Raw material treatment equipment for biological medicine manufacturing

Abstract

The invention relates to the field of raw material treatment equipment for biological medicine manufacturing, in particular to raw material treatment equipment for biological medicine manufacturing, which comprises a trough and further comprises a static grinding head, the static grinding head is umbrella-shaped, and the bottom end of the static grinding head is vertically and fixedly connected with the inner bottom surface of the trough; and the movable grinding head is connected to the top of the static grinding head in a sleeving mode, rotates relative to the static grinding head and is used for grinding the bio-based materials, and plastic bottles are hinged to the peripheral wall of the outer side of the movable grinding head in an annular array mode. According to the device, a structure for increasing the rotating inertia of the movable grinding head by filling water to improve the crushing force is provided, high-power motor driving is not needed any more, the rotating radius of the device is increased in a plastic bottle hanging and recycling mode, the moving inertia is increased by filling water, the strong crushing force is obtained, and materials are low in cost and easy to obtain; the device has a large number of hollow structures, is light in weight and low in production material requirement, and has the advantages of being low in equipment production cost, low in use cost and small in driving energy consumption.

Description

Technical Field

[0001] The invention relates to the field of biopharmaceutical manufacturing, in particular to a raw material processing device for biopharmaceutical manufacturing. Background Art

[0002] The original materials of biological drugs come from organisms and biological tissues. Some biological tissues have hard shells, which are difficult to crush. A motor with higher power is required to meet the driving requirements of the crushing equipment. Such equipment needs to be improved in terms of energy saving performance. The present invention proposes a raw material processing equipment for biological drug manufacturing that uses flywheel energy storage to increase the crushing force of the equipment, thereby reducing the power demand of the motor. Summary of the invention

[0003] In view of the problem in the above or prior art that the biological raw materials for the production of biological drugs require large crushing power and are not energy-efficient, the present invention is proposed.

[0004] Therefore, an object of the present invention is to provide a raw material processing equipment for the manufacture of biopharmaceuticals.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions: a raw material processing equipment for the manufacture of biological drugs, including a material trough, and also including a static grinding head, the static grinding head is arranged in an umbrella shape, and the bottom end of the static grinding head is vertically fixedly connected to the bottom surface of the material trough; a dynamic grinding head, the dynamic grinding head is sleeved on the top of the static grinding head, and rotates relative to the static grinding head to grind the bio-based material, and the outer peripheral wall of the dynamic grinding head is hinged with plastic bottles in an annular array, the dynamic grinding head is provided with a cavity inside and communicated with the plastic bottle, the cavity and the plastic bottle are filled with water to increase the rotational inertia of the dynamic grinding head; a funnel, the funnel is suspended at the top of the dynamic grinding head to facilitate the delivery of bio-based raw materials between the dynamic grinding head and the static grinding head, a screen is softly connected in the funnel, a cam structure is arranged between the top of the rotating shaft of the dynamic grinding head and the screen, the cam structure is used to move the screen once for each rotation of the rotating shaft to control the material discharge speed.

[0006] As a preferred solution of the raw material processing equipment for manufacturing biological drugs of the present invention, a motor is arranged on the bottom surface of the material trough, and the output shaft of the motor vertically penetrates the material trough upward and is rigidly coaxially connected to the rotating shaft of the moving grinding head.

[0007] As a preferred solution of the raw material processing equipment for manufacturing biological drugs of the present invention, the rotating shaft of the dynamic grinding head passes through the static grinding head along the axis direction of the static grinding head, and the rotating shaft of the dynamic grinding head is rotatably connected with the static grinding head.

[0008] As a preferred embodiment of the raw material processing equipment for biopharmaceutical manufacturing of the present invention, wherein: a protective mesh cover is fitted and covered on the top of the material tank, and the middle of the protective mesh cover is open, and the funnel is fixedly hung with the opening of the protective mesh cover.

[0009] As a preferred embodiment of the raw material processing equipment for biopharmaceutical manufacturing of the present invention, wherein: a rubber ring is fixedly connected to the edge of the sieve mesh in a circular shape, and a rigid collar is fixedly connected to the outer edge of the rubber ring, and the collar is fitted and squeezed onto the inner wall of the funnel.

[0010] As a preferred embodiment of the raw material processing equipment for biopharmaceutical manufacturing of the present invention, wherein: the cam structure includes a cam provided at the top of the rotating shaft, the cam is sleeved with a sleeve block, the top of the sleeve block is fixedly connected to the sieve mesh, the cam is rotatably connected with a roller, and the roller rolls along the inner wall of the sleeve block.

[0011] As a preferred embodiment of the raw material processing equipment for biopharmaceutical manufacturing of the present invention, wherein: an arc-shaped protrusion is provided on the inner arc-shaped circumferential wall of the sleeve block, and the vertical distance between the peak of the arc-shaped protrusion and the inner wall of the sleeve block is equal to the maximum distance between the cam and the edge of the roller.

[0012] As a preferred embodiment of the raw material processing equipment for biopharmaceutical manufacturing of the present invention, wherein: triangular reinforcing ribs I are provided inside both the static grinding head and the dynamic grinding head, the top opening of the dynamic grinding head is hermetically covered with a conical cover plate, and reinforcing ribs II are provided between the adjacent reinforcing ribs I on the bottom surface of the cover plate, and both ends of the reinforcing ribs II abut against the reinforcing ribs I.

[0013] As a preferred embodiment of the raw material processing equipment for biopharmaceutical manufacturing of the present invention, wherein: the inner and outer edges of the cover plate and the reinforcing ribs I inside the dynamic grinding head are fixedly connected by screws, sealing rings are pressed between the inner and outer edges of the cover plate and the dynamic grinding head, and the water injection port on the cover plate is sealed with a plug.

[0014] As a preferred embodiment of the raw material processing equipment for biopharmaceutical manufacturing of the present invention, wherein: a radial bracket is fixedly connected inside the top opening of the cover plate, and the rotating shaft is fixedly sleeved with the bracket.

[0015] The beneficial effects of the raw material processing equipment for biopharmaceutical manufacturing of the present invention: The device provides a structure that increases the rotational inertia of the dynamic grinding head by filling water to improve the crushing force, no longer requires a high-power motor for driving. The device uses the method of hanging plastic bottles to increase the rotation radius and fills water to increase the moment of inertia to obtain the crushing force, and it is adjustable. The equipment materials are cheap and easily available; the device has a large number of cavities and hollow structures, has a relatively light weight itself, and requires less production materials. The present invention has the advantages of low equipment production cost, low use cost, and low driving energy consumption. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0017] Figure 1 Schematic diagram of the structure of raw material processing equipment for biopharmaceutical manufacturing.

[0018] Figure 2 for Figure 1 Schematic diagram of the structure after cutting away the protective mesh cover.

[0019] Figure 3 for Figure 2 Exploded view of the assembly structure between the central grinding head, cover plate and funnel.

[0020] Figure 4 for Figure 2 Cross-sectional view of the assembly structure of the dynamic grinding head, static grinding head and funnel.

[0021] Figure 5 for Figure 4 A magnified view of the structure at center.

[0022] Figure 6 for Figure 5 Perspective, and Figure 6 for Figure 5 Structural breakdown diagram.

[0023] Figure 7 for Figure 4 Structural anatomy at point B in the middle.

[0024] In the figure: 100, material trough; 101, protective mesh cover; 102, static grinding head; 103, dynamic grinding head; 104, funnel; 105, screen; 106, rubber ring; 107, collar; 108, cam; 109, roller; 110, sleeve block; 111, arc-shaped protrusion; 112, reinforcing rib one; 113, reinforcing rib two; 114, sealing ring; 115, bracket; 116, motor; 117, rotating shaft; 118, plug; 119, buckle; 120, cover plate; 200, plastic bottle. DETAILED DESCRIPTION

[0025] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the accompanying drawings.

[0026] Example, see Figures 1 to 7This embodiment provides a raw material processing device for manufacturing biological drugs, referring to Figure 2 and Figure 4 As shown, it includes a trough 100, and also includes a static grinding head 102, the static grinding head 102 is arranged in an umbrella shape, and the bottom end of the static grinding head 102 is vertically fixedly connected to the inner bottom surface of the trough 100; a dynamic grinding head 103, the dynamic grinding head 103 is sleeved on the top of the static grinding head 102, and rotates relative to the static grinding head 102 to grind the bio-based material, and the outer peripheral wall of the dynamic grinding head 103 is hinged with a plastic bottle 200 in a circular array, and a cavity is provided inside the dynamic grinding head 103, and the cavity is connected to the plastic bottle 200, and the cavity and the plastic The bottle 200 is filled with water to increase the weight, thereby increasing the rotational inertia of the moving grinding head 103; the funnel 104 is suspended at the top of the moving grinding head 103 to facilitate the delivery of bio-based raw materials between the moving grinding head 103 and the static grinding head 102, and a screen 105 is softly connected in the funnel 104. A cam 108 structure is provided between the top of the rotating shaft 117 of the moving grinding head 103 and the screen 105. The cam 108 structure is used to move the screen 105 once every time the rotating shaft 117 rotates one circle, so as to control the material discharge speed.

[0027] like Figure 2 and Figure 4 As shown, a motor 116 is provided on the bottom surface of the material trough 100, and the output shaft of the motor 116 vertically penetrates the material trough 100 upward, and is rigidly coaxially connected to the rotating shaft 117 of the moving grinding head 103, the rotating shaft 117 of the moving grinding head 103 penetrates the static grinding head 102 along the axial direction of the static grinding head 102, and the rotating shaft 117 of the moving grinding head 103 is rotatably connected to the static grinding head 102, and a radial bracket 115 is fixedly connected in the top opening of the cover plate 120, and the rotating shaft 117 is fixedly sleeved with the bracket 115.

[0028] like Figure 1 and Figure 2 As shown, the top of the trough 100 is matched and covered with a protective mesh cover 101, and the middle of the protective mesh cover 101 is open, and the funnel 104 is fixedly hung with the opening of the protective mesh cover 101, as shown in FIG. Figure 4 As shown, the edge of the screen 105 is annular and fixedly connected with a rubber ring 106, and the outer edge of the rubber ring 106 is fixedly connected with a hard ring 107, the ring 107 is pressed and sleeved with the inner wall of the funnel 104, and the cam 108 structure includes a cam 108 arranged at the top of the rotating shaft 117, the cam 108 is sleeved with a sleeve block 110, the top of the sleeve block 110 is fixedly connected with the screen 105, the cam 108 is rotatably connected with a roller 109, and the roller 109 rolls against the inner wall of the sleeve block 110.

[0029] like Figure 7 As shown, the inner arc circumferential wall of the sleeve block 110 is provided with an arc-shaped protrusion 111 , and the vertical distance between the peak of the arc-shaped protrusion 111 and the inner wall of the sleeve block 110 is equal to the maximum distance between the cam 108 and the edge of the roller 109 .

[0030] As Figure 3 and Figure 4 shown, triangular stiffeners 112 are provided inside both the static grinding head 102 and the dynamic grinding head 103. The top opening of the dynamic grinding head 103 is hermetically covered with a conical cover plate 120. And between the bottom surface of the cover plate 120 and adjacent stiffeners 112, second stiffeners 113 are provided. The two ends of the second stiffeners 113 abut against the first stiffeners 112. The cover plate 120 is fixedly connected to the first stiffeners 112 by screws. And sealing rings 114 are pressed between the inner and outer edges of the cover plate 120 and the dynamic grinding head 103. The water injection port on the cover plate 120 is sealed with a plug 118.

[0031] The present invention provides a raw material processing device for the manufacture of biological drugs, in particular a structure that increases the rotational inertia of the dynamic grinding head 103 by filling it with water to improve the crushing force. As Figure 3 shown, the inside of the dynamic grinding head 103 is hollow, forming a sealed cavity with the cover plate 120, and plastic bottles 200 are hung around it. By filling the sealed cavity and the plastic bottles 200 with water, the weight and the movement radius of the dynamic grinding head 103 are significantly increased, greatly increasing the rotational inertia of the dynamic grinding head 103. Thus, the dynamic grinding head 103 can be regarded as a flywheel for energy storage. After being driven by a low-power motor 116 to increase the speed, a powerful rotational inertia is used to cooperate with the static grinding head 102 to extrude and rub the biological substrate to achieve crushing. The crushed biological substrate falls into the material trough 100.

[0032] According to the mechanical formula F = ma, the dynamic grinding head 103 is rotationally supported by bearings and has a small rotational resistance. A motor 116 with a low power can also overcome this rotational resistance to drive the dynamic grinding head 103 to rotate. Whether the power of the motor 116 is large or small, the main difference lies in the magnitude of the acceleration when driving the dynamic grinding head 103 to rotate. When the weight of the rotating object increases while the output power of the motor 116 is small, the acceleration of the dynamic grinding head 103 during rotation is small. After a period of acceleration, the dynamic grinding head 103 can still obtain a relatively high rotational speed. And when the dynamic grinding head 103 obtains a high rotational speed, the stored kinetic energy is used to obtain a good crushing effect.

[0033] This device uses the method of hanging plastic bottles 200 to increase the rotation radius and filling water to increase the mass. Water is also cheap and easily available; this device has a large number of cavities and hollow structures, has a relatively light weight itself, and requires less production materials; therefore, it is considered that the present invention has the advantages of low equipment production cost, low use cost, and low driving energy consumption, and further facilitates the handling of the equipment.

[0034] To achieve the above target functions, the present invention also involves the following technical details: First, the device allows continuous feeding and crushing, and briefly pauses the feeding at a certain frequency to help the moving grinding head 103 that loses kinetic energy during the crushing of the biological substrate to resume its rotation speed. This technical problem is solved by the sieve 105 and the cam 108 structure in the present invention; First of all, feeding and discharging are two different stages. Feeding refers to manually putting a large amount of biological substrate into the funnel 104, and discharging refers to the biological substrate entering the crushing working area of the moving grinding head 103 and the static grinding head 102. Putting more materials at one time can facilitate the operation of workers. However, when discharging, it is necessary to control the amount and speed of discharging to avoid equipment jamming due to excessive and too fast discharging; The device blocks the material pile in the funnel 104 through the sieve 105. The biological substrate particles in the material pile are stacked and squeezed with each other to form a stable piled material structure and will not easily pass through the sieve 105. Refer to Figure 7 , when the rotating shaft 117 rotates one circle, when the roller 109 on the cam 108 passes through the convex part on the inner wall of the sleeve block 110, it will push the sleeve block 110 and the sieve 105 once. The sieve 105 realizes a jitter through the rubber ring 106 at its edge. The jittering sieve 105 will destroy the piled material stability of some biological substrates at the bottom of the material pile, so that a small amount of biological substrates pass through the sieve 105 and fall for crushing. When the cam 108 leaves the convex part on the inner wall of the sleeve block 110, the feeding is reduced or stopped. The reduced load of the motor 116 enables the rotation speed of the moving grinding head 103 to increase again. During the repetition of the above process, the rotation speed of the rotating shaft 117 should not be too high. Otherwise, when the feeding frequency reaches a certain level, if the intermittent time is too short, it can be regarded as continuous and large-scale feeding, and the continuous high load of the motor 116 may cause the moving grinding head 103 to continuously decelerate and lose sufficient crushing force. Therefore, the motor 116 should also use a model with a built-in speed reducer; Second, the device uses a plastic bottle 200 filled with water to extend the rotation radius of the moving grinding head 103, which has the advantage of environmental protection. Here, two technical problems are involved. One is that even if plastic bottles 200 of the same specification are used, it is necessary to ensure that all the air in each plastic bottle 200 is exhausted so that the water volume in each plastic bottle 200 is equal to ensure the dynamic balance during the rotation of the moving grinding head 103. Therefore, the exhaust problem needs to be considered. By placing the plastic bottle 200 vertically and squeezing it, as Figure 5 shown, the gas in it is squeezed into the moving grinding head 103 through the quick connector and the hose and floats out. After the moving grinding head 103 rotates, the centrifugal force will cause the plastic bottle 200 to lift itself; the other is that the general bottle mouth thread design of the plastic bottle 200 is not itself used for a high-strength use environment, so its thread connection strength cannot withstand the strong centrifugal force generated during the rotation of the moving grinding head 103, as Figure 5 and Figure 6As shown in the figure, the device uses a metal snap 119, which is buckled on the edge of the mouth of the plastic bottle 200, so that the mouth of the plastic bottle 200 presses tightly against the sealing gasket, realizing the sealing and fixing of the plastic bottle 200.

[0035] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the spirit and scope of the technical solutions of the present invention, and they should all be covered within the scope of the claims of the present invention.

Claims

1. A raw material processing device for biopharmaceutical manufacturing, including a material tank (100), characterized in that: Also includes, A static grinding head (102), the static grinding head (102) being arranged in an umbrella shape, and the bottom end of the static grinding head (102) being vertically fixedly connected to the inner bottom surface of the material trough (100); A dynamic grinding head (103), the dynamic grinding head (103) being sleeved on the top of the static grinding head (102) and rotating relative to the static grinding head (102) for grinding bio-based materials, and the outer peripheral wall of the dynamic grinding head (103) is hingedly connected to a plastic bottle (200) in a circular array, the dynamic grinding head (103) is provided with a cavity inside and is connected to the plastic bottle (200), and the cavity and the plastic bottle (200) are filled with water for increasing the rotational inertia of the dynamic grinding head (103); A funnel (104) is suspended at the top of the moving grinding head (103) and is used to facilitate the feeding of bio-based raw materials between the moving grinding head (103) and the static grinding head (102). A screen (105) is flexibly connected inside the funnel (104). A cam (108) structure is provided between the top of the rotating shaft (117) of the moving grinding head (103) and the screen (105). The cam (108) structure is used to move the screen (105) once every time the rotating shaft (117) rotates one circle, so as to control the feeding speed.

2. The raw material processing equipment for biopharmaceutical manufacturing according to claim 1, characterized in that: A motor (116) is disposed on the bottom surface of the material trough (100), and an output shaft of the motor (116) vertically penetrates the material trough (100) upwards and is rigidly coaxially connected to a rotating shaft (117) of the movable grinding head (103).

3. The raw material processing equipment for biopharmaceutical manufacturing according to claim 2, characterized in that: The rotating shaft (117) of the dynamic grinding head (103) penetrates the static grinding head (102) along the axis direction of the static grinding head (102), and the rotating shaft (117) of the dynamic grinding head (103) is rotatably connected to the static grinding head (102).

4. The raw material processing equipment for biopharmaceutical manufacturing according to claim 1, characterized in that: The top of the material trough (100) is matched and covered with a protective mesh cover (101), and the middle of the protective mesh cover (101) is open, and the funnel (104) is fixedly hung with the opening of the protective mesh cover (101).

5. The raw material processing equipment for biopharmaceutical manufacturing according to claim 1, wherein: The edge of the screen (105) is annularly fixedly connected to a rubber ring (106), and the outer edge of the rubber ring (106) is fixedly connected to a hard ring (107), and the ring (107) is pressed and sleeved with the inner wall of the funnel (104).

6. The raw material processing equipment for biopharmaceutical manufacturing according to claim 1, characterized in that: The cam (108) structure comprises a cam (108) arranged at the top end of a rotating shaft (117); the cam (108) is sleeved with a sleeve block (110); the top end of the sleeve block (110) is fixedly connected to the screen (105); the cam (108) is rotatably connected with a roller (109), and the roller (109) rolls in contact with the inner wall of the sleeve block (110).

7. The raw material processing equipment for biopharmaceutical manufacturing according to claim 6, wherein: The inner arc circumferential wall of the sleeve block (110) is provided with an arc-shaped protrusion (111), and the vertical distance between the peak of the arc-shaped protrusion (111) and the inner wall of the sleeve block (110) is equal to the maximum distance between the cam (108) and the edge of the roller (109).

8. The raw material processing equipment for biopharmaceutical manufacturing according to claim 1, characterized in that: The static grinding head (102) and the dynamic grinding head (103) are both provided with a triangular reinforcing rib I (112). The top opening of the dynamic grinding head (103) is hermetically covered with a conical cover plate (120). And a reinforcing rib II (113) is arranged between the adjacent reinforcing ribs I (112) on the bottom surface of the cover plate (120), and both ends of the reinforcing rib II (113) abut against the reinforcing rib I (112).

9. The raw material processing equipment for biopharmaceutical manufacturing according to claim 8, wherein: The inner and outer edges of the cover plate (120) and the reinforcing rib I (112) inside the dynamic grinding head (103) are fixedly connected by screws. And sealing rings (114) are pressed between the inner and outer edges of the cover plate (120) and the dynamic grinding head (103). The water injection port on the cover plate is sealed with a plug (118).

10. The raw material processing equipment for biopharmaceutical manufacturing according to claim 9, characterized in that: A radial bracket (115) is fixedly connected inside the top opening of the cover plate (120), and the rotating shaft (117) is fixedly sleeved with the bracket (115).

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