding mechanism (5) is arranged on the left side of the top and the left side of the bottom of the upper grinding mechanism (4); The driving mechanism (3) drives the upper grinding mechanism (4) to move downward to cooperate with the lower grinding mechanism (2) to crush and grind the finished product of the Guben Yanling Pills to be tested. Subsequently, due to the obstruction of the lower grinding mechanism (2), the driving mechanism (3) drives the dry powder adding mechanism (5) to periodically add dry powder in a quantitative manner. In addition, during the process of adding dry powder, the upper grinding mechanism (4) continuously triggers the dry powder adding mechanism (5) to ensure the normal output of dry powder.

2. The on-line detection device for the finished product quality of Guben Yanling Pills according to claim 1, characterized in that: The lower grinding mechanism (2) comprises a grinding seat (21), an avoidance groove (22) and a grinding groove (23); The avoidance groove (22) is opened at the top of the grinding seat (21), and the grinding groove (23) is opened at the center of the top of the avoidance groove (22).

3. The online detection device for the finished product quality of Guben Yanling Pills according to claim 2, wherein: The driving mechanism (3) comprises a reciprocating screw (31), a driving motor (32), a square driving slot (33), an outer sleeve (34), a first spring (35) and an inner sleeve (36); The reciprocating screw (31) passes through the top of the outer shell (1) and is rotatably connected to the outer shell (1) via a bearing; the driving motor (32) is fixedly arranged at the top of the outer shell (1) and is transmission-connected to the reciprocating screw (31); the square driving groove (33) is opened at the bottom of the reciprocating screw (31); the outer sleeve (34), the first spring (35) and the inner sleeve (36) are sequentially sleeved and arranged on the outside of the reciprocating screw (31) from top to bottom; the outer sleeve (34) is transmission-connected to the reciprocating screw (31); the first spring (35) is fixedly connected between the outer sleeve (34) and the inner sleeve (36); the inner sleeve (36) is slidably connected to the reciprocating screw (31) and is slidably arranged on the inside of the outer sleeve (34).

4. An on-line detection device for the finished product quality of Guben Yanling Pills according to claim 3, characterized in that: The driving mechanism (3) further comprises an outer sleeve plate (37) and a one-way screw (38); The outer sleeve plate (37) is fixedly sleeved on the outer bottom of the outer sleeve (34), and the one-way screw (38) is fixedly arranged on the left side of the bottom of the outer sleeve plate (37).

5. An on-line detection device for the finished product quality of Guben Yanling Pills according to claim 4, characterized in that: The upper grinding mechanism (4) comprises a sealing disk (41), a rotating shaft (42), a square driving column (43), a shifting block (44) and a grinding block (45); The sealing disk (41) is fixedly arranged at the bottom end of the inner sleeve (36); the rotating shaft (42) passes through the sealing disk (41) and is rotatably connected to the sealing disk (41) via a bearing; the square driving column (43) is fixedly arranged at the top end of the rotating shaft (42) and is slidably arranged inside the square driving groove (33) in a vertical direction; the shifting block (44) is fixedly arranged at the side of the rotating shaft (42); and the grinding block (45) is fixedly arranged at the bottom end of the rotating shaft (42).

6. The online detection device for the finished product quality of Guben Yanling Pills according to claim 5, characterized in that: The dry powder adding mechanism (5) comprises a threaded sleeve (51), a dry powder storage cylinder (52), a blocking disk (53) and an adding channel (54); The threaded sleeve (51) and the dry powder storage cylinder (52) are fixedly arranged through the top left side of the sealing plate (41) in sequence from outside to inside. The blocking plate (53) is fixedly sleeved on the outer bottom of the threaded sleeve (51). The adding channel (54) is arranged through the top left side of the blocking plate (53).

7. An on-line detection device for the finished product quality of Guben Yanling Pills according to claim 6, characterized in that: The dry powder adding mechanism (5) further includes a guide rod (55), a moving block (56), an arc-shaped arm (57), a knocking block (58) and a second spring (59); The guide rod (55) is fixedly arranged at the bottom right side of the dry powder storage cylinder (52). The moving block (56) is slidably sleeved on the outer side of the guide rod (55). The arc-shaped arm (57) is fixedly arranged on the back of the moving block (56). The knocking block (58) is fixedly arranged at the end of the knocking block (58) and is in contact with the outer wall of the dry powder storage cylinder (52). The second spring (59) is fixedly connected between the threaded sleeve (51) and the knocking block (58).

8. An on-line detection method for the finished product quality of Guben Yanling Pills, which is realized by using the above-mentioned on-line detection device for the finished product quality of Guben Yanling Pills, is characterized in that, The method specifically includes the following steps: S1. Prepare Salvia miltiorrhiza identification solution, Cistanche deserticola identification solution, Cuscuta chinensis identification solution, Ophiopogon japonicus identification solution, Panax ginseng identification solution, Schisandra chinensis identification solution, Asparagus cochinchinensis identification solution and Rehmannia glutinosa Libosch. f. hueichingensis (Chao) Hsiao & K. M. Feng identification solution. Use a capillary glass tube to pick up each identification solution and dot it on multiple silica gel G plates. After drying, put them into the chromatography solutions of the corresponding medicinal materials for plate climbing respectively. After the plate climbing is completed, take them out and dry them. Observe the developed spots under different lights and take pictures and input them into the computer as detection references; S2. Place the finished product of the to-be-detected Guben Yanning Pills inside the grinding groove (23). Add the dry powder to be added into the dry powder storage cylinder (52) through the top opening of the dry powder storage cylinder (52). Due to the blocking of the blocking plate (53), the dry powder will not directly fall out from the bottom of the dry powder storage cylinder (52). Start the driving motor (32). After the driving motor (32) starts, it drives the reciprocating screw rod (31) to rotate. When the reciprocating screw rod (31) rotates, it drives the outer sleeve (34) to descend. During the descending process of the outer sleeve (34), it drives the inner sleeve (36) to descend through the first spring (35), and drives the one-way screw rod (38) to descend through the outer plate (37); S3. When the reciprocating screw rod (31) rotates, it drives the square driving column (43) to rotate through the square driving groove (33). When the square driving column (43) rotates, it drives the dial block (44) and the grinding block (45) to rotate through the rotating shaft (42). When the inner sleeve (36) descends, it drives the sealing plate (41) to descend. During the descending process of the sealing plate (41), it drives the grinding block (45) to descend through the rotating shaft (42); S4. When the descending distance of the outer sleeve (34) reaches the first threshold, the bottom of the grinding block (45) contacts the finished product of the to-be-detected Guben Yanning Pills inside the grinding groove (23). Subsequently, as the outer sleeve (34) continues to descend, the grinding block (45) squeezes and crushes the finished product of the to-be-detected Guben Yanning Pills; S5, when the outer sleeve (34) descends to a second threshold, the bottom of the sealing disk (41) contacts the top of the grinding seat (21), and the grinding block (45) rotates continuously inside the grinding groove (23), thereby cooperating with the inner wall of the grinding groove (23) to grind the crushed Guben Yanling Pills to be tested. In addition, due to the obstruction of the grinding seat (21), the sealing disk (41) cannot continue to descend. Subsequently, as the outer sleeve (34) continues to descend, the first spring (35) is continuously compressed, and at the same time, the outer sleeve plate (37) continues to drive the one-way screw (38) to descend; S6, when the outer sleeve (34) descends a distance reaching a third threshold, the one-way screw (38) enters the inner side of the threaded sleeve (51), and as the one-way screw (38) continues to descend, the threaded sleeve (51) is driven by the one-way screw (38) to rotate continuously, and the threaded sleeve (51) drives the blocking disk (53) to rotate synchronously during the rotation process, and the blocking disk (53) drives the adding channel (54) to periodically pass under the dry powder storage barrel (52), and when the adding channel (54) is located under the dry powder storage barrel (52), the dry powder in the dry powder storage barrel (52) falls into the grinding groove (23) through the adding channel (54); S7, after the dry powder falls into the grinding groove (23), the continuously rotating rotating shaft (42) drives the grinding block (45) to grind and mix the dry powder and the finished product of the Guben Yanling Pill to be tested. At the same time, due to the rotation of the rotating shaft (42), the shifting block (44) periodically pushes the moving block (56), and the moving block (56) moves to the left outside the guide rod (55) after being pushed, and at the same time drives the knocking block (58) to compress the second spring (59) through the arc arm (57). When the shifting block (44) is moved away, the compressed second spring (59) pushes the knocking block (58), and then the knocking block (58) knocks the outer wall of the dry powder storage tube (52), so that the dry powder inside the dry powder storage tube (52) is stably accumulated at the inner bottom of the dry powder storage tube (52) to be discharged; S8, when the outer sleeve (34) descends to a fourth threshold value, the outer sleeve (34) moves to the bottom of the reciprocating thread on the outside of the reciprocating screw (31), and then as the reciprocating screw (31) continues to rotate, the outer sleeve (34) moves upward and resets. When the outer sleeve (34) moves upward to a fifth threshold value, the addition of the dry powder is completed. When the reciprocating screw (31) continues to rotate, the compressed outer sleeve (34) gradually resets. When the outer sleeve (34) moves upward to a sixth threshold value, the outer sleeve (34) reaches the initial position on the outside of the reciprocating screw (31), that is, the top of the reciprocating thread on the outside of the reciprocating screw (31). At this time, the drive motor (32) is stopped, and a mixture is formed inside the grinding tank (23); S9. Take 5 parts of the above mixture and put them into a beaker. Add 45 - 50 parts of the leaching solution thereto, and place it on a shaker for shaking and mixing. The shaking time is 30 min and the temperature is 45 °C. Filter to obtain the filter residue and filtrate a. Then add 30 - 35 parts of the leaching solution to the filter residue, and place it in a shaker for shaking. The shaking time is 20 min and the temperature is 43 °C. Filter and collect the filtrate to obtain filtrate b. Mix filtrate a and filtrate b and set aside for use; Centrifuge the above filtrate in a centrifuge. Take 30 - 40 parts of the clear supernatant and put it into a conical flask. Place the conical flask in a water bath for water bath heating. The temperature of the water bath is 100 °C and the water bath heating time is 5 h. When the water bath heating is started, simultaneously start the condensing reflux device. After the reaction is completed, take out the conical flask, quickly wrap the mouth of the bottle with a sealing film for sealing, and let it stand to room temperature for standby; Pour the solution in the above - treated conical flask into a separating funnel, and then add ethyl acetate for extraction. Use a capillary glass tube to pick up the aqueous solution and spot it on a silica gel G plate. Dry it with a hair dryer, place it under a 254 - mm ultraviolet lamp, and observe whether there are color - developing spots. If there are, continue extraction. If not, it proves that the extraction is completed. Combine all the organic phases in the extraction process, add anhydrous magnesium sulfate thereto until anhydrous magnesium sulfate exists in a powdery state in the solution, and then perform suction filtration. Collect the filtrate, rotary - evaporate the filtrate with a rotary evaporator, and collect the residue for standby; Take 0.5 part of the above residue, add anhydrous ethanol for dissolution until the residue is completely dissolved. Add an antioxidant and color - reducing agent accounting for 0.02% of the solution volume thereto, and shake and mix evenly to obtain the treatment solution of the tested Guben Yanling Pills; S10. Use a capillary glass tube to pick up the treatment solution of the tested Guben Yanling Pills and spot it on multiple silica gel G plates. After drying, place them separately in the chromatography solutions of the corresponding medicinal materials for plate development. After the plate development is completed, take them out and dry. Observe the developed spots under different lights and compare them online with the photos of the developed spots of each identification solution in the computer. If the developed spots of the treatment solution of the tested Guben Yanling Pills match the developed spots of all the above - mentioned identification solutions, it is confirmed as qualified Guben Yanling Pills.

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