Adjustable rat intervertebral disc degeneration molding device

Abstract

The invention relates to the field of animal experiment testing devices, in particular to an adjustable rat intervertebral disc degeneration modeling device which comprises a base body, a first kirschner wire used for being fixed to the vertebra of a rat tail is arranged on the base body in a penetrating mode, a guide assembly is installed on the base body, and two kirschner wire fixing blocks are movably installed on the guide assembly; and a second kirschner wire is arranged on the two kirschner wire fixing blocks in a penetrating manner. When the Kirschner wire fixing block is driven by the adjusting assembly to perform displacement change, not only can the second Kirschner wire generate a compression function, but also the second Kirschner wire can realize a bending function, so that the bending compression or stretching of a rat caudal vertebra at a specific angle can be realized, and the bending compression condition of an intervertebral disc can be really simulated; meanwhile, the compression and bending force of the second kirschner wire can be freely adjusted, so that the deviation between an experimental result and an actual physiological condition can be remarkably reduced through the adjusting mode, and the real mechanism of occurrence and development of diseases can be accurately reflected.

Description

Technical Field

[0001] The invention relates to the field of animal experiment testing devices, and in particular to an adjustable rat intervertebral disc degeneration modeling device. Background Art

[0002] In the field of biomedical research, rats are commonly used as experimental animals, and their tail compression experiments are of great significance for exploring the mechanisms of intervertebral disc degeneration and evaluating the effectiveness of treatments. However, the experimental devices currently used for rat tail compression on the market have many technical bottlenecks, which seriously affect the accuracy, flexibility, and reliability of the experiments. The technical bottlenecks are as follows: 1. In the existing rat tail compression device, the connection method between the Kirschner wire and the fixed block is relatively cumbersome, which easily leads to a lot of time-consuming precise alignment during the installation process and is inconvenient to use.

[0003] 2. Rats of different body sizes and growth stages have significant differences in the size and mechanical properties of their tail vertebrae. Existing traditional rat tail compression devices usually have a fixed compression volume and cannot be freely adjusted, thus failing to meet diverse experimental needs.

[0004] 3. The existing rat tail compression device cannot achieve bending compression at a specific angle, and thus cannot simulate the actual bending and compression of the intervertebral disc. This causes a large deviation between the experimental results and the actual physiological conditions, making it difficult to accurately reflect the true mechanism of disease occurrence and development. In summary, the existing rat tail compression device has obvious defects in structural design, function realization, data monitoring and fixation method. There is an urgent need for a new adjustable device to solve the above problems and improve the scientificity, accuracy and safety of the experiment. Summary of the Invention

[0005] The present invention provides an adjustable rat intervertebral disc degeneration modeling device to solve the problems raised in the above background technology.

[0006] In order to solve the above technical problems, the technical solution adopted by the present invention is: An adjustable rat intervertebral disc degeneration modeling device includes a base body, a first Kirschner wire for fixing to the coccyx of the rat's tail is passed through the base body, and a guide assembly is installed on the base body, two Kirschner wire fixing blocks are movably installed on the guide assembly, and a second Kirschner wire is commonly passed through the two Kirschner wire fixing blocks, and an adjustment assembly is provided on the guide assembly, the adjustment assembly is used to drive the Kirschner wire fixing blocks to produce an angular offset to cause the second Kirschner wire to produce a tilting movement, and a thin film pressure sensor for pressure detection is provided between the adjustment assembly and the moving block in the guide assembly, and one end of the signal transmission line of the thin film pressure sensor is electrically connected to a digital display.

[0007] Preferably, the base body includes a first base and a second base, and the first K-wire is arranged on the first base.

[0008] Preferably, the guide assembly includes four moving blocks, four threaded members and several nuts, one end of the four threaded members are fixedly mounted on the first base through nuts, the other end of the four threaded members are fixedly mounted on the second base through nuts, and the four moving blocks are movably sleeved on the outside of the four threaded members, and two of the moving blocks are respectively connected to support shafts, the other ends of the two support shafts are respectively inserted into the shaft grooves of the other two moving blocks, and the two Kirschner wire fixing blocks are respectively located between each two moving blocks and movably sleeved on the corresponding support shafts.

[0009] Preferably, the adjustment assembly includes four cleat nuts or four nuts, and the four cleat nuts or the four nuts are respectively threadedly connected to the outer walls of the four threaded parts.

[0010] Preferably, each of the Kirschner wire fixing blocks and the corresponding moving blocks at the upper and lower ends form a group of moving mechanisms, and the adjustment assembly includes two groups of adjustment mechanisms, each group of adjustment mechanisms corresponds to each group of moving mechanisms; Each group of the adjustment mechanisms includes an L-shaped plate fixedly connected to the two moving blocks in each group of moving mechanisms, two worm gears rotatably mounted on the L-shaped plate through bearings, a worm meshingly connected to the two worm gears, and an adjustment handle fixedly connected to one end of the worm gear, and the four worm gears are respectively threadedly connected to the corresponding threaded parts, and the two ends of the worm gear are respectively movably mounted on the L-shaped plate.

[0011] Preferably, the guide assembly includes four moving blocks, four threaded members, an upper limit plate and a lower limit plate, and one end of the four threaded members are rotatably mounted on the first base through bearings, and the other end of the four threaded members are rotatably mounted on the second base through bearings, and the upper limit plate is jointly mounted on the top of the first base and the second base, and the lower limit plate is jointly mounted on the bottom of the first base and the second base, and the four moving blocks are movably sleeved on the outside of the four threaded members and correspondingly slidably arranged in the limit grooves of the upper limit plate and the lower limit plate, and two of the moving blocks are respectively connected to support shafts, and the other ends of the two support shafts are respectively inserted into the shaft grooves of the other two moving blocks, and the two Kirschner wire fixing blocks are respectively located between each two moving blocks and movably sleeved on the corresponding support shafts.

[0012] Preferably, each of the Kirschner wire fixing blocks and the corresponding moving blocks at the upper and lower ends form a group of moving mechanisms, and the adjustment assembly includes two groups of adjustment mechanisms, each group of adjustment mechanisms corresponds to each group of moving mechanisms; Each group of the adjusting mechanisms includes two worm wheels, a worm and a C-shaped plate, and the two worm wheels in each group of the adjusting mechanisms are fixedly connected to two threaded parts respectively. The worm is rotatably mounted on the upper limit plate and the lower limit plate, and is engaged with the two worm wheels through spiral teeth at the same time. The C-shaped plate is arranged between the upper limit plate and the lower limit plate, and is threadedly connected to the two threaded parts at the same time, and one end of the worm is connected to an adjusting handle.

[0013] Preferably, the guide assembly includes two moving blocks, two threaded members and a lower limit plate, one end of the two threaded members are rotatably mounted on the first base through bearings, the other end of the two threaded members are rotatably mounted on the second base through bearings, and the lower limit plate is jointly mounted on the bottom of the first base and the second base, the two moving blocks are movably sleeved on the outside of the two threaded members, and are correspondingly slidably arranged in the limit groove of the lower limit plate, and the two moving blocks are respectively connected with support shafts, one end of the two support shafts are respectively threadedly connected to the limit members, and the two Kirschner wire fixing blocks are respectively movably sleeved on the corresponding support shafts and are located between the limit members and the moving block.

[0014] Preferably, the adjustment assembly includes an adjustment handle connected to one end of the threaded member and a push block threadedly connected to the outer wall of the threaded member. The push block is arranged on one side of the moving block and is located in the limiting groove of the lower limiting plate.

[0015] Preferably, a transmission joint is connected to the adjustment handle, and the size of the transmission joint matches the size of the groove on the rotating head of the electric wrench.

[0016] By adopting the above technical solution, the beneficial effects achieved by the present invention are as follows: In the present invention, the Kirschner wire fixing block is movably installed on the moving block of the guide assembly, so that when the adjustment assembly drives the moving block, the displacement change of the Kirschner wire fixing block can not only cause the second Kirschner wire to produce a compression or stretching function, but also cause the second Kirschner wire to produce a tilting action to achieve a bending function, ensuring that the present invention can achieve bending, compression or stretching of a specific angle of the rat's coccyx to truly simulate the bending and compression of the intervertebral disc; at the same time, the adjustment assembly, in conjunction with the implementation of a thin-film pressure sensor and a digital display, makes the compression, bending and stretching forces of the present invention freely adjustable, and can more accurately measure the pressure applied by the second Kirschner wire to the rat's coccyx, so that the adjustment method of the present invention can significantly reduce the deviation between the experimental results and the actual physiological conditions, and accurately reflect the true mechanism of the occurrence and development of the disease.

[0017] In the present invention, after the base body, the guide component, the Kirschner wire fixing block and the adjustment component are assembled and matched, the structural fixing method of the present invention can provide a stable and balanced fixing effect for the device, ensuring that the device is not easy to loosen or shift during use, providing a strong guarantee for the smooth progress of the experiment and the accuracy of the data; at the same time, it can also effectively avoid the problem of fixation failure caused by rats gnawing, reduce the risk of damage or falling off of the device during the experiment, reduce the possibility of accidental interruption of the experiment, and improve the continuity and reliability of the experiment.

[0018] In the present invention, the Kirschner wire only needs to be inserted into the pinhole on the Kirschner wire fixing block to complete the connection between the Kirschner wire and the fixing block. The operation is simple and convenient, and the use efficiency is effectively improved to a certain extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a schematic diagram of the overall structure of embodiment 1 of the present invention.

[0020] Figure 2 This is a schematic diagram of the explosion structure of Example 1 of the present invention.

[0021] Figure 3 This is a schematic diagram of the overall structure of embodiment 2 of the present invention.

[0022] Figure 4 This is a schematic diagram of a viewing angle structure of the second explosion embodiment of the present invention.

[0023] Figure 5 This is a structural schematic diagram of another perspective of the explosion of Example 2 of the present invention.

[0024] Figure 6 This is a schematic diagram of the overall structure of embodiment 3 of the present invention.

[0025] Figure 7 This is a schematic diagram of the explosion structure of Example 3 of the present invention.

[0026] Figure 8 This is a schematic diagram of the overall structure of embodiment 4 of the present invention.

[0027] Figure 9 This is a schematic diagram of the explosion structure of Example 4 of the present invention.

[0028] Figure 10 Schematic diagram of the thin-film pressure sensor of the present invention.

[0029] In the figure: 1, base body; 11, first base; 12, second base; 2. First Kirschner wire; 3. Guide assembly; 31. Moving block; 32. Threaded member; 33. Nut; 34. Support shaft; 35. Upper limit plate; 36. Lower limit plate; 4. Kirschner wire fixation block; 5. Second Kirschner wire; 6. Adjustment assembly; 61. L-shaped plate; 62. Worm gear; 63. Worm; 64. Adjustment handle; 65. C-shaped plate; 66. Push block; 7. Sheet pressure sensor; 8. Digital display; 9. Bearing; 10. Transmission joint. DETAILED DESCRIPTION

[0030] In order to more clearly understand the above-mentioned objects, features and advantages of the present invention, the present invention is further described below in conjunction with the accompanying drawings and embodiments. It should be noted that, in the absence of conflict, the embodiments of the present application and the features therein can be combined with each other.

[0031] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways than those described herein. Therefore, the present invention is not limited to the specific embodiments disclosed below. Example

[0032] like Figure 1 、 Figure 2 and Figure 10As shown, the present invention provides an adjustable rat intervertebral disc degeneration modeling device, comprising a base body 1, a first Kirschner wire 2 for fixing to the coccyx of the rat's tail being inserted through the base body 1, a guide assembly 3 mounted on the base body 1, two Kirschner wire fixing blocks 4 being movably mounted on the guide assembly 3, a second Kirschner wire 5 being inserted through both Kirschner wire fixing blocks 4, an adjustment assembly 6 being provided on the guide assembly 3 for driving the Kirschner wire fixing blocks 4 to angularly offset, thereby causing the second Kirschner wire 5 to tilt, and a thin-film pressure sensor 7 for pressure detection being provided between the adjustment assembly 6 and the movable block 31 in the guide assembly 3. One end of the signal transmission line of the thin-film pressure sensor 7 is electrically connected to a digital display 8. The thin-film pressure sensor 7 is used to convert the pressure received into an electrical signal, and the digital display 8 is used to receive the electrical signal and display the pressure data in real time, thereby completing real-time monitoring of the compression amount and ensuring accurate measurement. It is worth noting that the present invention is intended to protect the physical structure and does not seek to protect the electronic control and software components. Therefore, the present invention does not elaborate on the thin-film pressure sensor 7 and digital display 8. Although the present invention does not provide detailed descriptions of these components, those skilled in the art will be able to purchase thin-film pressure sensors 7 and digital displays 8 on the market. It is also worth noting that the detection portion of the thin-film pressure sensor 7 in the present invention can be designed as a "C" shape to ensure that the "C"-shaped thin-film pressure sensor 7 can be firmly attached to the threaded member 32, facilitating the application of pressure to the thin-film pressure sensor 7 when the adjustment assembly 6 moves, ensuring that the thin-film pressure sensor 7 converts pressure into an electrical signal in real time.

[0033] In this embodiment, combined with Figure 2 As shown, the base body 1 includes a first base 11 and a second base 12. Each of the first base 11 and the second base 12 has a pinhole for inserting a first K-wire 2, and the first K-wire 2 is disposed on the first base 11. It is worth noting that in this embodiment, the second K-wire 5 on the two K-wire fixing blocks 4 and the first K-wire 2 on the first base 11 are used to fix the rat's coccyx; if necessary, a K-wire can also be inserted into the pinhole of the second base 12 for use.

[0034] In this embodiment, the guide assembly 3 includes four moving blocks 31, four threaded members 32 and several nuts 33. One end of the four threaded members 32 is fixedly mounted on the first base 11 through the nut 33, and the other end of the four threaded members 32 is fixedly mounted on the second base 12 through the nut 33. The four moving blocks 31 are movably sleeved on the outside of the four threaded members 32, and two of the moving blocks 31 are respectively connected to the support shaft 34, and the other two moving blocks 31 are respectively provided with an axis groove, and the other ends of the two support shafts 34 are respectively inserted into the axis grooves of the other two moving blocks 31, and the two Kirschner wire fixing blocks 4 are respectively located between each two moving blocks 31 and are movably sleeved on the corresponding support shaft 34.

[0035] Furthermore, the adjustment assembly 6 includes four cleat nuts or four nuts 33 , and the four cleat nuts or four nuts 33 are respectively threadedly connected to the outer walls of the four threaded members 32 .

[0036] In this embodiment, combined with Figure 1 、 Figure 2 and Figure 10 As shown, when working, the base body 1, the guide component 3, the Kirschner wire fixing block 4 and the adjustment component 6 are first assembled, and then the first Kirschner wire 2 and the second Kirschner wire 5 are fixed correspondingly on the coccygeal vertebrae of two adjacent rat tails. During this period, the first Kirschner wire 2 is passed through the first base 11, and the second Kirschner wire 5 is passed through the two Kirschner wire fixing blocks 4. In this way, when the horn nut or the nut 33 is rotated, the horn nut or the nut 33 applies pressure to the thin-film pressure sensor 7, and simultaneously pushes the corresponding moving block 31 to move linearly, so that the thin-film pressure sensor 7 can convert the pressure into an electrical signal after receiving the pressure, and display the pressure data through the digital display 8 to ensure that the applied pressure can be measured in real time, so as to achieve no bias during the continuous pressure application on the rat coccygeal vertebrae, so as to simulate the actual pressure-bearing conditions of a normal intervertebral disc.

[0037] When the rat's coccyx needs to be bent and compressed at a specific angle to simulate the actual bending and compression of the intervertebral disc, the two clevis nuts or nuts 33 are rotated one by one, so that the two clevis nuts or nuts 33 on the same side are rotated, which can push the two movable blocks 31 on the same side, causing the movable blocks 31 to move linearly. The movable blocks 31 can then push the Kirschner wire fixing block 4, which is movably mounted on the support shaft 34, to produce a displacement change, causing the second Kirschner wire 5 to tilt under the force of the Kirschner wire fixing block 4, thereby achieving the specific bending and compression of the rat's coccyx. This can truly simulate the bending and compression of the intervertebral disc and ensure that the present invention can achieve switching between fixed pressure and fixed compression on a single device. Furthermore, when the clevis nuts or nuts 33 are rotated, they apply pressure to the thin-film pressure sensor 7, so that the thin-film pressure sensor 7 can convert the pressure received into an electrical signal and display the pressure data on the digital display 8, ensuring that the compression amount can be precisely controlled, facilitating the operator to accurately apply pressure to the rat's coccyx.

[0038] In this embodiment, as a further feature, the Kirschner wire only needs to be inserted into the pinhole on the Kirschner wire fixing block 4 to complete the connection between the Kirschner wire and the fixing block. The operation is simple and convenient, and the efficiency is effectively improved to a certain extent.

[0039] In this embodiment, as a further improvement, the fixing method through a plurality of nuts 33 can provide a stable and balanced fixing effect for the device, ensuring that the device is not easy to loosen or shift during use, providing a strong guarantee for the smooth progress of the experiment and the accuracy of the data; and the structural design of this fixing method can effectively avoid the problem of fixation failure caused by rats gnawing, reduce the risk of damage or falling off of the device during the experiment, and at the same time reduce the possibility of accidental interruption of the experiment, thereby improving the continuity and reliability of the experiment. Example

[0040] like Figure 3 、 Figure 4 、 Figure 5 and Figure 10 As shown, the structure of this embodiment is substantially the same as that of the first embodiment, except that: each K-wire fixing block 4 and the corresponding moving blocks 31 at the upper and lower ends respectively form a set of moving mechanisms, and the adjustment assembly 6 includes two sets of adjustment mechanisms, each set of adjustment mechanisms corresponding to each set of moving mechanisms; wherein, the two sets of moving mechanisms composed of the two K-wire fixing blocks 4 and the four moving blocks 31 are symmetrical, and the two sets of adjustment mechanisms correspond one to one to the two sets of moving mechanisms and are symmetrically arranged; Furthermore, the structures of the two groups of adjustment mechanisms are the same, and each group of adjustment mechanisms includes an L-shaped plate 61 fixedly connected to the two moving blocks 31 in each group of moving mechanisms, two worm gears 62 rotatably mounted on the L-shaped plate 61 through bearings 9, a worm 63 meshingly connected to the two worm gears 62, and an adjustment handle 64 fixedly connected to one end of the worm 63, and the four worm gears 62 are respectively threadedly connected to the corresponding threaded parts 32, and the two ends of the worm 63 are respectively movably mounted on the L-shaped plate 61.

[0041] Specifically, the surface of the L-shaped plate 61 is provided with an anti-collision groove corresponding to the Kirschner wire fixing block 4. The design of the anti-collision groove can effectively prevent the L-shaped plate 61 from restricting the Kirschner wire fixing block 4. Then, when the Kirschner wire fixing block 4 produces a displacement change and due to the force relationship of the second Kirschner wire 5, the Kirschner wire fixing block 4 can support the shaft 34 as the center of the circle to rotate smoothly, ensuring that the second Kirschner wire 5 can produce a tilting action, so as to realize the rat coccyx to complete a specific angle of bending and compression, thereby being able to truly simulate the bending and compression of the intervertebral disc.

[0042] Furthermore, the worm 63 is rotatably mounted on the L-shaped plate 61 through a bearing 9, and two helical teeth are provided on the surface of the worm 63, and the worm 63 is meshed with the corresponding worm wheel 62 through the two helical teeth; and the inner ring side of the worm wheel 62 is threadedly connected to the threaded member 32, and the inner ring side diameter of the bearing 9 connected to the worm wheel 62 is larger than the inner ring side diameter of the worm wheel 62, so as to ensure that the bearing 9 connected to the worm wheel 62 is fixedly mounted on the L-shaped plate 61 while being in a movable socket relationship with the threaded member 32, so as to ensure that when the worm 63 drives the worm wheel 62 to rotate, the worm wheel 62 can move linearly on the threaded member 32.

[0043] In this embodiment, combined with Figure 3 、 Figure 4 、 Figure 5 and Figure 10 As shown, when working, the base body 1, the guide component 3, the Kirschner wire fixing block 4 and the adjustment component 6 are first assembled, and then the first Kirschner wire 2 and the second Kirschner wire 5 are correspondingly fixed on the coccyx of two adjacent rat tails. During this period, the first Kirschner wire 2 is inserted into the first base 11, and the second Kirschner wire 5 is inserted into the two Kirschner wire fixing blocks 4. In this way, by rotating the adjustment component 6, the worm gear 62 in the adjustment component 6 can apply pressure to the thin-film pressure sensor 7, and synchronously push the corresponding moving block 31 to move linearly, so that the thin-film pressure sensor 7 can convert the pressure into an electrical signal after receiving the pressure, and display the pressure data through the digital display 8 to ensure that the applied pressure can be measured in real time, so that no bias pressure will be generated during the continuous pressure application on the rat coccyx, so as to simulate the actual pressure-bearing condition of the normal intervertebral disc.

[0044] When the rat's coccyx needs to be bent and compressed at a specific angle to simulate the actual bending and compression of the intervertebral disc, an adjusting handle 64 is rotated so that the adjusting handle 64 can drive the worm 63 to rotate, and then the worm 63 can synchronously drive the two worm wheels 62 to rotate on the threaded member 32, so that the two worm wheels 62 on the same side can rotate to make the two moving blocks 31 on the same side move linearly, and the moving block 31 can drive the Kirschner wire fixing block 4 to produce a displacement change, so that the second Kirschner wire 5 is tilted by the force of the Kirschner wire fixing block 4, so that the rat's coccyx can complete the bending and compression of the specific angle, and thus can truly simulate the bending and compression of the intervertebral disc, ensuring that the present invention can achieve switching between fixed pressure and fixed compression on one device. When the two worm gears 62 on the same side drive the moving block 31 on the same side to move, the worm gear 62 can apply pressure to the thin-film pressure sensor 7, so that the thin-film pressure sensor 7 can convert the pressure into an electrical signal after receiving the pressure, and display the pressure data through the digital display 8 to ensure that the compression amount can be precisely controlled, so that the staff can accurately apply compression and bending force to the rat's tail vertebrae.

[0045] It is worth noting that in this embodiment, through the cooperation of the L-shaped plate 61, the worm gear 62, the worm 63 and the adjustment handle 64, the two moving blocks 31 on the same side can be adjusted synchronously and quickly, ensuring that the pressure exerted by each worm gear 62 on the moving block 31 is the same. Compared with the adjustment method of the single ram nut or nut 33 in the first embodiment, the adjustment of this embodiment is more time-saving and labor-saving, and the compression amount adjustment is quick and consistent, effectively improving the accuracy of the experimental data. Example

[0046] like Figure 6 、 Figure 7 and Figure 10 As shown, the structure of this embodiment is roughly the same as that of the first embodiment, except that the guide assembly 3 includes four moving blocks 31, four threaded members 32, an upper limit plate 35 and a lower limit plate 36, and one end of the four threaded members 32 is rotatably mounted on the first base 11 through bearings 9, and the other end of the four threaded members 32 is rotatably mounted on the second base 12 through bearings 9, and the upper limit plate 35 is jointly mounted on the top of the first base 11 and the second base 12, and the lower limit plate 36 is jointly mounted on the first base 11 And the bottom of the second base 12, and the four moving blocks 31 are respectively movably mounted on the outside of the four screw members 32, and are correspondingly slidably arranged in the limit grooves of the upper limit plate 35 and the lower limit plate 36, and two of the moving blocks 31 are respectively connected to the support shafts 34, and the other two moving blocks 31 are respectively provided with shaft grooves, and the other ends of the two support shafts 34 are respectively inserted into the shaft grooves of the other two moving blocks 31, and the two Kirschner wire fixing blocks 4 are respectively located between every two moving blocks 31, and are movably mounted on the corresponding support shafts 34.

[0047] In this embodiment, each K-wire fixing block 4 and the corresponding moving blocks 31 at the upper and lower ends form a set of moving mechanisms, and the adjustment assembly 6 includes two sets of adjustment mechanisms, each set of adjustment mechanisms corresponding to each set of moving mechanisms; wherein, the two sets of moving mechanisms composed of the two K-wire fixing blocks 4 and the four moving blocks 31 are symmetrical, and the two sets of adjustment mechanisms correspond one to one to the two sets of moving mechanisms and are symmetrically arranged; Each set of adjustment mechanisms includes two worm wheels 62, a worm 63 and a C-shaped plate 65, and the two worm wheels 62 in each set of adjustment mechanisms are respectively fixedly connected to the two threaded parts 32. The worm 63 is rotatably installed on the upper limit plate 35 and the lower limit plate 36, and at the same time engages with the two worm wheels 62 through two spiral teeth set on the outer wall. The C-shaped plate 65 is arranged between the upper limit plate 35 and the lower limit plate 36, and is simultaneously threadedly connected to the two threaded parts 32, and one end of the worm 63 is connected to the adjustment handle 64.

[0048] In this embodiment, combined with Figure 6 、 Figure 7 and Figure 10 As shown, when working, the base body 1, the guide component 3, the Kirschner wire fixing block 4 and the adjustment component 6 are first assembled, and then the first Kirschner wire 2 and the second Kirschner wire 5 are correspondingly fixed on the coccyx of two adjacent rat tails. During this period, the first Kirschner wire 2 is inserted into the first base 11, and the second Kirschner wire 5 is inserted into the two Kirschner wire fixing blocks 4. In this way, by rotating the adjustment component 6, the C-shaped plate 65 in the adjustment component 6 can apply pressure to the thin-film pressure sensor 7, and synchronously push the corresponding moving block 31 to move linearly, so that the thin-film pressure sensor 7 can convert the pressure into an electrical signal after receiving the pressure, and display the pressure data through the digital display 8 to ensure that the applied pressure can be measured in real time, so as to achieve no bias during the continuous pressure application on the rat coccyx, so as to simulate the actual pressure-bearing condition of the normal intervertebral disc.

[0049] When the rat's coccyx needs to be bent and compressed at a specific angle to simulate the actual bending and compression of the intervertebral disc, an adjusting handle 64 is rotated so that the adjusting handle 64 can drive the worm 63 to rotate, and then the worm 63 can synchronously drive the two worm wheels 62 to rotate. When the two worm wheels 62 rotate, they can respectively drive the corresponding fixedly connected threaded parts 32 to rotate, so that when the threaded parts 32 rotate, they can drive the C-shaped plate 65 to move. After the C-shaped plate 65 moves, the two moving blocks 31 on the same side can move linearly, and the moving block 31 can drive the Kirschner wire fixing block 4 to produce a displacement change, so that the second Kirschner wire 5 is tilted by the force of the Kirschner wire fixing block 4, so that the rat's coccyx can complete the bending and compression at a specific angle, thereby being able to truly simulate the bending and compression of the intervertebral disc. When the C-shaped plate 65 drives the movable block 31 on the same side to move, the C-shaped plate 65 can apply pressure to the thin-sheet pressure sensor 7, so that the thin-sheet pressure sensor 7 can convert the pressure into an electrical signal after receiving the pressure, and display the pressure data through the digital display 8 to ensure that the compression amount can be precisely controlled, so that the staff can accurately apply compression and bending force to the rat's tail vertebrae, so that the adjustment method of the present invention can significantly reduce the deviation between the experimental results and the actual physiological conditions, and accurately reflect the true mechanism of the occurrence and development of the disease. Example

[0050] like Figure 8 、 Figure 9 and Figure 10 As shown, the structure of this embodiment is roughly the same as that of embodiment 1, except that: the guide assembly 3 includes two moving blocks 31, two threaded members 32 and a lower limit plate 36, one end of the two threaded members 32 is rotatably mounted on the first base 11 through bearings 9, the other end of the two threaded members 32 is rotatably mounted on the second base 12 through bearings 9, and the lower limit plate 36 is jointly installed at the bottom of the first base 11 and the second base 12, the two moving blocks 31 are movably mounted on the outside of the two threaded members 32, and are correspondingly slidably arranged in the limit groove of the lower limit plate 36, and the two moving blocks 31 are respectively connected to support shafts 34, one end of the two support shafts 34 is respectively threadedly connected to the limit members, and the two Kirschner wire fixing blocks 4 are respectively movably mounted on the corresponding support shafts 34, and are located between the limit members and the moving blocks 31.

[0051] In this embodiment, the adjustment assembly 6 includes an adjustment handle 64 connected to one end of the threaded member 32 and a push block 66 threadedly connected to the outer wall of the threaded member 32. The push block 66 is arranged on one side of the moving block 31 and is located in the limiting groove of the lower limiting plate 36.

[0052] In this embodiment, combined with Figure 8 、 Figure 9 and Figure 10As shown, when working, the base body 1, the guide component 3, the Kirschner wire fixing block 4 and the adjustment component 6 are first assembled, and then the first Kirschner wire 2 and the second Kirschner wire 5 are correspondingly fixed on the coccyx of two adjacent rat tails. During this period, the first Kirschner wire 2 is inserted into the first base 11, and the second Kirschner wire 5 is inserted into the two Kirschner wire fixing blocks 4. In this way, by rotating the adjustment component 6, the pushing block 66 in the adjustment component 6 can apply pressure to the thin-film pressure sensor 7, and synchronously push the corresponding moving block 31 to move linearly, so that the thin-film pressure sensor 7 can convert the pressure into an electrical signal after receiving the pressure, and display the pressure data through the digital display 8 to ensure that the applied pressure can be measured in real time, so as to achieve no bias during the continuous pressure application on the rat coccyx, so as to simulate the actual pressure-bearing condition of the normal intervertebral disc.

[0053] When the rat's coccyx needs to be bent and compressed at a specific angle to simulate the actual bending and compression of the intervertebral disc, an adjusting handle 64 is rotated so that the adjusting handle 64 can drive the threaded member 32 to rotate, and then the threaded member 32 can drive the pushing block 66 to move after the pushing block 66 moves, so that the moving block 31 can move linearly, and the moving block 31 can drive the Kirschner wire fixing block 4 to produce a displacement change, so that the second Kirschner wire 5 is tilted by the force of the Kirschner wire fixing block 4, so that the rat's coccyx can complete the bending and compression at a specific angle, thereby being able to truly simulate the bending and compression of the intervertebral disc. When the pushing block 66 drives the moving block 31 on the same side to move, the pushing block 66 can apply pressure to the thin-film pressure sensor 7, so that the thin-film pressure sensor 7 can convert the pressure into an electrical signal after receiving the pressure, and display the pressure data through the digital display 8 to ensure that the compression amount can be precisely controlled, so that the staff can accurately apply compression and bending force to the rat's tail vertebrae, so that the adjustment method of the present invention can significantly reduce the deviation between the experimental results and the actual physiological conditions, and accurately reflect the true mechanism of the occurrence and development of the disease.

[0054] Furthermore, in the second, third, and fourth embodiments, a transmission connector 10 is connected to the adjustment handle 64. The dimensions of the transmission connector 10 match the dimensions of the groove on the electric wrench's rotating head. The design of the transmission connector 10 allows the worm 63 to be rotated not only manually by directly rotating the adjustment handle 64, but also by using an external electric wrench with a socket, which drives the worm 63 through the transmission connector 10, saving time and effort.

[0055] As another embodiment, when it is necessary to bend and stretch the rat's coccyx at a specific angle, unlike in Examples 1, 2, 3, and 4, it is only necessary to swap the positions of the guide assembly 3 and the adjustment assembly 6 during assembly of the device so that the moving block 31 in the guide assembly 3 can be moved away from the first base 11 when the adjustment assembly 6 is driven, thereby achieving bending and stretching the rat's coccyx at a specific angle. The specific embodiment is as follows: Combine Figure 1 and Figure 2 As shown, the horn nut or nut 33 originally placed between the moving block 31 and the second base 12 in Example 1 is moved between the first base 11 and the moving block 31 during assembly, so that the moving block 31 is pushed closer to the second base 12 through its rotation, thereby realizing the stretching and bending stretching function of the second Kirschner wire 5 on the rat coccyx.

[0056] Combine Figure 3 、 Figure 4 and Figure 5 As shown, the adjustment component 6 originally placed between the moving block 31 and the second base 12 in the second embodiment is moved between the first base 11 and the moving block 31 during assembly, so that when the worm gear 62 is driven to rotate by the worm 63, the worm gear 62 can push the moving block 31 closer to the second base 12, thereby realizing the stretching and bending stretching function of the second Kirschner wire 5 on the rat coccyx.

[0057] Combine Figure 6 and Figure 7 As shown, the C-shaped plate 65 originally placed between the moving block 31 and the second base 12 in Example 3 is moved between the first base 11 and the moving block 31 during assembly. When the worm gear 62 drives the threaded member 32 to rotate, the C-shaped plate 65 can push the moving block 31 closer to the second base 12, thereby realizing the stretching and bending stretching function of the second Kirschner wire 5 on the rat coccyx.

[0058] Combine Figure 8 and Figure 9 As shown, the pushing block 66 originally placed between the moving block 31 and the second base 12 in the fourth embodiment is moved between the first base 11 and the moving block 31 during assembly, so that when the screw member 32 is rotated, the pushing block 66 can push the moving block 31 closer to the second base 12, thereby realizing the stretching and bending stretching function of the second Kirschner wire 5 on the rat coccyx.

[0059] When the second Kirschner wire 5 is used to stretch and bend the rat's coccyx, the thin-film pressure sensors 7 are placed by the staff between the moving block 31 and the horn nut or nut 33, between the moving block 31 and the worm gear 62, between the moving block 31 and the C-shaped plate 65, and between the moving block 31 and the pushing block 66, so as to ensure that the stretching amount can be precisely controlled, making it convenient for the staff to accurately apply stretching and bending forces to the rat's coccyx, so that the adjustment method of the present invention can significantly reduce the deviation between the experimental results and the actual physiological conditions, and accurately reflect the true mechanism of the occurrence and development of the disease.

[0060] In summary, the present invention utilizes a Kirschner wire fixing block 4 movably mounted on the movable block 31 of the guide assembly 3. This allows the adjustment assembly 6 to drive the movable block 31, resulting in the displacement of the Kirschner wire fixing block 4, which not only compresses or stretches the second Kirschner wire 5 but also tilts the second Kirschner wire 5, achieving bending or stretching. This ensures that the present invention can achieve specific angles of bending, compression, or stretching of the rat's coccyx, effectively simulating the bending, compression, or stretching of the intervertebral disc. Furthermore, the adjustment assembly 6, in conjunction with the thin-film pressure sensor 7 and digital display 8, allows the present invention to freely adjust the compression, bending, and stretching forces, and accurately measures the pressure applied by the second Kirschner wire 5 to the rat's coccyx. This significantly reduces the deviation between experimental results and actual physiological conditions, accurately reflecting the true mechanism of disease development. Furthermore, the present invention requires only that the Kirschner wire be inserted into the pinhole of the Kirschner wire fixing block 4 to complete the connection between the Kirschner wire and the fixing block, resulting in simple and convenient operation and significantly improved efficiency. Furthermore, the structural fixing method of the present invention can provide a stable and balanced fixation effect for the device, ensuring that the device is not easily loosened or shifted during use, providing a strong guarantee for the smooth progress of experiments and the accuracy of data. In addition, compared with Example 4, the fixing method designs of Examples 1, 2, and 3 can effectively avoid the problem of fixation failure caused by rats gnawing, reduce the risk of damage or detachment of the device during experiments, and reduce the possibility of accidental interruption of experiments, thereby improving the continuity and reliability of experiments.

[0061] In the present invention, the term "plurality" refers to two or more, unless otherwise expressly defined. The term "and / or" used herein includes any and all combinations of one or more of the relevant listed items. Terms such as "installed", "connected", "connected", and "fixed" should be understood in a broad sense. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; "connected" can be a direct connection or an indirect connection through an intermediate medium. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances.

[0062] It should be noted that when an element is referred to as being "assembled to," "mounted to," "fixed to," or "disposed on" another element, it may be directly on the other element or there may be an intermediate element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only implementation methods.

[0063] Throughout this specification, terms such as "one embodiment," "some embodiments," and "specific embodiments" mean that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in at least one embodiment or example of the present invention. In this specification, schematic representations of these terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0064] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and alterations may be made to the embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the claims and their equivalents.

Claims

1. An adjustable rat intervertebral disc degeneration modeling device, characterized in that: The invention comprises a base body (1), wherein a first Kirschner wire (2) for fixing to the coccyx of a rat is passed through the base body (1), and a guide assembly (3) is installed on the base body (1), and two Kirschner wire fixing blocks (4) are movably installed on the guide assembly (3), and a second Kirschner wire (5) is passed through the two Kirschner wire fixing blocks (4), and an adjustment assembly (6) is provided on the guide assembly (3), and the adjustment assembly (6) is used to drive the Kirschner wire fixing blocks (4) to deflect in an angle so as to cause the second Kirschner wire (5) to produce a tilting action, and a thin-film pressure sensor (7) for pressure detection is provided between the adjustment assembly (6) and the moving block (31) in the guide assembly (3), and one end of the signal transmission line of the thin-film pressure sensor (7) is electrically connected to a digital display (8).

2. The adjustable rat intervertebral disc degeneration modeling device according to claim 1, characterized in that: The base body (1) comprises a first base (11) and a second base (12), and the first Kirschner wire (2) is arranged on the first base (11).

3. The adjustable rat intervertebral disc degeneration modeling device according to claim 2, characterized in that: The guide assembly (3) includes four moving blocks (31), four threaded members (32) and a plurality of nuts (33), one end of each of the four threaded members (32) is fixedly mounted on the first base (11) through a nut (33), and the other end of each of the four threaded members (32) is fixedly mounted on the second base (12) through a nut (33), and the four moving blocks (31) are movably sleeved on the outside of the four threaded members (32), and two of the moving blocks (31) are respectively connected to a support shaft (34), and the other ends of the two support shafts (34) are respectively inserted into the shaft grooves of the other two moving blocks (31), and the two Kirschner wire fixing blocks (4) are respectively located between each two moving blocks (31) and movably sleeved on the corresponding support shaft (34).

4. The adjustable rat intervertebral disc degeneration modeling device according to claim 3, characterized in that: The adjustment assembly (6) comprises four ram's horn nuts or four nuts (33), and the four ram's horn nuts or four nuts (33) are respectively threadedly connected to the outer walls of the four threaded members (32).

5. The adjustable rat intervertebral disc degeneration modeling device according to claim 3, characterized in that: Each of the Kirschner wire fixing blocks (4) and the corresponding moving blocks (31) at the upper and lower ends form a set of moving mechanisms, and the adjustment component (6) includes two sets of adjustment mechanisms, each set of adjustment mechanisms corresponds to each set of moving mechanisms; Each group of the adjustment mechanisms comprises an L-shaped plate (61) fixedly connected to the two moving blocks (31) in each group of the moving mechanisms, two worm wheels (62) rotatably mounted on the L-shaped plate (61) through bearings (9), a worm (63) meshingly connected to the two worm wheels (62), and an adjustment handle (64) fixedly connected to one end of the worm (63), and the four worm wheels (62) are respectively threadedly connected to the corresponding threaded members (32), and the two ends of the worm (63) are respectively movably mounted on the L-shaped plate (61).

6. The adjustable rat intervertebral disc degeneration modeling device according to claim 2, characterized in that: The guide assembly (3) includes four moving blocks (31), four threaded members (32), an upper limit plate (35) and a lower limit plate (36), and one end of the four threaded members (32) is rotatably mounted on the first base (11) through bearings (9), and the other end of the four threaded members (32) is rotatably mounted on the second base (12) through bearings (9), and the upper limit plate (35) is mounted on the top of the first base (11) and the second base (12), and the lower limit plate (36) is mounted on the top of the first base (11) and the second base (12). The bottom of the second base (12), and the four moving blocks (31) are movably mounted on the outside of the four threaded members (32), and are correspondingly slidably arranged in the limit grooves of the upper limit plate (35) and the lower limit plate (36), and two of the moving blocks (31) are respectively connected to support shafts (34), and the other ends of the two support shafts (34) are respectively inserted into the shaft grooves of the other two moving blocks (31), and the two Kirschner wire fixing blocks (4) are respectively located between each two moving blocks (31) and are movably mounted on the corresponding support shafts (34).

7. The adjustable rat intervertebral disc degeneration modeling device according to claim 6, characterized in that: Each of the Kirschner wire fixing blocks (4) and the corresponding moving blocks (31) at the upper and lower ends form a set of moving mechanisms, and the adjustment component (6) includes two sets of adjustment mechanisms, each set of adjustment mechanisms corresponds to each set of moving mechanisms; Each group of the adjustment mechanisms comprises two worm wheels (62), a worm (63) and a C-shaped plate (65), and the two worm wheels (62) in each group of the adjustment mechanisms are fixedly connected to the two threaded members (32) respectively. The worm (63) is rotatably mounted on the upper limit plate (35) and the lower limit plate (36), and is simultaneously engaged with the two worm wheels (62) through helical teeth. The C-shaped plate (65) is arranged between the upper limit plate (35) and the lower limit plate (36), and is simultaneously threadedly connected to the two threaded members (32), and one end of the worm (63) is connected to an adjustment handle (64).

8. The adjustable rat intervertebral disc degeneration modeling device according to claim 2, characterized in that: The guide assembly (3) includes two moving blocks (31), two threaded members (32) and a lower limit plate (36), one end of the two threaded members (32) is rotatably mounted on the first base (11) through a bearing (9), the other end of the two threaded members (32) is rotatably mounted on the second base (12) through a bearing (9), and the lower limit plate (36) is jointly mounted on the bottom of the first base (11) and the second base (12), the two moving blocks (31) are movably sleeved on the outside of the two threaded members (32), and are correspondingly slidably arranged in the limit groove of the lower limit plate (36), and the two moving blocks (31) are respectively connected to a support shaft (34), one end of the two support shafts (34) is respectively threadedly connected to the limit member, and the two Kirschner wire fixing blocks (4) are respectively movably sleeved on the corresponding support shaft (34) and are located between the limit member and the moving block (31).

9. The adjustable rat intervertebral disc degeneration modeling device according to claim 8, characterized in that: The adjustment assembly (6) includes an adjustment handle (64) connected to one end of the threaded member (32) and a push block (66) threadedly connected to the outer wall of the threaded member (32). The push block (66) is arranged on one side of the moving block (31) and is located in the limiting groove of the lower limiting plate (36).

10. An adjustable rat intervertebral disc degeneration modeling device according to any one of claims 5, 7 or 9, characterized in that: A transmission joint (10) is connected to the adjustment handle (64), and the size of the transmission joint (10) matches the size of the groove on the rotating head of the electric wrench.

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