Constant temperature water bath equipment for production of medical intermediates

Abstract

The application discloses a constant-temperature water bath equipment for medical intermediate production and relates to the technical field of medical intermediate production. The constant-temperature water bath equipment for medical intermediate production comprises a water bath equipment main body, a material barrel rotatably connected to the inside of the water bath equipment main body and a heating equipment assembled in the inside of the water bath equipment main body. A power rod is assembled at the side of the water bath equipment main body, and the material barrel penetrates through the water bath equipment main body and is driven by the power rod. The constant-temperature water bath equipment for medical intermediate production adds water into the water bath equipment main body, adds raw materials into the material barrel, starts the power rod, drives the material barrel to rotate, cooperates with a chain wheel one, a chain, a gear ring, a chain wheel two, a gear one, a stress rod one and a gear two, so that a stirring plate in the material barrel stirs the raw materials in the opposite rotating direction of the material barrel, the temperature difference between the raw materials close to the central part of the material barrel and the raw materials close to the inner wall of the material barrel is small, and the device is more easy to use.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical intermediate production technology, specifically to a constant temperature water bath device for pharmaceutical intermediate production. Background Technology

[0002] Pharmaceutical intermediates are chemical substances used in the pharmaceutical process to synthesize active drug components; they are typically intermediate products in drug synthesis. Constant temperature water bath equipment plays a crucial role in the production of pharmaceutical intermediates, primarily by providing a constant temperature environment to ensure the stable conduct of chemical reactions. The production of pharmaceutical intermediates usually involves multiple chemical reactions, many of which have very strict temperature requirements. Temperatures that are too high or too low can affect reaction rates, product purity, and may even lead to reaction failure. Therefore, maintaining a constant reaction temperature is of great significance for improving production efficiency and ensuring the quality of pharmaceutical intermediates.

[0003] Chinese patent CN217763923U, authorized and published on November 8, 2022, discloses a constant temperature water bath device for the production of pharmaceutical intermediates. The device includes a water bath and a motor located inside the water bath. Multiple heating plates are installed on the inner wall of the water bath. The output end of the motor is connected to a material tank. Multiple swirl plates are installed on the inner wall of the material tank. Multiple swirl vanes are installed on the outer wall of the material tank, each located between two heating plates.

[0004] In the aforementioned application, the heat exchange efficiency is improved by driving the material tank to rotate, thereby causing the constant temperature water inside the water bath equipment to rotate continuously. However, the raw material inside the material tank remains relatively stationary due to inertia, resulting in a large temperature difference between the raw material near the center of the material tank and the raw material close to the inner wall of the material tank, which affects the use of the device. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a constant temperature water bath for the production of pharmaceutical intermediates, solving the problems mentioned in the background section. To achieve the above objectives, this invention is implemented through the following technical solution: a constant temperature water bath for the production of pharmaceutical intermediates, comprising:

[0006] The main body of the water bath equipment has a material tank rotatably connected inside, and a heating device is installed inside the main body of the water bath equipment.

[0007] A power rod is mounted on the side of the main body of the water bath equipment, and the material tank penetrates the main body of the water bath equipment and is driven by the power rod.

[0008] A sprocket is fixedly connected to the outside of the power rod, a force-bearing rod is rotatably connected inside the material bucket, a transmission component for transmission is assembled between the sprocket and the force-bearing rod, an agitator is fixedly connected to the outside of the force-bearing rod, a treatment component for scraping scale is assembled inside the main body of the water bath equipment, and an auxiliary component for unclogging scale is assembled inside the main body of the water bath equipment.

[0009] Preferably, the transmission component includes a chain mounted on the outside of a sprocket, a gear ring rotatably connected to the bottom of the water bath equipment body, a sprocket two fixedly connected to the outside of the gear ring, a gear one rotatably connected to the bottom of the water bath equipment body, and a gear two fixedly connected to the outside of the force-bearing rod. This device design allows the agitator plate to stir the raw material in the material tank in the opposite direction of rotation to the material tank, resulting in a smaller temperature difference between the raw material near the center of the material tank and the raw material close to the inner wall of the material tank, making the device easier to use.

[0010] Preferably, the end of the chain furthest from the first sprocket is fitted to the outer side of the second sprocket.

[0011] Preferably, the gear is located inside the gear ring and is in a meshing state with the gear ring.

[0012] Preferably, the processing assembly includes a transmission rod one mounted on the outside of a force-bearing rod one, a brush plate fixedly connected to the side of the transmission rod one, a hydraulic chamber one mounted on the outside of the force-bearing rod one, a piston sliding block slidably connected to the inner wall of the hydraulic chamber one via a spring one, an arc-shaped plate slidably connected to the side of the hydraulic chamber one via a piston one, a transmission rod two slidably connected to the top of the transmission rod one, and a force-bearing plate connected to the side of the brush plate via an elastic telescopic block. By configuring the processing assembly, an additional force can be applied to the brush plate, improving the device's cleaning effect on scale.

[0013] Preferably, the transmission rod two is located on the side of the arc-shaped plate and is in contact with the arc-shaped plate.

[0014] Preferably, the force-bearing plate is located on the side of the second transmission rod and is in contact with the second transmission rod.

[0015] Preferably, the auxiliary components include a transmission rod three and a torsion spring rod rotatably connected inside the main body of the water bath device. A bevel gear one is fixedly connected to the outer side of the force-bearing rod one, a bevel gear two is fixedly connected to one end of the transmission rod three, and a cam is fixedly connected to the other end of the transmission rod three. A transmission rod four and a drain rod are fixedly connected to the outer side of the torsion spring rod. The auxiliary components allow the drain rod to reciprocate at the drain outlet, preventing scale removed from the inner wall from clogging the outlet, making the device easier to use in this situation.

[0016] Preferably, the second bevel gear is located on the side of the first bevel gear and is in mesh with the first bevel gear.

[0017] Preferably, the transmission rod is located at the top of the cam and is in contact with the cam.

[0018] This invention provides a constant temperature water bath device for the production of pharmaceutical intermediates. It has the following beneficial effects:

[0019] (1) The constant temperature water bath equipment for the production of pharmaceutical intermediates is used to add water into the main body of the water bath equipment, add raw materials into the material tank, start the power rod to drive the material tank to rotate, and cooperate with sprocket one, chain, gear ring, sprocket two, gear one, force rod one and gear two to make the stirring plate stir the raw materials in the material tank in the opposite direction of rotation to the material tank. The temperature difference between the raw materials near the center of the material tank and the raw materials close to the inner wall of the material tank is small, making the device easier to use.

[0020] (2) When the force rod is in a rapid rotation state, the constant temperature water bath equipment for the production of pharmaceutical intermediates can drive the transmission rod to rotate, so that the transmission rod drives the brush plate to rotate, thereby scraping off the scale that may be attached to the inner wall of the main body of the water bath equipment. In addition, with the hydraulic chamber, spring, piston sliding block, arc plate, transmission rod, elastic telescopic block and force plate, an additional force can be applied to the brush plate, which improves the cleaning effect of the device on scale.

[0021] (3) After the constant temperature water bath equipment for the production of pharmaceutical intermediates is put into use, the cleaning liquid is introduced into the main body of the water bath equipment for cleaning. During this process, the force rod one is still in a state of rapid rotation. In conjunction with the bevel gear one, transmission rod three, torsion spring rod, bevel gear two, cam and transmission rod four, the unblocking rod moves back and forth at the drain port to prevent the scale cleaned from the inner wall from clogging the drain port, making the equipment easier to use in this situation. Attached Figure Description

[0022] Figure 1 This is a three-dimensional structural diagram of some parts of the present invention;

[0023] Figure 2 This is a schematic diagram of the overall cross-sectional three-dimensional structure of the present invention;

[0024] Figure 3 This is a schematic diagram of the overall cross-sectional three-dimensional structure from another perspective of the present invention;

[0025] Figure 4 This is a three-dimensional structural diagram of some parts of the present invention;

[0026] Figure 5 This is a three-dimensional structural diagram of the processing component of the present invention;

[0027] Figure 6 This is a three-dimensional structural diagram of some parts of the processing component of the present invention;

[0028] Figure 7 This is a three-dimensional structural diagram of the auxiliary component of the present invention;

[0029] Figure 8 For the present invention Figure 7 Enlarged structural diagram at point A in the middle.

[0030] In the picture:

[0031] 100. Main body of water bath equipment; 200. Material bucket; 300. Power rod; 401. Sprocket 1; 402. Chain; 403. Gear ring; 404. Sprocket 2; 405. Gear 1; 406. Force rod 1; 407. Gear 2; 408. Agitator plate;

[0032] 500. Processing component; 501. Transmission rod one; 502. Brush plate; 503. Hydraulic chamber one; 504. Spring one; 505. Piston sliding block; 506. Arc plate; 507. Transmission rod two; 508. Elastic telescopic block; 509. Force plate;

[0033] 600. Auxiliary components; 601. Bevel gear one; 602. Transmission rod three; 603. Torsion spring rod; 604. Bevel gear two; 605. Cam; 606. Transmission rod four; 607. Unblocking rod. Detailed Implementation

[0034] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0035] Example 1, please refer to Figures 1-4 A constant temperature water bath device for the production of pharmaceutical intermediates, comprising:

[0036] The water bath equipment body 100 has a material tank 200 rotatably connected inside the water bath equipment body 100, and a heating device is installed inside the water bath equipment body 100.

[0037] The power rod 300 is mounted on the side of the main body 100 of the water bath equipment. The material tank 200 passes through the main body 100 of the water bath equipment and is driven by the power rod 300. Water is added into the main body 100 of the water bath equipment, and raw materials are added into the material tank 200. The heating equipment in the main body 100 of the water bath equipment maintains the water at a constant temperature. The power rod 300 is started, which drives the material tank 200 to rotate.

[0038] A sprocket 401 is fixedly connected to the outer side of the power rod 300. A force-bearing rod 406 is rotatably connected inside the material tank 200. A transmission component for transmission is assembled between the sprocket 401 and the force-bearing rod 406. The transmission component includes a chain 402 assembled on the outer side of the sprocket 401. A gear ring 403 is rotatably connected to the bottom of the water bath equipment body 100. A sprocket 404 is fixedly connected to the outer side of the gear ring 403. The end of the chain 402 away from the sprocket 401 is assembled on the outer side of the sprocket 404. When the power rod 300 rotates, it drives the sprocket 401 fixedly connected to it to rotate. This, in conjunction with the chain 402 assembled on the outer side of the sprocket 401, causes the sprocket 404, which is transmitted through the chain 402 to the sprocket 401, to rotate. Since the gear ring 403 is rotatably connected to the bottom of the water bath equipment body 100, the sprocket 404 drives the gear ring 403 fixedly connected to it to rotate.

[0039] A gear 405 is rotatably connected to the bottom of the main body 100 of the water bath equipment. Gear 405 is located inside the gear ring 403 and is meshed with the gear ring 403. A gear 407 is fixedly connected to the outside of the force-bearing rod 406. When the gear ring 403 is rotating, and gear 405 is also rotatably connected to the bottom of the main body 100 of the water bath equipment, gear 405 is constrained by the meshing gear ring 403 and gear 407. This causes the gear ring 403 to drive gear 405 to rotate in the same direction, and gear 405 is also rotating synchronously. Gear 405 can then drive gear 407 to rotate, and the rotation direction of gear 407 is opposite to that of the gear ring 403. This causes gear 407 to drive the force-bearing rod 406 fixedly connected to it to rotate rapidly.

[0040] An agitator plate 408 is fixedly connected to the outer side of the force-bearing rod 406. When the force-bearing rod 406 rotates rapidly, it drives the agitator plate 408 fixedly connected to it to rotate inside the material bucket 200. The rotation direction of the gear ring 403 is the same as the rotation direction of the material bucket 200, so that the rotation direction of the agitator plate 408 is opposite to the rotation direction of the material bucket 200. In this way, the agitator plate 408 can agitate the raw material inside the material bucket 200 in a rotation direction opposite to that of the material bucket 200. The raw material inside the material bucket 200 cannot be in a relatively stationary state with the material bucket 200 under the action of inertia. This makes the temperature difference between the raw material near the center of the material bucket 200 and the raw material close to the inner wall of the material bucket 200 smaller, making the device easier to use.

[0041] In use, water is added to the main body 100 of the water bath equipment, and raw materials are added to the material tank 200. The heating device inside the main body 100 of the water bath equipment maintains the water at a constant temperature. The power rod 300 is activated, which drives the material tank 200 to rotate. At this time, the power rod 300 drives the sprocket 401 fixedly connected to it to rotate. The chain 402 mounted on the outside of the sprocket 401 causes the sprocket 404, which is connected to the sprocket 401 via the chain 402, to rotate. Since the gear ring 403 is rotatably connected to the bottom of the main body 100 of the water bath equipment, the sprocket 404 drives the gear ring 403 fixedly connected to it to rotate. The gear 405 is also rotatably connected to the bottom of the main body 100 of the water bath equipment. At the same time, the gear 405 is restricted by the gear ring 403 and the gear 407 meshing with it. This causes the gear ring 403 to drive the gear 405 to rotate in the same direction, and the gear 405 to rotate synchronously on its own axis. The gear 405 then drives the gear 407 to rotate, and the rotation direction of the gear 407 is opposite to that of the gear ring 403. This causes the gear 407 to drive the force rod 406, which is fixedly connected to it, to rotate rapidly. The force rod 406 drives the agitator 408, which is fixedly connected to it, to rotate inside the material bucket 200. The rotation direction of the gear ring 403 is the same as that of the material bucket 200, so the rotation direction of the agitator 408 is opposite to that of the material bucket 200. In this way, the agitator 408 can agitate the raw material inside the material bucket 200 in a rotation direction opposite to that of the material bucket 200. The raw material inside the material bucket 200 cannot remain relatively stationary with respect to the material bucket 200 due to inertia.

[0042] Example 2, please refer to Figures 1-6Based on Embodiment 1, the main body 100 of the water bath equipment is equipped with a treatment component 500 for scraping scale. The treatment component 500 includes a transmission rod 501 mounted on the outside of the force rod 406. A brush plate 502 is fixedly connected to the side of the transmission rod 501. A hydraulic chamber 503 is mounted on the outside of the force rod 406. A piston sliding block 505 is slidably connected to the inner wall of the hydraulic chamber 503 by means of a spring 504. An arc plate 506 is slidably connected to the side of the hydraulic chamber 503 by means of a piston. When the force-bearing rod 406 is in a state of rapid rotation, it can drive the transmission rod 501 mounted on its outer side to rotate, so that the transmission rod 501 drives the brush plate 502 fixedly connected to it to rotate, so as to scrape off the scale that may be attached to the inner wall of the water bath equipment body 100. At the same time, the force-bearing rod 406 drives the hydraulic chamber 503 mounted on its outer side to rotate rapidly, so that the piston sliding block 505 in the hydraulic chamber 503 stretches the spring 504 under the action of centrifugal force and slides along the inner wall of the hydraulic chamber 503, thereby pushing the oil originally stored in the hydraulic chamber 503 to flow towards the side closer to the arc plate 506, causing the arc plate 506, which is connected to the hydraulic chamber 503 by a piston sliding connection, to extend out of the hydraulic chamber 503.

[0043] A second transmission rod 507 is slidably connected to the top of the first transmission rod 501. The second transmission rod 507 is located on the side of the arc-shaped plate 506 and is in contact with it. A force-bearing plate 509 is connected to the side of the brush plate 502 via an elastic telescopic block 508. The force-bearing plate 509 is located on the side of the second transmission rod 507 and is in contact with it. When the arc-shaped plate 506 extends during rotation, it can squeeze the second transmission rod 507. Because the second transmission rod 507 is slidably connected to the first transmission rod 501, it moves closer to the force-bearing plate 509. This applies an additional force to the brush plate 502 through the force-bearing plate 509 and the elastic telescopic block 508, improving the device's cleaning effect on scale.

[0044] When the device is no longer in use, the force-bearing rod 406 stops rotating. The piston sliding block 505 loses the centrifugal force and can be reset under the action of the spring 504. Similarly, the arc plate 506 is reset, the transmission rod 507 loses the effect of the arc plate 506, and both the force-bearing plate 509 and the elastic telescopic block 508 can be reset to facilitate the next use of the device.

[0045] In use, based on Embodiment 1, when the force-bearing rod 406 is in a rapid rotation state, it can drive the transmission rod 501 mounted on its outer side to rotate, causing the transmission rod 501 to drive the brush plate 502 fixedly connected to it to rotate, thereby scraping off the scale that may be attached to the inner wall of the water bath equipment body 100. At the same time, the force-bearing rod 406 drives the hydraulic chamber 503 mounted on its outer side to rotate rapidly, causing the piston sliding block 505 in the hydraulic chamber 503 to stretch the spring 504 under the action of centrifugal force and slide along the inner wall of the hydraulic chamber 503, thereby pushing the oil originally stored in the hydraulic chamber 503 to flow towards the side closer to the arc plate 506, driving the piston sliding connection between the hydraulic chamber 503 and the hydraulic chamber 503. The arc-shaped plate 506 extends from the hydraulic chamber 503. During this process of rotation, the arc-shaped plate 506 extends, which can squeeze the transmission rod 507. Since the transmission rod 507 is slidably connected to the transmission rod 501, the transmission rod 507 moves closer to the force plate 509, thereby applying an additional force to the brush plate 502 through the force plate 509 and the elastic telescopic block 508. When the device is no longer in use, the force rod 406 stops rotating, and the piston sliding block 505, without the centrifugal force, can reset under the action of the spring 504. Similarly, the arc-shaped plate 506 resets, and the transmission rod 507, without the effect of the arc-shaped plate 506, can also reset under the action of the elastic telescopic block 508.

[0046] Example 3, please refer to Figures 1-8 Based on Embodiment 1 and Embodiment 2, the main body 100 of the water bath equipment is equipped with an auxiliary component 600 for unclogging scale. The auxiliary component 600 includes a transmission rod 602 and a torsion spring rod 603 rotatably connected inside the main body 100 of the water bath equipment. A bevel gear 601 is fixedly connected to the outside of the force rod 406. A bevel gear 604 is fixedly connected to one end of the transmission rod 602. The bevel gear 604 is located on the side of the bevel gear 601 and is meshed with the bevel gear 601. A cam 605 is fixedly connected to the other end of the transmission rod 602. After the device is used, cleaning fluid is introduced into the main body 100 of the water bath equipment for cleaning. During this cleaning process, the force rod 406 is still rotating rapidly, which drives the bevel gear 601 fixedly connected to it to rotate. This causes the bevel gear 601 to drive the bevel gear 604 meshing with it to rotate. The bevel gear 604 drives the transmission rod 602 fixedly connected to it to rotate, which in turn drives the cam 605 fixedly connected to it to rotate.

[0047] A transmission rod 606 and a drain rod 607 are fixedly connected to the outer side of the torsion spring rod 603. The transmission rod 606 is located at the top of the cam 605 and is in contact with the cam 605. When the protruding part of the cam 605 rotates to the position of the transmission rod 606, it... Figure 8 As shown, cam 605 can press the transmission rod 606 and make it rotate counterclockwise at a certain angle. This causes the transmission rod 606 to drive the torsion spring rod 603 fixedly connected to it to rotate. The torsion spring rod 603 can then drive the unblocking rod 607 fixedly connected to it to rotate counterclockwise at a certain angle. When the protruding part of cam 605 continues to rotate and moves away from the transmission rod 606, the torsion spring rod 603 fixedly connected to the transmission rod 606 loses its restraint and can rotate in the opposite direction under its own action to reset. Similarly, the unblocking rod 607 resets. In this case, the unblocking rod 607 can move back and forth at the drain port, thereby preventing scale cleaned from the inner wall from clogging the drain port, making the device easier to use in this case.

[0048] In use, based on Embodiments 1 and 2, after the device is used, cleaning fluid is introduced into the main body 100 of the water bath equipment for cleaning. During this cleaning process, the force-bearing rod 406 remains in a rapidly rotating state, driving the bevel gear 601 fixedly connected to it to rotate. This causes the bevel gear 601 to drive the bevel gear 604 meshing with it to rotate. The bevel gear 604 then drives the transmission rod 602 fixedly connected to it to rotate, causing the transmission rod 602 to drive the cam 605 fixedly connected to it to rotate. When the protruding part of the cam 605 rotates to the transmission rod 606, ... Figure 8 As shown, cam 605 can squeeze transmission rod 606 and make it rotate counterclockwise at a certain angle. This causes transmission rod 606 to drive torsion spring rod 603, which is fixedly connected to it, to rotate. Torsion spring rod 603 can then drive unblocking rod 607, which is fixedly connected to it, to rotate counterclockwise at a certain angle. When the protruding part of cam 605 continues to rotate and moves away from transmission rod 606, torsion spring rod 603, which is fixedly connected to transmission rod 606, loses its restraint and can rotate in the opposite direction under its own action to reset. Similarly, this resets unblocking rod 607. In this case, unblocking rod 607 can move back and forth at the drain outlet, thereby preventing scale cleaned from the inner wall from clogging the drain outlet.

[0049] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A constant temperature water bath device for the production of pharmaceutical intermediates, characterized in that, include: The main body of the water bath equipment has a material tank rotatably connected inside, and a heating device is installed inside the main body of the water bath equipment. A power rod is mounted on the side of the main body of the water bath equipment, and the material tank penetrates the main body of the water bath equipment and is driven by the power rod. A sprocket is fixedly connected to the outside of the power rod, a force rod is rotatably connected inside the material bucket, a transmission component for transmission is assembled between the sprocket and the force rod, an agitator is fixedly connected to the outside of the force rod, a treatment component for scraping scale is assembled inside the main body of the water bath equipment, and an auxiliary component for unclogging scale is assembled inside the main body of the water bath equipment. The processing assembly includes a transmission rod 1 mounted on the outside of a force-bearing rod 1. A brush plate is fixedly connected to the side of the transmission rod 1. A hydraulic chamber 1 is mounted on the outside of the force-bearing rod 1. A piston sliding block is slidably connected to the inner wall of the hydraulic chamber 1 via a spring 1. An arc-shaped plate is slidably connected to the side of the hydraulic chamber 1 via a piston 1. A transmission rod 2 is slidably connected to the top of the transmission rod 1. A force-bearing plate is connected to the side of the brush plate via an elastic telescopic block. The transmission rod 2 is located on the side of the arc-shaped plate and is in contact with the arc-shaped plate. The force-bearing plate is located on the side of the transmission rod 2 and is in contact with the transmission rod 2.

2. The constant temperature water bath equipment for the production of pharmaceutical intermediates according to claim 1, characterized in that: The transmission component includes a chain mounted on the outside of a sprocket, a toothed ring rotatably connected to the bottom of the main body of the water bath equipment, a sprocket fixedly connected to the outside of the toothed ring, a gear rotatably connected to the bottom of the main body of the water bath equipment, and a gear 2 fixedly connected to the outside of the force-bearing rod.

3. The constant temperature water bath equipment for the production of pharmaceutical intermediates according to claim 2, characterized in that: The end of the chain furthest from the first sprocket is fitted onto the outer side of the second sprocket.

4. The constant temperature water bath equipment for the production of pharmaceutical intermediates according to claim 2, characterized in that: The gear is located inside the gear ring and is in a meshing state with the gear ring.

5. The constant temperature water bath equipment for the production of pharmaceutical intermediates according to claim 1, characterized in that: The auxiliary components include a transmission rod three and a torsion spring rod rotatably connected inside the main body of the water bath equipment. A bevel gear one is fixedly connected to the outside of the force-bearing rod one. A bevel gear two is fixedly connected to one end of the transmission rod three. A cam is fixedly connected to the other end of the transmission rod three. A transmission rod four and a dredging rod are fixedly connected to the outside of the torsion spring rod respectively.

6. The constant temperature water bath equipment for the production of pharmaceutical intermediates according to claim 5, characterized in that: The second bevel gear is located on the side of the first bevel gear and is in mesh with the first bevel gear.

7. A constant temperature water bath device for the production of pharmaceutical intermediates according to claim 5, characterized in that: The transmission rod is located at the top of the cam and is in contact with the cam.

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