Hydrogel patch delivery equipment and adhesion method

Abstract

The invention provides hydrogel patch delivery equipment and an adhesion method. The hydrogel patch delivery equipment comprises a shell, an adhesion triggering assembly, an image acquisition device, a magnetic device and a hydrogel patch, wherein the image acquisition device and the magnetic device are arranged in the shell; the hydrogel patch is arranged on the outer side surface of the shell; the hydrogel patch comprises cations; the attachment trigger assembly comprises a boost control module, and an anode strip and a cathode strip which are electrically connected with the boost control module, and the anode strip is in contact with the hydrogel patch; the boost control module is configured to boost the voltage at the two ends of the hydrogel patch to a threshold voltage when the cathode plate and the hydrogel patch are in contact with the inner wall of the alimentary canal, so that the hydrogel patch is adhered to the inner wall of the alimentary canal. The problems that an existing mode for treating digestive tract diseases through hydrogel brings pain to a patient, the treatment area is limited, the adhesion process of the hydrogel is uncontrollable, and the treatment effect is easily affected are solved.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular to a hydrogel patch delivery device and an adhesion method. Background Art

[0002] As an emerging polymer material, gel patches play a key role in the treatment of gastrointestinal diseases due to their good biocompatibility, degradability and efficient adhesion. They have application prospects in mucosal hemostasis, covering ulcer areas to promote wound healing, carrying drugs for continuous treatment of local diseased areas, and combining with flexible circuits for biological signal monitoring.

[0003] Currently, the common method of using hydrogel patches to treat gastrointestinal diseases is to deliver the hydrogel from outside the body to the local diseased area in the body through a medical electronic endoscope, and use chemical bonding to make the hydrogel adhere to the gastrointestinal mucosa. This invasive treatment method not only causes pain to the patient, but also has a limited length of entry into the human body, resulting in a restricted treatment area. In addition, the adhesion of the hydrogel to the gastrointestinal mucosa depends on chemical reactions, making the adhesion process uncontrollable and easily affecting the treatment effect. Summary of the Invention

[0004] The embodiments of the present application provide a hydrogel patch delivery device and adhesion method, which solves the problem that the existing method of using hydrogel to treat digestive tract diseases not only causes pain to patients, but also limits the treatment area, and the hydrogel adhesion process is uncontrollable, which easily affects the treatment effect.

[0005] The present invention is implemented as follows: a hydrogel patch delivery device includes a shell, an image acquisition device, a magnetic device, a hydrogel patch and an attachment trigger component; the image acquisition device is arranged in the shell, and the image acquisition device is used to acquire images inside the digestive tract; the magnetic device is arranged in the shell; the hydrogel patch is arranged on the outer side of the shell, and the hydrogel patch includes cations; the attachment trigger component includes a boost control module and an anode plate arranged in the shell, and a cathode plate arranged on the outer side of the shell, the anode plate contacts the hydrogel patch, and the anode plate and the cathode plate are both electrically connected to the boost control module; the boost control module is configured to increase the voltage across the hydrogel patch to a threshold voltage when the cathode plate and the hydrogel patch respectively contact the inner wall of the digestive tract, so that the hydrogel patch adheres to the inner wall of the digestive tract, wherein the threshold voltage is greater than the turn-on voltage of the hydrogel patch to produce an electroadhesion effect.

[0006] In one embodiment, the attachment trigger assembly further includes a first circuit board, a second circuit board, and a wireless transmission device disposed within the housing;

[0007] The boost control module includes a control circuit and a PWM signal generating circuit provided on the first circuit board, and a boost circuit provided on the second circuit board;

[0008] The control circuit is electrically connected to the image acquisition device, the PWM signal generating circuit and the wireless transmission device respectively, and the boost circuit is electrically connected to the PWM signal generating circuit, the anode plate and the cathode plate respectively.

[0009] In one embodiment, the attachment trigger component further includes a battery, and the battery is electrically connected to the control circuit.

[0010] In one embodiment, the wireless transmission device is a radio frequency wireless transmission antenna, and the radio frequency wireless transmission antenna is wound around the outer side of the battery.

[0011] In one embodiment, the housing includes a cylindrical shell body and a first cover and a second cover respectively covering two ends of the shell body;

[0012] The first cover has a transparent window, and the light-collecting surface of the image acquisition device is opposite to the transparent window;

[0013] Along the axial direction of the shell body, the image acquisition device, the battery, the first circuit board, the magnetic device and the second circuit board are arranged in sequence.

[0014] In one embodiment, the shell body is provided with a mounting opening that passes through the shell body, and a mounting plate is provided at the position where the mounting opening is provided on the inner side of the shell body, and the mounting opening and the mounting plate enclose a receiving space;

[0015] The anode sheet is arranged on the mounting plate;

[0016] The hydrogel patch is located in the accommodating space, and a pressing block is provided on the outer side of the shell body, and the pressing block abuts against the hydrogel patch.

[0017] In one embodiment, the shell body is cylindrical, and the mounting plate is an arc-shaped plate;

[0018] The mounting plate is provided with an embedding opening which passes through the mounting plate, and the anode sheet is embedded in the embedding opening;

[0019] The surface of the anode sheet close to the hydrogel patch and the surface of the mounting plate close to the hydrogel patch are located on the same cylindrical surface, and the anode sheet is attached to the hydrogel patch.

[0020] In one embodiment, the shell body is cylindrical, and a groove is provided on the outer side of the shell body, and the groove is arranged around the mounting opening;

[0021] The cathode plate is arranged in the groove, and a surface of the cathode plate away from the bottom of the groove and an outer surface of the shell body are located on the same cylindrical surface.

[0022] In one embodiment, a mounting seat is provided in the shell, the magnetic device is provided on the mounting seat, and a gap exists between a side surface of the magnetic device away from the mounting seat and an inner side surface of the shell.

[0023] The present application also provides a hydrogel patch adhesion method, which is applied to a hydrogel patch delivery device as described in any of the above embodiments, comprising:

[0024] Acquire images of the digestive tract;

[0025] attaching the hydrogel patch and the cathode patch to the target attachment position;

[0026] increasing the voltage across the hydrogel patch to a threshold voltage so that the hydrogel patch adheres to the inner wall of the digestive tract;

[0027] The shell is separated from the hydrogel patch.

[0028] The hydrogel patch delivery device and adhesion method provided by the present application have the following advantages: compared with the prior art, the present application provides an image acquisition device and a magnetic device within the housing, and a hydrogel patch is provided on the outer side of the housing. The external magnetic field can control the magnetic device to perform multi-degree-of-freedom movement, so that the entire hydrogel patch delivery device can move to any position within the digestive tract. During the movement, the image acquisition device is used to capture images of the digestive tract for diagnosis by the doctor, and the hydrogel patch is then adhered to the lesion area on the inner wall of the digestive tract for treatment. This not only provides more functions but also enables diagnosis and treatment of the entire digestive tract, with a wider range of diagnosis and treatment. During the treatment process, the hydrogel patch will move synchronously with the magnetic device, without causing pain to the patient. In addition, the hydrogel patch of the present application carries cations, so the provision of a boost control module can control the voltage across the hydrogel patch to increase, so that the hydrogel patch carrying cations is driven by the voltage to cross-link with the biological mucosal tissue exhibiting anionic electrical properties, causing the hydrogel patch to adhere to the inner wall of the digestive tract. This electrical adhesion method can make the adhesion effect more controllable and the adhesion effect better. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 is an exploded view of a hydrogel patch delivery device provided in an embodiment of the present application;

[0030] Figure 2 Schematic diagram of the structure of the hydrogel patch delivery device provided in the embodiment of the present application;

[0031] Figure 3 This is a schematic structural diagram of the hydrogel patch of the hydrogel patch delivery device provided in an embodiment of the present application after being separated from the housing;

[0032] Figure 4 is a schematic diagram of the internal circuit of the hydrogel patch delivery device provided in an embodiment of the present application;

[0033] Figure 5 is a circuit schematic diagram of a boost circuit of a hydrogel patch delivery device provided in an embodiment of the present application;

[0034] Figure 6 This is a schematic diagram of the installation of the magnetic device of the hydrogel patch delivery device provided in an embodiment of the present application;

[0035] Figure 7 Flowchart of the hydrogel patch adhesion method provided in the embodiment of the present application.

[0036] Reference numerals: 1, housing; 10, mounting opening; 11, housing body; 12, first cover; 13, second cover; 14, mounting plate; 140, embedding opening; 111, groove;

[0037] 2. Image acquisition device; 3. Magnetic device; 4. Hydrogel patch;

[0038] 51. Boost control module; 511. Control circuit; 512. PWM signal generating circuit; 513. Boost circuit; 52. Anode plate; 53. Cathode plate; 54. First circuit board; 55. Second circuit board; 56. Wireless transmission device; 57. Battery; 6. Press block; 7. Mounting base. DETAILED DESCRIPTION

[0039] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0040] It should be noted that when an element is referred to as being “fixed on” or “disposed on” another element, it may be directly on the other element or indirectly on the other element. When an element is referred to as being “connected to” another element, it may be directly connected to the other element or indirectly connected to the other element.

[0041] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this application.

[0042] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. Throughout the description of this application, "plurality" means two or more, unless otherwise specifically defined.

[0043] It should also be noted that, in the embodiments of the present application, the same figure mark represents the same component or the same part. For the same parts in the embodiments of the present application, the figure may only mark one of the parts or components as an example. It should be understood that the figure mark also applies to other identical parts or components.

[0044] The embodiments of the present application provide a hydrogel patch delivery device and adhesion method, which solves the problem that the existing method of using hydrogel to treat digestive tract diseases not only causes pain to patients, but also limits the treatment area, and the hydrogel adhesion process is uncontrollable, which easily affects the treatment effect.

[0045] refer to Figure 1 and Figure 2 The hydrogel patch delivery device provided in an embodiment of the present application includes a shell 1, an image acquisition device 2, a magnetic device 3, a hydrogel patch 4 and an attachment trigger component; the image acquisition device 2 is arranged in the shell 1, and the image acquisition device 2 is used to acquire images in the digestive tract; the magnetic device 3 is arranged in the shell 1; the hydrogel patch 4 is arranged on the outer side of the shell 1, and the hydrogel patch 4 includes cations; the attachment trigger component includes a boost control module 51 and an anode plate 52 arranged in the shell 1, and a cathode plate 53 arranged on the outer side of the shell 1, the anode plate 52 is in contact with the hydrogel patch 4, and the anode plate 52 and the cathode plate 53 are both electrically connected to the boost control module 51; the boost control module 51 is configured to increase the voltage across the hydrogel patch to a threshold voltage when the cathode plate 53 and the hydrogel patch 4 are respectively in contact with the inner wall of the digestive tract, so that the hydrogel patch 4 adheres to the inner wall of the digestive tract.

[0046] The threshold voltage is greater than the turn-on voltage of the hydrogel patch 4 at which the electroadhesion effect occurs. The turn-on voltage of the hydrogel patch 4 at which the electroadhesion effect occurs may be 10V.

[0047] The hydrogel patch delivery device of the embodiment of the present application can be regarded as a capsule endoscope with patch therapy function. Capsule endoscope is an emerging medical device specially used for the inspection and diagnosis of the digestive tract. The capsule endoscope places the camera module, wireless transmission module and power module in a capsule of a size that can be swallowed from the mouth, so that the capsule endoscope can perform a comprehensive inspection of the patient's digestive tract. The capsule endoscope provides a non-invasive, convenient and comfortable inspection method, which reduces the discomfort and risks caused by traditional inspections to a certain extent. The capsule endoscope can take high-quality images while passing through the digestive tract and transmit them to an external receiving device through a wireless transmission module, allowing doctors to comprehensively inspect the entire digestive tract including the esophagus, stomach, small intestine and large intestine, especially the small intestine part that is difficult to reach with traditional endoscopes.

[0048] Existing capsule endoscopes primarily use visual transmission for photo examinations, allowing doctors to diagnose diseases based on the captured images. These devices have relatively limited functionality and are unable to directly reach the target location for treatment after the diagnosis is complete. The hydrogel patch delivery device of the present invention, however, can capture images of the digestive tract using the image acquisition device 2 and, after the doctor's diagnosis, can move to the target location to attach the hydrogel patch 4 to the lesion area on the inner wall of the digestive tract to complete treatment. This means that the hydrogel patch delivery device of the present invention has both diagnostic and therapeutic functions, resulting in richer functionality and better results.

[0049] It can be understood that the hydrogel patch delivery device of the embodiment of the present application can be swallowed by the patient into the body when in use. Compared with the prior art method of using a medical electronic endoscope to deliver the hydrogel from the outside of the body to the local diseased area in the body, the whole process will cause pain to the patient. The way the hydrogel patch delivery device of the embodiment of the present application enters the body, and the process of the hydrogel patch delivery device moving in the body to complete diagnosis and treatment will not cause pain to the patient.

[0050] Specifically, the movement of the hydrogel patch delivery device in the digestive tract is controlled by magnetic force. A magnetic device 3 is provided in the housing 1. The magnetic device 3 can be controlled to perform multi-degree-of-freedom movement through changes in the external magnetic field, so that the entire hydrogel patch delivery device will perform multi-degree-of-freedom movement, so that it can reach any position in the digestive tract for diagnosis and treatment, greatly expanding the scope of treatment. Among them, multi-degree-of-freedom movement refers to an object or system having multiple independent modes of motion or directions in space. The "degree of freedom" (DOF) here refers to the number of independent variables (such as position, angle, etc.) required to describe the motion state of an object. Simply put, multi-degree-of-freedom movement means that an object can move or rotate independently in multiple directions, thereby completing more flexible and complex movements. That is, the hydrogel patch delivery device of the embodiment of the present application can move or rotate independently in multiple directions in the digestive tract.

[0051] For example, the magnetic device 3 can be a permanent magnet, which refers to a magnet that can retain a high remanence for a long time in an open circuit state. Such as natural magnets (magnetite) and artificial magnets (aluminum nickel cobalt alloy). Permanent magnets are also called hard magnets, which are not easy to lose magnetism or be magnetized. Using a permanent magnet as the magnetic device 3 and arranged in the shell 1 can make the hydrogel patch delivery device easily controlled by the external magnetic field in the digestive tract and move freely, and it is not easy to lose magnetism and cause the hydrogel patch delivery device to be uncontrolled and unable to reach the target position for diagnosis and treatment.

[0052] It should be noted that an image acquisition device 2 is set in the shell 1, and a transparent window can be set on the shell 1. The transparent window is made of transparent material, which allows light to pass through. The lighting surface of the image acquisition device 2 is set to be opposite to the transparent window, so that the image acquisition device 2 can collect light through the transparent window, and then can take pictures of the patient's digestive tract.

[0053] Furthermore, in order to make the captured image clear and facilitate observation by doctors for disease diagnosis, a lighting device can be set in the shell 1, and the light-emitting surface of the lighting device is opposite to the transparent shell wall, so that the light emitted by the lighting device can be emitted through the transparent shell wall, thereby providing lighting for the shooting environment of the image acquisition device 2.

[0054] A hydrogel patch 4 is provided on the shell 1 of the embodiment of the present application. As an emerging polymer material, the hydrogel patch 4 has good biocompatibility, degradability and high-efficiency adhesion, which plays a key role in the treatment of gastrointestinal diseases. It has application prospects in the fields of mucosal hemostasis, covering ulcer areas to promote wound healing, continuous treatment of local diseased areas after loading drugs, and combination with flexible circuits for biological signal monitoring.

[0055] The hydrogel patch 4 in the embodiment of the present application can be prepared in the following manner: 0.2g of synthetic lithium magnesium silicate is added to 20ml of pure water and mixed evenly to increase the toughness of the hydrogel, and then hydrochloric acid is added to adjust the pH value of the mixed solution to 5, and then 810μl of cation (methacryloyloxyethyl trimethyl ammonium chloride), 1.4g of acrylamide monomer, 0.03g of methylene bisacrylamide, 0.04g of ammonium persulfate and 30μl of tetramethylethylenediamine are added, and finally the mixed solution is allowed to stand at room temperature for 3 hours to prepare a hydrogel that is milky white and has a certain toughness. The obtained hydrogel is cut and processed to obtain a hydrogel patch 4 that can be arranged in the mounting opening 10.

[0056] The hydrogel patch 4 prepared according to the above method includes cations. The housing 1 of the embodiment of the present application is also provided with an anode plate 52 and a boost control module 51. The outer side of the housing 1 is provided with a cathode plate 53. When the hydrogel patch delivery device of the embodiment of the present application moves to the target position, the hydrogel patch 4 is directed toward the lesion area. By controlling the size of the external magnetic field, the hydrogel patch 4 and the cathode plate 53 can be made to adhere to the inner wall of the digestive tract. The boost control module 51 increases the voltage at both ends of the hydrogel patch 4. The hydrogel patch 4 carrying cations will produce cross-links with the biological mucosal tissue that presents anionic electrical properties under the drive of the voltage, thereby achieving a controllable adhesion effect. Compared with the chemical reaction adhesion method in the prior art, this electrical adhesion method has a more controllable adhesion effect, thereby achieving a better adhesion effect.

[0057] In the embodiment of the present application, a magnetic device 3 is set in the shell 1, and the external magnetic field is used to control the magnetic device 3 to perform multi-degree-of-freedom movement in the digestive tract, so that the hydrogel patch delivery device can perform multi-degree-of-freedom movement in the digestive tract and reach any position in the digestive tract. During the movement, the image acquisition device 2 is used to capture images of the digestive tract for the doctor to view and diagnose. When the disease is diagnosed, the hydrogel patch 4 is directed toward the lesion area on the inner wall of the digestive tract, and then the external magnetic field is used to control the hydrogel patch delivery device to move toward the inner wall of the digestive tract, so that the hydrogel patch 4 The cathode sheet 53 is in close contact with the inner wall of the digestive tract. At this time, the boost control module 51 increases the voltage. Since the hydrogel patch 4 includes cations, the hydrogel patch 4 carrying cations will be cross-linked with the biological mucosal tissue showing anionic electrical properties under the drive of voltage, thereby achieving a controllable adhesion effect, that is, the hydrogel patch 4 will adhere to the inner wall of the digestive tract. Then, the external magnetic field is used to control the hydrogel patch delivery device away from the inner wall of the digestive tract. At this time, the hydrogel patch 4 will separate from the shell 1 and adhere to the inner wall of the digestive tract, completing the treatment of the lesion area on the inner wall of the digestive tract. Figure 3The figure shows a schematic diagram of the hydrogel patch delivery device with the hydrogel patch detached from its housing. This allows the device to be moved to any location within the digestive tract to inspect and diagnose the lining, and also to treat affected areas. This not only expands the diagnostic scope but also provides greater functionality and ease of use for patients. The hydrogel patch 4 adheres to the digestive tract lining using electrical adhesion, making the adhesion more controllable and effective.

[0058] In some embodiments, reference Figure 1 and Figure 4 The attached trigger component also includes a first circuit board 54, a second circuit board 55 and a wireless transmission device 56 arranged in the shell 1; the boost control module 51 includes a control circuit 511 and a PWM signal generating circuit 512 arranged on the first circuit board 54, and a boost circuit 513 arranged on the second circuit board 55; the control circuit 511 is electrically connected to the image acquisition device 2, the PWM signal generating circuit 512 and the wireless transmission device 56, respectively, and the boost circuit 513 is electrically connected to the PWM signal generating circuit 512, the anode plate 52 and the cathode plate 53, respectively.

[0059] Among them, the wireless transmission device 56 is used to wirelessly transmit or receive information, such as wirelessly transmitting the image information captured by the image acquisition device 2 to a receiving device outside the body, or wirelessly receiving a trigger signal sent by an external signal sending device, so that the boost control module 51 responds to the trigger signal and increases the voltage across the hydrogel patch 4.

[0060] Through the above settings, the working principle of the hydrogel patch 4 attached to the inner wall of the digestive tract is as follows: when the hydrogel patch delivery device moves in the digestive tract, the image acquisition device 2 will take an image of the inner wall of the digestive tract and transmit it to the control circuit 511, and the control circuit 511 will transmit the image information to the wireless transmission device 56, so that the wireless transmission device 56 transmits the image information to the receiving device outside the body, so that the doctor can diagnose the inner wall of the digestive tract by observing the image; if it is diagnosed that the inner wall of the digestive tract has a lesion area, then a trigger signal can be sent to the wireless transmission device through the signal sending device outside the body, and the wireless transmission device transmits the trigger signal to the control circuit 511. Circuit 511, the control circuit 511 will control the PWM signal generating circuit 512 to output a PWM signal with an amplitude greater than 2V, and input the PWM signal into the boost circuit 513. At this time, the boost circuit 513 will increase the voltage to a voltage greater than the start voltage of the hydrogel patch 4 for the electric adhesion effect. Since the positive pole of the boost circuit 513 is electrically connected to the anode plate 52, and the negative pole is electrically connected to the cathode plate 53, the control circuit 511 continuously powers on the boost circuit 513 for a preset period of time, which is equivalent to continuously powering on the hydrogel patch 4 and the inner wall of the digestive tract for a preset period of time. At this time, the hydrogel patch 4 will be tightly adhered to the inner wall of the digestive tract, that is, the mucosa in the digestive tract.

[0061] For example, after the control circuit 511 receives the trigger signal, it controls the PWM signal generating circuit 512 to output a PWM signal with an amplitude greater than 2V (for example, 2.5V), and inputs the PWM signal into the boost circuit 513. At this time, the boost circuit 513 will increase the voltage to a voltage greater than the start-up voltage for the hydrogel patch 4 to have an electric adhesion effect. The start-up voltage for the hydrogel patch 4 to have an electric adhesion effect can be 10V, and the boost circuit 513 can increase the voltage to 12.6V.

[0062] The control circuit 511 continuously powers on the boost circuit 513 for a preset time. The preset time here can be any time. Of course, the longer the power-on time, the tighter the hydrogel patch 4 adheres to the inner wall of the digestive tract. However, the longer the time is, the better. When the adhesion between the hydrogel patch 4 and the inner wall of the digestive tract reaches a certain level, even if the power-on time is increased, the adhesion between the hydrogel patch 4 and the inner wall of the digestive tract will not be greatly improved. Therefore, it is necessary to set a suitable power-on time. In the embodiment of the present application, the preset time is set to 60s-90s. Preferably, it can be set to 60s, so that the adhesion effect between the hydrogel patch 4 and the inner wall of the digestive tract can be better.

[0063] It should be noted that the boost control module 51 and the wireless transmission device 56 in the embodiment of the present application cooperate with each other to achieve precise treatment of the lesion area, and adopt the voltage-driven electrical adhesion principle to make the hydrogel patch 4 carrying cations adhere tightly to the inner wall of the digestive tract. Compared with the prior art that relies on chemical reactions to complete the adhesion of the hydrogel patch 4, resulting in uncontrollable adhesion effect, in the embodiment of the present application, the boost circuit 513 is controlled by a PWM signal to output a high voltage for the electrical adhesion of the hydrogel patch 4, which greatly improves the controllability of the adhesion effect.

[0064] It is understandable that the main function of the boost circuit 513 in the embodiment of the present application is to increase the voltage so that the hydrogel patch 4 carrying cations can be cross-linked with the biological mucosal tissue exhibiting anionic electrical properties under the drive of voltage, thereby being controllably adhered to the inner wall of the digestive tract. Therefore, the classic BOOST boost circuit can be directly adopted. The circuit principle and circuit structure are more mature, which not only facilitates the setting of the second circuit board 55, but also facilitates the electrical connection between the boost circuit 513 and the PWM signal generating circuit 512. Figure 5 FIG. 5 is a circuit diagram of the boost circuit 513 .

[0065] In some embodiments, reference Figure 1 and Figure 4 The attachment trigger component also includes a battery 57 , which is electrically connected to the control circuit 511 .

[0066] It should be noted that the control circuit 511 is electrically connected to the battery 57, so that the control circuit 511 can control the battery 57 to power the image acquisition device 2, the PWM signal generating circuit 512, and the boost circuit 513. After the boost circuit 513 increases the voltage, the control circuit 511 can control the duration of the boost circuit 513's power supply to ensure that the hydrogel patch 4 adheres tightly to the inner wall of the digestive tract. When the hydrogel patch 4 is not in contact with the inner wall of the digestive tract, the control circuit 511 can control the boost circuit 513 to be de-energized to prevent the cathode 53 and the hydrogel patch 4 from accidentally contacting the inner wall of the digestive tract during the hydrogel patch 4's movement within the digestive tract, causing the hydrogel patch 4 to adhere to the normal inner wall of the digestive tract and delay treatment of the affected area.

[0067] In some embodiments, reference Figure 1 The wireless transmission device 56 is a radio frequency wireless transmission antenna, which is wound around the outer side of the battery 57.

[0068] An RF antenna is a device that radiates RF signals from a transmission line into the air or receives them from the air back onto the transmission line. It can also be considered an impedance converter or an energy converter. It converts guided waves propagating along the transmission line into electromagnetic waves propagating in an unbounded medium, and vice versa. In an RFID system, the antenna is responsible for transmitting RF signals from the reader to the tag and receiving the return signal from the tag.

[0069] It should be noted that the hydrogel patch delivery device of the embodiment of the present application enters the human body by swallowing, and also uses the external magnetic field to control the magnetic device 3 of the hydrogel patch delivery device to realize the multi-degree-of-freedom movement of the hydrogel patch delivery device in the digestive tract, so that the hydrogel patch delivery device can move to any position in the digestive tract, and the entire digestive tract can be inspected and treated. Therefore, the volume of the hydrogel patch delivery device needs to be made as small as possible.

[0070] The embodiment of the present application wraps the RF wireless transmission antenna around the outer side of the battery 57, which not only makes the RF wireless transmission antenna more firmly installed in the shell 1, but also enables the RF wireless transmission antenna to quickly and effectively transmit signals when the hydrogel patch delivery device performs multi-degree-of-freedom movement in the digestive tract, making it convenient for doctors to diagnose the inner wall of the digestive tract based on the images taken by the image acquisition device 2, and for the hydrogel patch delivery device to treat the diseased area on the inner wall of the digestive tract; it also enables the RF wireless transmission antenna to occupy less space when installed in the shell 1, which is beneficial to reducing the volume of the hydrogel patch delivery device, making the hydrogel patch delivery device easier to swallow, and at the same time being able to move more smoothly to various positions in the digestive tract for inspection and treatment, thereby increasing the treatment range of the hydrogel patch delivery device for the digestive tract.

[0071] Furthermore, the RF wireless transmission antenna can be made of a soft, bendable material. This makes it easier for workers to wrap the RF wireless transmission antenna around the outer side of battery 57, without damaging the RF wireless transmission antenna during the wrapping process, nor affecting the signal transmission performance of the RF wireless transmission antenna. To more quickly and conveniently wrap the RF wireless transmission antenna around the outer side of battery 57, battery 57 can be configured as a cylindrical shape. This creates a cylindrical outer surface, further facilitating wrapping of the RF wireless transmission antenna.

[0072] Specifically, based on the above-mentioned settings, the steps for installing the battery 57 and the RF wireless transmission antenna in the shell 1 can be to first wrap the RF wireless transmission antenna around the outer side of the battery 57, and then install the battery 57 into the shell 1. In this way, only the installation of the battery 57 needs to be completed, which is equivalent to completing the installation of the RF wireless transmission antenna at the same time, greatly improving the production and assembly efficiency of the hydrogel patch delivery device.

[0073] In some embodiments, reference Figure 1 The shell 1 includes a cylindrical shell body 11 and a first cover body 12 and a second cover body 13 respectively covering the two ends of the shell body 11; the first cover body 12 has a transparent window, and the lighting surface of the image acquisition device 2 is opposite to the transparent window; along the axial direction X of the shell body 11, the image acquisition device 2, the battery 57, the first circuit board 54, the magnetic device 3 and the second circuit board 55 are arranged in sequence.

[0074] In the embodiment of the present application, the shell 1 is configured as a split structure. When installing and manufacturing the hydrogel patch delivery device, the image acquisition device 2, the battery 57, the first circuit board 54, the magnetic device 3 and the second circuit board 55 can be installed in sequence into the shell body 11 first, and then the first cover body 12 and the second cover body 13 can be installed at both ends of the shell body 11. In this way, the difficulty of installing the image acquisition device 2, the battery 57, the first circuit board 54, the magnetic device 3 and the second circuit board 55 in the shell body 11 can be reduced, thereby improving the installation and manufacturing efficiency of the hydrogel patch delivery device.

[0075] It should be noted that the first cover 12 has a transparent window. A specific implementation method can be to use a transparent material to make the first cover 12, in which case the entire first cover 12 can serve as the transparent window; or a hole can be opened in the first cover 12, and then a transparent window made of transparent material covers the hole in the first cover 12. This embodiment of the present application is not specifically limited.

[0076] In the embodiment of the present application, the shell body 11 is set to be cylindrical, which can facilitate the movement of the hydrogel patch delivery device in the digestive tract. The image acquisition device 2, the battery 57, the first circuit board 54, the magnetic device 3 and the second circuit board 55 are arranged in sequence along the axial direction X of the shell body 11. This not only makes the image acquisition device 2, the battery 57, the first circuit board 54, the magnetic device 3 and the second circuit board 55 more compactly distributed in the shell body 11, which is conducive to reducing the overall volume of the hydrogel patch delivery device, but also makes the electrical connection operation between the various components inside the shell body 11 of the hydrogel patch delivery device more convenient after they are installed.

[0077] In some embodiments, reference Figure 1 The shell body 11 is cylindrical. That is, the outer side of the shell body 11 is a cylindrical surface. In this way, when the hydrogel patch delivery device moves in the digestive tract, the outer side of the hydrogel patch delivery device that contacts the inner wall of the digestive tract is a circular arc surface. Compared with the shell body 11 being configured as a prism, the sharp corners of the outer side of the hydrogel patch delivery device may contact the inner wall of the digestive tract and cause pain to the patient. The outer side of the hydrogel patch delivery device in the embodiment of the application that contacts the inner wall of the digestive tract is a circular arc surface, which not only does not cause pain to the patient, but also facilitates smooth movement of the hydrogel patch delivery device in the digestive tract.

[0078] Furthermore, when the shell body 11 is cylindrical, the first cover 12 and the second cover 13 can be correspondingly configured to be arc-shaped, that is, after the first cover 12 is installed at one end of the shell body 11, the first cover 12 protrudes in the direction away from the shell body 11, and the surface of the first cover 12 facing away from the shell body 11 is a smooth arc surface; after the second cover 13 is installed at the other end of the shell body 11, the second cover 13 protrudes in the direction away from the shell body 11, and the surface of the second cover 13 facing away from the shell body 11 is a smooth arc surface. In this way, the entire outer surface of the hydrogel patch delivery device is an arc surface, and when the shell 1 of the hydrogel patch delivery device moves forward, it can be smoother, and it will not cause pain to the patient if it touches the inner wall of the digestive tract during movement.

[0079] In some embodiments, the outer surface of the housing 11 can be an arc-shaped surface, and the first cover 12 and the second cover 13 can be configured in a corresponding arc shape. In this case, the housing 1 as a whole is ellipsoidal. This can also make the housing 1 of the hydrogel patch delivery device move forward more smoothly, and will not cause pain to the patient if it touches the inner wall of the digestive tract during movement.

[0080] In some embodiments, reference Figure 1The shell body 11 is provided with a mounting opening 10 that passes through the shell body 11, and a mounting plate 14 is provided at the position where the mounting opening 10 is opened on the inner side of the shell body 11. The mounting opening 10 and the mounting plate 14 enclose a receiving space; the anode sheet 52 is provided on the mounting plate 14; the hydrogel patch 4 is located in the receiving space, and a pressing block 6 is provided on the outer side of the shell body 11, and the pressing block 6 abuts against the hydrogel patch 4.

[0081] Through the above arrangement, one side surface of the anode sheet 52 faces the inside of the shell body 11, and the other side surface of the anode sheet 52 faces the hydrogel patch 4. It can be electrically connected to the boost control module 51 set inside the shell body 11, and can also achieve contact connection with the hydrogel patch 4. The design is more reasonable and is conducive to reducing the volume of the hydrogel patch delivery device. The hydrogel patch 4 is set in the accommodating space formed by the installation opening 10 and the installation plate 14. In this way, the hydrogel patch 4 is exposed outside the shell body 11. When it is necessary to treat the lesion area on the inner wall of the digestive tract, the hydrogel patch 4 can directly contact the inner wall of the digestive tract and control the hydrogel patch 4 to adhere to the inner wall of the digestive tract through the boost control module 51, thereby achieving treatment of the lesion area on the inner wall of the digestive tract, and the treatment efficiency is higher.

[0082] It should be noted that, since the hydrogel patch 4 is located in the accommodation space formed by the mounting opening 10 and the mounting plate 14, during the multi-degree-of-freedom movement of the hydrogel patch delivery device in the human digestive tract, in order to prevent the hydrogel patch 4 from falling from the accommodation space and affecting the subsequent treatment of the diseased area on the inner wall of the digestive tract, the embodiment of the present application is provided with a pressing block 6 on the outer side of the shell body 11, and the hydrogel patch 4 is pressed tightly in the accommodation space by the pressing block 6, which not only prevents the hydrogel patch 4 from falling from the accommodation space, but also enables the hydrogel patch 4 to be in close contact with the anode plate 52, which is conducive to the hydrogel patch 4 to be closely adhered to the inner wall of the digestive tract through an electrical adhesion reaction when it contacts the inner wall of the digestive tract.

[0083] The hydrogel patch 4 of the embodiment of the present application is prepared according to the above-mentioned preparation method. The hydrogel patch 4 has a certain toughness and can be deformed. The elastic modulus of the hydrogel patch 4 is 18KPa-22KPa. Therefore, after the hydrogel patch 4 adheres to the inner wall of the digestive tract, the hydrogel patch delivery device can be controlled to move away from the inner wall of the digestive tract as a whole by an external magnetic field. The adhesion force between the hydrogel patch 4 and the inner wall of the digestive tract is much greater than the thrust applied by the external magnetic field to the hydrogel patch delivery device and the pressure applied by the pressing block 6 to the hydrogel patch 4. Therefore, the hydrogel patch 4 will break away from the accommodation space and adhere to the inner wall of the digestive tract, completing the treatment of the lesion area.

[0084] In some embodiments, reference Figure 1 and Figure 3The shell body 11 is cylindrical, and the mounting plate 14 is an arc-shaped plate; the mounting plate 14 is provided with an embedding opening 140 that passes through the mounting plate 14, and the anode sheet 52 is embedded in the embedding opening 140; the surface of the anode sheet 52 close to the hydrogel patch 4 and the surface of the mounting plate 14 close to the hydrogel patch 4 are located on the same cylindrical surface, and the anode sheet 52 is in contact with the hydrogel patch 4.

[0085] It should be noted that since the hydrogel patch 4 is exposed outside the housing 1, when the housing body 11 is cylindrical, the hydrogel patch 4 can also be configured to have an arc shape, so that the overall outer surface of the hydrogel patch delivery device remains in an arc state. In the above configuration, the mounting plate 14 is configured as an arc plate. In this case, the anode plate 52 embedded in the insertion opening 140 will have an arc shape, thereby allowing the anode plate 52 to fit the entire surface of the hydrogel patch 4, achieving a better fit and facilitating the hydrogel patch 4 to adhere tightly to the inner wall of the digestive tract.

[0086] In addition, the surface of the anode sheet 52 on one side close to the hydrogel patch 4 and the surface of the mounting plate 14 on one side close to the hydrogel patch 4 are located on the same cylindrical surface, so that the hydrogel patch 4 can be tightly fitted with both the anode sheet 52 and the mounting plate 14 when located in the accommodating space, which is conducive to setting the hydrogel patch 4 more firmly in the accommodating space and preventing the hydrogel patch 4 from falling during the movement of the hydrogel patch delivery device.

[0087] In the embodiment of the present application, the hydrogel patch delivery device moves in the human digestive tract, and the hydrogel patch delivery device has a corresponding circuit inside. Therefore, the inside of the hydrogel patch delivery device needs to be kept sealed. The first cover body 12 and the second cover body 13 are sealed and connected to the two ends of the shell body 11. The mounting plate 14 is sealed and connected to the mounting opening 10. After the anode sheet 52 is embedded in the embedding port 140, it needs to be kept sealed with the side wall of the embedding port 140. In this way, the inside of the shell 1 of the hydrogel patch delivery device is in a sealed state, so that the circuits electrically connected to the various components arranged inside the shell 1 will not be affected by the liquid in the digestive tract and damaged, and the hydrogel patch delivery device can normally realize the inspection and treatment of the inner wall of the digestive tract.

[0088] In some embodiments, reference Figure 1 and Figure 2 The shell body 11 is cylindrical, and a groove 111 is provided on the outer side of the shell body 11, and the groove 111 is arranged around the mounting opening 10; the cathode sheet 53 is arranged in the groove 111, and the side surface of the cathode sheet 53 away from the bottom of the groove 111 is located on the same cylindrical surface as the outer side of the shell body 11.

[0089] It should be noted that a groove 111 is provided on the outer side of the shell body 11, and the cathode sheet 53 is provided in the groove 111. In this way, when the hydrogel patch delivery device is close to the lesion area of the inner wall of the digestive tract for treatment, in addition to the hydrogel patch 4 being close to the inner wall of the digestive tract, the cathode sheet 53 will also be close to the inner wall of the digestive tract. In this way, when the boost circuit 513 is energized, the boost circuit 513, the cathode sheet 53, the mucosa of the inner wall of the digestive tract, the hydrogel patch 4 and the anode sheet 52 will be connected to form a complete circuit. Since the mucosal tissue of the inner wall of the digestive tract is anionic, when the boost circuit 513 increases the voltage, the hydrogel patch 4 carrying cations will be driven by the voltage to produce cross-links with the biological mucosal tissue with anionic charge, thereby achieving a controllable adhesion effect. The groove 111 is set around the installation opening 10, so that the cathode sheet 53 is distributed around the hydrogel patch 4, which can enhance the cross-linking reaction effect between the hydrogel patch 4 and the mucosal tissue of the inner wall of the digestive tract, making the controllable adhesion effect between the hydrogel patch 4 and the inner wall of the digestive tract better.

[0090] In addition, the side surface of the cathode plate 53 away from the bottom of the groove 111 and the outer side surface of the shell body 11 can be located on the same cylindrical surface, so that the outer side surface of the hydrogel patch delivery device can remain flat, and the setting of the cathode plate 53 will not cause the shell 1 to contact the inner wall of the digestive tract and cause pain to the patient.

[0091] Of course, in the radial direction of the shell body 11, the side surface of the cathode plate 53 away from the bottom of the groove 111 is set to be higher than the outer side surface of the shell body 11, so that when the hydrogel patch delivery device is close to the diseased area on the inner wall of the digestive tract for treatment, the cathode plate 53 will be tightly attached to the inner wall of the digestive tract together with the hydrogel patch 4, thereby realizing controllable adhesion of the hydrogel patch 4 to the inner wall of the digestive tract.

[0092] Specifically, a through hole can be opened at the bottom of the groove 111, and the cathode sheet 53 can be electrically connected to the boost circuit 513 on the second circuit board 55 provided in the shell body 11 through the through hole. In order to ensure that the interior of the shell 1 remains sealed, the cathode sheet 53 can be pasted in the groove 111, or the gap between the cathode sheet 53 and the side wall of the groove 111 can be filled with sealant. The embodiment of the present application does not make specific limitations, as long as it can effectively prevent the through hole opened at the bottom of the groove 111 from connecting the interior of the shell 1 and the outside world.

[0093] In some embodiments, reference Figure 6 A mounting seat 7 is provided in the shell 1 , and the magnetic device 3 is provided on the mounting seat 7 . There is a gap between a side surface of the magnetic device 3 away from the mounting seat 7 and the inner side surface of the shell 1 .

[0094] It should be noted that a mounting seat 7 is provided in the shell 1 for setting the magnetic device 3, which can make the magnetic device 3 installed more firmly in the shell 1 and will not be displaced due to the control of the external magnetic field, thereby enabling the hydrogel patch delivery device to achieve multi-degree-of-freedom movement under the control of the external magnetic field, accurately move to the target position, and accurately adhere the hydrogel patch 4 to the lesion area on the inner wall of the digestive tract, thereby achieving better therapeutic effects.

[0095] In the embodiment of the present application, when the shell body 11 is cylindrical, the mounting seat 7 is arranged in the shell body 11, and the mounting seat 7 can be set to a semicircular ring shape, and the magnetic device 3 is set to a cylindrical shape, and the magnetic device 3 and the mounting seat 7 are clearance-fitted (the clearance is zero), or the magnetic device 3 and the mounting seat 7 are interference-fitted. In this way, after the magnetic device 3 is installed on the mounting seat 7, there will be a gap between the side surface of the magnetic device 3 away from the mounting seat 7 and the inner side surface of the shell 1. This gap can facilitate the electrical connection of the PWM signal generating circuit 512 on the first circuit board 54 and the boost circuit 513 on the second circuit board 55, so that the various components installed inside the shell 1 of the hydrogel patch delivery device can be reasonably distributed while achieving electrical connection, thereby reducing the overall volume of the hydrogel patch delivery device.

[0096] refer to Figure 7 The present invention provides a method for adhering a hydrogel patch, which is applied to a hydrogel patch delivery device as described in any of the above embodiments, and includes the following steps:

[0097] S101. Acquire images of the digestive tract.

[0098] S102, attaching the hydrogel patch 4 and the cathode sheet 53 to the target attachment position.

[0099] S103 , increasing the voltage across the hydrogel patch to a threshold voltage, so that the hydrogel patch 4 adheres to the inner wall of the digestive tract.

[0100] S104, separating the shell and the hydrogel patch 4.

[0101] The hydrogel patch delivery device of the above embodiment adopts the hydrogel patch adhesion method of the embodiment of the present application, which can make the hydrogel patch 4 adhere to the diseased area of the inner wall of the digestive tract in a controllable manner through the principle of electrical adhesion, and the adhesion effect is better; the hydrogel patch 4 is mounted on the shell 1 and can move synchronously with the movement of the magnetic device 3, so that it can be moved to any position in the digestive tract, expanding the delivery range of the hydrogel patch 4 and achieving full-area treatment of the inner wall of the digestive tract; first obtain the image of the digestive tract, and then transmit it to the doctor for diagnosis, and then adhere the hydrogel patch 4 to the diseased area of the inner wall of the digestive tract for treatment, so that diagnosis and treatment can be carried out together, which not only improves the treatment efficiency, but also does not cause too much pain to the patient.

[0102] The above description is merely a specific embodiment of the present application, but the scope of protection of the present application is not limited thereto. Any changes or substitutions that can be easily conceived by a person skilled in the art within the technical scope disclosed in this application should be included in the scope of protection of this application. Therefore, the scope of protection of this application should be based on the scope of protection of the claims.

Claims

1. A hydrogel patch delivery device, characterized in that include: Housing (1); An image acquisition device (2), disposed in the housing (1), for acquiring images of the digestive tract; A magnetic device (3) is disposed in the housing (1); A hydrogel patch (4) is provided on the outer side of the shell (1), and the hydrogel patch (4) includes cations; An attachment trigger assembly comprises a boost control module (51) and an anode plate (52) disposed in the housing (1), and a cathode plate (53) disposed on the outer side of the housing (1), wherein the anode plate (52) contacts the hydrogel patch (4), and both the anode plate (52) and the cathode plate (53) are electrically connected to the boost control module (51); The boost control module (51) is configured to increase the voltage across the hydrogel patch (4) to a threshold voltage when the cathode plate (53) and the hydrogel patch (4) are in contact with the inner wall of the digestive tract respectively, so as to cause the hydrogel patch (4) to adhere to the inner wall of the digestive tract, wherein the threshold voltage is greater than a turn-on voltage at which the hydrogel patch (4) undergoes an electroadhesion effect.

2. The hydrogel patch delivery device according to claim 1, wherein The attachment trigger assembly further comprises a first circuit board (54), a second circuit board (55) and a wireless transmission device (56) arranged in the housing (1); The boost control module (51) comprises a control circuit (511) and a PWM signal generating circuit (512) provided on the first circuit board (54), and a boost circuit (513) provided on the second circuit board (55); The control circuit (511) is electrically connected to the image acquisition device (2), the PWM signal generating circuit (512), and the wireless transmission device (56), respectively; the boost circuit (513) is electrically connected to the PWM signal generating circuit (512), the anode plate (52), and the cathode plate (53), respectively.

3. The hydrogel patch delivery device according to claim 2, wherein: The attachment trigger component further includes a battery (57), and the battery (57) is electrically connected to the control circuit (511).

4. The hydrogel patch delivery device according to claim 3, wherein: The wireless transmission device (56) is a radio frequency wireless transmission antenna, and the radio frequency wireless transmission antenna is wound around the outer side of the battery (57).

5. The hydrogel patch delivery device according to claim 3 or 4, characterized in that The housing (1) comprises a cylindrical shell body (11) and a first cover body (12) and a second cover body (13) respectively covering two ends of the shell body (11); The first cover (12) has a transparent window, and the light-collecting surface of the image acquisition device (2) is opposite to the transparent window; Along the axial direction of the shell body (11), the image acquisition device (2), the battery (57), the first circuit board (54), the magnetic device (3) and the second circuit board (55) are arranged in sequence.

6. The hydrogel patch delivery device according to claim 5, characterized in that The shell body (11) is provided with a mounting opening (10) passing through the shell body (11); a mounting plate (14) is provided at the position where the mounting opening (10) is opened on the inner side surface of the shell body (11); the mounting opening (10) and the mounting plate (14) enclose and form a receiving space; The anode plate (52) is arranged on the mounting plate (14); The hydrogel patch (4) is located in the accommodating space, and a pressing block (6) is provided on the outer side surface of the shell body (11), and the pressing block (6) abuts against the hydrogel patch (4).

7. The hydrogel patch delivery device according to claim 6, wherein: The shell body (11) is cylindrical, and the mounting plate (14) is an arc-shaped plate; The mounting plate (14) is provided with an embedding opening (140) penetrating the mounting plate (14), and the anode plate (52) is embedded in the embedding opening (140); The surface of the anode sheet (52) close to the hydrogel patch (4) and the surface of the mounting plate (14) close to the hydrogel patch (4) are located on the same cylindrical surface, and the anode sheet (52) is bonded to the hydrogel patch (4).

8. The hydrogel patch delivery device according to claim 6 or 7, characterized in that: The shell body (11) is cylindrical, and a groove (111) is provided on the outer side surface of the shell body (11), and the groove (111) is arranged around the installation opening (10); The cathode plate (53) is disposed in the groove (111), and a surface of the cathode plate (53) away from the bottom of the groove (111) and an outer surface of the shell body (11) are located on the same cylindrical surface.

9. The hydrogel patch delivery device according to any one of claims 1-4, 6-7, characterized in that: A mounting seat (7) is provided in the housing (1), the magnetic device (3) is provided on the mounting seat (7), and a gap exists between a side surface of the magnetic device (3) away from the mounting seat (7) and an inner side surface of the housing (1).

10. A hydrogel patch adhesion method, applied to the hydrogel patch delivery device according to any one of claims 1 to 9, characterized in that: include: Acquire images of the digestive tract; Attaching the hydrogel patch and the cathode patch to the target attachment position; increasing the voltage across the hydrogel patch to a threshold voltage so that the hydrogel patch adheres to the inner wall of the digestive tract; The shell is separated from the hydrogel patch.

Images